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Dissertations / Theses on the topic 'RGD motif'

Author: Grafiati

Published: 24 April 2022

Last updated: 18 July 2025

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1

Carpentier, Emilie. "EP1 et PME1 : deux protéines pariétales à motif RGD, quels rôles chez le lin ?" Rouen, 2005. http://www.theses.fr/2005ROUES025.

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Chez les animaux, l'adhérence cellulaire dépend d'interactions intégrines/protéines de matrice extracellulaire via un motif RGD. Chez les plantes, les mécanismes d'adhérence sont méconnus, bien que certaines protéines possèdent le motif RGD. Nous avons caractérisé 2 protéines pariétales de lin possédant ce motif. La première, une pectine méthylestérase (PME), catalyse la dé-méthylation des pectines. PME1 est maturée au cours de sa sécrétion et une fois mise en place dans la paroi de cals la surexprimant. Son pro-peptide n'a pas d'impact sur sa localisation. La seconde, EP1, glycoprotéine homol

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2

Chen, Ping. "Etude structure-fonction de la sous-unité beta3 dans le processus d'activation et de fixation du ligand de l'integrine alphaIIbbeta3." Paris 7, 2001. http://www.theses.fr/2001PA077066.

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3

Bourguet, Erika. "Synthèse de mimétiques non-peptidiques du motif RGD (Arg-Gly-Asp) via la chimie des oxaziridines." Montpellier 2, 2000. http://www.theses.fr/2000MON20022.

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4

Pallu, Stéphane. "Rôle d'un peptide à motif RGD cyclique dans la signalisation ostéoblastique : applications aux biomatériaux de comblement osseux." Bordeaux 2, 2004. http://www.theses.fr/2004BOR21182.

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L'ostéoconduction d'un matériau de substitution osseuse peut être améliorée par des modifications de surfaces dont la fonctionnalisation par ligands adhésifs. Nos travaux antérieurs ont permis de sélectionner un peptide RGD cyclique spécifique des intégrines alpha vβ3-alpha vβ5, capable de stimuler l'adhésion des cellules HOP. Le but du travail était de définir les mécanismes susceptibles d'améliorer adhésion et différenciation et quelles étaient les voies de signalisation sollicitées. Nous avons démontré l'implication de p125FAK et des MAPKs p38 et JNK1/2 dans la modulation de l'activation du

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5

Chaleix, Vincent. "Synthèse et caractérisation de nouvelles porphyrines glucolysées peptidiques à motif RGD en vue de leur application en photothérapie dynamique." Limoges, 2003. http://aurore.unilim.fr/theses/nxfile/default/5087682f-d38e-4c8b-b7f0-076ca0d07983/blobholder:0/2003LIMO0047.pdf.

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Certaines porphyrines et analogues sont utilisés comme photosensibilisateurs en photothérapie dynamique des cancers. Les porphyrines glucosylées sont, dans ce domaine particulièrement intéressantes. En outre, il est connu que les cellules endothéliales constitutives de la néovascularisation tumorale, ainsi que certaines cellules cancéreuses, surexpriment l'intégrine aVb3. Cette glycoprotéine transmembranaire est capable de se lier aux protéines de la matrice extracellulaire par l'intermédiaire de la séquence peptidique Arginine-Glycine-Acide Aspartique (RGD). Avec pour finalité leur applicatio

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6

Amar, Kshitij. "AN ANALYSIS OF RGD CELL ADHESION MOTIF USING QUARTZ CRYSTAL MICROBALANCE TO UNDERSTAND THE LOADING RATE OF CELL LIGAND INTERACTION." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/theses/2202.

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It is now well accepted that mechanical environment partly defines the cellular behavior. The understanding of cell interactions with mechanical microenvironment is the most crucial step to control cell functions in disease and development. Living cells utilize cell surface receptors to interact with the ligands present in mechanical environments. Over the last few decades, several dominant techniques such as AFM, optical tweezers, magnetic tweezers, biomembranes force probes etc. have been extensively used to characterize the ligand-receptor interactions at the molecular level. These studies

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7

Schmidt, Julien. "Nouveaux motifs peptidiques de reconnaissance des néo-vaisseaux : synthèse et évaluation pour le diagnostic et la thérapie des cancers." Montpellier 2, 2008. http://www.theses.fr/2008MON20218.

