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Journal articles on the topic 'Retroelement'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Mustafin, R. N. "Participation of retroelements in chromoanagenesis in cancer development." Siberian journal of oncology 23, no. 5 (2024): 146–56. http://dx.doi.org/10.21294/1814-4861-2024-23-5-146-156.

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Purpose of the study: to determine the role of retroelements in chromoanagenesis mechanisms in cancer etiopathogenesis.Material and Methods. The search for relevant sources was carried out in the Scopus, Web of Science, PubMed, Elibrary systems, including publications from February 2002 to December 2023. Of the 864 scientifc articles found, 60 were used to write a systematic review.Results. According to original works and meta-analyses results, the cause of complex chromosomal rearrangements during cancer development may be retroelement pathological activation. Chromoanagenesis involves LINE1,

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2

Honda, Tomoyuki, Keiko Takemoto, and Keiji Ueda. "Identification of a Retroelement-Containing Human Transcript Induced in the Nucleus by Vaccination." International Journal of Molecular Sciences 20, no. 12 (2019): 2875. http://dx.doi.org/10.3390/ijms20122875.

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Endogenous retroelements constitute almost half of the mammalian genome. Given that more than 60% of human genomic bases are transcribed, transcripts containing these retroelements may impact various biological processes. However, the physiological roles of most retroelement-containing transcripts are yet to be revealed. Here, we profiled the expression of retroelement-containing human transcripts during vaccination and found that vaccination upregulated transcripts containing only particular retroelements, such as the MLT-int element of endogenous retroviruses. MLT-int-containing transcripts

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Springer, Mark S., Erin K. Molloy, Daniel B. Sloan, Mark P. Simmons, and John Gatesy. "ILS-Aware Analysis of Low-Homoplasy Retroelement Insertions: Inference of Species Trees and Introgression Using Quartets." Journal of Heredity 111, no. 2 (2019): 147–68. http://dx.doi.org/10.1093/jhered/esz076.

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Abstract DNA sequence alignments have provided the majority of data for inferring phylogenetic relationships with both concatenation and coalescent methods. However, DNA sequences are susceptible to extensive homoplasy, especially for deep divergences in the Tree of Life. Retroelement insertions have emerged as a powerful alternative to sequences for deciphering evolutionary relationships because these data are nearly homoplasy-free. In addition, retroelement insertions satisfy the “no intralocus-recombination” assumption of summary coalescent methods because they are singular events and bette

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Carotti, Elisa, Edith Tittarelli, Adriana Canapa, Maria Assunta Biscotti, Federica Carducci, and Marco Barucca. "LTR Retroelements and Bird Adaptation to Arid Environments." International Journal of Molecular Sciences 24, no. 7 (2023): 6332. http://dx.doi.org/10.3390/ijms24076332.

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TEs are known to be among the main drivers in genome evolution, leading to the generation of evolutionary advantages that favor the success of organisms. The aim of this work was to investigate the TE landscape in bird genomes to look for a possible relationship between the amount of specific TE types and environmental changes that characterized the Oligocene era in Australia. Therefore, the mobilome of 29 bird species, belonging to a total of 11 orders, was analyzed. Our results confirmed that LINE retroelements are not predominant in all species of this evolutionary lineage and highlighted a

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Murata, Hitoshi, and Akiyoshi Yamada. "marY1, a Member of the gypsyGroup of Long Terminal Repeat Retroelements from the Ectomycorrhizal Basidiomycete Tricholoma matsutake." Applied and Environmental Microbiology 66, no. 8 (2000): 3642–45. http://dx.doi.org/10.1128/aem.66.8.3642-3645.2000.

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ABSTRACT We cloned an intact copy of a long terminal repeat retroelement designated marY1 from the ectomycorrhizal basidiomyceteTricholoma matsutake. The reverse transcriptase domain is found in T. matsutake and Tricholoma magnivelare worldwide. This finding suggests that retroelements associate with ectomycorrhizal basidiomycetes and may be useful as genetic markers for identification, phylogenetic analysis, and mutagenesis of this fungal group.

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6

Chung, Kevin, Ling Xu, Pengxin Chai, Junhui Peng, Swapnil C. Devarkar, and Anna Marie Pyle. "Structures of a mobile intron retroelement poised to attack its structured DNA target." Science 378, no. 6620 (2022): 627–34. http://dx.doi.org/10.1126/science.abq2844.

