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Journal articles on the topic 'Reverse diabetes naturally'

Author: Grafiati

Published: 14 December 2022

Last updated: 31 July 2025

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1

Scibilia, Renza. "The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally." Clinical Diabetes 37, no. 3 (2019): 302–3. http://dx.doi.org/10.2337/cd19-0025.

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Hassainya, Y., F. Garcia-Pons, R. Kratzer, et al. "Identification of Naturally Processed HLA-A2--Restricted Proinsulin Epitopes by Reverse Immunology." Diabetes 54, no. 7 (2005): 2053–59. http://dx.doi.org/10.2337/diabetes.54.7.2053.

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Bansal, Amita, and Rebecca A. Simmons. "Epigenetics and developmental origins of diabetes: correlation or causation?" American Journal of Physiology-Endocrinology and Metabolism 315, no. 1 (2018): E15—E28. http://dx.doi.org/10.1152/ajpendo.00424.2017.

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The incidence of metabolic disorders like type 2 diabetes (T2D) and obesity continue to increase. Although it is evident that the increasing incidence of diabetes confers a global societal and economic burden, the mechanisms responsible for the increased incidence of T2D are not well understood. Extensive efforts to understand the association of early-life perturbations with later onset of metabolic diseases, the founding principle of developmental origins of health and disease, have been crucial in determining the mechanisms that may be driving the pathogenesis of T2D. As the programming of t

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Randeria, Pratik S., Mark A. Seeger, Xiao-Qi Wang, et al. "siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown." Proceedings of the National Academy of Sciences 112, no. 18 (2015): 5573–78. http://dx.doi.org/10.1073/pnas.1505951112.

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Spherical nucleic acid (SNA) gold nanoparticle conjugates (13-nm-diameter gold cores functionalized with densely packed and highly oriented nucleic acids) dispersed in Aquaphor have been shown to penetrate the epidermal barrier of both intact mouse and human skin, enter keratinocytes, and efficiently down-regulate gene targets. ganglioside-monosialic acid 3 synthase (GM3S) is a known target that is overexpressed in diabetic mice and responsible for causing insulin resistance and impeding wound healing. GM3S SNAs increase keratinocyte migration and proliferation as well as insulin and insulin-l

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Yaneva-Sirakova, Teodora, Dobrin Vassilev, Kiril Karamfiloff, Julieta Hristova, Monika Shumkova, and Latchezar Traykov. "Clinical effect of carotid stenting on cognitive abilities - possible evaluation using candidates for biomarkers." Folia Medica 65, no. 2 (2023): 193–98. http://dx.doi.org/10.3897/folmed.65.e79996.

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Micro- and macrovascular consequences of atherosclerosis, arterial hypertension, dyslipidemia, and smoking can affect neurotransmission and markers for neuronal activity. The potential direction and specifics are under study. It is also known that optimal control of hypertension, diabetes, and dyslipidemia in midlife may positively affect cognitive functioning later in life. However, the role of hemodynamically significant carotid stenoses in neuronal activity markers and cognitive functioning is still being debated. With the increased use of interventional treatment for extracranial carotid d

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Wang, L.-J., M. Brännström, K.-H. Cui, et al. "Localisation of mRNA for interleukin-1 receptor and interleukin-1 receptor antagonist in the rat ovary." Journal of Endocrinology 152, no. 1 (1997): 11–17. http://dx.doi.org/10.1677/joe.0.1520011.

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Abstract Interleukin-1 (IL-1) is a multifunctional cytokine with profound effects on ovarian function. The effects of IL-1 on ovarian steroidogenesis have been demonstrated in several species. IL-1 mRNA levels are increased in the thecal layer of the ovulating follicle and IL-1β has been shown to induce ovulations in vitro. In this study we have investigated the presence and distribution of the mRNAs for type I IL-1 receptor (IL-1RtI) and for the naturally occurring IL-1 receptor antagonist (IL-1ra) in ovaries of adult cycling rats, to elucidate the target cells for IL-1 action. We have demons

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Jang, Eungyeong, and Jang-Hoon Lee. "Promising Anticancer Activities of Alismatis rhizome and Its Triterpenes via p38 and PI3K/Akt/mTOR Signaling Pathways." Nutrients 13, no. 7 (2021): 2455. http://dx.doi.org/10.3390/nu13072455.

