Academic literature on the topic 'Retinoid pathway gene expression'

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Journal articles on the topic "Retinoid pathway gene expression"

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Lefebvre, Bruno, Céline Brand, Sébastien Flajollet та Philippe Lefebvre. "Down-Regulation of the Tumor Suppressor Gene Retinoic Acid Receptor β2 through the Phosphoinositide 3-Kinase/Akt Signaling Pathway". Molecular Endocrinology 20, № 9 (2006): 2109–21. http://dx.doi.org/10.1210/me.2005-0321.

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Abstract The retinoic acid receptor β2 (RARβ2) is a potent, retinoid-inducible tumor suppressor gene, which is a critical molecular relay for retinoid actions in cells. Its down-regulation, or loss of expression, leads to resistance of cancer cells to retinoid treatment. Up to now, no primary mechanism underlying the repression of the RARβ2 gene expression, hence affecting cellular retinoid sensitivity, has been identified. Here, we demonstrate that the phosphoinositide 3-kinase/Akt signaling pathway affects cellular retinoid sensitivity, by regulating corepressor recruitment to the RARβ2 prom
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Mehta, Kapil, Teresa McQueen, Taghi Manshouri, Michael Andreeff, Steven Collins та Maher Albitar. "Involvement of Retinoic Acid Receptor-α–Mediated Signaling Pathway in Induction of CD38 Cell-Surface Antigen". Blood 89, № 10 (1997): 3607–14. http://dx.doi.org/10.1182/blood.v89.10.3607.

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Abstract Human leukocyte antigen CD38, a 45-kD single-chain, transmembrane glycoprotein, is a bifunctional ectoenzyme that participates in signal transduction pathways involved in the regulation of cell growth and differentiation. In this study, we demonstrate the nature of retinoid receptors involved in retinoic acid–induced expression of CD38 protein in the human myeloblastic leukemia cell line HL-60. We used a variant HL-60 cell line, HL-60R, in which retinoid receptor function has been abrogated by a trans-dominant negative mutation. We introduced the normal retinoic acid receptors (RAR)-α
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Mehta, Kapil, Teresa McQueen, Taghi Manshouri, Michael Andreeff, Steven Collins та Maher Albitar. "Involvement of Retinoic Acid Receptor-α–Mediated Signaling Pathway in Induction of CD38 Cell-Surface Antigen". Blood 89, № 10 (1997): 3607–14. http://dx.doi.org/10.1182/blood.v89.10.3607.3607_3607_3614.

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Human leukocyte antigen CD38, a 45-kD single-chain, transmembrane glycoprotein, is a bifunctional ectoenzyme that participates in signal transduction pathways involved in the regulation of cell growth and differentiation. In this study, we demonstrate the nature of retinoid receptors involved in retinoic acid–induced expression of CD38 protein in the human myeloblastic leukemia cell line HL-60. We used a variant HL-60 cell line, HL-60R, in which retinoid receptor function has been abrogated by a trans-dominant negative mutation. We introduced the normal retinoic acid receptors (RAR)-α, -β, and
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Murphy, Philip T., Gary Lynch, Stephen Bergin та ін. "Strong Correlation Between CTLA-4 and LEF1 Gene Expression Levels in CLL: Targeting of the Wnt/β-Catenin Pathway May Adversely Affect CTLA-4 Expression and Function". Blood 128, № 22 (2016): 5571. http://dx.doi.org/10.1182/blood.v128.22.5571.5571.

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Abstract Recently published clinical trials have confirmed the effectiveness of anti-CD38 monoclonal antibody therapy in myeloma. Furthermore, in vitro studies of chronic lymphocytic leukaemia (CLL) cells suggest that CD38 expression can be enhanced by treatment with retinoid derivatives and thus may enhance the cytotoxic effects of anti-CD38 therapy. However, retinoids have been shown to have diverse effects on cellular function and we have previously shown that the retinoid drug acitretin upregulates CD38 expression while also reducing cell homing to the chemokine CXCL12 in primary CLL cells
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Aydemir, Gamze, Marta Domínguez, Angel R. de Lera, Johanna Mihaly, Dániel Törőcsik, and Ralph Rühl. "Apo-14´-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid." Nutrients 11, no. 9 (2019): 2084. http://dx.doi.org/10.3390/nu11092084.

