Relevant bibliographies by topics / Rhesus macaque

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Academic literature on the topic 'Rhesus macaque'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 June 2025

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Journal articles on the topic "Rhesus macaque"

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MALAIVIJITNOND, SUCHINDA, OSAMU TAKENAKA, YOSHI KAWAMOTO, NONTAKORN URASOPON, ISLAMUL HADI, and YUZURU HAMADA. "Anthropogenic Macaque Hybridization and Genetic Pollution of a Threatened Population." Tropical Natural History 7, no. 1 (2007): 11–23. https://doi.org/10.58837/tnh.7.1.102915.

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Interspecific matings between one released male pig-tailed macaque and female rhesus macaques were observed in a small isolated semi-wild troop of rhesus macaques in northeastern Thailand. Two of three juvenile males suspected to be hybrids based on their appearance, were caught and examined morphologically and genetically. Both suspected hybrids had a dark brown and anteriorly narrow crown patch and thinly haired tails as are common in pig-tailed macaques, and tail-lengths in the range of rhesus macaque. Male no. 19 showed neither cheek hair whorl nor the bipartite pattern of pelage color characteristics of rhesus macaque, whereas male no. 14 displayed both of these characters. We could not determine whether they were truly hybrids based on our morphological assessments and so both animals were also examined genetically. Study of variation at the Y-chromosome linked TSPY locus showed that although monkey no. 19 was sired by the pig-tailed macaque, monkey no. 14 was sired by a rhesus macaque. A mtDNA analysis indicated that both suspected hybrids were sons of rhesus mothers. Electrophoretic examination of blood hemoglobin-α protein confirmed that only monkey no. 19 was truly a hybrid. Although only one individual was confirmed to be hybrid in this troop, the hybridization could become a severe threat to the genetic integrity of the native troop and may hinder the tracing of the evolutionary history of the population. It is especially true in the rhesus populations which are now very rare in Thailand.
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Hasan, Md Mahedi, and Md Azizul Hakim. "Diet, Feeding Habit and Behavioral Activity of Rhesus Macaque (Macaca mulatta) at Charmuguria of Madaripur, Bangladesh." Jagannath University Journal of Life and Earth Sciences 9, no. 2 (2024): 147–62. http://dx.doi.org/10.3329/jnujles.v9i2.72921.

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Diet, feeding habits, and behavioral activities of Rhesus macaque (Macaca Mulatta) were studied at Charmuguria of Madaripur district from March 2021 to December 2021. Among the five troops, one troop with four age-sex individuals was selected for data collection. Scan sampling methods at 10-minute intervals were used for data collection. Rhesus macaque spent 72% of feeding time on natural foods and 28% on provisioned foods. During the study period, 11 types of provisioned foods were recorded as a diet of Rhesus macaque, of which 73% were unprocessed food, and 27% were processed food. Rhesus macaque depended on various types of provisioned foods like bananas, peanuts, bread, vegetables, guava, chips, and pet foods. A total of 24 plant species belonging to 20 families were identified, which provided food for the studied group. Among the recorded plant families, the Fabaceae family provided the highest portion of the macaque's diet during the study period. Among the natural food items, 34% were fruits, followed by 27% of leaves, 12% animal matter, grasses (7%), flowers (6%), seeds (4.5%), grains (3%), buds & shoot (2.5%), drinking water (2%), plant roots (1.5%) and soil (0.5%). The Rhesus macaques spent the highest time in resting (37.5%), followed by feeding (25.5%), moving (20.4%), grooming (8.5%), then playing (3.6%), while submission and aggression had 3% and 1.5 % respectively. These days, people are destroying macaque habitats and their feeding plants, so they can't move freely and don't get sufficient food. Therefore, the government should take practical steps to conserve Rhesus macaque. Jagannath University Journal of Life and Earth Sciences, 9(2): 147-162, 2023 (December)
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Smith, Autumn L., Darla H. Black, and R. Eberle. "Molecular Evidence for Distinct Genotypes of Monkey B Virus (Herpesvirus Simiae) Which Are Related to the Macaque Host Species." Journal of Virology 72, no. 11 (1998): 9224–32. http://dx.doi.org/10.1128/jvi.72.11.9224-9232.1998.

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ABSTRACT Although monkey B virus (herpesvirus simiae; BV) is common in all macaque species, fatal human infections appear to be associated with exposure to rhesus macaques (Macaca mulatta), suggesting that BV isolates from rhesus monkeys may be more lethal to nonmacaques than are BV strains indigenous to other macaque species. To determine if significant differences that would support this supposition exist among BV isolates, we compared multiple BV strains isolated from rhesus, cynomolgus, pigtail, and Japanese macaques. Antigenic analyses indicated that while the isolates were very closely related to one another, there are some antigenic determinants that are specific to BV isolates from different macaque species. Restriction enzyme digest patterns of viral DNA revealed marked similarities between rhesus and Japanese macaque isolates, while pigtail and cynomolgus macaque isolates had distinctive cleavage patterns. To further compare genetic diversity among BV isolates, DNA sequences from two regions of the viral genome containing genes that are conserved (UL27 and US6) and variable (US4 and US5) among primate alphaherpesviruses, as well as from two noncoding intergenic regions, were determined. From these sequence data and a phylogenetic analysis of them it was evident that while all isolates were closely related strains of BV, there were three distinct genotypes. The three BV genotypes were directly related to the macaque species of origin and were composed of (i) isolates from rhesus and Japanese macaques, (ii) cynomolgus monkey isolates, and (iii) isolates from pigtail macaques. This study demonstrates the existence of different BV genotypes which are related to the macaque host species and thus provides a molecular basis for the possible existence of BV isolates which vary in their levels of pathogenicity for nonmacaque species.
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Matson, Cayman, Nicholas Castle, and Chenkai Dai. "Developing a Virtual Model of the Rhesus Macaque Inner Ear." Bioengineering 11, no. 11 (2024): 1158. http://dx.doi.org/10.3390/bioengineering11111158.