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The flowering plant genus Alisma, which belongs to the family Alismataceae, comprises 11 species, including Alisma orientale, Alisma canaliculatum, and Alisma plantago-aquatica. Alismatis rhizome (Ze xie in Chinese, Takusha in Japanese, and Taeksa in Korean, AR), the tubers of medicinal plants from Alisma species, have long been used to treat inflammatory diseases, hyperlipidemia, diabetes, bacterial infection, edema, oliguria, diarrhea, and dizziness. Recent evidence has demonstrated that its extract showed pharmacological activities to effectively reverse cancer-related molecular targets. In

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Bolger, Graeme B., Mariana F. Bizzi, Sergio V. Pinheiro, et al. "cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors." Endocrine-Related Cancer 23, no. 5 (2016): 419–31. http://dx.doi.org/10.1530/erc-15-0205.

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PDE4 cyclic nucleotide phosphodiesterases regulate cAMP abundance in cells and therefore regulate numerous processes, including cell growth and differentiation. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein (also called XAP2 or ARA-9). Germline mutations inAIPoccur in approximately 20% of patients with Familial Isolated Pituitary Adenoma (FIPA) and 20% of childhood-onset simplex somatotroph adenomas. We therefore examined the protein expression of PDE4A4 and the closely related isoform PDE4A8 in normal human pituitary tissue and in pituitary adenomas. PDE4A4 had

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Maev, Igor V., Aleksey A. Samsonov, Liudmila K. Palgova, et al. "Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study)." BMJ Open Gastroenterology 7, no. 1 (2020): e000341. http://dx.doi.org/10.1136/bmjgast-2019-000341.

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ObjectiveThe concept of using naturally occurring compounds such as polyenylphosphatidylcholine (PPC) as an adjunctive therapy to treat non-alcoholic fatty liver disease (NAFLD) and alleviate or reverse hepatic steatosis appears a very attractive option for liver protection. We aim to evaluate if PPC adjunctive therapy can effectively improve the ultrasonographic features of NAFLD in routine clinical practice in Russian patients with cardiometabolic comorbidities.DesignThis 24-week, observational, prospective study was carried out in 174 medical sites across 6 federal districts of Russia. A to

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Cao, Yi, Li Xu, Xiaohong Yang, et al. "The Potential Role of Cycloastragenol in Promoting Diabetic Wound Repair In Vitro." BioMed Research International 2019 (December 20, 2019): 1–10. http://dx.doi.org/10.1155/2019/7023950.

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Background. Refractory wound healing is a severe complication of diabetes with a significant socioeconomic burden. Whereas current therapies are insufficient to accelerate repair, stem cell-based therapy is increasingly recognized as an alternative that improves healing outcomes. The aim of the present study is to explore the role of cycloastragenol (CAG), a naturally occurring compound in Astragali Radix, in ameliorating refractory cutaneous wound healing in vitro, which may provide a new insight into therapeutic strategy for diabetic wounds. Methods. Human epidermal stem cells (EpSCs) obtain

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Ahmed, Manal Hatem, Saja Ismail Karkush, Sumeia Abbas Ali, and Ali Abdulmawjood Mohammed. "Phytochemicals: a new arsenal in drug discovery." International Journal of Medical Science and Dental Health 10, no. 01 (2024): 29–44. http://dx.doi.org/10.55640/ijmsdh-10-01-03.

