Log in

Relevant bibliographies by topics / Rhabdomyosarcoma / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Rhabdomyosarcoma.

Dissertations / Theses on the topic 'Rhabdomyosarcoma'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Rhabdomyosarcoma.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Anderson, William John. "Molecular characterisation of rhabdomyosarcoma." Thesis, Institute of Cancer Research (University Of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312950.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Scrable, Heidi. "Molecular genetics of childhood rhabdomyosarcoma." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74265.

Full text

Abstract:

Rhabdomyosarcoma is a class of malignant neoplasms composed of cells histologically resembling fetal striated muscle. It is the most common soft tissue tumor of children, adolescents, and young adults. In this Thesis, I demonstrate that the rhabdomyosarcoma tumor class is delimited in molecular genetic terms by the expression of the MyoD gene, and that loss of alleles on chromosome 11 distinguishes between the embryonal and alveolar subtypes. The elucidation of this genotypic distinction resolved the paradox between phenotypic variation and an apparent histogenetic relatedness between and amon

APA, Harvard, Vancouver, ISO, and other styles

3

Poli, Elena. "DNA METHYLATION ANALYSIS IN RHABDOMYOSARCOMA." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424380.

Full text

Abstract:

Rhabdomyosarcoma (RMS) is a highly aggressive pediatric soft-tissue sarcoma. It is mainly classified into two major subtypes characterized by alveolar (ARMS) and embryonal (ERMS) histologies. ARMS are characterized by a more aggressive behavior with a higher tendency to present metastasis at diagnosis and to relapse after treatment. Approximately 80% of ARMS harbour the reciprocal chromosomal translocation t(2;13)(q35;q14) and, less commonly, the variant translocation t(1;13)(p36;q14), in which PAX3 and FOXO1, or PAX7 and FOXO1 genes, respectively, are juxtaposed. Unfortunately, no such specif

APA, Harvard, Vancouver, ISO, and other styles

4

Chalk, Jeremy. "A molecular genetic investigation of rhabdomyosarcoma." Thesis, Open University, 1997. http://oro.open.ac.uk/57658/.

Full text

Abstract:

Alveolar rhabdomyosarcoma is characterised by a t(2;13)(q35;qI4) chromosome translocation, which leads to the fusion of the P AX3 artd the FKHR genes. The resulting fusion gene encodes a chimeric protein which has aberrant transcriptional activity. The data here describes the molecular definition of the genomic breakpoints on both derivative chromosomes in one case and the derivative chromosome 13 breakpoints in two other cases. The DNA sequences adjacent to the breakpoints on the derivative chromosome 13 are remarkable for their resemblartce to recognition sequences for the protein trartslin.

APA, Harvard, Vancouver, ISO, and other styles

5

Roberts, Ian. "Molecular cytogenetic analysis of paediatric rhabdomyosarcoma." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621125.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Mohamed, Abdalla Ahmed Diaai. "The Hippo effector TAZ in rhabdomyosarcoma." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228577.

Full text

Abstract:

Persistent hyperactivity of the Hippo effector YAP in activated but not quiescent satellite cells (muscle stem cells) can give rise to embryonal rhabdomyosarcoma (ERMS). Taz is a paralogue of Yap and both have similar functions in most cell types. However, one report has suggested that Taz can, unlike Yap, promote the differentiation of myoblasts into myotubes. To further characterise the role of Taz in the muscle lineage and rhabdomyosarcoma TAZ abundance and localisation in rhabdomyosarcoma tissue arrays were assessed to test for association with clinical outcome. Additionally, wildtype TAZ

APA, Harvard, Vancouver, ISO, and other styles

7

Gavino, Belinda Joy E. "Nickel induced rhabdomyosarcoma in cultured cardiac myocytes." Tallahassee, Fla. : Florida State University, 2008. http://purl.fcla.edu/fsu/lib/digcoll/undergraduate/honors-theses/341766.