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Pour se développer une tumeur doit se constituer un réseau de vaisseaux sanguins capables d'apporter des nutriments et de l'oxygène, c'est ce que l'on appelle la néo-angiogénèse. Agir sur la néo-angiogenèse tumorale constitue une stratégie de choix pour limiter le développement de la tumeur et prévenir la formation de métastases. Les néo-vaisseaux tumoraux sur-expriment l'intégrine αVβ3, présente également sur de nombreuses lignées tumorales humaines. Ce récepteur constitue une cible majeure pour des agents anti-angiogéniques. Comme plus de la moitié des récepteurs de la famille intégrine, αVβ

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8

Jacob, Dietmar [Verfasser]. "GENTHERAPIE DURCH EINEN RGD-MOTIV MODIFIZIERTEN, HUMANEN TELOMERASE REVERSE TRANSKRIPTASE REGULIERTEN, TUMOR NEKROSE FAKTOR VERWANDTEN APOPTOSE INDUZIERENDEN LIGAND EXPRIMIERENDEN ADENOVIRALEN VEKTOR / Dietmar Jacob." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1022871218/34.

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9

Vella, Fanny. "Conception de vecteurs protéiques spécifiques des intégrines : le module EGF comme support de motifs RGD et son utilisation pour le ciblage cellulaire d'une activité biologique." Université Joseph Fourier (Grenoble), 2002. http://www.theses.fr/2002GRE10193.

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10

Guarnaccia, Corrado. "Interaction of RGG and HTH motifs with nucleic acids : a study with rationally designed synthetic and recombinant polypeptides." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368806.

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11

Salheiser, Britta. "Conflicting stories of war zur Polyphonie narrativer Repräsentationsformen in Stephen Cranes The Red Badge of Courage." Trier Wiss. Verl. Trier, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2850761&prov=M&dok_var=1&dok_ext=htm.

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12

Söldner, Magdalene. "Bios eudaimon : zur Ikonographie des Menschen in der rotfigurigen Vasenmalerei Unteritaliens : die Bilder aus Lukanien." [Möhnesee] Bibliopolis, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&docl̲ibrary=BVB01&docn̲umber=015671623&linen̲umber=0002&funcc̲ode=DBR̲ECORDS&servicet̲ype=MEDIA.

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13

Zardini, Francesca. "The myth of Herakles and Kyknos : a study in Greek vase-painting and literature /." Verona : Fiorini, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?u20=9788887082937.

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14

Scapin, Mathieu. "Les premiers ateliers à figures rouges en Italie du sud (440-375 av. J.-C.)." Thesis, Toulouse 2, 2016. http://www.theses.fr/2016TOU20126.

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Les premiers peintres des vases à figures rouges ont été classés par A.D. Trendall entre 1938 et 1989. Ses recherches, associées à ceux des historiens et archéologues, constituent un remarquable outil d’analyse pour les historiens de l’art. Elles permettent d’appréhender d’un seul coup d’œil le corpus de vases italiotes collectés auprès des collections privées ou des musées. A la manière de J. BEAZLEY pour les vases attiques, A.D. TRENDALL s’est attaché à attribuer des vases anonymes et sans provenance à des peintres qu’il a lui–même nommé. Néanmoins, depuis plusieurs années, ses classements s

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15

Yu, Jung-Chuan, and 余蓉荃. "Artificial Extracellular Matrix Proteins Containing Glycosaminoglycan-binding Domain and RGD Motif." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/49061587150294331583.

