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Wilson, Susan Jane. "Mucosal inflammation in allergic rhinitis." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295233.
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Terreehorst, Ingrid. "Mite avoidance in allergic rhinitis: a cover story? encasings, symptoms and quality of life in allergic rhinitis = Sanatie bij allergische rhinitis: inpakken is wegwezen? : mijtwerende hoezen, klachten en kwaliteit van leven bij allergische rhinitis /." [S.l.] : Rotterdam : [De auteur] ; Erasmus University [Host], 2004. http://hdl.handle.net/1765/7274.
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Bhimrao, Sanjiv Kumar. "Airway structural changes in allergic rhinitis." Thesis, University of Southampton, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536296.
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Tabbah, Khaldoun. "Specific immunotherapy for perennial allergic rhinitis." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299414.
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Salib, Rami Jean. "Mast cell chemoattractants in allergic rhinitis." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420254.
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Wang, Youna. "The epidemiology survey of uncontrolled allergic rhinitis and allergic rhinitis control test questionnaire-driven stepwise pharmacotherapy in Wuhan." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT054/document.
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Introduction: Le traitement de la rhinite allergique (RA) est maintenant bien établi et la plupart des patients atteints par cette maladie y répondent. Néanmoins, il existe un pourcentage de patients qui ne sont pas contrôlés, malgré un traitement maximal, amenant au concept de SCUAD (Severe Chronic Upper Airway Disease), acronyme anglais pour "atteinte sévère et chronique des voies aériennes supérieures". En Chine, les données concernant la RA non contrôlée et le SCUAD sont insuffisantes. Le test de contrôle de la rhinite allergique (Allergic Rhinitis Control Test, ARCT) est un outil validé pour évaluer le contrôle de la RA et identifier la RA sévère. Néanmoins, l'ARIA (Allergic Rhinitis and its Impact on Asthma, acronyme anglais pour Rhinite Allergique et son Impact sur l'Asthme) n'offre pas de définition claire du contrôle de la RA et, du fait de l'absence de critères uniformes, le choix de la pharmacothérapie varie dans différentes régions et populations. Objectif: La première étude a eu pour objectif d'évaluer la prévalence et les caractéristiques des patients avec RA non contrôlée et SCUAD à Wuhan. A partir de cette étude préliminaire, une autre étude a été mise en oeuvre, pour évaluer le rôle de l'ARCT en tant qu'outil pour guider une pharmacothérapie par paliers, dans le but d'atteindre le contrôle de la RA. Méthode : Dans la première étude, tous les patients consultant pour une RA ont été évalues en prospectif par EVA et ARCT, et mis sous traitement selon le guide ARIA. Au bout de 15 jours (J15), une interview téléphonique a permis de ré-évaluer la RA au moyen d'une échelle numérique et de l'ARCT. La RA non contrôlée était définie par un score ARCT<20. Les patients souffrant de SCUAD étaient définis par un score ≥5 à J15. Dans la 2ème étude prospective, un traitement pharmacologique standard a été proposé aux patients souffrant de RA. Les paliers allaient du palier 1 (antihistaminique H1 à la demande) jusqu'au palier 5 (corticoïde oral). La RA était traitée et évaluée tous les 15 jours par ARCT. Si le score ARCT était ≥20, maintenu pendant 15 jours, le patient terminait l'étude. Si l'ARCT était <20, le patient recevait le prochain palier de traitement, selon une démarché prédéfinie, progressive, jusqu'au palier 5. Résultats: Au total, 252 patients ont été inclus dans la 1ère étude. La RA modérée/sévère était présente en 82,9% des patients, avec un impact sur le sommeil, travail, activités sociales et physique. Les patients avec RA non contrôlée à J15 étaient ceux avec un poids plus important (P=0,042), antécédents d'infections ORL ou de prise d'antibiotiques pour infections respiratoires dans les derniers 12 mois (62,3 vs. 45,6%, P=0,018), de tabagisme (P=0,024) et de dysosmie (P=0,005). Les patients avec SCUAD avaient plus fréquemment des antécédents d'infections ORL ou de prise d'antibiotiques pour infections respiratoires (P=0,014) et de dysosmie (P=0,003) et moins fréquemment de dermatite atopique (P=0,017). 255 patients ont été inclus dans la 2ème étude. Seulement 3,2% sont restés non contrôlés à la fin de l'étude. Les patients avec une RA modérée à sévère selon ARIA, RA persistante, impact modéré à sévère sur la qualité de vie, antécédents d'asthme, rhinorrhée et toux avaient toujours besoin d'un traitement associé, ainsi qu'un traitement prolongé pour atteindre le contrôle. Après ajustement sur chacune des variables, le seul facteur de risque restant significatif était la présence d'un asthme (il était moins probable que ces patients soient contrôlés par les premiers paliers de traitement). Conclusion: Les patients ayant une RA non-contrôlée ou atteints de SCUAD sont nombreux. L'EVA et l'ARCT sont des outils simples qui peuvent être utilisés dans l'évaluation globale de la sévérité et du contrôle de la RA. L'ARCT offre un critère objectif pour guider le traitement par paliersBackground : The treatment of Allergic rhinitis (AR) is now well established and most patients respond well to the treatment. However, there are still some patients with uncontrolled AR despite optimal maximum treatment, leading to the concept of severe chronic upper airway disease (SCUAD). In China, there are insufficient epidemiological data regarding uncontrolled AR and SCUAD. Allergic Rhinitis Control Test (ARCT) has been validated for assessing AR control and to identify severe AR. However, Allergic Rhinitis and its Impact on Asthma (ARIA) still has no clear definition of AR control, and due to the absence of uniformed criteria, pharmacotherapy adjustment regimens varies in different areas and populations. ObjectiveThe first study aimed to assess the prevalence and the characteristics of patients with uncontrolled AR and SCUAD in Wuhan. On the basis of the preliminary study, a further study is designed to assess ARCT as a questionnaire driven stepwise pharmacological treatment to achieve AR control. Methods : In the first epidemiology study, all patients consulting for AR