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Journal articles on the topic 'Rhabdomyosarcoma'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Manzoor, Mohammad, Bismah Ahmad, Adnan Sarwar, et al. "Epidemiological And Histopathologic Study Of Rhabdomyosarcoma cases in a tertiary Care hospital of Peshawar." Pakistan BioMedical Journal 4, no. 2 (2021): 292–96. http://dx.doi.org/10.54393/pbmj.v4i2.253.

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 Aim: This study aimed to find out rhabdomyosarcoma’s (RMS) histopathological and immunohistochemical features. Settings: The current study was carried out at the Department of Pathology, Section of Histopathology, Khyber Teaching Hospital Peshawar. The study duration was between from 1st January 2015 to 30th of December 2020. Results: In the current study, all the 300 occurrences were found to be relevant. The most prevalent rhabdomyosarcoma was embryonal rhabdomyosarcoma (ERMS) (87.4%), followed by alveolar rhabdomyosarcoma (ARMS) (9.4%). In the current study we found that embryonal rh

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2

Rekhi, Bharat, Pawan Upadhyay, Manoj P. Ramteke, and Amit Dutt. "MYOD1 (L122R) mutations are associated with spindle cell and sclerosing rhabdomyosarcomas with aggressive clinical outcomes." Modern Pathology 29, no. 12 (2016): 1532–40. http://dx.doi.org/10.1038/modpathol.2016.144.

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Abstract Recurrent mutations in the myogenic transcription factor MYOD1 and PIK3CA were initially described in a subset of embryonal rhabdomyosarcomas. Recently, two independent studies demonstrated presence of MYODI (L122R) mutations as the basis to re-classify a spindle cell rhabdomyosarcoma, along with a sclerosing rhabdomyosarcoma, distinct from an embryonal rhabdomyosarcoma. We analyzed a much larger cohort of 49 primary rhabdomyosarcoma tumor samples of various subtypes, collected over a period of 9 years, for the presence of MYOD1 (L122R), PIK3CA (H1047), and PIK3CA (E542/E545) mutation

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Şahan, Mehmet Hamdi, Şeyma Eseoğlu, and Melih Akşamoğlu. "A rare case of primary pulmonary embryonal rhabdomyosarcoma in children." Surgery on Children 2, no. 1 (2025): 33–35. https://doi.org/10.51271/soc-0031.

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Rhabdomyosarcoma is one of the most common soft tissue sarcomas in adolescence and young adults. Histologically, rhabdomyosarcoma has many subgroups, including embryonal, alveolar, pleomorphic, and spindle cell/sclerosing rhabdomyosarcomas. More than 50% of embryonal rhabdomyosarcomas occur in the head and neck region. The retroperitoneum and pelvis are less common sites of involvement. Primary pulmonary embryonal rhabdomyosarcoma is extremely rare. A 3-year-old girl presented with symptoms of cough and shortness of breath. A mass lesion with regular contours, approximately 3x3 cm in size, con

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Roldan, Rodante A., Erasmo Gonzalo DV Llanes, and Romeo L. Villarta. "Embryonal Rhabdomyosarcoma of the Mandible." Philippine Journal of Otolaryngology-Head and Neck Surgery 21, no. 1-2 (2005): 36–38. http://dx.doi.org/10.32412/pjohns.v21i1-2.831.

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Objectives: 1] To describe a case of an embryonal rhabdomyosarcoma presenting as a radiolucent mandibular mass in a 3-year-old child. 2] To review existing literature on the clinical picture and pathophysiology of intraosseous rhabdomyosarcoma. 3] To identify learning points in the diagnosis of intraosseous rhabdomyosarcoma.  Design: Case report.  Setting: A tertiary referral hospital.  Patients: One (1)  Results: A case of a 3-year-old child with a radiolucent mandibular mass is described. The final histopathologic report turned out to be embryo

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5

Abraham, Jinu, Laura D. Nelon, Courtney B. Kubicek, et al. "Preclinical Testing of Erlotinib in a Transgenic Alveolar Rhabdomyosarcoma Mouse Model." Sarcoma 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/130484.

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Rhabdomyosarcoma is an aggressive childhood malignancy, accounting for more than 50% of all soft-tissue sarcomas in children. Even with extensive therapy, the survival rate among alveolar rhabdomyosarcoma patients with advanced disease is only 20%. The receptor tyrosine kinase Epidermal Growth Factor Receptor (EGFR) has been found to be expressed and activated in human rhabdomyosarcomas. In this study we have used a genetically engineered mouse model for alveolar rhabdomyosarcoma (ARMS) which faithfully recapitulates the human disease by activating the pathognomic Pax3:Fkhr fusion gene and ina

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Mccluggage, W. G., T. F. Lioe, H. R. Mcclelland, and H. Lamki. "Rhabdomyosarcoma of the uterus: Report of two cases, including one of the spindle cell variant." International Journal of Gynecologic Cancer 12, no. 1 (2002): 128–32. http://dx.doi.org/10.1136/ijgc-00009577-200201000-00021.