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A virtual model of the rhesus macaque inner ear was created in the present study. Rhesus macaques have been valuable in cochlear research; however, their high cost prompts a need for alternative methods. Finite Element (FE) analysis offers a promising solution by enabling detailed simulations of the inner ear. This study employs FE analysis to create a virtual model of the rhesus macaque’s inner ear, reconstructed from MRI scans, to explore how cochlear implants (CIs) impact residual hearing loss. Harmonic-acoustic simulations of sound wave transmission indicate that CIs have minor effects on the displacement of the basilar membrane and thus minimally impact residual hearing loss post-implantation, but stiffening of the round window membrane worsens this effect. While the rhesus macaque FE model presented in this study shows some promise, its potential applications will require further validation through additional simulations and experimental studies.
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DiVincenti, L., A. Rehrig, and J. Wyatt. "Interspecies pair housing of macaques in a research facility." Laboratory Animals 46, no. 2 (2012): 170–72. http://dx.doi.org/10.1258/la.2011.011134.

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The eighth edition of The Guide for the Care and Use of Laboratory Animals establishes social housing as the ‘default’ for social species including non-human primates. The advantages of social housing for primates have been well established, but small research facilities housing few primates in indoor cages have struggled with social housing as a result of limitations on appropriate housing and availability of compatible monkeys. Here, we report a novel approach to pair housing macaques – crossing species. We have successfully pair housed an intact male rhesus macaque with an intact male cynomolgus macaque, and an adult female rhesus macaque with numerous subadult female cynomolgus macaques. Monkeys in these pairs established dominant–subordinate relationships similar to same-species pairs. Rhesus and cynomolgus macaques can be successfully paired for the purpose of social housing in facilities with limited numbers of monkeys.
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Norris, Karen A., Hans Wildschutte, Jennifer Franko, and Kathryn F. Board. "Genetic Variation at the Mitochondrial Large-Subunit rRNA Locus of Pneumocystis Isolates from Simian Immunodeficiency Virus-Infected Rhesus Macaques." Clinical Diagnostic Laboratory Immunology 10, no. 6 (2003): 1037–42. http://dx.doi.org/10.1128/cdli.10.6.1037-1042.2003.

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ABSTRACT The nucleotide sequences of a segment of the Pneumocystis mitochondrial large-subunit (mt LSU) rRNA gene from rhesus macaques coinfected with simian immunodeficiency virus (SIV) and Pneumocystis carinii were examined. Of 12 isolates examined, 3 were found to be identical and the others showed substantial sequence variation, with up to 13% divergence among variants. We identified two general sequence types that differed at several sites, including a conserved 26-nucleotide insertion. Four monkeys had evidence of two Pneumocystis variants present simultaneously, indicative of a mixed infection. There was a high degree of variance between the rhesus macaque-derived Pneumocystis mt LSU rRNA gene sequence and the cognate sequences in Pneumocystis organisms derived from other hosts. Analysis of the mt LSU rRNA genes of Pneumocystis organisms derived from rhesus macaques and several other mammalian hosts supports the observation that rhesus macaque-derived Pneumocystis is most closely related to human-derived Pneumocystis. In addition, the data identify the mt LSU rRNA gene as an informative locus for transmission and epidemiological studies of the SIV-rhesus macaque model of Pneumocystis infection.
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Novembre, Francis J., Juliette De Rosayro, Shawn P. O’Neil, Daniel C. Anderson, Sherry A. Klumpp, and Harold M. McClure. "Isolation and Characterization of a Neuropathogenic Simian Immunodeficiency Virus Derived from a Sooty Mangabey." Journal of Virology 72, no. 11 (1998): 8841–51. http://dx.doi.org/10.1128/jvi.72.11.8841-8851.1998.

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ABSTRACT Transfusion of blood from a simian immunodeficiency virus (SIV)- and simian T-cell lymphotropic virus-infected sooty mangabey (designated FGb) to rhesus and pig-tailed macaques resulted in the development of neurologic disease in addition to AIDS. To investigate the role of SIV in neurologic disease, virus was isolated from a lymph node of a pig-tailed macaque (designated PGm) and the cerebrospinal fluid of a rhesus macaque (designated ROn2) and passaged to additional macaques. SIV-related neuropathogenic effects were observed in 100% of the pig-tailed macaques inoculated with either virus. Lesions in these animals included extensive formation of SIV RNA-positive giant cells in the brain parenchyma and meninges. Based upon morphology, the majority of infected cells in both lymphoid and brain tissue appeared to be of macrophage lineage. The virus isolates replicated very well in pig-tailed and rhesus macaque peripheral blood mononuclear cells (PBMC) with rapid kinetics. Differential replicative abilities were observed in both PBMC and macrophage populations, with viruses growing to higher titers in pig-tailed macaque cells than in rhesus macaque cells. An infectious molecular clone of virus derived from the isolate from macaque PGm (PGm5.3) was generated and was shown to have in vitro replication characteristics similar to those of the uncloned virus stock. While molecular analyses of this virus revealed its similarity to SIV isolates from sooty mangabeys, significant amino acid differences in Env and Nef were observed. This virus should provide an excellent system for investigating the mechanism of lentivirus-induced neurologic disease.
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COHEN, Ofer, Chanoch KRONMAN, Baruch VELAN, and Avigdor SHAFFERMAN. "Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta)." Biochemical Journal 378, no. 1 (2004): 117–28. http://dx.doi.org/10.1042/bj20031305.