were prospectively assessed using VAS and ARCT and put on standardized treatment based on ARIA guidelines. After 15 days, they were reevaluated by a telephone interview using a numerical scale and ARCT. A score of ARCT <0 defined uncontrolled AR and a score ≥5 at day-15 defined SCUAD patients.In the second study, a standard pharmacotherapy regimen from step1 (oral second generation H1 antihistamine as needed) to step 5 (oral corticosteroid) was applied prospectively in a Chinese AR population. The AR patients were initiated with ARIA appropriate step treatment and assessed with ARCT every 15 days. If ARCT score was equal or above 20 and maintained for 15 days, the patient would finish the study; if ARCT score was strictly less than 20, the patient would receive higher step treatment according to a predefined open design up to step 5. Results: A total of 252 patients were included in the first study. Moderate/severe AR was diagnosed in 82.9% of the patients and they had an impact on sleep, work life, social activities and physical activities. Patients with uncontrolled ARat day-15 more frequently presented a higher weight (P=0.042), past history of ENT infection or antibiotics intake for respiratory infection in the last 12 months (P=0.018), smoking (P=0.024) and smell disturbance (P=0.005). Patients with SCUAD more frequently presented a past history of ENT infection or antibiotics intake for respiratory infection (P=0.014) and smell disturbance (P=0.003), while less commonly had atopic dermatitis (P=0.017). 255 patients were enrolled in the second study. Only 3.2% patients remained uncontrolled at the endpoint of the study. Patients with ARIA moderate/severe or persistent symptoms, moderate/severe impaired quality of life, asthma history, rhinorrhea and cough symptoms always needed up to step 4 and prolonged treatments to achieve disease control. After adjustment on each of the variables, the only factor that remained significant was asthma (less likely to be in a group controlled by the first steps’ therapies) .Conclusion: Uncontrolled AR and SCUAD patients are numerous. VAS and ARCT are simple and quantitative methods and self-completion questionnaire that can be used for a global evaluation of the severity and control of AR. ARCT offers an objective criterion for the stepwise pharmacotherapy of AR. Risk factor analysis did not reveal strong clinical characteristics that would help the physician to control AR better
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Caimmi, Davide. "Contribution of real-life databases of adult patients suffering from allergic rhinitis Validation of the MASK‐rhinitis visual analogue scale on smartphone screens to assess allergic rhinitis control Discriminating severe seasonal allergic rhinitis. Results from a large nation-wide database." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS510.
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La prévalence de la rhinite allergique (RA) est en augmentation dans le monde entier. Malheureusement, cette maladie est souvent considérée comme triviale, et les patients ont une tendance à ne pas consulter un médecin, malgré le fait que la RA a un impact très important sur leur qualité de vie. Les recommandations ARIA conseillent d’évaluer la sévérité de la maladie avant traitement et le contrôle des symptômes au cours du suivi pour optimiser le traitement, améliorer la qualité de vie des patients, et diminuer le coût de la RA. En analysant des bases de données en vie réelle, nous avons détecté un score simple et pratique qui permet aux médecins d’évaluer la sévérité de la RA et nous avons validé un système pour vérifier le contrôle des symptômes par visual analogue scale (VAS) sur l’écran des smartphones. Cette validation se base sur les données recueillies par l’application pour smartphones « MASK-Air® » et a été réalisé selon les recommandations COSMIN, avec évaluation, de la cohérence interne, de la fiabilité, de la sensibilité, et de l’acceptabilité. Le score pour évaluer la sévérité se base sur les résultats de l’étude Pollin’Air, après comparaison de 5 méthodes de classification des patients (deux types d’analyses en cluster, un score à 17 questions, le score ARPhyS à 5 questions et le VAS). L’évaluation de la sévérité et du contrôle de la RA sont essentielles pour bien gérer les patients, leurs symptômes et leur qualité de vie. Grâce à l’analyse de bases de données en vie réelle, nous avons validé des outils faciles à utiliser et à comprendre, et rapides à compléter, et qui peuvent donc être vraiment utilisés dans la pratique cliniqueThe prevalence of allergic rhinitis (AR) is increasing worldwide. Unfortunately, this disease is often considered as trivial, and patients tend not to consult their physician, and even less a specialist, even though AR has a very significant impact on the quality of life of patients, which translates into a risk of absenteeism and impaired presenteeism. ARIA guidelines recommend evaluating the severity of the disease before treatment and the control of symptoms during follow-up to optimize treatment, improve patients’ quality of life, and reduce the direct and indirect cost of AR. By analyzing real-life databases, we detected a simple and practical score that allows physicians to assess AR severity and we validated a system to verify the control of symptoms by a visual analogue scale (VAS) on smartphone screens. This last validation was based on data collected by the “Allergy Diary / MASK-Air®” application for smartphones of the MASK study. It was carried out according to COSMIN criteria, with an evaluation, among other things, of internal consistency, reliability, sensitivity, and acceptability. The score to assess AR severity is based on the results of the Pollin'Air study, after comparison of 5 methods for patients’ classification (two types of cluster analyses, a 17-question score, the 5-question ARPhyS score and the VAS). Assessing both severity and control in AR is essential to properly manage patients, their symptoms and quality of life. Through the analysis of real-life databases, we validated tools that are easy to use and understand, and quick to complete, therefore meet the essential characteristics to be truly used in clinical practice
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Burte, Marthe-Emilie 1989. "Rhinitis: characterisation and association with air pollution." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/664241.