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Abstract.McCluggage WG, Lioe TF, McClelland HR, Lamki H. Rhabdomyosarcoma of the uterus: Report of two cases, including one of the spindle cell variant.Most uterine sarcomas fall into the category of leiomyosarcoma, endometrial stromal sarcoma, or undifferentiated sarcoma. Pure rhabdomyosarcomas are extremely rare, although a rhabdomyosarcomatous element may be present as a component of an adenosarcoma or carcinosarcoma (malignant mixed müllerian tumor). This report describes two uterine rhabdomyosarcomas in 28- and 67-year-old women. These were of spindle cell and pleomorphic types, respectiv

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7

Sinha, Kavita, Home Nath Adhikari, and Pooja Baidya. "Uterine Cervix Rhabdomyosarcoma : A Case Report." Journal of Nepalgunj Medical College 21, no. 2 (2023): 46–48. http://dx.doi.org/10.3126/jngmc.v21i2.62809.

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Rhabdomyosarcoma is a malignant tumor that arises from embryonal skeletal muscle cells. It is responsible for 3% of cancer cases among children aged from 0 to 14 and 1% among adolescent and young adult aged from 15 to 19. Embryonal Rhabdomyosarcoma is the most prevalent subtype in the female genital tract and Botryoid sarcomas being a polypoid variant. In young patients, the majority of genital tract rhabdomyosarcomas occur in vagina; however, the most common site being cervix followed by uterine corpus, in adults. We hereby report a case of 24 years lady P2L2 diagnosed as Botryoid Embryonal R

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8

Al-Mubarak, Luluah, and Sultan Al-Khenaizan. "A Wolf in Sheep's Disguise: Rhabdomyosarcoma Misdiagnosed as Infantile Hemangioma." Journal of Cutaneous Medicine and Surgery 13, no. 5 (2009): 276–79. http://dx.doi.org/10.2310/7750.2009.08048.

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Background: Rhabdomyosarcomas are a heterogeneous group of malignant tumors representing the most common soft tissue sarcoma of childhood. A delay in diagnosis is not uncommon. Objective: To report a boy with paranasal rhabdomyosarcoma who was misdiagnosed and treated for infantile hemangioma. Methods and Results: A 2-year-old Saudi boy who presented with a progressively increasing nasal mass for 18 months was misdiagnosed and treated for infantile hemangioma at an outside hospital. Histopathologic examination revealed paranasal rhabdomyosarcoma. Conclusion: We review some clinical clues that

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9

Marzouk, Sawssen Ben, Wael Ferjaoui, Adel Jelassi, Nizar Cherni, Mohamed Hedi Mannai, and Mohamed Bechir Khalifa. "Rhabdomyosarcoma of the Buttock, Rare Location." Clinical Case Reports and Studies 3, no. 3 (2023): 1–2. http://dx.doi.org/10.59657/2837-2565.brs.23.070.

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Rhabdomyosarcoma is a common mesenchymal tumor in children. it is a rare tumor in adults and exceptional in the elderly. The most frequent locations of rhabdomyosarcomas are the head, neck, orbit and urinary tract, these locations are considered favorable. Other locations are considered unfavorable. We report the case of cutaneous rhabdomyosarcoma of the buttock in a 61-year-old man operated on at our service.

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Vadgama, Bhumita, Neil James Sebire, Marian Malone, and Alan Drummond Ramsay. "Sclerosing Rhabdomyosarcoma in Childhood: Case Report and Review of the Literature." Pediatric and Developmental Pathology 7, no. 4 (2004): 391–96. http://dx.doi.org/10.1007/s10024-003-9453-5.

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Rhabdomyosarcoma is the most common soft tissue malignancy in children but is rare in adults. The latest World Health Organization classification of soft tissue tumors recognizes embryonal, alveolar, and pleomorphic rhabdomyosarcomas. More recently, a sclerosing variant of rhabdomyosarcoma has been recognized and reported in seven adult patients. We describe a pediatric case of sclerosing rhabdomyosarcoma presenting as a sacral mass in a 3-year-old girl. Morphologically, the tumor showed a prominent sclerosing hyaline matrix and demonstrated pseudovascular and microalveolar architectural foci.

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Narayana Kurup, Jayakrishnan K., Vinay C. Kamble, Ashwath M. Acharya, and Anil K. Bhat. "Massive Embryonal Rhabdomyosarcoma of the Hand in an Infant With Metastasis at Birth: Management Dilemma." HAND 12, no. 5 (2017): NP109—NP112. http://dx.doi.org/10.1177/1558944716685827.

