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Journal articles on the topic 'Rhbmp2'

Author: Grafiati

Published: 8 July 2023

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1

Colange, Ana Lucia, Carlos Sabino de Oliveira, Benedito Domingos Neto, Heloisa Sobreiro Selistre de Araújo, Eliane Trovatti, and Monica Rosas da Costa Iemma. "Effect on viability and cellular proliferation of rhBMP-2 immobilized on TEMPO modified cellulose hydrogel." Research, Society and Development 11, no. 11 (2022): e471111133260. http://dx.doi.org/10.33448/rsd-v11i11.33260.

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BMP´s are signaling proteins that belong to the Transforming Growth Factor-β (TGF-β) superfamily. These proteins promote the recruitment and differentiation of mesenchymal progenitor cells into bone forming cells, the osteoblasts and increase the rate of bone formation. The carrier systems to release rhBMP-2 to the action site are based on the use of free and soluble BMP incorporated into biopolymers such as collagen, gelatin, chitosan, hyaluronic acid and silk. The fused rhBMP-2-thioredoxin could be an interesting approach for new advances in the field of carrying systems of these growth fact

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Jeong, Byung-Chul, Hyuck Choi, Sung-Woong Hur, et al. "Repair of Cranial Bone Defects Using rhBMP2 and Submicron Particle of Biphasic Calcium Phosphate Ceramics with Through-Hole." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/926291.

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Recently a submicron particle of biphasic calcium phosphate ceramic (BCP) with through-hole (donut-shaped BCP (d-BCP)) was developed for improving the osteoconductivity. This study was performed to examine the usefulness of d-BCP for the delivery of osteoinductive rhBMP2 and the effectiveness on cranial bone regeneration. The d-BCP was soaked in rhBMP2 solution and then freeze-dried. Scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), and Raman spectroscopy analyses confirmed that rhBMP2 was well delivered onto the d-BCP surface and the through-hole. The bioactivity of th

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3

Alobaidaan, Raed, Jeremiah R. Cohen, Elizabeth L. Lord, et al. "Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population." Global Spine Journal 7, no. 8 (2017): 770–73. http://dx.doi.org/10.1177/2192568217696695.

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Study Design: Retrospective cohort study among Medicare beneficiaries who underwent posterior lumbar interbody fusion (PLIF) surgery. Objective: To identify the complication rates associated with the use of bone morphogenetic protein 2 (BMP2) in PLIF. Human BMP2 is commonly used in the “off-label” manner for various types of spine fusion procedures, including PLIF. However, recent studies have reported potential complications associated with the recombinant human BMP2 (rhBMP2) use in the posterior approach. Methods: Medicare records within the PearlDiver database were queried for patients unde

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Por, Yong-Chen, Carlos Raul Barceló, Kenneth E. Salyer, et al. "Bone Generation in the Reconstruction of a Critical Size Calvarial Defect in an Experimental Model†." Annals of the Academy of Medicine, Singapore 36, no. 11 (2007): 911–19. http://dx.doi.org/10.47102/annals-acadmedsg.v36n11p911.

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Objective: This study was designed to investigate the optimal combination of known osteogenic biomaterials with shape conforming struts to achieve calvarial vault reconstruction, using a canine model. Methods: Eighteen adolescent beagles were divided equally into 6 groups. A critical size defect of 6 x 2 cm traversed the sagittal suture. The biomaterials used for calvarial reconstruction were demineralised perforated bone matrix (DBM), recombinant human bone morphogenetic protein-2 (rhBMP2) and autogenous platelet-rich plasma (PRP). The struts used were cobalt chrome (metal) or resorbable plat

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Patel, Harshadkumar A., Ian J. Wellington, Klair Lubonja, et al. "Current Trends in Recombinant Human Bone Morphogenetic Protein 2 (rhBMP2) Usage for Spinal Fusion Surgery." Medicina 59, no. 5 (2023): 878. http://dx.doi.org/10.3390/medicina59050878.

