Academic literature on the topic 'RETROVIRAL PROTEASE'

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Dissertations / Theses on the topic "RETROVIRAL PROTEASE"

1

Peng, Kah Whye. "Protease-activatable targeted retroviral vectors." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624668.

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2

Garner, Joanne Clare. "Site directed mutagenesis, autoprocessing and inhibitor studies on the retroviral protease of the human immunodeficiency virus type-1." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302318.

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3

Muller, Natalie Guida. "Identificação de epitopos da protease de HIV-1 alvos de respostas de células T CD4+ em pacientes infectados pelo HIV-1." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-05032010-170301/.

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Introdução: Uma proporção significante de pacientes infectados por HIV-1 (pacientes HIV-1+) tratados com inibidores de protease (IPs) desenvolve mutações de resistência. Estudos recentes têm mostrado que células T CD8+ de pacientes HIV- 1+ reconhecem epitopos de Pol incluindo mutações selecionadas por drogas. Nenhum epitopo CD4+ da protease foi descrito na base de dados de Los Alamos. Objetivo: Considerando que a protease de HIV-1 é alvo de terapia antiretroviral e que essa pressão pode selecionar mutações, nós investigamos se mutações selecionadas por IPs afetariam o reconhecimento de epitopo
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4

Junaid, Muhammad. "Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets : Applications in Antiviral Drug Discovery & Therapy." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173504.

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Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. The flaviviruses, such as Dengue virus (DEN) and Japanese encephalitis virus (JEV), represent other major cause of morbidity and mortality, and the areas where these viruses are endemic are spreading rapidly. No curative therapy for any flavivirus could be made av
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5

Hinks, John Andrew. "Studies of retroviral proteases." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445580/.

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This work is primarily concerned with the expression, purification, and characterisation of aspartic proteases from three retroviruses of the lentivirus subgroup, specifically the Human Immunodeficiency Viruses types 1 and 2, and the Simian Immunodeficiency Virus isolated from the African Green Monkey (HIV-1 PR, HIV-2 PR, SIVagm PR respectively). These viruses cause immunodeficiency syndromes within their respective hosts, and understanding their molecular biology would facilitate development of Acquired Immunodeficiency Syndrome (AIDS) treatments in man. The proteases are essential to viral m
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6

Leblanc, Pascal. "Retrovirus d'invertebres : zam un nouveau candidat chez drosophila melanogaster." Clermont-Ferrand 1, 1998. http://www.theses.fr/1998CLF1MM12.

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7

GESSNER, JEAN-YVES. "La proteine de la nucleocapside du retrovirus vih-1." Strasbourg 1, 1992. http://www.theses.fr/1992STR15031.

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8

Schucht, Roland. "Entwicklung von flexiblen Zelllinien für die Produktion rekombinanter Proteine und Retroviren." kostenfrei, 2006. http://www.digibib.tu-bs.de/?docid=00014003.

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9

Morphet, Marilynn Norma. "Method for identification of effective first-line treatment for HAART naïve HIV/AIDS patients." Thesis, Queensland University of Technology, 2002.

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10

Ménard, Armelle. "Purification, activité et inhibition de la protéase du rétrovirus BLV : un modèle d'étude pour celle du HTLV-1." Bordeaux 2, 1994. http://www.theses.fr/1993BOR28278.

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