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An array of 13 biochemically well defined molecular forms of bovine, human and newly cloned rhesus macaque (Macaca mulatta) AChEs (acetylcholinesterases) differing in glycosylation and subunit assembly status were subjected to comparative pharmacokinetic studies in mice and rhesus macaques. The circulatory lifetimes of recombinant bovine, macaque and human AChEs in mice were governed by previously determined hierarchical rules; the longest circulatory residence time was obtained when AChE was fully sialylated and tetramerized [Kronman, Chitlaru, Elhanany, Velan and Shafferman (2000) J. Biol. Chem. 275, 29488–29502; Chitlaru, Kronman, Velan and Shafferman (2001) Biochem. J. 354, 613–625]. In rhesus macaques, bovine molecular forms still obeyed the same hierarchical rules, whereas primate AChEs showed significant deviation from this behaviour. Residence times of human and rhesus AChEs were effectively extended by extensive sialylation, but subunit tetramerization and N-glycan addition had a marginal effect on their circulatory longevity in macaques. It appears that the major factor responsible for the differential pharmacokinetics of bovine and primate AChEs in macaques is related to differences in primary structure, suggesting the existence of a specific mechanism for the circulatory clearance of primate AChEs in rhesus macaques. The 35 amino acids that differ between bovine and primate AChEs are clustered within three defined domains, all located at the enzyme surface, and may therefore mediate the facilitated removal of primate cholinesterases specifically from the circulation of monkeys. These surface domains can be effectively masked by poly(ethylene glycol) appendage, resulting in the generation of chemically modified human and macaque AChEs that reside in the circulation for extraordinarily long periods of time (mean residence time of 10000 min). This extended residence time is similar to that displayed by native macaque butyrylcholinesterase (9950 min), which is the prevalent cholinesterase form in the circulation of adult macaques.
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Orlova, Nina, Mark H. Fogg, Angela Carville, and Fred Wang. "Antibodies to Lytic Infection Proteins in Lymphocryptovirus-Infected Rhesus Macaques: a Model for Humoral Immune Responses to Epstein-Barr Virus Infection." Clinical and Vaccine Immunology 18, no. 9 (2011): 1427–34. http://dx.doi.org/10.1128/cvi.05126-11.

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ABSTRACTHumoral immune responses to rhesus lymphocryptovirus (rhLCV) lytic infection proteins were evaluated in the rhesus macaque animal model for Epstein-Barr virus (EBV) infection. We found a hierarchy of humoral responses to 14 rhLCV lytic infection proteins in naturally infected rhesus macaques, with (i) widespread and robust responses to four glycoproteins expressed as late proteins, (ii) frequent but less robust responses to a subset of early proteins, and (iii) low-level responses to immediate-early proteins. This hierarchy of humoral responses was similar to that reported for EBV-infected humans, with the notable exception of the response to rhBARF1. Serum antibodies to rhBARF1 were frequently detected in healthy rhLCV-infected macaques, but in humans, anti-BARF1 antibodies have been reported primarily in patients with EBV-positive nasopharyngeal carcinoma (NPC). The macaque data accurately predicted that serum antibodies against BARF1 are a normal response to EBV infection when human serum samples are analyzed. The rhesus macaque animal provides a unique perspective on humoral responses to EBV infection in humans and can be a valuable model for EBV vaccine development.
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Dudley, Dawn M., Matthew T. Aliota, Emma L. Mohr, et al. "Using Macaques to Address Critical Questions in Zika Virus Research." Annual Review of Virology 6, no. 1 (2019): 481–500. http://dx.doi.org/10.1146/annurev-virology-092818-015732.

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Zika virus (ZIKV) and nonhuman primates have been inextricably linked since the virus was first discovered in a sentinel rhesus macaque in Uganda in 1947. Soon after ZIKV was epidemiologically associated with birth defects in Brazil late in 2015, researchers capitalized on the fact that rhesus macaques are commonly used to model viral immunity and pathogenesis, quickly establishing macaque models for ZIKV infection. Within months, the susceptibility of pregnant macaques to experimental ZIKV challenge and ZIKV-associated abnormalities in fetuses was confirmed. This review discusses key unanswered questions in ZIKV immunity and in the pathogenesis of thecongenital Zika virus syndrome. We focus on those questions that can be best addressed in pregnant nonhuman primates and lessons learned from developing macaque models for ZIKV amid an active epidemic.
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Dissertations / Theses on the topic "Rhesus macaque"

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Talmi, Sydney. "The Rhesus Macaque Corticospinal Connectome." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/cmc_theses/2087.

