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Journal articles on the topic 'Rhino Orbito Cerebral Mucormycosis (ROCM) COVID-19 Immunocompromised Diabetes Mellitus'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Almyroudi, Maria Panagiota, Karolina Akinosoglou, Jordi Rello, Stijn Blot, and George Dimopoulos. "Clinical Phenotypes of COVID-19 Associated Mucormycosis (CAM): A Comprehensive Review." Diagnostics 12, no. 12 (2022): 3092. http://dx.doi.org/10.3390/diagnostics12123092.

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A mucormycosis surge was reported during the COVID-19 pandemic in India. A literature search until 14 July 2022, with the aim of updating COVID-19-associated mucormycosis (CAM), identified 663 studies and 88 met inclusion criteria (8727 patients). India reported 8388 patients, Egypt 208 and Europe 40. Rhino-orbito-cerebral mucormycosis (ROCM) was identified among 8082 (98.3%) patients, followed by 98 (1.2%) with pulmonary. In India, 82.6% of patients had diabetes mellitus, with 82% receiving corticosteroids. In Europe, 75% presented pulmonary CAM, 32.5% had diabetes and 40% were immunocompromi

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Raj S, Pruthvi. "Glycemic Control Variations In Covid-19 Associated Mucormycosis”." UP STATE JOURNAL OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY VOLUME 10, ISSUE II (2022): 36–41. http://dx.doi.org/10.36611/10.36611/upjohns/volume10/issue2/5.

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Background: Mucormycosis is opportunistic invasive fungal infection characterised by angioivasion, thrombosis and necrosis of the tissues. Diabetes mellitus being the commonest immunocompromised state predisposing to mucormycosis in India, a study about glycemic control in CAM (covid-19 associated mucormycosis) patients and the severity of mucormycosis was necessary so as to reduce the morbidity and mortality in CAM patients. Methods: A retrospective descriptive study was conducted between May 2021 and July 2021 at Bowring & Lady Curzon hospital. 315 patients with post-covid ROCM (rhino-or

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Puja, Priyadarshini, Kumar Jha Satyendra, and Dutta Verma Pranava. "An Observational Study to Investigate the Head and Neck Mucormycosis in Patients with Prior COVID-19 Infection." International Journal of Current Pharmaceutical Review and Research 15, no. 08 (2023): 564–68. https://doi.org/10.5281/zenodo.12570004.

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AbstractAim: The aim of the present study was to investigate the head and neck mucormycosis in patients with priorCOVID-19 infection.Methods: This cross-sectional study was conducted in the Department of Plastic Surgery, Nalanda MedicalCollege and Hospital, Patna, Bihar, India, We obtained the information by examining the data of patients whovisited Hospital with head and neck mucormycosis infection that occurred during or after the course of Covid-19infection for the period of one year. Among all 50 patients were included.Results: 30 (60) were men and 20 (40) were women, with a mean age of 56

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Patel, Seema, B. D. Bokare, A. Keche, D. Birhade, A. Kuthe, and R. Darokar. "MUCORMYCOSIS IN COVID 19- 2ND WAVE : CLINICAL PROFILE IN CENTRAL INDIA." International Journal of Advanced Research 10, no. 01 (2022): 785–89. http://dx.doi.org/10.21474/ijar01/14108.

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A sudden surge of Rhino-Orbito-Cerebral Mucormycosis (ROCM) was observed following second wave of Covid-19 in India. Diabetes mellites (DM) , steroids, hypoxia, hyperglycemia ,metabolic acidosis or Diabetic ketoacidosis, high serum iron levels, zinc supplementation, immunosuppression along with other risk factors have been found to facilitate fungal germination. Patients diagnosed with ROCM, a total of 273, were included in the study. Detailed history was noted and assessment was done. Male:Female ratio was 2.59:1. Most common presenting age group was 31 to 50 yrs (51.65%). The commonest prese

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Mishra, Sameeksha, Dhaval Bhojani, and Sudhakar Vaidya. "Presentation of mucormycosis in post Covid-19 infected patients and an approach to its management in a tertiary care centre of central India." IP Indian Journal of Anatomy and Surgery of Head, Neck and Brain 9, no. 1 (2023): 1–5. http://dx.doi.org/10.18231/j.ijashnb.2023.001.

