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Journal articles on the topic 'RGNNV'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Lei, Yingying, Yu Xiong, Dagang Tao, et al. "Construction of Attenuated Strains for Red-Spotted Grouper Nervous Necrosis Virus (RGNNV) via Reverse Genetic System." Viruses 14, no. 8 (2022): 1737. http://dx.doi.org/10.3390/v14081737.

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The nervous necrosis virus (NNV) mainly attacks the central nervous system of fish to cause viral nervous necrosis, which is an acute and serious prevalent disease in fish. Among different genotypes of NNV, red-spotted grouper nervous necrosis virus (RGNNV) is the most widely reported, with the highest number of susceptible species. To better understand the pathogenicity of RGNNV, we first developed a reverse genetic system for recombinant RGNNV rescue using B7GG and striped snakehead (SSN-1) cells. Furthermore, we constructed attenuated RGNNV strains rRGNNV-B2-M1 and rRGNNV-B2-M2 with the los

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2

García-Álvarez, Miguel Ángel, Marta Arizcun, Elena Chaves-Pozo, and Alberto Cuesta. "Profile of Innate Immunity in Gilthead Seabream Larvae Reflects Mortality upon Betanodavirus Reassortant Infection and Replication." International Journal of Molecular Sciences 23, no. 9 (2022): 5092. http://dx.doi.org/10.3390/ijms23095092.

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Historically, gilthead seabream (Sparus aurata) has been considered a fish species resistant to nervous necrosis virus (NNV) disease. Nevertheless, mortality in seabream hatcheries, associated with typical clinical signs of the viral encephalopathy and retinopathy (VER) disease has been confirmed to be caused by RGNNV/SJNNV reassortants. Because of this, seabream larvae at 37 and 86 days post-hatching (dph) were infected by immersion with RGNNV/SJNNV and SJNNV/RGNNV reassortants under laboratory conditions, and mortality, viral replication and immunity were evaluated. Our results show that gil

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3

Errani, Francesca, Enrico Volpe, Enrique Riera-Ferrer, et al. "Development and diagnostic validation of a one-step multiplex RT-PCR assay as a rapid method to detect and identify Nervous Necrosis Virus (NNV) and its variants circulating in the Mediterranean." PLOS ONE 17, no. 8 (2022): e0273802. http://dx.doi.org/10.1371/journal.pone.0273802.

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Nervous Necrosis Virus (NNV) represents one of the most threatening pathogens for Mediterranean aquaculture. Several NNV strains are currently co-circulating in the Mediterranean Basin with a high prevalence of the RGNNV genotype and the RGNNV/SJNNV reassortant strain and a more limited diffusion of the SJNNV genotype and the SJNNV/RGNNV reassortant. In the present study, a one-step multiplex RT-PCR (mRT-PCR) assay was developed as an easy, cost-effective and rapid diagnostic technique to detect RGNNV and the reassortant RGNNV/SJNNV strain and to distinguish them from SJNNV and the reassortant

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4

Biasini, Lorena, Paola Berto, Miriam Abbadi, et al. "Pathogenicity of Different Betanodavirus RGNNV/SJNNV Reassortant Strains in European Sea Bass." Pathogens 11, no. 4 (2022): 458. http://dx.doi.org/10.3390/pathogens11040458.

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European sea bass (Dicentrarchus labrax) is an important farmed marine species for Mediterranean aquaculture. Outbreaks of betanodavirus represent one of the main infectious threats for this species. The red-spotted grouper nervous necrosis virus genotype (RGNNV) is the most widely spread in Southern Europe, while the striped jack nervous necrosis virus genotype (SJNNV) has been rarely detected. The existence of natural reassortants between these genotypes has been demonstrated, the RGNNV/SJNNV strain being the most common. This study aimed to evaluate the pathogenicity of different RGNNV/SJNN

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5

Wu, Siting, Mengshi Sun, Xin Zhang, et al. "Grouper TRAF4, a Novel, CP-Interacting Protein That Promotes Red-Spotted Grouper Nervous Necrosis Virus Replication." International Journal of Molecular Sciences 22, no. 11 (2021): 6136. http://dx.doi.org/10.3390/ijms22116136.