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The corticospinal tract (CST), which carries commands from the cerebral cortex to the spinal cord, is vital to fine motor control. Spinal cord injury (SCI) often damages CST axons, causing loss of motor function, most notably in the hands and legs. Our preliminary work in rats suggests that CST circuitry is complex: neurons whose axons project to the lower cervical spinal cord, which directly controls hand function, also send axon collaterals to other locations in the nervous system and may engage parallel motor systems. To inform research into repair of SCI, we therefore aimed to map the entire projection pattern, or “connectome,” of such cervically-projecting CST axons. In this study, we mapped the corticospinal connectome of the Rhesus macaque - an animal model more similar to humans, and therefore more clinically relevant for examining SCI. Comparison of the Rhesus macaque and rat CST connectome, and extrapolation to the human CST connectome, may improve targeting of treatments and rehabilitation after human SCI. To selectively trace cervically-projecting CST motor axons, a virus encoding a Cre-recombinase-dependent tracer (AAV-DIO-gCOMET) was injected into the hand motor cortex, and a virus encoding Cre-recombinase (AAV-Cre) was injected into the C8 level of the spinal cord. In this intersectional approach, the gCOMET virus infects many neurons in the cortex, but gCOMET expression is not turned on unless the nucleus also contains Cre-recombinase, which must be retrogradely transported from axon terminals in the C8 spinal cord. Thus, gCOMET is only expressed in neurons that project to the C8 spinal cord, and it proceeds to fill the entire neuron, including all axon collaterals. Any gCOMET-labeled axon segments observed in other regions of the nervous system are therefore collaterals of cervically-projecting axons. gCOMET-positive axons were immunohistochemically labeled, and axon density was quantified using a fluorescence microscope and Fiji/ImageJ software. Specific regions of interest were chosen for analysis because of their known relevance in motor function in humans, and for comparison to results of a similar study in rats. Results in the first monkey have revealed both similarities and differences between the monkey and rodent CST connectome. Analyses of additional monkeys are ongoing. The final results will provide detailed information about differences between rodent and primate CST, will serve as a baseline for examining changes in the CST connectome after SCI, and will provide guidance for studies targeting treatment and functional recovery after SCI.
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Howard, Wendy Anne. "{461} cell dissemination and immunoglobulin genes in the Rhesus macaque." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412906.

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Nichols, Stephanie. "Analysis of Oocyte Quality in the Rhesus Macaque (Macaca mulatta)." ScholarWorks@UNO, 2007. http://scholarworks.uno.edu/td/1078.

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Many primate populations face the threat of extinction due to habitat loss, intensive agriculture, hunting for meat, the pet trade and/or use in traditional medicines. An alternative approach to in situ conservation includes gene banking and the use of assisted reproductive technologies (ART), such as oocyte in vitro maturation (IVM) and in vitro fertilization (IVF). Although many of these 'high-tech' solutions have not yet been proven viable for pragmatic wildlife conservation, basic research and development of these emerging tools can provide necessary information needed to optimize these techniques and institute ART as a routine practice in conservation efforts. A severely limiting factor in the successful application of ARTs is the availability of mature developmentally competent oocytes. Oocyte maturation involves many nuclear and cytoplasmic factors, which can be affected by maturation conditions and female age. In vitro maturation does not have the same success rate across species studied. In primates especially, IVM oocytes exhibit reduced developmental capacity upon fertilization when compared to in vivo matured (IVO) oocytes. This study aimed to investigate possible causes of reduced developmental capacity of primate IVM oocytes using the rhesus macaque (Macaca mulatta) as a model. Research efforts included investigation of ovarian senescence, oocyte karyotype and spindle morphology, and establishment of an optimal sperm cryopreservation protocol for use in IVF. Histological examination of the rhesus ovary demonstrated an age-related pattern of follicle depletion similar to that described in the human ovary. Oocyte karyotype analysis revealed a significant effect of IVM on the frequency of hyperhaploidy. In addition, immunostaining and confocal microscopy demonstrated a significant increase of anomalous chromosome congression on the oocyte metaphase II spindle equator in relation to IVM and donor female age. These results indicate that IVM can produce serious, if not lethal consequences for embryo development. This study presents baseline data on ovarian aging in the rhesus macaque and aspects of nuclear maturation during macaque IVM that may contribute to the design of primate oocyte recovery plans. Implementation of either of two sperm cryopreservation methods originally developed for rhesus and vervet monkeys will aid future investigation of the developmental capacity of IVM oocytes.
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Ottolini, Barbara. "Evolution of copy number variation in the rhesus macaque β-defensin region". Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/28961.

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Beta defensins are multifunctional secreted short peptides rapidly evolving in mammals. They present antibacterial and antiviral action in many species and possess immune cell signal activity, constituting a link between innate and adaptive immunity. In humans the β-defensin region is known to be copy number variable (CNV) and contains seven genes repeated as a block, with a diploid copy number between 1 and 12 and an approximate repeat length of 240kb but the extent and nature of CNV in other mammals remains poorly known. The rhesus macaque (Macaca mulatta) is the most widespread non-human primate, hence constituting a good model to study adaptation and its divergence time from the human lineage (~25MYA) presents enough sequence diversity to investigate mechanisms of copy number variation and evolution. Its genome has been sequenced, although there is poor assembly quality in repeated segments such as the β-defensin region. This thesis studied the genomic architecture of the rhesus macaque β-defensin region using a variety of methods (aCGH, PCR-based methods, BAC library screening and cytogenetic approaches) with the aim of overcoming the limitations of the assembly and of determining the copy number distribution for this region. Evidences are here provided that only the region containing DEFB2L gene (orthologue to human DEFB4) is CNV, with a diploid copy number between 2 and 11, with a repeat size of 20kb, while the rest of the cluster shows no variation. This could represent a case where the same area prone to copy number variation evolved to present a different copy number unit structure in two different lineages, still converging in the same copy number distribution for the possible effect of similar functional constraints. Also, evidences of non-synonymous variations are shown for the DEFB2L gene, suggestive of the different evolutionary pattern followed by the rhesus macaque β-defensin region.
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Sorenson, Andrea Nichole. "Predicting Alcohol Consumption in Adolescent Rhesus Macaques (Macaca mulatta)." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4186.

