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Dissertations / Theses on the topic 'RFT tool'

Author: Grafiati

Published: 3 June 2025

Last updated: 13 July 2025

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1

Lin, Chungping. "The RMT (Recursive multi-threaded) tool: A computer aided software engineeering tool for monitoring and predicting software development progress." CSUSB ScholarWorks, 1998. https://scholarworks.lib.csusb.edu/etd-project/1787.

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2

Pigatto, Leonardo. "Advanced Tools for Three-Dimensional Modeling and Control of Thermonuclear Fusion Devices." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422889.

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This thesis represents the summary of the research activities carried out during a three-years Ph.D. project. The work is divided into two parts, with the common feature of investigating the physical properties related to stability and control of Magneto-Hydro-Dynamic modes in fusion relevant plasmas. One of the aims of the work is to better understand the interaction between such plasmas and a wide range of 3-dimensional electro-magnetic boundary conditions. This part of the research has been carried out on the RFX-mod device, where advanced control strategies have been developed thanks to its state-of-the-art magnetic feedback system. A variety of interlaced problems have been addressed, starting with the improvement of the vacuum magnetic field spectrum through actuator-sensor decoupling, compensation of broken or deactivated coils with simple and real-time applicable strategies and multi-modal Resistive Wall Mode control with varying coil number and geometry. This has allowed to develop relevant control optimization techniques and knowledge for both the Reversed Field Pinch and Tokamak configurations. The former is an excellent playground for RWM studies, given the instability spectrum that is naturally developing. For the latter configuration instead, RWM stability is considered to be one major milestone to be achieved along the road to a commercial fusion reactor. The second part of the work is dedicated to this issue, and deals with the stability properties of Advanced Tokamak scenarios, with reference to the JT-60SA experiment in particular. Studies to understand RWM physics in high beta plasmas, where fluid rotation profiles and hot ions populations from Neutral Beams can play an important role, have been carried out with the MARS-F/K linear MHD codes. If detailed physics such as kinetic effects is coupled to a simplified description of the passive/active structures on one side, on the other hand a simplified plasma can be coupled to a complex 3-D model of the structures to assess realistic active control capabilities of a given system. Different tools are used and described for studying RWM damping physics, and to five a proof-of-principle for feedback control of such instabilities in Advanced Tokamak plasmas operating beyond the no-wall pressure limit.<br>Questa tesi rappresenta la raccolta delle attività svolte durante i tre anni di un progetto di Dottorato di Ricerca. Il lavoro è stato diviso principalmente in due parti, con il comune denominatore di investigare le problematiche relative alla stabilità e al controllo di instabilità Magneto-Idro-Dinamiche in plasmi di interesse fusionistico. Uno dei principali obiettivi di questo lavoro è lo studio di come questi plasmi interagiscano con diverse condizioni al contorno, strutturali ed elettro-magnetiche, con caratteristiche tridimensionali. Questa parte della ricerca è stata svolta sull'esperimento RFX-mod, dove è stato possibile sviluppare peculiari strategie di controllo grazie all'avanzato sistema di controllo attivo. Sono state affrontate varie problematiche tra loro interconnesse, a partire dallo sviluppo di tecniche per il miglioramento del contenuto armonico dei campi magnetici di vuoto tramite disaccoppiamento attuatori-sensori. Da ciò è stato sviluppato un metodo semplificato e applicabile in tempo reale per la compensazione di attuatori rotti o disattivati, con il medesimo obiettivo di migliorare il contenuto armonico dei campi magnetici prodotti dal sistema di controllo reale. A conclusione di questa parte il controllo multi-modale di modi di parete resistiva (RWM) è stato affrontato, dal punto di vista modellistico e sperimentale. Le strategie sviluppate e gli studi effettuati sono rilevanti sia per la configurazione Reversed Field Pinch sia per il Tokamak. Il primo è un ottimo terreno di prova per studiare i modi RWM, per via dello spettro di instabilità che naturalmente sviluppa. Per la seconda configurazione invece, la stabilizzazione dei modi RWM è considerato uno dei principali obiettivi da raggiungere sulla strada verso un reattore a fusione commerciale. La seconda parte del lavoro è relativa proprio alla problematica della stabilità RWM nella configurazione Tokamak, in particolar modo negli scenari avanzati in fase di sviluppo per l'esperimento JT-60SA. Una serie di studi è stata portata avanti con i codici MARS-F/K per determinare le proprietà dei modi RWM in plasmi ad alto beta, nei quali i profili di rotazione e le popolazioni di ioni sovra termici provenienti dagli iniettori di neutri possono giocare un ruolo importante. Da un lato una descrizione dettagliata del plasma, includendo gli effetti cinetici, è stata accoppiata a un modello semplificato e bidimensionale delle strutture passive. D'altra parte una più semplice descrizione del plasma è stata considerata per l'accoppiamento con un modello dettagliato e tridimensionale delle strutture attive e passive, in quest'ultimo caso è stato possibile sviluppare un modello di controllo attivo in catena chiusa dei modi RWM.

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3

Sjöström, Elin. "Virtual Reality as a Sales Tool for Industrial Companies." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-105504.

