Relevant bibliographies by topics / Retrovirinae

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Retrovirinae'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Retrovirinae"

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Kaplan, Mark H. "Reviews and Notes: Virology: The Retroviridae." Annals of Internal Medicine 125, no. 9 (November 1, 1996): 783. http://dx.doi.org/10.7326/0003-4819-125-9-199611010-00034.

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FRANCHINI, GENOVEFFA, and MARVIN S. REITZ. "Phylogenesis and Genetic Complexity of the Nonhuman Primate Retroviridae." AIDS Research and Human Retroviruses 10, no. 9 (September 1994): 1047–60. http://dx.doi.org/10.1089/aid.1994.10.1047.

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Posada, David, and Keith A. Crandall. "Simple (Wrong) Models for Complex Trees: A Case from Retroviridae." Molecular Biology and Evolution 18, no. 2 (February 1, 2001): 271–75. http://dx.doi.org/10.1093/oxfordjournals.molbev.a003802.

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Martin, Joanne, Peter Kabat, Elisabeth Herniou, and Michael Tristem. "Characterization and Complete Nucleotide Sequence of an Unusual Reptilian Retrovirus Recovered from the Order Crocodylia." Journal of Virology 76, no. 9 (May 1, 2002): 4651–54. http://dx.doi.org/10.1128/jvi.76.9.4651-4654.2002.

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ABSTRACT A novel group of retroviruses found within the order Crocodylia are described. Phylogenetic analyses demonstrate that they are probably the most divergent members of the Retroviridae described to date; even the most conserved regions of Pol show an average of only 23% amino acid identity when compared to other retroviruses.
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Hotta, J., and P. C. Loh. "Enhanced Production of a Human Spumavirus (Retroviridae) in Semi-permissive Cell Cultures after Treatment with 5-Azacytidine." Journal of General Virology 68, no. 4 (April 1, 1987): 1183–86. http://dx.doi.org/10.1099/0022-1317-68-4-1183.

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Llorens, Carlos, Mario A. Fares, and Andres Moya. "Relationships of Gag-pol Diversity between Ty3/Gypsy and Retroviridae LTR retroelements and the three kings hypothesis." BMC Evolutionary Biology 8, no. 1 (2008): 276. http://dx.doi.org/10.1186/1471-2148-8-276.

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Karn, Jonathan. "The retroviridae (Vol. 1)Jay A. Levy Plenum Press, 1992, $95.00 hbk (xiv + 483 pages) ISBN 0 306 44074 1." Trends in Genetics 9, no. 7 (July 1993): 257. http://dx.doi.org/10.1016/0168-9525(93)90096-z.

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Obr, Martin, Florian K. M. Schur, and Robert A. Dick. "A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly." Viruses 13, no. 9 (September 17, 2021): 1853. http://dx.doi.org/10.3390/v13091853.

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The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles. However, the molecular details underlying this effect have been determined only recently, with the identification of the IP6 binding site in the immature Gag lattice. IP6 also promotes formation of the mature capsid protein (CA) lattice via a second IP6 binding site, and enhances core stability, creating a favorable environment for reverse transcription. IP6 also enhances assembly of other retroviruses, from both the Lentivirus and the Alpharetrovirus genera. These findings suggest that IP6 may have a conserved function throughout the family Retroviridae. Here, we discuss the different steps in the viral life cycle that are influenced by IP6, and describe in detail how IP6 interacts with the immature and mature lattices of different retroviruses.
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Requejo, Henry I. Z. "Worldwide molecular epidemiology of HIV." Revista de Saúde Pública 40, no. 2 (April 2006): 331–45. http://dx.doi.org/10.1590/s0034-89102006000200023.

