Academic literature on the topic 'Retronecina'

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Journal articles on the topic "Retronecina"

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El-Shazly, Assem, M. Abdel-All, Andreas Tei, and Michael Wink. "Pyrrolizidine Alkaloids from Echium rauwolfii and Echium horridum (Boraginaceae)." Zeitschrift für Naturforschung C 54, no. 5-6 (1999): 295–300. http://dx.doi.org/10.1515/znc-1999-5-601.

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Abstract Echimidine was isolated from Echium rauwolfii and Echium horridum and identified by MS, 1H-and 13C NMR as a major alkaloid. In addition, structures of 12 minor alkaloids were inferred from GLC and GLC-MS analyses: 7-angeloylretronecine, 7-tigloylretronecine, lycopsamine, 7-acetyllycopsamine, uplandicine, 7-angeloyllycopsamine, 7-tigloyllycopsamine, tigloyl isomer of echimidine, 7-angeloyl-9-(2-methylbutyryl)retronecine, 7-tigloyl-9-(2-methylbutyryl)retronecine, 7-angeloyl-9-(2,3-dihydroxybutyryl)retronecine, and 7-tigloyl-9-(2,3-dihydroxybutyryl)retronecine. Both species had similar a
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Clare, BW, V. Ferro, BW Skelton, RV Stick, and AH White. "Approaches to the Synthesis of Retronecine From Some Pyrrolidine Precursors." Australian Journal of Chemistry 46, no. 6 (1993): 805. http://dx.doi.org/10.1071/ch9930805.

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Procedures are described for the attempted conversion of the pyrrolidine (2) into a bicyclic system that would ultimately lead to retronecine (3). The only molecule to be isolated from these attempts was the epimeric ketone (6), and AM1 and MM2 calculations were used to probe this apparently favoured isomerization. Alternative procedures were then investigated that sought to convert the pyrrolidine (1) into precursors to retronecine, and notable successes were obtained with the addition of the amine (21) to both nitroethene and ethyl 2-diethylphosphonoacrylate. However, not only were these pre
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Ehmke, Adelheid, Ludger Witte, Andreas Biller, and Thomas Hartmann. "Sequestration, N-Oxidation and Transformation of Plant Pyrrolizidine Alkaloids by the Arctiid Moth Tyria jacobaeae L." Zeitschrift für Naturforschung C 45, no. 11-12 (1990): 1185–92. http://dx.doi.org/10.1515/znc-1990-11-1217.

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Larvae of the arctiid moth Tyria jacobaeae reared on Senecio jacobaea or S. vulgaris take up and store pyrrolizidine alkaloids (PAs) from their host plants. Individual PAs are taken up without preference. The PA patterns found in the insect bodies correspond to the PA composi­tion of their host plants. Like plants the insects store PAs as N-oxides, and larvae as well as pupae are specifically able to N -oxidize any tertiary PA. Callimorphine (O9-(2-methyl-2-acetoxybutanoyl)-retronecine), an insect PA well known from several arctiids, was found in pupae and imagines of Tyria which as larvae had
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Yan, J., Q. Xia, MW Chou, and PP Fu. "Metabolic activation of retronecine and retronecine N-oxide – formation of DHP-derived DNA adducts." Toxicology and Industrial Health 24, no. 3 (2008): 181–88. http://dx.doi.org/10.1177/0748233708093727.

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Zheng, Pimiao, Yuliang Xu, Zhenhui Ren, et al. "Toxic Prediction of Pyrrolizidine Alkaloids and Structure-Dependent Induction of Apoptosis in HepaRG Cells." Oxidative Medicine and Cellular Longevity 2021 (January 2, 2021): 1–12. http://dx.doi.org/10.1155/2021/8822304.

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Pyrrolizidine alkaloids (PAs) are common phytotoxins and could cause liver genotoxicity/carcinogenicity following metabolic activation. However, the toxicity of different structures remains unclear due to the wide variety of PAs. In this study, the absorption, distribution, metabolism, excretion, and toxicity (ADMET) of 40 PAs were analyzed, and their toxicity was predicted by Komputer Assisted Technology (TOPKAT) using Discovery Studio software. The in silico results showed that all PAs except retronecine had good intestinal absorption, and all PAs were predicted to have different toxicity ra
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Culvenor, CCJ, and MF Mackay. "The Absolute Structure of Latifoline." Australian Journal of Chemistry 45, no. 2 (1992): 451. http://dx.doi.org/10.1071/ch9920451.

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The absolute structure of latifoline, a pyrrolizidine diester alkaloid of retronecine and latifolic and angelic acids, has been defined by single-crystal X-ray crystallographic analysis of the hydrobromide salt hydrate. Orthorhombic crystals of C20H27NO7.HBr.H2O belong to the space group P 2′2′2′ with a 7.279(1), b 17.898(3), c 17.922(2) � and V 2334-9(8) � 3 . The structure has been refined to an R index of 0.054 for 1725 observed terms. The absolute configuration has been assigned by comparison with that of retronecine and also determined independently by X-ray examination of selected Bijvoe
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Morrie Craig, A., Jeannette T. Hovermale, Fraser F. Fleming, and James D. White. "Improved Labelling Methods for C9-2H-Retronecine." HETEROCYCLES 38, no. 1 (1994): 135. http://dx.doi.org/10.3987/com-93-6543.