Full text

Abstract:

Thesis (Honors paper)--Florida State University, 2008.<br>Advisor: Dr. P. Bryant Chase, Florida State University, College of Arts and Sciences, Dept. of Biological Science. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

8

Sun, Danqiong. "Molecular mechanisms in myogenesis and in rhabdomyosarcoma." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/2751.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Feldmann, Jamie. "Analysis of myogenin function in rhabdomyosarcoma cells /." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1885443171&sid=5&Fmt=2&clientId=1509&RQT=309&VName=PQD.

Full text

Abstract:

Thesis (M.S.)--Southern Illinois University Carbondale, 2009.<br>"Department of Molecular Biology, Microbiology and Biochemistry." Includes bibliographical references (p. 46-48). Also available online.

APA, Harvard, Vancouver, ISO, and other styles

10

Annavarapu, Srinivas Rao. "Characterisation of Wnt signalling pathway in rhabdomyosarcoma." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3009225/.

Full text

Abstract:

Introduction: Rhabdomyosarcoma (RMS) remains one of the most challenging tumours in paediatric oncology, accounting for around 5% of all malignant paediatric tumours. Of the two major subtypes of RMS, embryonal and alveolar, the latter portends a poorer clinical outcome. Canonical Wnt signalling pathway is an important evolutionarily conserved signalling pathway that is required for muscle development and embryonal somite patterning. β-Catenin is a potent nuclear transcriptional activator and is the central effector of the canonical Wnt signalling pathway. Interestingly, constitutional activat

APA, Harvard, Vancouver, ISO, and other styles

11

Feldmann, Jamie Marie. "Analysis of Myogenin Function in Rhabdomyosarcoma Cells." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/theses/7.

Full text

Abstract:

Rhabdomyosarcomas (RMS) are the most common soft tissue cancer among children and are characterized by their expression of the myogenic regulatory factors MyoD and myogenin. Yet RMS cells cannot undergo normal myogenesis and are caught between the proliferation program and the terminal differentiation program. Many questions still remain about the defects present in rhabdomyosarcoma cells. In this work, we set out to understand the role of myogenin in these cells. To begin, we found that myogenin and its co-factors were present in rhabdomyosarcoma cells at levels that should support termina

APA, Harvard, Vancouver, ISO, and other styles

12

Cocker, Hilary Anne. "Drug resistance in paediatric rhabdomyosarcoma : pathways and circumvention." Thesis, Institute of Cancer Research (University Of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250655.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Price, Richard Lee III. "The Role of Cytomegalovirus in Glioblastoma and Rhabdomyosarcoma." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343432690.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Vial, Jonathan. "Dérégulations de la mort cellulaire dans les rhabdomyosarcomes : étude du rôle du transporteur mitochondrial ANT1." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEP016.

Full text

Abstract:

Le rhabdomyosarcome (RMS) est la forme la plus fréquente de sarcome des tissus mous chez l'enfant. On distingue 2 sous-types principaux: ERMS (embryonnaire) et ARMS (alvéolaire). Les traitements actuels sont basés sur la chimiothérapie, la chirurgie et la radiothérapie. Le taux de survie à 5 ans reste de 70% depuis 2000, malgré plusieurs essais cliniques. Il est donc essentiel de pouvoir mieux comprendre leurs bases moléculaires pour pouvoir dans l’avenir mieux les soigner. Mon projet de thèse s’est inscrit dans cette perspective, en cherchant à mieux définir les mécanismes à l’origine de la r

APA, Harvard, Vancouver, ISO, and other styles

15

Malone, Caroline Mary Patricia. "The function of Hes6 in myogenesis, rhabdomyosarcoma and neurogenesis." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609453.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Lee, Min-Hyung. "The Function of SUV39H Histone Methyltransferase in Alveolar Rhabdomyosarcoma." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1283373657.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Roumes, Hélène. "Étude de l'implication du système protéolytique neutre calcium-dépendant dans la migration des cellules musculaires tumorales." Thesis, Bordeaux 1, 2009. http://www.theses.fr/2009BOR13948/document.