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In ancient times traditional herbs were used to treat different diseases such as stomach discomfort, toothache, body pain and inflammation, diarrhea, malaria, typhoid, diabetes, and so on. Medicinally important plants are recognized to have chemicals or phytochemicals that could be useful for illness treatment or medication manufacture. These compounds occur naturally in plant parts (leaves, stems, barks, and roots) and are referred to as secondary metabolites because, like primary metabolites, they are synthesized to protect the plant rather than for growth. Fortunately for humans, the majori

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Houston, B., I. E. O'Neill, M. A. Mitchell, and C. Goddard. "Purification and biological activity of a single charge isomer of pituitary-derived chicken growth hormone." Journal of Endocrinology 125, no. 2 (1990): 207–15. http://dx.doi.org/10.1677/joe.0.1250207.

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ABSTRACT The chicken pituitary gland contains a number of naturally occurring, developmentally regulated forms of GH which have identical molecular weights but differ in their isoelectric points. In order to characterize their biological properties, each must be separated from non-GH proteins and other forms of GH. Chicken GH (cGH) was separated from other pituitary proteins by immunoaffinity chromatography using an anti-GH monoclonal antibody covalently linked to Sepharose 4B. The cGH eluted from this column as a single peak and migrated as a single band during sodium dodecyl sulphate-polyacr

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Wicklow, Brandy, Kristy Wittmeier, Geert W. t’ Jong, et al. "Proposed trial: safety and efficacy of resveratrol for the treatment of non-alcoholic fatty liver disease (NAFLD) and associated insulin resistance in adolescents who are overweight or obese adolescents — rationale and protocol." Biochemistry and Cell Biology 93, no. 5 (2015): 522–30. http://dx.doi.org/10.1139/bcb-2014-0136.

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Non-alcoholic fatty liver (NAFL) disease (NAFLD) affects 30% of overweight adolescents and increases the risk of type 2 diabetes mellitus (T2D). Resveratrol is a naturally occurring compound with potential to reverse NAFL and its associated insulin resistance in adults. The use of resveratrol to reduce risk for T2D through its effect on NAFL has not been examined to date in youth. This paper provides a literature review and protocol for a 30 day proof of principle trial of resveratrol in a population of adolescents at risk for T2D. This randomized double-blind controlled trial is designed with

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Jia, Dong Mei, Akinari Tabaru, Hayato Nakamura, Ken-Ichiro Fukumitsu, Toshiharu Akiyama, and Makoto Otsuki. "Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes." Metabolism 49, no. 9 (2000): 1167–75. http://dx.doi.org/10.1053/meta.2000.8599.

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Dang, Lei, J. Paul Seale, and Xianqin Qu. "Effects of Hypocrellin A on Expression of Vascular Endothelial Growth Factor and Endothelin-1 in Human Umbilical Endothelial Cells." American Journal of Chinese Medicine 35, no. 04 (2007): 713–23. http://dx.doi.org/10.1142/s0192415x0700520x.

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Increased endothelin-1 (ET-1), vascular endothelial growth factor (VEGF) and activation of protein kinase C (PKC) are co-contributors to endothelial hyperpermeability in diabetes. Several lines of evidence have suggested a hypothesis that activation of specific PKC isoforms are the causative factor in ET-1 and VEGF mediated endothelial dysfunction. In the present study, we tested this hypothesis with hypocrellin A, a naturally occurring PKC inhibitor from a Chinese plant. Human umbilical vein endothelial cells (HUVECs) were incubated with 20 mM glucose in both the presence and absence of hypoc

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Catmull, Shawn, Faisal Masood, Sydney Schacht, et al. "Dietary Genistein Rescues Reduced Basal Chloride Secretion in Diabetic Jejunum via Sex-Dependent Mechanisms." Cellular Physiology and Biochemistry 40, no. 1-2 (2016): 335–46. http://dx.doi.org/10.1159/000452549.