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To display large and complex products at sales meetings or fairs can be a challenge for industrial companies. Customers want to experience the product before purchase, yet this is not always possible due to high shipping costs and logistic problems. Virtual Reality (VR) achieved by Head-mounted Displays (HMD) is growing bigger by every day and is becoming accessible to more people. With this technology, there must be a new way to facilitate the sales process in the industry. The ﬁrst goal with this master thesis was to investigate what challenges and opportunities there are in today’s sales process and develop a concept for a sales tool that uses the VR technology. The second goal was to explore how today’s technology could evolve and how the future sales process could work. To achieve these goals the Research Learning Spiral was used together with interviews and a workshop. By investigating how the sales process works in today’s industry, through interviews with people that are active in the ﬁeld and a workshop, a number of challenges were identiﬁed. Three of these challenges were: to display large and complex products to the customers, to know what arguments that triggers a speciﬁc customer and to explain advantages with the product to the customer. Based on data from the interviews a prototype of a sales tool using VR was designed. The goal with the prototype was to counteract the challenges found in today’s sales process. The prototype uses a tablet where the salesman can control a 3D visualization of the product through a menu with diﬀerent choices. This tablet is connected to the Samsung Gear VR, which is a VR device that uses a HMD to achieve VR, where the customer can experience the product in a virtual environment controlled by the salesman. With data from the interviews together with a conducted workshop, suggestions for the future sales process were obtained. The future sales process is very likely to use VR as a tool to both display products and to reduce traveling. The technology will possibly be smarter and be able to facilitate the sales process, for instance through artiﬁcial intelligence, smart materials and 3D printing. VR as a sales tool for large and complex products has the potential to be a great aid for the salesman during the sales process. Companies will not be required to ship large and complex products to fairs or meetings which will save money for the company and also contribute to less impact on the environment. This area of research is fairly new and there are a lot of opportunities still to be investigated.

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4

White, Paul. "An immersive virtual reality navigational tool for diagnosing and treating neurodegeneration." Libertas, 2016. http://hdl.handle.net/1993/31979.

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One of the earliest symptoms of Alzheimer’s Disease (AD) is a loss of spatial navigation. In this work, we improved an existing screening test for AD that analyzed a patient’s spatial navigation ability. The existing screening test was made more immersive, and therefore more reliable, by integrating support for a leading-edge consumer-targeted Head-Mounted Display (HMD). This integration brought some technical and usability challenges, that were addressed. Furthermore, we investigated the rehabilitative potential of Virtual Reality Navigational (VRN) activities in two case studies: an Early Stage AD (ESA) participant and a Late Stage AD (LSA) participant. We found that the ESA participant was able to significantly improve his navigation skills, and we observed some qualitative improvements in memory and navigation in his personal life. The LSA participant did not improve noticeably at the VRN tasks, but his mood improved after participating in the treatment sessions. These case studies suggested that VRN treatment may be beneficial for people with AD, especially at the onset stage.<br>February 2017

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5

Bolat, Murat. "Instrumentation tool for context-aware optimization." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 64 p, 2009. http://proquest.umi.com/pqdweb?did=1885467641&sid=5&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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6

DUNKER, PHILIP KUSTER. "A LOW-COST TELEPRESENCE TOOL USING OCULUS RIFT: DEVELOPMENT AND EVALUATION IN A VIDEOCONFERENCE SCENARIUM." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2016. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=27726@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR<br>PROGRAMA DE EXCELENCIA ACADEMICA<br>Telepresença refere-se a um conjunto de tecnologias que permite uma pessoa se sentir como se estivesse presente em um lugar que não seja a sua verdadeira localização. Esses equipamentos costumam usar uma câmera comum para filmar o que está acontecendo em um ambiente e transmitir ao vivo em televisões ou monitores para o usuário em outro ambiente. Algumas vezes as câmeras podem ser controladas através de dispositivos como teclado ou joysticks. Neste trabalho apresentamos uma ferramenta composta por um head-mounted display (HMD), o Oculus Rift DK1, integrado com um dispositivo nomeado de cabeça remota (CR), capaz de filmar usando uma câmera estéreo e transmitir para o Oculus Rift as imagens em 3D. Ao mesmo tempo, o giroscópio do HMD captura a orientação da cabeça do usuário e envia para a cabeça remota, que possui servo motores capazes de girá-la a fim de possibilitar o usuário movimentar a câmera estéreo sem nenhum dispositivo adicional. O objetivo é proporcionar uma experiência de telepresença imersiva, com uma interface de baixo custo e simples de usar. Foram realizados testes com usuários com cenários experimentais, que indicaram o benefício da ferramenta em videoconferências.<br>Telepresence refers to a set of technologies that allows a person to feel as if he is in a place other than his true location. Such equipment uses an ordinary camera to film what is happening in an environment and transmits it alive on televisions or monitors to the user in another environment. Sometimes the cameras can be controlled through devices such as keyboards or joysticks. This dissertation presents a tool composed of a head-mounted display (HMD), we used the Oculus Rift DK1, integrated with a device called remote head, able to film with a stereo camera and to transmit to the Oculus Rift the images in 3D. At the same time, the HMD s gyroscope captures the user s head orientation and sends it to the remote head, which has servo motors able to rotate it in order to allow the user to move the stereo camera without any additional device. The project s goal is to provide the user an experience of immersive telepresence, with a low cost and a simple interface. Some tests with users were performed and indicated the benefit of the tool for videoconferencing.

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7

Kuo, Yi-Chiun. "Multi-database support in the recursive multi-threaded software process management tool." CSUSB ScholarWorks, 2002. https://scholarworks.lib.csusb.edu/etd-project/2266.

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The Recursive Multi-Threaded (RMT) software process management tool gives software developers the following capabilities: break a large project into a sequence of prototypes (or threads) track these threads individually, and estimate the progress and completion date of the project from these individual threads. The goal of this project is to provide the RMT Tool with an ability to support multi-database for collaborative software development. As a demonstration, actual data is used from several previous algorithma projects.

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8

Villa, Victor Fidel. "EVALUATION OF DESIGN TOOLS FOR THE MICRO-RAM AIR TURBINE." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1446.