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Group II introns are ribozymes that catalyze their self-excision and function as retroelements that invade DNA. As retrotransposons, group II introns form ribonucleoprotein (RNP) complexes that roam the genome, integrating by reversal of forward splicing. Here we show that retrotransposition is achieved by a tertiary complex between a structurally elaborate ribozyme, its protein mobility factor, and a structured DNA substrate. We solved cryo–electron microscopy structures of an intact group IIC intron-maturase retroelement that was poised for integration into a DNA stem-loop motif. By visualiz

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7

Ishak, Charles A., and Daniel D. De Carvalho. "Reactivation of Endogenous Retroelements in Cancer Development and Therapy." Annual Review of Cancer Biology 4, no. 1 (2020): 159–76. http://dx.doi.org/10.1146/annurev-cancerbio-030419-033525.

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Domesticated retroelements contribute extensively as regulatory elements within host gene networks. Upon germline integration, retroelement mobilization is restricted through epigenetic silencing, mutational degradation, and innate immune defenses described as the viral mimicry response. Recent discoveries reveal how early events in tumorigenesis reactivate retroelements to facilitate onco-exaptation, replication stress, retrotransposition, mitotic errors, and sterile inflammation, which collectively disrupt genome integrity. The characterization of altered epigenetic homeostasis at retroeleme

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8

Mota, Ines Frutuoso, Jaspreet Osean, Eric Song, et al. "Characterization of the HLA-F ligandome in T-cell lymphoma." Journal of Immunology 210, no. 1_Supplement (2023): 222.06. http://dx.doi.org/10.4049/jimmunol.210.supp.222.06.

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Abstract Identifying tumor-specific antigens across different types of malignancies and HLA haplotypes remains challenging. Recently, the expression of tumor-specific Human Endogenous Retroelements emerged as a potential new class of cytotoxic T-cell response mediators (1). HLA-F, a non-classic HLA-I molecule, has been hypothesized to present peptides to T-cells and to regulate immunity through interactions with distinct NK-cell receptors (2). HLA-F low genetic diversity and limited peptide repertoire represent an unexplored avenue in cancer immunotherapy. HLA-F-bound peptides were eluted from

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9

Lee, Gloria, Nicholas A. Sherer, Neil H. Kim, et al. "Testing the retroelement invasion hypothesis for the emergence of the ancestral eukaryotic cell." Proceedings of the National Academy of Sciences 115, no. 49 (2018): 12465–70. http://dx.doi.org/10.1073/pnas.1807709115.

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Phylogenetic evidence suggests that the invasion and proliferation of retroelements, selfish mobile genetic elements that copy and paste themselves within a host genome, was one of the early evolutionary events in the emergence of eukaryotes. Here we test the effects of this event by determining the pressures retroelements exert on simple genomes. We transferred two retroelements, human LINE-1 and the bacterial group II intron Ll.LtrB, into bacteria, and find that both are functional and detrimental to growth. We find, surprisingly, that retroelement lethality and proliferation are enhanced by

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10

Furini, Antonella. "CDT retroelement." Plant Signaling & Behavior 3, no. 12 (2008): 1129–31. http://dx.doi.org/10.4161/psb.3.12.7076.

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11

Leblanc, Pascal, Bernard Dastugue, and Chantal Vaury. "The Integration Machinery of ZAM, a Retroelement from Drosophila melanogaster, Acts as a Sequence-Specific Endonuclease." Journal of Virology 73, no. 8 (1999): 7061–64. http://dx.doi.org/10.1128/jvi.73.8.7061-7064.1999.

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ABSTRACT Retroviruses and retrotransposons insert into the host genome with no obvious sequence specificity. We examined the target sites of the retroelement ZAM by sequencing each host-ZAM junction in the genome ofDrosophila melanogaster. Our overall data provide compelling evidence that ZAM integration machinery recognizes and leads to ZAM insertion into the sequence 5′-GCGCGCg-3′. This unique property of ZAM will facilitate the development of new tools to study the integration process of retroelements.