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La rinitis tiene un impacto importante en la salud pública, sin embargo en los adultos no existe una estandarización de la definición en los estudios epidemiológicos. Además, apenas se conocen los factores ambientales de la rinitis y, en particular, existen muy pocos estudios sobre los efectos de la contaminación atmosférica a largo plazo sobre la rinitis en adultos. Para llenar estos vacíos, utilizamos datos de dos estudios epidemiológicos europeos multicéntricos con datos extensos sobre la salud respiratoria y con datos de exposición individual a la contaminación atmosférica a largo plazo. Nuestros resultados mostraron que para caracterizar mejor la rinitis, es necesario considerar conjuntamente todas las características de los síntomas nasales, las comorbilidades y la sensibilización alérgica, y no restringir la enfermedad a una pregunta o a una prueba de sensibilización alérgica. No encontramos asociación entre la contaminación atmosférica a largo plazo y la incidencia de rinitis, pero demostramos que la exposición a la contaminación del aire a largo plazo aumenta la severidad de la rinitis, enfatizando que es necesario controlar la contaminación atmosférica.Whereas rhinitis has an important public health impact, in adults there is no standardized definition of rhinitis in epidemiological studies. Furthermore, environmental factors of rhinitis are barely known, and in particular, there are very few studies on the effects of long-term exposure to air pollution on rhinitis in adults. To fill these gaps, we used data from two European multicentre epidemiological studies with extensive data on respiratory health and individual estimated exposures to long-term air pollution. Our findings showed that to better characterize rhinitis, one need to consider together all the characteristics of the nasal symptoms, the comorbidities and the allergic sensitization, and not to restrict the disease to one question or one allergic sensitization test. We found no association between long-term air pollution and incidence of rhinitis, but we showed that long-term exposure to air pollution is associated to an increased severity of rhinitis, emphasising that air pollution needs to be controlled.
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Christodoulopoulos, Pota. "Monocyte chemotactic proteins in allergen-induced rhinitis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0022/MQ50737.pdf.
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Christodoulopoulos, Pota. "Monocyte chemotactic proteins in allergen-induced rhinitis." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21526.
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Allergen-induced rhinitis is associated with the recruitment and activation of inflammatory cells, particularly eosinophils and CD4 + T cells into the nasal mucosa. Monocyte chemotactic proteins (MCPs) have been shown to induce chemotactic activity in these particular cell types under in vitro assay conditions. To assess the contribution of MCPs in the recruitment of inflammatory cells in vivo, we investigated the allergen-induced late response in subjects with allergic rhinitis. Using immunocytochemistry and in situ hybridization, we demonstrated a constitutive expression of MCP-1, -3 and -4, of which MCP-3 and -4 were significantly increased in the nasal mucosa following allergen provocation. This upregulation of MCP-3 and 4 immunoreactivity in response to allergen, was reduced in patients pretreated with topical corticosteroids. Colocalization experiments revealed that the majority of MCP-positive cells were macrophages. The results of this study suggest that allergen-induced rhinitis is associated with an increased expression of MCP-3 and -4, which may be closely related to the influx of inflammatory cells and may thus contribute to the pathogenesis of allergic rhinitis.
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Watts, Annabelle. "Immune and microbiome regulation in allergic rhinitis." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/389662.
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Allergic rhinitis (AR) is a common chronic upper respiratory disease where exposure to allergens causes an IgE mediated inflammatory response. AR is estimated to affect between 10-40% of the population worldwide and is responsible for significant economic and medical burden. The primary symptoms of AR include rhinorrhoea, nasal congestion, itchy nose and eyes and sneezing. There is currently no cure for AR and the current treatment options are typically focused on achieving symptom relief. Whilst the symptoms of AR manifest predominately in the upper respiratory tract, the pathophysiology of the disease is complex, and involves interactions between the mucosal and systemic immune systems. As such, there is an increasing need to better understand the complex immunological mechanisms which underpin the disease. Doing so may lay the foundation for strategies to reduce AR symptoms through modifying the disease process itself or via the development of novel therapies.
In a series of six studies, this thesis investigated the pathophysiology and treatment of AR via immune and molecular phenotyping of the gut microbiome, peripheral blood, and nasal mucosa.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Griffith Health
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Hamilton, Timothy David Conrad. "Airborne pollution and progressive atrophic rhinitis in pigs." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295103.
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Feng, Zijie. "Machine learning methods for seasonal allergic rhinitis studies." Thesis, Linköpings universitet, Statistik och maskininlärning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173090.
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Seasonal allergic rhinitis (SAR) is a disease caused by allergens from both environmental and genetic factors. Some researchers have studied the SAR based on traditional genetic methodologies. As technology develops, a new technique called single-cell RNA sequencing (scRNA-seq) is developed, which can generate high-dimension data. We apply two machine learning (ML) algorithms, random forest (RF) and partial least squares discriminant analysis (PLS-DA), for cell source classification and gene selection based on the SAR scRNA-seq time-series data from three allergic patients and four healthy controls denoised by single-cell variational inference (scVI). We additionally propose a new fitting method consisting of bootstrap and cubic smoothing splines to fit the averaged gene expressions per cell from different populations. To sum up, we find that both RF and PLS-DA could provide high classification accuracy, and RF is more preferable, considering its stable performance and strong gene-selection ability. Based on our analysis, there are 10 genes having discriminatory power to classify cells of allergic patients and healthy controls at any timepoints. Although there is no literature founded to show the direct connections between such 10 genes and SAR, the potential associations are indirectly confirmed by some studies. It shows a possibility that we can alarm allergic patients before a disease outbreak based on their genetic information. Meanwhile, our experiment results indicate that ML algorithms may discover something between genes and SAR compared with traditional techniques, which needs to be analyzed in genetics in the future.
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Sommer, Nadine. "Untersuchungen zum allergenen Potential der luftgetragenen Algen Stichococcus bacillaris, Tetracystis aeria und Xanthonema montanum." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-132660.
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Die Allergische Rhinitis als Allergie vom Typ I (Soforttyp) ist nicht nur in Deutschland und Europa weit verbreitet, sondern eine weltweit auftretende Erkrankung. Als Verursacher werden neben bereits bekannten Aeroallergenen wie Hausstaubmilben, Gräser oder Pollen auch luftgetragene Algen diskutiert, die als möglichen Mechanismus über eine T-Zell-abhängige Stimulation Antigen-bindender B-Zellen zur IgE-Produktion führen. Diese Arbeit befasst sich mit der Untersuchung des allergenen Potentials der luftgetragenen Algenspezies S. bacillaris, T. aeria und X. montanum. Dafür wurden mittels direkter und indirekter Sandwich-ELISA-Verfahren Seren von Patienten mit der Diagnose Allergische Rhinitis oder Idiopathische Rhinitis auf enthaltene IgE-Antikörper getestet, die spezifisch an festphasengebundene Algenproteine binden. Des Weiteren wurden Kompetitionstestungen zur Untersuchung der Kreuzhemmbarkeit der drei Algen sowie SDS-Gelelektrophoresen und Western Blots zur Bestimmung der Molmasse der Algenproteine und zum Nachweis der Spezifität des algenbindenden IgEs durchgeführt. Die Ergebnisse belegen, dass die getesteten Algenproteine in der Lage sind, eine entsprechende Immunantwort mit IgE-Produktion auszulösen. Diese neue Gruppe von Allergenen konnte hinsichtlich der Entstehung einer Allergie vom Soforttyp und der damit verbundenen klinischen Bedeutung bewertet werden.