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Human immunodeficiency virus (HIV) is the worldwide disseminated causative agent of acquired immunodeficiency syndrome (AIDS). HIV is a member of the Lentivirus genus of Retroviridae family and is grouped in two types named HIV-1 and HIV-2. These viruses have a notable ability to mutate and adapt to the new conditions of human environment. A large incidence of errors at the transcriptional level results in changes on the genetic bases during the reproductive cycle. The elevated genomic variability of HIV has carried important implications for the diagnosis, treatment and prevention as well as epidemiologic investigations. The present review describes important definitions and geographical distribution of subtypes, circulating recombinant forms and other genomic variations of HIV. The present study aimed at leading students of Biomedical Sciences and public health laboratory staff guidance to general and specific knowledge about the genomic variability of the HIV.
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Goudsmit, Jaap. "The Retroviridae (Vol. 1)edited by Jay A. levy Plenum Press, 1992. $114.00 hbk (504 pages) ISBN 0 306 44074 1." Trends in Microbiology 2, no. 4 (April 1994): 144–45. http://dx.doi.org/10.1016/0966-842x(94)90604-1.

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Dissertations / Theses on the topic "Retrovirinae"

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Lüftenegger, Daniel. "Einfluss posttranslationaler Modifikationen auf die Funktion des Prototyp Foamy Virus Hüllproteins." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1207905094649-72075.

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Die Familie der Retrovirinae wird in zwei Unterfamilien untergliedert, die Orthoretrovirinae und die Spumaretrovirinae. Foamyviren stellen aufgrund einiger besonderer Eigenschaften die einzigen Vertreter dieser Unterfamilie, die sie als Bindeglied zwischen den Retroviren und den Hepadnaviren erscheinen lassen. So erfolgt beispielsweise die reverse Transkription des viralen Genoms nicht erst nach Eintritt in die Zielzelle, sondern, anders als bei Orthoretroviren, bereits in der Produzentenzelle noch während oder kurz nach der Morphogenese. Diese Eigenschaft teilen Foamyviren mit den Hepadnaviren ebenso wie die obligate Koexpression der Kapsidproteine mit den viralen Hüllproteinen für die Freisetzung von Viruspartikeln. Im Gegensatz zu Orthoretroviren sind Foamyviren folglich nicht in der Lage virusähnliche Partikel (VLP) zu sekretieren und die spezifische Funktion des PFV Env Proteins kann nicht durch heterologe Hüllproteine übernommen werden. Die Synthese des PFV Env Vorläuferproteins erfolgt am rER, wobei es eine Typ III Membrantopologie erhält, mit sowohl dem N- als auch dem C-Terminus im Zytoplasma. Während des Transports des Proteins zum Ort der Partikelknospung, wird es posttranslational im Golgi-Apparat, oder dem trans-Golgi Netzwerk, durch Furin oder eine Furin-ähnliche Protease in drei partikelassoziierte Untereinheiten prozessiert. Eine Partikelassoziation retroviraler Signalpeptide ist bislang nur für Foamyviren nachgewiesen worden, genauso wie eine essentielle Rolle dieses Proteins bei der Interaktion zwischen dem
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Lüftenegger, Daniel. "Einfluss posttranslationaler Modifikationen auf die Funktion des Prototyp Foamy Virus Hüllproteins." Doctoral thesis, Technische Universität Dresden, 2007. https://tud.qucosa.de/id/qucosa%3A23754.

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Die Familie der Retrovirinae wird in zwei Unterfamilien untergliedert, die Orthoretrovirinae und die Spumaretrovirinae. Foamyviren stellen aufgrund einiger besonderer Eigenschaften die einzigen Vertreter dieser Unterfamilie, die sie als Bindeglied zwischen den Retroviren und den Hepadnaviren erscheinen lassen. So erfolgt beispielsweise die reverse Transkription des viralen Genoms nicht erst nach Eintritt in die Zielzelle, sondern, anders als bei Orthoretroviren, bereits in der Produzentenzelle noch während oder kurz nach der Morphogenese. Diese Eigenschaft teilen Foamyviren mit den Hepadnaviren ebenso wie die obligate Koexpression der Kapsidproteine mit den viralen Hüllproteinen für die Freisetzung von Viruspartikeln. Im Gegensatz zu Orthoretroviren sind Foamyviren folglich nicht in der Lage virusähnliche Partikel (VLP) zu sekretieren und die spezifische Funktion des PFV Env Proteins kann nicht durch heterologe Hüllproteine übernommen werden. Die Synthese des PFV Env Vorläuferproteins erfolgt am rER, wobei es eine Typ III Membrantopologie erhält, mit sowohl dem N- als auch dem C-Terminus im Zytoplasma. Während des Transports des Proteins zum Ort der Partikelknospung, wird es posttranslational im Golgi-Apparat, oder dem trans-Golgi Netzwerk, durch Furin oder eine Furin-ähnliche Protease in drei partikelassoziierte Untereinheiten prozessiert. Eine Partikelassoziation retroviraler Signalpeptide ist bislang nur für Foamyviren nachgewiesen worden, genauso wie eine essentielle Rolle dieses Proteins bei der Interaktion zwischen dem
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Sowinski, Stefanie. "Transmission and immune surveillance of human T cell-tropic retroviridae." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501764.

