Relevant bibliographies by topics / Reverse diabetes naturally

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Academic literature on the topic 'Reverse diabetes naturally'

Author: Grafiati
Published: 14 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Reverse diabetes naturally"

1

Scibilia, Renza. "The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally." Clinical Diabetes 37, no. 3 (July 2019): 302–3. http://dx.doi.org/10.2337/cd19-0025.

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2

Hassainya, Y., F. Garcia-Pons, R. Kratzer, V. Lindo, F. Greer, F. A. Lemonnier, G. Niedermann, and P. M. van Endert. "Identification of Naturally Processed HLA-A2--Restricted Proinsulin Epitopes by Reverse Immunology." Diabetes 54, no. 7 (June 27, 2005): 2053–59. http://dx.doi.org/10.2337/diabetes.54.7.2053.

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3

Bansal, Amita, and Rebecca A. Simmons. "Epigenetics and developmental origins of diabetes: correlation or causation?" American Journal of Physiology-Endocrinology and Metabolism 315, no. 1 (July 1, 2018): E15—E28. http://dx.doi.org/10.1152/ajpendo.00424.2017.

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The incidence of metabolic disorders like type 2 diabetes (T2D) and obesity continue to increase. Although it is evident that the increasing incidence of diabetes confers a global societal and economic burden, the mechanisms responsible for the increased incidence of T2D are not well understood. Extensive efforts to understand the association of early-life perturbations with later onset of metabolic diseases, the founding principle of developmental origins of health and disease, have been crucial in determining the mechanisms that may be driving the pathogenesis of T2D. As the programming of the epigenome occurs during critical periods of development, it has emerged as a potential molecular mechanism that could occur early in life and impact metabolic health decades later. In this review, we critically evaluate human and animal studies that illustrated an association of epigenetic processes with development of T2D as well as intervention strategies that have been employed to reverse the perturbed epigenetic modification or reprogram the naturally occurring epigenetic marks to favor improved metabolic outcome. We highlight that although our understanding of epigenetics and its contribution toward developmental origins of T2D continues to grow, whether epigenetics is a cause, consequence, or merely a correlation remains debatable due to the many limitations/challenges of the existing epigenetic studies. Finally, we discuss the potential of establishing collaborative research efforts between different disciplines, including physiology, epigenetics, and bioinformatics, to help advance the developmental origins field with great potential for understanding the pathogenesis of T2D and developing preventive strategies for T2D.
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4

Randeria, Pratik S., Mark A. Seeger, Xiao-Qi Wang, Heather Wilson, Desmond Shipp, Chad A. Mirkin, and Amy S. Paller. "siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown." Proceedings of the National Academy of Sciences 112, no. 18 (April 20, 2015): 5573–78. http://dx.doi.org/10.1073/pnas.1505951112.

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Spherical nucleic acid (SNA) gold nanoparticle conjugates (13-nm-diameter gold cores functionalized with densely packed and highly oriented nucleic acids) dispersed in Aquaphor have been shown to penetrate the epidermal barrier of both intact mouse and human skin, enter keratinocytes, and efficiently down-regulate gene targets. ganglioside-monosialic acid 3 synthase (GM3S) is a known target that is overexpressed in diabetic mice and responsible for causing insulin resistance and impeding wound healing. GM3S SNAs increase keratinocyte migration and proliferation as well as insulin and insulin-like growth factor-1 (IGF1) receptor activation under both normo- and hyperglycemic conditions. The topical application of GM3S SNAs (50 nM) to splinted 6-mm-diameter full-thickness wounds in diet-induced obese diabetic mice decreases local GM3S expression by >80% at the wound edge through an siRNA pathway and fully heals wounds clinically and histologically within 12 d, whereas control-treated wounds are only 50% closed. Granulation tissue area, vascularity, and IGF1 and EGF receptor phosphorylation are increased in GM3S SNA-treated wounds. These data capitalize on the unique ability of SNAs to naturally penetrate the skin and enter keratinocytes without the need for transfection agents. Moreover, the data further validate GM3 as a mediator of the delayed wound healing in type 2 diabetes and support regional GM3 depletion as a promising therapeutic direction.
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5

Wang, L.-J., M. Brännström, K.-H. Cui, A. P. Simula, R. P. Hart, S. Maddocks, and R. J. Norman. "Localisation of mRNA for interleukin-1 receptor and interleukin-1 receptor antagonist in the rat ovary." Journal of Endocrinology 152, no. 1 (January 1997): 11–17. http://dx.doi.org/10.1677/joe.0.1520011.