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Castaño, Roberto. "The association between rhinitis and asthma of occupational origin /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103382.
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The present thesis explores the relationship between occupational rhinitis and occupational asthma under the postulates of the "united airways disease" concept that refers to the multiple links observed between rhinitis and asthma. Accordingly, the main objective of this thesis is to demonstrate the concomitant expression of significant changes in nasal patency and bronchial calibre following exposure to occupational agents during specific inhalation challenges, complementing the assessment with the investigation of changes in markers of airways inflammation in nasal lavage. To achieve the objectives, we set up a protocol to diagnose occupational rhinitis and conducted a study from January 2005 to January 2007 at Hopital du Sacre-Coeur de Montreal in subjects undergoing investigation for occupational asthma. The reliability of the main research tools---acoustic rhinometry and nasal lavage---used to investigate occupational rhinitis was tested by analyzing the reproducibility of the methods. Both methods proved sufficiently reproducible to be included in our investigative protocol. The results presented in this thesis demonstrate a joint reaction of the nose and the lungs in a group of study subjects after performing specific inhalation challenge. This supports the concept of a "united airways disease" and its applicability to rhinitis and asthma of occupational origin. However, the results also show that although occupational rhinitis frequently coexists with occupational asthma it can also be present without occupational asthma. The assessment of upper airways inflammation in a subgroup of study subjects by the nasal lavage method allows us to observe significant changes in eosinophils counts after the challenge that correlates with the decrease in nasal patency observed in the same subjects.
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Harries, Helen Elizabeth. "Antibodies in the nasal mucosa : implications for allergic rhinitis." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582540.
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Allergic rhinitis is the outcome of an IgE-mediated allergic response in the nose. Previous studies of IgE produced by B-cells in the nasal mucosa of allergic rhinitis patients have shown an increased usage of the V H5 gene family, compared to the normal blood V H gene repertoire, which has been attributed to superantigen activity. Work reported in this thesis has been undertaken to investigate further how the antibody repertoire is shaped in allergic rhinitis. IgA-expressing B-cells in the nasal mucosa, from allergic and non-allergic donors, were also shown to have an increased usage of VH5 genes compared to the normal blood repertoire, suggesting the nasal environment favours VH5 expansion prior to allergy development. Somatic hypermutation patterns in VH5-Ca sequences were indicative of superantigen selection. FACS analysis of nasal turbinate cells with antibodies to S. aureus enterotoxins (SE) demonstrated TSST -1 + cells in allergic nasal tissue only. Incubation of nasal turbinate tissue with SEs appeared not to influence the VH-Cϵ repertoire in 24 hours, but SED + IL-4 may have inhibited VH-Cϵ transcription in allergic patients. Evidence of local antigen stimulation prior to SE incubation was evident in one of the patients; a large VH5 clonal family exhibiting extensive somatic hypermutation was present throughout the nasal turbinate. FACS sorting of Phl pl-binding plasma cells and single cell RT-PCR enabled cloning of a scFv fragment representing the V regions of a physiological, allergen-specific antibody expressed in allergic nasal mucosa. The scFv cloning protocol has also been applied to VH5 genes of interest, thus facilitating the study of their protein structure and function. This research increases the evidence for local, VH5-selecting, superantigen activity in the nasal mucosa and has developed a platform for further investigation of nasal antibody- superantigen / allergen interactions in allergic rhinitis.
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Bradding, Peter. "Cytokine expression in allergic mucosal inflammation." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295929.
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Сміянов, Владислав Анатолійович, Владислав Анатольевич Смиянов, Vladyslav Anatoliiovych Smiianov, and М. В. Кушніренко. "Сучасні методи лікування вазомоторного й алергійного риніту." Thesis, Вид-во СумДУ, 2006. http://essuir.sumdu.edu.ua/handle/123456789/7971.
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Жукова, А. М., Владислав Анатолійович Сміянов, Владислав Анатольевич Смиянов, and Vladyslav Anatoliiovych Smiianov. "Опыт применения радиохирургического аппарата "Сургитрон" при лечении вазомоторного ринита." Thesis, Видавництво СумДУ, 2008. http://essuir.sumdu.edu.ua/handle/123456789/6900.
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Jonkmanns, Claudia. "Untersuchungen zum Primingeffekt bei der allergischen Rhinitis durch wiederholte Allergenprovokation." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967732379.
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Fuertes, Elaine Isabelle. "Childhood allergic rhinitis : the role of the environment and genetics." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50842.
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Allergic rhinitis is a global health problem that causes major illness and disability. Inherited and environmental factors influence its development. This thesis examined the role of traffic-related air pollution, genetic variants and their potential interactions, on childhood allergic rhinitis. Global spatial associations with climatic factors known to influence aeroallergen distributions were also studied.
Data from two Canadian (CAPPS and SAGE) and four European birth cohorts (BAMSE, GINIplus, LISAplus and PIAMA) participating in the Traffic, Asthma and Genetics collaboration were pooled. No consistent associations between individual-level traffic-related air pollutants (NO2, PM2.5 mass, PM2.5 absorbance and ozone) estimated to the home address and childhood allergic rhinitis were observed in a longitudinal analysis (up to ten years) of two cohorts (GINIplus and LISAplus; N=6,604) and a pooled analysis of all six cohorts (N=15,299). These latter null associations were not modified by ten tested single nucleotide polymorphisms in the GSTP1, TNF, TLR2 and TLR4 genes. Although these results do not support an adverse role of traffic-related air pollution on childhood allergic rhinitis, much remains to be learned regarding for whom, when and how air pollution may impact disease.