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Dirks, Clarissa A. "The role of cellular factors in retrovirus replication /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5072.

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Sayah, David. "Retrovirus restriction in primates and the discovery of TRIMCyp /." Saarbrücken : VDM Verlag Dr. Müller, 2008. http://d-nb.info/989322068/04.

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Bolinger, Cheryl Giles. "Study of translation control by a RNA helicase A-responsive post-transcriptional control element in Retroviridae." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1226513076.

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Olival, Guilherme Sciascia do. "Caracterização clínica e imagiológica de pacientes com esclerose múltipla e associação com retrovírus endógeno da família W." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-22012019-140839/.

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Introdução: A esclerose múltipla (EM) é uma doença inflamatória autoimune desmielinizante. Diversos estudos evidenciaram a forte associação entre a EM e a expressão do retrovírus endógeno da família W (HERV-W) e do Epstein Barr Vírus (EBV), sem definir seu real papel no desenvolvimento da doença. Objetivo: Investigar a presença de anticorpos anti EBV e a expressão de HERV-W em pacientes com EM e avaliar a correlação entre a atividade clínica e imagiológica da EM com a avaliação quantitativa do HERV-W e EBV. Métodos: Realizamos avaliações clínicas e de ressonância magnética (RM) por 36 meses de 36 pacientes com EM e a comparamos com a análise quantitativa longitudinal do PCR em tempo real do RNA do HERV-W em PBMC e uma análise transversal por ELISA do anti VCA IgG e IgM de EBV. Foram utilizados dois grupos controles sendo o primeiro com 30 indíviduos saudáveis e o segundo com 26 pacientes com outras doenças neurológicas (ODN) para comparação com os títulos de HERV-W e anti- EBV. Resultados: A dosagem do IgG EBV foi estatisticamente maior no grupo EM quando comparado ao grupo controle saudável (p = 0,024) e a expressão de HERV-W foi estatisticamente maior tanto no grupo EM (p = 0,001) como no grupo ODN (p = 0,022) quando comparados com os controles saudáveis nos grupos de pacientes. Nenhuma sorologia IgM do EBV foi positiva. A avaliação longitudinal da expressão relativa do HERV-W não apresentou correlação com nenhum dos parâmetros clínicos ou imagiológicos de avaliação da EM sendo eles: tipo de EM; medicamento em uso; EDSS; taxa anualizada de surtos; novas lesões em T2/FLAIR pela RM; lesões captando gadolíneo pela RM. Conclusão: Existe uma expressão relativa de HERV-W aumentada em pacientes com EM e em ODN quando comparados com controles saudáveis. Os pacientes com EM apresentam valores superiores de anticorpos IgG anti- EBV. Não encontramos nenhuma correlação na avaliação longitudinal entre a atividade clínica e imagiológica de pacientes com EM e a avaliação quantitativa do HERV-W e do anticorpo anti-EBV.
Introduction: Multiple sclerosis (MS) is a demyelinating autoimmune inflammatory disease. Several studies have demonstrated the strong association between MS and the expression of endogenous retrovirus W (HERV-W) and Epstein Barr Virus (EBV), without defining its true role in the development of the disease. Objective: To investigate the presence of anti-EBV antibodies and HERV-W expression in MS patients and to evaluate the correlation between the clinical and imaging activity of MS with the quantitative evaluation of HERV-W and EBV. Method: We performed clinical and magnetic resonance imaging (MRI) evaluations for 36 months of 36 MS patients and compared it with the longitudinal quantitative real-time PCR analysis of HERV-W RNA in PBMC and a cross-sectional analysis by anti-VCA IgG and EBV IgM ELISA. Two control groups were used, the first with 30 healthy subjects and the second with 26 patients with other neurological diseases (OND) for comparison with HERV-W and anti-EBV titers. Results: IgG EBV was statistically higher in the MS group when compared to the healthy control group (p = 0.024). HERV-W expression was statistically higher in the MS group (p = 0.001) and the OND group (p = 0.022) when compared to healthy controls. No IgM EBV serology was positive. The longitudinal evaluation of the relative expression of HERV-W did not present any correlation with the clinical or MRI of the MS group following parameters: type of MS; medication in use; EDSS; annualized rate of relapses; new MRI T2/FLAIR lesions; MRI gadolinium enhancing lesions. Conclusion: There is a relative increased HERV-W expression in patients with MS and in OND when compared with healthy controls. Patients with MS have higher values of anti-EBV IgG antibodies. We found no correlation in the longitudinal evaluation between the clinical and imaging.
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Romano, Camila Malta. "Caracterização e dinâmica evolutiva de retrovírus endógenos da família K (ERV-K) em genomas de primatas." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-29012010-105745/.