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Background: This is a case study of 70 cases admitted in our hospital post covid-19 infection with different complaints and signs and symptoms indicating Rhino-Orbital-Cerebral-mucormycosis (ROCM). Materials and Methods: All the cases were again screened for COVID infections and comorbidities like Diabetes mellitus, Hypertension or any other immunocompromised state. The level of involvement like nasal cavity, septum, turbinates, sinuses, pterygopalatine fossa, palate, orbit or any cerebral involvement was noted and the protocol of medical and surgical management was decided in accordance to th

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Kapoor, Sahil, Poonam Kumar Saidha, Ayushi Gupta, Urvi Saini, and Sneha Satya. "COVID-19 Associated Mucormycosis with Newly Diagnosed Diabetes Mellitus in Young Males – A Tertiary Care Experience." International Archives of Otorhinolaryngology 26, no. 03 (2022): e470-e477. http://dx.doi.org/10.1055/s-0042-1748927.

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Abstract Introduction Patients with a history of or active COVID-19 infection are predisposed to the development of opportunist bacterial and fungal infections. A rising incidence of a rare occurring fungal infection earlier, called mucormycosis, has been reported in abundance across the globe since March 2021, especially in India just as the second wave of COVID-19 began, caused by the trifecta of hyperglycemia (new-onset or exacerbation of pre-existing diabetes), oxygen therapy (invasive or noninvasive ventilation), and prolonged intake of steroids. Objective The present study aimed at asses

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A., Veena H., Manjunath Bhusanoor, Bharath R., Supriya Bhakthavatchalam, and Narayanswamy Madappa. "Interesting presentations of mucormycosis in post-COVID patients." International Journal of Advances in Medicine 9, no. 6 (2022): 737. http://dx.doi.org/10.18203/2349-3933.ijam20221366.

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Most documented cases of mucormycosis have been reported in patients with uncontrolled diabetes mellitus, neutropenia, or treatment with corticosteroids. Recently, with the second wave of COVID-19, the Indian subcontinent has witnessed a dramatic rise in mucormycosis infection in patients recovered from COVID-19. This association has been documented in various case reports/case series and institutional studies, and the mortality associated with this fungal infection is emerging as a cause of concern. Pulmonary mucormycosis is the second most common form after rhino-orbito-cerebral mucormycosis

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Saberi, Hooshang, Nazi Derakhshanrad, Pedram Sedaghat, Ehsan Jaberansary, Asghar Hajipour, and Pouyan Aminishakib. "Successful Treatment of Acute Invasive Rhino-Orbito-Cerebral Mucormycosis Associated with COVID -19: Case Report and Literature Review." Iranian Journal of Neurosurgery 8, Continuous publishing (2022): 18. http://dx.doi.org/10.32598/irjns.8.18.

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Background and Aim: Mortality associated with post-coronavirus disease 2019 (COVID-19) rhino-orbital cerebral mucormycosis (ROCM) is an evolving concern. Association of COVID-19, corticosteroid therapy, and uncontrolled diabetes mellitus (DM) are considered predisposing factors for ROCM. We present two cases of successful treatment leading to patient survival for post-COVID-19, stage 4c-ROCM. Case Presentation: Two middle-aged men with poorly controlled DM were referred to our hospital for post-COVID-19 ROCM. They had received intravenous antivirals and dexamethasone as treatment in a primary

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Ponnaiah, Manickam, Sivaraman Ganesan, Tarun Bhatnagar, et al. "Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India." PLOS ONE 17, no. 8 (2022): e0272042. http://dx.doi.org/10.1371/journal.pone.0272042.

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Background In the ongoing COVID-19 pandemic, an increased incidence of ROCM was noted in India among those infected with COVID. We determined risk factors for rhino-orbito-cerebral mucormycosis (ROCM) post Coronavirus disease 2019 (COVID-19) among those never and ever hospitalized for COVID-19 separately through a multicentric, hospital-based, unmatched case-control study across India. Methods We defined cases and controls as those with and without post-COVID ROCM, respectively. We compared their socio-demographics, co-morbidities, steroid use, glycaemic status, and practices. We calculated cr

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Sontakke, Ashwini Y., Vaishnavi V. Kulkarni, Nitin N. Nandanvankar, and Sachin Totawar. "Anesthesia Management of COVID-19 associated Rhino-Orbito-Cerebral Mucormycosis: A Prospective Observational Study." Perspectives in Medical Research 12, no. 1 (2024): 12–18. http://dx.doi.org/10.47799/pimr.1201.03.

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Abstract Background: Fungal infections (mucormycosis) have been reported as co-infection as well as opportunistic infection during and after COVID-19 (Coronavirus disease), involving the paranasal air sinuses with a high risk of morbidity and mortality. Considering the ongoing situation of COVID-19 associated with mucormycosis, we presented our experience of 110 patients being, or having previously been COVID -19 positive. Methods: This study included 110 patients in which surgical resection was done for Rhino-orbito-cerebral mucormycosis (ROCM) under general anesthesia and observed for 30 day

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Gupta, Keshav. "RHINO-ORBITO-CEREBRAL MUCORMYCOSIS (BLACK FUNGUS) IN COVID 19 PATIENTS." UP STATE JOURNAL OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY Volume 9, upjohns/volume9/Issue2 (2021): 27–31. http://dx.doi.org/10.36611/upjohns/volume9/issue2/5.