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碩士<br>國立清華大學<br>生物科技研究所<br>93<br>The extracellular matrix (ECM) influences the survival, development, migration, proliferation, shape, and function of the cells that contact it. Through the design and expression of artificial genes, it is possible to prepare artificial ECM (aECM) proteins with domains chosen to modulate cellular behaviors. The objective of this study was to examine what combination of the RGD-containing fragments with two JEV E protein heparin-binding domains, served as aECM proteins, were suitable materials for human osteoblast-like MG-63 cells and human articular chondrocy

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16

Yi-ChunChen and 陳怡均. "The role of the RGD motif and C-terminus of Echistatin and Rhodostomin in recognition of integrins." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/30342825277800639484.

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博士<br>國立成功大學<br>基礎醫學研究所<br>100<br>Integrins are α/β heterodimeric cell surface receptor and are involved in cell proliferation, migration and cell survival. Because they contribute to the initiation and progression of many common diseases, such as thrombosis, immune system disorders, cancer, and osteoporosis, they are attractive therapeutic targets for many diseases. Disintegrins are potent integrin inhibitors found from snake venoms. According to the size and the number of disulfide bonds, they can be classified into small, medium, long, and dimeric disintegrins. To study structure, dynamics,

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17

Hsieh, Yao-Hsun, and 謝堯勳. "The Roles of the RGD Motif and C-Terminal Region of Disintegrin in Recognizing Integrins avb3 and a5b1." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/75499578157318090460.

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碩士<br>國立成功大學<br>生物化學研究所<br>94<br>Integrins are a/b heterodimeric receptors that are involved in cell adhesion, mobility, and signal transduction. Many physiological and non-physiological integrin ligands utilize RGD, LDV, or a short sequence as a key structural component for their integrin-binding site. Disintegrins are a family of RGD-containing and cysteine-rich proteins isolated from snake venoms. They interact with the b1 and b3 families of integrins. Rhodostomin (Rho) is a disintegrin that inhibits the platelet aggregation by blocking integrin aIIbb3 of platelets. Rho consists of 68 amino

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18

Storey, Pamela A. "The role of a second RGD motif in the ID protein of a Namibian SATI foot-and-mouth disease virus for target cell attachment." Diss., 2005. http://hdl.handle.net/2263/27875.

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Foot-and-mouth disease virus (FMDV), which is a member of the Aphthovirus genus of Picornaviridae, is an economically important animal virus that infects cloven-hoofed animals. At least two families of cell-surface receptors have been identified that mediate binding of FMDV to susceptible cells, i.e. integrins and heparan sulfate proteoglycans (HSPG). Whereas several tissue culture-adapted FMD viruses use heparan sulfate proteoglycans for internalization, field isolates of FMDV use integrins as receptors. A conserved amino acid sequence Arg-Gly-Asp (RGD), located in the surface-exposed flexibl

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19

Bhatter, Nupur. "Understanding mRNA fate regulation by RGG motif protein, Sbp1." Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5549.

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Cellular events that rely on translation regulation has been well established, however the molecular details of factors involved in bringing translation control remains inadequately explored. RNA binding proteins form an integral part of transcriptional and post-transcriptional gene regulation pathway. However, the principles that govern the activity of an RNA binding protein is poorly explored. In this thesis, a systematic investigation has been done to delineate the contribution of individual RRM domains and arginine methylation in the RGG motif of an RNA binding protein, Sbp1 to

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20

Poornima, G. "Understanding the Regulation of mRNA Translation Repression by RGG-motif Proteins." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/4560.

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Messenger RNA translation is one of the most energy expensive steps in the process of gene expression and therefore translation regulation is critical for maintaining cellular homeostasis. In contrast to transcriptional regulation, rapid cellular changes in protein levels and thus physiological homeostasis can be achieved by regulation of mRNAs at translation level. At every stage of its life cycle, mRNA associates with RNA-binding proteins. The dynamic remodeling of mRNPs plays a major role in translation control and deciding mRNA fate. In yeast, a conserved translation initiation factor eIF4

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21

Gole, Shirish Gajanan. "Understanding the Role of Lsm Domain in Translation Repression Activity of RGG-motif Containing Protein Scd6." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4286.

