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1

Ribeiro, Maria Cecilia Menks. "Aspectos citogeneticos do retinoblastoma." São Paulo (SP), 1988. https://repositorio.ufsc.br/handle/123456789/106296.

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2

Walther, Jan. "Efficient Photodynamic Therapy on Human Retinoblastoma Cell Lines." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-169627.

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Die Photodynamische Therapie (PDT) hat sich zunehmend als vielversprechende Methode zur Behandlung von verschiedenen malignen Neubildungen gezeigt. Die photodynamische Zerstörung der Tumore wird erreicht indem zunächst ein Photosensibilisator entweder lokal oder systemisch appliziert wird und im Anschluss an eine gewisse Inkubationszeit die Tumormasse mittels einer Lichtquelle mit einer spezifischen Wellenlänge durchleuchtet wird. Aufgrund der bevorzugten Anreicherung des Photosensibilisators in Tumorzellen, erlaubt diese Methode eine selektive Abtötung des malignen Tumors, während das umliege
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3

Walther, Jan, Stanislas Schastak, Sladjana Dukic-Stefanovic, Peter Wiedemann, Jochen Neuhaus, and Thomas Claudepierre. "Efficient photodynamic therapy on human retinoblastoma cell lines." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-148182.

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Photodynamic therapy (PDT) has shown to be a promising technique to treat various forms of malignant neoplasia. The photodynamic eradication of the tumor cells is achieved by applying a photosensitizer either locally or systemically and following local activation through irradiation of the tumor mass with light of a specific wavelength after a certain time of incubation. Due to preferential accumulation of the photosensitizer in tumor cells, this procedure allows a selective inactivation of the malignant tumor while sparing the surrounding tissue to the greatest extent. These features and requ
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4

Kleinerman, Ruth. "Second cancers following treatment for retinoblastoma." Thesis, City, University of London, 2016. http://openaccess.city.ac.uk/17330/.

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Improvements in treatment over the past century have greatly increased survival for retinoblastoma, a rare childhood tumour of the eye, caused by mutations of the RB1 tumour suppressor gene. However, as survival for retinoblastoma has improved, those with the hereditary form of the disease (RB1 germline mutation) have elevated risks of developing additional cancers, mostly bone and soft tissue sarcomas and melanoma. Despite advances in understanding of second cancer risks following treatment for retinoblastoma, key research questions remained including 1) risks of common adult onset cancers, s
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5

Lillington, Debra Mia. "The investigation of genomic imbalance in retinoblastoma." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499104.

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6

Chew, Yat Peng. "Regulation of the retinoblastoma protein by phosphorylation." Thesis, Institute of Cancer Research (University Of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391767.

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7

Sefta, Meriem. "Comprehensive Molecular and Clinical Characterization of Retinoblastoma." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS074/document.

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Le rétinoblastome est un cancer pédiatrique rare de la rétine en cours de développement. Si dans les pays développés, le taux de survie avoisine 100%, une énucléation de l’oeil atteint est cependant nécessaire dans plus de 70% des cas.En 1971, Knudson émit l’hypothèse des deux “hits”, qui permit de comprendre que le rétinoblastome s’initie généralement après une perte bi-allélique du gène RB1. Cependant, les autres mécanismes moléculaires qui régissent ce cancer restent depuis peu connus. Par exemple, peu d’études génomiques ont été conduites. Ainsi, la nature de la cellule d’origine, ainsi qu
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8

Côté, Richard Gaston. "Characterization of the retinoblastoma binding protein 2 (RBP2)." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33388.

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The retinoblastoma (RB) family of proteins plays a pivotal role in cell cycle regulation. Its members, p105/Rb, p107 and p130, interact with the E2F and DP family of transcription factors to regulate transcription of essential cell cycle and DNA synthesis genes. Several reports have mapped the regulation of E217 by RB family members to the "pocket" domain of these proteins. We demonstrate here that RBP2, a pocket-binding protein that encodes multiple DNA-binding and protein-protein interaction domains, is a transcriptional repressor. Overexpression of RBP2 inhibits E2F-dependent transcription
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9

Inche, Adam. "The post translational modification of the retinoblastoma protein." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491620.