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Tumor necrosis factor receptor-associated factors (TRAFs) play important roles in the biological processes of immune regulation, the inflammatory response, and apoptosis. TRAF4 belongs to the TRAF family and plays a major role in many biological processes. Compared with other TRAF proteins, the functions of TRAF4 in teleosts have been largely unknown. In the present study, the TRAF4 homologue (EcTRAF4) of the orange-spotted grouper was characterized. EcTRAF4 consisted of 1413 bp encoding a 471-amino-acid protein, and the predicted molecular mass was 54.27 kDa. EcTRAF4 shares 99.79% of its iden

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6

Gémez-Mata, Juan, Sandra Souto, Isabel Bandín, et al. "Immune Response of Senegalese Sole against Betanodavirus Mutants with Modified Virulence." Pathogens 10, no. 11 (2021): 1388. http://dx.doi.org/10.3390/pathogens10111388.

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Nervous necrosis virus (NNV), genus Betanodavirus, the etiological agent of the viral encephalopathy and retinopathy (VER), presents a genome with two positive-sense single-stranded RNA segments. Striped jack nervous necrosis virus (SJNNV) and red-spotted grouper nervous necrosis virus (RGNNV), together with reassortants RGNNV/SJNNV, are the betanodaviruses predominantly isolated in Southern Europe. An RGNNV/SJNNV reassortant isolated from Senegalese sole (wt160) causes high mortalities in this fish species. This virus presents differences in the sequence of the 3’ non-coding region (NCR) of b

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7

Valero, Yulema, Carmen López-Vázquez, Sandra Souto, José G. Olveira, Alberto Cuesta, and Isabel Bandín. "Differential Nervous Necrosis Virus (NNV) Replication in Five Putative Susceptible Cell Lines." Pathogens 10, no. 12 (2021): 1565. http://dx.doi.org/10.3390/pathogens10121565.

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Viral encephalopathy and retinopathy caused by nervous necrosis virus (NNV), is one of the most threatening viral diseases affecting marine fish worldwide. In vitro propagation of NNV strains is essential for the design of effective control measures. In the present study we analysed both the susceptibility and the permissiveness of five fish cell lines (E-11, GF-1, SAF-1, DLB-1, and SaB-1) to three NNV strains (one RGNNV, one SJNNV, and one reassortant RGNNV/SJNNV). E-11 and DLB-1 were demonstrated to be highly susceptible to NNV strains, with average adsorption efficiency (AE) values higher t

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8

Johnstone, Carolina, Montse Pérez, Marta Arizcun, Cristina García-Ruiz, and Elena Chaves-Pozo. "Reservoirs of Red-Spotted Grouper Nervous Necrosis Virus (RGNNV) in Squid and Shrimp Species of Northern Alboran Sea." Viruses 14, no. 2 (2022): 328. http://dx.doi.org/10.3390/v14020328.

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The production of the aquaculture industry has increased to be equal to that of the world fisheries in recent years. However, aquaculture production faces threats such as infectious diseases. Betanodaviruses induce a neurological disease that affects fish species worldwide and is caused by nervous necrosis virus (NNV). NNV has a nude capsid protecting a bipartite RNA genome that consists of molecules RNA1 and RNA2. Four NNV strains distributed worldwide are discriminated according to sequence homology of the capsid protein encoded by RNA2. Since its first description over 30 years ago, the vir

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9

Lee, Ang-Jung, Hong-Jun Liao, and Jiann-Ruey Hong. "Overexpression of Bcl2 and Bcl2L1 Can Suppress Betanodavirus-Induced Type III Cell Death and Autophagy Induction in GF-1 Cells." Symmetry 14, no. 2 (2022): 360. http://dx.doi.org/10.3390/sym14020360.

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Betanodavirus infection induces viral nervous necrosis (VNN) in fish. However, the role of cell death and autophagy in the pathogenesis of VNN remains unknown. This study aimed to investigate the effect of red-spotted grouper nervous necrosis virus (RGNNV) infection on Bcl2 downregulation and overexpression on asymmetric interaction between cell death and autophagy. The mRFP-LC3 reporter system was used to identify autophagosome formation in GF-1 (Grouper fin-1) fish cells. We found that the RGNNV could strongly induce autophagosome formation 36 h post-infection (hpi) after autophagy inhibitor

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10

Wang, Qing, Cheng Peng, Min Yang, et al. "Single-cell RNA-seq landscape midbrain cell responses to red spotted grouper nervous necrosis virus infection." PLOS Pathogens 17, no. 6 (2021): e1009665. http://dx.doi.org/10.1371/journal.ppat.1009665.