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Background/Aims: The goal of this study was to determine the effect of dietary genistein (naturally occurring phytoestrogen) on jejunal secretory function in a clinically relevant model of diabetes and obesity, the leptin-defIcient ob/ob mouse. Methods: We measured transepithelial short circuit current (Isc), across freshly isolated segments of jejunum from 12-week old male and female ob/ob and lean C57Bl/6J mice fed a genistein diet (600 mg genistein/kg diet) for 4-weeks. Separate segments of jejunum were frozen for western blot determination of key proteins involved in secretory transport. R

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LUGG, JAMES A., DAVID F. PENSON, FARSHID SADEGHI, et al. "Prevention of Seminiferous Tubular Atrophy in a Naturally Cryptorchid Rat Model by Early Surgical Intervention." Journal of Andrology 17, no. 6 (1996): 726–32. http://dx.doi.org/10.1002/j.1939-4640.1996.tb01858.x.

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ABSTRACT: In an attempt to determine whether the seminiferous tubular atrophy of the cryptorchid testis is preventable by early surgical correction of the cryptorchid state, aberrantly developed gubemacula destined to result in a cryptorchid testis in the Long‐Evans cryptorchid (LE/ORL) rat were surgically reimplanted to the bottom of the scrotum on day 10 to 12 of age. Testis descent was monitored and the changes in testicular histology and in the volumes of the seminiferous tubules and Leydig cells were examined at day 60. As expected, normal testis descent occurred on or about day 25. Compa

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Wu, Yajun, Yao Wang, and Dongmin Liu. "Identification of Genipin as a Potential Treatment for Type 2 Diabetes." International Journal of Molecular Sciences 24, no. 3 (2023): 2131. http://dx.doi.org/10.3390/ijms24032131.

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The prevalence of type 2 diabetes (T2D) has been rising dramatically in many countries around the world. The main signatures of T2D are insulin resistance and dysfunction of β-cells. While there are several pharmaceutical therapies for T2D, no effective treatment is available for reversing the functional decline of pancreatic β-cells in T2D patients. It has been well recognized that glucagon-like peptide-1 (GLP-1), which is an incretin hormone secreted from intestinal L-cells, plays a vital role in regulating glycemic homeostasis via potentiating glucose-stimulated insulin secretion and promot

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Mutayoba, B. M., H. B. O'hara-Ireri, and S. Gombe. "Trypanosome-induced depression of plasma thyroxine Levels in prepubertal and adult female goats." Acta Endocrinologica 119, no. 1 (1988): 21–26. http://dx.doi.org/10.1530/acta.0.1190021.

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Abstract. Changes in plasma T4 levels were investigated in prepubertal and adult female goats during the course of an experimental Trypanosoma congolense infection. A significant decline in the T4 levels was observed within 1 week of trypanosome challenge. The levels remained low up to the end of the 7th weeks when prepubertal goats received a trypanocidal treatment, whereafter the values started to rise to normal pre-infection values. The post-infection plasma T4 values in the untreated adult goats did not return to normal except in one resistant goat which recovered naturally after 16 weeks

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Alkhalidy, Hana, William Moore, Yanling Zhang та ін. "Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreaticβ-Cell Mass in Middle-Aged Obese Diabetic Mice". Journal of Diabetes Research 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/532984.

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Insulin resistance and a progressive decline in functionalβ-cell mass are hallmarks of developing type 2 diabetes (T2D). Thus, searching for natural, low-cost compounds to target these two defects could be a promising strategy to prevent the pathogenesis of T2D. Here, we show that dietary intake of flavonol kaempferol (0.05% in the diet) significantly ameliorated hyperglycemia, hyperinsulinemia, and circulating lipid profile, which were associated with the improved peripheral insulin sensitivity in middle-aged obese mice fed a high-fat (HF) diet. Kaempferol treatment reversed HF diet impaired

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Schlinger, B. A., A. J. Fivizzani та G. V. Callard. "Aromatase, 5α- and 5β-reductase in brain, pituitary and skin of the sex-role reversed Wilson's phalarope". Journal of Endocrinology 122, № 2 (1989): 573–81. http://dx.doi.org/10.1677/joe.0.1220573.