Full text

Abstract:

Les Rhabdomyosarcomes (RMS) sont des sarcomes qui touchent préférentiellement les enfants et les adolescents. Les RMS sont à l'origine de nombreuses métastases qui sont responsables d'une réduction importante de l'espérance de vie du malade. Une meilleure compréhension des mécanismes sous-tendant la migration et l'invasion des RMS pourrait orienter vers de nouvelles thérapies visant à enrayer le développement de métastases. La dissémination métastatique fait intervenir de nombreuses protéases dont la µ- et la m-calpaïne, cystéine-protéases, constituant avec leur inhibiteur endogène, la calpast

APA, Harvard, Vancouver, ISO, and other styles

18

Pandita, Ajay. "Molecular cytogenetic analysis and gene amplification in rhabdomyosarcoma and neuroblastoma." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0028/NQ49926.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Albacker, Colleen Elizabeth. "Chromatin-Modifying Factors in Zebrafish Models of Rhabdomyosarcoma and Hematopoiesis." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10098.

Full text

Abstract:

Epigenetics, or the reversible and heritable marks of gene regulation not including DNA sequence, encompasses modifications on both the DNA and histones and is as important as the DNA sequence itself. Gene transcription, DNA repair, DNA replication, and the cell cycle are each impacted by the chromatin structure. A variety of enzymes modulate these modifications, and a suite of factors interacts with them to aid in promoting or inhibiting cellular functions. Many of these chromatin-modifying factors are deregulated in cancer, making them novel therapeutic targets. This dissertation describ

APA, Harvard, Vancouver, ISO, and other styles

20

Mashud, Ahmed Abdallah. "Down-regulation of PAX3 gene expression in rhabdomyosarcoma and melanoma." Thesis, Manchester Metropolitan University, 2014. http://e-space.mmu.ac.uk/332146/.

Full text

Abstract:

The PAX3 gene as a member of the paired homeodomain family of transcription factors plays a crucial role during embryonal development by regulating the early development of neural structures, derivatives of the neural crest and skeletal muscles. Following embryonal development, the PAX3 expression is switched off. Mutations in the PAX3 gene are commonly associated with Waardenburg’s syndrome and in Craniofacial-hand syndrome. Aberrant re-expression of PAX3 after embryogenesis plays a key role in the onset, growth, survival and progression of rhabdomyosarcoma, melanoma and neuroblastoma. Altern

APA, Harvard, Vancouver, ISO, and other styles

21

Sims, Danica Anne. "The role of T-box transcription factor TBX3 in rhabdomyosarcoma." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/28264.

Full text

Abstract:

Cancer remains one of the leading causes of death worldwide due to late diagnosis and ineffective treatment options. To address this problem requires the elucidation of the molecular mechanisms, including the signaling pathways and transcription factors that drive cancer initiation and progression. In this regard, our laboratory has been particularly interested in the embryonically important T - box family of transcription factors which has been heavily implicated in promoting initiation and progression of a long list of cancers. For example, the overexpression of the T - box factor TBX3, ha

APA, Harvard, Vancouver, ISO, and other styles

22

Roeb, Wendy Linette. "The role of PAX3-FOXO1 in the pathogenesis of alveolar rhabdomyosarcoma." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3274591.

Full text

Abstract:

Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed June 2, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

23

Leddon, Jennifer. "Oncolytic Herpes Simplex Virus Therapy for the Treatment of Pediatric Rhabdomyosarcoma." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427980753.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Wolf, Steven J. "In vitro assessment of novel DNA binding agents in rhabdomyosarcoma cells." Thesis, The University of Sydney, 2009. https://hdl.handle.net/2123/28936.