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Numerous studies show that a low level of response to the intoxicating effects of alcohol is considered a risk factor for future alcoholism. However, assessing this sensitivity usually requires administering a controlled dose of alcohol, which has a number of inherent problems. Early observations in our lab suggest that the response to anesthetics that show cross tolerance with alcohol, like ketamine, are blunted in nonhuman primates at risk for high alcohol intake, and may be a viable measure of future alcohol consumption. This study was designed to test potential predictors of future alcohol consumption using the change in ketamine across repeated exposures (i.e., tolerance). In addition, potential mediating factors of alcohol consumption, including early temperament and behavior, were assessed. Subjects were 16 three-year-old, alcohol naïve rhesus macaque males raised by their biological mothers. Ketamine Exposure-Each subject was exposed to three 10.0 mg/kg intramuscular doses of ketamine. The time from injection to recovery from anesthetic was recorded for each dose, to be used as a measure of subject's sensitivity and developed tolerance. Alcohol Intake Assessment-Two weeks after the final ketamine dose, subjects were allowed ad libitum access to a palatable 8.4% alcohol solution for two-hours a day, five days a week, for six weeks. During the Two-Choice phase of testing, subjects were simultaneously given ad libitum access to the 8.4% alcohol solution and to a sweetened solution for two-hours a day, five days a week, for four weeks. Solution consumption was recorded daily and averaged across the weeks for each phase of alcohol testing. Temperament and Behavior-As infants, all subjects participated in a bio-behavioral assessment (BBA), when they were between 90 and 120 days of age. Data collected during the BBA on subjects' temperament (Vigilance, Gentleness, Confidence, and Nervousness) and Behavior (Activity and Emotionality) were used in analyses. Results showed a relationship between the tolerance developed between ketamine doses and average alcohol consumption during the Alcohol-Only phase (r = 0.61, R2 = 0.372, F (1,14) = 8.300, p = 0.012). Average alcohol consumption during the Alcohol-Only phase was also related to ratings of Confidence (r = 0.499, R2=0.249, F(1,14)=4.647, p = 0.049), Activity (Day 1: r = 0.503, R2 = 0.253, F(1,14) = 4.732, p = 0.047; Day 2: r = 0.455, R2 = 0.207, F(1,14) = 3.652, p = 0.077), and Emotionality (r = 0.466, R2 = 0.217, F(1,14) = 3.885, p=0.069). The results of this study suggest that change in ketamine recovery time and early life temperament and behaviors may be measures of future risk for alcohol abuse disorders. This data is limited by the small sample size and future study is necessary to further tease out the relationships between these variables and alcohol consumption.
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Brasó-Vives, Marina 1990. "Evolution and genomic impact of duplications : human and rhesus macaque genomes as case studies." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/665993.

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La duplicació és el principal mecanisme de formació de nou material genètic i d'innovació funcional. Entendre com les duplicacions sorgeixen, evolucionen, co-evolucionen i engendren noves funcions és essencial. Aquesta tesi recull les meves contribucions a aquest objectiu. Investigo la recombinació responsable de la co-evolució dels duplicats: conversió gènica entre loci (IGC). Específicament, exploro com l'IGC i la recombinació per entrecreuament interactuen; com la dependència de l'IGC de la similitud entre duplicats influencia la seva co-evolució i com el col·lapse de duplicats en el muntatge de genomes altera proves estadístiques. També caracteritzo la diversitat de les duplicacions altament similars del genoma humà per aclarir els seus mecanismes de duplicació, moment d'aparició i contribució a la formació de nous gens. Finalment, descric les regions duplicades i variants en nombre de còpia del genoma del macaco rhesus i hi identifico diferències gèniques en nombre de còpies de rellevància funcional amb el genoma humà.<br>Duplication is the main mechanism for the formation of new genetic material and functional innovation. Understanding the way duplications arise, evolve, co-evolve and give rise to new functions is essential. In this thesis, I present my contributions to the pursuit of this goal. I investigate the recombination process driving the concerted evolution of duplicates: interlocus gene conversion (IGC). In particular, I explore how IGC and crossover interplay, how IGC dependence on sequence similarity between duplicates influences their concerted evolution, and how IGC and the collapse of duplications in genome assemblies alters test statistics. In addition, I characterize the diversity of highly similar duplications in the human genome to elucidate their duplication mechanisms, their time of appearance and their contribution to the formation of new genes. Finally, I describe the duplicated and copy-number variant regions in the rhesus macaque genome and identify therein gene copy-number differences of functional relevance with humans.
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GRAILLE, CLOTILDE. "Capacites d'attention et sommeil chez le macaque rhesus : etude en laboratoire et en microgravite." Paris 6, 1997. http://www.theses.fr/1997PA066364.