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The development and evaluation of the design of a Micro-Ram Air Turbine (µRAT), a device being developed to provide power for an autonomous boundary layer measurement system, has been undertaken. The design tools consist of a rotor model and a generator model. The primary focus was on developing and evaluating the generator model for the prediction of generator brake power and output electrical power with and without rectification as a function of shaft speed and electrical load, with only basic manufacturer specifications given as inputs. A series of motored generator evaluation test were conducted at speeds ranging from 9,000 to 25,000 rpm for loads varying between 1 and 3.02 Ohms with output power of up to 80 Watts. Results demonstrated that predicted generated power was at or below 3% error when compared to measured results with about 1% uncertainty. A rotor model was also developed using basic blade element theory. This model neglected induced flow effects and was therefore expected to over predict rotor torque and power. A second rotor model that includes induced flow effects, the open source program X-Rotor, was also used to predict rotor power and for comparison to the blade element rotor model results. Both rotor models were evaluated through wind tunnel validation tests conducted on a turbine generator with two different 3.25 in diameter rotors, rotor-1 (untwisted blades) and rotor-2 (twisted blades). Wind tunnel validation test airspeeds varied between 71-110 mph with electrical loads ranging from 1-20 ohms. Results indicated power predictions to be 50-75% higher for the blade element model and 20-30% for X-Rotor results. The blade element rotor model was modified by applying the Prandtl tip-loss factor to approximately account for the induced flow effects; this addition brought predictions much closer to X-Rotor results. Based on the motor-driven generator test results, it is believed that most of the discrepancy in baseline rotor/generator validation test between predicted and observed power generated is due to inaccuracy in the rotor performance modelling with likely contributors to error being induced flow effects, crude section lift/drag modelling, and aero-elastic deformation. It is concluded that the proposed generator model is sufficient although direct torque measurements may be desired and further development of the µRAT design tools should focus on an improved rotor performance model.

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9

Baietto, M. "Development of a new non-invasive tool for the assessment of decays in the urban environment." Doctoral thesis, Università degli Studi di Milano, 2007. http://hdl.handle.net/2434/161509.

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The problem of tree stability in the urban environment is one of the main worries of our public administrations. The very bad conditions in which plants live in the cities force them to endure perennial stress, many various pests, and damage from accidental injuries. Currently, the stability methodology assessment in the urban environment initially follows a visual analysis of individual trees pursued by an evaluation of the internal state by using different instruments that are feasible but often invasive, expensive, or cannot be used in the urban environment. Moreover, many of these instruments do not provide an adequate evaluation if the decay occurs in the root system. We have evaluated the possibility of integrating the tools currently used with an innovative one developed in other fields for different applications: the electronic nose and its capability to detect volatiles emitted by the wood decay fungi, the healthy trees and the diseased trees. Results showed the feasibility of using three different e-noses for detecting incipient decays in artificially inoculated wood. A previous objective was to evaluate the progress kinetics of decays in trees in order to develop provisional models and that are reliable and applicable. Our data confirm that A. mellea and G. lucidum have the fastest growth rates among common urban wood decay fungi but Thuja occidentalis L. seems resistant or at least tolerant to many wood decay fungi based on artificial inoculations. Platanus x acerifolia appeared to be the most susceptible species of all ornamental tree species tested.

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10

Matheron, Michael E., and Martin Porchas. "Evaluation of Fungicides as Potential Management Tools for Phytophthora Crown Rot on Pepper Plants." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2006. http://hdl.handle.net/10150/215030.

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Phytophthora blight of peppers (Capsicum annuum) is caused by the oomycete pathogen Phytophthora capsici. In Arizona, the root and crown rot phase of the disease initially can appear on plants early in the growing season in areas of the field where soil remains saturated with water after an irrigation or rainfall event. Disease severity can increase dramatically due to summer rains during July and August in the southeastern Arizona production area. The efficacy of the systemic fungicide mefenoxam (Ridomil Gold)) for control of Phytophthora blight on pepper has been documented; however, in many pepper production regions, populations of the pathogen insensitive to this fungicide have developed. Other chemistries, including dimethomorph (Acrobat) as well as some new fungicides in development, have activity on some species of Phytophthora and associated diseases on crops other than pepper. The objective of the following study was to evaluate additional chemistries for efficacy in suppressing development of root and crown rot on pepper plants grown in soil naturally infested with Phytophthora capsici. In the first trial, nontreated pepper plants were all dead after an average elapsed time of 5 days in soil infested with P. capsici. In the same trial, no plants died after 66 days when the soil was treated with Ranman (cyazofamid), V-10161 (fluopicolide), and Reason (fenamidone) + Previcur Flex (propamocarb). Additionally, only one out of five pepper plants died when treated with Omega (fluazinam), NOA-446510 (mandipropamid) and AgriFos (mono- and di-potassium salts of phosphorous acid). For all of these treatments, the duration of plant survival and fresh weight of plant shoots and roots did not differ significantly from plants grown in sterilized soil. Similar results were obtained in the second trial. The results from these trials suggest that several fungicides currently not registered for use on peppers may be effective components of a management program for Phytophthora root and crown rot. The data is promising; however, additional studies in field soil naturally infested with P. capsici are needed to confirm the preliminary findings of these initial experiments.

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11

Harwood, Amanda D. "Temperature as a toxicity identification evaluation tool for pyrethroid insecticides : toxicokinetic confirmation /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1594480611&sid=9&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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12

CAMBIANICA, ILARIA NADIA. "In vitro blood brain barrier models as a screening tool for brain targeted nanobased drug delivery systems." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/39834.