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12

Fukuda, Kei, and Yoichi Shinkai. "SETDB1-Mediated Silencing of Retroelements." Viruses 12, no. 6 (2020): 596. http://dx.doi.org/10.3390/v12060596.

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SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine methyltransferase and methylates histone H3 at lysine 9 (H3K9). Among other H3K9 methyltransferases, SETDB1 and SETDB1-mediated H3K9 trimethylation (H3K9me3) play pivotal roles for silencing of endogenous and exogenous retroelements, thus contributing to genome stability against retroelement transposition. Furthermore, SETDB1 is highly upregulated in various tumor cells. In this article, we describe recent advances about how SETDB1 activity is regulated, how SETDB1 represses various types of retroelements suc

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13

Mustafin, R. N. "The probable role of retroelements in the development of Wilms’ tumor in chromosomal syndromes." Cancer Urology 18, no. 4 (2023): 99–107. http://dx.doi.org/10.17650/1726-9776-2022-18-4-99-107.

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The review article analyzes the data accumulated in the literature on the association of Wilms’ tumor with chromosomal syndromes and searches for possible causes of this phenomenon. In 10 % of all cases, nephroblastoma is represented by a hereditary tumor syndrome due to germline mutations in suppressor genes, mainly in the WT1 gene, less often in WT2, WTX, CTNNB1, TP53. These genes are associated with retroelements that play a role in the development of Wilms’ tumor, promoting carcinogenesis, causing genome instability. LINE-1 retroelement is a negative regulator of WT1 expression, while supp

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14

Buchatskyi, L. P. "Endogenous retroelemens of fish and molluscs." Visnik ukrains'kogo tovaristva genetikiv i selekcioneriv 18, no. 1-2 (2021): 34–43. http://dx.doi.org/10.7124/visnyk.utgis.18.1-2.1353.

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Aim. Analysis of scientific literature sources devoted to the study of retroelements of fish and mollusks. Results. It is shown that endogenous retroelements are widespread both among fish and mollusks. Endogenous retroviruses of fish, like exogenous ones, are also widespread, but their total number in the genomes of fish is much less than in other vertebrates. The Steamer retroelement, the presence of which is associated with the development of tumors in molluscs, can be transmitted horizontally between these invertebrates. In addition, it is able to pass into organisms of other types of aqua

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15

Dosay-Akbulut, Mine. "Intron and Its Splicing Mechanism and Their Connection with Human Disease." Bangladesh Journal of Medical Science 15, no. 3 (2016): 307–12. http://dx.doi.org/10.3329/bjms.v15i3.24527.

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In the maturation mechanism of a messenger RNA, splicing play an important role with removing the noncoding introns and ligating the coding exons. Alternative splicing (AS) gives an extra difficulty to this mechanism and to the regulation of gene expression. The possible disturbing in the alternative RNA splicing mechanism can be a reason to several diseases like cancers and neurodegenerative disorders. Intronless genes (IGs) are seen in almost 3% of the human genome. Functionality of IGs has an important role in signal transduction genes and related regulatory proteins. This diversity can be

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16

Chiu, Ya-Lin, and Warner C. Greene. "APOBEC3G: an intracellular centurion." Philosophical Transactions of the Royal Society B: Biological Sciences 364, no. 1517 (2008): 689–703. http://dx.doi.org/10.1098/rstb.2008.0193.

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The intrinsic antiretroviral factor APOBEC3G (A3G) is highly active against HIV-1 and other retroviruses. In different cell types, A3G is expressed in high-molecular-mass (HMM) RNA–protein complexes or low-molecular-mass (LMM) forms displaying different biological activities. In resting CD4 T cells, a LMM form of A3G potently restricts HIV-1 infection soon after virion entry. However, when T cells are activated, LMM A3G is recruited into HMM complexes that include Staufen-containing RNA granules. These complexes are probably nucleated by the induced expression of Alu/hY retroelement RNAs that

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17

Löber, Ulrike, Matthew Hobbs, Anisha Dayaram, et al. "Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion." Proceedings of the National Academy of Sciences 115, no. 34 (2018): 8609–14. http://dx.doi.org/10.1073/pnas.1807598115.