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La premiere partie de ce travail decrit les niveaux d'attention chez le macaque rhesus pendant l'execution d'une tache visuo-motrice presentant divers degres de difficulte en laboratoire. L'analyse du comportement de l'animal correlee a celle de son electrocorticogramme (ecog) recueilli dans l'aire parietale posterieure (aire 5 de brodmann), par des electrodes implantees a demeure, a montre chez celui-ci des relations significatives des rythmes beta avec l'etat attentionnel de l'animal. L'attention diffuse vers l'environnement experimental a ete illustree par une dispersion des frequences, l'attention focalisee sur la tache qu'il effectue, par une concentration des frequences autour de 20-30 hz. Des enregistrements simultanes dans le cortex occipital a montre l'apparition de rythmes rapides visuels (autour de 18 hz) pendant la focalisation attentive et des rythmes dans la bande alpha (autour de 10 hz) correspondant a des stades de relaxation des sujets. Dans la deuxieme et la troisieme partie, nous avons applique cette methode ecog a l'etude des capacites d'attention et du sommeil chez 4 jeunes macaques rhesus avant, pendant et apres des vols spatiaux biocosmos dans lesquels les sujets sont leur propre temoin. L'analyse visuelle et automatisee des traces des premiers jours de vol ont temoigne d'une diminution considerable des taux de rythmes beta pendant l'execution d'une tache visuo-motrice accompagnee entre-autre d'une modification de la distribution de leurs frequences instantanees. Des rythmes lents ont ete notes pendant des phases importantes du test, signant un retrait d'attention. L'organisation structurale et temporelle du sommeil nocturne a ete egalement modifiee : augmentation des eveils et du sommeil leger, diminution du sommeil profond, augmentation du sommeil paradoxal, inversion de la distribution des taux nocturnes de sommeil lent et profond. Apres quelques jours, le sujet est redevenu plus attentif bien que les rythmes lents aient regresse lentement. Pendant la nuit, le sommeil paradoxal a diminue. Differentes hypotheses ont ete proposees pour expliquer ces troubles attentionnels et hypniques, en particulier l'effet conjugue de la microgravite et d'une tension emotionnelle.
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Herrman, Marissa. "Neutralizing Antibodies to Epstein Barr Virus in the Rhesus Macaque Animal Model and in Humans." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845409.

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Epstein-Barr virus (EBV) is associated with a number of human diseases and does not have a vaccine. It is believed that neutralizing antibodies are an important immune effector for an EBV vaccine, but it is unknown whether serum neutralizing antibodies can alter EBV infection through the oral mucosa. The studies presented in this dissertation were designed 1) to adapt the rhesus macaque animal model to allow testing of neutralizing antibodies in a biologically relevant system and 2) to better define the neutralizing antibody response of EBV infected humans. Infection of rhesus macaques with the EBV related lymphocryptovirus, rhLCV, provides an accurate model system for studying EBV, but there were two hurdles that needed to be overcome before neutralizing antibodies could be tested in this model. First, there are no neutralizing antibodies specific to rhLCV and we found that a potent EBV neutralizing antibody, 72A1, did not cross-neutralize rhLCV. Second, murine monoclonal antibodies are inherently immunogenic in macaques and induce anti-antibody responses that limit their utility. To create a virus sensitive to 72A1 neutralization, the major membrane glycoprotein of rhLCV with replaced with EBV gp350. The data presented here show that this chimeric virus can use EBV gp350 to support entry into macaque cells in vitro and following oral inoculation of rhesus macaques. To reduce the immunogenicity of the murine antibodies, “rhesusized” antibody variants were generated and shown to retain antigen specificity. The combination of this novel, chimeric virus and the “rhesusized” antibodies will now allow testing of neutralizing antibodies in the macaque model. Although multiple EBV glycoproteins have been shown to induce neutralizing antibodies in mice, studies of the human neutralizing antibody response have been narrowly focused on a single antibody binding epitope on gp350. Here we show that antibodies binding to this epitope do not represent all EBV neutralizing activity in human sera. Additionally, these data suggest that the neutralizing response is much broader than appreciated, with multiple glycoproteins inducing EBV neutralizing antibodies. Accurately defining the repertoire of viral glycoproteins targeted by human neutralizing antibodies can inform us of the naturally immunogenic proteins that may make good vaccine immunogens.<br>Biology, Molecular and Cellular
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Jin, William. "Orexin axon density and bouton quantification in the aging rhesus macaque thalamus: a novel methodology." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12127.

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Thesis (M.A.)--Boston University<br>Sleep fragmentation and disturbances of normal circadian rhythms are inherent in the aging human population. The rhesus macaque (Mucaca mulatta) exhibits similar disruption in sleep patterns and is a useful model to study these disturbances. Orexin is an excitatory neuropeptide that has been implicated in the regulation of wakefulness and alertness. Specifically, it has projections from its neuronal bodies in the lateral and perifornical hypothalamus to various forebrain and brainstem regions that control arousal state. One of the regions of high innervation by these orexigenic neurons is the thalamus. This study used a semi-quantitative means to determine if there are age dependent changes in Orexin innervation in the thalamus. There was a general trend of decreasing axon density when analyzed with a novel semi-quantitative method (r = -0.515, p = 0.024, df = 17) and approached significance when assessed with a previously published method (r = -0.454, p = 0.0509, df = 17), indicating a decrease with age. Additionally, there was no significant decrease in unilateral bouton counts iii when examined with age using either method. Although the findings in this study point to an age-related decrease in axon terminals, further research should examine the total orexigenic positive content in the thalamus to explain why bouton counts do not seem to change.
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Chakrabarti, Lisa. "Le siv, un lentivirus simien associe au sida chez le macaque rhesus : organisation genetique, tropisme neurologique." Paris 7, 1991. http://www.theses.fr/1991PA077146.