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Background: Rhabdomyosarcomas are malignant tumors arising from striated muscle but can be often confused with primitive neuroectodermal tumors and Ewing sarcoma. They are often classified based on age of presentation and histological features. Three major types of rhabdomyosarcomas are embryonal, alveolar, and pleomorphic with characteristic presentations. Method: Here, we present a case of embryonal rhabdomyosarcoma in the hand of a 5-month-old child with lymphatic metastasis, the age, site, and metastasis being unusual feature for this type of rhabdomyosarcoma. Result: The child succumbed t

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Chen, Zihang, Xing-yu Li, Peng Guo, and Dong-lai Wang. "MYBPC2 and MYL1 as Significant Gene Markers for Rhabdomyosarcoma." Technology in Cancer Research & Treatment 20 (January 1, 2021): 153303382097966. http://dx.doi.org/10.1177/1533033820979669.

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Background: Rhabdomyosarcoma is the most common soft tissue tumor in children. Rhabdomyosarcoma commonly results in pain and bleeding caused by tumor compression and is prone to early metastasis and recurrence, which can seriously affect the therapeutic outcomes and long-term prognosis. Up to 37.7% of rhabdomyosarcomas may metastasize. Therefore, the molecular mechanisms underlying rhabdomyosarcoma must be explored to identify an effective target for its early diagnosis and specific treatment. Methods: A dataset of 18 rhabdomyosarcoma tissue samples and 6 healthy skeletal muscle samples was do

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13

Vegari, Saman, Alireza Hemati, Hosein Baybordi, Leila Davarimajd, and Ghasem Chatrbahr. "Embryonal Rhabdomyosarcoma in Mastoid and Middle Ear in a 3-Year-Old Girl: A Rare Case Report." Case Reports in Otolaryngology 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/871235.

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Introduction. The most common sarcoma of childhood is rhabdomyosarcoma, approximately 35% of all paediatric rhabdomyosarcomas occur in the head and neck.Case Report. A 3-year-old girl referred to our clinic due to serosanguineous purulent discharge from her right ear. After paraclinical and pathologic evaluation it was diagnosed as embryonic rhabdomyosarcoma.Conclusions. In all children with mastoiditis, especially in young children, rhabdomyosarcoma should be considered as a differential diagnosis.

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Parham, David M., and Dale A. Ellison. "Rhabdomyosarcomas in Adults and Children: An Update." Archives of Pathology & Laboratory Medicine 130, no. 10 (2006): 1454–65. http://dx.doi.org/10.5858/2006-130-1454-riaaca.

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Abstract Context.—Rhabdomyosarcomas comprise a relatively common diagnostic entity among childhood cancers and a relatively rare one among adult tumors. They may possess a variety of histologies that generally differ among age groups. These lesions appear to be separate biologic entities as well as morphologic categories, with embryonal tumors having genetic lesions related to loss of heterozygosity and aberrant parental imprinting, alveolar tumors containing genetic fusions between PAX and forkhead genes, and pleomorphic tumors showing an accumulation of genetic lesions similar to other adult

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15

Sánchez-Montenegro, Carlos, Alejandra Vilanova-Sánchez, Saturnino Barrena-Delfa, et al. "Costello Syndrome and Umbilical Ligament Rhabdomyosarcoma in Two Pediatric Patients: Case Reports and Review of the Literature." Case Reports in Genetics 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/1587610.

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Costello syndrome is caused by heterozygous de novo missense mutations in the protooncogene HRAS with tumor predisposition, especially rhabdomyosarcoma. We here report two pediatric patients with Costello syndrome and umbilical ligament rhabdomyosarcoma. A review of the literature published in English in MEDLINE from January 1971 to June 2016 using the search terms “Costello syndrome” and “rhabdomyosarcoma” was performed, including two new cases that we describe. Twenty-six patients with Costello syndrome and rhabdomyosarcoma were recorded with mean age of diagnosis of 2 years and 8 months. Th

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S, Outaghyame, Garmane A, Zouita I, Basraoui D, and Jalal H. "Bladder Rhabdomyosarcoma: A Case Report." Scholars Journal of Medical Case Reports 11, no. 06 (2023): 1188–90. http://dx.doi.org/10.36347/sjmcr.2023.v11i06.037.

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Tumors of the urogenital sinus in children are very rare. Rhabdomyosarcoma is the most common tumor. In girls, it includes tumors of the uterus, vagina, cervix, vulva and bladder. Rhabdomyosarcomas account for 8℅ of all pediatric malignancies. Rhabdomyosarcoma of the bladder is a rare condition. We report an observation of a bladder rhabdomyosarcoma in a one-year-old girl, who consulted for hematuria with impaired renal function. The aim of this paper is to review the clinical symptomatology and radiological appearance of this condition in children, following a literature review of the conditi

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Damjanovic, Miodrag, Miloje Tomasevic, Danijela Djordevic-Radojkovic, Goran Koracevic, and Ruzica Jankovic. "Cardiac rhabdomyosarcoma." Vojnosanitetski pregled 64, no. 5 (2007): 353–56. http://dx.doi.org/10.2298/vsp0705353d.

