Dissertations / Theses: 'Rheumatoid arthritis Rheumatoid arthritis Osteoarthritis Osteoarthritis Hydrocortisone'

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Huyser, Bruce A. "The effects of an acute laboratory stressor on cortisol and sympathetic response in individuals with rheumatoid arthritis and osteoarthritis controls /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9842540.

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Luukkonen, J. (Jani). "Osteopontin and osteoclasts in rheumatoid arthritis and osteoarthritis." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526223643.

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Abstract Rheumatoid arthritis and osteoarthritis are two chronic joint diseases, which cause two of the largest socioeconomical burdens among all joint diseases according to the World Health Organization. Both diseases are associated with changes in bone structure and bone cell, especially osteoclast, function. The etiology or pathogenesis of these diseases are not completely understood. Traditionally, osteoarthritis is seen as a disease resulting from mechanical wear of cartilage and bone, and rheumatoid arthritis as an autoinflammatory disease of synovial tissue. However, also in osteoarthritis chronic inflammation is present in synovial tissue, and in rheumatoid arthritis large changes in bone structure are seen. The field of study focusing on this connection between inflammation and bone is called osteoimmunology and it can explain many features of these chronic diseases linking joint health to disturbances in bone homeostasis. Here, the study focused on the function of osteoclasts in normal and pathological environments, and on the factors that have an effect on bone resorption, with a special emphasis on the protein osteopontin. Samples of synovial fluid and serum from rheumatoid arthritis and osteoarthritis patients were analyzed for factors affecting osteoclasts, and in vitro cell cultures of human derived osteoclasts were used to analyze osteoclast function in normal and pathological environment. The phosphorylation of osteopontin was found to be increased in rheumatoid arthritis, along with multiple other inflammatory factors that also affect osteoclasts, such as IL-6, IL-8 and VEGF. Osteoclast cell cultures showed how the use of different patient samples significantly affected osteoclastogenesis, due to so-called inflammatory osteoclastogenesis. Additionally, we show that osteoclasts deposit osteopontin into the resorption lacunae during bone resorption. Based on the results, the inflammatory component present in both osteoarthritis and rheumatoid arthritis significantly affects osteoclast function, and its further study in the future may reveal new therapeutic possibilities. Especially the new discoveries of osteopontin’s role in normal osteoclast function and its changes seen between osteoarthritis and rheumatoid arthritis may prove to have therapeutic potential
Tiivistelmä Nivelreuma ja nivelrikko ovat kroonisia nivelsairauksia, jotka Maailman terveysjärjestön (WHO) mukaan aiheuttavat eniten sosioekonomista haittaa. Molemmissa sairauksissa luiden rakenteessa ja luusolujen, erityisesti osteoklastien, toiminnassa tapahtuu muutoksia. Kummankaan taudin etiologiaa tai patogeneesiä ei täysin tunneta. Perinteisesti ajatellaan, että nivelrikko johtuu rusto- ja luukudoksen mekaanisesta kulumisesta ja nivelreuma nivelkalvon autoinflammatoorisesta tulehduksesta. Kuitenkin nivelrikossa nähdään myös selkeä nivelkalvon krooninen tulehdus ja nivelreumassa suuria luun rakenteen muutoksia. Tutkimusala, joka tutkii tulehduksen ja luun yhteyttä, on nimeltään osteoimmunologia. Tässä väitöskirjassa tutkitaan osteoklastien toimintaa ja niihin vaikuttavia tekijöitä, erityisesti proteiini osteopontiinia, normaalissa ja tautiympäristössä. Analysoin osteoklasteihin vaikuttavia tekijöitä nivelrikko- ja nivelreumapotilaiden näytteistä sekä osteoklastien toimintaa soluviljelmissä. Soluviljelmissä käytettiin nivelreuma- ja nivelrikkopotilaiden näytteitä mahdollisimman totuudenmukaisen ympäristön luomiseksi osteoklasteille. Tutkimuksessa osoitettiin, kuinka osteopontiinin fosforylaatio on lisääntynyt nivelreumapotilaiden nivelnesteessä. Myös useiden muiden osteoklasteihin vaikuttavien tekijöiden, kuten IL-6:n, IL-8:n ja VEGF:n, havaittiin lisääntyneen nivelreumassa. Osteoklastien soluviljelmissä havaittiin selkeät erot siinä, miten eri potilasnäytteet vaikuttavat osteoklasteihin ja erityisesti tulehduksen aiheuttamaan osteoklastien syntyyn. Osoitan myös, miten osteoklastit erittävät osteopontiinia luunhajotuskuoppaan luun hajotuksen aikana. Tutkimustulosten mukaan krooninen tulehdustila nivelrikossa ja nivelreumassa vaikuttaa huomattavasti osteoklastien toimintaan. Uskon, että lisätutkimukset tällä saralla voivat paljastaa uusia hoidollisia mahdollisuuksia. Erityisesti uudet löydökset osteopontiinin roolista osteoklastien toiminnassa sekä muutoksista nivelrikossa ja nivelreumassa vaativat jatkotutkimuksia, jotta proteiinin kliininen merkittävyys saadaan selvitettyä

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Kuliwaba, Julia Suzanne. "Gene expression, bone remodelling, and microdamage in the human proximal femur: a molecular histomorphometric analysis of osteoarthritic bone." Title page, contents and summary only, 2003. http://web4.library.adelaide.edu.au/theses/09PH/09phk956.pdf.

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Whellams, Emma Jane. "The role and regulation of insulin like growth factor binding proteins in arthritis." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324333.

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Walne, Amanda Jayne. "Pyridinium crosslinks in serum and other biofluids in health and disease." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363047.

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Gadher, S. J. "An enzymatic study of cartilage degradation." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234208.

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Bond, Alison P. "The importance of kinins in inflammatory joint diseases." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241214.

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Murata, Koichi. "Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis." Kyoto University, 2013. http://hdl.handle.net/2433/174785.

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Nugraheni, Gesnita. "Managing Medication Regimen: Arthritis Patients' Perception." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1372863682.

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Comee, Laura. "Dietary Patterns and Nutrient Intake of Individuals with Rheumatoid Arthritis and Osteoarthritis in the U.S." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu152112556958269.

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Craps, Davina Denise. "Exploring new research avenues for osteoarthritis and rheumatoid arthritis in palaeopathology : interdisciplinary approaches focusing on methodological techniques." Thesis, Durham University, 2015. http://etheses.dur.ac.uk/11115/.