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Control of gene expression in eukaryotes is regulated at various steps such as transcription, translation and protein degradation. Translation repression of mRNA regulates protein levels and maintains cell homeostasis. Translation control allows for spatiotemporal regulation of gene expression which is required for development and differentiation in organisms. Deregulation of translation can result in disease conditions like cancer and neurodegenerative diseases. In yeast Saccharomyces cerevisiae, the RGG-motif protein Scd6 (Suppressor of Clathrin Deficiency 6) represses translation by binding

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22

Corley, Susan M. "Potential RNA binding functions for Shadoo through identification and characterisation of an RGG box motif." Phd thesis, 2010. http://hdl.handle.net/1885/149638.

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Shadoo (Sho) is a member of the prion protein (PrP) family, found mainly in the brain. PrP is well-known as the central agent involved in the prion diseases - a form of fatal neurodegenerative disease. Despite decades of intense research, the natural functions of PrP have not been clearly elucidated. The reasons for this are complex, but it is likely that there is a level of redundancy in the functions performed by PrP. In particular, it has been suggested that Sho may have overlapping functions with PrP and that both proteins can compensate for one another. Therefore, investigating the natura

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23

Ničová, Eva. "Funkce proteinu Slu7 v sestřihu pre-mRNA Saccharomyces cerevisiae." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-307799.

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Alternative splicing is one of the mechanisms how to regulate gene expression. Under different conditions, different mRNAs encoding proteins with different function, localization or stability can be made from one cellular transcript. The human hSlu7 protein affects the alternative splicing of some genes through alternative 3'splice site (3'SS) selection. Although it was thought that alternative splicing is absent from Saccharomyces cerevisiae, recent results argue against such conclusion. We therefore decided to characterize the function of the yeast Slu7 protein, which participates in the sec

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24

Wu, Chia-Wei, and 吳家維. "Physical association between EBV protein EBNA-1 and P32/TAP/hyaluronectin-interaction through "RGG" RNA binding motifs of EBNA-1." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/94931810097654324186.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>86<br>EBNA-1在EB病毒潛伏感染的細胞內，以雙分子形式結合在特定的DNA序列上，促使潛伏期 EB病毒DNA的複製、調控潛伏期基因的表現，並維持EB病毒以質體形式穩定存在於細胞內。EBNA-1同時是唯一在各種EB病毒相關腫瘤中都會表現的潛伏蛋白質。我們已經在EBNA-1 轉染的293細胞中利用免疫沉澱法找到一個細胞內蛋白質P32與EBNA-1共同免疫沉澱下來，本論文更定位出EBNA-1是以胺基酸1-102, 325-498的區域與P32蛋白質結合。同時我們也發現P32蛋白質會被一個辨識TAP (HIV Tat-associated protein)的抗血清所辨認。此外P 32/TAP也被證實會與其它RNA結合蛋白如HIV Rev及細胞內剪接因子SF2結合，暗示P32/TAP 參與RNA剪接或細胞核內到外運送等機制的可能性。除此之外P32/TAP還被證實是聚玻璃糖酸(hyaluronic acid, HA)及補體C1q globular ''''head''''的接受器，因此P3

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25

Wu, Jia-Wei, and 吳家維. "Physical association between EBV protein EBNA-1 and P32/TAP/hyaluronectin-interaction through ""RGG""RNA binding motifs of EBNA-1." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/90467165535787976375.

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26

Roy, Raju. "Exploring the role of low complexity protein sequence in regulating RNA granule dynamics and translation control." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5975.

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RNA granules are conserved membraneless mRNP complexes that play an important role in determining mRNA fate by affecting translation repression and mRNA decay. Processing bodies (P-bodies) harbor enzymes responsible for mRNA decay and proteins involved in modulating translation. Although many proteins have been identified to play a role in P-body assembly, a bonafide disassembly factor remains unknown. We observed that Sbp1 with the help of its RGG-motif promotes P-body disassembly in S. cerevisiae. This study provides an example of the role of low complexity sequence in RNA granule di

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