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Background. Primary malignant cardiac tumors are rare entities and rhabdomyosarcoma accounts 20% of these lesions. Case report. We presented a female patient with loss of appetite and loss of weight. She also had symptoms of heart failure and bilateral pleural effusions. A mobile tumor in the left heart with the entrance from the left atrium to left ventricle during diastole was seen by transthoracic echocardiography. The tumor was extirpated in total, histologic diagnosis was rhabdomyosarcoma, and the patient died after 6 months. Conclusion. Primary malignant cardiac tumors can simulate heart

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Razafimanjato, Narindra Njarasoa Mihaja, Tsiry Dama Ntsoa Ravelomihary, Mampionona Ranaivomanana, Guillaume Odilon Tsiambanizafy, Hanitrala Jean Louis Rakotovao, and Francis Allen Hunald. "Surgical approach and prognosis of primitive chest wall alveolar rhabdomyosarcoma in an adult: A case report and review of the literature." Journal of Clinical and Investigative Surgery 5, no. 2 (2020): 104–8. http://dx.doi.org/10.25083/2559.5555/5.2/104.108.

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Alveolar rhabdomyosarcomas (ARMS) are rare entities that occur predominantly on the extremities and represent 20% of rhabdomyosarcomas. Other common locations include the peri-rectal and perineal regions, head and neck, and genitourinary system. To our knowledge, this presentation is the first case of alveolar rhabdomyosarcoma of the chest wall reported in the literature. Here, we describe a case of a 64-year-old man with alveolar rhabdomyosarcomas who underwent a chest wall resection. The defect was reconstructed with polypropylene mesh and latissimus dorsi muscle. Our patient did not show re

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Medeiros, Cleverson Winston de Liz, William Kondo, Ivo Baptista Júnior, Alvo Orlando Vizzotto Júnior, Lúcia de Noronha, and Calixto Antonio Hakim Neto. "Primary rhabdomyosarcoma of the diaphragm: case report and literature review." Revista do Hospital das Clínicas 57, no. 2 (2002): 67–72. http://dx.doi.org/10.1590/s0041-87812002000200004.

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The authors report a case of primary rhabdomyosarcoma of the diaphragm, an extremely rare presentation with only 14 cases reported in the literature. An 18-year-old male presented 2 spontaneous occurrences of pneumothorax. Computed tomography and magnetic resonance showed a tumoral mass on the right diaphragmatic surface, and after biopsy, the diagnosis was compatible with spindle cell rhabdomyosarcoma. Because the visceral pleura was invaded by the tumoral mass, a right pleuropneumonectomy was performed. The patient received adjuvant chemotherapy, and there was no evidence of disease 15 month

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Castleman, W. L., D. E. Toplon, C. K. Clark, et al. "Rhabdomyosarcoma in 8 Horses." Veterinary Pathology 48, no. 6 (2011): 1144–50. http://dx.doi.org/10.1177/0300985810395785.

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This multi-institutional report describes 8 cases of rhabdomyosarcoma in horses. Four neoplasms were in the tongue and other areas of the mouth or head, 2 were in the abdominal wall, and 1 each was in right shoulder muscles and heart. Four rhabdomyosarcomas that were less than 10 cm in diameter were treated by surgical excision or radiation with no recurrence. Two neoplasms greater than 10 cm in diameter in the abdominal wall and the right shoulder were considered inoperable and led to decisions to euthanize the horses. Two neoplasms were incidental findings at necropsy. All the neoplasms were

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Kim, D. Y., E. C. Hodgin, D. Y. Cho, and J. E. Varnado. "Juvenile Rhabdomyosarcomas in Two Dogs." Veterinary Pathology 33, no. 4 (1996): 447–50. http://dx.doi.org/10.1177/030098589603300416.

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Juvenile rhabdomyosarcomas were diagnosed in two young dogs based on the results of histopathology, phosphotungstic acid-hematoxylin stain, immunohistochemistry, and the age of the dogs. One dog, an 11-month-old Rottweiler, had tumor masses in the maxillary gingiva and the urinary bladder. Histologically, the gingival mass was an alveolar type of rhabdomyosarcoma and the urinary bladder mass was an embryonal type. The other dog, a 1.5-year-old Basset Hound, had an embryonal rhabdomyosarcoma involving the oropharynx and the temporal muscles, with metastasis to the regional lymph node and lungs.

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Kanta Ka, Lissoune Cissé, Oumar Gaye, et al. "Rhabdomyosarcoma of the prostate in children: A Case Report." World Journal of Advanced Research and Reviews 11, no. 3 (2021): 312–15. http://dx.doi.org/10.30574/wjarr.2021.11.3.0475.

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Context: The therapeutic transition from mutilating surgery to external radiotherapy followed by brachytherapy is increasingly effective in the treatment of rhabdomyosarcoma. Case presentation: 13-year-old child with no medical and surgical history, received for complete urine retention. Imaging examinations revealed a prostatic mass of 6 cm. The anatomopathological examination reveals an embryonic rhabdomyosarcoma. There was no recurrence after 3 years of follow-up after a multimodal treatment combining chemotherapy, external radiotherapy and high dose interstitial brachytherapy. Conclusion:

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Temtem, Tsega. "Biliary botryoid rhabdomyosarcoma in a pediatric patient." Journal of Pediatrics & Neonatal Care 9, no. 5 (2019): 121–23. http://dx.doi.org/10.15406/jpnc.2019.09.00391.