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(1) Background: Since first approved by the FDA, on-label and off-label usage of recombinant human bone morphogenetic protein 2 (rhBMP2) for spinal fusion surgeries has become widespread. While many studies have investigated the safety and efficacy of its use, as well as its economic impact, few have looked at the current trends in its on- and off-label use. The goal of this study is to evaluate the current trends of on- and off-label rhBMP2 use for spinal fusion surgery. (2) Methods: A deidentified survey was created and electronically distributed to members of two international spine societi

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Fujioka-Kobayashi, Masako, Mustafa Abd El Raouf, Nikola Saulacic, et al. "Superior bone-inducing potential of rhBMP9 compared to rhBMP2." Journal of Biomedical Materials Research Part A 106, no. 6 (2018): 1561–74. http://dx.doi.org/10.1002/jbm.a.36359.

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Fujioka‐Kobayashi, Masako, Mustafa Abd El Raouf, Nikola Saulacic, et al. "Superior bone‐inducing potential of rhBMP9 compared to rhBMP2." Journal of Biomedical Materials Research Part A 107, no. 6 (2019): 1351. http://dx.doi.org/10.1002/jbm.a.36591.

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8

Zhao, He, Yali Ma, Dahui Sun, Wendi Ma, Jihang Yao, and Mei Zhang. "Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes." Journal of Nanomaterials 2019 (August 29, 2019): 1–13. http://dx.doi.org/10.1155/2019/8106985.

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DEX and rhBMP2-loaded core-shell nanofiber membranes were synthesized by electrospinning method in one step. Zein/PLLA, Zein-DEX/PLLA, Zein/PLLA-rhBMP2, and Zein-DEX/PLLA-rhBMP2 were fabricated; and morphology, hydrophilicity, mechanics properties, in vitro drug release behavior, cell proliferation, and osteogenic differentiation were investigated. The results showed that the dual-release system containing rhBMP2 and DEX prepared by electrospinning had rough surface, constant drug release behavior, and could also significantly promote cell proliferation and osteogenic differentiation of RMSCs,

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9

Lao, Lifeng, Jeremiah R. Cohen, Zorica Buser, et al. "Trends Analysis of rhBMP2 Utilization in Single-Level Anterior Lumbar Interbody Fusion in the United States." Global Spine Journal 8, no. 2 (2017): 137–41. http://dx.doi.org/10.1177/2192568217701119.

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Study Design: Retrospective case study. Objective: To evaluate the trends and demographics of recombinant human bone morphogenetic protein 2 (rhBMP2) utilization in single-level anterior lumbar interbody fusion (ALIF) in the United States. Methods: Patients who underwent single-level ALIF from 2005 to 2011 were identified by searching ICD-9 diagnosis and procedure codes in the PearlDiver Patient Records Database (PearlDiver Technologies, Fort Wayne, IN), a national database of orthopedic insurance records. The year of procedure, age, gender, and region of the United States were analyzed for ea

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Esmail, Nabil, Zorica Buser, Jeremiah R. Cohen, et al. "Postoperative Complications Associated With rhBMP2 Use in Posterior/Posterolateral Lumbar Fusion." Global Spine Journal 8, no. 2 (2017): 142–48. http://dx.doi.org/10.1177/2192568217698141.

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Study Design: Retrospective database review. Objective: Posterior/posterolateral lumbar fusion (PLF) is an effective treatment for a variety of spinal disorders; however, variations in surgical technique have different complication profiles. The aim of our study was to quantify the frequency of various complications in patients undergoing PLF with and without human recombinant bone morphogenetic protein 2 (rhBMP2). Methods: We queried the orthopedic subset of the Medicare database (PearlDiver) between 2005 and 2011 for patients undergoing PLF procedures with and without rhBMP2. Complication an

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Yao, Jihang, Yilong Wang, Wendi Ma, Wenying Dong, Mei Zhang, and Dahui Sun. "Dual-Drug-Loaded Silk Fibroin/PLGA Scaffolds for Potential Bone Regeneration Applications." Journal of Nanomaterials 2019 (July 16, 2019): 1–16. http://dx.doi.org/10.1155/2019/8050413.

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Developing scaffold materials with excellent biocompatibility, mechanical properties, and controlled drug release properties is vital to tissue engineering. In this study, we fabricated silk fibroin (SF)/poly(lactide-co-glycolide) (PLGA) nanofiber scaffolds containing recombinant human bone morphogenetic protein 2 (rhBMP2) and dexamethasone (DXM) via coaxial electrospinning, which were used in in vitro bone formation with rat bone marrow mesenchymal stem cells (rBMSCs). An in vitro drug release study was adopted to evaluate the sustained release potential of the core-shell structured nanofiber

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Hanif, Muhammad Umair, Roquyya Gul, Muhammad Imran Hanif, and Abid Ali Hashmi. "Heterologous Secretory Expression and Characterization of Dimerized Bone Morphogenetic Protein 2 inBacillus subtilis." BioMed Research International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/9350537.

