Relevant bibliographies by topics / Retinal detachment

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  1. Journal articles
  2. Dissertations / Theses
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  5. Conference papers
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Academic literature on the topic 'Retinal detachment'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 June 2025

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Journal articles on the topic "Retinal detachment"

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Ashan, Haves. "Karakteristik Laser Retinopexy pada Pasiendengan Tear Retina di Divisi Vitreoretina RS Cipto Mangunkusomo Periode Januari – Desember 2018." Health & Medical Journal 1, no. 2 (2019): 28–33. http://dx.doi.org/10.33854/heme.v1i2.237.

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Retinal detachment is a serious condition that threatens vision so that it can cause complications of blindness. The only treatment for retinal detachment is surgery, where not all surgical procedures in retinal detachment cases have a good success rate. Therefore, it is very important to be able to find tears in the retina, before developing further into detachments. Retinopexy lasers performed with the aim of causing adhesion around the tear in the retina, have been recommended as an action to prevent complications of retinal detachment. Retinopexy laser has an important role in patients with retinal tear who have symptoms of floaters and flashing and persistent traction in the retina especially in the area around the retinal tear, because symptomatic retinal tear is likely to develop into a complication of retinal detachment. However, although laser retinopexy is often recommended, in fact, the effectiveness of this action is still controversial.
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Syuhada, Rahmat, Ade Utia Detty, Mizar Erianto, and Rizal Kamaludin Hidayat. "Tajam Penglihatan Pra Dan Pasca Operasi Pars Plana Vitrektomi Pada Pasien Ablasio Retina Di Rumah Sakit Pertamina Bintang Amin Bandar Lampung." Malahayati Nursing Journal 3, no. 4 (2021): 617–25. http://dx.doi.org/10.33024/mnj.v3i4.4378.

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ABSTRACT: PRE AND POST OPERATION OF VITRECTOMIC PARS PLANE FOR ABLASIO RETINA PATIENTS AT PERTAMINA HOSPITAL BINTANG AMIN BANDAR LAMPUNG Background :Retinal detachment is a condition in which the sensory parts of the retina (photoreceptors and deep tissue layers) and the retinal pigment epithelium (RPE) are separated (Budhiastra, 2016). the world, which is 1 in 10,000 population. And the average age of 40-70 years is the most susceptible to retinal detachment. This prevalence can increase if the patient with retinal detachment has several other conditions such as aphaxia / pseudophakia, high myopia and trauma. in young people they are more likely to experience retinal detachment caused by trauma, and in people aged 25-45 years, retinal detachment is more common due to high myopia. Purpose: The purpose of this study was to determine the sharp vision of pre and post pars plana vitrectomy patients with retinal detachment at Pertamina Bintang Amin Hospital in Bandar Lampung in 2020. Result : The results of 60 respondents with visual acuity from retinal detachment patients who successfully increased were 47 respondents with a percentage (78.3%) and 13 respondents with retinal detachment who did not improve were 13 respondents with a percentage (21.7%) and retinal detachment patients with retinal detachments were found. As many as 49 respondents managed to attach with a percentage (81.7%) for retinal detachment patients whose retina failed to adhere, 11 respondents (18.3%) were found. Conclusion : There is a significant difference between pre and post-operative Pars Plana Vitrectomy in patients with retinal detachment Keywords: Retinal Detachment, Pars Plana Vitrectomy, Sharp Eyesight INTISARI : TAJAM PENGLIHATAN PRA DAN PASCA OPERASI PARS PLANA VITREKTOMI PADA PASIEN ABLASIO RETINA DI RUMAH SAKIT PERTAMINA BINTANG AMIN BANDAR LAMPUNG TAHUN 2020 Pendahuluan: Ablasio retina adalah keadaan dimana bagian sensoris retina (fotoreseptor dan lapisan jaringan dalam) dan retinal pigment epithelium (RPE) menjadi terpisah (Budhiastra, 2016) Ablasi retina bisa diartikan juga terpisahnya sel kerucut dan batang retina dari sel epitel pigmen retina, Prevalensi ablasio retina di dunia yaitu sebanyak 1 berbanding 10.000 populasi. Dan rata-rata usia 40-70 tahun adalah yang paling rentan terkena ablasio retina. Prevalensi tersebut bisa meningkat jika penderita ablasio retina tersebut memiliki beberapa keadaan lain seperti afaksia/pseudofakia, myopi tinggi dan trauma. pada orang muda mereka lebih sering mengalami ablasio retina yang disebabkan oleh trauma, serta pada orang berusia usia 25-45 tahun ablasio retina lebih sering terjadi dikarenakan myopia tinggi.Tujuan : Tujuan dari penelitian ini adalah untuk mengetahui Tajam Penglihatan pasien ablasio retina pra dan pasca operasi pars plana vitrektomi di Rumah sakit Pertamina Bintang Amin Bandar Lampung tahun 2020.Hasil : Hasil dari 60 responden tajam penglihatan dari pasien ablasio retina yang berhasil meningkat didapatkan responden sebanyak 47 orang dengan persentase (78.3%) dan tajam penglihatan pasien ablasio retina yang tidak meningkat didapatkan sebanyak 13 reponden dengan persentase (21.7%) dan didapatkan pasien ablasio retina yang retina berhasil menempel sebanyak 49 responden dengan persentase (81.7%) untuk pasien ablasio retina yang retina gagal menempel didapatkan responden sebanyak 11 dengan persentase (18.3%). Kesimpulan : Terdapat perbedaan yang cukup signifikan dari tajam penglihatan pra dan pasca Operasi Pars Plana Vitrektomi pada pasien Ablasio Retina Kata kunci : Ablasio Retina, Pars Plana Vitrektomi, Tajam Penglihatan
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Sanjaya, Amicipta, Ari Andayani, and I. Made Agus Kusumadjaja. "Ablasio retina rhegmatogen bilateral: sebuah laporan kasus." Intisari Sains Medis 13, no. 2 (2022): 310–15. http://dx.doi.org/10.15562/ism.v13i2.1376.