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ABSTRACT While intrasexual competition for mates is generally considered to be an androgen-dependent characteristic of reproductively active males, in the Wilson's phalarope (Phalaropus tricolor) it is the female that acquires the brighter nuptial plumage and aggressively competes for access to the less aggressive males. Despite this pronounced sex-role reversal, circulating sex steroid hormones of breeding phalaropes are similar to those of avian species displaying traditional male–female reproductive roles. To investigate whether these behavioural and morphological steroid-dependent differen

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Martinez, Stephanie E., Casey L. Sayre, and Neal M. Davies. "Pharmacometrics of 3-Methoxypterostilbene: A Component of Traditional Chinese Medicinal Plants." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/261468.

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3-Methoxypterostilbene is a naturally occurring stilbene with potential in the treatment of diabetes. The preclinical pharmacokinetics and pharmacodynamics of 3-methoxypterostilbene were evaluated in the present study. The right jugular veins of male Sprague-Dawley rats were cannulated. The rats were dosed 10 mg/kg or 100 mg/kg of 3-methoxypterostilbene intravenously (IV) or orally (PO), respectively. Serum and urine samples were analyzed using a previously validated reversed-phase HPLC method. Serum AUC, serumt1/2, urinet1/2,Cltotal, and Vd for IV dosing were48.1±23.8 μg/h/mL,18.9±10.9 h,9.54

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Ali, Muhammed Yusuf, Matthew Whiteman, Chian-Ming Low, and Philip K. Moore. "Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway." Journal of Endocrinology 195, no. 1 (2007): 105–12. http://dx.doi.org/10.1677/joe-07-0184.

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Hydrogen sulphide (H2S), a naturally occurring gas exerts physiological effects by opening KATP channels. Anti-diabetic drugs (e.g. glibenclamide) block KATP channels and abrogate H2S-mediated physiological responses which suggest that H2S may also regulate insulin secretion by pancreatic β-cells. To investigate this hypothesis, insulin-secreting (HIT-T15) cells were exposed to NaHS (100 μM) and the KATP channel-driven pathway of insulin secretion was tracked with various fluorescent probes. The concentration of insulin released from HIT-T15 cells decreased significantly after NaHS exposure an

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Steuer, Andrea E., Justine Raeber, Fabio Simbuerger, et al. "Towards Extending the Detection Window of Gamma-Hydroxybutyric Acid—An Untargeted Metabolomics Study in Serum and Urine Following Controlled Administration in Healthy Men." Metabolites 11, no. 3 (2021): 166. http://dx.doi.org/10.3390/metabo11030166.

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In forensic toxicology, gamma-hydroxybutyrate (GHB) still represents one of the most challenging drugs of abuse in terms of analytical detection and interpretation. Given its rapid elimination, the detection window of GHB in common matrices is short (maximum 12 h in urine). Additionally, the differentiation from naturally occurring endogenous GHB, is challenging. Thus, novel biomarkers to extend the detection window of GHB are urgently needed. The present study aimed at searching new potential biomarkers of GHB use by means of mass spectrometry (MS) metabolomic profiling in serum (up to 16.5 h

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Lee, Eun-Jung, Min-Kyung Kang, Yun-Ho Kim, et al. "Coumarin Ameliorates Impaired Bone Turnover by Inhibiting the Formation of Advanced Glycation End Products in Diabetic Osteoblasts and Osteoclasts." Biomolecules 10, no. 7 (2020): 1052. http://dx.doi.org/10.3390/biom10071052.

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Accumulating evidence demonstrates that the risk of osteoporotic fractures increases in patients with diabetes mellitus. Thus, diabetes-induced bone fragility has recently been recognized as a diabetic complication. As the fracture risk is independent of the reduction in bone mineral density, deterioration in bone quality may be the main cause of bone fragility. Coumarin exists naturally in many plants as phenylpropanoids and is present in tonka beans in significantly high concentrations. This study investigated whether coumarin ameliorated the impaired bone turnover and remodeling under diabe

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Bang, EunJin, Cheol Park, Hyun Hwangbo та ін. "Spermidine Attenuates High Glucose-Induced Oxidative Damage in Retinal Pigment Epithelial Cells by Inhibiting Production of ROS and NF-κB/NLRP3 Inflammasome Pathway". International Journal of Molecular Sciences 24, № 13 (2023): 10550. http://dx.doi.org/10.3390/ijms241310550.