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ABSTRACT BACKGROUND Mucormycosis (Black fungus) is a designated as a rare, rapidly progressive fatal disease of immunocompromised caused by saprophytic fungus of family mucorales. Early diagnosis with prompt medical and surgical treatment is the only tool available. Rhino-orbito-cerebral is the most common subtype. In India we saw a sudden rise in mucormycosis cases during second wave of COVID 19. This necessitated a systematic review of epidemic of mucormycosis in COVID 19. METHODS A Retrospective multi-centric study was conducted at various Government and Private Hospitals of Western UP comp

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KUMAR, S., S. KATPAR, M. DIN, TU NISA, T. KHAN, and M. HUSSAIN. "SPECTRUM OF MUCORMYCOSIS CASES ASSOCIATED WITH COVID 19, PRESENTING WITH NEW MANAGEMENT PROTOCOL FROM ORAL & MAXILLOFACIAL SURGICAL UNIT OF A PUBLIC SECTOR TERTIARY CARE HOSPITAL PAKISTAN." Pakistan Journal of Intensive Care Medicine 4, no. 02 (2024): 39. https://doi.org/10.54112/pjicm.v4i02.39.

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Background: This original and pioneer national clinical study highlights the surge of COVID-19-associated mucormycosis, a life-threatening fungal infection with high morbidity and mortality, particularly in diabetics and immunocompromised patients. It underscores the critical role of early diagnosis and aggressive surgical intervention in improving patient outcomes. Objective: To present the clinical features of Rhino-orbital cerebral mucormycosis (ROCM) cases managed and its association with the COVID-19 Pandemic. Study Design: Descriptive cross-sectional. Duration of Study: December 2022 to

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Kishve, Sanjay, Prajakta Kishve, and G. Pavan Kalyan Reddy. "Understanding the spectrum of rhino-orbito-cerebral mucormycosis: clinical presentation, management strategies, and prognostic markers in an Indian tertiary care setting." International Journal of Research in Medical Sciences 12, no. 11 (2024): 4157–61. http://dx.doi.org/10.18203/2320-6012.ijrms20243365.

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Background: Rhino-orbito-cerebral mucormycosis (ROCM) is an angio-invasive fungal infection characterized by tissue infarction and necrosis. Its incidence has surged, particularly in the backdrop of the ongoing COVID-19 pandemic, necessitating a comprehensive understanding of its clinical presentation, management outcomes, and prognostic factors. Methods: This retrospective cohort study analyzed data from 100 ROCM patients admitted to a tertiary care hospital in India between February 2021 and September 2021. Clinical presentations, laboratory investigations, treatment outcomes, and adverse re

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C., Sunil K., Praveen Kumar B. Y., Ramesh Bhoomannavar, and Rishabh Jain. "Open surgical approach to management of rhino-orbito-cerebral mucormycosis." International Journal of Otorhinolaryngology and Head and Neck Surgery 8, no. 1 (2021): 64. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20214902.

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<p class="abstract"><strong>Background: </strong>Since December 2019, when novel corona virus (COVID 19) was reported, it has spread widely to cause a pandemic. Rhino-orbito-cerebral Mucormycosis (ROCM), an opportunistic fungal infection caused by the order Mucorales and class Zygomycetes has led to an epidemic in our country.</p><p class="abstract"><strong>Methods: </strong>This prospective cross sectional study was conducted at a 1200 bed tertiary care teaching hospital in Mysore. All patients of ROCM who presented to us for treatment were selected f

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Srivastava, Mohit, Keshav Gupta, and Veenita Singh. "Rhino-orbito-Cerebral mucormycosis during COVID 19 pandemic in western Uttar Pradesh India." IP Journal of Otorhinolaryngology and Allied Science 4, no. 3 (2021): 94–97. http://dx.doi.org/10.18231/j.ijoas.2021.019.

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Mucormycosis (Black fungus) is a designated as a rare, rapidly progressive fatal disease of immunocompromised caused by saprophytic fungus of family mucorales. Early diagnosis with prompt medical and surgical treatment is the only tool available. Rhino-orbito-cerebral is the most common subtype. In India we saw a sudden rise in mucormycosis cases during second wave of COVID 19. This necessitated a systematic review of epidemic of mucormycosis in COVID 19.A Retrospective multi-centric study was conducted comprising of 51 cases of Rhino-orbito-cerebral mucormycosis with present or recent COVID19

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A., Geetha, Anjaneyulu K., Prasad Y.M.S., and Manasa K.V. "A Clinical Study on Mucormycosis Done During the Covid Pandemic in the Year 2021." International Journal of Pharmaceutical and Clinical Research 15, no. 8 (2023): 1368–72. https://doi.org/10.5281/zenodo.11521846.