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Biliary rhabdomyosarcomas are rare, making up about 1% of all liver malignancies. These tumors are often an embryonal subtype and generally large, measuring multiple centimeters. We present an 11-year-old female with a history of intermittent painless jaundice and imaging suspicious for a choledochal cyst. Endoscopy identified a lesion protruding from her ampulla, and pathology diagnostic of a botryoid variant of embryonal rhabdomyosarcoma. She improved with chemotherapy and radiation. Botryoid biliary rhabdomyosarcomas typically have rapid growth with early presentation of jaundice around 3.5

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Yenli, Edwin M. T., Kingsley A. Bimpong, Nihad Salifu, et al. "Infant Bladder Rhabdomyosarcoma in a Shared-Care Centre in Ghana: Case Report and Review of the Literature." International Journal of Innovative Research in Medical Science 6, no. 05 (2021): 351–55. http://dx.doi.org/10.23958/ijirms/vol06-i05/1122.

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Rhabdomyosarcoma is a fairly common soft tissue sarcoma among children. Genitourinary rhabdomyosarcoma accounts for one tenth of rhabdomyosarcomas in the West African sub-region. However, its occurrence and management are yet to be reported in our resource limited study setting. Care of such patients could be a daunting task. A comprehensive paediatric oncology service should be advocated to optimize the chances of survival. A seven-month old boy was referred to our facility on account of posterior urethral valve. A week’s complaint of crying on micturition, with associated passage of scanty u

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Arnaldez, Fernanda Irene, Choh L. Yeung, Carly J. Smith, Natasha Caplen, and Lee J. Helman. "Identification of TNK2 as a critical kinase in rhabdomyosarcoma through a loss of function shRNA screen." Journal of Clinical Oncology 30, no. 15_suppl (2012): 9511. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.9511.

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9511 Background: Rhabdomyosarcoma is the most common pediatric soft tissue sarcoma. Embryonal rhabdomyosarcomas (ERMS) are characterized by 11p15 LOH while alveolar rhabdomyosarcomas harbor a translocation between PAX3 or PAX7 and FOXO1. Relapsed or metastatic disease has a 5-year survival rate of 25%. Methods: We sought to identify critical genes for rhabdomyosarcoma cell growth and survival. We performed a loss-of-function shRNA screen where a library of 15,000 shRNAs was introduced in RH30 (ARMS) and RD (ERMS) cells engineered to express the bacterial tetracycline repressor in a tet-on syst

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Kanta, Ka, Cissé Lissoune, Gaye Oumar, et al. "Rhabdomyosarcoma of the prostate in children: A Case Report." World Journal of Advanced Research and Reviews 11, no. 3 (2021): 312–15. https://doi.org/10.5281/zenodo.5560211.

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<strong>Context:</strong> The therapeutic transition from mutilating surgery to external radiotherapy followed by brachytherapy is increasingly effective in the treatment of rhabdomyosarcoma. <strong>Case presentation:</strong> 13-year-old child with no medical and surgical history, received for complete urine retention. Imaging examinations revealed a prostatic mass of 6 cm. The anatomopathological examination reveals an embryonic rhabdomyosarcoma. There was no recurrence after 3 years of follow-up after a multimodal treatment combining chemotherapy, external radiotherapy and high d

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Xu, Fushen, Luis E. De Las Casas, and Larry J. Dobbs. "Primary Meningeal Rhabdomyosarcoma in a Child With Hypomelanosis of Ito." Archives of Pathology & Laboratory Medicine 124, no. 5 (2000): 762–65. http://dx.doi.org/10.5858/2000-124-0762-pmriac.

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Abstract Intracranial rhabdomyosarcomas are rare neoplasms, and those thought to be primary meningeal tumors are even more rare. Hypomelanosis of Ito is a neurocutaneous disorder believed to involve a defect in cells of neural crest origin. We report the case of a 15-month-old boy with hypomelanosis of Ito who developed a primary meningeal rhabdomyosarcoma. The patient initially presented with hydrocephalus and 2 months later developed neurologic signs localizing to the spinal cord. Radiologic studies revealed widespread leptomeningeal enhancement with compression of the spinal cord at C5-C7.

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EL-Ghazali, A. M. S., and K. M. McLaren. "Embryonal rhabdomyosarcoma of adult nasopharynx." Journal of Laryngology & Otology 119, no. 8 (2005): 639–42. http://dx.doi.org/10.1258/0022215054516142.

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Adult rhabdomyosarcomas in the head and neck are extremely rare and carry a poor prognosis. They should be considered as a distinct clinical entity. The authors report a case of embryonal rhabdomyosarcoma in an adult nasopharynx treated with a combined modality treatment of chemotherapy and radiotherapy as per the European International Society of Paediatric Oncology (SIOP) MMT 89 study, group D. The patient responded to treatment and 10 years later, he is still alive with no signs of metastatic disease.