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Glinski, J. A., D. VanDerveer, and L. H. Zalkow. "Diastereoisomeric epoxides of heliotridine and retronecine, C8H13NO3." Acta Crystallographica Section C Crystal Structure Communications 41, no. 9 (1985): 1345–48. http://dx.doi.org/10.1107/s0108270185007715.

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Ferro, V., BW Skelton, RV Stick, and AH White. "The Synthesis of Some Pyrrolidines as Potential Precursors to Retronecine." Australian Journal of Chemistry 46, no. 6 (1993): 787. http://dx.doi.org/10.1071/ch9930787.

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Methyl β-D-galactopyranoside was converted into methyl 4-azido-3-O-benzyl-6-O-t-butyldiphenylsilyl-2,4-dideoxy-β-D-arabino-hexoside, but subsequent transformation of the anomeric centre into a dithioacetal was unsatisfactory. Alternatively, methyl β-D- galactopyranoside easily gave methyl 4-azido-3,6-di-O-benzyl-2,4-dideoxy-β-D-arabino-hexoside, and this could be transformed by a reductive amination into two pyrrolidines as potential precursors to retronecine. Related chemistry gave (4S,5S,6R)-6-benzyloxy-4-benzyloxymethyl-3-oxa-1-azabicyclo[3.3.0]octan-2-one, the structure of which was confir
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Gelbaum, L. T., J. A. Glinski, D. VanDerveer, and L. H. Zalkow. "Retronecine and heliotridine, C8H13NO2: diastereoisomeric pyrrolizidine necine bases." Acta Crystallographica Section C Crystal Structure Communications 41, no. 9 (1985): 1342–45. http://dx.doi.org/10.1107/s0108270185007703.

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Dissertations / Theses on the topic "Retronecina"

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Conegero, Leila de Souza. "Estudos visando a sintese de alcaloides pirrolizidinicos e indolizidinicos : aproveitamento da (+)-retronecina e do acido D-isoascorbico." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249280.

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Orientador: Ronaldo Aloise Pilli<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-08T05:17:50Z (GMT). No. of bitstreams: 1 Conegero_LeiladeSouza_D.pdf: 3438551 bytes, checksum: 26a173748a7748d7ec479a812badeeb7 (MD5) Previous issue date: 2006<br>Resumo: O trabalho desenvolvido visou a obtenção de alcalóides pirrolizidínicos e indolizidínicos utilizando a (+)-retronecina (1) e o ácido D-isoascórbico (35D) como matérias primas, respectivamente. A retronecina (1) foi isolada da espécie vegetal Senecio brasiliensis. Para a prepar
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Smith, Joshua C. "Studies towards the total synthesis of (+)-retronecine and anthracimycin." Thesis, University of York, 2016. http://etheses.whiterose.ac.uk/16427/.

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This thesis consists of two separate projects. The first project involved an attempted total synthesis of (+)-retronecine A, a poisonous pyrrolizidine alkaloid via a novel asymmetric α-lithiation-substitution reaction of N-thiopivaloyl azetidine B, mediated by a chiral diamine. A total synthesis was not possible and our attention turned towards elucidating the mechanism of enantioinduction. Of particular note was how the use of carbon dioxide and methyl chloroformate as electrophiles gave products with the opposite configuration under otherwise identical reaction conditions (using (–)-spartein
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Zirngibl, Katharina [Verfasser], Reinhard [Akademischer Betreuer] Nießner, Dietmar [Gutachter] Knopp, and Reinhard [Gutachter] Nießner. "Generierung und Charakterisierung eines monoklonalen Antikörpers für die Detektion von Retronecin-basierten Pyrrolizidinalkaloiden und seine Verwendung für die Entwicklung eines Immunoassays / Katharina Zirngibl ; Gutachter: Dietmar Knopp, Reinhard Nießner ; Betreuer: Reinhard Nießner." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/122503910X/34.

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Huang, Jie-Ming, and 黃界閔. "The Application of Free Radical Cyclizations in the Synthesis of Heliotridine, Retronecine and Other Analogous Pyrrolizidine Alkaloids." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/95375293570658711876.

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博士<br>國立臺灣大學<br>化學研究所<br>90<br>英 文 摘 要 Using the radical cyclization strategy developed previously in our laboratory for the synthesis of the alkaloid (-)-supinidine, we now synthesized two pyrrolidine alkaloids (+)-heliotridine and (-)-retronecine. Both alkaloids contained two stereogenic centers. According to similar methodology, we are also able to synthesize 7a-epi-uspallatinecine which is an analog of the natural pyrrolizidine alkaloid uspallatinecine. Starting from readily available enantio-pure starting material L-(-)-malic acid, we prepared a chiral imide 70 tha
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