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This project sought to examine and critically evaluate current methodologies for the analysis and interpretation of osteoarthritis and rheumatoid arthritis within palaeopathology, with reference to clinical research. A compartmental recording method was developed for osteoarthritis and a distinction between degenerative joint changes and osteoarthritis was maintained. This method was applied to the analysis of five Post-Medieval skeletal populations from both rural and urban sites from northern England. An analysis of the pattern and distribution of osteoarthritis and DJC between the sites, including rural versus urban differences, age and sex-specific comparisons, and, where possible, a comparison with contemporaneous sites from southern England was undertaken. A set of diagnostic criteria for rheumatoid arthritis was developed, applied, and tested on potential cases of rheumatoid arthritis within the archaeological record. Given this condition’s scarcity within the palaeopathological context, a wider geographical and temporal analysis was conducted. Results, based on clinical research and differential prevalence rates, indicated that DJC and osteoarthritis should be assessed separately. General rural-urban patterns were similar for DJC, even when compared with age or sex, which was not the case for osteoarthritis. The compartmental approach indicated differential distributions between mobile and stable elements of ball-and-socket and between skeletal elements in hinge joints respectively, which was explained through osteophyte-development and biomechanical analysis. The results were compared with clinical research to explore the impact of degeneration on the daily lives of past individuals, while not relying on activity reconstruction. A foundation for future research on rheumatoid arthritis was created by the development of the set of diagnostic criteria and a visual comparative study of the erosive lesions between palaeopathological cases. Remarkable similarities were found in the expression of erosions in several skeletal elements (ulna, radius and cervical vertebrae). By analysing clinical, palaeopathological and historical information this project concluded that the disease is not of recent origin.

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De, Angelis Gino. "The Dissemination of Clinical Practice Guidelines to Arthritis Health Professionals Using Innovative Strategies." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37802.

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Problem: With an increasing aging Canadian population with chronic diseases such as arthritis, there is an urgent need for health professionals to promote evidence-based arthritis self-management support to their patients. Objective: The overall objective of this thesis was to determine the feasibility of using Facebook as a dissemination strategy for an online evidence-based arthritis self-management program, People Getting a Grip on Arthritis (PGrip), by arthritis health professionals with their patients. Methods: To identify the current evidence and knowledge gaps in regards to the use of innovative dissemination strategies for clinical practice guidelines (CPGs) and social media use for chronic disease self-management among health professionals, two systematic reviews of the literature were conducted. The first systematic review identified research on health professionals’ perceived usability and practice behaviour change of information and communication technologies (ICTs) for the dissemination of CPGs. The second identified research on the perceived usability of social media by health professionals to facilitate chronic disease self-management with their patients. To engage potential knowledge users in the research process, an advisory committee consisting of six arthritis health professional users (two registered nurses, two physiotherapists, and two occupational therapists) was convened to identify barriers and facilitators of using and accessing Facebook as a dissemination strategy for PGrip. The advisory committee was also convened to identify how the PGrip Facebook group page could be tailored to improve usability among arthritis health professionals. A feasibility study of 78 arthritis health professionals was then conducted to determine the feasibility of using Facebook as a dissemination strategy for PGrip among arthritis health professionals to their patients. To guide future research, a protocol for a pilot randomized controlled trial (RCT) was developed that will compare Facebook with an educational website and email to determine which strategy will demonstrate greater perceived usefulness among arthritis health professionals to disseminate the PGrip program with their patients. Results: The findings of the first systematic review revealed that health professionals’ perceived usability and practice behaviour change varies by type of ICT and the heterogeneity and paucity of properly conducted studies did not allow for a clear comparison between studies. The second systematic review revealed that health professionals perceived discussion forums and collaborative projects to be useful social media platforms to facilitate chronic disease self-management with patients. The feasibility study suggested that a Facebook group page can be used as a dissemination strategy for the PGrip program by arthritis health professionals. The Facebook group page was perceived to be usable with patients after two weeks and three months in regards its ease of use and high output quality. Conclusion: The overall research of this thesis provides advanced knowledge on how a Facebook group page as a dissemination strategy for an evidence-based self-management program for patients is perceived by arthritis health professionals. Facebook may provide arthritis health professionals with an additional option of how to best share evidence-based information to allow their patients to successfully self-manage their arthritis. A future pilot RCT is needed to determine whether Facebook is superior to other ICT intervention in regards its perceived usefulness among arthritis health professionals to disseminate the PGrip program with their patients.

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Breckon, Anke. "An investigation of the morphological and mechanical properties of cancellous bone in rheumatoid arthritis and osteoarthritis of the hip." Master's thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/26328.

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Srikesavan, Cynthia. "Task-oriented training with computer gaming in people with rheumatoid arthritis or hand osteoarthritis: A quasi-mixed methods pilot study." BioMedCentral-Trials Journal, 2013. http://hdl.handle.net/1993/30079.

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Background: A computer game based Telerehabilitation platform has been developed to provide a seamless system for hand exercise and assessment in home settings for people with arthritis. The exercise program involves task-oriented training of real life object manipulation tasks performed with computer gaming. The platform will also be integrated with a telemonitoring, computer game based hand function assessment application. Objectives: 1) To determine test-retest reliability and convergent validity of the assessment application protocol in people with rheumatoid arthritis or hand osteoarthritis, 2) To conduct a pilot randomized controlled trial for assessing the feasibility, and therapeutic effects of the task-oriented training compared to conventional hand exercises, and 3) To qualitatively evaluate participants’ experiences on their respective exercise programs. Methods: Performance during three different object manipulation tasks was evaluated by the assessment application protocol on 40 people with arthritis. The performance measures were correlated with other common hand function measures. A six-week pilot randomized trial was conducted on 16 individuals with arthritis. The Arthritis Hand Function Test (AHFT), the Disabilities of Arm, Shoulder and Hand (DASH) questionnaire, exercise compliance and task performance during three object manipulation tasks were the clinical outcomes. Focus group interviews were conducted on seven participants who had before received their home exercise programs. Results: The protocol demonstrated moderate to high test-retest reliability (ICCs between 0.5-0.84) of performance measures. Spearman correlation coefficients (rho) between task performance measures and other measures of hand function were low to moderate (0.4 < rho < 0.5 to 0.7). The pilot trial was not successful in terms of participant recruitment but demonstrated feasibility of study procedures, resources, and management. Except for two dexterity sub-scales of the AHFT, there were no significant differences in other clinical measures. Exercise compliance was >85% in both groups. The qualitative study provided initial evidence on the appropriateness, acceptance, perceived benefits, and a few practical difficulties in performing each exercise program. Conclusions: The hand function assessment application warrants validation in a variety of object manipulation tasks and in different patient populations. In order to proceed to a full-fledged trial, additional recruitment strategies, and revisions in the inclusion criteria must be considered.
February 2015

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Ishikawa, Hiroshi. "Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis." Kyoto University, 2000. http://hdl.handle.net/2433/180881.