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Abstract Interleukin-1 (IL-1) is a multifunctional cytokine with profound effects on ovarian function. The effects of IL-1 on ovarian steroidogenesis have been demonstrated in several species. IL-1 mRNA levels are increased in the thecal layer of the ovulating follicle and IL-1β has been shown to induce ovulations in vitro. In this study we have investigated the presence and distribution of the mRNAs for type I IL-1 receptor (IL-1RtI) and for the naturally occurring IL-1 receptor antagonist (IL-1ra) in ovaries of adult cycling rats, to elucidate the target cells for IL-1 action. We have demonstrated the presence of mRNA for both substances by in situ hybridisation and reverse transcription PCR. mRNA for IL-1RtI was not found in primordial follicles but was abundant in the granulosa and thecal layer in developing follicles with stronger signals in the granulosa layer. In the preovulatory and ovulatory follicles, there was a further increase in the signal for IL-1RtI mRNA in the thecal layer compared with the granulosa layer. Corpora lutea were weakly positive at all stages and atretic follicles were largely negative. No mRNA was detected in oocytes of any stage. mRNA for IL-1ra showed a similar distribution to that of IL-1RtI. The changes in distribution suggest an action of IL-1 on rat granulosa cells during follicular development and on thecal cells during ovulation. Journal of Endocrinology (1997) 152, 11–17
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6

Bolger, Graeme B., Mariana F. Bizzi, Sergio V. Pinheiro, Giampaolo Trivellin, Lisa Smoot, Mary-Ann Accavitti, Márta Korbonits, and Antonio Ribeiro-Oliveira. "cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors." Endocrine-Related Cancer 23, no. 5 (May 2016): 419–31. http://dx.doi.org/10.1530/erc-15-0205.

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PDE4 cyclic nucleotide phosphodiesterases regulate cAMP abundance in cells and therefore regulate numerous processes, including cell growth and differentiation. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein (also called XAP2 or ARA-9). Germline mutations inAIPoccur in approximately 20% of patients with Familial Isolated Pituitary Adenoma (FIPA) and 20% of childhood-onset simplex somatotroph adenomas. We therefore examined the protein expression of PDE4A4 and the closely related isoform PDE4A8 in normal human pituitary tissue and in pituitary adenomas. PDE4A4 had low expression in normal pituitary but was significantly overexpressed in somatotroph, lactotroph, corticotroph and clinically nonfunctioning gonadotroph adenomas (P<0.0001 for all subtypes). Likewise, PDE4A8 was expressed in normal pituitary and was also significantly overexpressed in the adenoma subtypes (P<0.0001 for all). Among the different adenoma subtypes, corticotroph and lactotroph adenomas were the highest and lowest expressed for PDE4A4, respectively, whereas the opposite was observed for PDE4A8. Naturally occurring oncogenic variants in AIP were shown by a two-hybrid assay to disrupt the ability of AIP to interact with PDE4A5. A reverse two-hybrid screen identified numerous additional variants in the tetratricopeptide repeat (TPR) region of AIP that also disrupted its ability to interact with PDE4A5. The expression of PDE4A4 and PDE4A8 in normal pituitary, their increased expression in adenomatous pituitary cells where AIP is meant to participate, and the disruption of the PDE4A4–AIP interaction byAIPmutants may play a role in pituitary tumorigenesis.
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7

Jang, Eungyeong, and Jang-Hoon Lee. "Promising Anticancer Activities of Alismatis rhizome and Its Triterpenes via p38 and PI3K/Akt/mTOR Signaling Pathways." Nutrients 13, no. 7 (July 18, 2021): 2455. http://dx.doi.org/10.3390/nu13072455.