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Recombinant human Bone Morphogenetic Protein 2 (rhBMP2) has important applications in the spine fusion and ortho/maxillofacial surgeries. Here we first report the secretory expression of biological active dimerized rhBMP2 fromBacillus subtilissystem. The mature domain of BMP2 gene was amplified from pTz57R/BMP2 plasmid. By using pHT43 expression vector two constructs, pHT43-BMP2-M (single BMP2 gene) and pHT43-BMP2-D (two BMP2 genes coupled with a linker to produce a dimer), were designed. After primary cloning (DH5αstrain) and sequence analysis, constructs were transformed intoBacillus subtili

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13

Zheng, Yuanna, Gang Wu, Juan Zhao, Linhong Wang, Ping Sun, and Zhiyuan Gu. "rhBMP2/7 Heterodimer: An Osteoblastogenesis Inducer of Not Higher Potency but Lower Effective Concentration Compared with rhBMP2 and rhBMP7 Homodimers." Tissue Engineering Part A 16, no. 3 (2010): 879–87. http://dx.doi.org/10.1089/ten.tea.2009.0312.

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Behrens, Christina, Philipp Kauffmann, Nikolaus von Hahn, Uwe Schirmer, Klaus Liefeith, and Henning Schliephake. "Collagen-Based Osteogenic Nanocoating of Microrough Titanium Surfaces." International Journal of Molecular Sciences 23, no. 14 (2022): 7803. http://dx.doi.org/10.3390/ijms23147803.

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The aim of the present study was to develop a collagen/heparin-based multilayer coating on titanium surfaces for retarded release of recombinant human bone morphogenic protein 2 (rhBMP2) to enhance the osteogenic activity of implant surfaces. Polyelectrolyte multilayer (PEM) coatings were constructed on sandblasted/acid-etched surfaces of titanium discs using heparin and collagen. PEM films of ten double layers were produced and overlayed with 200 µL of a rhBMP2 solution containing 15 µg rhBMP2. Subsequently, cross-linking of heparin molecules was performed using EDC/NHS chemistry to immobiliz

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Jiang, Ying, Weihao Li, and Congyun Bao. "A Novel Glucose-Sensitive Scaffold Accelerates Osteogenesis in Diabetic Conditions." BioMed Research International 2022 (March 18, 2022): 1–10. http://dx.doi.org/10.1155/2022/4133562.

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Mandibular bone regeneration is still a big challenge in those diabetic patients with poorly controlled blood glucose. In this study, we prepared a novel glucose-sensitive controlled-release fiber scaffold (PVA-HTCC/PEO-rhBMP2-glucose oxidase (PHPB-G)), which contained the recombinant human bone morphogenetic protein 2 (rhBMP2) by coaxial cospinning and grafted with glucose oxidase (GOD). We presented evidence that PHPB-G could undergo a series of structural changes with the blood glucose and promoted bone regeneration in diabetic rat. PHPB-G expanded the voids in nanofibers when blood glucose

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Maia-Pinto, Marianna O. C., Ana Carolina B. Brochado, Bruna Nunes Teixeira, et al. "Biomimetic Mineralization on 3D Printed PLA Scaffolds: On the Response of Human Primary Osteoblasts Spheroids and In Vivo Implantation." Polymers 13, no. 1 (2020): 74. http://dx.doi.org/10.3390/polym13010074.

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This study aimed to assess the response of 3D printed polylactic acid (PLA) scaffolds biomimetically coated with apatite on human primary osteoblast (HOb) spheroids and evaluate the biological response to its association with Bone Morphogenetic Protein 2 (rhBMP-2) in rat calvaria. PLA scaffolds were produced via 3D printing, soaked in simulated body fluid (SBF) solution to promote apatite deposition, and characterized by physical-chemical, morphological, and mechanical properties. PLA-CaP scaffolds with interconnected porous and mechanical properties suitable for bone repairing were produced w

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17

Lian, Huan, Han Wang, Qianqian Han, and Chunren Wang. "Quantification of rhBMP2 in bioactive bone materials." Regenerative Biomaterials 7, no. 1 (2019): 71–75. http://dx.doi.org/10.1093/rb/rbz038.