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Retrovírus endógenos (ERVs) são vírus que infectaram células germinativas e proliferaram no genoma do hospedeiro. A família K está integrada apenas no genoma de primatas do Velho Mundo. Os ERVs promovem alterações estruturais nos genomas hospedeiros, sendo fundamentais para a sua evolução. Esse trabalho teve como objetivo realizar uma investigação da distribuição e dinâmica evolutiva de ERV-K nos diferentes hospedeiros. Foram identificados 58 ERV-K em humanos, 38 em chimpanzés, 35 em orangotangos e 19 em macaco rhesus. Análises filogenéticas evidenciaram dois grupos principais, Grupo O/N, que compreende os provirus mais antigos e os mais recentes, e Grupo I, com provirus com tempo de integração intermediário. A dinâmica de espalhamento de ERV-K diferiu entre os hospedeiros. A fixação e eliminação dos ERV-K é resultado de fatores demográficos e populacionais, como gargalos de garrafa e expansões sofridas ao longo da evolução. Análises de quais provírus são ativos em pacientes com HIV e com cancer demonstrou que distintos ERVs são transativados, sugerindo alguma consequencia biológica para o hospedeiro. Além disso, a atividade dos ERVs não depende exclusivamente do tempo de integração, mas sim da integridade de regiões específicas contidas na LTR.
Endogenous retroviruses (ERVs) are remains of ancient viral infection in the germ line cells and subsequent vertical transmission. The K family are integrated only in humans and the Old World monkeys. ERVs play a fundamental role on genome evolution and foster variability. The aim of this work was to investigate their distribution and evolutionary dynamics in primate hosts. We found 55 ERV-K genomes in the human genome, 38 in chimpanzee, 35 in orangutan and 19 in Rhesus monkey. Two main groups were recovered by phylogenetic inference, Group O/N, comprising the newest and the oldest proviruses and, Group I, enclosing those with intermediate integration time. Although the primary integration took place in the ancestral lineage of all primates investigated, their evolutionary dynamic was different among them. I propose that ERV-K dynamics depends on the host demography experienced throughout their evolution. This work also investigated the putative source of proviral transcripts detected in HIV carries and cancer patients. The differential expression found under these conditions suggested a biological role of the ERV-K overexpression. Finally, the results showed that the ERV-K overexpression depends on the integrity of specific promoters in their LTR.
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Murray, Shannon. "Foamy virus-host interactions /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/4987.

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Caleiro, Giovana Santos. "Investigação da presença do retrovírus da Reticuloendoteliose aviária (REV) e do anticorpo IgG do vírus Oeste do Nilo (WNV) em aves." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-04092018-090320/.