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Carotenoids can be metabolized to various apo-carotenoids and retinoids. Apo-15´-carotenoic acid (retinoic acid, RA) is a potent activator of the retinoic acid receptor (RAR) in its all-trans- (ATRA) and 9-cis- (9CRA) forms. In this study we show firstly, that apo-14´-carotenoic acid (A14CA), besides retinoic acids, is present endogenously and with increased levels in the human organism after carrot juice supplementation rich in β-carotene. All-trans-A14C (ATA14CA) is just a moderate activator of RAR-transactivation in reporter cell lines but can potently activate retinoic acid response elemen
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van der Wees, J., J. G. Schilthuis, C. H. Koster, et al. "Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain." Development 125, no. 3 (1998): 545–56. http://dx.doi.org/10.1242/dev.125.3.545.

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Retinoids regulate gene expression via nuclear retinoic acid receptors, the RARs and RXRs. To investigate the functions of retinoid receptors during early neural development, we expressed a dominant negative RARbeta in early Xenopus embryos. We obtained evidence that dominant negative RARbeta specifically inhibits RAR/RXR heterodimer-mediated, but not RXR homodimer-mediated, transactivation. Both all-trans- and 9-cis-RA-induced teratogenesis were, however, efficiently opposed by ectopic expression of dominant negative RARbeta, indicating that only RAR/RXR transactivation is required for retino
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Park, Dorothy J., Peter T. Vuong, Sven de Vos, Dan Douer та H. Phillip Koeffler. "Comparative analysis of genes regulated by PML/RARα and PLZF/RARα in response to retinoic acid using oligonucleotide arrays". Blood 102, № 10 (2003): 3727–36. http://dx.doi.org/10.1182/blood-2003-02-0412.

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Abstract Acute promyelocytic leukemia (APL) is associated with chromosomal translocations involving retinoic acid receptor α (RARα) and its fusion partners including promyelocytic leukemia (PML) and promyelocytic leukemia zinc finger (PLZF). Using oligonucleotide arrays, we examined changes in global gene expression mediated by the ectopic expression of either PML/RARα (retinoid-sensitive) or PLZF/RARα (retinoid-resistant) in U937 cells. Of more than 5000 genes analyzed, 16 genes were commonly up-regulated, and 57 genes were down-regulated by both fusion proteins suggesting their role in the A
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Quere, Ronan, Aurelie Baudet, Bruno Cassinat, et al. "Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity." Blood 109, no. 10 (2007): 4450–60. http://dx.doi.org/10.1182/blood-2006-10-051086.

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AbstractDisease relapse sometimes occurs after acute promyelocytic leukemia (APL) therapy with all-trans retinoic acid (ATRA). Among the diagnostic parameters predicting relapse, heterogeneity in the in vitro differentiation rate of blasts is an independent factor. To identify biologic networks involved in resistance, we conducted pharmacogenomic studies in APL blasts displaying distinct ATRA sensitivities. Although the expression profiles of genes invested in differentiation were similarly modulated in low- and high-sensitive blasts, low-sensitive cells showed higher levels of transcription o
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Lehrke, Ingo, Matthias Schaier, Kerstin Schade, et al. "Retinoid receptor-specific agonists alleviate experimental glomerulonephritis." American Journal of Physiology-Renal Physiology 282, no. 4 (2002): F741—F751. http://dx.doi.org/10.1152/ajprenal.00026.2001.

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Retinoids are potent antiproliferative and anti-inflammatory compounds. We previously demonstrated that the natural pan-agonists all- trans retinoic acid (RA) and 13- cis RA efficiently preserve renal structure and function in rat mesangioproliferative glomerulonephritis. We examine effects of synthetic retinoid receptor-specific agonists 1) to identify common and receptor subtype-specific pathways in this model and 2) to characterize effects of retinoids on the renal endothelin (ET) system. Vehicle-injected control rats were compared with rats treated with daily subcutaneous injections of ago
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Hoffman, Lisa M., Kamal Garcha, Konstantina Karamboulas, et al. "BMP action in skeletogenesis involves attenuation of retinoid signaling." Journal of Cell Biology 174, no. 1 (2006): 101–13. http://dx.doi.org/10.1083/jcb.200604150.

