Relevant bibliographies by topics / Rho GTPases. Cells Fibroblasts

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Rho GTPases. Cells Fibroblasts'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Rho GTPases. Cells Fibroblasts"

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Schwarz, Kerstin, Frank Aschenbrenner, Brigitte Ruster, et al. "Novel Role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in Adhesion and Migration of 32D Myeloid Progenitor Cells." Open Hematology Journal 6, no. 1 (2012): 1–7. http://dx.doi.org/10.2174/1874276901206010001.

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Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic hematopoietic progenitor cells (HPC) to fibronectin and migration in a three-dimensional stromal cell model. Here, we identified the Ras GTPase-Activating Protein SH3 Domain-Binding Protein (G3BP) as a target gene of Rho GTPases and analysed its role in regulating HPC motility. Overexpression of G3BP significantly enhanced adhesion of murine 32
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Sander, Eva E., Jean P. ten Klooster, Sanne van Delft, Rob A. van der Kammen, and John G. Collard. "Rac Downregulates Rho Activity." Journal of Cell Biology 147, no. 5 (1999): 1009–22. http://dx.doi.org/10.1083/jcb.147.5.1009.

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Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange factor Tiam1 functions as a specific activator of Rac but not Cdc42 or Rho in NIH3T3 fibroblasts. Activation of Rac by Tiam1 induces an epithelial-like morphology with functional cadherin-based adhesions and inhibits migration of fibroblasts. This epithelial phenotype is characterized by Rac-mediated effects on Rho activity. Transient PDGF-induced as well as sustained Rac activation by Tiam1 or V12Rac downregulate Rho activity. We found that Cdc42 also downregulates Rho
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Kurokawa, K., T. Nakamura, K. Aoki, and M. Matsuda. "Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells." Biochemical Society Transactions 33, no. 4 (2005): 631–34. http://dx.doi.org/10.1042/bst0330631.

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Rho-family GTPases regulate various aspects of cell function by controlling cytoskeletal changes; however, their spatial regulation within the cells remains largely unknown. To understand this regulation, we have studied the spatiotemporal activity of Rho-family GTPases in migrating cells and growth factor-stimulated cells by using probes based on the principle of fluorescence resonance energy transfer. In migrating fibroblasts and epithelial cells, the level of RhoA activity is high both at the contractile tail and at the leading edge, whereas Rac1 and Cdc42 activities are high only at the le
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Grande-García, Araceli, Asier Echarri, Johan de Rooij, et al. "Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases." Journal of Cell Biology 177, no. 4 (2007): 683–94. http://dx.doi.org/10.1083/jcb.200701006.

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Development, angiogenesis, wound healing, and metastasis all involve the movement of cells in response to changes in the extracellular environment. To determine whether caveolin-1 plays a role in cell migration, we have used fibroblasts from knockout mice. Caveolin-1–deficient cells lose normal cell polarity, exhibit impaired wound healing, and have decreased Rho and increased Rac and Cdc42 GTPase activities. Directional persistency of migration is lost, and the cells show an impaired response to external directional stimuli. Both Src inactivation and p190RhoGAP knockdown restore the wild-type
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Aiastui, Ana, M. Graciela Pucciarelli, and Francisco García-del Portillo. "Salmonella enterica Serovar Typhimurium Invades Fibroblasts by Multiple Routes Differing from the Entry into Epithelial Cells." Infection and Immunity 78, no. 6 (2010): 2700–2713. http://dx.doi.org/10.1128/iai.01389-09.

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ABSTRACT Fibroblasts are ubiquitous cells essential to tissue homeostasis. Despite their nonphagocytic nature, fibroblasts restrain replication of intracellular bacterial pathogens such as Salmonella enterica serovar Typhimurium. The extent to which the entry route of the pathogen determines this intracellular response is unknown. Here, we analyzed S. Typhimurium invasion in fibroblasts obtained from diverse origins, including primary cultures and stable nontransformed cell lines derived from normal tissues. Features distinct to the invasion of epithelial cells were found in all fibroblasts te
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Fueller, Florian, Martin O. Bergo, Stephen G. Young, Klaus Aktories, and Gudula Schmidt. "Endoproteolytic Processing of RhoA by Rce1 Is Required for the Cleavage of RhoA by Yersinia enterocolitica Outer Protein T." Infection and Immunity 74, no. 3 (2006): 1712–17. http://dx.doi.org/10.1128/iai.74.3.1712-1717.2006.