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<strong>Background: </strong>Mucormycosis is a angioinvasive fungal infection, mainly affecting patients with uncontrolled diabetes mellitus, those on chemotherapy and those who are suffering from a chronic illness. There has been a remarked increase in the incidence of Rhino-orbito-cerebral mucormycosis (ROCM) in association with the 2nd wave of COVID. <strong>Methods: </strong>The study was conducted in a tertiary care hospital. Data was collected from 200 cases of Rhino-orbito-cerebral mucormycosis which were admitted and treated in the period from June 1st to august 31st of

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Srivastava, Mohit, Keshav Gupta, and Veenita Singh. "Rhino-orbito-cerebral mucormycosis (black fungus) in covid 19 patients in western Uttar pradesh India." Journal of Otolaryngology-ENT Research 13, no. 3 (2021): 79–82. http://dx.doi.org/10.15406/joentr.2021.13.00495.

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Mucormycosis (Black fungus) is a designated as a rare, rapidly progressive fatal disease of immunocompromised caused by saprophytic fungus of family mucorales. Early diagnosis with prompt medical and surgical treatment is the only tool available. Rhino-orbito-cerebral is the most common subtype. In India we saw a sudden rise in mucormycosis cases during second wave of COVID 19. This necessitated a systematic review of epidemic of mucormycosis in COVID 19. A Retrospective multi-centric study was conducted comprising of 51 cases of Rhino-orbito-cerebral mucormycosis with present or recent COVID1

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Nwadinigwe, Chimezie Finian, Mateus Sakundarno Adi, Budi Laksono, and Dwi Sutiningsih. "Rhino-Orbito-Cerebral Mucormycosis (ROCM): An Observational Case Report of Covid-19 Positive Patients Admitted in Intensive Care Unit of Community Hospital in South India." Jurnal Epidemiologi Kesehatan Komunitas 8, no. 1 (2023): 1–5. http://dx.doi.org/10.14710/jekk.v8i1.16620.

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Background: Rhino-orbito-cerebral mucormycosis (ROCM) increasing incidence in the setting of COVID-19 in India and elsewhere has become a matter of immediate concern. In this observational case report we have observed the signs and symptoms of ROCM among coronavirus positive patients with reference to “Mucor code “as reported by Honavar SG 2021, we have reported cases been admitted to ICU for <2weeks in a community hospital in South India. Method: Patient informed consent was taken, Patient’s data (Medical record, medication charts, daily report) were collected using a designed data collect

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Dhawan, Vaishali Bodhraj, and Megha Manoj. "Rapidly Progressing Rhino-orbito-cerebral Mucormycosis with Concomitant Pulmonary Mucormycosis in a Post-COVID-19 Diabetic Subject." Indian Journal of Public Health 68, no. 1 (2024): 137–39. http://dx.doi.org/10.4103/ijph.ijph_237_23.

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Summary Invasive fungal sinusitis is a highly lethal infection in an immunocompromised population that can spread rapidly to involve the adjacent structures by direct invasion or through vascular invasion. Involvement of cerebral parenchyma by vascular invasion is a devastating complication in these patients which may lead to vasculitis, thrombus formation, cerebritis, or abscess formation. Here, we present a case of a young male with uncontrolled diabetes mellitus who initially presented with COVID-19 lung disease and later developed sinonasal mucormycosis complicated with left orbital cellul

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Ashish, Kumar, Dhillon Sagar, Singh Saloni, and Choudhary Rajendra. "A Study of Causation and Extent of Rhino-Orbito-Cerebral Spread of Mucormycosis in COVID-19 Treated Patients at a Tertiary Care Hospital in North India." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 854–59. https://doi.org/10.5281/zenodo.11427952.

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<strong>Background: </strong>The COVID-19 pandemic has resulted in immense devastation, with a staggering death toll of over three million worldwide. As a consequence, there has been a notable rise in opportunistic infections, with one of the most alarming being COVID-19 associated Mucormycosis (CAM). The lack of comprehensive guidelines for screening and managing this condition, coupled with delayed diagnoses and poor prognoses, have heightened concerns among healthcare professionals that an epidemic of CAM may occur alongside the existing pandemic. <strong>Method: </strong>Twe

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Tuncer, Bilge, Yasemin Akcaalan, Sumeyye Kocagil, et al. "Anesthetic Management of Mucormycosis Cases Requiring Surgical Debridement." Journal of Anesthesiology and Reanimation Specialists' Society 32, no. 2 (2024): 75–80. http://dx.doi.org/10.54875/jarss.2024.48802.