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Abstract Bone morphogenetic protein (BMP), belongs to transforming growth factor-β (TGF-β) superfamily except BMP-1. Implanting BMP into muscular tissues induces ectopic bone formation at the site of implantation, which provides opportunity for the treatment of bone defects. Recombinant human BMP-2 (rhBMP-2) has been used clinically, but the lack of standard methods for quantifying rhBMP-2 biological activity greatly hindered the progress of commercialization. In this article, we describe an in vitro rhBMP-2 quantification method, as well as the data analyzation pipeline through logistic regre

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Baskin, Jonathan Zvi, Alvin Ko, and Steven Eppell. "rhBMP2 Release Profiles in Collagen-Apatite Composites." Otolaryngology–Head and Neck Surgery 141, no. 2_suppl (2009): P40. http://dx.doi.org/10.1016/j.otohns.2009.06.115.

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Fujioka-Kobayashi, Masako, Kosaku Sawada, Eizaburo Kobayashi, Benoit Schaller, Yufeng Zhang, and Richard J. Miron. "Osteogenic potential of rhBMP9 combined with a bovine-derived natural bone mineral scaffold compared to rhBMP2." Clinical Oral Implants Research 28, no. 4 (2016): 381–87. http://dx.doi.org/10.1111/clr.12804.

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20

Cicciù, M., A. S. Herford, E. Stoffella, G. Cervino, and D. Cicciù. "Protein-Signaled Guided Bone Regeneration Using Titanium Mesh and Rh-BMP2 in Oral Surgery: A Case Report Involving Left Mandibular Reconstruction after Tumor Resection." Open Dentistry Journal 6, no. 1 (2012): 51–55. http://dx.doi.org/10.2174/1874210601206010051.

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Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive protein approved for use in oral and maxillofacial defect reconstruction. Growth factors act as mediators of cellular growth on morphogenesis and mythogenesis phases. Utilized as recombinant proteins, these growth factors need the presence of local target cells capable of obtaining the required results. This cell population may be present at the wound site or added to scaffolding material before implantation at the surgical site. The aim of this study is to evaluate the clinical and radiographic results of a reported

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Fujioka-Kobayashi, Masako, Kosaku Sawada, Eizaburo Kobayashi, Benoit Schaller, Yufeng Zhang, and Richard J. Miron. "Recombinant Human Bone Morphogenetic Protein 9 (rhBMP9) Induced Osteoblastic Behavior on a Collagen Membrane Compared With rhBMP2." Journal of Periodontology 87, no. 6 (2016): e101-e107. http://dx.doi.org/10.1902/jop.2016.150561.

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22

Saulacic, Nikola, Benoit Schaller, Fernando Muñoz, et al. "RhBMP9 in comparison to rhBMP2 for ridge augmentation following tooth extraction - an experimental study in the Beagle dog." Clinical Oral Implants Research 29 (October 2018): 43. http://dx.doi.org/10.1111/clr.13356.

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23

Chang, Po-Chun, Bu-Yuan Liu, Cheng-Meei Liu, et al. "Bone tissue engineering with novel rhBMP2-PLLA composite scaffolds." Journal of Biomedical Materials Research Part A 81A, no. 4 (2007): 771–80. http://dx.doi.org/10.1002/jbm.a.31031.

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24

Ivanjko, Natalia, Nikola Stokovic, Marina Milesevic, and Slobodan Vukicevic. "Comparison of efficacy of rhBMP2 and rhBMP6 delivered within autologous blood coagulum with synthetic ceramics in rat subcutaneous assay." Bone Reports 16 (May 2022): 101325. http://dx.doi.org/10.1016/j.bonr.2022.101325.

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Buser, Zorica, Darrel Brodke, Nabil Esmail, et al. "Postoperative Complications Associated with rhBMP2 use in Posterior Lumbar Fusion." Global Spine Journal 6, no. 1_suppl (2016): s—0036–1582611—s—0036–1582611. http://dx.doi.org/10.1055/s-0036-1582611.