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The blood brain barrier (BBB) is a selective biological barrier located at the brain capillaries, that protects the central nervous system (CNS) by monitoring exchanges between blood and brain. The BBB controls and regulates the composition of the CNS environment and it still constitutes the main obstacle for drug delivery to the brain (Weiss N. et al., 2009). The significant scientific and industrial interest in the physiology and pathology of the BBB led to the development of vast number of in vitro BBB models. Even though no “ideal” model exists yet, some of the currently available ones are very useful to investigate permeability, transport mechanisms and cellular and molecular events which occur at the BBB level. New strategies for brain targeted drug delivery exploit endogenously expressed transporters to elicit drug passage across the BBB. Among them, nanoparticles represent a promising tool, since they are biocompatible and biodegradable, and they can be functionalized to target the BBB (De Boer A.G. and Gaillard P.J., 2007) (Beija M et al., 2012; Caruthers S.D. et al., 2007; Moghimi S.M. et al., 2005). In this study we settled in vitro BBB models to identify, with high-throughput screening, the most promising nanoliposomes (NL) for combined BBB crossing and binding of amyloid peptides, for joint therapy and diagnosis of Alzheimer’s disease (AD). Firstly, we characterized two in vitro models of BBB, based on immortalized cell lines of human and rat origin, the hCMEC/D3 and RBE4 cells, respectively. We tested the transendothelial electrical resistance (TEER) and the endothelial permeability (PE) of small hydrophilic compounds: our results, in agreement with data reported in literature, lead us to conclude that these cellular models are suitable for their employment as high-throughput screening tools. Subsequently, we tested NL mono-functionalized with three different peptides, the apolipoproteinE derived peptide (the ApoE monomer (mApoE), amino acids 141-150), its tandem dimer (dApoE) (141-150)2, and the Human Immunodeficency Virus type 1 (HIV-1) transactivator of transcription (TAT) peptide. We evaluated their uptake and PE; we selected the TAT functionalization as the best performing concerning cellular uptake, and the mApoE functionalization when considering both the internalization and PE. Once assessed the dynamics of mono-functionalized NL interactions with endothelial cells, we investigated mApoE- and dApoE-NL loading a curcumin-derivative (Re F. et al., 2011) to bind Aβ. We clearly demonstrated that the mApoE-functionalization allows a better drug cellular internalization, whereas dApoE-NL enhances drug PE at the highest extent. We then considered mApoE- and dApoE-NL exposing the Aβ targeting ligands phosphatidic acid (PA) or cardiolipin (CL), demonstrating that PA-mApoE-NL showed the highest cellular uptake and PE. We also studied TAT-NL exposing curcumin derivative3 (Airoldi C. et al., 2011) for Aβ binding, clearly indicating that TAT functionalization increased cellular uptake and PE of curcumin derivative3-NL. We also studied intracellular fate of NL double functionalized, exposing Aβ targeting ligands, and no co-localization was detected with acidic cellular compartments, suggesting that NL may escape from lysosomal degradative pathway. Taken together, these results indicate that the formulations herein analyzed are suitable tools for brain targeted drug and contrast agent delivery. We suggest further development of mApoE and dApoE-NL entrapped with a drug payload for their employment as BBB endothelial cell or brain targeted drug delivery tools, respectively. We also selected PAmApoE-NL and curcumin derivative3-TAT-NL as promising tools for their employment in combination for AD therapy and diagnosis. Further studies, based also on in vivo experiments, are needed to evaluate NL suitability for clinical exploitation. Finally, we inquired the endocytic mechanisms that mediates the entry of NL in the endothelial cells of BBB. We employed RNA interference technique to down-regulate caveolin1 expression. Our preliminary data suggest that caveolin1 and the related caveolaemediated endocytosis pathway may account for 40% of mApoE-NL cellular uptake. Future directions regard the down-regulation of other proteins specifically involved in different endocytic mechanisms, i.e. clathrin-mediated and adsoprptive endocytosis, in order to assess which endocytic mechanisms may account for ApoE and TAT-NL internalization.

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13

Wolfe, Laurie. "Using data from the Idaho Achievement Test as a tool for school improvement /." ProQuest subscription required:, 2005. http://proquest.umi.com/pqdweb?did=1184156701&sid=1&Fmt=2&clientId=8813&RQT=309&VName=PQD.

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14

Nasuf, Gulfem Ipek. "Carbon nanotube growth on tool steel substrates by thermal chemical vapor deposition (CVD) /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1559857141&sid=1&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Thesis (M.S.)--Southern Illinois University Carbondale, 2008.<br>"Department of Mechanical Engineering and Energy Processes." Includes bibliographical references (pages 117-119). Also available online.

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15

Lin, Chi-Ying. "Adaptive and repetitive control of a fast tool servo for precision motion control." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1568414831&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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16

Tadlock, Rebecca Lynn. "One School, Many Differences: An Assessment Tool for School Counselors and Multicultural Counseling." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1796120841&sid=4&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Thesis (M.S.Ed.)--Southern Illinois University Carbondale, 2009.<br>"Department of Educational Psychology and Special Education." Includes bibliographical references (p. 149-168). Also available online.

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17

Bhushan, Sudhanshu. "Uropathogenic Escherichia coli block MyD88 dependent and activate MyD88 independent signaling pathways in rat testicular cells /." Giessen : VVB Laufersweiler, 2008. http://d-nb.info/992792584/04.

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18

Tobin, Derek. "An RCT comparison of advice versus usual care in low back pain patients classified as low risk with the start-back tool." Thesis, Glasgow Caledonian University, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.726788.

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19

Yu, Ning. "A computational tool for the prediction of small non-coding RNA in genome sequences /." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1967802741&sid=7&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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20

Rias, Rishath Ahamed Sheriff. "An open bisimilarity based automated verification tool for pi-calculus family of process calculi /." Available to subscribers only, 2006. http://proquest.umi.com/pqdweb?did=1240708311&sid=8&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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21

Matheron, Michael E., and Martin Porchas. "Efficacy of New Fungicides as Potential Management Tools for Phytophthora Crown and Root Rot on Pepper Plants." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2008. http://hdl.handle.net/10150/215006.