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ABSTRACT The bacterial toxin Yersinia outer protein T (YopT) is a cysteine protease that cleaves Rho GTPases immediately upstream of a carboxyl-terminal isoprenylcysteine. By clipping off the lipid anchor, YopT releases Rho GTPases from membranes, resulting in rounding up of mammalian cells in culture. The proteolytic activity of YopT depends on the isoprenylation of the cysteine within the carboxyl-terminal CaaX motif, a reaction carried out by geranylgeranyltransferase type I. The CaaX motif (where “a” indicates aliphatic amino acids) of Rho proteins undergoes two additional processing steps
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DerMardirossian, Céline, Gabriel Rocklin, Ji-Yeon Seo, and Gary M. Bokoch. "Phosphorylation of RhoGDI by Src Regulates Rho GTPase Binding and Cytosol-Membrane Cycling." Molecular Biology of the Cell 17, no. 11 (2006): 4760–68. http://dx.doi.org/10.1091/mbc.e06-06-0533.

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Rho GTPases (Rac, Rho, and Cdc42) play important roles in regulating cell function through their ability to coordinate the actin cytoskeleton, modulate the formation of signaling reactive oxidant species, and control gene transcription. Activation of Rho GTPase signaling pathways requires the regulated release of Rho GTPases from RhoGDI complexes, followed by their reuptake after membrane cycling. We show here that Src kinase binds and phosphorylates RhoGDI both in vitro and in vivo at Tyr156. Analysis of Rho GTPase–RhoGDI complexes using in vitro assays of complexation and in vivo by coimmuno
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Guo, Fukun, and Yi Zheng. "Involvement of Rho Family GTPases in p19Arf- and p53-Mediated Proliferation of Primary Mouse Embryonic Fibroblasts." Molecular and Cellular Biology 24, no. 3 (2004): 1426–38. http://dx.doi.org/10.1128/mcb.24.3.1426-1438.2004.

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ABSTRACT The Rho family GTPases Rac1, RhoA, and Cdc42 function as molecular switches that transduce intracellular signals regulating gene expression and cell proliferation as well as cell migration. p19Arf and p53, on the other hand, are tumor suppressors that act both independently and sequentially to regulate cell proliferation. To investigate the functional interaction and cooperativeness of Rho GTPases with the p19Arf-p53 pathway, we examined the contribution of Rho GTPases to the gene transcription and cell proliferation unleashed by deletion of p19Arf or p53 in primary mouse embryo fibro
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Katoh, Hironori, Amane Harada, Kazutoshi Mori, and Manabu Negishi. "Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers." Molecular and Cellular Biology 22, no. 9 (2002): 2952–64. http://dx.doi.org/10.1128/mcb.22.9.2952-2964.2002.

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ABSTRACT Rho family small GTPases are key regulators of the actin cytoskeleton in various cell types. The Rnd proteins, Rnd1, Rnd2, and Rnd3/RhoE, have been recently identified as new members of the Rho family of GTPases, and expression of Rnd1 or Rnd3 in fibroblasts causes the disassembly of actin stress fibers and the retraction of the cell body to produce extensively branching cellular processes. Here we have performed a yeast two-hybrid screening by using Rnd1 as bait and identified a novel protein that specifically binds to Rnd GTPases. We named this protein Socius. Socius directly binds
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Qu, Jian, Marta S. Cammarano, Qing Shi, Kenneth C. Ha, Primal de Lanerolle, and Audrey Minden. "Activated PAK4 Regulates Cell Adhesion and Anchorage-Independent Growth." Molecular and Cellular Biology 21, no. 10 (2001): 3523–33. http://dx.doi.org/10.1128/mcb.21.10.3523-3533.2001.