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Miller, Andrew D., Michele Steffey, Ana Alcaraz, and Barry Cooper. "Embryonal Rhabdomyosarcoma in a Young Maine Coon Cat." Journal of the American Animal Hospital Association 45, no. 1 (2009): 43–47. http://dx.doi.org/10.5326/0450043.

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Embryonal rhabdomyosarcomas are uncommon tumors in all domestic species, especially cats. A 14-month-old Maine coon was diagnosed with an embryonal rhabdomyosarcoma in the rectus abdominus muscle, which was treated with complete surgical excision. Although no clinical progression was noted after surgery, the cat succumbed to pulmonary metastasis within 7 months. The histological diagnosis was embryonal rhabdomyosarcoma (myotubular subtype). This category of striated muscle tumors is thought to have a more aggressive clinical course. The rapid demise of this cat even with no clinical or histolo

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Wertz, Aileen, Brittny Tillman, Jennifer Brinkmeier, et al. "Minimally Invasive Approach for Resection of Parameningeal Rhabdomyosarcoma." Journal of Neurological Surgery Part B: Skull Base 38, no. 03 (2016): 210–14. http://dx.doi.org/10.1055/s-0036-1597279.

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Background About one-third of rhabdomyosarcomas arise in the head and neck, with parameningeal primaries accounting for half of these. Principles of management involve chemotherapy, radiation, or both, in addition to surgical biopsy, debulking, and complete or near-complete resection. In the head and neck, diagnostic biopsies have historically been performed without attempt at resection due to proximity to critical structures and cosmetic considerations. Methods Retrospective chart review of three cases of rhabdomyosarcoma at the cranial base managed through minimally invasive endoscopic surgi

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Anugrah, Diko, and Ludy Dhyani Rahmartani. "SDPS-06 A 4 YEAR-OLD GIRL WITH EMBRYONAL RHABDOMYOSARCOMA IN RETROAURICULAR AND MIDDLE EAR : A RARE CASE REPORT FROM INDONESIA." Neuro-Oncology Advances 5, Supplement_3 (2023): iii18. http://dx.doi.org/10.1093/noajnl/vdad070.067.

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Abstract Rhabdomyosarcoma is the most common sarcoma of childhood, and this tumor is the third most common neoplasm after neuroblastoma and nephroblastoma. Rhabdomyosarcomas may originate in any anatomical site, occurring predominantly in head and neck regions, orbits, skull base, nasal cavity, and nasopharynx, where there is little or no musculoskeletal tissue. The involvement of the ear and mastoid bone in rhabdomyosarcoma is uncommon. The embryonal rhabdomyosarcoma includes about 60– 70% of rhabdomyosarcoma cases. A four years-old girl presented with pain in neck and difficult to moving, th

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Fernandes, Hilda, Netheya Mary Thomas, and Anush Serrao. "Intratesticular Rhabdomyosarcoma- A Rare Childhood Tumour." Annals of Pathology and Laboratory Medicine 9, no. 3 (2022): C24–27. http://dx.doi.org/10.21276/apalm.3137.

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Primary malignant of tumours of the testis are rare in children. Tumours of germ cell origin account for 60-77% of primary testicular tumors. Intrascrotal tumours of nongerm cell origin are rare. Rhabdomyosarcomas (RMS) are the commonest tumours among nongerm cell tumours. RMS are more commonly seen in paratesticular region. Pure testicular RMS are rare. A 16 yr boy was evaluated right sided testicular mass. Histopathology and immunohistochemistry confirmed it to be an anaplastic embryonal rhabdomyosarcoma. Here we report this case with a brief review of literature.

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Johanna, Caryl Augustine, and Gede Budhi Setiawan. "Retromolar Embryonal Rhabdomyosarcoma: A Case Report." JBN (Jurnal Bedah Nasional) 1, no. 2 (2017): 47. http://dx.doi.org/10.24843/jbn.2017.v01.i02.p03.

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Background: embryonal rhabdomyosarcoma is common of rhabdomyosarcoma, usually in 5 years old child. Approximately 28% of embryonal rhabdomyosarcomas occur in head and neck area, and 0.04% of cases occur as intra-oral tumors. Case: a 13 years old female complained of a firm and painless progressive mass in her right mandibular retromolar 6 months prior to her current medical check-up. There was a reddish 8x5 cm mass on the right posterior mandibular region. Mid face CT scan showed a well-bordered solid mass in her right oral cavity expanding to the right maxilla without bone destruction nor int

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Zoghi, Shervin, Aaron Tsumura, Rashmi Verma, and Morgan Angus Darrow. "High-Grade Metastatic Pleomorphic Rhabdomyosarcoma in a TP53 Germline Mutation Patient: A Rare Presentation in Adults." Journal of Clinical Case Studies Reviews & Reports 6, no. 3 (2024): 1–3. http://dx.doi.org/10.47363/jccsr/2024(6)274.