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The retinoblastoma protein (pRb) is a central figure in the control of not only the cell cycle, but also other cellular functions such as differentiation. The regulation of pRb function is through a variety of post translational modifications, either on pRb itself, or by the controlling influence of pRb on the post translational modification of the histone proteins. Phosphorylation of pRb is a key mechanism in the regulation of the cell cycle. pRb is also involved in the recruitment of histone methyltransferase (HMT) and acetyltransferase (HAT) to the chromatin to modify histones. Previous wor
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10

Markham, Douglas James. "Acetylation control of the retinoblastoma tumour suppressor protein." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433229.

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11

Kogishi, Junichi. "Mutant herpes simplex virus-mediated suppression of retinoblastoma." Kyoto University, 1999. http://hdl.handle.net/2433/181258.

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12

Ferguson, Kerry L. "The role of the retinoblastoma protein in cortical neurogenesis." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/29105.

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The retinoblastoma (Rb) protein was known to be a critical cell cycle regulator in tumour cells, however, little was known regarding its role in normal neural development. To determine the importance of the Rb signalling pathway in neural precursor proliferation and differentiation, I first characterized the key cell cycle regulators and examined the requirement for Rb in these processes. In contrast to previous studies, dominant negative CDK4/6 mutants induced mitotic arrest in neural precursors, despite the binding and sequestration of the Cip/Kip CKIs, p21Cip1 and p27 Kip1. The activity of
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13

Burcescu, Irina D. "The role of the retinoblastoma protein in retinal development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63095.pdf.

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14

Vooijs, Marc Antoine Gijsbert Gilles. "Tumor modeling in mice with conditional retinoblastoma gene deficiency." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/60982.

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15

Kennett, Jennifer Yvonne. "Molecular genetic characterization of retinoblastoma tumors lacking RB1 mutations." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43791.

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Retinoblastoma is a rare childhood cancer of the retina and is the most common intraocular tumor in children. Classically, retinoblastoma results from biallelic loss of the RB1 tumor suppressor gene. As with other cancer types, dysregulation of a single gene alone is not considered sufficient for complete transformation to malignancy. Frequent regions of genetic alteration harbouring additional genes, implicated in retinoblastoma oncogenesis and progression, include chromosomes 1q, 2p, 6p, 13q and 16q. Sensitive molecular genetic screening techniques are capable of identifying RB1 mutations in
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16

Wilkie, Scott. "Effects of sustained retinoblastoma protein activity in tumour cells." Thesis, Institute of Cancer Research (University Of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252306.

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17

Krützfeldt, Maja Susanne. "The functioning of the retinoblastoma protein in gene activation." Thesis, Institute of Cancer Research (University Of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401726.

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18

Lipinski, Marta M. (Marta Monika) 1971. "The retinoblastoma gene family in tumor suppression and development." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8317.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, February 2002.<br>Includes bibliographical references.<br>The retinoblastoma tumor suppressor and the closely related p107 and p130 proteins play important roles in the regulation of both tumorigenesis and tissue-specific differentiation. To determine the role of Rb in development more precisely, we analyzed chimeric embryos and adults made with marked Rb-/- cells. We demonstrated that although brains of chimeric embryos exhibited extensive ectopic S-phase entry, unlike in germline Rb-/- littermates, in these chimeras th
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19

Hilgendorf, Keren Ita. "The role of the retinoblastoma protein in mitochondrial apoptosis." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83766.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2013.<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>The retinoblastoma protein (pRB) tumor suppressor is deregulated in the vast majority of human tumors. pRB is a well-established transcriptional co-regulator that influences many fundamental cellular processes. It has been most well characterized in its ability to block cell proliferation by inhibiting the E2F family of transcription factors. Importantly, pRB also plays a pivotal role in apoptosis. This function has been exten
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20

Santos, Leticia Rielo de Moura [UNIFESP]. "Expressão imuno-histoquímica da proteína C-kit no Retinoblastoma." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9626.