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Background: Rhegmatogenous retinal detachment in children is rare, accounting for less than ten percent of all rhegmatogenous retinal detachments. While the majority of retinal detachments in the adult population are associated with posterior vitreous detachments, pediatric rhegmatogenous retinal detachments are often associated with trauma or an underlying congenital abnormality, although in some cases they are associated with idiopathic conditions. Case Description: A 16-year-old male patient complained about blurry vision in the right eye in the last 6 months and in the left eye in the last 5 months. Ophthalmology examination in the right eye found an inferior retinal detachment (+) at 3-9 o’clock, multiple breaks at 7-9 hours, PVR grade C, subretinal fibrosis (+), traction (+), macula off, RM (-). Meanwhile, ophthalmology examination in the left eye found an inferior retinal detachment in the left eye (+) at 3-9 o’clock, break at 5 o'clock, PVR grade C, traction (+), RM (+). The patient underwent pars plana vitrectomy in both eyes and the patient experienced an increase in visual acuity after surgery on both eyes. Conclusion: This case describes a healthy adolescent male with bilateral rhegmatogenous retinal detachment secondary to spontaneous non-traumatic retinal dialysis. The Pars Plana Vitrectomy (VPP) technique that used in this case could give high final reattachment rate and relatively good functional outcomes. VPP also has the intraocular ability to manipulate tissues and reduce immediate vitreous traction. Latar Belakang: Ablasio retina rhegmatogenous pada anak-anak jarang terjadi, terhitung kurang dari sepuluh persen dari semua ablasio retina rhegmatogen. Sementara sebagian besar ablasio retina pada populasi orang dewasa terkait dengan ablasio vitreous posterior, ablasio retina hegmatogen pediatrik sering kali berhubungan dengan trauma atau kelainan kongenital yang mendasari, walaupun pada beberapa kasus didapatkan dengan kondisi idiopatik. Laporan Kasus: Pasien laki-laki berusia 16 tahun mengeluhkan penurunan pengelihatan pada mata kanan sejak 6 bulan sebelumnya dan pada mata kiri 5 bulan sebelumnya. Pemeriksaan oftalmologi didapatkan AAR di mata kanan dengan retinal detachment (+) di inferior pada jam 3-9, multiple break pada jam 7-9, PVR grade C, fibrosis subretina (+), traksi (+), macula off, RM (-). Pemeriksaan pada mata kiri didapatkan retinal detachment di mata kiri (+) di inferior pada jam 3-9, break pada jam 5, PVR grade C, traksi (+), RM (+). Pasien menjalani vitrektomi pars plana pada kedua mata dan pasien mengalami peningkatan tajam penglihatan setelah dilakukan tindakan operasi pada kedua mata. Kesimpulan: Kasus ini menjelaskan remaja laki-laki sehat dengan bilateral ablasio retina rhegmatogen sekunder akibat retinal spontan non-trauma dialisis. Teknik Vitrektomi Pars Plana (VPP) digunakan pada kasus ini dan mampu memberikan tingkat attachment akhir yang tinggi dan hasil fungsional yang relatif baik serta kemampuan intraokular untuk memanipulasi jaringan dan mengurangi traksi vitreous secara langsung.
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Chu, Ho Cheung, Ming Yin Chan, Cheuk Wai Jeffrey Chau, Chi Pang Wong, Hok Hang Chan, and Tai Wai Wong. "The use of ocular ultrasound for the diagnosis of retinal detachment in a local accident and emergency department." Hong Kong Journal of Emergency Medicine 24, no. 6 (2017): 263–67. http://dx.doi.org/10.1177/1024907917735085.

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Objectives: This study aimed to assess the accuracy of ocular ultrasound performed by emergency physicians for diagnosis of retinal detachment. Methods: This was a prospective single-center observational study conducted between September 2013 and February 2015. All adult patients presenting to the emergency department with acute onset of visual changes were eligible to participate. Patients who met one of the following criteria were excluded: a diagnosis of retinal detachment had already been made by an ophthalmologist prior to attendance; pre-existing retinal detachment currently under treatment; hemodynamically unstable; suspected rupture eyeball; and unable to give consent. Six emergency physicians performed emergency ocular ultrasound using a linear 10-MHz ultrasound probe. An abnormal lifting of the retina or the presence of a retinal flap was considered diagnostic of retinal detachment. The final diagnosis of the ophthalmologist who was blinded to the study was used as the gold standard. Results: Among the 139 patients evaluated, 16 (12%) had retinal detachments and 14 of them were correctly identified (true positives). Of the 123 patients (88%) without retinal detachment, 107 patients were correctly identified (true negatives). The sensitivity and specificity of emergency ocular ultrasound for retinal detachment were 88% (95% confidence interval = 60 to 98) and 87% (95% confidence interval = 79 to 92), respectively. Conclusion: Emergency ocular ultrasound is a useful adjunct for the diagnosis of retinal detachment.
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Paquet, Patrick, Marie T. Fischer, Peter Distelmaier, Antje Mammen, Linda M. Meyer, and Carl-Ludwig Schönfeld. "Bilateral Simultaneous Retinal Detachment in Pseudophakia." Case Reports in Ophthalmology 6, no. 3 (2015): 298–300. http://dx.doi.org/10.1159/000439374.

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Cataract surgery is the most frequent surgical intervention, with approximately 700,000 operations per year in Germany alone. One of the most serious complications is retinal detachment, with a reported incidence rate of pseudophakic retinal detachment of 0.75-1.65%. We report the case of a patient who suffered from a simultaneous bilateral pseudophakic retinal detachment. Interestingly, the bilateral detachments in the left and the right eye started with only some hours' delay. He had no acute trigger for the retinal detachment and no risk factors besides the cataract surgery performed on both eyes some weeks earlier. Simultaneous bilateral retinal detachments will be more common, due to increasing numbers of cataract surgeries and the demographic development. We conclude that funduscopy should be regularly performed in mydriasis to avoid sight-threatening simultaneous bilateral retinal detachments.
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Tatsumi, Tomoaki, Takayuki Baba, Hirotaka Yokouchi, and Shuichi Yamamoto. "Nonperfused Peripheral Retinal Area in Eyes with Chronic Rhegmatogenous Retinal Detachment." Case Reports in Ophthalmology 11, no. 2 (2020): 385–90. http://dx.doi.org/10.1159/000509157.