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The flowering plant genus Alisma, which belongs to the family Alismataceae, comprises 11 species, including Alisma orientale, Alisma canaliculatum, and Alisma plantago-aquatica. Alismatis rhizome (Ze xie in Chinese, Takusha in Japanese, and Taeksa in Korean, AR), the tubers of medicinal plants from Alisma species, have long been used to treat inflammatory diseases, hyperlipidemia, diabetes, bacterial infection, edema, oliguria, diarrhea, and dizziness. Recent evidence has demonstrated that its extract showed pharmacological activities to effectively reverse cancer-related molecular targets. In particular, triterpenes naturally isolated from AR have been found to exhibit antitumor activity. This study aimed to describe the biological activities and plausible signaling cascades of AR and its main compounds in experimental models representing cancer-related physiology and pathology. Available in vitro and in vivo studies revealed that AR extract possesses anticancer activity against various cancer cells, and the efficacy might be attributed to the cytotoxic and antimetastatic effects of its alisol compounds, such as alisol A, alisol B, and alisol B 23-acetate. Several beneficial functions of triterpenoids found in AR might be due to p38 activation and inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways. Moreover, AR and its triterpenes inhibit the proliferation of cancer cells that are resistant to chemotherapy. Thus, AR and its triterpenes may play potential roles in tumor attack, as well as a therapeutic remedy alone and in combination with other chemotherapeutic drugs.
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8

Maev, Igor V., Aleksey A. Samsonov, Liudmila K. Palgova, Chavdar S. Pavlov, Elena I. Vovk, Elena N. Shirokova, and Kirill M. Starostin. "Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study)." BMJ Open Gastroenterology 7, no. 1 (January 2020): e000341. http://dx.doi.org/10.1136/bmjgast-2019-000341.

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ObjectiveThe concept of using naturally occurring compounds such as polyenylphosphatidylcholine (PPC) as an adjunctive therapy to treat non-alcoholic fatty liver disease (NAFLD) and alleviate or reverse hepatic steatosis appears a very attractive option for liver protection. We aim to evaluate if PPC adjunctive therapy can effectively improve the ultrasonographic features of NAFLD in routine clinical practice in Russian patients with cardiometabolic comorbidities.DesignThis 24-week, observational, prospective study was carried out in 174 medical sites across 6 federal districts of Russia. A total of 2843 adult patients with newly diagnosed NAFLD, who had a least one of four comorbidities, namely overweight/obesity, hypertension, type 2 diabetes mellitus and hypercholesterolaemia, and who received PPC as an adjunctive treatment to standard care, were enrolled. The assessment of liver ultrasonography was qualitative.ResultsOverall, 2263 (79.6%) patients had at least two metabolic comorbidities associated with NAFLD, and overweight/obesity was the most common comorbidity reported in 2298 (80.8%) patients. Almost all study participants (2837/2843; 99.8%) were prescribed 1.8 g of PPC administered three times daily. At baseline, the most frequently identified abnormalities on ultrasound were liver hyperechogenicity (84.0% of patients) and heterogeneous liver structure (62.9%). At 24 weeks, a significant (p<0.05) improvement in liver echogenicity and in liver structure was observed in 1932/2827 (68.3%) patients (95% CI 66.6% to 70.1%) and in 1207/2827 (42.7%) patients (95% CI 40.9% to 44.5%), respectively. The analysis of ultrasonographic signs by number of comorbidities revealed similar findings—liver echogenicity improved in 67.2%–69.3% and liver structure in 35.6%–45.3% of patients depending on the number of comorbidities.ConclusionThis study showed that PPC adjunctive therapy may be useful in improving the ultrasonographic features of NAFLD in patients with associated cardiometabolic comorbidities. It also supports evidence regarding the role of PPC in the complex management of NAFLD.
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9

Cao, Yi, Li Xu, Xiaohong Yang, Yuan Dong, Hongbin Luo, Fengling Xing, and Qiongxiang Ge. "The Potential Role of Cycloastragenol in Promoting Diabetic Wound Repair In Vitro." BioMed Research International 2019 (December 20, 2019): 1–10. http://dx.doi.org/10.1155/2019/7023950.