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Endogenous retroviruses (ERVs) are proviral sequences that result from colonization of the host germ line by exogenous retroviruses. The majority of ERVs represent defective retroviral copies. However, for most ERVs, endogenization occurred millions of years ago, obscuring the stages by which ERVs become defective and the changes in both virus and host important to the process. The koala retrovirus, KoRV, only recently began invading the germ line of the koala (Phascolarctos cinereus), permitting analysis of retroviral endogenization on a prospective basis. Here, we report that recombination w

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18

Nikitin, Daniil, Andrew Garazha, Maxim Sorokin, et al. "Correction: Nikitin, D., et al. Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution. Cells 2019, 8, 130." Cells 8, no. 8 (2019): 832. http://dx.doi.org/10.3390/cells8080832.

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In the article ‘Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution,’ a number of transcription factor binding sites (TFBS) mapped on all retroelement classes were incorrectly calculated as sum of TFBS numbers separately mapped on LINEs, SINEs and LTR retrotransposons/endogenous retroviruses (LR/ERVs) [...]

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19

Levin, H. L. "A novel mechanism of self-primed reverse transcription defines a new family of retroelements." Molecular and Cellular Biology 15, no. 6 (1995): 3310–17. http://dx.doi.org/10.1128/mcb.15.6.3310.

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Retroviruses and long terminal repeat (LTR)-containing retrotransposons initiate reverse transcription by using a specific tRNA primer than anneals to the primer-binding site of the retroelement transcript. Sequences from a large number of retroviruses and LTR-containing retrotransposons had indicated that the role of tRNAs in priming reverse transcription is universal among these LTR-containing retroelements. Data presented here strongly support the surprising conclusion that Tf1, a highly active LTR-containing retrotransposon isolated from Schizosaccharomyces pombe, undergoes a novel self-pr

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20

Lim, Ai Khim, Liheng Tao, and Toshie Kai. "piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline." Journal of Cell Biology 186, no. 3 (2009): 333–42. http://dx.doi.org/10.1083/jcb.200904063.

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Nuage, a well-conserved perinuclear organelle found in germline cells, is thought to mediate retroelement repression in Drosophila melanogaster by regulating the production of Piwi-interacting RNAs (piRNAs). In this study, we present evidence that the nuage–piRNA pathway components can be found in cytoplasmic foci that also contain retroelement transcripts, antisense piRNAs, and proteins involved in messenger RNA (mRNA) degradation. These mRNA degradation proteins, decapping protein 1/2 (DCP1/2), Me31B (maternal expression at 31B), and pacman (PCM), are normally thought of as components of pro

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21

Mroczek, Rebecca J., and R. Kelly Dawe. "Distribution of Retroelements in Centromeres and Neocentromeres of Maize." Genetics 165, no. 2 (2003): 809–19. http://dx.doi.org/10.1093/genetics/165.2.809.

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AbstractFluorescent in situ hybridization was used to examine the distribution of six abundant long terminal repeat (LTR) retroelements, Opie, Huck, Cinful-1, Prem-2/Ji, Grande, and Tekay/Prem-1 on maize pachytene chromosomes. Retroelement staining in euchromatin was remarkably uniform, even when we included the structurally polymorphic abnormal chromosome 10 (Ab10) in our analysis. This uniformity made it possible to use euchromatin as a control for quantitative staining intensity measurements in other regions of the genome. The data show that knobs, known to function as facultative neocentro

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22

Shimamoto, Tadashi, Mihoko Kobayashi, Tomofusa Tsuchiya, et al. "A retroelement in Vibrio cholerae." Molecular Microbiology 34, no. 3 (1999): 631–32. http://dx.doi.org/10.1046/j.1365-2958.1999.01531.x.

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23

Kingsman, Alan J., and Susan M. Kingsman. "Ty: A retroelement moving forward." Cell 53, no. 3 (1988): 333–35. http://dx.doi.org/10.1016/0092-8674(88)90151-1.

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24

Lamb, Jonathan C., and James A. Birchler. "Retroelement Genome Painting: Cytological Visualization of Retroelement Expansions in the Genera Zea and Tripsacum." Genetics 173, no. 2 (2006): 1007–21. http://dx.doi.org/10.1534/genetics.105.053165.

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25

Mustafin, R. N. "Future of epigenetic immunotherapy in kidney cancer." Cancer Urology 19, no. 4 (2024): 158–66. http://dx.doi.org/10.17650/1726-9776-2023-19-4-158-166.