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We report two cases of chronic rhegmatogenous retinal detachment with a nonperfused peripheral retinal area. Case 1 was an 84-year-old woman who presented with a bullous retinal detachment of the inferior retina and a best-corrected visual acuity of 20/500. A small horseshoe tear was detected in the peripheral superior retina. Fluorescein angiography showed a wide area of nonperfused retina in the inferior retina. The retina was successfully reattached by scleral buckling surgery. Case 2 was a 40-year-old woman who presented with a shallow retinal detachment involving the macula. There were multiple retinal breaks at the pars plana that were secondary to blunt trauma. Fluorescein angiography revealed a wide area of nonperfused retina in the inferior peripheral retina. She underwent scleral buckling surgery, and the retina was successfully reattached. Our findings indicate that clinicians should examine the peripheral retina carefully especially with fluorescein angiography to search for nonperfused areas in eyes with chronic rhegmatogenous retinal detachment.
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Rose, Rose. "Duration of rhegmatogenous retinal detachment predicts recovery of retinal sensitivity." Universa Medicina 28, no. 3 (2016): 133–38. http://dx.doi.org/10.18051/univmed.2009.v28.133-138.

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The decision to treat a disease is often based on the presence or absence of symptoms, one prototype case being rhegmatogenous retinal detachment. Detachment of the neural retina from the pigment epithelium is a major cause of anatomical and functional dysfunction of the retina, where retinal recovery is inversely related to duration of detachment. The purpose of retinal reattachment is to effect recovery of the photoreceptors and pigment epithelium from degeneration. The aim of this study was to determine the critical duration of rhegmatogenous retinal detachment resulting in optimal retinal recovery after reattachment. A prospective study was conducted at a private hospital in Yogyakarta. Thirty five eyes were involved in this study. Three months after reattachment, central retinal recovery was measured by means of a Goldmann manual kinetic perimeter. The results showed that retinal recovery developed three months after surgery if the onset of rhegmatogenous retinal detachment was less than 28 days before surgery. The results were not significant if the onset of rhegmatogenous retinal detachment was more than 35 days. Although the Goldmann manual kinetic perimeter can efficiently detect central retinal sensitivity, it should be supported by more sensitive tools to evaluate the anatomy and function of the retina.
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Fadlia Rahmani, Nur. "Tinjauan Pustaka Retinal Detachment Pada Pediatri." Jurnal Syntax Fusion 2, no. 01 (2022): 121–26. http://dx.doi.org/10.54543/fusion.v2i01.136.

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photons then used as electrical and chemical signals for the brain to see visual images.A condition when the neurosensory retina loses attachment to the retinal pigment epithelium (RPE) is referred to as retinal detachment or retinal detachment that can result in degeneration of photoreceptors and ischemia that can cause permanent vision loss.It generally occurs in old age, but can also occur in children with a prevalence of about 0.5-8% of all retinal detachment.Retinal detachment can be classified into three, namely, rhegmatogenous retinal detachment, tractional retinal detachment and exudative retinal detachment.The procedure that can be done in the form of surgery and non-surgery, where surgery is generally done on retina regmatogeno and traction.While in the exudative retinal ablation can be done without surgery.
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Ibrar, Ahmed, Maghsoudlou Panayiotis, and El-Ashry Mohamed. "Recognising and managing retinal detachments." British Journal of Hospital Medicine 82, no. 10 (2021): 1–11. http://dx.doi.org/10.12968/hmed.2021.0145.

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Retinal detachments are a potentially sight-threatening ophthalmic emergency that may result in significant, irreversible vision loss. The risk of developing retinal detachment increases with advancing age, myopia and trauma. Pre-existing retinal degenerations can precipitate a pre-detachment symptomatic period of photopsia or floaters, allowing clinicians to intervene early and prevent detachments. Novel imaging techniques, such as spectral-domain optical coherence tomography, and well-established topographic modalities, such as B scan, can help to elucidate the type of detachment and any underlying causes, and help with surgical management. The overarching goal of treatment is to identify and seal all retinal holes, relieve vitreoretinal traction and prevent further recurrence. Prompt prophylactic retinopexy of retinal holes and tears is crucial in preventing retinal detachment, the main treatments of which are pars plana vitrectomy, tamponading agents and silicone scleral buckle.
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D, Shah. "Resolution of Bilateral Exudative Retinal Detachment Secondary to Renal Hypertension with Systemic Management." Open Access Journal of Ophthalmology 7, no. 2 (2022): 1–2. http://dx.doi.org/10.23880/oajo-16000252.

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Exudative retinal detachment (ERD) is an ocular condition, which develops from pathological conditions that disrupt the integrity of blood-retinal barrier due to fluid accumulation in sub retinal space or under neurosensory retina. Exudative retinal detachment is typically associated with inflammatory, infectious, neoplastic, and vascular pathological conditions. We report the management of bilateral exudative retinal detachment in young patients secondary to Renal Hypertension.
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Dissertations / Theses on the topic "Retinal detachment"

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Fincham, G. S. "The prevention and pathogenesis of retinal detachment." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1459426/.