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MacDonald, Daniel Francis. "Gene expression in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients Novel expression of IL-19 and IL-22 by fibroblasts." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26705.

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Our objective was to study gene expression related to cytokines and cytokine receptors in FLS. We were looking for any previously unidentified cytokines and receptors that may play a role in the pathogenesis of RA. Using a microarray-based approach to identify any potential expressed cytokine genes we found that two pro-inflammatory cytokines belonging to the IL-10 family of cytokines, IL-19 and IL-22, are constitutively expressed in cultured FLS, and this expression was independent of length of culture. The other work in this thesis focused on identifying potential cytokine receptors expressed in FLS and other cells. From these studies, it was identified that FLS do not express membrane bound receptors for IL-19 or other IL-10 family members, but they are capable of expressing IL-22BP, a non membrane bound soluble form of the IL-22 receptor. This is the first indication that fibroblasts are capable of transcribing this gene. The work presented in this thesis has addressed gene expression in FLS and the findings may prove to be important in understanding maintenance of inflammation in RA. The finding that FLS can transcribe mRNA for IL-19 and IL-22, may indicate that these cells are important sources of these pro-inflammatory cytokines in vivo. The receptor studies may also prove to be useful in expanding the knowledge of receptor expression in FLS. (Abstract shortened by UMI.)

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Bradlow, Anthony. "Clinical and laboratory studies into possible relationships between alcohol and musculoskeletal disorders, with emphasis on rheumatoid arthritis, primary osteoarthritis of the hip and Dupuytren's contracture." Thesis, University of Cape Town, 1985. http://hdl.handle.net/11427/25598.

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Glimm, Anne-Marie [Verfasser]. "Analysis of distribution and severity of inflammation in patients with osteoarthritis and rheumatoid arthritis by ICG-enhanced fluorescence optical imaging and musculoskeletal ultrasound / Anne-Marie Glimm." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1139255304/34.

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Gaignaux, Amélie. "Développement et évaluation de nouvelles formulations à libération prolongée à base de microparticules de PLGA en vue d'une administration intra-articulaire dans le traitement de pathologies inflammatoires." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209388.

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L’arthrose et l’arthrite rhumatoïde sont deux pathologies articulaires caractérisées par la dégradation du cartilage articulaire, subséquente à la production de divers médiateurs inflammatoires. Le traitement de ces pathologies se limite généralement à soulager le patient des épisodes douloureux et inflammatoires et à améliorer sa qualité de vie. Dans le cas de l’arthrose, peu de traitements permettent d’enrayer significativement l’évolution de la dégradation du cartilage et donc de la maladie. Par contre, l’arthrite rhumatoïde peut être efficacement ralentie grâce à l’administration de certaines molécules. Néanmoins, ces traitements n’ont généralement montré qu’une efficacité à court-terme, requérant une administration fréquente. L’objectif de ce travail repose donc sur l’élaboration de nouvelles options thérapeutiques permettant de réduire la fréquence d’administration ainsi que les effets indésirables des traitements actuels. La délivrance de molécules en intra-articulaire associée à une libération prolongée offre l’avantage d’exposer les sites directement impliqués dans l’évolution de la maladie à une ou plusieurs molécules efficaces contre l’inflammation et la douleur, et aidant à la régénération du cartilage, durant plusieurs semaines, voire des mois.

Des microparticules de PLGA chargées en clonidine ou en bétaméthasone ont donc été optimisées afin d’obtenir des efficacités d’encapsulation appréciables (clonidine HCl :EE ≈ 20% ;dipropionate de bétaméthasone :EE ≈ 70%), une taille adaptée à l’administration intra-articulaire (12 – 38 µm) et une libération de la molécule s’échelonnant sur 5 à 8 semaines. La libération prolongée de la clonidine implique des mécanismes de diffusion de la molécule ainsi que de dégradation/érosion du polymère. Au vu de l’absence de réaction inflammatoire, les microparticules développées sont correctement tolérées par les chondrocytes, synoviocytes, PBMC et neutrophiles, principales cellules impliquées dans les mécanismes inflammatoires de l’arthrose et de l’arthrite rhumatoïde. L’évaluation de l’efficacité anti-inflammatoire des microparticules vides et chargées en clonidine ou en bétaméthasone via l’étude de l’expression et de la sécrétion de différents médiateurs de l’inflammation a permis d’aboutir à plusieurs conclusions :(i) les microparticules vides sont associées à un effet anti-inflammatoire, (ii) les microparticules chargées en clonidine n’ont pas montré d’activité anti-inflammatoire propre pouvant être attribuée à la clonidine, et (iii) les microparticules de bétaméthasone ont confirmé l’effet anti-inflammatoire de la bétaméthasone. Enfin, l’étude de la toxicité des principes actifs et microparticules vides ou chargées a montré une toxicité significative de la clonidine sur les synoviocytes. Néanmoins, l’encapsulation des principes actifs dans les microparticules de PLGA a permis d’éliminer cette toxicité, protégeant donc efficacement les cellules articulaires.

Les microparticules développées permettent alors d’envisager l’encapsulation d’autres molécules anti-inflammatoires ou une combinaison de molécules ayant des effets complémentaires (anti-inflammatoire et antidouleur). L’utilisation de la clonidine dans ces indications devra être réévaluée en étudiant de façon approfondie son efficacité dans la douleur. / Both osteoarthritis and rheumatoid arthritis are articular diseases characterized by the degeneration of the joint cartilage, resulting from the production of various inflammatory mediators. The current treatment of these diseases is restricted to alleviate the painful and inflammatory episodes of the patients and to improve its quality of life. In osteoarthritic patients, few treatments allow to significantly stop the evolution of the degradation of the cartilage and, consequently, the disease. In rheumatoid arthritis, the evolution can be slowed down following the administration of some drugs. Nevertheless, these treatments are often associated to a short-term efficacy. The objective of this work is to develop new therapeutic options that allow to reduce the frequency of administration and the side effects of the current treatments. The intraarticular delivery combined to controlled-release presents the advantage to expose the sites directly involved in the evolution of the disease to one or more molecules effective to relieve the pain, inflammation and to help the regeneration of the cartilage.