Full text

Abstract:

Despite significant improvements in the treatment of non-metastatic embryonal rhabdomyosarcoma (ERMS) in the past 30 years, patients with metastatic ERMS and alveolar RMS (ARMS) continue to face a poor prognosis. This is due, in part, to a lack of response of the tumours to current the chemotherapy options. In this study, novel topoisomerase poisons and transcription inhibitors are assessed in a panel of human transformed RMS cell lines of both ERMS and ARMS subtypes, as well as mouse primary ARMS cell lines. Revealed are variable cell responses following exposure to a novel topoisomera

APA, Harvard, Vancouver, ISO, and other styles

25

Kazim, Noor Ali. "MOLECULAR INSIGHTS INTO TCEA3 AND TCEAL7-MEDIATED DIFFERENTIATION AND APOPTOSIS IN RHABDOMYOSARCOMA." OpenSIUC, 2018. https://opensiuc.lib.siu.edu/dissertations/1630.

Full text

Abstract:

Rhabdomyosarcoma (RMS) is a highly malignant form of pediatric cancer that originates from skeletal muscle cells. While the normal skeletal muscle cells are generated via a highly regulated process called myogenesis that depends on myogenic regulatory factors (MRFs), the RMS cells fail to differentiate as a result of impaired myogenesis due to abnormal MRF activity. We found that TCEA3 regulates myogenin (an essential MRF member) activity at the gene expression level. Our work showed that depletion of TCEA3 in normal myoblast cells results in an inhibition of differentiation and downregulation

APA, Harvard, Vancouver, ISO, and other styles

26

Cen, Ling. "Phosphorylation profiling and targeting of oncogenic signaling proteins in cancer cells." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186666790.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Rapa, Elizabeth. "Characterisation of the differences in gene expression between rhabdomyosarcoma cells and myoblasts." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510209.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Dias, Peter Bento Ernest. "A study of childhood rhabdomyosarcoma with respect to diagnosis, prognosis and histogenesis." Thesis, Manchester Metropolitan University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329377.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

ZHU, BO. "TBX2 IS INVOLVED IN MYOGENESIS AND ITS DEREGULATION PROMOTES TUMORIGENESIS IN RHABDOMYOSARCOMA." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/dissertations/1031.

Full text

Abstract:

TBX2, a member of the T-box family of transcription factors, plays important roles in embryonic development. Aberrant expression of TBX2 is observed in many cancers, and serves as an oncogene to maintain tumor cell proliferative and malignant properties. We found that TBX2 was expressed in both embryonic myoblasts and adult proliferative satellite cells, but was quickly down regulated during muscle differentiation in mouse models, which suggests an important function of TBX2 in the early myogenesis. Using molecular and cellular biology approaches we showed that TBX2 forms complex with myogenin

APA, Harvard, Vancouver, ISO, and other styles

30

Ianzano, Marianna Lucia <1982&gt. "New molecular approaches to control rhabdomyosarcoma onset and metastasis in preclinical systems." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3765/1/Ianzano_MariannaLucia_tesi.pdf.

Full text

Abstract:

Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. The aim of this study was to identify molecular events involved in rhabdomyosarcoma onset for the development of new therapeutic approaches against specific molecular targets. BALB-p53neu mice develop pelvic rhabdomyosarcoma and combines the activation of HER-2/neu oncogene with the inactivation of an allele of p53 oncosuppressor gene. Gene expression profiling led to the identification of genes potentially involved in rhabdomyosarcoma genesis and therefore of candidate targets. The pattern of expression of p53, HER-2/n

APA, Harvard, Vancouver, ISO, and other styles

31

Ianzano, Marianna Lucia <1982&gt. "New molecular approaches to control rhabdomyosarcoma onset and metastasis in preclinical systems." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3765/.

Full text

Abstract:

Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. The aim of this study was to identify molecular events involved in rhabdomyosarcoma onset for the development of new therapeutic approaches against specific molecular targets. BALB-p53neu mice develop pelvic rhabdomyosarcoma and combines the activation of HER-2/neu oncogene with the inactivation of an allele of p53 oncosuppressor gene. Gene expression profiling led to the identification of genes potentially involved in rhabdomyosarcoma genesis and therefore of candidate targets. The pattern of expression of p53, HER-2/n

APA, Harvard, Vancouver, ISO, and other styles

32

Oh, Teak-Jung. "TBX2 IS REPRESSED BY TBX3 AND TBX3 IS TARGETED BY PRC2 IN RHABDOMYOSARCOMA." OpenSIUC, 2018. https://opensiuc.lib.siu.edu/theses/2393.