In further analyses, genetic variants in the TNF and TLR4 genes and at the 17q21 gene locus were found to be associated with childhood allergic rhinitis in pooled analyses of the six cohorts. As genetic variability in these regions has also been linked to asthma, the observed associations support the hypothesis of shared genetic susceptibility between asthma and allergic rhinitis. These results may be important for public health given the large proportion of the population carrying the studied risk variants.
Lastly, using cross-sectional data from 6-7 and 13-14 year-olds participating in the International Study of Asthma and Allergies in Childhood, several ecological spatial associations between climatic factors (temperature, precipitation and vapour pressure) and intermittent and persistent rhinitis symptom prevalences were identified. Although not conclusive, these results represent a first step in investigating how climate change may affect rhinitis symptom prevalence.
Collectively, this dissertation contributes to our understanding of the effects of air pollution, genetic variability and climate on childhood allergic rhinitis.Medicine, Faculty of
Population and Public Health (SPPH), School of
Graduate
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Banfield, Graham Kaye. "Chemokine receptor 4 expression on T lymphocytes in allergic rhinitis." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428323.
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Coker, Heather. "Local somatic hypermutation and class switch recombination in allergic rhinitis." Thesis, King's College London (University of London), 2004. https://kclpure.kcl.ac.uk/portal/en/theses/local-somatic-hypermutation-and-class-switch-recombination-in-allergic-rhinitis(597108fa-c96d-44a7-86e5-3eb280d80ed8).html.
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An, Xue Dong, and s3059829@student rmit edu au. "Evaluation of efficacy and safety of acupuncture in the treatment of persistent allergic rhinitis." RMIT University. Health Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080701.165246.
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Background: Persistent allergic rhinitis (PAR) is a common disorder affecting substantial number of people worldwide. In Australia, allergic rhinitis affects 16% of the population. Increasingly, patients are seeking alternative therapies especially acupuncture for allergic diseases. Objective: This study aimed to evaluate the effectiveness and safety of acupuncture in the treatment of persistent allergic rhinitis. Methods: Eighty (80) subjects aged between 16 and 70 were randomly assigned to either real or sham acupuncture groups. Each patient received either real or sham acupuncture treatments twice per week for the period of eight weeks. Daily symptom scores by subjects using five-point scale was employed as the primary outcome measure to assess the severity of nasal symptoms every day. The secondary outcome measures were rhinoconjunctivitis quality of life questionnaire (RQLQ) and relief medication scores. Relief medication scores were recorded every day by subjects whereas RQLQ assessment was monitored fortnightly throughout the trial and at the end of three-month follow-up period. Results: Compared to the control group, the real acupuncture group demonstrated more improvement of nasal symptoms after eight-week treatment and significant after the follow-up periods. Significant differences between the two groups were also shown in terms of RQLQ. While there were not significantly Relief medication scores were more reduced in real acupuncture group than those in control group, although the differences were not significant. Both real and sham acupuncture treatments were well tolerated. Conclusion: The findings of this study suggest that acupuncture is potentially an effective and safe option of treatment for persistent allergic rhinitis and it may improve patients' quality of life.
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Turner, Paul Justin. "Mechanisms of hyperresponsiveness in the human nasal airway : role of kinins and nitric oxide." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325360.
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Pedroletti, Christophe. "Exhaled nitric oxide in schoolchildren with asthma /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-164-4/.
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Toll, Karin. "Pregnancy rhinitis : pathophysiological effects of oestrogen and treatment with oral decongestants /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-358-0/.
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Rajakulasingam, Karalasingam. "The effects, mechanism and actions of kinins in rhinitis and asthma." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243150.
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Diethart, Bernadette. "The use of inert hydroxypropylmethylcellulose as a remedy for allergic rhinitis." Thesis, Coventry University, 2009. http://eprints.worc.ac.uk/693/.
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Kamedien, Mogammad Sauliegh. "Incidence of atrophic rhinitis after endoscopic sinonasal surgery : a retrospective review." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/13206.
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Includes bibliographical references.Sinonasal tumours have been resected endoscopically at Groote Schuur Hospital Cape Town South Africa since 2003. Surgery, although seen as minimally invasive because no external incisions are visible, is often very aggressive and destructive to the nasal structures. The removal of the nasal turbinates has always been seen as sacrilege due to the risk of developing atrophic rhinitis. If the theory regarding developing atrophic rhinitis after a simple turbinectomy stands true, one would expect a high incidence of atrophic rhinitis after radical resection of the sinonasal structures. This has not been our experience. METHODS: The study population includes a retrospective case review of all patients that had endoscopic sinonasal tumour resection by the same surgeon between 2006 and 2010. All patients were assessed for symptoms and signs suggestive of atrophic rhinitis up to two years post resection. RESULTS: 51 patients (34M: 17F) were included in the study. Patients with residual or recurrent tumour (n=19) and patients who had received adjuvant radiotherapy (n=17) had a statistically significant chance of developing symptoms and signs suggestive of atrophic rhinitis over time. Variables such as age, gender, extent of surgery, bilateral disease, benign or malignant tumour, were not statistically significant in the development of symptoms and signs suggestive of atrophic rhinitis over time. CONCLUSIONS: Atrophic rhinitis is not more common in patients who undergo endoscopic sinonasal surgery without adjuvant therapy. However, patients with residual tumour (after debulking surgery) or recurrent tumour and those who had received adjuvant radiotherapy had a statistically significant chance of developing symptoms and signs suggestive of atrophic rhinitis over time. Keywords: atrophic rhinitis, endoscopic resection, turbinectomy, medial maxillectomy, sinonasal tumours.
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Neighbour, Helen. "Nasal and whole blood challenge models for allergic rhinitis and COPD." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/7786.