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Pleomorphic Rhabdomyosarcomas (PRMS) in adults are an exceptionally rare and aggressive soft-tissue tumor arising from undifferentiated mesenchymal cells. While more common in children, rhabdomyosarcomas in adults are associated with poorer outcomes and require immediate, aggressive intervention. Here we present a case of high-grade pleomorphic rhabdomyosarcoma of the left thigh in a 58-year-old male with metastases to the lungs and pelvis. Due to the limited diagnostic and treatment protocols of this rare disease and subtype, the goal of this case study is to highlight a comprehensive clinica

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Benmessaoud, H., H. Ahmut, H. Bouhia, et al. "MULTIMODAL TREATMENT IN PEDIATRIC ORBITAL RHABDOMYOSARCOMA: ABOUT 8 CASES." International Journal of Advanced Research 11, no. 01 (2023): 1380–82. http://dx.doi.org/10.21474/ijar01/16152.

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Rhabdomyosarcoma is the most frequent mesenchymal tumor in children, composed of cells with histopathological characteristics of striated muscle at different stages of embryogenesis. The orbital location accounts for about 10% of cases. Its prognosis has improved thanks to the progress of chemotherapy and new radiotherapy techniques.The aim of our study is to report the clinical and therapeutic characteristics of rhabdomyosarcomas of the orbit in children, and to present different complications of the treatment.

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Gill, Sukhmani Kaur, Mark Moroz, Jasika Grover, et al. "Analysis of demographic and socioeconomic factors in mixed type rhabdomyosarcoma using NCDB." Journal of Clinical Oncology 42, no. 16_suppl (2024): e23538-e23538. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e23538.

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e23538 Background: Mixed type rhabdomyosarcoma is a rare soft tissue tumor characterized by the presence of two histologically different subtypes of rhabdomyosarcoma, commonly found in the testis. Despite a majority of the patients undergoing aggressive treatment, the prognosis is poor. Analysis of its diagnostic trends could prove valuable in understanding mixed type rhabdomyosarcoma’s epidemiology. The 2004-2020 National Cancer Database (NCDB) was analyzed to determine the demographic factors of patients with mixed type rhabdomyosarcoma. Methods: A retrospective cohort analysis of the 2004–2

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Chehrastane, Rachida, Ihssan Hadj Hsain, Fatima Chait, et al. "Pediatric Nasopharyngeal Rhabdomyosarcoma: A Case Report." Asian Journal of Pediatric Research 14, no. 6 (2024): 94–99. http://dx.doi.org/10.9734/ajpr/2024/v14i6358.

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Rhabdomyosarcomas is a soft tissue tumor with a highly invasive malignant cells that originate of the skeletal muscle cells, specially occurs in the head and neck regions, the presentation in the parameningeal region, including the paranasal sinuses and nasal cavity, the presentation in the nasopharynx is infrequent. The diagnosis is confirmed by appropriate immunohistochemical stains, while conventional radiology is used for evaluating the primary tumor, determining the extension to nearby organs, and detecting any potential metastases. The treatment of nasal rhabdomyosarcoma is a real challe

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BRELLOU (Γ.Δ. ΜΠΡΕΛΛΟΥ), G. D., V. PSYCHAS (Β. ΨΥΧΑΣ), and I. VLEMMAS (Ι. ΒΛΕΜΜΑΣ). "Rhabdomyosarcomas arising from striated muscles in elderly dogs: pathological features of 4 cases." Journal of the Hellenic Veterinary Medical Society 64, no. 2 (2017): 105. http://dx.doi.org/10.12681/jhvms.15483.

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Primary rhabdomyosarcomas are rare in dogs. Based on their classification, embryonal rhabdomyosarcoma is the most common, while alveolar and especially pleomorphic types occur less often. Four cases diagnosed as primary canine rhabdomyosarcomas of striated muscles were retrieved from our files. All the animals were cross-breeds, aged over 8 years. Two of them had died after developing disseminated intravascular coagulation and gastric ulcer, respectively, and two others were euthanized. Of those two, one had been admitted with neurological and cardiovascular symptoms and one with disseminated

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Das, Ananya, Subrat Panda, Anusuya Sarma, and Biswajit Dey. "A Rare Report of Vaginal Rhabdomyosarcoma." Indian Journal of Obstetrics and Gynecology 10, no. 4 (2022): 199–202. http://dx.doi.org/10.21088/ijog.2321.1636.10422.3.

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Sarcomas are connective tissue cancers and Rhabdomyosarcomas are cancers originating from the skeletal muscle cells of the body. A 23 year old female unmarried, nulligravida presented in our emergency with the complaint of bleeding per vagina on and off since last 4 months. The lesion measured 9.2 (cc) x8.7 (cs)x7.8 (ap) cm. The lesion displaced the uterus superiorly distended the vaginal canal compressed the urinary bladder and urethra anteriorly but with no evidence of infiltration into the pelvic side wall and with maintained fat plane. Rest all pelvic organs as well as abdominal organs wer

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Varrior, Ajith Ramakumar, Hemangini Thakkar, and Sunita Kale. "Radiological features of multifocal embryonal rhabdomyosarcoma affecting the vagina and the urinary bladder in a pediatric patient." BMJ Case Reports 17, no. 6 (2024): e259549. http://dx.doi.org/10.1136/bcr-2023-259549.