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Phytophthora blight of peppers (Capsicum annuum) is caused by the oomycete pathogen Phytophthora capsici. In Arizona, the root and crown rot phase of the disease initially can appear on plants early in the growing season in areas of the field where soil remains saturated with water after an irrigation or rainfall event. Disease severity can increase dramatically due to summer rains during July and August in the southeastern Arizona production area. Fungicides are an important component of a Phytophthora disease management system, when used in combination with other management practices such as crop rotation, raised beds, and water management. The efficacy of the systemic fungicide mefenoxam (Ridomil Gold) for control of Phytophthora blight on pepper has been documented; however, in many pepper production regions, populations of the pathogen insensitive to this fungicide have developed. Other chemistries, including dimethomorph (Acrobat) as well as some new fungicides in development, have activity on some species of Phytophthora and associated diseases on crops other than pepper. The objective of the following study was to evaluate these additional chemistries for efficacy in suppressing development of root and crown rot on pepper plants grown in soil naturally infested with Phytophthora capsici in a greenhouse environment. The mean duration of survival for Aristotle bell pepper plants in untreated soil infested with P. capsici was 29 days. On the other hand, a significant increase in pepper plant survival was achieved when soil was treated with Reason (fenamidone) + Previcur Flex (propamocarb), SA-110201, Ranman (cyazofamid), Omega (fluazinam), Ridomil Gold (mefenoxam), V-10161(fluopicolide), Forum (dimethomorph), NOA-446510 (mandipropamid), IR-6141 (kiralaxyl), and Maestro (captan). The data from this study suggest that several fungicides currently not registered for use on peppers may be effective components of a management program for Phytophthora crown and root rot. The data is promising; however, additional studies in field soil naturally infested with P. capsici are needed to confirm these preliminary findings as well as to determine the optimal application rate and timing for each new chemistry.

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22

Zukal, Martin. "Sdílení plochy při video a audiokonferencích." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218251.

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The following diploma thesis is devoted to the desktop sharing description and its opportunities. Existing solutions and their advantages and disadvantages are described at the beginning of the text. The most extensive part deals with the design and the implementation of a new solution for the desktop sharing. The thesis aims at providing a possibility to observe desktop of one computer from another one. For achieving it, two appliactions (a server and a client) have been developed, and they are described in the text with utilization of UML (Unified Modeling Language) diagrams. The RFB (Remote Framebuffer) protocol has been chosen as the means for communication between the applications. A detailed description of this protocol is also included in the text. The developed solution is tested and compared with other similar applications in the final part of the work. After that, some areas needing slight improvements are named to achieve competitiveness of the developed solution with other applications of a similar type.

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Friedrich, Jurgen. "Compliance with international law the Kyoto Protocol's compliance mechanisms as an effective tool to promote compliance? /." Montréal : McGill University, 2004. http://proquest.umi.com/pqdweb?did=885683501&sid=1&Fmt=2&clientId=78006&RQT=309&VName=PQD.

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Jiang, Yi. "Design and implementation of tool-chain framework to support OpenMP single source compilation on cell platform." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 83 p, 2008. http://proquest.umi.com/pqdweb?did=1459924771&sid=29&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Bishop, Saundra. "Orchestrating at the piano : orchestration as an interpretive tool for the piano student /." Full text available from ProQuest UM Digital Dissertations, 2009. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1913296571&SrchMode=1&sid=1&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1278699456&clientId=22256.

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Ito, Kouta. "Use of the osteoporosis self-assessment tool : for referring older men for bone densitometry, a decision analysis /." Access full-text from WCMC :, 2008. http://proquest.umi.com/pqdweb?did=1527840081&sid=13&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Sood, Aditya. "Integrated watershed management as an effective tool for sustainable development using distributed hydrological models in policy making /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 190 p, 2009. http://proquest.umi.com/pqdweb?did=1833621281&sid=2&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Elvung, Ellen, and Matilda Petersson. "Digitala verktyg i matematikundervisningen - medel eller mål? : En kvalitativ studie med fokus på hur matematiklärare på gymnasiet använder och motiverar digitala verktyg i undervisningen i samband med digitaliseringen i ämnet." Thesis, Linnéuniversitetet, Institutionen för matematik (MA), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-79679.

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Idén till denna studie uppkom i samband med den förändring i styrdokumenten gällande digitalisering av ämnet Matematik som trädde i kraft 2017. Syftet med studien är att undersöka hur lärare använder och motiverar användandet av digitala verktyg i matematikundervisningen, samt i vilken utsträckning de har förändrat sin undervisning i samband med digitaliseringen av läroplanen. Fem gymnasielärare i matematik deltog i semi-strukturerade intervjuer och fyra matematiklektioner observerades strukturellt. Resultatet visar att lärare använder digitala verktyg både som ett medel för att ge eleverna matematisk kunskap, men också som ett mål för att eleverna ska lära sig de digitala verktygen. Lärarna motiverar användningen av digitala verktyg med att det sparar tid, förenklar representationer av olika koncept, och att de i vissa fall underlättar undervisningen. Lärarna menar också att digitala verktyg kan bidra med att införa nya metoder för lärande, att de förbereder eleverna för nationella prov och för ett liv i det digitala samhället. Lärarna gjorde små eller inga ändringar i sin undervisningspraktik i samband med förändringen i läroplanen, och i de fallet en förändring skedde hade läraren ”öppnat upp” för utökad användning av digitala verktyg.<br>The idea for the study appeared as a result of the change related to the digitalization of the subject Mathematics in the Swedish senior high school that took effect in 2017. The purpose of the study is to investigate how teachers use and motivate the use of digital tools in the Mathematical education, and if and how the teachers say that they have made changes in their teaching due to the curriculum change. Five mathematics teachers working at senior high schools took part in semi-structured interviews and four mathematics classes were observed structurally. The result has been interpreted by using the framework RAT, Curriculum theory and ATD. The result shows that teachers use digital tools both as an equipment to reach the pupils mathematical understanding, but also as a goal for the pupils to learn the tools. The teachers motivate the use of digital tools by saying that it saves time, makes representations of concepts easier to show, and that it in some cases makes the teaching easier. They also say that digital tools can help introduce new ways of learning, that they prepare the pupils for national tests where they must be able to use digital tools, and that they prepare the pupils for a life in the world of digitalization. The teachers did none or a small change to their ways of teaching due to the curriculum change, and in that case, they said that they “opened up” more for the use of digital tools.