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La determination de la sequence nucleotidique du sivmac a montre que ce virus presente l'organisation genomique caracteristique d'un lentivirus, et qu'il est remarquablement proche du hiv-2, avec lequel il partage une homologie nucleotidique de 75%. La proximite genetique du sivmac et du hiv-2 suggere une parente evolutive entre ces deux virus et pose la question d'une origine simienne pour les virus du sida humain. Le gene d'enveloppe du sivmac presente la caracteristique d'etre tronque par un codon non-sens de la partie codant pour le domaine cytoplasmique de l'enveloppe. Lorsque le codon non-sens tag a ete remplace par un codon glutamine cag, le virus a presente une capacite de replication reduite en lignee lymphoide. Un phenomene de contre-selection de l'expression du domaine cytoplasmique a ete mis en evidence in vitro. Par contre, l'analyse par pcr a revele que, chez les macaques infectes, le domaine cytoplasmique est exprime, suggerant que cette region est necessaire au developpement de l'infection in vivo. Dans la derniere partie du travail, nous avons etudie les etapes precoces de l'encephalopathie induite par le siv. L'infection du systeme nerveux central s'est revelee etre un evenement precoce, le virus pouvant etre detecte par hybridation in situ des le 7#e jour suivant l'inoculation. Les infiltrats monocytaires representent la principale source de virus dans le snc. Nous avons observe une activation des macrophages et des cellules microgliales, ce qui suggere l'existence d'un mecanisme immunopathologique pouvant favoriser la dissemination initiale du virus dans le snc
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Books on the topic "Rhesus macaque"

1

Fooden, Jack. Systematic review of the rhesus macaque, Macaca mulatta (Zimmermann, 1780). Field Museum of Natural History, 2000.

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Fooden, Jack. Comparative review of Fascicularis-group species of macaques (Primates: Macaca). Field Museum of Natural History, 2006.

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Gahunia, Harpal Kaur. Osteoarthritis in rhesus macaque: Assessment of cartilage matrix quality by magnetic resonance imaging. National Library of Canada = Bibliothèque nationale du Canada, 1993.

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Wang, Qian, ed. Bones, Genetics, and Behavior of Rhesus Macaques. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-1046-1.

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Reinhardt, Viktor. Environmental enhancement for caged rhesus macaques: A photographic documentation. Animal Welfare Institute, 1998.

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1950-, Rawlins Richard G., and Kessler Matt J. 1947-, eds. The Cayo Santiago macaques: History, behavior, and biology. State University of New York Press, 1986.

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Reinhardt, Viktor. Environmental enrichment for caged rhesus macaques: A photographic documentation and literature review. 2nd ed. Animal Welfare Institute, 2001.

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United States. National Aeronautics and Space Administration., ed. Light and gravity effects on circadian rhythms of rhesus macaques: Final technical report, NAG2-801. National Aeronautics and Space Administration, 1997.

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Rhesus Macaque Fact: RHESUS MACAQUE Fact for Girl Age 1-10 RHESUS MACAQUE Fact for Boy Age 1-10 Facts about All about RHESUS MACAQUE. Independently Published, 2021.

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Schafer, Jamie Lynn. Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides. 2014.

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Book chapters on the topic "Rhesus macaque"

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Ahuja, Neel. "Macaques and Biomedicine: Notes on Decolonization, Polio, and Changing Representations of Indian Rhesus in the United States, 1930–1960." In The Macaque Connection. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3967-7_5.

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Hoffman, Christy L., and Dario Maestripieri. "Costs of Reproduction Among Rhesus Macaque Females on Cayo Santiago." In Bones, Genetics, and Behavior of Rhesus Macaques. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1046-1_10.

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Ramsey, Cathy, and Carol Hanna. "In Vitro Culture of Rhesus Macaque (Macaca mulatta) Embryos." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9566-0_23.

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Tang, Qingquan, Baojian Li, Martin Woodle, and Patrick Y. Lu. "Application of siRNA Against SARS in the Rhesus Macaque Model." In Methods in Molecular Biology™. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-191-8_11.

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Wallen, Kim. "Prenatal Steroid Hormones and Sex Differences in Juvenile Rhesus Macaque Behavior." In Gender and Sexuality Development. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84273-4_2.

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Lange, Frederik J., Stephen M. Smith, Mads F. Bertelsen, et al. "Multimodal MRI Template Creation in the Ring-Tailed Lemur and Rhesus Macaque." In Biomedical Image Registration. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50120-4_14.

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Capitanio, John P. "Hematology and Serum Chemistry Reference Values for Rhesus Macaque (Macaca mulatta) Infants." In Nursery Rearing of Nonhuman Primates in the 21st Century. Springer US, 2006. http://dx.doi.org/10.1007/978-0-387-25640-5_26.

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Roberts, J. A. "The Aged Rhesus Macaque in Neuroscience Research: Importance of the Nonhuman Primate Model." In Interdisciplinary Topics in Gerontology. KARGER, 2002. http://dx.doi.org/10.1159/000061464.

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Chiu, Kevin B., Kim M. Lee, Katelyn N. Robillard, and Andrew G. MacLean. "A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9068-9_19.

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Brenner, R. M., O. D. Slayden, T. Koji, et al. "Hormonal Regulation of the Paracrine Growth Factors HGF and KGF in the Endometrium of the Rhesus Macaque." In The Endometrium as a Target for Contraception. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-662-10323-4_2.