Clonidine or betamethasone-loaded PLGA microparticles were optimized to reach suitable encapsulation efficiencies (clonidine HCl: EE ≈ 20%; betamethasone dipropionate: EE ≈ 70%), an appropriate size for an intraarticular delivery (12 – 38 µm) and a controlled-release of the molecule over 5 to 8 weeks. The release of clonidine implies mechanisms of diffusion and degradation/erosion of the polymer. Given the absence of an inflammatory reaction, the developed microparticles were properly tolerated by the chondrocytes, synoviocytes, PMBC and neutrophils, which are the main cells involved in the inflammatory reaction of osteoarthritis and rheumatoid arthritis. The assessment of the anti-inflammatory efficacy of the drug-free and drug-loaded microparticles through the evaluation of the expression and the secretion of various inflammatory mediators allowed to draw several conclusions: (i) drug-free microparticles were associated to an anti-inflammatory effect, (ii) clonidine-loaded microparticles did not show any anti-inflammatory activity that could be attributed to clonidine, and (iii) betamethasone- loaded microparticles confirmed the anti-inflammatory effect of betamethasone. Finally, the evaluation of the toxicity of the drugs and microparticles showed a significant toxicity of clonidine against synoviocytes. Nevertheless, the encapsulation of the drugs in PLGA microparticles induced the suppression of this toxicity, protecting in this way the articular cells.

Entrapping other anti-inflammatory molecules or a combination of molecules with complementary effects (anti-inflammatory and anti-nociceptive drugs) in the PLGA microparticles developed has to be considered. Moreover, the use of clonidine in these indications has to be reassessed by a thorough study of its anti-nociceptive potential.

Doctorat en Sciences biomédicales et pharmaceutiques
info:eu-repo/semantics/nonPublished

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Britschka, Zelia Maria Nogueira. ""Efeito antiinflamatório da lama negra de Peruíbe em diferentes modelos experimentais de artrite"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5145/tde-17042006-111503/.

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Investigar a eficácia da lama negra brasileira como tratamento para inflamação em modelos experimentais de artrite. O efeito antiinflamatório de aplicações de lama foi comparado ao tratamento com água aquecida e ausência de tratamento em modelos experimentais de artrite e osteoartrite induzidas em coelhos e em ratos, visando parâmetros inflamatórios e cartilagem. O tratamento com lama melhorou a infiltração de leucócitos e exerceu um efeito protetor parcial na sinóvia e cartilagem. Nossos resultados sugerem que a lama brasileira apresenta efeito antiinflamatório e pode ser útil como um método complementar ao tratamento de pacientes com doenças articulares crônicas
Investigate the effectiveness of a Brazilian black mud as treatment for inflammation in experimental models of arthritis. Effects of mud applications was compared with warm water and no treatment in experimental models of arthritis and osteoarthritis induced in rabbits and in rats, regarding inflammatory parameters and cartilage. Treatment with mud impaired leukocyte infiltration which was followed by a partial protective effect on synovium and cartilage. Our results show that Brazilian mud presents an anti-inflammatory effect and can be useful as a complementary approach to treat patients with chronicle articular diseases

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Yéléhé-Okouma, Mélissa. "Évaluation de l’activité biologique de la galectine 3 et d’une de ses formes tronquées dans la physiopathologie de l’arthrose." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0184.

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L’arthrose (OA) est un rhumatisme chronique dont la prise en charge médicamenteuse repose principalement sur les antalgiques et anti-inflammatoires, ce qui justifie la nécessité de rechercher d’autres cibles thérapeutiques. L’une de ces cibles potentielles est la galectine 3, une lectine sécrétée dans l’articulation au cours de la pathogenèse de cette maladie. Cette lectine interagit avec ses ligands à la surface des cellules articulaires pour engendrer des réactions inflammatoires et des phénomènes de catabolisme matriciel au niveau des tissus ostéo-articulaires, ce qui en fait une cible intéressante dans le traitement de l’OA. Le 1e objectif de ce projet de recherche est de mieux caractériser les effets biologiques de la galectine 3 sur le métabolisme chondrocytaire. Le 2e objectif est de concevoir des formes tronquées de galectine 3 et le 3e objectif est de démontrer leur potentiel d’inhibiteur de la forme entière de galectine 3 dans l’articulation. Ces travaux montrent que la galectine 3 est un facteur pro-inflammatoire, pro-catabolique mais aussi anti-anabolique dans le chondrocyte. Plusieurs formes tronquées recombinantes de galectine 3 ont été produites. Des tests préliminaires d’activité biologique in vitro démontrent que dans certaines conditions, l’une d’elles inhibe partiellement les effets biologiques de la galectine 3 sur des chondrocytes humains. Ces travaux de recherche constituent la preuve de concept d’un projet global s’inscrivant dans une perspective de thérapie génique pour l’OA
Osteoarthritis (OA) is a chronic rheumatism which drug management is based on antalgic and anti-inflammatory drugs, which requires the need to search for other therapeutic targets. One of these potential targets may be galectin 3, a lectin secreted in the joint during the pathogenesis of the disease. This lectin binds its ligands on the surface of the joint cells and thus, leads to inflammatory reactions and matrix catabolism phenomena, making it an attractive target in the treatment of OA. The 1st aim of our research project was to characterize the biological activity of galectin 3 on chondrocyte metabolism. The 2nd aim was to design and produce several truncated forms of galectin 3. The 3rd aim was to evaluate the presumed galectin 3-inhibiting activity of the truncated forms. This objective is part from the perspective of gene therapy for OA. Our work shows that galectin 3 is a proinflammatory, procatabolic but also an antianabolic factor in chondrocytes. Several recombinant truncated forms of galectin 3 were designed and produced. Preliminary tests of biological activity in vitro show that the chosen truncated lectin partially inhibits the biological activity of galectin-3 on human chondrocytes under a few conditions. This work is the proof of concept of a broader project of which perspective is gene therapy in OA

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Johnson, Levona. "The effect of hydrotherapy on the pain levels, stress levels, quality of life and functional disability in patients with rheumatic disease." University of Western Cape, 2011. http://hdl.handle.net/11394/3936.