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The bone morphogenetic protein (BMP) and growth and differentiation factor (GDF) signaling pathways have well-established and essential roles within the developing skeleton in coordinating the formation of cartilaginous anlagen. However, the identification of bona fide targets that underlie the action of these signaling molecules in chondrogenesis has remained elusive. We have identified the gene for the retinoic acid (RA) synthesis enzyme Aldh1a2 as a principal target of BMP signaling; prochondrogenic BMPs or GDFs lead to attenuation of Aldh1a2 expression and, consequently, to reduced activat
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Dissertations / Theses on the topic "Retinoid pathway gene expression"

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Sokolova, Natalia Valerievna. "The role of vitamin A in embryonic lung development in mice." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320687.

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Hörnberg, Maria. "Effects of retinoic acid in the mouse olfactory sensory systems /." Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1371.

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Wang, Xiao Elston Timothy C. "Mathematical modeling of signaling pathway dynamics and stochastic gene expression." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,367.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Statistics and Operations Research." Discipline: Statistics and Operations Research; Department/School: Statistics and Operations Research.
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Wright, Alan. "Bayesian pathway analysis in epigenetics." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1286.

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A typical gene expression data set consists of measurements of a large number of gene expressions, on a relatively small number of subjects, classified according to two or more outcomes, for example cancer or non-cancer. The identification of associations between gene expressions and outcome is a huge multiple testing problem. Early approaches to this problem involved the application of thousands of univariate tests with corrections for multiplicity. Over the past decade, numerous studies have demonstrated that analyzing gene expression data structured into predefined gene sets can produce ben
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Georgiades, Pantelis. "Studies of the expression and function of the retinoid-X-receptor y gene in rodent embryonic development." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244677.

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Livingstone, Julie. "Gene expression and bioinformatics analysis of the isoflavonoid pathway in soybean." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66992.

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The phenylpropanoid pathway is highly researched due to t he putative nutraceutical benefits of its secondary metabolites. The enzymes of this pathway are member of gene families, but the exact number of gene homologues has to date been unknown. In this study, expressed sequence tags (ESTs) were used to identify all homologues in the isoflavonoid pathway of soybean (Glycine max L. Merr.). Gene expression of all homologues in whole tissues, and at a cellular level in the pod was also investigated using laser capture microdissection (LCM) and real time reverse-transcription pol
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Stenico, Verena <1983&gt. "Genus Bifidobacterium: taxonomy studies and gene expression analysis on folate pathway." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6604/.

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Folates (vitamin B9) are essential water soluble vitamins, whose deficiency in humans may contribute to the onset of several diseases, such as anaemia, cancer, cardiovascular diseases, neurological problems as well as defects in embryonic development. Human and other mammals are unable to synthesize ex novo folate obtaining it from exogenous sources, via intestinal absorption. Recently the gut microbiota has been identified as an important source of folates and the selection and use of folate producing microorganisms represents an innovative strategy to increase human folate levels. The aim
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Stelios, Pavlidis. "Pathway based microarray analysis based on multi-membership gene regulation." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/6968.

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Recent developments in automation and novel experimental techniques have led to the accumulation of vast amounts of biological data and the emergence of numerous databases to store the wealth of information. Consequentially, bioinformatics have drawn considerable attention, accompanied by the development of a plethora of tools for the analysis of biological data. DNA microarrays constitute a prominent example of a high-throughput experimental technique that has required substantial contribution of bioinformatics tools. Following its popularity there is an on-going effort to integrate gene expr
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Newton, Sherylanne. "Noise-induced hearing loss : changes in gene expression in the auditory pathway." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40895.

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Noise induced hearing loss is classically divided into permanent or temporary forms. Individuals with permanent threshold shifts (PTS) will permanently lose auditory sensitivity, whereas individuals with temporary threshold shifts (TTS) will experience elevated hearing thresholds immediately following noise exposure, which resolves over several weeks. TTS causes little lasting damage to the hair cell, stereocilia or supporting structures which form the organ of Corti within the inner ear, and was therefore considered “no harm, no foul”. However, recent evidence suggests that TTS and PTS also l
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Shen, Ying. "Regulation of EphA4 expression through the APC-mediated ubiquitin-proteasome pathway /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BICH%202007%20SHEN.

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Books on the topic "Retinoid pathway gene expression"

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Valkonen, Mari. Functional studies of the secretory pathway of filamentous fungi: The effect of unfolded protein response on protein production. VTT Technical Research Centre of Finland, 2003.