Full text

Abstract:

TBX2 and TBX3, which function as repressors, are members of the T-Box transcription factor family which are conserved throughout the metazoan lineage. TBX2 is highly expressed in rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, and many other cancers. Previously, our lab dissected the oncogenic properties of TBX2 and its regulation of p14, p21 and PTEN. TBX3 is also expressed in some cancer types, however, its expression profile in RMS is severely down-regulated. TBX3 is shown to repress TBX2 in chondrocytes, but the characterization and regulation of TBX3 is poorly und

APA, Harvard, Vancouver, ISO, and other styles

33

Rengaswamy, Venkatesh [Verfasser], and Regine [Akademischer Betreuer] Süss. "In vitro and in vivo validation of gene silencing nanoparticles against alveolar rhabdomyosarcoma." Freiburg : Universität, 2015. http://d-nb.info/1125904186/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Khan, Saira. "ROLE OF DEAF-1 IN TRANSCRIPTIONAL REGULATION OF PTEN AND EFFECTS OF DEAF-1 OVEREXPRESSION IN HUMAN RHABDOMYOSARCOMA CELL LINES." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/theses/972.

Full text

Abstract:

Deformed epidermal autoregulatory factor -1 (DEAF-1) is a transcription factor mapping to the chromosomal region 11p15.5, a region associated with loss of heterozygosity (LOH) in human cancers. Potential DEAF-1 binding motifs were identified in the PTEN promoter and the ability of DEAF-1 to regulate PTEN gene expression was investigated. DEAF-1 increased transcription 10-14 fold with PTEN sequences between -429 and -221, while mutations in the DNA binding domain (DEAF-ADWA) and nuclear localization signal of DEAF-1 abolished this increase. DEAF-1 was shown to bind sequences between -339 and -

APA, Harvard, Vancouver, ISO, and other styles

35

Chowdhury, Md Miraj Kobad. "Tyrosyl-DNA phosphodiesterase 1 (Tdp1) : a rhabdomyosarcoma therapy target and mitochondrial DNA repair enzyme." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/40173.

Full text

Abstract:

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs blocked 3´ DNA termini to enable DNA repair. The H493R mutation in TDP1, which disrupts the active site of the enzyme and leads to formation of long-lived TDP1-DNA adducts, causes the progressive neurodegenerative disease spinocerebellar ataxia with axonal neuropathy 1 (SCAN1). Loss of function of TDP1 results in increased sensitivity towards several genotoxic agents including camptothecin analogues, bleomycin and ionizing radiation in vitro and in vivo. In this study, the rationale for using TDP1 as a therapeutic anticancer target and the role of

APA, Harvard, Vancouver, ISO, and other styles

36

Ridzewski, Rosalie [Verfasser], Heidi [Akademischer Betreuer] Hahn, Matthias [Akademischer Betreuer] Dobbelstein, and Dieter [Akademischer Betreuer] Kube. "Improving Therapies of Rhabdomyosarcoma / Rosalie Ridzewski. Betreuer: Heidi Hahn. Gutachter: Matthias Dobbelstein ; Dieter Kube." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1081246855/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Tabarean, Iustin V. "A study of the ion channels expressed in the human rhabdomyosarcoma cell line TE671." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336906.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Ragab, Nada [Verfasser], and Alexander [Akademischer Betreuer] Marx. "Molecular mechanisms of the muscle differentiation blockade in Rhabdomyosarcoma / Nada Ragab ; Betreuer: Alexander Marx." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1233788078/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Magnusson, Sara. "Transcriptome analysis of the sumo cycle enzymes in rhabdomyosarcoma cells : Rhabdomyosacroma and SUMO network." Thesis, Högskolan i Skövde, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18586.