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Viral nervous necrosis (VNN) is an acute and serious fish disease caused by nervous necrosis virus (NNV) which has been reported massive mortality in more than fifty teleost species worldwide. VNN causes damage of necrosis and vacuolation to central nervous system (CNS) cells in fish. It is difficult to identify the specific type of cell targeted by NNV, and to decipher the host immune response because of the functional diversity and highly complex anatomical and cellular composition of the CNS. In this study, we found that the red spotted grouper NNV (RGNNV) mainly attacked the midbrain of or

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11

Barsøe, Sofie, Anna Toffan, Francesco Pascoli, et al. "Long-Term Protection and Serologic Response of European Sea Bass Vaccinated with a Betanodavirus Virus-Like Particle Produced in Pichia pastoris." Vaccines 9, no. 5 (2021): 447. http://dx.doi.org/10.3390/vaccines9050447.

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Viral Nervous Necrosis (VNN) causes high mortality and reduced growth in farmed European sea bass (Dicentrarchus labrax) in the Mediterranean. In the current studies, we tested a novel Pichia-produced virus-like particle (VLP) vaccine against VNN in European sea bass, caused by the betanodavirus “Red-Spotted Grouper Nervous Necrosis Virus” (RGNNV). European sea bass were immunized with a VLP-based vaccine formulated with different concentrations of antigen and with or without adjuvant. Antibody response was evaluated by ELISA and serum neutralization. The efficacy of these VLP-vaccine formulat

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12

Wu, Riming, Jinze Li, Zhenyu Liang, et al. "Characterization of SNX5 in Orange-Spotted Grouper (Epinephelus coioides) during In Vitro Viral Infection." Fishes 8, no. 5 (2023): 231. http://dx.doi.org/10.3390/fishes8050231.

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SNX5 is a protein that is involved in endosomal sorting, signal transduction and endocytosis pathways. However, the roles of fish SNX5 were largely unknown. In this study, we identified an SNX5 homolog (EcSNX5) from an orange-spotted grouper (E. coioides) and investigated its role during viral infection. EcSNX5 encoded 412 amino acids with a PX domain and a BAR domain. In addition, it shared high identities with other known fish SNX5. Through quantitative real-time polymerase chain reaction (qRT-PCR), the high expression of EcSNX5 was observed in the head, kidney and heart. After stimulation w

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13

Liu, Wei, Yilin Jin, Wanwan Zhang, et al. "MiR-202-5p Inhibits RIG-I-Dependent Innate Immune Responses to RGNNV Infection by Targeting TRIM25 to Mediate RIG-I Ubiquitination." Viruses 12, no. 3 (2020): 261. http://dx.doi.org/10.3390/v12030261.

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The RIG-I-like receptors (RLRs) signaling pathway is essential for inducing type I interferon (IFN) responses to viral infections. Meanwhile, it is also tightly regulated to prevent uncontrolled immune responses. Numerous studies have shown that microRNAs (miRNAs) are essential for the regulation of immune processes, however, the detailed molecular mechanism of miRNA regulating the RLRs signaling pathway remains to be elucidated. Here, our results showed that miR-202-5p was induced by red spotted grouper nervous necrosis virus (RGNNV) infection in zebrafish. Overexpression of miR-202-5p led to

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14

Gemez-Mata, Juan, Patricia Moreno, Daniel Alvarez-Torres, Esther Garcia-Rosado, Julia Bejar, and M. Carmen Alonso. "Comparative Analysis of Immune Gene Transcription in Sea Bream (Sparus aurata) Challenged with RGNNV or RGNNV/SJNNV Betanodaviruses." Pathogens 13, no. 6 (2024): 478. http://dx.doi.org/10.3390/pathogens13060478.

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Gilthead sea bream and European sea bass display different resistance–susceptibility patterns during infection with different nervous necrosis virus (NNV) species, which may derive from differences in the triggered immune response. Based on this premise, we analysed the transcription of several selected immune-related genes in sea bream experimentally infected with NNV isolates obtained from sea bass (DlNNV, RGNNV) or sea bream (SaNNV, RGNNV/SJNNV). Viral replication only occurred in SaNNV-inoculated fish; therefore, the differences between the immune response elicited by both viruses may be t

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15

Kim, Young Chul, Joon Gyu Min, Kwang Il Kim, and Hyun Do Jeong. "Emergence of Reassortment between a New and Reported Types of Betanodavirus in Shellfish." Pathogens 10, no. 10 (2021): 1232. http://dx.doi.org/10.3390/pathogens10101232.