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Objective: Mucormycosis is a rare, progressive, and life-threatening fungal infection that occurs in immunocompromised patients. In the present study, we aimed to evaluate the perioperative challenges in the anesthetic management of mucormycosis patients. Methods: Patients over 18 years of age who underwent surgery for mucormycosis within a 3-year period between January 1, 2020 and December 31, 2022 were included in the study. Perioperative records were retrospectively evaluated. Results: During this period, 25 of 47 cases of mucormycosis were surgically treated. Data from these 25 cases were

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Pratik, Borawake* Siddhi Gavali Akash Doke. "Mucormycosis: Diagnosis, Treatment And Future Direction." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 1033–41. https://doi.org/10.5281/zenodo.11063473.

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Mucormycosis is a difficult condition to diagnose and treat.  In developed nations, haematological malignancies are the most prevalent underlying disease, uncontrolled diabetes is the most common condition. Pulmonary mucormycosis is reportedly associated radiologically with multiple (≥10) nodules and pleural effusion. An additional observation from a computerized tomography (CT) scan appears to be the reverse halo sign, which suggests the presence of mucormycosis. Diagnosis relies heavily on culture and direct microscopy on histopathology.  Mucormycosis is a rare disease with a hi

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Allaw, Fatima, Johnny Zakhour, Sarah B. Nahhal, et al. "Mucormycosis: A 14-Year Retrospective Study from a Tertiary Care Center in Lebanon." Journal of Fungi 9, no. 8 (2023): 824. http://dx.doi.org/10.3390/jof9080824.

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Mucormycosis (MCM) is a serious invasive fungal disease (IFD) that is associated with high mortality, particularly in immunocompromised patients. A global surge in MCM cases was reported with the COVID-19 pandemic. We analyzed all recorded cases of MCM at the American University of Beirut Medical Center (AUBMC), a tertiary care center in Lebanon, over 14 years. We aimed to identify the incidence, seasonal variation, clinical characteristics of the patients, and predictors of mortality. We conducted a retrospective chart review between 1 January 2008 and 1 January 2023. All patients with proven

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Seema, Patel, Bokare A. Keche D. Birhade B.D, and Kuthe and R. Darokar A. "MUCORMYCOSIS IN COVID 19- 2ND WAVE : CLINICAL PROFILE IN CENTRAL INDIA." March 3, 2022. https://doi.org/10.5281/zenodo.6324747.

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A sudden surge of Rhino-Orbito-Cerebral Mucormycosis (ROCM) was observed following second wave of Covid-19 in India. Diabetes mellites (DM) , steroids, hypoxia, hyperglycemia ,metabolic acidosis or Diabetic ketoacidosis, high serum iron levels, zinc supplementation, immunosuppression along with other risk factors have been found to facilitate fungal germination. Patients diagnosed with ROCM, a total of 273, were included in the study. Detailed history was noted and assessment was done. Male:Female ratio was 2.59:1. Most common presenting age group was 31 to 50 yrs (51.65%). The commonest prese

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Venkateswarlu, Prudhvi, Latha Latha, and Mounika Mounika. "MANAGEMENT AND FUNCTIONAL OUTCOME OF SARS COVID-19 INDUCED RHINO ORBITAL CEREBRAL MUCORMYCOSIS." INDIAN JOURNAL OF APPLIED RESEARCH, March 1, 2023, 21–24. http://dx.doi.org/10.36106/ijar/9106678.

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Background: Rhino-orbital cerebral mucormycosis(ROCM) is an uncommon infection caused by the angiotropic fungus belonging to the order Mucorales and has high morbidity and mortality despite treatment. Rhino-orbital cerebral mucormycosis almost always occurs in immunocompromised hosts, including patients with uncontrolled diabetes mellitus, hematologic cancers, and solid organ or hematopoietic stem cell transplants. The suspicion or diagnosis of rhino-orbital cerebral mucormycosis triggers a medical as well as surgical emergency with the delay in treatment, increasing morbidity and mortality. A

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Singhal, Annu, Shikha Jain, Swati Sharma, Vivek Cherumanalil Kottiyath, and Girish Khandelwal. "A multicentric observational study of imaging findings in COVID-19-related rhino-orbito-cerebral mucormycosis: a new Pandora’s box." Egyptian Journal of Radiology and Nuclear Medicine 52, no. 1 (2021). http://dx.doi.org/10.1186/s43055-021-00631-w.