Full text

Abstract:

The Small Ubiquitin-like Modifier (SUMO) moiety is a member of the superfamily of ubiquitin-like proteins (UbLs) including Ubiquitin, Nedd8, FAT10, ISG15 and ATGs. Several proteins are attached by the UbLs through a fine and tuned enzymatic cascade called post-translational modifications (PTM). SUMOylation is the drug-targetable PTM regulated by SUMO and its specific conjugating E1, E2, E3 and deconjugating SENPs enzymes. This PTM regulates several cellular functions, such as cell growth, gene regulation and apoptosis, while deregulation of SUMOylation reaction has been related to promote tumo

APA, Harvard, Vancouver, ISO, and other styles

40

Mohamad, Trefa Salih. "EARLY GROWTH RESPONSE 1 (EGR1) AS A TUMOR SUPPRESSOR AND APOPTOSIS INDUCER IN RHABDOMYOSARCOMA." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1375.

Full text

Abstract:

EGR1, one of the immediate-early response genes, plays an important role as a mediator for transmitting extracellular stimuli. EGR1 is down regulated in many cancers. Many studies show that it functions as a tumor suppressor gene in a variety of cancers. EGR1 also acts as an oncogene in number of cancers. We found that in rhabdomyosarcoma (RMS), which is a muscle derived pediatric cancer, EGR1 was expressed in both RMS subtypes, embryonal and alveolar, but with a much higher expression profile in embryonal RMS. This suggests different mechanisms of down regulation of EGR1 in these two subtypes

APA, Harvard, Vancouver, ISO, and other styles

41

Zhang, Meiling. "MOLECULAR DEFECTS OF MEF2 FAMILY PROTEINS AND NAC PROTEINS THAT BLOCK MYOGENESIS AND PROMOTE TUMORIGENESIS IN RHABDOMYOSARCOMA." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/dissertations/1079.

Full text

Abstract:

Rhabdomyosarcoma (RMS) is a highly malignant pediatric cancer that is the most common form of soft tissue tumors in children. RMS cells have many features of skeletal muscle cells, yet do not differentiate. Thus, our studies have focused on the molecular defects present in these cells that block myogenesis. We have found MEF2D is absent in RMS cell lines representing both major subtypes of RMS and primary cells derived from an embryonal RMS mice model. We have shown that the down regulation of MEF2D is a major cause for the failure of RMS cells to differentiate. We find MEF2D cannot bind to mu

APA, Harvard, Vancouver, ISO, and other styles

42

Dumont, Sarah. "Caractéristiques cliniques, moléculaires et prise en charge des Rhabdomyosarcomes de l'adulte et identification d'une polythérapie ciblée in vitro." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10311/document.

Full text

Abstract:

Le rhabdomyosarcome de l'adulte est une tumeur rare au pronostic. Le présent travail propose d'étudier les caractéristiques cliniques et moléculaires et la prise en charge des adolescents et adultes atteints de rhabdomyosarcome ainsi que la possibilité de combinaison de thérapie ciblées sur lignées cellulaires in vitro. Nous avons anamysé rétrospectivement 239 patients âgés de 10 ans ou plus, atteints de rhabdomyosarcome au MD Anderson Cancer Center entre 1957 et 2003 et leur statut fusionnel pour PAX-FOXO1 par hybridation in situ en fluorescence. Trois lignées cellulaire de sarcome à petites

APA, Harvard, Vancouver, ISO, and other styles

43

Loo, Tenneille. "The pharmacogenomics of vincristine-induced neurotoxicity in paediatric cancer patients with Wilms tumor or rhabdomyosarcoma." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36635.