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Diabetic retinopathy (DR) is the leading cause of vision loss and a critical complication of diabetes with a very complex etiology. The build-up of reactive oxygen species (ROS) due to hyperglycemia is recognized as a primary risk factor for DR. Although spermidine, a naturally occurring polyamine, has been reported to have antioxidant effects, its effectiveness in DR has not yet been examined. Therefore, in this study, we investigated whether spermidine could inhibit high glucose (HG)-promoted oxidative stress in human retinal pigment epithelial (RPE) cells. The results demonstrated that sper

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Kang, Min-Kyung, Eun-Jung Lee, Yun-Ho Kim, et al. "Chrysin Ameliorates Malfunction of Retinoid Visual Cycle through Blocking Activation of AGE-RAGE-ER Stress in Glucose-Stimulated Retinal Pigment Epithelial Cells and Diabetic Eyes." Nutrients 10, no. 8 (2018): 1046. http://dx.doi.org/10.3390/nu10081046.

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Diabetes-associated visual cycle impairment has been implicated in diabetic retinopathy, and chronic hyperglycemia causes detrimental effects on visual function. Chrysin, a naturally occurring flavonoid found in various herbs, has anti-inflammatory, antioxidant, and neuroprotective properties. The goal of the current study was to identify the retinoprotective role of chrysin in maintaining robust retinoid visual cycle-related components. The in vitro study employed human retinal pigment epithelial (RPE) cells exposed to 33 mM of glucose or advanced glycation end products (AGEs) in the presence

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Murugan, Pidaran, and Sivaprakasam Maneemegalai. "Effect of Tetrahydrocurcumin Compared to Curcumin in Carbohydrate Metabolism and Glycoprotein Components in Type 2 Diabetes - Systematic Review." Journal of Advanced Zoology 44, S7 (2023): 157–67. http://dx.doi.org/10.17762/jaz.v44is7.2748.

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Pancreatic β-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes mellitus. Treatment of diabetes without any side effects is still a challenge to the medical system. There is an increasing demand by patients to use the natural products with antidiabetic activity, because insulin and oral hypoglycemic drugs are having so many side effects. Curcumin is a biologically active component isolated from the rhizome of Curcuma longa that possess antidiabetic and has been proven scientifically to possess high antioxidant activity and anticancer properties. Tetrahydrocurcumin

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Kim, Dong Yeon, Sin-Hye Park, Zaee Yoon, Jimin Kim, Min-Kyung Kang, and Young-Hee Kang. "Eucalyptol Ameliorates Retinal Microvascular Defects through Modulating ER Stress and Angiopoietin–Tie Signaling in Diabetic Eyes." International Journal of Molecular Sciences 25, no. 14 (2024): 7826. http://dx.doi.org/10.3390/ijms25147826.

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Loss of the inner blood–retinal barrier (BRB) integrity is a main feature of ocular diseases such as diabetic macular edema. However, there is a lack of clarity on how inner BRB function is modulated within the diabetic retina. The current study examined whether eucalyptol inhibited inner BRB destruction and aberrant retinal angiogenesis in 33 mM glucose-exposed human retinal microvascular endothelial (RVE) cells and db/db mice. This study further examined the molecular mechanisms underlying endothelial dysfunction including retinal endoplasmic reticulum (ER) stress and angiopoietin (Ang)/Tie

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Rico-Fontalvo, Jorge, Rodrigo Daza-Arnedo, Tomas Rodríguez-Yanez, et al. "Obesidad y enfermedad renal crónica. Una mirada desde los mecanismos fisiopatológicos." Revista de la Sociedad Ecuatoriana de Nefrología, Diálisis y Trasplante 10, no. 2 (2022): 97–107. http://dx.doi.org/10.56867/32.