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Retinal detachment contributes to nearly 500 new blind registrations in the United Kingdom each year. In contrast to other retinal blinding disorders, blindness from retinal detachment is potentially avoidable with a better understanding of the mechanisms defining sub-groups at risk of the event. The majority of retinal detachments are rhegmatogenous, resulting from retinal tears that occur during the process of posterior vitreous detachment. Posterior vitreous detachment is generally considered to be a common, age-related synchitic and syneretic degeneration of the vitreous gel. However, this current understanding fails to explain the significant number of elderly individuals who never undergo posterior vitreous detachment, or the number of young patients with co-existing intraocular pathology who do. Furthermore, the factors distinguishing the majority of patients who undergo ‘physiological’ posterior vitreous detachment (with no associated retinal tears or detachment) from the minority of patients who suffer ‘pathological’ posterior vitreous detachment (associated with retinal tears and/or detachment), remain poorly understood. The objectives of this research project were two-fold: Firstly, to investigate the hypothesis that appropriate prophylactic intervention could reduce blindness from retinal detachment if a high-risk sub-group of individuals were defined. This clinical study retrospectively evaluated a group of molecularly confirmed type 1 Stickler syndrome patients, a homogenous cohort who have been identified to carry the greatest risk of inherited retinal detachment at the time of their posterior vitreous detachment. Multiple analyses comparing patients and eyes that received prophylactic intervention with appropriate controls, consistently demonstrated that the Cambridge Prophylactic Cryotherapy protocol is safe and markedly reduces the risk of retinal detachment in type 1 Stickler syndrome. Secondly, to investigate the anatomical and cellular mechanisms of posterior vitreous detachment in the wider population. This laboratory study sought to isolate and immunohistochemically phenotype posterior hyaloid membranes and associated laminocytes from donor human globes that had undergone ‘physiological’ posterior vitreous detachment. The isolated posterior hyaloid membranes were demonsatrated to be distinct basement membranes composed of type IV collagen and laminin, and morphologically correlated with posterior hyaloid membranes observed clinically in patients presenting with posterior vitrous detachment. Furthermore, the laminocyte cell population adherent to the vitreal aspect of the posterior hyaloid membrane, was identified to express macrophage cell markers.
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Diederen, Roselie Maria Helena. "Biochemical and clinical factors in rhegmatogenous retinal detachment." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=8304.

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Woo, Tak-yunn Tiffany, and 胡德欣. "Neuroprotective strategies in a rat model of retinal detachment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48334911.

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Retinal detachment (RD) is a leading cause of blindness and although final surgical reattachment rate has greatly improved, visual outcome in many macula-off detachments is disappointing, mainly because of photoreceptor cell death. We previously showed that both lutein and Lycium barbarum polysaccharides (LBP) are neuroprotective in a rodent model of ischemia/reperfusion injury. The objective of this study is to investigate lutein and LBP as possible pharmacological adjuncts to surgery. Lutein: Subretinal injections of 1.4% sodium hyaluronate were used to induce RD in Sprague-Dawley rats until their retinae were approximately 70% detached. Daily injections of corn oil (control group) or 0.5mg/kg lutein in corn oil (treatment group) were given intraperitoneally starting 4 hours after RD induction. Animals were euthanized 3 days and 30 days after RD and their retinae were analyzed for photoreceptor apoptosis and cell survival at the outer nuclear layer (ONL) using TUNEL staining and cell counting on retinal sections. Glial fibrillary acidic protein (GFAP) and rhodopsin (RHO) expression were evaluated with immunohistochemistry. Western blotting was done with antibodies against cleaved caspase-3, cleaved caspase-8 and cleaved caspase-9 to delineate lutein’s mechanism of action in the apoptotic cascade. To seek a possible therapeutic time window, the same set of experiment was repeated with treatment commencing 36 hours after RD. When lutein was given 4 hours after RD, there was significantly fewer TUNELpositive cells in ONL 3 days after RD when compared with the vehicle group. Cell counting showed that there were significantly more nuclei in ONL in lutein-treated retinae by day 30. Treatment groups also showed significantly reduced GFAP immunoreactivity and preserved RHO expression. At day 3 after RD, Western blotting showed reduced expression of cleaved caspase-3 and cleaved caspase-8 in the treatment group. No difference was found for cleaved caspase-9. When lutein was given 36 hours after RD similar results were observed. Our results suggest that lutein is a potent neuroprotective agent that can salvage photoreceptors in rats with RD, with a therapeutic window of at least 36 hours. The use of lutein in patients with RD may serve as an adjunct to surgery to improve visual outcomes. LBP: The same RD model was used for the LBP experiment. Phosphate buffered solution (PBS) or LBP in PBS was given orally through a gavage at 1mg/kg and 10mg/kg concentrations. For this experiment, animals were sacrificed 7 days after RD, and only cell counting of the ONL and TUNEL staining were performed. Both sets of results did not produce statistically significant changes with the use of LBP. Our preliminary data for the effect of LBP on retinal detachment shows no significant beneficial effect.<br>published_or_final_version<br>Medicine<br>Master<br>Master of Research in Medicine
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Mitry, Danny. "Primary rhegmatogenous retinal detachment : clinical epidemiology and genetic aetiology." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8923.

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Primary rhegmatogenous retinal detachment (RRD) is one of the most common ophthalmic emergencies. RRD is caused by a full thickness break in the retina which initiates separation of the neurosensory retina from the underlying retinal pigment epithelium. The subsequent accumulation of fluid within this potential space extends the area of detachment and causes visual loss. Previous assessments of RRD incidence have demonstrated large differences in case definition and methodology, with incidence estimates varying 3-fold geographically and in different time periods. To date there have been no systematic or prospective incidence estimates of primary RRD in the U.K. In this thesis I present the findings of a 2-year epidemiology study that prospectively aimed to recruit all incident cases of primary RRD diagnosed in Scotland. Case recruitment from consenting participants comprised a detailed questionnaire and a blood sample. In this thesis, I present the findings of the Scottish retinal detachment study that examined the incidence, demographic features, temporal incidence trends, as well as clinical and socio-economic associations of primary RRD in Scotland. From the clinical and genetic resource I assembled, I calculated the first population based estimate of the sibling recurrence risk ratio for RRD and designed and assisted in the analysis of the first case-control genome wide association study of this condition. Results from this study have estimated the annual incidence of primary RRD in Scotland to be 12.05 per 100,000 population. Based on this estimate, there are approximately 7,300 new cases annually in the United Kingdom. RRD incidence increases with age, is more common in men and right eyes, and is strongly associated with socio-economic affluence. In addition, using hospital episode data, the overall age-standardised incidence of RRD in Scotland was shown to be steadily increasing since 1987 with an average annual increase of 1.9%. Analysis of the clinical findings highlighted that the majority of RRD cases are caused by more than one retinal break; an important consideration for appropriate surgical management. Ocular trauma, previous cataract surgery, family history, and retinal degeneration are important predisposing features. In addition, over a 2 year period approximately 7% of individuals will suffer a RRD in the fellow eye representing an important risk of bilateral visual loss. Furthermore, I demonstrate that the risk of having an affected sibling with RRD is increased 2-fold given that one sibling has had the condition, substantiating a genetic component to the pathogenesis of this condition. In the final aspect of this thesis I will present the design and analysis of a two stage case-control genome-wide association study examining the role of common genetic variants and selected candidate genes in predisposing to RRD development.
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Kirin, Mirna. "Genetic analysis of retinal traits." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9619.