Full text

Abstract:

Vincristine is one of the most effective and widely utilized antineoplastic agents. However, the clinical utility of this drug is limited by severely debilitating vincristineinduced neurotoxicities (VIN). Previous studies have associated VIN with genetic polymorphisms in genes involved in the metabolism and transportation of vincristine, including CYP3A4, CYP3A5, and ABCB1. However, the findings of such studies have not been consistently reproduced. This study hypothesizes that there are specific variants in genes involved in general drug absorption, metabolism, distribution, excretion, and to

APA, Harvard, Vancouver, ISO, and other styles

44

Singh, Ravi K. "Molecular Determinants of Alternative Splicing of MDM2 in Response to Stress: Implications in Pediatric Rhabdomyosarcoma." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1250624309.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Saggioro, Mattia. "Alveolar Rhabdomyosarcoma 3D model development to mimic physiological cell-ECM interactions with focus on integrins." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3422703.

Full text

Abstract:

Introduction: Rhabdomyosarcoma (RMS) is the most common Soft Tissue Sarcoma in childhood, the two main subtypes are embryonal RMS (ERMS), associated with a better prognosis, and alveolar RMS (ARMS), more aggressive and highly metastatic. If the knowledge of RMS genomic alterations is well established, its microenvironmental characterization is still poorly defined. So far, in vitro 2D models are used to recapitulate the interactions between cancer cells and stromal cells. However, these models are not representative of the complex biological processes that happen in vivo, such as cell migrati

APA, Harvard, Vancouver, ISO, and other styles

46

Shah, Nupur R. "Functional studies of YAP1 in cancer and embryonic development." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238733.

Full text

Abstract:

The Hippo pathway is a master regulator of cell proliferation and organ size, namely through regulation of transcriptional co-activators YAP and TAZ which bind TEAD1-4 transcription factors. The Hippo effector YAP is dysregulated in many human solid tumours including rhabdomyosarcoma and oesophageal cancer. Additionally, persistent hyperactivity of YAP in activated but not quiescent satellite cells can give rise to embryonal rhabdomyosarcoma. However, the question of exactly how YAP acts as an oncogene and actively gives rise to tumour progression in these cancers remains unknown. In this thes

APA, Harvard, Vancouver, ISO, and other styles

47

Milewski, David E. "Forkhead Box F1 (FOXF1) is an essential effector of the PAX3/FOXO1 oncogene in human alveolar rhabdomyosarcoma." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563295140262318.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Almazán, Moga Ana. "Caracterización del mecanismo de activación de la vía Hedgehog en el rabdomiosarcoma: el papel oncogénico de los ligandos." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399995.

Full text

Abstract:

El rabdomiosarcoma (RMS) es el sarcoma de partes blandas más común en la infancia y se considera que se origina en células embrionarias destinadas a la formación de músculo esquelético. Histológicamente, el RMS se divide en 2 grupos principales: embrionario (RMSe) y alveolar (RMSa), los cuales difieren tanto en su presentación clínica, respuesta a terapia y pronóstico, siendo el subtipo alveolar el que presenta un pronóstico más desfavorable. La vía de señalización Hedgehog (HH) tiene un papel clave en el desarrollo y la progresión de muchos tipos de cáncer, incluyendo el RMS. Aunque esté am

APA, Harvard, Vancouver, ISO, and other styles

49

Wang, Weiguang. "The study of the oncogenic effect of PAC3, PAX3-FKHR and IGF-II genes in rhabdomyosarcoma and medulloblastoma." Thesis, Manchester Metropolitan University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243719.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Alanisi, Entkhab. "RHABDOMYOSARCOMA 2 ASSOCIATED TRANSCRIPT (RMST) AS A NEGATIVE REGULATOR OF MAMMALIAN TARGET OF RAPAMYCIN (MTOR) IN CANCER CELLS." OpenSIUC, 2019. https://opensiuc.lib.siu.edu/dissertations/1740.

Full text

Abstract:

Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides that do not code for known proteins. These lncRNAs were originally thought as non-functional. However, loss and/or gain-of-function studies of these transcripts suggest that lncRNAs have crucial roles in many biological functions like apoptosis, cell cycle, translation control, epigenetic regulation, splicing regulation and many other processes in the cells. Lovastatin is a FDA-approved drug for treatment of hypercholesterolemia. Lovastatin can cause apoptosis in a number of tumor cells, but the mechanisms remain poorly

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!