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Recently, three types of betanodavirus including red spotted grouper nervous necrosis virus (RGNNV), barfin flounder nervous necrosis virus (BFNNV), and Korean shellfish nervous necrosis virus (KSNNV) (proposed as a new fifth type) have been detected in shellfish in the marine environment around Korea. To investigate the presence of reassortment between betanodavirus types, the type based on the RNA2 segment of betanodaviruses carried in 420 domestic shellfish (n = 306) and finfish (n = 35), as well as imported shellfish (n = 79), was compared with the type identified by reverse-transcriptase

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16

Olveira, J. G., S. Souto, C. P. Dopazo, R. Thiéry, J. L. Barja, and I. Bandín. "Comparative analysis of both genomic segments of betanodaviruses isolated from epizootic outbreaks in farmed fish species provides evidence for genetic reassortment." Journal of General Virology 90, no. 12 (2009): 2940–51. http://dx.doi.org/10.1099/vir.0.013912-0.

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Sequencing of the full coding region of both genomic segments of seven betanodavirus strains isolated from different farmed species in Spain and Portugal revealed that six were reassortants, exhibiting a red-spotted grouper nervous necrosis virus (RGNNV)-type RNA1 and a striped jack nervous necrosis virus (SJNNV)-type RNA2. Analysis of sequences of reassortant strains at both the genomic and protein levels revealed the existence of differences compared with type strains of both genotypes. These differences were greater in the polymerase sequence, which is remarkable because viral structural pr

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17

Li, Chen, Jingguang Wei, Xin Zhang, Mengshi Sun, Siting Wu, and Qiwei Qin. "Fish TRAF2 promotes innate immune response to RGNNV infection." Fish & Shellfish Immunology 102 (July 2020): 108–16. http://dx.doi.org/10.1016/j.fsi.2020.04.021.

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18

Toubanaki, Dimitra K., and Evdokia Karagouni. "Towards a Dual Lateral Flow Nanobiosensor for Simultaneous Detection of Virus Genotype-Specific PCR Products." Journal of Analytical Methods in Chemistry 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/7691014.

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Nervous necrosis virus (nodavirus) has been responsible for mass mortalities in aquaculture industry worldwide, with great economic and environmental impact. A rapid low-cost test to identify nodavirus genotype could have important benefits for vaccine and diagnostic applications in small- and medium-scale laboratories in both academia and fish farming industry. A dual lateral flow biosensor for simultaneous detection of the most prevalent nodavirus genotypes (RGNNV and SJNNV) was developed and optimized. The dual biosensor consisted of two antibody-based test zones, indicative of each genotyp

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19

Li, Wen, Zhi Wang, Jingjie Liang, Bilin Xia, Ruoxue Chen, and Tiansheng Chen. "Role of Medaka (Oryzias latipes) Foxo3 in Resistance to Nervous Necrosis Virus Infection." Animals 14, no. 11 (2024): 1587. http://dx.doi.org/10.3390/ani14111587.

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Upon encountering a virus, fish initiate an innate immune response, guided by IFNs. Foxo3 plays a part in the body’s immune response; however, its specific role in the IFN-guided immune response in fish is yet to be clarified. In this study, we characterized foxo3 in Japanese medaka (Oryzias latipes) and examined its role in the IFN-dependent immune response upon infection with the RGNNV. The results show that the coding region of the medaka foxo3 gene is 2007 base pairs long, encoding 668 amino acids, and possesses a typical forkhead protein family structural domain. The product of this gene

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20

Chen, Yongzhi, Yun Liu, Qing Wang, and Xilan Ma. "Inhibition of RGNNV by dsRNA in the orange-spotted grouper." Aquaculture Reports 23 (April 2022): 101035. http://dx.doi.org/10.1016/j.aqrep.2022.101035.

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21

Liu, Shaoli, Xiaoxia Lei, Helong Cao, et al. "Antiviral role of grouper FoxO1 against RGNNV and SGIV infection." Fish & Shellfish Immunology 142 (November 2023): 109168. http://dx.doi.org/10.1016/j.fsi.2023.109168.