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Hou, Xiao-Fei, Dong-Wei Fan, Chui-Guo Sun, and Zhong-Qiang Chen. "Recombinant human bone morphogenetic protein-2–induced ossification of the ligamentum flavum in rats and the associated global modification of histone H3." Journal of Neurosurgery: Spine 21, no. 3 (2014): 334–41. http://dx.doi.org/10.3171/2014.4.spine13319.

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Object The primary object of this investigation was to study recombinant human bone morphogenetic protein–2 (rhBMP-2)–induced ossification of the ligamentum flavum and associated histone H3 modification in a rat model. In an additional set of studies the authors investigated spinal cord and behavioral changes in the same model. Methods The authors report on 2 separate sets of studies. A total of 90 rats were used for the 2 sets of studies (45 each); in each study, a lyophilized rhBMP-2 and collagen mixture (20 μg rhBMP-2 and 200 μl collagen) was implanted in the lumbar extradural space in 18 r

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El-Ghannam, Ahmed. "Bioceramic Drug Delivery System for Cancer Treatment and Regenerative Medicine." Key Engineering Materials 696 (May 2016): 245–49. http://dx.doi.org/10.4028/www.scientific.net/kem.696.245.

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Silica-calcium-phosphate composite (SCPC) is a drug delivery platform that has successfully demonstrated the ability to bind and release several therapeutics including antibiotics, peptides, anticancer drugs, and growth factors. It has successfully demonstrated a unique capacity for bone regeneration. The present studies address the effect of the phosphate and silicate functional groups on drug binding and controlled release kinetics of Cisplatin (Cis). Moreover, the roles of ceramic composition and resorbability on rhBMP2 release kinetics and bone regeneration in a critical size calvarial def

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Saulacic, Nikola, Benoit Schaller, Fernando Muñoz, et al. "Recombinant human BMP9 (RhBMP9) in comparison with rhBMP2 for ridge augmentation following tooth extraction: An experimental study in the Beagle dog." Clinical Oral Implants Research 29, no. 10 (2018): 1050–59. http://dx.doi.org/10.1111/clr.13371.

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Abarrategi, Ander, Ana Civantos, Viviana Ramos, José Vicente Sanz Casado, and José Luís López-Lacomba. "Chitosan Film as rhBMP2 Carrier: Delivery Properties for Bone Tissue Application." Biomacromolecules 9, no. 2 (2008): 711–18. http://dx.doi.org/10.1021/bm701049g.

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30

Tian, Zhichao, Yuanli Zhu, Jinjun Qiu, et al. "Synthesis and characterization of UPPE-PLGA-rhBMP2 scaffolds for bone regeneration." Journal of Huazhong University of Science and Technology [Medical Sciences] 32, no. 4 (2012): 563–70. http://dx.doi.org/10.1007/s11596-012-0097-4.

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31

Balaji, S. M. "Use of rhBMP2 with bone grafts in pediatric jaw resection cases." International Journal of Oral and Maxillofacial Surgery 40, no. 10 (2011): 1096. http://dx.doi.org/10.1016/j.ijom.2011.07.236.

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32

Lohse, N., N. Moser, S. Backhaus, T. Annen, M. Epple, and H. Schliephake. "Continuous delivery of rhBMP2 and rhVEGF165 at a certain ratio enhances bone formation in mandibular defects over the delivery of rhBMP2 alone — An experimental study in rats." Journal of Controlled Release 220 (December 2015): 201–9. http://dx.doi.org/10.1016/j.jconrel.2015.10.032.

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Lu, Daniel C., Luis M. Tumialán, and Dean Chou. "Multilevel anterior cervical discectomy and fusion with and without rhBMP-2: a comparison of dysphagia rates and outcomes in 150 patients." Journal of Neurosurgery: Spine 18, no. 1 (2013): 43–49. http://dx.doi.org/10.3171/2012.10.spine10231.

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Object Reported complications of recombinant human bone morphogenetic protein–2 (rhBMP-2) use in anterior cervical discectomy and fusion (ACDF) cases include dysphagia and cervical swelling. However, dysphagia often occurs after multilevel ACDF procedures performed with allograft (without BMP) as well. To date, there has been no large study comparing the dysphagia rates of patients who have undergone multilevel ACDF using allograft spacers with those who underwent ACDF using polyetheretherketone (PEEK) cages filled with rhBMP2. The authors report one of the first such comparisons between these

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Durham, Emily L., Rajiv Kishinchand, Zachary J. Grey, and James J. Cray. "rhBMP2 alone does not induce macrophage polarization towards an increased inflammatory response." Molecular Immunology 117 (January 2020): 94–100. http://dx.doi.org/10.1016/j.molimm.2019.10.021.