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In clinical practice, immune checkpoint inhibition based on the use of antibodies against PD-1 (programmed death 1), PD-L1 (programmed death-ligand 1) and CTLA-4 (cytotoxic T-lymphocyte-associated antigen 4) is actively used for treatment of kidney cancer. However, objective response to monotherapy with these drugs is observed only in 9–24 % of patients, and combinations with other anticancer drugs in most cases cause severe adverse reactions. At the same time, there is an increased risk of toxic liver damage, immune-dependent pneumonitis, and rash. Therefore, it is necessary to search for new

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26

Cheng, Zhi-Jun, and Minoru Murata. "A Centromeric Tandem Repeat Family Originating From a Part of Ty3/gypsy-Retroelement in Wheat and Its Relatives." Genetics 164, no. 2 (2003): 665–72. http://dx.doi.org/10.1093/genetics/164.2.665.

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AbstractFrom a wild diploid species that is a relative of wheat, Aegilops speltoides, a 301-bp repeat containing 16 copies of a CAA microsatellite was isolated. Southern blot and fluorescence in situ hybridization revealed that ∼250 bp of the sequence is tandemly arrayed at the centromere regions of A- and B-genome chromosomes of common wheat and rye chromosomes. Although the DNA sequence of this 250-bp repeat showed no notable homology in the databases, the flanking or intervening sequences between the repeats showed high homologies (&gt;82%) to two separate sequences of the gag gene and

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27

Jiang, Di. "Hitching a ride with a retroelement." Science 373, no. 6557 (2021): 866.3–866. http://dx.doi.org/10.1126/science.373.6557.866-c.

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28

Perlman, P. S. "MOLECULAR BIOLOGY: Ring Around the Retroelement." Science 303, no. 5655 (2004): 182–84. http://dx.doi.org/10.1126/science.1093514.

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29

Simon, Anna J., Barrett R. Morrow, and Andrew D. Ellington. "Retroelement-Based Genome Editing and Evolution." ACS Synthetic Biology 7, no. 11 (2018): 2600–2611. http://dx.doi.org/10.1021/acssynbio.8b00273.

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30

Lee, Ja-Rang, and Heui-Soo Kim. "Radiation-induced retroelement-mediated genomic instability." Biotechnology and Bioprocess Engineering 17, no. 3 (2012): 439–45. http://dx.doi.org/10.1007/s12257-012-0008-3.

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31

Becker, Kristina, Marlen Braune, Natalya Benderska, et al. "A Retroelement Modifies Pre-mRNA Splicing." Journal of Biological Chemistry 287, no. 37 (2012): 31185–94. http://dx.doi.org/10.1074/jbc.m112.375691.

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32

Mahmood, Anarkali, and Erik J. Sontheimer. "PRINTing Transgenes with an Avian Retroelement." GEN Biotechnology 3, no. 2 (2024): 73–74. http://dx.doi.org/10.1089/genbio.2024.29142.ama.

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33

Cloutier, Alison, Timothy B. Sackton, Phil Grayson, Michele Clamp, Allan J. Baker, and Scott V. Edwards. "Whole-Genome Analyses Resolve the Phylogeny of Flightless Birds (Palaeognathae) in the Presence of an Empirical Anomaly Zone." Systematic Biology 68, no. 6 (2019): 937–55. http://dx.doi.org/10.1093/sysbio/syz019.

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Abstract Palaeognathae represent one of the two basal lineages in modern birds, and comprise the volant (flighted) tinamous and the flightless ratites. Resolving palaeognath phylogenetic relationships has historically proved difficult, and short internal branches separating major palaeognath lineages in previous molecular phylogenies suggest that extensive incomplete lineage sorting (ILS) might have accompanied a rapid ancient divergence. Here, we investigate palaeognath relationships using genome-wide data sets of three types of noncoding nuclear markers, together totaling 20,850 loci and ove

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34

dos Santos Costa, Maria, Hallana Cristina Menezes da Silva, Simone Cardoso Soares, et al. "A Perspective of Molecular Cytogenomics, Toxicology, and Epigenetics for the Increase of Heterochromatic Regions and Retrotransposable Elements in Tambaqui (Colossoma macropomum) Exposed to the Parasiticide Trichlorfon." Animals 12, no. 15 (2022): 1945. http://dx.doi.org/10.3390/ani12151945.