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Nasal allergen challenge (NAC) is a non-invasive model to study the mechanism of allergic rhinitis and effects of novel anti-inflammatory therapies. The repeatability and dose response of a single NAC was studied, followed by development of a daily repeat NAC model involving 4 challenges on consecutive days. However, the results of earlier published work could not be reproduced, since in nasal filter paper (FILT P) eluate in both studies there were no significant changes in levels of interleukin (IL)-4, IL-5 and IL-13. However the daily repeat NAC model did cause priming in terms of symptoms, eosinophils, and nasal lavage IL-5 and IL-13. Proposals were made for implementation of a synthetic absorptive matrix (SAM) as an alternative to Whatman's FILT P and also to deliver higher doses of allergen to the nose. Using SAM resulted in high serial levels of IL-4, IL-5 and IL-13 being detected in SAM eluates during the late phase after NAC (appendix). In cigarette smokers I requested subjects to exhale cigarette smoke through their noses, to provide a nasal cigarette smoke challenge method. FILT P is likely to distort detected levels of mediators in nasal secretions, but in FILT P eluates there were statistically significant elevations of IL-8 (p=0.01) and IL- 12p70 (p=0.02) at baseline in Chronic Obstructive Pulmonary Diseae (COPD) patients. However there were increases in nasal lavage MCP-1 at 8h in COPD patients and healthy controls following cigarette smoke (p=0.02). A cigarette smoke conditioned medium (CSCM) was employed to stimulate whole blood upregulation of CD11 b measured by flow cytometry on leukocytes. CSCM caused upregulation of neutrophil CD11 b, but this could not be inhibited by anti-oxidants. In contrast, menadione (MQ) stimulates intracellular generation of oxidants, and this caused neutrophil CD11 b upregulation that was inhibited by glutathione. Xanthine with xanthine oxidase (X+XO) generates an extracellular source of oxidants, and this caused an increase in neutrophil CD11 b on washed blood cells, that could also be inhibited by glutathione. NAC or cigarette smoke nasal challenge, as well as stimulation of human whole blood with oxidants, have potential as challenge models - but SAM should be used instead of FILT P.
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DeLeuil, Renee. "The effect of seasonal allergic rhinitis on children and their caregivers." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2006. https://ro.ecu.edu.au/theses/339.
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Introduction: Allergic diseases are highly prevalent conditions that have significant social and economic implications. Seasonal allergic rhinitis (SAR) is a common disease characterised by nasal itch and sneezing. It is estimated that the prevalence of SAR in the Australian population is around 41 %. A recent study found that the prevalence of rhinitis in Australian children is among the highest in the world. Despite this there have been no Australian studies performed to assess the impact of SAR on children and their caregivers.
Objectives: To assess the impact of SAR on the quality of life of children aged 6 to 12 years, and on caregivers of caring for a child with SAR.
Design: A prospective single cohort study was conducted. Participants included children suffering from Seasonal Allergic Rhinitis (SAR) and their caregivers who were seen at a single visit.
Setting: The study was conducted during the pollen seasons of the years 2003 and 2004. The setting for this "tudy was the Allergy/Immunology and Ear, Nose and Throat (ENT) outpatient clinics at Princess Margaret Hospital (PMH) for Children in Perth Western Australia.
Sample: Sixty children and their caregivers were recruited from the outpatient department of the major paediatric tertiary referral centre for Western Australia.
Method: Sixty children and 59 caregivers were recruited between 12 September 2003 and 5 December 2004 (during the pollen season of these years). Children were assessed using the 'Paediatric Rhinoconjunctivitis Quality of Life Questionnaire'. This questionnaire comprised five domains: nose symptoms, eye symptoms, practical problems, impact on daily activities and other symptoms of SAR. Caregivers were assessed using a previously validated questionnaire that assessed the impact of a child's SAR on their lives. This questionnaire also comprised five domains focusing on the impact of caring for a child with SAR on: social activities, routine daily activities, ability to work, ability to be productive at work and how much they worry about their child. Caregivers were also asked questions about their child’s sleeping habits. All questionnaires were completed by participants following informed consent.
Results: Results from the children's questionnaire, indicated that SAR has a significant impact on the child's daily life, in particular related to eye and nose symptoms. Children also reported feeling tired and irritable due to the symptoms of SAR. Further, children also reported sleep difficulties, which corresponded to the results from the caregiver questionnaire about their child's sleep. When children and caregiver results were analysed by severity of the child's SAR (either severe or moderate) the moderate sufferers recorded higher median scores in the eye symptom domain, the severe group recorded higher median scores in the nose symptom and practical problem domains, equivalent median scores in the Other symptoms domain and a statistically significant higher median for the activities domain (i.e. children in this group experienced a more severe impact on their activities). Caregivers also reported their child's SAR impacted on their own work and non-work activities and that their child's SAR did cause them to worry about their child's health. Caregivers reported observing their children to have poor sleep patterns, and difficulty affording the medications.
Conclusions: Results indicated that SAR does have an impact on aspects of quality of life of children and their caregivers, which concurs with findings from previous international studies. The use of the quality of life tool to assess these children provides clinically important results which suggest that it could be used effectively and routinely in the clinical setting to improve both patient outcomes and satisfaction. Further education of caregivers, health professionals and teachers is needed to improve awareness of the impact of SAR in this age group.
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Cross, Laurence Joseph Mark. "Mast cells and their role in disease states." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336723.
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Smyth, Martin Gerard. "Structural characterization of the pasteurella multocida toxin." Thesis, Birkbeck (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338390.
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Leshinsky, Jana. "Pharmacokinetics of Caspofungin Acetate in Healthy Adult Cats." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18159.