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Made available in DSpace on 2015-07-22T20:50:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-09-30. Added 1 bitstream(s) on 2015-08-11T03:25:58Z : No. of bitstreams: 1 Publico-11857a.pdf: 776003 bytes, checksum: 706bab397cf90eafbc8d7328214672da (MD5). Added 1 bitstream(s) on 2015-08-11T03:25:59Z : No. of bitstreams: 2 Publico-11857a.pdf: 776003 bytes, checksum: 706bab397cf90eafbc8d7328214672da (MD5) Publico-11857b.pdf: 2062339 bytes, checksum: 8d0ca9b3ac4476504ad8de27d8b090d1 (MD5). Added 1 bitstream(s) on 2015-08-11T03:25:59Z : No. of bitstreams: 3 Publico-11857a.pdf: 776003
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21

A, Jamal A. Rahman Bin. "Analysis of gene rearrangement and protein expression of the tumour suppressor genes RB and P16 in patients with acute myeloid leukaemia : possible roles in leukaemogenesis leukaemia." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362773.

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22

Chapman, Robert Macdonald. "Investigation of the chromosome 13 band q14 lesions in B-cell chronic lymphocytic leukaemia : evidence for a novel tumour suppressor gene." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242548.

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23

Salustiano, Luciana Ximenes. "Fatores histopatológicos e moleculares em retinoblastomas enucleados." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3247.

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24

Bergseid, Jacqueline. "Biological function of the LxCxE-binding pocket of retinoblastoma protein." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3244732.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed February 23, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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25

Clark, Alysen. "The Role of the Retinoblastoma Protein in Dentate Gyrus Development." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23742.

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New neurons continue to be added to the dentate gyrus (DG) throughout adulthood and enhancing neurogenesis in this region holds therapeutic potential. However, the molecular mechanisms underlying DG neurogenesis remain elusive. Since developmental and adult neurogenesis often share the same signaling pathways, understanding how the DG develops is crucial to understanding adult neurogenesis. This study aims to determine the role of the retinoblastoma (Rb) protein in DG development and to determine if modulation of this pathway holds potential for enhancing neurogenesis in an adult system. A
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26

Zarkowska, Tamara Anna. "Phosphorylation of the retinoblastoma protein, pRB, by CDK4-cyclin D1." Thesis, Institute of Cancer Research (University Of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321951.

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27

Tarlton, John Francis. "Molecular mechanisms and therapies in metastatic retinoblastoma and other malignancies." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246281.

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28

任峰 and Feng Ren. "Immunoneurobiological studies of retinal ganglion neuronotrophic factor and its application in experimental treatment ofretinoblastoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31233867.

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29

Ren, Feng. "Immunoneurobiological studies of retinal ganglion neuronotrophic factor and its application in experimental treatment of retinoblastoma /." Hong Kong : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13637605.

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30

Ledl, Andreas. "Posttranslationale Modifikation des Retinoblastoma Tumorsuppressors mit dem Ubiquitin-ähnlichen SUMO Protein." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-56235.

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31

Runnacles, Elizabeth. "Analysis of stress induced retinoblastoma protein activation using an SiRNA screen." Thesis, Institute of Cancer Research (University Of London), 2009. http://publications.icr.ac.uk/10166/.

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Activation of the retinoblastoma protein (RB), by stresses such as ionizing radiation (IR) or hypoxia, causes a cell cycle arrest and has been suggested to convey therapeutic resistance to cancer cells. To investigate the cell signaling networks mediating RB activation, with the aim of uncovering potential targets for sensitisation of cancer cells, I developed and carried out a high-throughput RNA interference screen of the Dharmacon kinome-covering small interfering (si)RNA library. This identified seven siRNA gene targets required for RB activation in response to ionizing radiation; PRPK, PR
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32

MARKEY, MICHAEL PATRICK. "TRANSCRIPTIONAL REGULATION BY THE RETINOBLASTOMA TUMOR SUPPRESSOR: NOVEL TARGETS AND MECHANISMS." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1092243630.