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Retina is a unique site in the human body where the microcirculation can be imaged directly and non-invasively, allowing us to study in vivo the structure and pathology of the human microcirculation. Retinal images can be quantitatively assessed with computerized imaging techniques, enabling us to measure several different quantitative traits derived from the retinal vasculature. Arterial and venular calibres are the most extensively studied traits of the retinal microvasculature and numerous epidemiological studies demonstrated promising associations with systemic and ocular diseases as well as with disease markers. However, there has been a lack of research into pathophysiological processes leading to retinal vascular signs, and how they link retinal microcirculation with coronary and cerebral microvasculature change. Information about genetic determinants underlying retinal vascular structure is therefore important for understanding the processes leading to microvascular pathophysiology. Two genome wide association studies have been published so far revealing four loci associated with retinal venular calibre and one locus with arteriolar calibre. Here the results from the genome-wide association analysis of 10 different retinal vessel traits in two population based cohorts are presented. Retinal images were measured in non-mydriatic fundus images from 808 subjects in the Orkney Complex Disease Study (ORCADES) and 390 subjects from the Croatian island of Korcula, using the semi-automated retinal vasculature measurement programme SIVA and VAMPIRE. Using pairwise estimates of kinship based on genomic sharing, heritability was calculated for each trait. Estimates of tortuosity measure and fractal dimensions present first published reports of heritability estimates for those traits. In addition correlation analysis with systemic risk factor was also completed, confirming already published results as well as revealing some new associations. A genome wide association analysis of retinal arteriolar width revealed a genome wide significant hit (1.8x10-7) in a region of chromosome 2q32 (within TTN gene). Replication was sought in a further independent Scottish population (LBC) and additional 400 retinal images were graded. The result did not replicate, however the direction of the effect was consistent and a larger sample size is required. Analysis of the remaining traits did not yield genome wide significant result,s and will also require larger sample sizes. Genetic analysis of a binary retinal trait was also explored in a case control study of retinal detachment, which is an important cause of vision loss. A two-stage genetic association discovery phase followed by a replication phase in a combined total of 2,833 RRD cases and 7,871 controls was carried out. None of the SNPs tested in the discovery phase reached the threshold for association. Further testing was carried out in independent case-control series from London (846 cases) and Croatia (120 cases). The combined meta-analysis identified one association reaching genome-wide significance for rs267738 (OR=1.29, p=2.11x10-8), a missense coding SNP and eQTL for CERS2 encoding the protein ceramide synthase 2. Additional genetic risk score, pathway analysis and genetic liability analysis were also carried out.
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Chandra, A. "The genetic associations of rhegmatogenous retinal detachment and ectopia lentis." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1419863/.

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A genetic predisposition to Rhegmatogenous Retinal Detachment (RD) has been suggested for over 40 years. Ectopia Lentis (EL) is known to have a genetic aetiology as part of Marfan Syndrome, other ocular syndromes and when occurring in isolation. This work investigates the genetic aetiology to these conditions in Mendelian and non Mendelian inheritance. The work in this thesis establishes a clear genotype-phenotype correlation between isolated EL and its most important causative gene: ADAMTSL4. This suggests that mutations in this gene result in a more severe phenotype than other genes causing EL. In doing so, a novel clinical grading system for this condition has also been developed. The expression of ADAMTSL4 and distribution of its protein within ocular tissue has also been investigated and suggests further roles for this protein in ocular development. Modelling of the protein was undertaken and provides insights for future investigations. Traditional and novel next generation investigative tools have also been employed to examine families with Mendelian inherited phenotypes including RD and EL. The role of a deleted exon in ADAMTS17 has been identified as playing a role in Weill-Marchesani Like syndrome. A novel ocular phenotype has also been defined in three families demonstrated to be caused by mutations in ADAMTS1 8. This gene has previously been described in few probands with ophthalmic phenotypes, and this work has further delineated the role of this gene. It is becoming clear that members of the ADAMTS family of proteins play a significant role in ocular development. Finally, over 1300 probands with non-Mendelian RD were recruited and closely phenotyped as part of this work. It has demonstrated novel racial differences in the phenotypes of those affected. This cohort contributed significantly towards the first genome wide association study (GWAS) into RD; and established for the first time the genetic contribution to this condition. Further funding has now been acquired to investigate this cohort further using a novel exome array. Preliminary quality control analysis has been performed; allowing a platform for further detailed analysis to identify putative functional variants associated with RD.
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Ranta, Päivi. "Retinal detachment after neodymium : yttrium-aluminum-garnet laser posterior capsulotomy." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/ranta2/.

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Parks, Stuart William. "Electroretinographic mapping of retinal function : evaluation and clinical application." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341750.

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Dallacasagrande, Valentina. "Novel approaches to study the biomechanics of intact central nervous tissue." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-163943.