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Helley, Martin. "Toll-like receptor expression and signalling in rat trigeminal neurons : consequences for oral infection and mechanisms of orofacial pain." Thesis, University of Plymouth, 2016. http://hdl.handle.net/10026.1/5402.

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The activation of Toll-like receptors (TLRs), expressed by peripheral sensory neurons, represents an innate surveillance function of sensory neurons with important consequences for neuronal function. Despite recent advances, many properties of neuronal TLRs remain poorly understood, particularly within the trigeminal system. The main objectives of this thesis, therefore, were to better characterise the expression and functional consequences of activation of neuronal TLRs in the setting of orofacial pain. A detailed, quantitative description of TLR4, TLR2 and TLR7 expression within neurochemically- identified sub-populations of trigeminal ganglion (TG) sensory neurons suggests that these receptors are primarily expressed by nociceptor sub-populations. Acute activation of these TLRs, in TG neurons, induced an increased gene expression of the pro-inflammatory cytokines, TNF and IL-1 . In an attempt to identify further novel co-modulators of neuronal TLR activation, the expression of lysophosphatidylcholine acyltransferase (LPCAT) isoforms, a phospholipid remodelling enzyme that is known to mediate TLR4 activation in macrophages, are described within TG neurons. Under naïve conditions, LPCAT1 was expressed by a range of sensory neuron sub-types whereas LPCAT2 expression was confined to non-neuronal cells. Following nerve injury, the expression of LPCAT2 was induced in a small proportion of TG neurons in vitro whilst the expression of LPCAT1 remained unaltered. These results may support a role for LPCAT2 in neuronal TLR activation following a priming stimulus, such as nerve injury. Taken together, the results presented in this thesis support the hypothesis that trigeminal nociceptors can directly detect and respond to pathogenic challenge and tissue damage. The acute activation of TLRs, expressed by trigeminal nociceptors, results in the up-regulation of pro-inflammatory cytokines which are known to activate and sensitise neurons. The activation of neuronal TLRs may therefore contribute to the increased neuronal excitability and pain that accompanies common orofacial disorders.

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Zhu, Tingting. "A depth-averaged two-dimensional water quality model as a research and management tool /." Full text available from ProQuest UM Digital Dissertations, 2006. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1394652381&SrchMode=2&sid=3&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1216841482&clientId=22256.

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Downes, Dawn M. "Designing evaluation tools for the Differentiated Instruction Staff Development Initiative." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 264 p, 2007. http://proquest.umi.com/pqdweb?did=1253510301&sid=2&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Bradonjić, Milan. "Models and tools for large graphs with imposed structural properties." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1750724071&sid=2&Fmt=2&clientId=48051&RQT=309&VName=PQD.

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Ferraro, Joseph Vincent. "Broken bones and shattered stones on the foraging ecology of Oldowan hominins /." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1568044151&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Mansouri, Saara. "Developing novel molecular tools to study the Fusarium virguliforme-soybean interaction /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1324370161&sid=4&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Thesis (M.S.)--Southern Illinois University Carbondale, 2007.<br>"Department of Plant, Soil Science and Agricultural Systems." Includes bibliographical references (leaves 70-77). Also available online.

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Eshete, Getachew. "Assessment of fuelwood resources in acacia woodlands in the Rift Valley of Ethiopia : towards the development of planning tools for sustainable management /." Umeå : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5638-X.pdf.

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Fluegel, Amanda M. "Validation of diagnostic assays and development of molecular epidemiological tools for brucellosis." Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1594477821&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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Li, Ying. "Too Many Theories Or Too Many Skills? The Perceived Impact Of Theoretical Knowledge Of Mass Communication Among Journalists And Public Relations Practitioners." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1878966091&sid=13&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Thesis (Ph. D.)--Southern Illinois University Carbondale, 2009.<br>"College of Mass Communication and Media Arts." Keywords: Journalism, Journalism education, Journalist, Mass communication theory, Public relations, Public relations practitioner. Includes bibliographical references (p. 161-188). Also available online.

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Chen, Yuan. "A performance evaluation methodology for pi-Calculus family of multi-process modeling tools /." Available to subscribers only, 2006. http://proquest.umi.com/pqdweb?did=1203587971&sid=19&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Shepherd, David. "Natural language program analysis combining natural language processing with program analysis to improve software maintenance tools /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 176 p, 2007. http://proquest.umi.com/pqdweb?did=1397920371&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Pham, Long Ba. "Comparison of non-invasive screening tools to assess adolescents who are "at risk" for Type 2 Diabetes /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1597629431&sid=3&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Pelletreau, Karen Nicole. "The application of molecular tools towards the study of brown algal chemical ecology and the production of phlorotannins." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 230 p, 2008. http://proquest.umi.com/pqdweb?did=1601234901&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Welford, Gabrielle. "Too many deaths decolonizing Western academic research on indigenous cultures /." Thesis, University of Hawaii at Manoa, 2003. http://proquest.umi.com/pqdweb?index=0&did=765883251&SrchMode=1&sid=6&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1208476968&clientId=23440.

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Delany, Caroline. "An investigation into the role of mGlu5 receptors in depotentiation in area CA1 of adult rat and mouse hippocampus and the kainate GluR5 receptor antagonist, LY382884 : pharmacological profile and use as a tool to study the functional role of kainate rece." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271848.

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Potter, Jamie L. "Identifying the cytokine response and toll-like receptor expression in genital epithelial cell co-infection by herpes simplex virus and chlamydia trachomatis /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1594496161&sid=8&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Thesis (Ph. D.)--Southern Illinois University Carbondale, 2008.<br>"Department of Molecular Biology, Microbiology and Biochemistry." Includes bibliographical references (p. 110-131). Also available online.

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Mukherjee, Prasenjit. "Use of molecular modeling tools in the elucidation of ligand-macromolecular interactions and applications in structure-based drug design /." Full text available from ProQuest UM Digital Dissertations, 2008. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1850501401&SrchMode=1&sid=4&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1277323802&clientId=22256.