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Magister Scientiae (Physiotherapy) - MSc(Physio)
Rheumatic disease is estimated to be one of the most disabling diseases in South Africa and the world. The most common rheumatic diseases are osteoarthritis, fibromyalgia, rheumatoid arthritis, gout and systemic lupus erythematosus. The symptoms of the disease include pain, stiffness, swelling, decreased function. The patient’s functional abilities are severely affected by the pain which in turn, leads to poor quality of life and adverse stress. As a result patients who suffer with one or with a combination of rheumatic disease will experience pain, stress, decreased functional abilities and poor quality of life. The physical properties of water and the therapeutic effects of hydrotherapy, make hydrotherapy an effective form of exercise available to physiotherapists in the treatment of rheumatic disease. The aim of the current study was to determine the effects of a hydrotherapy intervention on the pain, stress, quality of life and functional abilities in patients with rheumatic disease. A quantitative and qualitative research design was employed to meet the objectives. The quantitative aspect involved an A-B-A design and the qualitative part of the study compromised indepth interviews which took place after the intervention. The instruments used were the WHOQOL-BREF instrument, the Visual Analogue Scale (VAS), the Weekly Stress Inventory-Short Form (WSI-SF) and the Health Assessment Questionnaire. (HAQ). The sample consisted of 19 patients who were diagnosed with one or a combination of rheumatic disease. The study was conducted at the hydrotherapy pool at Groote Schuur Hospital in Cape Town. Within the study sample, the majority of the participants were female (84%) with osteoarthritis being common among the participants (53%). The mean age was 60 years. The intervention had a significant impact on pain reduction (p = 0.0001), quality of life (p<0.05). However, the impact of hydrotherapy on stress and the social relationship domain in quality of life was inconclusive. It is thus evident from this study that hydrotherapy as a treatment modality for physiotherapists can be used to impact on the pain, quality of life and functional abilities in patients with rheumatic disease. iv Keywords

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23

Hallbeck, Anna-Lotta. "Studies of transforming growth factor alpha in normal and abnormal growth." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1025s.pdf.

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Wu, Polin, and 吳柏林. "Matrix metalloproteinases in gouty arthritis, osteoarthritis, and rheumatoid arthritis." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/87075592874669539409.

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碩士
慈濟大學
醫學研究所
94
Arthritis, including gouty arthritis, osteoarthritis, and rheumatoid arthritis, is the leading cause of joint disability. The expense in treatment of arthritis is one of the major causes of orthopedic cost in health insurance in Taiwan. The cost is about 20 billion NTD every year. Matrix metalloproteinases (MMPs), collectively called matrixins, are proteinases that participate in extracellular matrix (ECM) degradation. The activities of MMPs are precisely regulated at the level of transcription, activation of the precursor zymogens, interaction with specific ECM components, and inhibition by endogenous inhibitors under normal physiological conditions. Loss of normal regulation may result in diseases such as arthritis. The main interest in the MMPs relates to their role in certain disease states in which breakdown of the extracellular matrix is a key feature. The purpose of this study is to demonstrate the MMP activities in different arthritic patients through direct examination of mRNA of synovial fibroblasts and chondrocytes after arthroscopic synovectomy , and to find out the relationship between different MMPs and diseases. We used RT-PCR to analyze mRNA of MMP-1, 2, 3, 8, 9, 10, 13, 14 in arthroscopic synovectomy samples for 29 arthritic patients including 8 GA, 17 OA, and 4 RA. We have found that the expression of MMP-1 was significantly higher in patients with OA and RA than in patients with GA. MMP-2 has been shown to be expressed in all arthroscopic synovectomy samples. MMP-3 positive patients showed higher level of CRP. The expression of MMP-1 and MMP-9 was significantly higher in patients with RA than in patients with OA. Further investigations, including serum and joint fluid MMPs level analysis at OPD follow-up a period from arthroscopy, and differentiating synovial MMPs level from that of chondrocytes, need to be performed to elucidate further the biological effects of MMPs in arthritis.

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25

Wover, Roberta Michelle Antoinette. "Rheumatoid arthritis and osteoarthritis synovial fibroblasts express Fc[alpha]R (CD89) in vitro and in vivo : implications for rheumatoid arthritis." 2006. http://hdl.handle.net/1993/20698.

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Sandin, Jenny, and Jonas Smedberg. "Arbetsterapeutiska interventioner för personer med begränsad handfunktion på grund av artros eller reumatoid artrit." Thesis, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-41920.

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The purpose of this study was to describe the therapeutic interventions used for people with limited function of the hand due to osteoarthrtis or rheumatoid arthritis. The study was accomplished through a literature studie. Data were collected through a search of databases considering the criteras for inclusion or exclusion that were established by the authors before the search. Twelve articles were included in the study and analysed through a qualitative content analysis. Fivedifferent categories of occupational interventions were revealed through the analysis. The categories are orthotics, heat and cold treatment, information and education, strength and range of motion exercises and training in activity of daily life. The result of the analysis continued with an interpretation of OTIPM to furher iluminate the occupational focus of activity. A minority of the occupational interventions used as treatment of clients with a limited function of the hand due to osteoarthrits or rheumatoid arthritis correspond to the focus of activity described in OTIPM.
Validerat; 20110607 (anonymous)

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WEI, YIN-HSUAN, and 魏吟璇. "The risk of developing depressive disorder following osteoarthritis and rheumatoid arthritis: a comparative study." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9cahbf.