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In nature, cells are not randomly clustered to form tissues. The tissue is a more complicated system with functions that go beyond what any single cell type could accomplish. While studying single-cell mechanics and dynamics is relevant from an investigative point of view, this approach loses, or fail to gather information about the tissue. The tissue investigated in this study is the neurosensory retina which seeing as extension of the brain is a very convenient model for the central nervous system due to its accessibility. The retina is constantly subjected to different mechanical stresses from development to adulthood. Although the majority of the phenomena where mechanical stresses are involved are well-studied, the mechanics behind them is not well understood. However, knowledge about the ability of the retina to adjust to mechanical stresses is essential, for example, for improving retinal surgery. Establishing a method to mechanically probe the retina is a challenge due to the extremely delicate nature of this multilayered neural tissue and to the short-time survival ex vivo. The organotypic tissue culture is a powerful tool because it allows to maintain with high accuracy the complex multicellular anatomy and the microenvironment of the original tissue. One of the limitations of the organotypic culture techniques has been until recently due to the ability to use only post-natal/juvenile tissues for long-term culture. The importance of using adult tissue is incontestable when the investigation focuses on age-related pathologies such as vitreous shrinkage or macula degeneration. In this work, TiO2 nanotube arrays are presented as the innovative substrate for long-term organotypic culture of adult neural tissue. The retinal whole-mount of adult guinea pig and the brain slices of adult mouse were cultures for 14 days without showing any sign of edema or swelling. Furthermore, in order to study the behavior of the retinal tissue under shear stress new set-ups were designed. For the first time, the behavior of the retinal layers were observed showing that the retina does not act as an homogeneous material in response to an applied stress. The methods developed here can be used for future quantitative studies, to provide an exact knowledge of retinal biomechanics which will help retinal surgeons to optimize their methods.
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Takasaka, Iuuki 1980. "Ensaio clínico aleatorizado de crioterapia intra-operatória versus fotocoagulação pós-operatória a laser para retinopexia na cirurgia de introflexão escleral." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311824.

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Orientadores: Rodrigo Pessoa Cavalcanti Lira, Carlos Eduardo Leite Arieta<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-20T06:50:41Z (GMT). No. of bitstreams: 1 Takasaka_Iuuki_M.pdf: 2254339 bytes, checksum: 4a21730e60893b2777df71653d5f38c2 (MD5) Previous issue date: 2012<br>Resumo: Introdução: O descolamento de retina regmatogênico (DRR), uma das causas de cegueira, tem uma incidência anual de cerca de 6,3 - 17,9/100.000 habitantes na população mundial, e se não tratado pode levar a cegueira devido a degeneração das camadas retinianas. O uso de introflexão em conjunto com as adesões coriorretinianas em torno da rotura retiniana forma a base do tratamento para muitos DRR simples. A crioterapia realizada para retinopexia intra-operatoria tem sido implicada no desenvolvimento de pucker macular e vitreorretinopatia proliferativa. Eliminar a crioterapia da cirurgia convencional de introflexão poderia não afetar o resultado do sucesso anatômico e melhorar a recuperação visual. Objetivo: O objetivo primário deste ensaio clínico randomizado foi comparar a taxa de reaplicação retiniana e secundariamente os resultados da acuidade visual em pacientes com DRR que se submeteram a cirurgia de introflexão escleral e retinopexia com a crioterapia intra-operatória versus fotocoagulação a laser pós-operatório (um mês após a cirurgia). Método: É um ensaio clínico aleatorizado, mascarado, realizado em um único centro, composto por 86 pacientes submetidos à cirurgia de introflexão escleral. Os pacientes foram aleatorizados para serem submetidos à cirurgia de introflexão escleral e retinopexia com crioterapia intraoperatória (criopexia) ou retinopexia com fotocoagulação a laser pós operatória de 30 dias (laserpexia) após o procedimento. O desfecho primário foi avaliar a taxa de reaplicação retiniana no seguimento pós-operatório em 1 semana. Os desfechos secundários foram avaliar as taxas de reaplicação retiniana, as taxas de reoperação, as taxas de complicações pós-operatórias e recuperação da acuidade visual, em 1 mês e 6 meses de seguimento pós-operatório. Resultados: Foram incluídos 86 olhos de 86 pacientes a serem submetidos introflexão escleral. A amostra foi constituída de 43 pacientes pertencentes ao grupo laserpexia e 43 pacientes atribuídos ao grupo criopexia. Os dados demográficos foram semelhantes nos dois grupos. A taxa de sucesso anatômico em 1 semana, 1 mês e 6 meses foram semelhantes nos dois grupos, respectivamente, 93% (40 pacientes), 100% e 100% no grupo criopexia e 95,3% (41 pacientes), 100% e 100% no grupo da laserpexia (P, respectivamente, 0,5; 1,0 e 1,0). Três pacientes do grupo criopexia e 2 do laserpexia foram submetidos a uma cirurgia adicional (vitrectomia via pars plana) após a falha primária em 1 semana de seguimento. As complicações pós-operatórias foram semelhantes nos dois grupos, com exceção do edema de pálpebras. A recuperação visual foi mais lenta no grupo da crioterapia. A diferença na AV após 6 meses não foi significativa. Conclusão: Em pacientes com descolamento de retina regmatogênico sem complicações, ambas as técnicas de retinopexia mostraram resultados anatômico e funcional satisfatórios. A opção por laserpexia oferece recuperação visual mais rápida com menos complicações, porém requer uma segunda intervenção e maior custo em relação a criopexia<br>Abstract: Introduction: Rhegmatogenous retinal detachment (RRD), one of causes of blindness, has an annual incidence of about 6.3 to 17.9/100.000 people in the world population, and if untreated can lead to blindness due to degeneration of the retinal layers. The use of scleral buckles combined with chorioretinal adhesions around the retinal tear forms the basis of treatment for many simple RRD. Cryotherapy for retinopexy performed intraoperatively has been implicated in the development of macular pucker and proliferative vitreoretinopathy. Eliminating cryotherapy of conventional surgery might not affect the outcome of anatomic success and improve visual recovery. Objective: The aim of this randomized clinical trial was to compare the rate of retinal reapplication and secondly the results of visual acuity in patients with rhegmatogenuos retinal detachment who underwent surgery with scleral buckle retinopexy and intraoperative cryotherapy versus laser photocoagulation postoperatively (one month after surgery). Method: A randomized, masked, performed in a single center, comprising 86 patients undergoing scleral buckle surgery. Patients were randomized to undergo surgery, scleral buckle retinopexy with cryotherapy and intraoperative (criopexy) or postoperative retinopexy with photocoagulation 30 days (laserpexy) after the procedure. The primary endpoint was to evaluate the rate of replication in retinal postoperative follow-up within 1 week. Secondary endpoints were to evaluate retinal reapplication rates, reoperation rates, rates of postoperative complications and recovery of visual acuity at 1 month and 6 months postoperative follow-up. Results: We included 86 eyes of 86 patients undergoing scleral buckle. The sample consisted of 43 patients belonging to the group laserpexy and 43 patients assigned to the group criopexy. Demographic data were similar in both groups. The anatomic success rate in 1 week, 1 month and 6 months were similar in both groups, respectively, 93% (40 patients), 100% and 100% in criopexy and 95.3% (41 patients), and 100% 100% in group laserpexy (P, respectively, 0.5, 1.0 and 1.0). Three patients of group criopexy and 2 of laserpexy underwent additional surgery (pars plana vitrectomy) after the primary failure at 1-week follow-up. The postoperative complications were similar in both groups, except for edema of the eyelids. The visual recovery was slower in the cryotherapy group. The difference in VA after 6 months was not significant. Conclusion: In patients with uncomplicated rhegmatogenuos retinal detachment, both techniques of retinopexy showed satisfactory anatomical and functional results. The choice of laserpexy offers faster visual recovery with fewer complications, but requires a second intervention and higher cost compared to criopexy<br>Mestrado<br>Oftalmologia<br>Mestre em Ciências Médicas
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Books on the topic "Retinal detachment"