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Thesis (Ph.D.)--University of Mississippi, 2008.<br>Typescript. Vita. Major professor: Mitchell A. Avery Includes bibliographical references (leaves 246-259). Also available online via ProQuest to authorized users.

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Hyde, Luke Justin. "Improvements in machine tools with respect to vibration damping : a dissertation presented to the faculty of the Graduate School, Tennessee Technological University /." Click to access online version, 2007. http://proquest.umi.com/pqdweb?index=74&did=1445048001&SrchMode=1&sid=1&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1255027505&clientId=28564.

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Allwell-Brown, Gbemisola. "Individual and household-level determinants of malaria infection in under-5 children from north-west and southern Nigeria : A cross-sectional comparative study based on the 2015 Nigeria Malaria Indicator Survey." Thesis, Uppsala universitet, Internationell mödra- och barnhälsovård (IMCH), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-324360.

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Introduction Nigeria has the highest malaria burden worldwide. The 2010 and 2015 Nigeria Malaria Indicator Surveys (NMIS) suggest an improvement in malaria indicators, with the North West zone lagging behind. This study aimed to identify the individual and household-level malaria determinants in north-west and southern Nigeria, using Rapid Diagnostic Testing (RDT) and microscopy for malaria diagnosis. Methods Data on 3,358 children aged 6-59 months from north-west and southern Nigeria from the 2015 NMIS was used. The two populations were compared using chi-square tests, and logistic regression analysis was done for determinants of malaria infection, based on RDT and microscopic malaria test results. Results Malaria prevalence by RDT in the north-west and south was 55.8% and 29.2%, respectively (37.0% and 14.9%, respectively by microscopy). In both populations, a higher age, positive RDT in an additional household member and rural residence increased the odds of malaria infection; while higher education of the head of household and greater household wealth lowered the odds of malaria infection. Household clustering of RDT-positive cases appeared to be stronger in the south compared to the north-west. There were no statistically significant differences between the results using RDT or microscopy. Conclusion Irrespective of the diagnostic tool used, malaria determinants were similar in north-west and southern Nigeria. However, poorer social circumstances were observed in the north-west, and may account for the delayed progress in malaria control in the region. There may be a need to intensify malaria control efforts, particularly in the north-west, while awaiting socio-economic development.

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Karnes, Jesse Deneen. ""It's our country too!" Palestinian identity and the Islamic claim to human righs in the Hashemite Kingdom of Jordan /." Diss., UC access only, 2009. http://proquest.umi.com/pqdweb?index=90&did=1887560071&SrchMode=1&sid=1&Fmt=7&retrieveGroup=0&VType=PQD&VInst=PROD&RQT=309&VName=PQD&TS=1270249121&clientId=48051.

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Thesis (Ph. D.)--University of California, Riverside, 2009.<br>Includes abstract. Includes bibliographical references (leaves 270-285). Issued in print and online. Available via ProQuest Digital Dissertations.

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Peixoto, Leonardo Gomes. "Análise do papel da metformina na via insulínica, não-insulínica e inflamatória." Universidade Federal de Uberlândia, 2015. https://repositorio.ufu.br/handle/123456789/15755.

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Fundação de Amparo a Pesquisa do Estado de Minas Gerais<br>Doutor em Genética e Bioquímica<br>CHAPTER II: Purpose: We performed a meta-analysis of randomized trials to assess the effect of metformin on inflammatory markers and metabolic parameters in subjects with diabetes. Methods: We performed comprehensive searches on NCBI, Cochrane, Science Direct databases from 1966 to Jun of 2015. We included randomized trials of at least 4 weeks duration that compared groups with diabetes before and after the treatment with metformin or metformin plus other drugs, and evaluated body mass index, blood glucose, HbA1c and inflammatory parameters such as C-reactive protein, tumor necrosis factor and adiponectin. Results: Pooled results of the 26 trials, with 1760 participants at the end of treatment reduce BMI in 0.9% p=0,0043, as well as, decrease of blood glucose level [SMD -0,411 mg/dL, 95%CI -0,463 to -0,369, I2= 56.62%], HbA1c [SMD -0.479%, 95%CI -0,568 to -0,390, I2= 55.02%], CRP levels [SMD -0,274mg/dL, 95%CI -0,419 to -0,129, I2= 72.78%], TNFα concentration [SMD -0,103pg/ml, 95%CI -0,514 to 0,309, I2= 87.67%] and increase of adiponectin [SMD 0,171μg/ml, 95%CI 0,098 to 0,440, I2= 81.09%] compared with pretreatment. Conclusion: The long-treatment with metformin monotherapy or metformin plus other drugs improves metabolic parameters and induced changes in inflammatory markers in diabetic subject. CHAPTER III: Background: Metformin increases insulin sensitivity by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle. However, modulation of inflammatory response and CaMKKβ/AMPK/Myosin V activation in gastrocnemius muscle by metformin treatment has not been demonstrated in hypoinsulinemic diabetic rats. Objective: The present study investigated how the metformin improve insulin sensitivity in skeletal muscle of hypoinsulinemic diabetic rats. Methods: Diabetes was induced by streptozotocin (45 mg/kg, intraperitoneally) 10 days prior treatments. On 11th day, diabetic rats were treated with metformin (500 mg/kg, oral gavage), insulin (2U at 08:00 h and 4U at 17:00 h, subcutaneously) or untreated. After 20 days, glycemia was measured and insulin sensitivity was determined by KITT. Serum Insulin, GLUT4, IRSthr, inflammatory markers (NF-κB, IκB, TNF-α and p-JNK) and CAMKK, AMPK and Myosin V in gastrocnemius muscle were determined by ELISA. Results: As expected, insulin and metformin improved the insulin sensitivity. Besides, metformin treatment promoted reduction in inflammatory response mediated by NF-κB, IκB, TNF-α and p-JNK, and that was accompanied by increased CaMKKβ/AMPK/Myosin V/GLUT4 pathway activity in gastrocnemius muscle of diabetic rats. Conclusion: Our findings suggest that metformin induces significant reductions in several inflammatory markers in skeletal muscle of diabetic rats. Metformin-induced increase in CaMKKβ/AMPK/Myosin V/GLUT4 pathway activity was associated with higher insulin sensitivity. CHAPTER IV: Diabetes is characterized by a proinflammatory state which can activate TLR2 and TLR4, and these receptors could induce NF-κB and JNK activation in skeletal muscle. In this study, we investigated the inflammatory and apoptotic signaling pathways triggered by TLRs/NF-κB and JNK activation in skeletal muscle of diabetic rats treated with metformin before and after an insulin tolerance test. Metformin treatment decreased p-JNK and NF-κB, and increased IκB concentrations. This attenuation leads to a decrease of TNFα and CXCL1/KC, and an increase of p-AMPK, BAX and Bcl2 concentration. Furthermore, KITT revealed an improvement of the insulin sensitivity in the diabetic rats treated with metformin. In addition, metformin was not capable of attenuating the changes in the inflammatory pathway triggered by insulin injection as the increase of TNFα and TLR4 in metformin treated rats, and IκB, CXCL1/KC, TNFα and p-AMPK increase in the untreated group. Taken together, these results point out that metformin may attenuate the activation of the inflammatory pathway TLRs/NF-κB/TNFα/CXCL1/KC and the apoptotic signaling BAX/Bcl2/p-JNK, which could be accompanied by a reduction of the inflammatory damage caused by hyperglycemia and an improvement of insulin sensitivity in diabetic rats.