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33

Bosco, Emily E. "The Retinoblastoma Tumor Suppressor Modifies the Therapeutic Response of Breast Cancer." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147202417.

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34

Markey, Michael P. "Transcriptional regulation by the retinoblastoma tumor suppressor novel targets and mechanisms /." Cincinnati, Ohio : University of Cincinnati, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1092243630.

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35

Ottaviani, Daniela. "In-Depth Characterization of Human Retinoblastoma Subtype 2 and Preclinical Models." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS001.

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Le rétinoblastome, un cancer pédiatrique de la rétine en développement, est la tumeur intraoculaire la plus fréquente chez l’enfant et représente environ 4 % de tous les cancers infantiles. Bien qu'il s'agisse d'une maladie rare, l'hôpital Curie (centre de référence pour le rétinoblastome en France) accueille environ 50 à 60 nouveaux patients chaque année. Notre groupe a précédemment caractérisé deux sous-types de rétinoblastomes. Les tumeurs de type « cone-like » ou sous-type 1 sont plutôt différenciées et homogènes, présentent une surexpression des gènes liés aux cellules cônes (photorécepte
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36

Selistre, Simone Geiger de Almeida. "Caracterização de pacientes com diagnóstico de retinoblastoma identificados nos Serviços de Oncologia Pediátrica, Oftalmologia e Genética no Hospital de Clínicas de Porto Alegre/RS." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/87184.

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Retinoblastoma (Rb) é o tumor ocular mais frequente na infância e cada grande Centro deve conhecer o perfil dos seus pacientes. Foi realizado um estudo do tipo coorte retrospectivo e incluiu pacientes com Rb atendidos entre 1983 e 2012 nos Serviços de Oncologia Pediátrica, Oftalmologia e Genética Médica do Hospital de Clínicas de Porto Alegre (HCPA). De um total de 165 registros no período foram efetivamente incluídos 140 pacientes, sendo 95,0% destes provenientes de municípios do Rio Grande do Sul. Os sinais mais frequentes ao diagnóstico foram: leucocoria (73,6%) e estrabismo (20,7%). Identi
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37

Fagan, Richard Joseph. "Regulation of ornithine-[delta]-aminotransferase in retinoblastomas." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70324.

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Ornithine Aminotransferase (OAT) is expressed at high levels in liver, kidney, and retina. Tissue-specific regulation of OAT has been described for rat kidney and liver. To characterize OAT regulation in retinal lines, we studied OAT synthesis in retinoblastomas RB355 and Y79.<br>OAT transcription and mRNA levels in the two lines were similar, but 3-fold greater immunoreactive OAT protein and enzyme activity were observed for Y79. Characterization of polysome-associated OAT mRNAs indicated that they were translated less efficiently, due to decreased initiation, in RB355. Initiation factor eIF-
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38

Nalabothula, Narasimharao. "Biochemical and biophysical characterization of the retinoblastoma protein and its interacting partners." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971863628.

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39

Michaels, Samantha T. M. D. "Selective Intra-Ophthalmic Artery Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415626121.

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40

Chan, Ho Man. "Molecular basis of cell cycle control : p300 and pRb." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326430.

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41

Triviño, Palomares Emma. "Estudi citogenètic i molecular de pacients afectes de retinoblastoma esporàdic i familiar." Doctoral thesis, Universitat Autònoma de Barcelona, 2001. http://hdl.handle.net/10803/3732.