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Rex retroelements are the best-known transposable elements class and are broadly distributed through fish and also individual genomes, playing an important role in their evolutionary dynamics. Several agents can stress these elements; among them, there are some parasitic compounds such as the organochlorophosphate Trichlorfon. Consequently, knowing that the organochlorophosphate Trichlorfon is indiscriminately used as an antiparasitic in aquaculture, the current study aimed to analyze the effects of this compound on the activation of the Transposable Elements (TEs) Rex1, Rex3, and Rex6 and the

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Staplin, William R., and Joseph A. Knezetic. "BVL-1–like VL30 promoter sustains long-term expression in erythroid progenitor cells." Blood 101, no. 5 (2003): 1798–800. http://dx.doi.org/10.1182/blood-2002-07-2105.

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Congenital blood disorders are common and yet clinically challenging globin disorders. Gene therapy continues to serve as a potential therapeutic method to treat these disorders. While tremendous advances have been made in vivo, gene delivery protocols and vector prototypes still require optimization. Alternativecis-acting promoter elements derived from VL30 retroelements have been effective in expressing tissue-specific transgene expression in vivo in nonerythroid cells. VL30 promoter elements were isolated from ELM-I-1 erythroid progenitor cells upon erythropoietin (epo) treatment. These pro

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Cohen, Carla J., Rita Rebollo, Sonja Babovic, Elizabeth L. Dai, Wendy P. Robinson та Dixie L. Mager. "Placenta-specific Expression of the Interleukin-2 (IL-2) Receptor β Subunit from an Endogenous Retroviral Promoter". Journal of Biological Chemistry 286, № 41 (2011): 35543–52. http://dx.doi.org/10.1074/jbc.m111.227637.

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The long terminal repeat (LTR) sequences of endogenous retroviruses and retroelements contain promoter elements and are known to form chimeric transcripts with nearby cellular genes. Here we show that an LTR of the THE1D retroelement family has been domesticated as an alternative promoter of human IL2RB, the gene encoding the β subunit of the IL-2 receptor. The LTR promoter confers expression specifically in the placental trophoblast as opposed to its native transcription in the hematopoietic system. Rather than sequence-specific determinants, DNA methylation was found to regulate transcriptio

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Ustyugova, Svetlana V., Anna L. Amosova, Yuri B. Lebedev, and Eugene D. Sverdlov. "Cell line fingerprinting using retroelement insertion polymorphism." BioTechniques 38, no. 4 (2005): 561–65. http://dx.doi.org/10.2144/05384st02.

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Brennan, Michael T., and Jean-Luc C. Mougeot. "Alu retroelement-associated autoimmunity in Sjögren's syndrome." Oral Diseases 22, no. 5 (2016): 345–47. http://dx.doi.org/10.1111/odi.12462.

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39

P�lissier, T., S. Tutois, J. M. Deragon, S. Tourmente, S. Genestier, and G. Picard. "Athila, a new retroelement from Arabidopsis thaliana." Plant Molecular Biology 29, no. 3 (1995): 441–52. http://dx.doi.org/10.1007/bf00020976.

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Das, Rasel, Tadashi Shimamoto, and Md Arifuzzaman. "A Novel msDNA (Multicopy Single-Stranded DNA) Strain Present inYersinia frederikseniiATCC 33641 Contig01029 Enteropathogenic Bacteria with the Genomic Analysis of It's Retron." Journal of Pathogens 2011 (2011): 1–6. http://dx.doi.org/10.4061/2011/693769.

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Retron is a retroelement that encodes msDNA (multicopy single-stranded DNA) which was significantly found mainly in Gram-negative pathogenic bacteria. We screenedYersinia frederikseniiATCC 33641 contig01029 for the presence of retroelement by using bioinformatics tools and characterized a novel retron-Yf79 on the chromosome that encodes msDNA-Yf79. In this study, we perceived that, the codon usage of retron-Yf79 were noteworthy different from those of theY. frederikseniigenome. It demonstrates that, the retron-Yf79 was a foreign DNA element and integrated into this organism genome during their

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Carducci, Federica, Maria Assunta Biscotti, Mariko Forconi, Marco Barucca, and Adriana Canapa. "An intriguing relationship between teleost Rex3 retroelement and environmental temperature." Biology Letters 15, no. 9 (2019): 20190279. http://dx.doi.org/10.1098/rsbl.2019.0279.