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22

Yuan, Yongming, Xiaohong Huang, Lei Zhang, et al. "Medaka haploid embryonic stem cells are susceptible to Singapore grouper iridovirus as well as to other viruses of aquaculture fish species." Journal of General Virology 94, no. 10 (2013): 2352–59. http://dx.doi.org/10.1099/vir.0.054460-0.

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Viral infection is a challenge in high-density aquaculture, as it leads to various diseases and causes massive or even complete loss. The identification and disruption of host factors that viruses utilize for infection offer a novel approach to generate viral-resistant seed stocks for cost-efficient and sustainable aquaculture. Genetic screening in haploid cell cultures represents an ideal tool for host factor identification. We have recently generated haploid embryonic stem (ES) cells in the laboratory fish medaka. Here, we report that HX1, one of the three established medaka haploid ES cell

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23

Peñalver, José, Emilio María-Dolores, José Antonio García-Charton, et al. "Mortality by nodavirus in grouper (Epinephelus marginatus L., 1758) from the Cabo de Palos and Islas Hormigas Marine Reserve, Murcia." Anales de Biología, no. 42 (April 20, 2020): 53–62. http://dx.doi.org/10.6018/analesbio.42.07.

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Los nodavirus afectan a gran número de especies de peces, silvestres y cultivadas. En silvestres se ha aislado en diversas especies, pero nunca se había asociado con procesos clínicos en el litoral de Murcia. En otoño de 2017, se detectaron diversos ejemplares de meros (Epinephelus marginatus y E. costae) en la Reserva de Cabo de Palos con sintomatología clínica compatible con nodavirus. La infección por nodavirus fue confirmada mediante RT-PCR en tiempo real y su posterior genotipado (tipo RGNNV). Este hallazgo constituye la primera evidencia regional de infección clínica por nodavirus en pec

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24

Furusawa, Ryo, Yasushi Okinaka, and Toshihiro Nakai. "Betanodavirus infection in the freshwater model fish medaka (Oryzias latipes)." Journal of General Virology 87, no. 8 (2006): 2333–39. http://dx.doi.org/10.1099/vir.0.81761-0.

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Betanodaviruses, the causal agents of viral nervous necrosis in marine fish, have bipartite, positive-sense RNA genomes. As their genomes are the smallest and simplest among viruses, betanodaviruses have been studied in detail as model viruses by using a genetic-engineering system, as has occurred with the insect alphanodaviruses, the other members of the family Nodaviridae. However, studies of virus–host interactions have been limited, as betanodaviruses basically infect marine fish at early developmental stages (larval and juvenile). These fish are only available for a few months of the year

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Nishi, Shinnosuke, Hirofumi Yamashita, Yasuhiko Kawato, and Toshihiro Nakai. "Cell Culture Isolation of Piscine Nodavirus (Betanodavirus) in Fish-Rearing Seawater." Applied and Environmental Microbiology 82, no. 8 (2016): 2537–44. http://dx.doi.org/10.1128/aem.03834-15.

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ABSTRACTPiscine nodavirus (betanodavirus) is the causative agent of viral nervous necrosis (VNN) in a variety of cultured fish species, particularly marine fish. In the present study, we developed a sensitive method for cell culture isolation of the virus from seawater and applied the method to a spontaneous fish-rearing environment. The virus in seawater was concentrated by an iron-based flocculation method and subjected to isolation with E-11 cells. A real-time reverse transcriptase PCR (RT-PCR) assay was used to quantify the virus in water. After spiking into seawater was performed, a betan

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Kaplan, M., K. Pekmez, B. Özkan, AA Çağırgan, and G. Kalaycı. "Detection of RGNNV genotype betanodavirus in the Black Sea and monitoring studies." Diseases of Aquatic Organisms 144 (April 22, 2021): 117–21. http://dx.doi.org/10.3354/dao03583.