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Background. Refractory wound healing is a severe complication of diabetes with a significant socioeconomic burden. Whereas current therapies are insufficient to accelerate repair, stem cell-based therapy is increasingly recognized as an alternative that improves healing outcomes. The aim of the present study is to explore the role of cycloastragenol (CAG), a naturally occurring compound in Astragali Radix, in ameliorating refractory cutaneous wound healing in vitro, which may provide a new insight into therapeutic strategy for diabetic wounds. Methods. Human epidermal stem cells (EpSCs) obtained from nine patients were exposed to CAG, with or without DKK1 (a Wnt signaling inhibitor). A lentiviral short hairpin RNA (shRNA) system was used to establish the telomerase reverse transcriptase (TERT) and β-catenin knockdown cell line. Cell counting kit-8, scratch wound healing, and transwell migration assay were used to determine the effects of CAG in cell growth and migration. The activation of TERT, β-catenin, and c-Myc was determined using real-time qPCR and western blot analysis. Chromatin immunoprecipitation (ChIP) was performed to evaluate the associations among CAG, TERT, and Wnt/β-catenin signals. Results. CAG not only promoted the proliferation and migration ability of EpSCs but also increased the expression levels of TERT, β-catenin, c-Myc. These effects of CAG were most pronounced at a dose of 0.3 μM. Notably, the CAG-promoted proliferative and migratory abilities of EpSCs were abrogated in TERT and β-catenin-silenced cells. In addition, the ChIP results strongly suggested that CAG-modulated TERT was closely associated with the activation of Wnt/β-catenin signaling. Conclusion. Our data indicate that CAG is a TERT activator of EpSCs and is associated with their proliferation and migration, a role it may play through the activation of Wnt/β-catenin signaling.
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10

Houston, B., I. E. O'Neill, M. A. Mitchell, and C. Goddard. "Purification and biological activity of a single charge isomer of pituitary-derived chicken growth hormone." Journal of Endocrinology 125, no. 2 (May 1990): 207–15. http://dx.doi.org/10.1677/joe.0.1250207.

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ABSTRACT The chicken pituitary gland contains a number of naturally occurring, developmentally regulated forms of GH which have identical molecular weights but differ in their isoelectric points. In order to characterize their biological properties, each must be separated from non-GH proteins and other forms of GH. Chicken GH (cGH) was separated from other pituitary proteins by immunoaffinity chromatography using an anti-GH monoclonal antibody covalently linked to Sepharose 4B. The cGH eluted from this column as a single peak and migrated as a single band during sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), but showed multiple bands on isoelectric focussing. This material was chromatographed on a high-performance cation exchange column, and separation of charge isomers was monitored by a combination of isoelectric focussing and immunoblotting. Chicken GH eluted from this column in two distinct peaks. The minor peak (cGH P1) contained an isomer with an isoelectric point of 6·86 and the major peak (cGH P2) an isomer with an isoelectric point of 7·52. Each isomer migrated as a single band during isoelectric focussing and SDS-PAGE (Mr = 23 500), and as a single peak during high-performance gel permeation chromatography and reverse-phase high-performance liquid chromatography. Analysis of cGH P2 through 30 cycles in a gas-phase microsequencer gave an amino acid sequence identical to that predicted by translation of the GH complementary DNA nucleotide sequence. This single charge isomer increased the rate of lipolysis in chicken adipose tissue explants by about fourfold and was able to displace 125I-labelled cGH from binding sites in liver membranes with a dissociation constant of about 4 nmol/l. The output of insulin-like growth factor-I by hepatocytes in culture was increased from a basal rate of 50·4±11·6 (mean ± s.e.m.) to 787·9 ± 98·6 pg/6 × 106 cells per 48 h by two separate pulses of 1 μg cGH P2/ml. An i.v. injection of cGH P2 (15 μg/kg body weight) decreased the thyroxine:tri-iodothyronine ratio in serum of adult hens from 15·71 to 4·44, indicating an increase in 5′-monodeiodinase activity. These results demonstrate that the single most abundant charge isomer of chicken pituitary GH is likely to contain all the biological activity ascribed to the hormone. Journal of Endocrinology (1990) 125, 207–215
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Books on the topic "Reverse diabetes naturally"

1

Maas, Laurens. Curing diabetes in 7 steps: Take control of, and reverse your type two diabetes using functional medicine, naturally. Tucson, Arizona: Wheatmark, 2013.

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Heilbron, Roy. The 30-day diabetes cure: The proven step-by-step plan to reverse Type 2 diabetes naturally. Stamford, CT: Bottom Line Books, 2014.