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Introducción: La enfermedad renal crónica asociada a la obesidad (ERC-AO) es una enfermedad con aumento en la prevalencia en las últimas décadas. Se caracteriza por un exceso de desequilibrios hormonales adipocíticos (adipoquinas), desregulación del sistema de equilibrio energético y desequilibrios en la homeostasis metabólica. Propósito de la revisión: El objetivo de la revisión es delinear el papel de los diferentes mecanismos fisiopatológicos para el desarrollo de enfermedad renal funcional o anatómica en pacientes con obesidad. Buscamos reportes actualizados en donde se incluye los resulta

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Rahman, Sezanur, M. Mahfuzur Rahman, Mojnu Miah, et al. "COVID-19 reinfections among naturally infected and vaccinated individuals." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-05325-5.

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AbstractThe protection against emerging SARS-CoV-2 variants by pre-existing antibodies elicited due to the current vaccination or natural infection is a global concern. We aimed to investigate the rate of SARS-CoV-2 infection and its clinical features among infection-naïve, infected, vaccinated, and post-infection-vaccinated individuals. A cohort was designed among icddr,b staff registered for COVID-19 testing by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR). Reinfection cases were confirmed by whole-genome sequencing. From 19 March 2020 to 31 March 2021, 1644 (mean age,

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Sherif, Sara Gamal, Marwa Tarek, Yasmine Gamal Sabry, and Azza Hassan AbouGhalia. "Role of Apigenin in Rats with Type 1 Diabetic Complications." QJM: An International Journal of Medicine 117, Supplement_1 (2024). http://dx.doi.org/10.1093/qjmed/hcae070.104.

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Abstract Background and Aim The main factor contributing to diabetes morbidity and mortality is cardiovascular problems. Apigenin, a naturally occurring flavonoid with anti-inflammatory and anti-diabetic characteristics, was investigated for its cardioprotective potential. Methods Type 1 diabetes model was induced using single injection of streptozotocin and diabetic rats were injected with apigenin. ECG recording and measurement of blood pressure were performed. Biochemical analyses of serum glucose, lipid profile, and creatine kinase were done. Histological examination of cardiac tissues was

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OKADA, JUNICHI, AUSTIN LANDGRAF, MAXWELL HORTON, et al. "207-OR: ADA Presidents' Select Abstract: Identification of a Novel Hepatocyte Subpopulation That Normally Displays Selective Hepatic Insulin Resistance." Diabetes 74, Supplement_1 (2025). https://doi.org/10.2337/db25-207-or.

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Introduction and Objective: Selective hepatic insulin resistance is a central paradox in the pathogenesis of type 2 diabetes, where insulin fails to inhibit gluconeogenesis but continues to stimulate de novo lipogenesis, causing hyperglycemia and hypertriglyceridemia. In our studies with scRNA-seq and smFISH, we have identified a subpopulation of hepatocytes in normal physiologic conditions that resemble selective hepatic insulin resistance (termed DM hepatocytes). To understand the mechanism of hepatic insulin resistance, we analyzed this subpopulation of hepatocytes. Methods: We quantified t

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Cattaneo, Monica, Antonio P. Beltrami, Anita C. Thomas, et al. "The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy." Cardiovascular Research, January 13, 2023. http://dx.doi.org/10.1093/cvr/cvad008.

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Abstract Aims The aging heart naturally incurs a progressive decline in function and perfusion that available treatments cannot halt. However, some exceptional individuals maintain good health until the very late stage of their life due to favourable gene-environment interaction. We have previously shown that carriers of a longevity-associated variant (LAV) of the BPIFB4 gene enjoy prolonged health spans and lesser cardiovascular complications. Moreover, supplementation of LAV-BPIFB4 via an adeno-associated viral vector improves cardiovascular performance in limb ischemia, atherosclerosis, and

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Tobi, Dror, Eilon Krashin, Paul J. Davis, Vivian Cody, Martin Ellis та Osnat Ashur-Fabian. "Three-Dimensional Modeling of Thyroid Hormone Metabolites Binding to the Cancer-Relevant αvβ3 Integrin: In-Silico Based Study". Frontiers in Endocrinology 13 (27 травня 2022). http://dx.doi.org/10.3389/fendo.2022.895240.