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Viral nervous necrosis (VNN), caused by betanodavirus, is a significant viral infection that threatens marine aquaculture. Freshwater and marine fish farms in Turkey are subjected to annual pathogen screenings. In 2016, during the Nervous Necrosis Virus screening program conducted in the Black Sea, betanodavirus was unexpectedly detected using real-time reverse transcription-polymerase chain reaction in apparently healthy sea bass. Phylogenetic analysis of both the RNA1 and RNA2 segments of the virus determined that the betanodavirus detected was red-spotted grouper nervous necrosis virus geno

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Li, Chen, Jiaxin Liu, Xin Zhang, et al. "Red grouper nervous necrosis virus (RGNNV) induces autophagy to promote viral replication." Fish & Shellfish Immunology 98 (March 2020): 908–16. http://dx.doi.org/10.1016/j.fsi.2019.11.053.

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Cherif, N., B. Lopez-Jimena, E. Garcia-Rosado, et al. "Detection of SJNNV and RGNNV genotypes using a relative quantification RT-PCR assay." Journal of Applied Ichthyology 27, no. 3 (2010): 805–12. http://dx.doi.org/10.1111/j.1439-0426.2010.01592.x.

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Toffan, A., L. Biasini, T. Pretto, et al. "Age dependency of RGNNV/SJNNV viral encephalo-retinopathy in Gilthead Sea Bream (Sparus aurata)." Aquaculture 539 (June 2021): 736605. http://dx.doi.org/10.1016/j.aquaculture.2021.736605.

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Chérif, Nadia, Fatma Amdouni, Boutheina Bessadok, Ghada Tagorti, and Saloua Sadok. "Chitosan Treatment of E-11 Cells Modulates Transcription of Nonspecific Immune Genes and Reduces Nodavirus Capsid Protein Gene Expression." Animals 11, no. 11 (2021): 3097. http://dx.doi.org/10.3390/ani11113097.

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This study explores whether crustacean products inhibit viral infections in aquaculture. Chitosan (CHT) was extracted from waste products of Parapenaeus longirostris. Biochemical composition, viscosity measurement, molecular weight, structure and cytotoxicity tests were used to characterize the extracted chitosan. Cultures of E-11 cells derived from snakehead Ophicephalus striatus were inoculated with 106.74 TCID50 of an isolate of betanodavirus genotype RGNNV (redspotted grouper nervous necrosis virus) after being treated with solutions of 0.3% CHT for 1 h at room temperature. The antiviral e

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Moreno, Patricia, Rocio Leiva-Rebollo, Esther Garcia-Rosado, Julia Bejar, and M. Carmen Alonso. "Cytokine-like activity of European sea bass ISG15 protein on RGNNV-infected E−11 cells." Fish & Shellfish Immunology 128 (September 2022): 612–19. http://dx.doi.org/10.1016/j.fsi.2022.08.048.

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Wu, Horng-Cherng, Jen-Leih Wu, Heuy-Ling Chu, Yu-Chin Su, and Jiann-Ruey Hong. "RGNNV induces mitochondria-mediated cell death via newly synthesized protein dependent pathway in fish cells." Fish & Shellfish Immunology 29, no. 3 (2010): 451–63. http://dx.doi.org/10.1016/j.fsi.2010.05.003.

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Volpe, E., N. Pagnini, P. Serratore, and S. Ciulli. "Fate of redspotted grouper nervous necrosis virus (RGNNV) in experimentally challenged Manila clam Ruditapes philippinarum." Diseases of Aquatic Organisms 125, no. 1 (2017): 53–61. http://dx.doi.org/10.3354/dao03139.

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Souto, Sandra, José G. Olveira, M. Carmen Alonso, Carlos P. Dopazo, and Isabel Bandín. "Betanodavirus infection in bath-challengedSolea senegalensisjuveniles: A comparative analysis of RGNNV, SJNNV and reassortant strains." Journal of Fish Diseases 41, no. 10 (2018): 1571–78. http://dx.doi.org/10.1111/jfd.12865.

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Wei, Jingguang, Shaoqing Zang, Chen Li, Xin Zhang, Pin Gao, and Qiwei Qin. "Grouper PKR activation inhibits red-spotted grouper nervous necrosis virus (RGNNV) replication in infected cells." Developmental & Comparative Immunology 111 (October 2020): 103744. http://dx.doi.org/10.1016/j.dci.2020.103744.

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Palaiokostas, Christos, Sophie Cariou, Anastasia Bestin, et al. "Genome-wide association and genomic prediction of resistance to viral nervous necrosis in European sea bass (Dicentrarchus labrax) using RAD sequencing." Genetics Selection Evolution 50, no. 1 (2018): 30. https://doi.org/10.1186/s12711-018-0401-2.