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Background Sino-orbital aspergillosis (SOA) is an invasive fungal infection with high mortality due to difficulty in its treatment. SOA is commonly caused by cryptic species in Aspergillus section Fumigati that are often resistant to antifungal triazoles but susceptible to caspofungin. Caspofungin, an echinocandin, is indicated for the treatment of refractory invasive aspergillosis in humans and has been used successfully in cats with SOA. Pharmacokinetic data is lacking in cats. Aim To determine the pharmacokinetics of caspofungin acetate and determine optimal dosing for clinical use. Materials and Methods Eight adult healthy cats were administered caspofungin (1mg/kg IV) over 1hr (Day 1). Six cats subsequently received caspofungin daily for an additional 6 days. Blood was collected at various intervals after drug administration (Day 1), before the next dose (Days 2–7), and 24h after final dosing (Day 8). Plasma caspofungin levels were determined using HPLC-tandem mass spectrometry. Nonlinear mixed-effects pharmacokinetic modelling and simulation was used to investigate caspofungin population pharmacokinetics and explore dosing regimens in cats using caspofungin minimum effective concentrations (MECs). In the final pharmacokinetic model an optimum maximum concentration (Cmax):MEC ratio of 10-20 was used to guide caspofungin efficacy. Results Using a 1mg/kg dose Cmax was 14.8µg/mL, Cmax at steady state was 19.8µg/mL, Cmin was 5µg/mL and Cmax:MEC was >20 in 42.6% cats after multiple doses. An optimal Cmax:MEC ratio was achieved in caspofungin simulations using 0.75mg/kg q24h or 1mg/kg q72h. Conclusion Mean plasma caspofungin concentrations were >1.0g/ml for the duration of the sampling period, which exceeds the MIC effective against most Aspergillus species. Based on modelling data, a daily caspofungin dose of 0.75mg/kg q24h is likely to achieve target therapeutic concentrations, meet the proposed Cmax:MEC window and provide consistent exposure between doses.
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Burte, Marthe-Emilie. "Rhinite : caractérisation et association avec la pollution atmosphérique." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLV004.
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Alors que la rhinite a un fort impact sur la santé publique, chez l’adulte, il n’existe pas de définition standardisée de la rhinite dans les études épidémiologiques. De plus, les facteurs environnementaux de la rhinite sont mal connus et, en particulier, il existe très peu d'études sur les effets à long terme de la pollution atmosphérique sur la rhinite chez l'adulte. Pour combler ces lacunes, nous avons utilisé les données de deux études épidémiologiques multicentriques européennes ayant des données détaillées sur la santé respiratoire et d'exposition annuelle individuelle à la pollution atmosphérique. Nos résultats ont montré que pour mieux caractériser la rhinite, il faut considérer l’ensemble des caractéristiques des symptômes nasaux, les comorbidités et la sensibilisation allergique, et ne pas limiter la maladie à une question ou à un test de sensibilisation allergique. Nous n'avons trouvé aucune association entre la pollution atmosphérique à long terme et l'incidence de la rhinite, mais nous avons montré que l'exposition à long terme à la pollution était associée à une augmentation de la sévérité de la rhinite, soulignant le besoin de contrôler les niveaux de pollution atmosphériqueWhereas rhinitis has an important public health impact, in adults there is no standardized definition of rhinitis in epidemiological studies. Furthermore, environmental factors of rhinitis are barely known, and in particular, there are very few studies on the effects of long-term exposure to air pollution on rhinitis in adults. To fill these gaps, we used data from two European multicentre epidemiological studies with extensive data on respiratory health and individual estimated exposures to long-term air pollution. Our findings showed that to better characterize rhinitis, one need to consider together all the characteristics of the nasal symptoms, the comorbidities and the allergic sensitization, and not to restrict the disease to one question or one allergic sensitization test. We found no association between long-term air pollution and incidence of rhinitis, but we showed that long-term exposure to air pollution is associated to an increased severity of rhinitis, emphasising that air pollution needs to be controlled
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Dedekind, Roderick. "Leitlinien zur Therapie der allergischen Rhinitis : Anwendung und Nutzen in der Praxis /." Köln, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253697.
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YAMADA, SHIN'YA, HIROTO KATO, KAORU SUGATA, MASAO KIMURA, CHIKAHIRO TERAO, MASARU MIYAO, MASASHI FURUTA, and KAZUO OZAWA. "Medical Consultation Rate of Allergic Rhinitis and Pollinosis Surveillance in Aichi, Japan." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/15938.
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Syck, Megan Paige. "Sensitivity to Oral Food Allergies in Subjects with Allergic Rhinitis and Eczema." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623167438325618.
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Secnik, Kristina. "In vitro testing for allergic Rhinitis : economic and quality of life outcomes /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486401895207609.
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Simola, Markku. "Allergic and non-allergic rhinitis : a long-term clinical follow-up study." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/simola/.
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Palframan, Roger Thomas. "Regulation of acute eosinophil mobilisation from the bone marrow." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314279.
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Teixeira, Rodrigo Ubiratan Franco 1977. "Avaliação do Peak Flow nasal inspiratório como método objetivo de mensuração do fluxo de ar nasal." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309218.
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Orientador: Everardo Andrade da CostaDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-17T21:33:45Z (GMT). No. of bitstreams: 1 Teixeira_RodrigoUbiratanFranco_M.pdf: 1228242 bytes, checksum: d6745d36e991daad043696bd5b074b70 (MD5) Previous issue date: 2011