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As aves podem carregar um grande número de patógenos. As aves migratórias, por viajarem longas distâncias, são as principais responsáveis pela disseminação de agentes infecciosos. Entre os agentes, destacam-se os vírus, como por exemplo o retrovírus da Reticuloendoteliose aviária (REV), amplamente distribuído; e o vírus da febre do Oeste do Nilo (WNV), uma virose reemergente, com caráter zoonótico. Os principais sintomas da Reticuloendoteliose aviária incluem anemia, doença de Runting e síndrome não neoplásica aguda. Já o agente etiológico da Febre do Nilo Ocidental, é o Flavivirus West Nile (WNV).. As aves são seus hospedeiros definitivos e os humanos são hospedeiros acidentais, podendo manifestar quadro febril, e em menor porcentagem, meningite e encefalite. Mosquitos dos gêneros Culex e Aedes spp são os principais transmissores do vírus. Ao contrário do REV que não dispõe de evidências de sua circulação no Brasil, há evidências do WNV em aves e equinos e mais recentemente, em humanos. O objetivo desse trabalho foi investigar a presença do REV e do WNV em aves silvestres e de cativeiro da cidade de São Paulo e do Norte do estado do Pará. Sangue, soro e swab de cloaca foram coletados, totalizando mais de 1000 amostras. Através de técnicas moleculares foi possível detectar a presença do REV em 74 amostras (16%), todas do estado do Pará. O sequenciamento parcial dessas amostras e sua filogenia sugeriu que a migração de aves EUA-Brasil possa ter sido a rota utilizada. Através de ELISA anti-IgG de WNV, 4 amostras de São Paulo foram positivas. Apresentamos a primeira evidência do REV no país e sugerimos a presença do WNV no estado de São Paulo.
Birds can carry a large number of pathogens. The migratory birds are most responsible for the spread of infectious agents due to long distance travels. Among these pathogens, the most notable are viruses, such as the avian Reticuloendotheliosis retrovirus (REV), widely distributed; and the West Nile virus (WNV), a reemerging zoonotic disease. The main symptoms of avian reticuloendotheliosis include anemia, Runting\'s disease and acute nonneoplastic syndrome. The etiological agent of West Nile fever is Flavivirus West Nile (WNV). Birds are their definitive hosts and humans are accidental hosts, which generaly present febrile symptoms, but at less proportion,, meningitis and encephalitis. Mosquitoes of the genus Culex and Aedes spp are the main vectors of the virus. Differently from the REV that has no evidence of its circulation in Brazil, there is evidence of WNV in birds and horses and more recently in humans. The objective of this work was to investigate the presence of REV and WNV in wild birds and captive birds from the city of São Paulo and Northern from Pará State. Blood, serum and cloacal swab were collected, resulting in more than 1000 samples. Through molecular techniques it was possible to detect the presence of REV in 74 samples (16%), all from the State of Pará. The partial sequencing of these samples and their phylogeny suggested that the migration of US-Brazil may have been the route for the virus entry. Through anti-WNV IgG ELISA, 4 samples from São Paulo were positive. We present the first evidence of REV in the country and suggest the presence of WNV in the state of São Paulo.
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Books on the topic "Retrovirinae"

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Levy, Jay A., ed. The Retroviridae. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3372-6.

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Levy, Jay A., ed. The Retroviridae. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1627-3.

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Levy, Jay A., ed. The Retroviridae. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1721-8.

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Levy, Jay A., ed. The Retroviridae. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4899-1730-0.

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Retroviruses: Molecular biology, genomics and pathogenesis. Norfolk, UK: Caister Academic, 2010.

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Organization, World Health, ed. 21st Congress of the IABS on progress in animal retroviruses: Proceedings of a symposium. Basel: Karger, 1990.

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Desrosiers, R. C., and Anna M. Skalka. Abstracts of papers presented at the 1996 meeting on retroviruses, May 21-May 26, 1996. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory, 1996.

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Johnson-Delaney, Cathy A. Simian and human retroviruses in nonhuman primates: Infection, disease and animal model studies : a bibliography, 1992-1993 annual update. Seattle, Wash: Primate Information Center, Regional Primate Research Center, University of Washington, 1994.

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Johnson-Delaney, Cathy A. Simian and human retroviruses in nonhuman primates: Infection, disease and animal model studies : a bibliography, 1990-1991 annual update. Seattle: Primate Information Center, Regional Primate Research Center, University of Washington, 1991.

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Johnson-Delaney, Cathy A. Simian & human retroviruses in nonhuman primates: Infection, disease & animal model studies : a bibliography, 1988-1989 annual update. Seattle, Wash: Primate Information Center, Regional Primate Research Center, University of Washington, 1989.