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碩士
長榮大學
醫務管理學系碩士班
106
Objective：Rheumatoid arthritis (RA) and Osteoarthritis (OA) are the most common chronic disability diseases, which frequently occur in elder people. The course of these two diseases is long, and patients often have continuous recurrence. Many studies showed that the risk of the depressive disorder in patients with OA or RA were higher than general population. However, few study examine the difference of depression risk between patients with OA and RA in Taiwan. This study aim at comparing the risk of depression onset between RA and OA patients. Methods：This is a nationwide retrospective cohort study using data (2000 to 2013) from a 100 million of randomly sampled NHI beneficiaries’ enrollment. Newly diagnosed RA patients were identified by ICD-9-CM, and OA patients were selected with propensity score matching. All the matched cohort participants were followed up to December 31, 2013 or the date of their death to check the occurrence of their first onset of depression, and those without onset of depression were censored on. The Cox proportional-hazard regression was used to estimate the risk of depression onset. Results：We identified a total of 854 subjects with a newly diagnosed RA and a total of 84,280 subjects with OA from January 1, 2000 to December 31, 2013. Using the propensity score matching, we selected 3,320 participants comprising 830 RA cases and 2,490 OA cases from above patients. The results showed that the majority of patients in both cohorts were women and the interquartile range of onset age was 50-69 years. Most of patients with RA sought medical advice in medical centers (44.73%), but most of those with OA in clinic (35.25%). The onset of depressive disorder in the RA cohort (25.60 months) is earlier than in the OA cohort (27.96 months). The RA cohort have the higher risk of depression onset than the OA cohort. The hazard ratio (HR) was 3.33-fold in the RA cohort than in the control cohort (95% confidence interval = 2.21–5.01). Conclusion： Patients with RA have a significantly higher risk of depression than the OA patients. Therefore, the assessment of the mental health status for RA patients should be taken into consideration for appropriate care. Key words：Rheumatoid Arthritis, Osteoarthritis, Depression, Cohort Study, Propensity Score

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Yadollahi, Benjamin. "Exprese interleukinu 20 a jeho význam u revmatoidní artritidy." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-323478.

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Rheumatoid arthritis (RA) is a chronic autoimmune disease that is associated with formation of autoantibodies, activation of inflammatory cascade and up-regulation of several cytokines. These processes lead to persistent synovial inflammation, joint damage and systemic manifestations. The aim of this diploma thesis is to characterize the role of a novel cytokine interleukin-20 (IL-20) in the pathogenesis of RA and to investigate its involvement in different stages of the disease as a potential surrogate biomarker. In this work, several methods including Enzyme-Linked Immunosorbent Assay (ELISA), Immunohistochemistry and Real-Time quantitative Polymerase Chain Reaction (RT-qPCR) have been employed. We demonstrated increased expression of IL-20 in the synovial tissue of RA compared with control osteoarthritis (OA) patients. Along with the up-regulation at sites of inflammation, concentrations of IL-20 were higher in the synovial fluid compared with circulating levels of IL-20. Furthermore, serum and synovial fluid IL-20 levels significantly correlated with RA disease activity. Synthesis of IL-20 was significantly increased in peripheral blood mononuclear cells (PBMCs) and synovial fibroblasts upon stimulation with some TLR ligands and pro-inflammatory cytokines. Although not regulating PBMCs functions in...

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Chou, Yi-Jiun, and 周怡君. "The Influence of Medical Resource Utilization and Outcomes for Total Hip Replacement in Patients with Primary Osteoarthritis, Rheumatoid Arthritis or Avascular Necrosis of Femoral Head." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/26565884286428358063.

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碩士
高雄醫學大學
醫務管理暨醫療資訊學系碩士在職專班
104
Purpose Total hip replacement (THR) is a useful treatment for end-stage hip joint disease. In Taiwan, osteoarthritis (OA), rheumatoid arthrirtis (RA), and avascular necrosis of femoral head (AVN) are three main causes for THR, especially the prevalence of AVN is higher than other country. The pourse of this study is to compare the trends, medical resourse utilization, and outcomes of THR among these three main diseases. Methods This is a retrospective longitudinal study. We used the National Health Insurance Research Database and collected the sample from 1996 to 2012 with the main diagnosis of OA, RA or AVN, and the revision cases were excluded. We compared the trends of prevalence, length of stay, and first operational hospitalized fees among OA, RA and AVN. Multiple linear regression was used to analyse the factors that affected the length of stay and hospitalized fees. We conducted a logistic regression method to analyse the factors of re-admission among these three diseases and the Cox survival analysis to analyse the risk factors of prosthetic infection, joint dislocation, peri-prosthetic fracture, or revision of THR among OA, RA and AVN. Results The prevalence of OA and AVN rise year by year gradually. The trends of length of stay, hospital fees, operation fees, anesthesia fees and special material fees are trending down in OA, RA and AVN. In rates of 30 days and 90 days re-admission, RA(6.3%、22.5%) and AVN(6.6%、22.7%) are higher the OA(3.9%、12.8%). In total hospital fees and length of stay, RA and AVN reveal significant higher fees and longer stay than OA(p<.001). In 30 days re-admission rate, AVN is higher than OA(OR=1.44，p<.001). In 90 days re-admission rate, ANV and RA are higher than OA (OR=1.57、1.44，p<.001). By Cox regression method, there is no significant difference in prosthetic infection amoung OA, RA, and ANV. In joint dislocation rate, ANV is higher than OA (HR=1.11，p=.024). In peri-prosthetic fractures, there is no significant difference. But in prosthesis revision, RA is significant lower than OA (HR=0.59，p=.003). Suggestions As THR is getting popular, and the prevalence of OA and AVN has risen gradually. The length of stay and total medial costs trends downward. This indicates even the numbers of THR increase, but the medical resource utilization maintains stable effectively by health insurance policy and regulation. In RA patients, the decreasing trend of receiving THR may be due to control of disease progress by improvement of medicine. The effects of RA disease control should be considered in the future. In re-admission, the risks of RA and AVN are higher than OA. Further evaluation of factors of AVN is necessary for reducing re-admission and saving the extra medical resource utilization.

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Johannsen, Inga. "Die entzündungsmodulierenden Eigenschaften von Adiponektin und Leptin und deren Wirkung auf chondrogene Progenitorzellen." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-8727-D.