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<strong>Background: </strong>European sea bass (<i>Dicentrarchus labrax</i>) is one of the most important species for European aquaculture. Viral nervous necrosis (VNN), commonly caused by the redspotted grouper nervous necrosis virus (RGNNV), can result in high levels of morbidity and mortality, mainly during the larval and juvenile stages of cultured sea bass. In the absence of efficient therapeutic treatments, selective breeding for host resistance offers a promising strategy to control this disease. Our study aimed at investigating genetic resistance to VNN and genomic-based approaches to

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KERSTING, DIEGO K., CELIA GARCÍA-QUINTANILLA, NAGORE QUINTANO, ITZIAR ESTENSORO, and MARÍA DEL MAR ORTEGA-VILLAIZAN. "Dusky grouper massive die-off in a Mediterranean marine reserve." Mediterranean Marine Science 25, no. 3 (2024): 578–85. http://dx.doi.org/10.12681/mms.38147.

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The dusky grouper Epinephelus marginatus (Lowe, 1834) is a key predator in shallow Mediterranean rocky habitats. Due to fishing pressure and slow population dynamics, dusky grouper populations are declining across their distribution range. Here we document a massive die-off of E. marginatus in the Columbretes Islands Marine Reserve (NW Mediterranean Sea) during the summer and early autumn of 2023. The mortality event was triggered by a Betanodavirus infection. Genetic characterization of isolates from the affected fish confirmed that they belong to the RGNNV genotype. Our findings indicate tha

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Huang, Fengqi, Jinhong Shan, Kaishan Liang, et al. "A new method to detect red spotted grouper neuro necrosis virus (RGNNV) based on CRISPR/Cas13a." Aquaculture 555 (June 2022): 738217. http://dx.doi.org/10.1016/j.aquaculture.2022.738217.

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Park, Mirye, Sung-Suk Suh, Jinik Hwang, et al. "Production of Red-spotted Grouper Nervous Necrosis Virus (RGNNV) Capsid Protein Using Saccharomyces cerevisiae Surface Display." Journal of Life Science 24, no. 9 (2014): 995–1000. http://dx.doi.org/10.5352/jls.2014.24.9.995.

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Zang, Shaoqing, Xin Zhang, Chen Li, Liqun Wang, Jingguang Wei, and Qiwei Qin. "HRI of Epinephelus coioides is a critical factor in the grouper immune response to RGNNV infection." Fish & Shellfish Immunology 87 (April 2019): 659–68. http://dx.doi.org/10.1016/j.fsi.2019.02.011.

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Puspasari, Khumaira, Zakiyah Widowati, Freddy Riatmono, Ade Nurdin, Hasriani Hasriani, and Ishaaq Saputra. "Pemetaan Genomik Daerah RNA2 (Coat Protein) Betanodavirus Penyebab Penyakit Viral Nervous Necrosis (VNN)." Jurnal Kelautan dan Perikanan Terapan (JKPT) 3, no. 2 (2020): 79. http://dx.doi.org/10.15578/jkpt.v3i2.9375.

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Ikan kerapu dan kakap merupakan komoditas ikan penting di Indonesia yang memiliki berbagai jenis spesies maupun hasil silangannya. Salah satu permasalahan dalam kegiatan budidaya kelompok ikan ini yaitu adanya ancaman serangan virus Viral Necrosis Virus (VNN). Pada penelitian ini, dilakukan upaya pemetaan Betanodavirus sebagai penyebab VNN pada sentra budidaya ikan kerapu maupun kakap di wilayah Indonesia. Pemetaan genomik daerah RNA2 (coat protein) Betanodavirus dilakukan berdasarkan pada sejumlah 355 ekor ikan sampel dengan berbagai ukuran. Pengujian Betanodavirus dilakukan dengan metode Rev

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Chen, Cen, Kenli Li, Sin G. Teo, et al. "Gated Residual Recurrent Graph Neural Networks for Traffic Prediction." Proceedings of the AAAI Conference on Artificial Intelligence 33 (July 17, 2019): 485–92. http://dx.doi.org/10.1609/aaai.v33i01.3301485.