1

1935-, McLean Edward B., and Chuang Elaine L. 1952-, eds. Retinal detachment. 5th ed. American Academy of Ophthalmology, 1989.

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2

P, Wilkinson Charles, Rice Thomas A, and Hengst Timothy C, eds. Retinal detachment. Mosby, 1990.

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Retinal detachment surgery. 2nd ed. Springer-Verlag, 1988.

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Hilton, George F. Retinal detachment: Principles and practice. 2nd ed. American Academy of Ophthalmology, 1995.

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Wilkinson, Charles P. Michels's retinal detachment. 2nd ed. Mosby, 1997.

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Blind, Royal National Institute for the. Understanding retinal detachment. RNIB, 2001.

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Chignell, A. H. Retinal Detachment Surgery. Springer London, 1988. http://dx.doi.org/10.1007/978-1-4471-1621-9.

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Kreissig, Ingrid, ed. Primary Retinal Detachment. Springer-Verlag, 2005. http://dx.doi.org/10.1007/b138106.

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Brinton, Daniel A. Retinal detachment: Principles and practice. 3rd ed. Oxford University Press in cooperation with the American Academy of Ophthalmology, 2009.

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Retinal detachment: Diagnosis and management. 2nd ed. Lippincott, 1988.

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Book chapters on the topic "Retinal detachment"

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Wolf, Armin, Anselm Kampik, and Thomas Kohnen. "Retinal Detachment." In Encyclopedia of Ophthalmology. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-35951-4_421-3.

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Yoshimura, Nagahisa, and Masanori Hangai. "Retinal detachment." In OCT Atlas. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-38625-1_10.

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Galloway, N. R. "Retinal Detachment." In Common Eye Diseases and their Management. Springer London, 1985. http://dx.doi.org/10.1007/978-1-4471-3521-0_12.

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Galloway, Nicholas Robert, and Winfried Mawutor Kwaku Amoaku. "Retinal Detachment." In Common Eye Diseases and their Management. Springer London, 1999. http://dx.doi.org/10.1007/978-1-4471-3625-5_13.

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Spandau, Ulrich, and Mitrofanis Pavlidis. "Retinal Detachment." In 27-Gauge Vitrectomy. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20236-5_13.

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Spandau, Ulrich, and Heinrich Heimann. "Retinal Detachment." In Practical Handbook for Small-Gauge Vitrectomy. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23294-7_10.

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Dirani, Ali, and Thomas J. Wolfensberger. "Retinal Detachment." In Spectral Domain Optical Coherence Tomography in Macular Diseases. Springer India, 2016. http://dx.doi.org/10.1007/978-81-322-3610-8_21.

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Wolf, Armin, Anselm Kampik, and Thomas Kohnen. "Retinal Detachment." In Encyclopedia of Ophthalmology. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-540-69000-9_421.

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Galloway, Nicholas R., Winfried M. K. Amoaku, Peter H. Galloway, and Andrew C. Browning. "Retinal Detachment." In Common Eye Diseases and their Management. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32869-0_13.

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Galloway, Nicholas R., Winfried M. K. Amoaku, Peter H. Galloway, and Andrew C. Browning. "Retinal Detachment." In Common Eye Diseases and their Management. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08450-8_13.

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Conference papers on the topic "Retinal detachment"

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Rusovici, R., D. Dalli, K. Mitra, M. Calhoun, R. Mazzocchi, and M. Grace. "Design of Retinal Stent Using Finite Element Analysis." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14477.

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The retina is a light-sensitive tissue layer that lines the inside of the eye and relays visual information directly to the brain via the optic nerve. Retinal detachment occurs when the retina is lifted or pulled from its physiological location. This condition can result in partial or total vision loss. Retinal detachmentis a leading cause of permanent vision loss.
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Rubin, Gary S., and Brian C. Lerner. "Contrast Sensitivity and Vernier Acuity After Resolution of Central Serous Chorioretinopathy." In Noninvasive Assessment of the Visual System. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/navs.1987.wd2.