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Rhabdomyosarcomas are the most common soft-tissue sarcomas, found usually in the younger age group. Histologically, they are subdivided into embryonal, alveolar, pleomorphic and not otherwise specified. They have a heterogenous appearance on imaging with few additional characteristic features based on the subtype. Botryoid variant of embryonal rhabdomyosarcoma commonly involves the genitourinary and the biliary system. They can be multifocal. Most of these lesions have a heterogenous appearance on imaging with areas of necrosis and haemorrhage. On ultrasound, they are polypoidal with cystic ar

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Petrilli, Lucia Lisa, Federica Riccio, Giulio Giuliani, et al. "Skeletal Muscle Subpopulation Rearrangements upon Rhabdomyosarcoma Development through Single-Cell Mass Cytometry." Journal of Clinical Medicine 10, no. 4 (2021): 823. http://dx.doi.org/10.3390/jcm10040823.

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The embryonal rhabdomyosarcoma (eRMS) is a soft tissue sarcoma commonly affecting the head and neck, the extremities and the genitourinary tract. To contribute to revealing the cell types that may originate this tumor, we exploited mass cytometry, a single-cell technique that, by using heavy-metal-tagged antibodies, allows the accurate monitoring of the changes occurring in the mononuclear cell composition of skeletal muscle tissue during tumor development. To this end, we compared cell populations of healthy muscles with those from spatiotemporal-induced eRMS tumors in a mouse model (LSL-Kras

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Kendall, Genevieve. "Abstract IA015: Comprehensive in vivo phenotyping of fusion-driven pediatric sarcomas." Cancer Research 85, no. 5_Supplement (2025): IA015. https://doi.org/10.1158/1538-7445.genfunc25-ia015.

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Abstract Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma that has molecular features of immature skeletal muscle. The most aggressive forms of rhabdomyosarcoma are driven by two genes that are inappropriately juxtaposed to form a fusion-oncogene. These fusion-oncogenes consists of transcription factors, various chromatin regulators, and kinases that obtain gain-of-function activities. Fusion-positive rhabdomyosarcomas have no targeted therapies. Patients are treated general chemotherapy, surgery, and radiation and survivors of childhood cancer have an increased risk of

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Mosoyan, M. S., I. M. Kagantsov, Yu V. Dinikina, et al. "Robotic cystprostatectomy in a 13-year-old child with prostate rhabdomyosarcoma." Urology Herald 12, no. 6 (2025): 67–75. https://doi.org/10.21886/2308-6424-2024-12-6-67-75.

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Introduction. R Rhabdomyosarcoma is the most common type of sarcoma in children, which can affect the genitourinary system. Treatment protocols for patients with rhabdomyosarcomas of the prostate and bladder differ, particularly regarding the need, extent, and timing of surgical treatment. Currently, there are two main treatment protocols for rhabdomyosarcomas of the bladder and prostate: the European (SIOP), approved by the International Society of Pediatric Urology, and the North American one, supported by the Children's Oncology Group (COG). Both protocols share the use of neoadjuvant chemo

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ITO, Kotaro, Akira TAKAHASHI, Yumiko KUBOTA, Juichiro NAKAYAMA, and Fumio YANAI. "Rhabdomyosarcoma." Nishi Nihon Hifuka 71, no. 3 (2009): 253–54. http://dx.doi.org/10.2336/nishinihonhifu.71.253.

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Okçu, Mehmet Fatih. "RHABDOMYOSARCOMA." Hematology, Transfusion and Cell Therapy 43 (November 2021): S8. http://dx.doi.org/10.1016/j.htct.2021.10.958.

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46

Heffner, Dennis K. "Rhabdomyosarcoma." Oncology Times 24, no. 12 (2002): 2. http://dx.doi.org/10.1097/01.cot.0000289327.14554.d0.

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Rajagopalan, Anuradha, Sarah C. Christenberry, and Venkataraman Ramachandran. "Rhabdomyosarcoma." Pediatrics In Review 43, no. 10 (2022): 599–600. http://dx.doi.org/10.1542/pir.2021-004977.

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Dasgupta, Roshni, Jörg Fuchs, and David Rodeberg. "Rhabdomyosarcoma." Seminars in Pediatric Surgery 25, no. 5 (2016): 276–83. http://dx.doi.org/10.1053/j.sempedsurg.2016.09.011.

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Seidal, T. "Rhabdomyosarcoma." Histopathology 17, no. 5 (1990): 482a—483. http://dx.doi.org/10.1111/j.1365-2559.1990.tb00780.x.

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Carter, R. L., L. G. Machin, and K. P. McCarthy. "Rhabdomyosarcoma." Histopathology 17, no. 5 (1990): 483–84. http://dx.doi.org/10.1111/j.1365-2559.1990.tb00781.x.

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