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Montgomery, Baxter D. The food prescription for better health : a cardiologist's proven method to reverse heart disease, diabetes, obesity, and other chronic illnesses, naturally! Houston, Tex: Delworth Pub., 2011.

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Guthrie, Diana W. Diabetes self-management's hidden secrets of natural healing using foods, supplements, and more to slow and even reverse the complications of diabetes. New York: Diabetes Self-Management Books, 2006.

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Guthrie, Diana W. Diabetes self-management's hidden secrets of natural healing using foods, supplements, and more to slow and even reverse the complications of diabetes. New York: Diabetes Self-Management Books, 2006.

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Guthrie, Diana W. Diabetes self-management's hidden secrets of natural healing using foods, supplements, and more to slow and even reverse the complications of diabetes. New York: Diabetes Self-Management Books, 2006.

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Underwood, Sarah. Reverse Diabetes: Reverse Diabetes Naturally Without Drugs. Createspace Independent Publishing Platform, 2017.

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Whitfield, Eric. Halki Diabetes Remedy: How to Reverse Diabetes Naturally. Independently published, 2019.

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Teicholz, Nina, writer of foreword, ed. The diabetes code: Prevent and reverse type 2 diabetes naturally. Greystone Books, 2018.

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Cabot, Sandra. Diabetes Type 2: You Can Reverse It Naturally. WHAS Pty Limited, 2017.

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Conference papers on the topic "Reverse diabetes naturally"

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Dygert, Joseph P., Melissa L. Morris, Erik M. Messick, and Patrick H. Browning. "Feasibility of an Energy Efficient Large-Scale Aquaponic Food Production and Distribution Facility." In ASME 2014 8th International Conference on Energy Sustainability collocated with the ASME 2014 12th International Conference on Fuel Cell Science, Engineering and Technology. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/es2014-6567.

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Today the United States is plagued by societal issues, economic insecurity, and increasing health problems. Societal issues include lack of community inclusion, pollution, and access to healthy foods. The high unemployment coupled with the rising cost of crude oil derivatives, and the growing general gap between cost of living and minimum wage levels contribute to a crippled consumer-driven US economy. Health concerns include increasing levels of obesity, cardiovascular disease, cancer, and diabetes. These epidemics lead to staggering economic burdens costing Americans hundreds of billions of dollars each year. It is well-known that many of the health issues impacting Americans can be directly linked to the production, availability, and quality of the food. Factors contributing to the availability of food include reduction of United States farmland, an increase in food imported from overseas, and the cost of goods to the consumer. The quality of food is influenced by the method of growth as well as imposed preservation techniques to support food transportation and distribution. At the same time, it has become increasingly common to implement biotechnology in genetically modified crops for direct human food or indirectly as a livestock feed for animals consumed by humans. Crops are also routinely dosed with pesticides and hormones in an attempt to increase productivity and revenue, with little consideration or understanding of the long term health effects. Research shows that community gardens positively impact local employment, community involvement and inclusivity, and the diets of not only those involved in food production, but all members of their households. The purpose of this work is to determine the feasibility of an energy efficient large-scale aquaponic food production and distribution facility which could directly mitigate growing socioeconomic concerns in the US through applied best practices in sustainability. Aquaponics is a symbiotic relationship between aquaculture and hydroponics, where fish and plants grow harmoniously. The energy efficient facility would be located in an urban area, and employ solar panels, natural lighting, rain water reclamation, and a floor plan optimized for maximum food yield and energy efficiency. Examples of potential crops include multiple species of berries, corn, leafy vegetables, tomatoes, peppers, squash, and carrots. Potential livestock include responsibly farmed tilapia, shrimp, crayfish, and oysters. The large scale aquaponic facility shows a lengthy period for financial return on investment whether traditional style construction of the building or a green construction style is used. However many forms of federal government aid and outside assistance exist for green construction to help drive down the risk in the higher initial investment which in the long run could end up being more profitable than going with a traditionally constructed building. Outside of financial return there are many proven, positive impacts that a large-scale aquaponic facility would have. Among these are greater social involvement and inclusivity, job creation, increased availability of fresh food, and strengthening of America’s agriculture infrastructure leading to increased American independence.
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