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Abstract Background There is a sudden rise of fungal infection with corona virus disease. This is attributed to the immunomodulation by the disease and the drugs used, diabetes mellitus, steroid use, oxygen inhalation using dirty water, use of zinc and iron supplements, etc. Early diagnosis and prompt medical and surgical intervention is the mainstay of treatment. This can greatly reduce the high morbidity and mortality associated with this disease. The objective of the study is to describe the imaging findings of acute invasive rhino-orbito-cerebral mucormycosis (ROCM) in 25 patients with sev

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Pai, Vivek, Rima Sansi, Ritesh Kharche, Sridevi Chaitanya Bandili, and Bhujang Pai. "Rhino-orbito-cerebral Mucormycosis: Pictorial Review." Insights into Imaging 12, no. 1 (2021). http://dx.doi.org/10.1186/s13244-021-01109-z.

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AbstractMucormycosis (MCR) is a fulminant, potentially lethal, opportunistic fungal infection. Diabetes, immunocompromised states and elevated serum iron levels are the most important risk factors for contracting MCR infection. Recently, MCR co-infections have been observed in patients with COVID-19 disease owing to a complex interplay of metabolic factors and corticosteroid therapy. Rhino-orbito-cerebral mucormycosis (ROCM) is the most common clinical form of MCR infection and refers to infection of the nasal cavities, paranasal sinuses, neck spaces, orbits and intracranial structures. Sinona

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Saleeb, Mina Fayez, Sabry Magdy Sabry, Mohammad Salah Mahmoud, and Mena Maher Nassif. "Risk factors affecting outcome of rhino-orbital-cerebral mucormycosis in COVID-19 patients." Egyptian Journal of Otolaryngology 39, no. 1 (2023). http://dx.doi.org/10.1186/s43163-023-00406-2.

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Abstract Background Mucormycosis is a serious life-threatening fungal infection that recently made severe sudden and devastating surge during the second wave of the COVID-19 epidemic with a mortality rate of up to 50%. Although the causality link between COVID-19 and rhino-orbito-cerebral mucormycosis (ROCM) remains unclear, many factors including poor diabetes control, high doses of steroids, viral-induced lymphopenia, and cytokine storm have been attributed to ROCM in patients with COVID-19. Orienting to risk factors and early recognition of this potentially fatal opportunistic infection is

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Agrawal, Alka, Neetu Kori, Gulshan Madhpuriya, Prakhar Nigam, and Simran Agrawal. "Comparison of MRI Findings in Diabetic and Nondiabetic Patients with Rhino-Orbito-Cerebral Mucormycosis." Annals of the National Academy of Medical Sciences (India), December 2, 2022. http://dx.doi.org/10.1055/s-0042-1757740.

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Abstract Objective Rhino-orbito-cerebral mucormycosis (ROCM) has emerged as a key concern during the period of coronavirus disease 2019 (COVID-19) pandemic. Diabetes mellitus is a known risk factor for invasive fungal infection. The aim of this article was to study and compare the radiological features of COVID-19-associated ROCM between diabetic and nondiabetic patients using magnetic resonance imaging. Materials and Methods A retrospective observational study comprising 78 diabetics and 40 nondiabetics who developed ROCM after COVID-19 was conducted. The imaging data of both groups were anal

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Singh, Shivam, Pragati Basera, Aditya Anand, and Ahmad Ozair. "COVID-19-Associated Mucormycosis in a Tertiary Care Hospital in India: A Case Series." Cureus, August 11, 2022. https://doi.org/10.7759/cureus.27906.

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Mucormycosis is a disease that usually occurs in immunocompromised patients or those with uncontrolled diabetes mellitus. The second wave of the coronavirus disease 2019 (COVID-19) pandemic in India was accompanied by an unexpected rise in mucormycosis cases, ranging from the most commonly occurring Rhino-orbital-cerebral mucormycosis (ROCM) to rare cases of pulmonary and gastrointestinal mucormycosis. The majority of cases that presented to our hospital were individuals with underlying diabetes mellitus who received steroids for COVID-19 before being diagnosed with mucormycosis. In this case

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Taneja, Juhi, Kuhu Chatterjee, Jaseetha Sasidharan, et al. "Post -COVID -19 rhino -orbito- cerebral mucormycosis -a clinicomycological study from North India." Medical Mycology, July 13, 2023. http://dx.doi.org/10.1093/mmy/myad067.