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El Retinoblastoma és el tumor intraocular maligne més freqüent en l'edat pediàtrica, amb una incidència d'entre 1/16.000 i 1/25.000 nascuts vius. És hereditari en el 40% dels casos, amb una segregació de caràcter autosòmic dominant, i no hereditari en el 60%.<br/>Per a determinar si un pacient presenta la forma hereditària o no hereditària de la malaltia, cal un diagnòstic genètic, pel que l'objectiu principal d'aquest treball va ser l'establiment d'un protocol de diagnòstic addient.<br/>Es va realitzar un estudi citogenètic i d'hibridació in situ fluorescent, i un estudi molecular, utilitzant
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42

Boyce, Stephen A. "The role of the retinoblastoma gene in liver regeneration, polyploidisation and hepatocarcinogenesis." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/25341.

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To determine the role of Rb in the regulation of hepatocyte replication, two models of liver regeneration were developed. The first involved the use of carbon tetrachloride, a liver-specific toxin, to cause necrosis. The second involved performing a partial hepatectomy (PH) – a surgical resection of approximately 2/3 of the murine liver. When liver regeneration following either hepatectomy or necrosis occurred in the absence of Rb, the result was deregulated hepatocyte division, with acceleration of hepatocyte proliferation. Loss of Rb also inhibited the normal process of polyploidisation, whi
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43

Nitta, Ryan Takeo. "A-type lamins are necessary for the stabilization of the retinoblastoma protein /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9209.

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44

Guay, Patrick-Jean. "Studies on the mechanism of function of retinoblastoma binding protein-1 (RBP1)." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33766.

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Proteins from the pRb family have all been demonstrated to actively repress transcription of E2F target genes. Previous studies have shown that they recruit both HDAC-dependent and -independent repression functions. RBP1 has been found to participate in the recruitment of HDAC to pRb through interaction via its R2 domain with the Sin3 HDAC complex. RBP1 also bring HDAC-independent repression to pRb via its R1 domain. However, the repression mechanism of R1 remains elusive. Preliminary studies suggested that HAT activity might be associated with the ARID domain portion of R1. The present study
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45

Andrusiak, Matthew. "Differential Roles for the Retinoblastoma Protein in Cycling and Quiescent Neural Populations." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24037.

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While the genetics of retinoblastoma and the implications of the retinoblastoma susceptibility gene, RB1, are well described, there is still scarce evidence to suggest why RB1 acts in such a cell-type specific manner. Using the murine cortex as a model, we examined the effects of RB1 deletion of cycling neural progenitors and post-mitotic neurons, in order to ascertain cell-type specific functions in the central nervous system. Using the previously identified cell-cycle independent role for Rb in tangential migration, we validated Rb/E2f regulation of neogenin and implicated it in this process
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46

Guy, Michelle. "An investigation into the role of the retinoblastoma protein in colorectal carcinogenesis." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341500.

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47

Solano, Ana Gabriela Reis. "Desenvolvimento de implantes poliméricos intraoculares contendo etoposídeo destinados ao tratamento do retinoblastoma." Universidade Federal de Minas Gerais, 2014. http://hdl.handle.net/1843/EMCO-9RVEF7.

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Retinoblastoma is an intraocular most common childhood malignancy and its treatment by systemic chemotherapy has some devantagens: limited penetration of the drug to the posterior segment of the eyeball and systemic toxicity. The intraocular implants rpresentam a promising alternative for the treatment of retinoblastoma. Moreover, these systems are able to protect labile drugs in physiological conditions, such as etoposide, commonly employed anti-tumor systemic chemotherapy retinoblastoma, slightly soluble in water and unstable in acid and alkaline media. The poly (-caprolactone) (PCL) and pol
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48

Helt, Anna-Marija. "Multiple biological activities of the human papillomavirus type 16 E7 oncoprotein contribute to the abrogation of human epithelial cell cycle control /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/11514.

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49

Korenjak, Michael. "Purification and Characterization of Retinoblastoma like Factor-containing Protein Complexes from Drosophila melanogaster." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-63245.

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50

Barrette-Corbeil, Hugues. "Role of the retinoblastoma tumour suppressor family in transformation, differentiation, and cell cycle." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0022/NQ29887.pdf.

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