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BackgroundThyroid hormones (TH), T4 and T3, mediate pro-mitogenic effects in cancer cells through binding the membrane receptor αvβ3 integrin. The deaminated analogue tetrac effectively blocks TH binding to this receptor and prevents their action. While computational data on TH binding to the αvβ3 integrin was published, a comprehensive analysis of additional TH metabolites is lacking.MethodsIn-silico docking of 26 TH metabolites, including the biologically active thyroid hormones (T3 and T4) and an array of sulfated, deiodinated, deaminated or decarboxylated metabolites, to the αvβ3 receptor

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Harris, Janay M., and Mitsi A. Blount. "Polyphenolics Protect Renal Fibroblasts from the Harmful Effects of Hyperglycemia‐Stimulated Advanced Glycation End Products." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.716.5.

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Diabetes mellitus is the most common metabolic disease and a leading cause of kidney failure. Chronic hyperglycemia leads to non‐enzymatic glycation of proteins to form advanced glycation end products (AGEs), a major culprit in the progression of diabetic nephropathy (DN). AGEs promote DN by inducing secretion of cytokines and growth factors, as well as mediate tubulointerstitial fibrosis, via the receptor for AGEs (RAGE). Herbs and spices contain high concentrations of polyphenolics which block AGE formation. The aim of this study was to determine if a mixture of culinary spices with high phe

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El-Sayed, Norhan S., Soha Elatrebi, Rasha Said, Heba F. Ibrahim, and Eman M. Omar. "Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action." Metabolic Brain Disease, July 4, 2022. http://dx.doi.org/10.1007/s11011-022-01035-z.

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AbstractCognitive impairment is considered as a typical feature of neurodegenerative diseases in diabetes mellitus (DM). However, the exact link between cognitive dysfunction and diabetes mellitus is still vague. This study aims to investigate some of the mechanisms underlying cognitive impairment that associates diabetes mellitus and insulin resistance. We investigated the role of resveratrol as well on cognitive function in experimentally induced type 2 diabetes highlighting on its influence on the expression of brain miRNA 21. Resveratrol is a naturally occurring, biologically active compou

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"Synergistic Efficacy of Aframomum Melegueta [Roscoe] K. Schum and Spondias mombin (Linn), a Predictive Treatment of SARS-CoV-2 (COVID-19) Infection." Journal of Bioscience & Biomedical Engineering, July 20, 2020. http://dx.doi.org/10.47485/2693-2504.1013.

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SARS-CoV-2 is closely related to the original SARS-CoV. It is thought to have animal based origin from Bats(Betacoronavirus) in subgenus (Sarbecoronavirus) together with two bat-derived strains The virus is mainly spread between people during physical contact, often through small droplets produced during coughing, sneezing, even talking to patient or infected people. It is primarily spread during close contact and via small droplets produced when infected people cough, sneeze or talk with close contact being within 1–3 m (3 ft 3 in–9 ft 10 in). Those infected with the virus may be asymptomatic

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Kleissl-Muir, Sabine, Bodil Rasmussen, Alice Owen, Caryn Zinn, and Andrea Driscoll. "Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis." Frontiers in Nutrition 9 (April 20, 2022). http://dx.doi.org/10.3389/fnut.2022.865489.

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Elevated blood glucose levels, insulin resistance (IR), hyperinsulinemia and dyslipidemia the key aspects of type 2 diabetes mellitus (T2DM), contribute to the development of a certain form of cardiomyopathy. This cardiomyopathy, also known as diabetic cardiomyopathy (DMCM), typically occurs in the absence of overt coronary artery disease (CAD), hypertension or valvular disease. DMCM encompasses a variety of pathophysiological processes impacting the myocardium, hence increasing the risk for heart failure (HF) and significantly worsening outcomes in this population. Low fat (LF), calorie-restr

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