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Book chapters on the topic "Retrovirinae"

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Ou, S. H. Ignatius, and Richard B. Gaynor. "Intracellular Factors Involved in Gene Expression of Human Retroviruses." In The Retroviridae, 97–184. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1721-8_2.

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Weiss, Robin A. "Cellular Receptors and Viral Glycoproteins Involved in Retrovirus Entry." In The Retroviridae, 1–108. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1627-3_1.

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Narayan, Opendra, Mary C. Zink, Mark Gorrell, Sharon Crane, David Huso, Pauline Jolly, Mary Saltarelli, Robert J. Adams, and Janice E. Clements. "The Lentiviruses of Sheep and Goats." In The Retroviridae, 229–55. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1627-3_4.

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Loh, Philip C. "Spumaviruses." In The Retroviridae, 361–97. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1627-3_6.

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Sugamura, Kazuo, and Yorio Hinuma. "Human Retroviruses: HTLV-I and HTLV-II." In The Retroviridae, 399–435. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1627-3_7.

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Barker, Edward, Susan W. Barnett, Leonidas Stamatatos, and Jay A. Levy. "The Human Immunodeficiency Viruses." In The Retroviridae, 1–96. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1721-8_1.

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Peterlin, B. Matija. "Molecular Biology of HIV." In The Retroviridae, 185–238. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1721-8_3.

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Löchelt, Martin, and Rolf M. Flügel. "The Molecular Biology of Human and Primate Spuma Retroviruses." In The Retroviridae, 239–92. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1721-8_4.

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Rasheed, Suraiya. "Retroviruses and Oncogenes." In The Retroviridae, 293–408. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1721-8_5.

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González-Scarano, Francisco, Neal Nathanson, and Paul K. Y. Wong. "Retroviruses and the Nervous System." In The Retroviridae, 409–90. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1721-8_6.

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Conference papers on the topic "Retrovirinae"

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Machado, Francisco Eberson Da Silva, Francisco Eberson Da Silva Machado, Luiz Carlos Teles Nunes, Milena Xavier Silva Barbosa, Ana Letícia Moreira Silva, and Ana Ruth Sampaio Grangeiro. "CONTROLADORES DE ELITE E HIV: UMA REVISÃO DE LITERATURA." In I Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/998.

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Abstract:
Introdução: A Síndrome da imunodeficiência Adquirida (AIDS) é uma consequência crônica da infecção por o Vírus da Imunodeficiência Humana (HIV) pertencente à familia Retroviridae. É estruturalmente constituído por capsídeo icosaédrico, envelopado por fosfolipidios, onde localizam-se as proteínas virais. A AIDS é consequência do não tratamento do paciente com HIV, ocorrendo a diminuição dos linfócitos TCD4, pois o vírus realiza o processo de adsorção em células apresentadoras de antígeno ocorrendo todo o processo da replicação viral intra celular. Alguns indivíduos, apesar de serem portadores do HIV, não apresentam essa diminuição de linfócitos e são chamados de controladores de elite. Objetivo: Fornecer informações sobre os controladores de elite e uma possível cura do HIV com base em estudos recentes. Materiais e Métodos: Tratou-se de uma revisão de literatura, que buscou evidenciar e discutir sobre o mecanismo imunológico dos controladores de elite. Utilizou-se publicações científicas, em idioma português, pesquisados no Google Acadêmico e Scielo entre 2005 a 2019, com os descritores: Controladores de elite e HIV. Desenvolvimento: Os controladores de elite apresentam as concentrações de linfócito TCD4 normais, porém associado a alguma outra patologia como, por exemplo, a tuberculose pulmonar pode levar a ocorrer uma queda lenta desses linfócitos ocasionado uma evolução para AIDS, além disso, os controladores de elite apresentam uma proteção natural que permite que o vírus fique indetectável ou com carga viral abaixo de 50 copias de RNA viral/mL, mesmo sem terapia com antirretrovirais. O diagnóstico confirmatório para os controladores de elite baseia-se no Elisa de 3ª geração e Western Blot. Conclusão: Através dessa pesquisa foi possível observar que pacientes controladores de elite vão possuir interferências no diagnóstico do HIV, tornando necessária a utilização de outras metodologias para fechar o diagnóstico.
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