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The movement and accumulation of transposable elements (TEs) exert a great influence on the host genome, e.g. determining architecture and genome size, providing a substrate for homologous recombination and DNA rearrangements. TEs are also known to be responsive and susceptible to environmental changes. However, the correlation between environmental conditions and the sequence evolution of TEs is still an unexplored field of research. Among vertebrates, teleosts represent a successful group of animals adapted to a wide range of different environments and their genome is constituted by a rich r

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Xia, Miaoran, Bingbing Wang, Wujianan Sun, et al. "Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses." Life Science Alliance 6, no. 10 (2023): e202302042. http://dx.doi.org/10.26508/lsa.202302042.

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The histone demethylase Lsd1 has been shown to play multiple essential roles in mammalian biology. However, its physiological functions in thymocyte development remain elusive. We observed that the specific deletion of Lsd1 in thymocytes caused significant thymic atrophy and reduced peripheral T cell populations with impaired proliferation capacity. Single-cell RNA sequencing combined with strand-specific total RNA-seq and ChIP-seq analysis revealed that ablation of Lsd1 led to the aberrant derepression of endogenous retroelements, which resulted in a viral mimicry state and activated the inte

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Kobayashi, Hiroko, Mitsuki Yasukochi, Masayuki Horie, et al. "Neuron-associated retroelement-derived protein Arc/Arg3.1 assists in the early stages of alphaherpesvirus infection in human neuronal cells." PLOS ONE 19, no. 12 (2024): e0314980. https://doi.org/10.1371/journal.pone.0314980.

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Alphaherpesviruses, including herpes simplex virus type 1 (HSV-1) and pseudorabies virus (PRV), are neurotropic double-stranded DNA viruses. Alphaherpesviruses control the expression of various host factors to ensure efficient infection and propagation. Recently, HSV-1 was found to upregulate Arc/Arg3.1 (Arc) expression, which is a retroelement-derived domesticated gene. Arc is associated with learning and neuroplasticity in host neuronal cells, and its abnormal expression leads to neurological disorders. However, the detailed mechanisms underlying the upregulation of Arc and its physiological

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44

Papamichos, Spyros I. "Endogenous Retroelement-Driven Expression of OCT4B mRNA Variants." Stem Cell Reviews and Reports 17, no. 3 (2021): 1078–80. http://dx.doi.org/10.1007/s12015-021-10146-6.

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Jiang, Rays H. Y., and Francine Govers. "Nonneutral GC3 and Retroelement Codon Mimicry in Phytophthora." Journal of Molecular Evolution 63, no. 4 (2006): 458–72. http://dx.doi.org/10.1007/s00239-005-0211-3.

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Kingsman, A. "Retroelement particles as purification, presentation and targeting vehicles." Trends in Biotechnology 9, no. 1 (1991): 303–9. http://dx.doi.org/10.1016/0167-7799(91)90100-v.

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Platt II, Roy N., and David A. Ray. "A non-LTR retroelement extinction in Spermophilus tridecemlineatus." Gene 500, no. 1 (2012): 47–53. http://dx.doi.org/10.1016/j.gene.2012.03.051.

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Castro-Diaz, Nathaly, Marc Friedli, and Didier Trono. "Drawing a fine line on endogenous retroelement activity." Mobile Genetic Elements 5, no. 1 (2015): 1–6. http://dx.doi.org/10.1080/2159256x.2015.1006109.

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Guo, Huatao, Longping V. Tse, Angela W. Nieh, et al. "Target Site Recognition by a Diversity-Generating Retroelement." PLoS Genetics 7, no. 12 (2011): e1002414. http://dx.doi.org/10.1371/journal.pgen.1002414.

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GAO, X., and D. VOYTAS. "A eukaryotic gene family related to retroelement integrases." Trends in Genetics 21, no. 3 (2005): 133–37. http://dx.doi.org/10.1016/j.tig.2005.01.006.

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