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Central serous chorioretinopathy (CSCR) is a macular disease which predominately affects males 25 to 50 years of age. The disease is characterized by one or more focal defects or detachments of the retinal pigment epithelium (RPE) with a serous detachment of the overlying sensory retina. Visual symptoms include blurred vision, scotoma, metamorphopsia, micropsia, and color vision abnormalities. The patients frequently have reduced acuity, though seldom worse than 20/70.
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Yadav, Sonal, Navin Kumar Roy, Nishant Sharma, and R. Murugan. "Classification of Retinal Detachment using Deep Learning through Retinal Fundus Images." In 2022 IEEE India Council International Subsections Conference (INDISCON). IEEE, 2022. http://dx.doi.org/10.1109/indiscon54605.2022.9862901.

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Paralejas, Aram Joie L., and Maricar A. Garcia. "Degenerative Myopia with Macular Thinning and Retinal Window Defect: A Stage Before Retinal Detachment." In 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019). Atlantis Press, 2020. http://dx.doi.org/10.2991/ahsr.k.200523.068.

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Ren, Qiushi, Gabriel Simon, Jean-Marie A. Parel, Yoshiko Takesue, Jin-Hui Shen, and William E. Smiddy. "Laser scleral buckling: a new method to treat retinal detachment." In OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, edited by Jean-Marie A. Parel and Qiushi Ren. SPIE, 1993. http://dx.doi.org/10.1117/12.147538.

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Mattioli, Stefano. "0204 Retinal detachment and occupational lifting: the evidence to date." In Eliminating Occupational Disease: Translating Research into Action, EPICOH 2017, EPICOH 2017, 28–31 August 2017, Edinburgh, UK. BMJ Publishing Group Ltd, 2017. http://dx.doi.org/10.1136/oemed-2017-104636.162.

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Morimoto, David, Kathleen M. Keehan, Paul E. Kilbride, and Norman P. Blair. "Retinal Reattachment of the Human Macula Assessed by Imaging Fundus Reflectometry." In Noninvasive Assessment of the Visual System. Optica Publishing Group, 1990. http://dx.doi.org/10.1364/navs.1990.tha4.

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Visual recovery following retinal reattachment surgery may be limited by a number of factors. Detachment of the macula is the most important of these, often yielding poor visual acuity after an anatomic success. Gross morphologic changes giving a poor visual result include macular pucker, cellophane maculopathy, cystoid macular edema, and subretinal fibrosis. Some cases with a normal appearing macula by ophthalmoscopy have reduced visual acuity, and these have been attributed to misalignment of photoreceptors, faulty regeneration of photoreceptors, or RPE atrophy (4,5,6). Histologic animal studies have shown degeneration of photoreceptor outer segments following retinal detachment with gradual regeneration following reattachment (2,8). In this report we use fundus reflectometry in vivo to compare the spatial distribution of the visual pigments, contained in photoreceptor outer segments, in 3 patients following retinal reattachment surgery with 9 controls.
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Gupta, Rajeev, Pramod Kumar Singh, Basant Kumar, Abhishek Singh, and Ayushi Chandra. "Automated Detection of Retinal Detachment from Ocular Ultrasound using Image Thresholding." In 2018 5th International Conference on Signal Processing and Integrated Networks (SPIN). IEEE, 2018. http://dx.doi.org/10.1109/spin.2018.8474245.

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Rossi, Tommaso, Giorgio Querzoli, Rodolfo Repetto, et al. "In-Vivo Measurement of Vitreous Motion Using an Ultrasound Imaging Velocimetry Technique." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80563.

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Vitreous dynamics plays a fundamental role in the pathogenesis of various vitreo-retinal diseases, such as vitreous haemorrhage, peripheral retinal degeneration and tears, retinal detachment,… Quantitative measurement of vitreous motion has been attempted in the past using ultrasound imaging [1] and MRI [2]. However, information about vitreous motion secondary to eye rotations as well as knowledge of vitreous rheology is still limited.
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Johnson, Mary A., and Daniel Finkelstein. "The Electroretinogram in Ischemic Retinopathies." In Noninvasive Assessment of the Visual System. Optica Publishing Group, 1986. http://dx.doi.org/10.1364/navs.1986.mc3.

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Retinal or iris neovascularization (NV) is a complication of diabetic retinopathy, branch and central vein occlusion, Eale’s disease, sickle cell retinopathy, and other retinal-vascular disorders which have as their common element extensive retinal capillary non-perfusion. This vascular proliferation is thought to occur as a response to the reduced retinal perfusion. The new vessels, however, do not grow normally and because of this, place the patient at risk for severe visual loss due to vitreous hemmorhage and/or fractional retinal detachment, or in the case of irisneovascularization (rubeosis), acute (closed-angle) glaucoma.
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Reports on the topic "Retinal detachment"

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Chen, Chen, Peng Chen, Xia Liu, and Hua Li. Combined 5-Fluorouracil and Low Molecular Weight Heparin for the Prevention of Postoperative Proliferative Vitreoretinopathy in Patients with Retinal Detachment. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.8.0117.

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Review question / Objective: The aim of this meta-analysis is to evaluate the efficacy and safety of intraoperative infusion of combined 5-fluorouracil and low molecular weight heparin (LMWH) for the prevention of postoperative proliferative vitreoretinopathy in patients with retinal detachment. Condition being studied: Postoperative proliferative vitreoretinopathy (PVR) is the primary cause of failure of retinal reattachment surgery. 5-fluorouracil (5-FU) inhibits the proliferation of fibroblasts, and suppresses collagen contraction. On the other hand, heparin reduces fibrin exudation, and inhibits the adhesion and migration of retinal pigment epithelial cells. We conduct this comprehensive literature search and meta-analysis to address whether intraoperative infusion of combined 5-FU and LWMH improves the primary success rate of pars plana vitrectomy, as well as reduces postoperative PVR. Our study aims to provide clinical evidence for retinal surgeons concerning their choice of intraoperative medication.
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Jiang, yang, and shixin Qi. Diagnostic test accuracy of spectral-domain optical coherence tomography used to Differentiate PCV from nvAMD and other diseases that tend to cause serous or serosanguinous retinal pigment epithelial detachment: a systematic review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.12.0048.

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