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Alizadeh-Azami, Solmaz. Is there a common antipsychotic pathway for neuronal gene expression in vitro? 2006.

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Methylation pathway perturbations with folate deficiency: A role for epigenetics in endothelial gene expression. National Library of Canada, 2003.

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Lotfi, Shamim. Molecular mechanisms underlying the expression of proglucagon gene: Role of the Epac signaling pathway in the intestinal endocrine L cells. 2005.

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Merl, Dan, Joseph Lucas, Joseph Nevins, Haige Shen, and Mike West. Trans-study projection of genomic biomarkers in analysis of oncogene deregulation and breast cancer. Edited by Anthony O'Hagan and Mike West. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198703174.013.6.

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This article focuses on the use of Bayesian concepts and methods in the trans-study projection of genomic biomarkers for the analysis of oncogene deregulation in breast cancer. The objective of the study is to determine the extent to which patterns of gene expression associated with experimentally induced oncogene pathway deregulation can be used to investigate oncogene pathway activity in real human cancers. This is often referred to as the in vitro to in vivo translation problem, which is addressed using Bayesian sparse factor regression analysis for model-based translation and refinement of
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Menon, Deepa U. Autism and Intellectual Disabilities. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0053.

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PTEN (phosphatase and tensin homologue) on chromosome 10q23.3 is a tumor suppressor gene that encodes for a dual specificity phosphatase that regulates the phosphatidylinositol 3- kinase pathway and has an important role in brain development by affecting neuronal survival, neurite outgrowth, synaptic plasticity, and learning memory. Germline mutations of the PTEN gene have been implicated in a group of related tumor syndromes with autosomal dominant inheritance and variable expression and include the Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome, and Juvenile Polyposis s
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Kan, Carol, and Ma-Li Wong. Genetics. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.003.0004.

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An association between type 2 diabetes mellitus (T2DM) and depression has been reported in epidemiological studies. Finding a genetic overlap between T2DM and depression will provide evidence to support a common biological pathway to both disorders. Genetic correlations observed from twin studies indicate that a small magnitude of the variance in liability can be attributed to genetic factors. However, no genetic overlap has been observed between T2DM and depression in genome-wide association studies using both the polygenic score and the linkage disequilibrium score regression approaches. Cla
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Book chapters on the topic "Retinoid pathway gene expression"

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Nugent, Paul, and Robert M. Greene. "Use of Antisense Oligonucleotides to Study the Role of CRABPs in Retinoic Acid-Induced Gene Expression." In Retinoid Protocols. Humana Press, 1998. http://dx.doi.org/10.1385/0-89603-438-0:191.

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Brody, Edward, Joëlle Marie, Maria S. Goux-Pelletan, and Béatrice Clouet d’Orval. "Alternative Splicing to Tissue Specific Splicing - An Evolutionary Pathway?" In Evolutionary Tinkering in Gene Expression. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5664-6_19.

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Tsybovsky, Yaroslav, and Krzysztof Palczewski. "Retinoid Pathway Gene Mutations and the Pathophysiology of Related Visual Diseases." In The Retinoids. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118628003.ch24.

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Adametz, David, Mélanie Rey, and Volker Roth. "Information Bottleneck for Pathway-Centric Gene Expression Analysis." In Lecture Notes in Computer Science. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-11752-2_7.

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AlAjlan, Amani, and Ghada Badr. "Data Mining in Pathway Analysis for Gene Expression." In Lecture Notes in Computer Science. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20910-4_6.

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Yu, Xiang Sean, Raymond K. Blanchard, Yexun Wang, and Min You. "Gene Expression Arrays for Pathway Analysis in Cancer Research." In Principles of Molecular Oncology. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-470-4_7.

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Žgombić, Mirna, and Gregg Duester. "DNA Elements Mediating Retinoid and Thyroid Hormone Regulation of Alcohol Dehydrogenase Gene Expression." In Advances in Experimental Medicine and Biology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2904-0_60.

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Zyla, Joanna, Kinga Leszczorz, and Joanna Polanska. "Robustness of Pathway Enrichment Analysis to Transcriptome-Wide Gene Expression Platform." In Advances in Intelligent Systems and Computing. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-54568-0_18.