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Ameer, Muhammad. "Integrated and multi-criteria approaches for process plan generation in reconfigurable manufacturing systems with consideration of system capabilities and product constraints." Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0242.

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Les systèmes de fabrication modernes connaissent un changement de paradigme qui met l'accent sur l'intégration des technologies du numérique dans les systèmes de production afin de relever le défi des demandes incertaines du marché. Les systèmes de fabrication ont besoin d'une certaine réactivité pour faire face à ces incertitudes en s'adaptant en conséquence, et nécessitent une plus grande évolutivité aux niveaux physique et logique. À cet effet, les systèmes de fabrication modernes sont conçus avec des capacités de ressources dynamiques, avec des composants modulaires, de sorte qu'ils puissent fournir le niveau requis de reconfigurabilité. Dans la perspective de l'"industrie 4.0", la reconfigurabilité est indispensable à l'adaptation efficace des systèmes de fabrication dans un environnement complexe. La reconfigurabilité permet une adaptation rapide de ces systèmes ainsi qu'une réactivité rapide à la compétitivité socio-techno-économique. L'objectif est de répondre aux défis modernes (externes et internes), c'est-à-dire la personnalisation de masse, la mondialisation, la gestion de la variété des produits, la gestion de la reconfiguration des systèmes et la réduction des délais.Dans cette thèse, le problème de conception des systèmes de fabrication reconfigurables (RMS) est considéré pour répondre aux exigences susmentionnées. L'objectif est de concevoir un système réactif basé sur deux caractéristiques clés : la modularité et la reconfigurabilité. Nous étudions le problème de conception du RMS comme étant le développement d'une gamme de fabrication pour une pièce spécifique de la famille considérée, ainsi que la sélection des capacités de ressources dynamiques du système pour fabriquer cette pièce.Ce travail est divisé en trois parties : (1) Cogénération du processus et du plan de préparation pour une pièce dans un environnement reconfigurable. L'objectif principal est de développer une nouvelle approche pour considérer conjointement les contraintes de préparation et de gamme de fabrication, en tenant compte des relations entre les opérations. (2) Minimisation de l'effort de reconfiguration dans la conception des gammes. Nous proposons un nouvel indice de performance de l'effort généré par la reconfiguration des machines et des fixations, ainsi que le transfert des pièces. L'objectif est d'assurer une meilleure réactivité et une haute performance la gamme conçue. (3) Maximisation de l'utilisation des capacités des ressources dynamiques de la conception RMS. Nous considérons un problème de conception RMS pour la sélection de machines, où la sélection de différents types de machines-outils reconfigurables (RMT) est réalisée pour exécuter la gamme de la pièce considérée<br>Modern manufacturing systems are going through a paradigm shift where the focus is on the integrating the digital technologies in the production systems to address the challenge of uncertain market demands. Manufacturing systems needs certain amount responsiveness to address these uncertainties by adapting accordingly, and require more changeability at physical as well as logical levels. For this purpose, modern-day manufacturing systems are designed with dynamic resource capabilities, with modular components, so that they can provide the required amount of reconfigurability. From the perspective of "industry 4.0", reconfigurability is vital for the effective adaptation of manufacturing systems in a complex environment. Reconfigurability provides the quick adaptation of these systems along with quick responsiveness towards socio-techno-economic competitiveness. The objective is to respond to modern-day challenges (both external and internal), i.e. mass customization, globalization, product variety management, system reconfiguration management, and reducing the lead time.In this thesis, the design problem of reconfigurable manufacturing systems (RMS) is considered which meets the aforementioned requirements. The goal is to design a responsive system based on two key features modularity and reconfigurability. We study the RMS design problem as, the development of a process plan for a particular part of the part family along with the selection of the system's dynamic resource capabilities to perform that part. This work is divided into three parts: (1) Co-generation of process and setup plan for a part in the reconfigurable environment. The main objective is to develop a new approach to jointly consider the setup and process plan constraints, with consideration of relationships between the operations. (2) Minimisation of reconfiguration effort in process design. We propose a novel performance index of the effort generated by the machines and fixtures reconfiguration, and part transfer. The objective is to ensure better responsiveness and high performance of the designed process plan. (3) Maximisation the utilization of dynamic resource capabilities of RMS design. We consider a RMS design problem for machine selection, where selection of different types of reconfigurable machine tools (RMTs) are carried out for performing the process plan of considered part

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