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35

Lindley, Emily, Susan Estes, Evalina Burger, and Vikas Patel. "P82. Evaluation of rhBMP2 Fibrin Glue-associated Edema in Rabbit Muscle Tissue." Spine Journal 8, no. 5 (2008): 140S—141S. http://dx.doi.org/10.1016/j.spinee.2008.06.724.

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Preativatanyou, Kanok, and Sittisak Honsawek. "RhBMP-2 and -7 combined with absorbable collagen sponge carrier enhance ectopic bone formation: An in vivo bioassay." Asian Biomedicine 5, no. 1 (2011): 85–92. http://dx.doi.org/10.5372/1905-7415.0501.010.

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Abstract Background: Recombinant human bone morphogenetic proteins (rhBMPs) have been characterized especially chondrogenic and osteogenic activity both in vitro and in vivo studies. However, delivery of more than one growth factor by sustained release carrier to orthopedic site has yet been questionable in terms of efficacy and synergism. Objective: Evaluate osteoinductivity and synergistic effect of rhBMP-2 and -7 using absorbable collagen sponge (ACS) carrier system in vivo. Methods: cDNA of BMP-2 and -7 active domains were cloned and expressed in Escherichia coli BL21 StarTM (DE3) using pR

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Ryu, Dalsung, Byung-Hak Yoon, Chang-Hyun Oh, et al. "Activin A/BMP2 Chimera (AB204) Exhibits Better Spinal Bone Fusion Properties than rhBMP2." Journal of Korean Neurosurgical Society 61, no. 6 (2018): 669–79. http://dx.doi.org/10.3340/jkns.2017.0295.

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Schliephake, H., H. A. Weich, J. Schulz, and R. Gruber. "In vitro characterization of a slow release system of polylactic acid and rhBMP2." Journal of Biomedical Materials Research Part A 83A, no. 2 (2007): 455–62. http://dx.doi.org/10.1002/jbm.a.31227.

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Nguyen, Thi-Hiep, and Byong-Taek Lee. "In vitroandin vivostudies of rhBMP2-coated PS/PCL fibrous scaffolds for bone regeneration." Journal of Biomedical Materials Research Part A 101A, no. 3 (2012): 797–808. http://dx.doi.org/10.1002/jbm.a.34382.

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Mukhametov, U. F., S. V. Lyulin, D. Yu Borzunov, and I. F. Gareev. "Evaluation of the potential immunogenicity of recombinant human bone morphogenetic proteins." Ural Medical Journal 21, no. 5 (2022): 116–27. http://dx.doi.org/10.52420/2071-5943-2022-21-5-116-127.

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Introduction. Bone morphogenetic proteins (BMPs) are a subgroup of the transforming growth factor-β (TGF-β) superfamily where they play an important role in bone formation and repair. Recombinant human bone morphogenetic proteins (rhBMPs) are currently being clinically evaluated for their effectiveness in enhancing bone tissue regeneration processes after injuries and diseases of the musculoskeletal system. Clinical trials were accompanied by detailed safety assessments using both in vitro and in vivo assays. Concerns were initially raised about the immunogenicity of some therapeutic proteins

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Joseph, Vivek, and Yoga Raja Rampersaud. "Heterotopic Bone Formation With the Use of rhBMP2 in Posterior Minimal Access Interbody Fusion." Spine 32, no. 25 (2007): 2885–90. http://dx.doi.org/10.1097/brs.0b013e31815b7596.

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Berven, Sigurd, Stephen Ondra, Youjeong Kim, Jeffrey Toth, John Louis-Ugbo, and Maneesh Bawa. "43. A Direct Comparison of rhOP1 and rhBMP2 in a Rhesus Monkey Posterolateral Environment." Spine Journal 8, no. 5 (2008): 21S—22S. http://dx.doi.org/10.1016/j.spinee.2008.06.050.