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Abreu, Beatriz Malaguerra. "Relatórios de Estágio e Monografia intitulada “Cannabis sativa L.: Uma alternativa terapêutica para doenças reumáticas?”." Master's thesis, 2019. http://hdl.handle.net/10316/88300.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia
A Cannabis sativa L. é uma planta de crescimento rápido originária da Ásia que facilmente se espalhou pelo resto do mundo. Esta planta pode ser utilizada como fonte de fibras, para produção de plásticos e têxteis, como fonte de óleo de semente, como droga de abuso, para fins recreativos, ou como fármaco, para fins medicinais. Tem a capacidade de produzir mais de 400 produtos químicos, entre eles mais de 60 fitocanabinóides diferentes. Os fitocanabinóides interagem com o sistema endocanabinóide humano, produzindo efeitos fisiológicos como a analgesia, relaxamento muscular, imunossupressão, estimulação do apetite, etc. Entre eles, os mais estudados são o Δ9-tetrahidrocanabinol (Δ9-THC) (altamente psicotrópico), o canabidiol (CBD) e o ácido canabidiólico (CBN). Assim, são uma boa proposta como alternativa ao tratamento com medicamentos convencionais de doenças reumáticas como a Artrite Reumatóide (AR) e a Osteoartrose (OA), visto que esses medicamentos apresentam efeitos adversos significativos. Em termos legais, em Portugal ainda não é permitida a utilização de Cannabis sativa L. para fins medicinais no tratamento de AR ou OA. De acordo com os estudos e ensaios clínicos realizados, quer seja em humanos ou em animais modelos de doença, verificou-se a eficácia e segurança dos fitocanabinóides, principalmente do CBD. No entanto, ainda existem diversas lacunas por preencher, o que evidencia a necessidade de investigação e realização de mais ensaios clínicos.
Cannabis sativa L. is a fast-growing plant originating in Asia that has easily spread to the rest of the world. This plant can be used as a source of fiber, to produce plastics and textiles, as a source of seed oil, as a drug of abuse, for recreational purposes, or as a drug, for medicinal purposes. It has the capacity to produce over 400 chemicals, including over 60 different phytocannabinoids. Phytocannabinoids interact with the human endocannabinoid system, producing physiological effects such as analgesia, muscle relaxation, immunosuppression, appetite stimulation, etc. Among them, the most studied are Δ9-tetrahydrocannabinol (Δ9-THC) (highly psychotropic), cannabidiol (CBD) and cannabinol (CBN). Thus, they are a good suggestion as an alternative to the treatment with conventional drugs of rheumatic diseases such as Rheumatoid Arthritis and Osteoarthritis, since these last medicines have significant adverse effects. In legal terms, the use of Cannabis sativa L. for medicinal purposes in the treatment of Rheumatoid Arthritis or Osteoarthritis is not yet allowed in Portugal. According to studies and clinical trials conducted, either in humans or in animal models of disease, the efficacy and safety of phytocannabinoids has been verified, specially of CDB. However, several gaps remain to be filled, which highlights the need for further research and development of clinical trials.

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Delaurier, Ashley. "Wait Times to Rheumatology and Rehabilitation Services for Persons with Arthritis in Quebec." Thèse, 2011. http://hdl.handle.net/1866/7028.

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L’arthrite est l’une des causes principales de douleur et d’incapacité auprès de la population canadienne. Les gens atteints d’arthrite rhumatoïde (AR) devraient être évalués par un rhumatologue moins de trois mois suivant l’apparition des premiers symptômes et ce afin de débuter un traitement médical approprié qui leur sera bénéfique. La physiothérapie et l’ergothérapie s’avèrent bénéfiques pour les patients atteints d’ostéoarthrite (OA) et d’AR, et aident à réduire l’incapacité. Notre étude a pour but d’évaluer les délais d’attente afin d’obtenir un rendez-vous pour une consultation en rhumatologie et en réadaptation dans le système de santé public québécois, et d’explorer les facteurs associés. Notre étude est de type observationnel et transversal et s’intéresse à la province de Québec. Un comité d’experts a élaboré trois scénarios pour les consultations en rhumatologie : AR présumée, AR possible, et OA présumée ; ainsi que deux scénarios pour les consultations en réadaptation : AR diagnostiquée, OA diagnostiquée. Les délais d’attente ont été mesurés entre le moment de la requête initiale et la date de rendez-vous fixée. L’analyse statistique consiste en une analyse descriptive de même qu’une analyse déductive, à l’aide de régression logistique et de comparaison bivariée. Parmi les 71 bureaux de rhumatologie contactés, et pour tous les scénarios combinés, 34% ont donné un rendez-vous en moins de trois mois, 32% avaient une attente de plus de trois mois et 34% ont refusé de fixer un rendez-vous. La probabilité d’obtenir une évaluation en rhumatologie en moins de trois mois est 13 fois plus grande pour les cas d’AR présumée par rapport aux cas d’OA présumée (OR=13; 95% Cl [1.70;99.38]). Cependant, 59% des cas d’AR présumés n’ont pas obtenu rendez-vous en moins de trois mois. Cent centres offrant des services publics en réadaptation ont été contactés. Pour tous les scénarios combinés, 13% des centres ont donné un rendez-vous en moins de 6 mois, 13% entre 6 et 12 mois, 24% avaient une attente de plus de 12 mois et 22% ont refusé de fixer un rendez-vous. Les autres 28% restant requéraient les détails d’une évaluation relative à l’état fonctionnel du patient avant de donner un rendez-vous. Par rapport aux services de réadaptation, il n’y avait aucune différence entre les délais d’attente pour les cas d’AR ou d’OA. L’AR est priorisée par rapport à l’OA lorsque vient le temps d’obtenir un rendez-vous chez un rhumatologue. Cependant, la majorité des gens atteints d’AR ne reçoivent pas les services de rhumatologie ou de réadaptation, soit physiothérapie ou ergothérapie, dans les délais prescrits. De meilleures méthodes de triage et davantage de ressources sont nécessaires.
Arthritis is a leading cause of pain and disability in Canada. Persons with rheumatoid arthritis (RA) should be seen by a rheumatologist within three months of symptom onset to begin appropriate medical treatment and improve health outcomes. Early physical therapy (PT) and occupational therapy (OT) are beneficial for both osteoarthritis (OA) and RA and may prevent disability. The objectives of the study are to describe wait times from referral by primary care provider to rheumatology and rehabilitation consultation in the public system of Quebec and to explore associated factors. We conducted a cross-sectional study in the province of Quebec, Canada whereby we requested appointments from all rheumatology practices and public rehabilitation departments using case scenarios that were created by a group of experts. Three scenarios were developed for the rheumatology referrals: Presumed RA; Possible RA; and Presumed OA and two scenarios for the rehabilitation referrals: diagnosed RA and diagnosed OA. Wait times were evaluated as the time between the initial request and the appointment date provided. The statistical analysis consisted primarily of descriptive statistics as well as inferential statistics (bivariate comparisons and logistic regression). Seventy-one rheumatology practices were contacted. For all scenarios combined, 34% were given an appointment with a rheumatologist within three months of referral, 32% waited longer than three months and 34% were refused services. The odds of getting an appointment with a rheumatologist within three months was 13 times greater for the Presumed RA scenario versus the Presumed OA scenario (OR=13; 95% Cl[1.70;99.38]). However, 59% of the Presumed RA cases did not receive an appointment within three months. One hundred rehabilitation departments were also contacted. For both scenarios combined, 13% were given an appointment within 6 months, 13% within 6 to 12 months, 24% waited longer than 12 months and 22% were refused services. The remaining 28% were told that they would require an evaluation appointment based on functional assessment prior to being given an appointment. There was no difference with regards to diagnosis, RA versus OA, for the rehabilitation consultation. RA is prioritized over OA when obtaining an appointment to a rheumatologist in Quebec. However, the majority of persons with RA are still not receiving rheumatology or publicly accessible PT or OT intervention in a timely manner. Better methods for triage and increased resource allocation are needed.