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Abstract The second wave of Coronavirus Disease 2019 (COVID-19), during the early 2021, lead to devastating outbreak of mucormycosis in India. This study aimed to determine the etiology, clinical features, co morbidities and risk factors of rhino -orbito -cerebral mucormycosis (ROCM) and antifungal susceptibility pattern for the isolates. The study included all suspected cases of ROCM in post COVID- 19 patients attending hospital from May to December 2021. 70 patients were diagnosed with mucormycosis during the study period. The commonest presentation was rhino-orbital and rhino-orbito-cerebra

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Madan, Siddharth, Rekha Yadav, Jolly Rohatgi, et al. "Demographic and Clinical Profile of Patients Presenting with COVID-19-Associated Rhino-orbito-cerebral Mucormycosis at a Tertiary Care Center." Annals of the National Academy of Medical Sciences (India), December 8, 2022. http://dx.doi.org/10.1055/s-0042-1757894.

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Abstract Objectives Individuals affected with rhino-orbito-cerebral mucormycosis (ROCM) associated with coronavirus disease 2019 (COVID-19) increased enormously in northern India during the second wave of the novel coronavirus disease. This study determined the demographic and clinical profile including the risk factors in patients presenting to a tertiary care hospital in northern India. Materials and Methods This is a descriptive study involving patients admitted with COVID-19-associated ROCM and were managed from May 2021 to 20th July 2021. Statistical Analysis The data was analyzed using S

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Erum Shahzadi, Zarnab Khalid, Sarfraz Latif, Zia-Us-Salam Qazi, Sohail Ahmed Malik, and IKram-Ullah. "RHINO-ORBITO-CEREBRAL MUCORMYCOSIS (ROCM), GRAY AREAS OF MANAGEMENT - A STUDY PRESENTING HIGH INCIDENCE WITH COVID-19." Journal of Ayub Medical College Abbottabad 36, no. 4 (Suppl 1) (2024). https://doi.org/10.55519/jamc-s4-13630.

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Background: Rhino-Orbito-Cerebral Mucormycosis is caused by fungi belonging to the Mucorales family, with Rhizopus arrhizus being the most common causative agent. It is a fatal and debilitating condition that is prevalent in developing countries, with a mortality rate ranging from 50% to 85%, reaching 100% in disseminated or untreated cases. The diagnosis is based on tissue histopathology and culture confirmation. Some studies have assessed the efficacy of antifungal regimens. Limited knowledge of the disease, its diverse presentations, delays in early diagnosis, and insufficient efforts to id

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Lakshmanan, Jothisri, Shukla Das, and Narendra Pal Singh. "P430 Correlation of microscopy and culture findings with serum ferritin level for the diagnosis of rhino-orbito-cerebral Mucormycosis during COVID-19 pandemic—a study from tertiary care hospital India." Medical Mycology 60, Supplement_1 (2022). http://dx.doi.org/10.1093/mmy/myac072.p430.

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Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Rhino-orbito-cerebral Mucormycosis (ROCM) is a fulminant manifestation with high morbidity and mortality rates. It was considered to be a notifiable disease during COVID-19 pandemic in India as per ICMR. Hence, this study was conducted to correlate microscopy (KOH) and culture findings with serum ferritin levels for the cases with suspected ROCM with diabetes mellitus (DM) as a primary risk factor presented to tertiary care hospitals in India during COVID-19 pandemic. Methods A prospective study was conducted during t

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Gogineni, Hyma, Wonhee So, Kenneth Mata, and John N. Greene. "Multidisciplinary approach in diagnosis and treatment of COVID-19-associated mucormycosis: a description of current reports." Egyptian Journal of Internal Medicine 34, no. 1 (2022). http://dx.doi.org/10.1186/s43162-022-00143-7.

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Abstract Background We reviewed the epidemiology, risk factors, pathophysiology, and clinical presentations of coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM), then discussed the importance of rapid diagnosis and treatment facilitated by multidisciplinary approach. Main body India has reported world’s highest number of CAM cases where Rhizopus arrhizus was the most predominant etiology. CAM caused by Rhizopus microsporus was the most common from the rest of the world. Multiple risk factors for CAM were identified including diabetes mellitus, inappropriate corticosteroid use,

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Swaika, Sweta, and Akshara Gupta. "SPECTRUM OF MAGNETIC RESONANCE IMAGING FINDINGS IN RHINO-ORBITO-CEREBRAL MUCORMYCOSIS PATIENTS DURING SECOND WAVE OF COVID-19 INFECTION IN A TERTIARY CARE HOSPITAL – A PROSPECTIVE STUDY." PARIPEX INDIAN JOURNAL OF RESEARCH, July 15, 2021, 43–46. http://dx.doi.org/10.36106/paripex/9503773.