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Karagiannaki, Ioulia, Yannis Pantazis, Ekaterini Chatzaki, and Ioannis Tsamardinos. "Pathway Activity Score Learning for Dimensionality Reduction of Gene Expression Data." In Discovery Science. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-61527-7_17.

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Abstract Molecular gene-expression datasets consist of samples with tens of thousands of measured quantities (e.g., high dimensional data). However, there exist lower-dimensional representations that retain the useful information. We present a novel algorithm for such dimensionality reduction called Pathway Activity Score Learning (PASL). The major novelty of PASL is that the constructed features directly correspond to known molecular pathways and can be interpreted as pathway activity scores. Hence, unlike PCA and similar methods, PASL’s latent space has a relatively straight-forward biological interpretation. As a use-case, PASL is applied on two collections of breast cancer and leukemia gene expression datasets. We show that PASL does retain the predictive information for disease classification on new, unseen datasets, as well as outperforming PLIER, a recently proposed competitive method. We also show that differential activation pathway analysis provides complementary information to standard gene set enrichment analysis. The code is available at https://github.com/mensxmachina/PASL.
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Wykoff, Charles C., Christopher W. Pugh, Adrian L. Harris, Patrick H. Maxwell, and Peter J. Ratcliffe. "The HIF Pathway: Implications for Patterns of Gene Expression in Cancer." In Novartis Foundation Symposia. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470868716.ch15.

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Conference papers on the topic "Retinoid pathway gene expression"

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Yu, Le, S. Marshall, T. Forster, and P. Ghazal. "Modelling of macrophage gene expression in the interferon pathway." In 2006 IEEE International Workshop on Genomic Signal Processing and Statistics. IEEE, 2006. http://dx.doi.org/10.1109/gensips.2006.353148.

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Yue Zhao, Tham H. Hoang, Pujan Joshi, Seung-Hyun Hong, and Dong-Guk Shin. "Deep pathway analysis incorporating mutation information and gene expression data." In 2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2016. http://dx.doi.org/10.1109/bibm.2016.7822528.

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KURHEKAR, M. P., S. ADAK, S. JHUNJHUNWALA, and K. RAGHUPATHY. "GENOME-WIDE PATHWAY ANALYSIS AND VISUALIZATION USING GENE EXPRESSION DATA." In Proceedings of the Pacific Symposium. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812799623_0043.

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Kim, Hyunsoo, and Markus Bredel. "Predicting survial by cancer pathway gene expression profiles in the TCGA." In 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW). IEEE, 2012. http://dx.doi.org/10.1109/bibmw.2012.6470256.

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Zhang, Mingrui, Beya Adamu, Chi-Cheng Lin, and Ping Yang. "Gene expression analysis with integrated fuzzy C-means and pathway analysis." In 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2011. http://dx.doi.org/10.1109/iembs.2011.6090211.

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Wu, Zhong, John DiCarlo, Yexun Wang та Vikram Devgan. "Abstract A43: Gene expression signature for Wnt/β-catenin signaling pathway." У Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-a43.

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Joshi, Pujan, Honglin Wang, Brent Basso, Seung-Hyun Hong, Charles Giardina, and Dong-Guk Shin. "A Framework for Route Based Pathway Analysis of Gene Expression Data." In ICCBB '20: 2020 4th International Conference on Computational Biology and Bioinformatics. ACM, 2020. http://dx.doi.org/10.1145/3449258.3449262.

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Baarsma, HA, H. Meurs, AJ Halayko, and R. Gosens. "Wnt Pathway Gene Expression in Airway Smooth Muscle and Bronchial Epithelial Cells." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3895.

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Roelofs, Pieter A., William L. Brown, Paul N. Span, et al. "Abstract 286: Regulation of APOBEC3B gene expression through the Rb/E2F pathway." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-286.

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Yang, Sihyung, April E. Cho, Eunhye Lee, Soojeong Lim, Raymond F. Novak, and So Hee Kim. "Abstract 3408: Gene expression profiling of MCF10A series of Ha-Ras transformed human breast epithelial cells: Gene expression involved in EMT pathway." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3408.

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Reports on the topic "Retinoid pathway gene expression"

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Dixon, Richard A. Systematic Modification of Monolignol Pathway Gene Expression for Improved Lignocellulose Utilization. Office of Scientific and Technical Information (OSTI), 2010. http://dx.doi.org/10.2172/985404.

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