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Traffic prediction is of great importance to traffic management and public safety, and very challenging as it is affected by many complex factors, such as spatial dependency of complicated road networks and temporal dynamics, and many more. The factors make traffic prediction a challenging task due to the uncertainty and complexity of traffic states. In the literature, many research works have applied deep learning methods on traffic prediction problems combining convolutional neural networks (CNNs) with recurrent neural networks (RNNs), which CNNs are utilized for spatial dependency and RNNs

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Chen, Xiaoqi, Wanwan Zhang, Zhe Hu, Kuopeng Cui, Meisheng Yi, and Kuntong Jia. "Sea perch (Lateolabrax japonicus) autophagy related gene 5 promotes RGNNV infection via inhibiting RLRs-interferon signaling pathway." Fish & Shellfish Immunology 127 (August 2022): 910–17. http://dx.doi.org/10.1016/j.fsi.2022.07.041.

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Falco, Alberto, Melissa Bello-Perez, Rocío Díaz-Puertas, Matthew Mold, and Mikolaj Adamek. "Update on the Inactivation Procedures for the Vaccine Development Prospects of a New Highly Virulent RGNNV Isolate." Vaccines 9, no. 12 (2021): 1441. http://dx.doi.org/10.3390/vaccines9121441.

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Viral nervous necrosis (VNN) caused by the nervous necrosis virus (NNV) affects a broad range of primarily marine fish species, with mass mortality rates often seen among larvae and juveniles. Its genetic diversification may hinder the effective implementation of preventive measures such as vaccines. The present study describes different inactivation procedures for developing an inactivated vaccine against a new NNV isolate confirmed to possess deadly effects upon the European seabass (Dicentrarchus labrax), an important Mediterranean farmed fish species that is highly susceptible to this dise

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Krishna Priya, R. S., Avinash Premraj, K. C. Sivakumar, and T. P. Sajeevan. "Identification of two ISG15 homologues involved in host immune response against RGNNV in Asian seabass (Lates calcarifer)." Fish and Shellfish Immunology Reports 3 (December 2022): 100054. http://dx.doi.org/10.1016/j.fsirep.2022.100054.

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Moreno, Patricia, Daniel Alvarez-Torres, Esther Garcia-Rosado, Juan J. Borrego, and M. Carmen Alonso. "Differential antiviral activity of European sea bass interferon-stimulated 15 protein (ISG15) against RGNNV and SJNNV betanodaviruses." Fish & Shellfish Immunology 83 (December 2018): 148–57. http://dx.doi.org/10.1016/j.fsi.2018.09.022.

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Jia, Peng, Wanwan Zhang, Yangxi Xiang, et al. "Ubiquitin-specific protease 5 was involved in the interferon response to RGNNV in sea perch (Lateolabrax japonicus)." Fish & Shellfish Immunology 103 (August 2020): 239–47. http://dx.doi.org/10.1016/j.fsi.2020.04.065.

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Jia, Peng, Wei Liu, Limin Chen, et al. "Identification of sea perch ( Lateolabrax japonicus ) ribonucleoprotein PTB-Binding 1 involved in antiviral immune response against RGNNV." Fish & Shellfish Immunology 60 (January 2017): 119–28. http://dx.doi.org/10.1016/j.fsi.2016.11.047.

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Agnihotri, K., R. Chong, D. Underwood, C. Kistler, and M. Hutchison. "Betanodavirus infection in Kuhlia rupestris and Ambassis marianus and isolation of betanodavirus from infected pond water." Diseases of Aquatic Organisms 142 (November 5, 2020): 1–11. http://dx.doi.org/10.3354/dao03528.

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This is the first report of betanodavirus infection in 2 species of finfish, Kuhlia rupestris (jungle perch) and Ambassis marianus (estuary perchlet). This report also describes isolation of betanodavirus from infected pond water using the SSN-1 cell line. Histopathology of K. rupestris larvae revealed vacuolation in the eye and brain, which was confirmed using betanodavirus-specific immunohistochemistry. The eye and brain from A. marianus and betanodavirus isolated from pond water were confirmed using real-time PCR and Sanger sequencing. High throughput sequencing was used to obtain betanodav

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Lampou, Eirini, Chrysostomos Dovas, Maritsa Margaroni, et al. "Investigation of routes of entry and dispersal pattern of RGNNV in tissues of European sea bass, Dicentrarchus labrax." Journal of Fish Diseases 43, no. 11 (2020): 1363–71. http://dx.doi.org/10.1111/jfd.13215.

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