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Introduction- Mucormycosis is a lethal intrusive opportunistic fungal infection with increased morbidity and mortality. Its most common form is Rhino-Orbital-Cerebral Mucormycosis (ROCM). It has been described more in immunosuppressed people and currently in patients with recent history of/ concomitant Covid-19 infection. Magnetic Resonance Imaging (MRI) has been used to delineate extent of infection and spread and preoperative planning. MRI shows varied T1 and T2 signal intensity lesions with nonenhancement in necrosed tissues and extension of infection into adjacent structures. This prospect

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Madan, Siddharth, Shelly Shelly, Rekha Yadav, et al. "A Study on the Impact of Diabetes Mellitus on the Severity of COVID-19-Associated Mucormycosis." Annals of the National Academy of Medical Sciences (India), February 22, 2023. http://dx.doi.org/10.1055/s-0042-1759890.

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Abstract Objectives: Diabetes mellitus (DM) seems the most common predisposing factor for rhino-orbito-cerebral mucormycosis (ROCM). This study aimed to study the impact of DM on the severity of COVID-19-associated ROCM (CAM). Methods: This was a retrospective analytical study performed over a period of 3 months to assess the impact of DM on the severity of CAM in 100 patients and association of clinical correlates of DM with severity of CAM. Statistical analysis: The data collected using the study tools were converted into a computer-based spreadsheet and analyzed. The statistical analysis co

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Nada, Manisha, Monika Dahiya, Jitender Phogat, Aakash Sharma, Manoj Shettigar, and Surender Kumar. "Retinal Manifestations in Rhinoorbito-cerebral Mucormycosis: A Cross-sectional Study." JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2022. http://dx.doi.org/10.7860/jcdr/2022/55112.16590.

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Introduction: Rhino-orbito-cerebral Mucormycosis (ROCM) is an uncommon but devastating fungal infection caused by Mucoraceae family fungi, which are angiotropic and filamentous, with significantly high morbidity and mortality despite treatment. Post Coronavirus Disease-2019 (COVID-19), there was a sudden surge in ROCM cases nationwide due to immunologically and metabolically compromised status. Aim: To describe retinal manifestations in ROCM in a tertiary eye care centre of Northern India. Materials and Methods: An analytic, cross-sectional and hospitalbased study was conducted in Regional Ins

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S. Date, Purva, Swati S. Hire, Neha H. Shah, et al. "BLIND-SIDED BY BLACK FUNGUS: CRAO IN CAM." GLOBAL JOURNAL FOR RESEARCH ANALYSIS, May 15, 2023, 36–39. http://dx.doi.org/10.36106/gjra/4207627.

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Importance: There has been an outbreak of COVID-19 associated rhino-orbito-cerebral mucormycosis (CAM) in many parts of developing world. The clinical prole, mortality rate, risk factors associated with it has been studied. A case series highlighting association of Central Retinal Artery Occlusion (CRAO) in CAM has not been reported yet. To report a case series of Central Retinal Artery Occlusion (CRAO) in 15 pati Objective: ents with history of COVID19 infection associated mucormycosis (CAM). This is a retrospective observational study of Design: 15 cases of rhino-cerebroorbital mucormycosis

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Taneja, Juhi, Kuhu Chatterjee, Jaseetha Sasidharan, Zafar Abbas, Anil K. Rai, and Bhabatosh Das. "P086 Clinical outcome and in vitro antifungal susceptibility of clinical isolates of rhino-orbito-cerebral mycosis associated with post COVID 19 from North India." Medical Mycology 60, Supplement_1 (2022). http://dx.doi.org/10.1093/mmy/myac072.p086.

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Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives This study aimed primarily to determine the etiology, clinical features, and comorbidities of patients with rhino-orbito-cerebral mycosis. Secondly, antifungal susceptibility pattern of the isolates and lineage by ITS-sequencing was also studied. Methods The study was conducted from May to December 2021 on all suspected cases of rhino-orbito-cerebral mycosis in post-COVID-19 patients at a tertiary care center. Data pertaining to demographics, recent COVID-19 infection, clinical features, comorbidities, laboratory, rad

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Patil, Rajashri, Jyoti Ajagunde, Sameena Khan, Sriram Kannuri, Nageswari Gandham, and Sahjid Mukhida. "Rhino-orbital cerebral mycosis: a case series of non-mucorales in COVID patients." Access Microbiology 5, no. 10 (2023). http://dx.doi.org/10.1099/acmi.0.000575.v4.

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Introduction. Rhino-Orbito-cerebral mycoses are not only caused by Aspergillus spp. and Zygomycetes spp. but also can be associated with other rare species such as Neurospora spp., Cladosporium spp. and Fusarium spp. Mucormycosis is associated causatively with immunocompromised states, for example patients with comorbidities such as diabetes mellitus. Clinical symptoms of coronavirus disease (COVID) and mucormycosis in tandem are critical and relentless, frequently with no life-saving treatment. Case series. We report three patients with COVID-19 infection, who during the course of treatment d

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