Resumo: Para a avaliação objetiva da patência nasal são utilizados a rinometria acústica, rinomanometria e o peak flow nasal inspiratório (PFNI). Estes exames, com exceção do PFNI, são dispendiosos e complexos. Para utilização na Medicina do Trabalho e mesmo na prática clínica diária, faz-se necessário um método de mensuração simples, rápido, de baixo custo e confiável. Atualmente, os estudos tendem a correlacionar métodos que reúnem estas características, com aqueles métodos já bem documentados. Objetivos: comparar os resultados do PFNI com achados da Escala Analógica Visual (EVA), antes e após o uso de vasoconstritor nasal em indivíduos assintomáticos. Em um segundo momento, avaliar o PFNI entre indivíduos saudáveis e com queixas nasais obstrutivas. Forma de estudo: Artigo 1: Estudo de coorte em que a variável em questão é a ralação entre o PFNI e a EVA para obstrução nasal antes e após vasoconstrição nasal em indivíduos saudáveis; Artigo 2: Estudo transversal, em que a variável estudada é o comportamento do PFNI em uma população de indivíduos sem e com queixas nasais obstrutivas. Métodos: Dissertação realizada em formato alternativo composta de dois artigos. No primeiro foi feito uma correlação entre o resultado do PFNI e EVA antes e após vasoconstrição nasal de uma amostra de 60 sujeitos saudáveis. No segundo artigo foram avaliados 78 sujeitos com e sem sintomas nasais obstrutivos. Ambos estudos tiveram alocação de sujeitos de forma não randomizada. Resultados: No teste de regressão linear simples, o PFNI mostrou resultados significantes para obstrução nasal, rinorréia, prurido, espirros e lacrimejamento (p<0,001) e não apresentou significância para desvio de septo nasal (p=0,561). Encontrou-se uma correlação positiva entre PFNI e a pesquisa através da EVA (p<0,001). Houve significância estatística entre os valores encontrados no PFNI com rinite alérgica e idade (p=0,005 e p=0,023 respectivamente). O valor médio encontrado para EVA pré vasoconstrição foi de 4,1 e 2 após a vasoconstrição (variação de 44%). Em relação ao PFNI, a média encontrada foi de 151l/mim e de 178l/mim antes e após a vasoconstrição (variação de 20%). Conclusão: O PFNI mostrou ser um método confiável para detecção das alterações da patência nasal, tanto por causas obstrutivas quanto inflamatórias, com um nível de significância estatística aceitável. Apresentou forte correlação com a EVA, que é um método subjetivo muito utilizado para mensuração da obstrução nasal. É simples, fácil de manusear, pouco dispendioso e reprodutível. Por estas características descritas, pode ser usado como exame de triagem em Medicina do Trabalho. Entretanto, estudos com amostras maiores serão necessários para a normatização e sua utilização em massa
Abstract: For the objective assessment of nasal patency are used to acoustic rhinometry, rhinomanometry and nasal inspiratory peak flow (PFNI). These tests, except PFNI, are expensive and impractical. For use in occupational medicine and even in daily clinical practice, it is necessary a method for measuring simple, fast, inexpensive and reliable. Currently, studies tend to correlate methods that meet these characteristics, with other methods already well documented. Objectives: compare the results with findings PFNI EVA before and after using a nasal vasoconstrictor. In a second step, to evaluate the PFNI between healthy and obstructive nasal symptoms for allergic rhinitis. Study design: Article 1: A cohort study in which the variable is to determine the relationship between EVA Visual Analogue Scale) and PFNI for nasal obstruction before and after using a nasal vasoconstrictor. Article 2: A cross-sectional study in which the variable is the behavior of PFNI in a population of individuals. Methods: Essay held in alternate format consists of two articles. In the first article, was made a correlation between the result of PFNI and VAS before and after nasal vasoconstriction of a sample of 60 subjects. In the second article, was involve 78 subjects with and without symptoms of rhinitis. Both studies had allocation of subjects in a non-randomized. Results: In simple linear regression, the PFNI showed significant results for nasal obstruction, rhinorrhea, itching, sneezing and watery eyes (p<0.001). There was also a correlation between the presence of nasal septal deviation and PFNI (p=0.561). We found a positive correlation, the Spearman test between PFNI and research through the VAS (p<0.001). There was no statistical significance between the values found in PFNI with allergic rhinitis and age (p=0.005 and p=0.023 respectively). The mean value for VAS pre vasoconstriction was 4.1 and 2 after vasoconstriction. This represented a 44% variation between measurements. Regarding the values of PFNI, the average found in the pre measure vasoconstriction was 151l/min and 178l/min after vasoconstriction, an increase of 20%. At the moment pre vasoconstrictor, the change of a point on the average VAS represents a decrease of 3.8% in the average PFNI. In the post, each one point increase in the average value of EVA, corresponds to a decrease of 4.5% on average PFNI. Conclusion: The PFNI proved to be a reliable method for detecting larger studies are needed for a proper understanding of the method and its widespread use. changes in nasal patency by both inflammatory and obstructive causes, with an acceptable level of statistical significance, simple, easy to handle, inexpensive and reproducible. Showed strong correlation with the EVA, which is a very subjective method used to measure the nasal obstruction. Due to its characteristics described, can be used as a screening test in occupational medicine. However, larger studies are needed for a proper understanding of the method and its widespread use
Mestrado
Epidemiologia
Mestre em Saude Coletiva
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Бабич, В. С. "К вопросу о рефлексотерапии больных с инфекционно-аллергическими риносинуитами и вазомоторными ринитами." Thesis, Издательство СумГУ, 1997. http://essuir.sumdu.edu.ua/handle/123456789/25111.
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Романюк, Оксана Костянтинівна, Оксана Константиновна Романюк, Oksana Kostiantynivna Romaniuk, Н. Ф. Гончарова, and Н. Я. Кравченко. "Застосування антигістамінних препаратів у комплексному лікуванні алергічного рініту у дітей." Thesis, Вид-во СумДУ, 2005. http://essuir.sumdu.edu.ua/handle/123456789/6782.
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Загородній, Микола Петрович, Николай Петрович Загородний, and Mykola Petrovych Zahorodnii. "Алергічний риніт у дітей шкільного віку." Thesis, Видавництво СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/15916.
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Хижня, Ярослава Володимирівна, Ярослава Владимировна Хижня, and Yaroslava Volodymyrivna Khyzhnia. "Деякі аспекти лікування алергічного риніту." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32590.
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В Україні, за даними експертів Всесвітньої організації з алергії (WAO, 2008), поширеність алергічного риніту досягає 40 % . Алергічний риніт має хронічний перебіг і належить до захворювань, що суттєво погіршують якість життя пацієнтів. Несвоєчасна діагностика і лікування цього патологічного стану призводить до серйозних ускладнень з боку ЛОР-органів і сприяє розвитку бронхіальної астми.
При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32590
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Dahl, Klaus. "Effekte von Antihistaminika und topischen Glukokortikoiden auf Symptome und Entzündungsmediatoren der allergischen Rhinitis." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969130414.
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Cheng, Lei. "Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen." 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/145495.
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Kyoto University (京都大学)0048
新制・課程博士
博士(社会健康医学)
甲第11107号
社医博第2号
新制||社医||1(附属図書館)
22657
UT51-2004-L904
京都大学大学院医学研究科社会健康医学系専攻
(主査)教授 三森 経世, 教授 藤田 潤, 教授 湊 長博
学位規則第4条第1項該当
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Shaida, Azhar Mohammed. "Matrix metalloproteinases and their inhibitors in the nasal mucosa in perennial allergic rhinitis." Thesis, Queen Mary, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406469.
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