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Conference papers on the topic "Rhesus macaque"

1

Ashar, Muhammad Sultonun Arifin Ali, Parichat Prommana, Tana Taechalertpaisarn, and Chairat Uthaipibull. "Identification of Plasmodium infection in cynomolgus macaque and rhesus macaque monkeys in Thailand forests." In 12TH INTERNATIONAL SEMINAR ON NEW PARADIGM AND INNOVATION ON NATURAL SCIENCES AND ITS APPLICATIONS (12TH ISNPINSA): Contribution of Science and Technology in the Changing World. AIP Publishing, 2024. http://dx.doi.org/10.1063/5.0218055.

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Wang, Fan, Chunfeng Lian, Jing Xia, et al. "Construction of spatiotemporal infant cortical surface atlas of rhesus macaque." In 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018). IEEE, 2018. http://dx.doi.org/10.1109/isbi.2018.8363671.

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Xu, Yong, Tigran Gevorgyan, Douglas S. Pfeil, Daniel C. Lee, and Randall L. Barbour. "An Anatomical Atlas-Based Method for fNIRS Imaging of the Rhesus Macaque." In Biomedical Optics. OSA, 2012. http://dx.doi.org/10.1364/biomed.2012.bsu3a.88.

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Fu, Xiao-Wei, Cheng-Zhen Guo, Peng-Cheng Li, Dan-Zhou Yang, and Ying Zhang. "The Identification of Default Mode Network in Rhesus Macaque Using Resting-State fMRI." In 2017 2nd International Conference on Biological Sciences and Technology (BST 2017). Atlantis Press, 2018. http://dx.doi.org/10.2991/bst-17.2018.13.

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Fu, Zeqing, Yiyi Deng, Xuyang Bai, et al. "CUDA-Based Real-Time Bimanual Gestures Interaction with the Rhesus Macaque Brain MRI Data." In 2015 International Conference on Virtual Reality and Visualization (ICVRV). IEEE, 2015. http://dx.doi.org/10.1109/icvrv.2015.49.

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Fu, Zeqing, Yiyi Deng, Xin Jia, Bin Gao, Xiaoming Zhu, and Yanlin Luo. "Automated brain extraction and associated 3D inspection layers for the Rhesus macaque MRI datasets." In VRCAI '16: The 15th International Conference on Virtual-Reality Continuum and its Applications in Industry. ACM, 2016. http://dx.doi.org/10.1145/3013971.3013984.

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Rosado-Mendez, Ivan M., Laura Castaneda-Martinez, Chrysanthy Ikonomidou, James A. Zagzebski, and Timothy J. Hall. "Coherent Ultrasound Scattering in the Young Rhesus Macaque Brain: Effects of Exposure to Anesthetics." In 2018 IEEE International Ultrasonics Symposium (IUS). IEEE, 2018. http://dx.doi.org/10.1109/ultsym.2018.8580203.

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Alapati, Raghava, Kelly Goff, Hans-Michael Kubisch, and Ram V. Devireddy. "Comparative Freezing Response of Ejaculated and Epididymal Rhesus Monkey Sperm." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192692.

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In the present study, we report the effects of cooling ejaculated and epididymal rhesus monkey (Macaca mulatta) sperm in the presence of extracellular. Water transport data during freezing of ejaculated and epididymal sperm cell suspensions were obtained at a cooling rate of 20 °C/min in the absence of any cryoprotective agents. Additional water transport data was obtained from ejaculated sperm at a cooling of 5 °C/min without CPAs and at 20 °C/min in the presence of 0.7M of glycerol, as well. Using previously published values, the bovine sperm cell was modeled as a cylinder of length 73.83 μm and a radius of 0.32 μm with an osmotically inactive cell volume, Vb, of 0.772Vo, where Vo is the isotonic cell volume. The subzero water transport response is analyzed to determine the variables governing the rate of water loss during cooling of bovine spermatozoa, i.e. the membrane permeability parameters (reference membrane permeability, Lpg and activation energy, ELp). The predicted best-fit permeability parameters ranged from, Lpg = 0.0023 to 0.0029 μm/min-atm and ELp = 10.6 to 45.5 kcal/mol. The subzero water transport response and consequently the subzero water transport parameters are not significantly different between the ejaculated and epididymal macaque spermatozoa under corresponding cooling conditions.
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Spindel, E. R., L. Shorey-Kendrick, A. Crosland, et al. "Prenatal Delta-9-tetrahydrocannabinol Exposure Adversely Impacts Lung Development, Function, and Volume in Rhesus Macaque Offspring." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6227.

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Rosado-Mendez, Ivan M., Lindsey C. Drehfal, Andrew P. Santoso, et al. "Notice of Removal: Biological factors affecting shear wave speed measurements in the Rhesus macaque non-pregnant cervix." In 2017 IEEE International Ultrasonics Symposium (IUS). IEEE, 2017. http://dx.doi.org/10.1109/ultsym.2017.8092031.

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Reports on the topic "Rhesus macaque"

1

Fogle, Gertrude. The effect of chronic post-natal protein deprivation on the social interaction of the rhesus macaque. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.473.

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McKee, Kelly T., Oro Jr., Kuehne Julio G., Spisso Anna I., Mahlandt Joan A., and Bill G. Safety and Immunogenicity of a Live-Attenuated Junin (Argentine Hemorrhagic Fever) Vaccine in Rhesus Macaques. Defense Technical Information Center, 1993. http://dx.doi.org/10.21236/ada265506.

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