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Wagner, France. "Expression du récepteur B1 des kinines dans les membranes synoviales ostéoarthritiques humaines." Thèse, 2008. http://hdl.handle.net/1866/8156.

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Šromová, Lucie. "Molekuly "DASH systému" v lokálních a systémových patogenetických procesech revmatoidní artritidy." Doctoral thesis, 2015. http://www.nusl.cz/ntk/nusl-351037.

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The biological half-life of several pro-inflammatory mediators involved in the pathogenesis of rheumatoid arthritis (RA) is controlled by molecules exhibiting dipeptidyl peptidase-IV (DPP-IV)-like enzymatic activity (Dipeptidyl peptidase-IV activity and/or structure homologues- DASH). The aim of this thesis was to identify the molecular source of the DPP-IV-like enzymatic activity in the peripheral blood and synovial fluid in patients with rheumatoid arthritis as compared to control patients with osteoarthritis (OA), and to evaluate the association of DPP-IV with the disease activity. We found that the main source of the DPP-IV-like enzyme activity in the plasma and in the synovial fluid in patients with RA is the canonical DPP-IV. DPP-IV-like enzymatic activity and canonical DPP-IV were also detected on the cell surface of blood and synovial fluid mononuclear cells. Significantly lower DPP-IV-like enzymatic activity and DPP-IV expression in the synovial fluid mononuclear cells was found in RA as opposed to OA patients. In the synovial fluid of RA patients there was also a negative correlation between the concentration of the pro-inflammatory DPP-IV substrate SDF (stromal cell-derived factor-1 and the proportion of the DPP-IV+ T cells. The blood plasma DPP-IV-like enzymatic activity and...

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Fonseca, Ana Cláudia Oliveira. "Aspetos bioquímicos das doenças músculo-esqueléticas." Master's thesis, 2019. http://hdl.handle.net/10284/8735.

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Nesta dissertação pretende-se perceber e identificar as principais alterações bioquímicas que ocorrem nas doenças músculo-esqueléticas, nomeadamente no raquitismo, osteoporose, osteomalacia, doença de Paget, gota, artrite reumatoide, osteoartrite, algumas distrofias musculares e miopatias metabólicas. Nesse sentido, foi alvo de análise o reconhecimento dos possíveis marcadores bioquímicos de cada doença, sendo realçada a forma como os mesmos podem ser utilizados no diagnóstico. Adicionalmente, foram identificados os tratamentos e fármacos empregues em cada patologia, bem como apresentadas as moléculas que se encontram disponíveis em Portugal. Foi realizada uma extensa revisão bibliográfica com o intuito de análise do estado atual em termos de conhecimento nesta área, reconhecendo as lacunas existentes e percebendo de que forma a ciência está a evoluir no desenvolvimento do tema. Assim, identificaram-se as alterações e os marcadores bioquímicos mais utilizados para o diagnóstico das doenças músculo-esqueléticas. A enzima fosfatase ácida resistente ao tartarato, os produtos resultantes do catabolismo do colagénio, a enzima fosfatase alcalina, a osteocalcina, pró-péptidos do colagénio tipo I, cálcio, fósforo, formas ativas de vitamina D, ácido úrico e marcadores pró-inflamatórios, integram alguns dos mais importantes. Concluiu-se que os biomarcadores, pelas potencialidades identificadas, devem ser utilizados na prática clínica e constituírem parte integrante do diagnóstico das várias patologias. De entre as potencialidades são realçadas a capacidade para identificação de riscos e propensão para a ocorrência de uma doença, a capacidade para estratificar doentes e identificar a gravidade e/ou progressão de uma determinada patologia, previsão do prognóstico e aptidão para a monitorização de um determinado tratamento.
This dissertation aims to understand and identify the main biochemical changes that occur in musculoskeletal diseases, namely rickets, osteoporosis, osteomalacia, Paget's disease, gout, rheumatoid arthritis, osteoarthritis, some muscular dystrophies and metabolic myopathies. In this sense, the target of analysis was the recognition of possible biochemical markers of each disease, highlighting how they can be used in the diagnosis. Additionally, the treatments and drugs used in each pathology were identified, as well as the molecules that are available in Portugal. An extensive literature review was conducted to analyze the current state of knowledge in this area, recognizing the existing gaps and understanding how science is evolving in the development of the theme. Thus, it was identified the most used biochemical markers and alterations for the diagnosis of musculoskeletal diseases. Tartrate-resistant acid phosphatase enzyme, collagen catabolism products, alkaline phosphatase enzyme, osteocalcin, type I collagen propeptides, calcium, phosphorus, active forms of vitamin D, uric acid and pro-inflammatory markers, integrate some of the most important. It was concluded that the biomarkers, due to the identified potentialities, should be used in clinical practice and be an integral part of the diagnosis of the various pathologies. Among the potentialities are highlighted the ability to identify risks and propensity for the occurrence of a disease, the ability to stratify patients and to identify the severity and/or progression of a given pathology, prediction of prognosis and ability to monitor a treatment.

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Dissertations / Theses on the topic 'Rheumatoid arthritis Rheumatoid arthritis Osteoarthritis Osteoarthritis Hydrocortisone'

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