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Herford, A. S., E. Stoffella, and M. Cicciù. "5 Years follow up of patient treated with rhBMP2 for large mandibulary bone defects." International Journal of Oral and Maxillofacial Surgery 40, no. 10 (2011): 1126. http://dx.doi.org/10.1016/j.ijom.2011.07.338.

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Mukhametov, U. F., S. V. Lyulin, D. Yu Borzunov, I. F. Gareev, O. A. Beylerli, and A. A. Sufianov. "Heterotopic ossification as a side effect of the use of recombinant human bone morphogenetic proteins." Genij Ortopedii 28, no. 1 (2022): 123–32. http://dx.doi.org/10.18019/1028-4427-2022-28-1-123-132.

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Introduction Heterotopic ossification (HO), also known as myositis ossification, paraosteoarthropathy, or heterotopic calcification, among others, is a common pathological condition that refers to ectopic bone formation in soft tissues. Although the molecular mechanism of HO is not fully understood, it is believed that signaling of bone morphogenetic proteins (BMPs) plays a key role in the overall process of HO. Today, recombinant human BMP-2 (rhBMP-2) and recombinant human BMP-7 (rhBMP-7) have been already actively used in clinical practice in the treatment of bone defects. However, despite t

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Wang, Jingxiao, Yuanna Zheng, Juan Zhao, et al. "Low-dose rhBMP2/7 heterodimer to reconstruct peri-implant bone defects: a micro-CT evaluation." Journal of Clinical Periodontology 39, no. 1 (2011): 98–105. http://dx.doi.org/10.1111/j.1600-051x.2011.01807.x.

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Hye Kim, Ji, Sa Ya Lee, Mi Seon Goh, et al. "The use of rhBMP2 loaded implant fixture and 3D-printed scaffold for vertical bone augmentation." Clinical Oral Implants Research 29 (October 2018): 107. http://dx.doi.org/10.1111/clr.2_13357.

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Yoon, Seung Hwan, JiYong Kim, and Chang Hyun Oh. "The Activin A/BMP 2 Chimera AB204 Exhibits Superior Spinal Bone Fusion Properties over rhBMP2." Spine Journal 15, no. 10 (2015): S88. http://dx.doi.org/10.1016/j.spinee.2015.07.016.

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Anand, Neel, John F. Hamilton, Brian Perri, Hamid Miraliakbar, and Theodore Goldstein. "Cantilever TLIF With Structural Allograft and RhBMP2 for Correction and Maintenance of Segmental Sagittal Lordosis." Spine 31, no. 20 (2006): E748—E753. http://dx.doi.org/10.1097/01.brs.0000240211.23617.ae.

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Hwang, Chang Ju, Alexander R. Vaccaro, James P. Lawrence, et al. "Immunogenicity of bone morphogenetic proteins." Journal of Neurosurgery: Spine 10, no. 5 (2009): 443–51. http://dx.doi.org/10.3171/2009.1.spine08473.

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Abstract:

Object The object of this paper is to review the immunogenicity of bone morphogenetic proteins (BMPs) and to compare the results of the immunogenicity characterization and clinical consequences between recombinant human (rh)BMP-2 and recombinant human osteogenic protein-1 (rhOP-1/BMP-7). Methods The immunogenicity of therapeutic proteins and its clinical effects were reviewed. The characteristics of BMPs were also described in terms of immunogenicity. The methods and results of antibody detection in various clinical trials of rhBMP-2 and rhOP-1 were compared, including the most recent studies

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Kim, Sungwon, Cheonil Park, Byeong-Seok Moon, Hyoun-Ee Kim, and Tae-Sik Jang. "Enhancement of osseointegration by direct coating of rhBMP-2 on target-ion induced plasma sputtering treated SLA surface for dental application." Journal of Biomaterials Applications 31, no. 6 (2016): 807–18. http://dx.doi.org/10.1177/0885328216679761.

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Owing to the excellent bioactive properties of recombinant human bone morphogenetic proteins (rhBMPs), dentistry considers them as a fascinating adjuvant alternative for enhancing bone regeneration and bone-to-implant junction in the early implantation stages. However, stable loading and delivery efficiency of rhBMPs on the implant surfaces involve major concerns because of the harsh wearing condition under load during implantation. In this study, to achieve successful rhBMP-2 delivery, a nanoporous surface structure is introduced on the sandblasting with large grit and acid-etching (SLA)-trea

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