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ABSTRACT The serine/threonine kinase PAK4 is an effector molecule for the Rho GTPase Cdc42. PAK4 differs from other members of the PAK family in both sequence and function. Previously we have shown that an important function of this kinase is to mediate the induction of filopodia in response to activated Cdc42. Since previous characterization of PAK4 was carried out only with the wild-type kinase, we have generated a constitutively active mutant of the kinase to determine whether it has other functions. Expression of activated PAK4 in fibroblasts led to a transient induction of filopodia, whic
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Dissertations / Theses on the topic "Rho GTPases. Cells Fibroblasts"

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Debbio, Carolina Beltrame Del. "GTPases Rho e o potencial regenerativo da retina de mamíferos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-25032010-150345/.

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O Corpo Ciliar (CC) é uma fonte de células tronco da retina de animais adultos, mas sua ativação permanece desconhecida. GTPases Rho são proteínas que reorganizam do citoesqueleto de actina, regulam vias de sinalização e transcrição gênica, sobrevivência celular e proliferação. Neste trabalho, investigamos a expressão das GTPases Rho nas células do CC e seu efeito na regulação do ciclo celular. As GTPases RhoA, RhoB e Rac1 foram expressas nas células do CC e sua ativação pelo ácido lisofosfatidico (LPA) aumentou a expressão dos genes progenitores retinianos Pax6 e Chx10. A inibição das proteín
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Raftopoulou, Myrto. "Role of Rho GTPases and PTEN in the migration of human glioma cells." Thesis, University College London (University of London), 2003. http://discovery.ucl.ac.uk/1383221/.

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Rho GTPases play a key role in regulating the migration of many cell types including astrocytes. Astrocytcs are relatively poor migrating cells, whereas, gliomas, can be highly invasive, infiltrating the surrounding tissue and spreading difftisely in the brain due, in part, to their highly motile behaviour. This thesis investigates the aberrant migration of three human glioma cell lines (U373, U138, U87) and, using microinjection techniques, it is shown that the small GTPase Rac is essential for the migration of astrocytes as well as for the three glioma cell lines. In agreement with a higher
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Koh, Wonshill. "Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6045.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2008.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2008" Includes bibliographical references.
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Houy, Sébastien. "Sécrétion hormonale dans les cellules chromaffines saines et tumorales : régulation par les GTPases Rho." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ065.

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Les cellules neuroendocrines sécrètent hormones et neuropeptides dans la circulation sanguine par un processus d’exocytose régulée par le calcium. Engendrant un apport de membrane important à la surface cellulaire, l'exocytose doit être suivie par un processus d’endocytose compensatrice afin de maintenir l’homéostasie cellulaire et assurer le recyclage des composés vésiculaires. La connaissance précise des mécanismes moléculaires qui régulent la sécrétion neuroendocrine est primordiale. En effet, de nombreux cancers neuroendocrines sont associés à un dysfonctionnement de la sécrétion hormonale
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Calderon, Abram [Verfasser], Philippe I. [Akademischer Betreuer] Bastiaens, and Martin [Gutachter] Engelhard. "Acute perturbation and activity measurement of Rho GTPases in living cells / Abram Calderon. Betreuer: Philippe I. Bastiaens. Gutachter: Martin Engelhard." Dortmund : Universitätsbibliothek Dortmund, 2014. http://d-nb.info/1107053137/34.

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Piltti, Juha. "Responses of fibroblasts and chondrosarcoma cells to mechanical and chemical stimuli." Doctoral thesis, Umeå universitet, Institutionen för integrativ medicinsk biologi (IMB), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133851.

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Osteoarthritis is an inflammation-related disease that progressively destroys joint cartilage. This disease causes pain and stiffness of the joints, and at advanced stages, limitations to the movement or bending of injured joints. Therefore, it often restricts daily activities and the ability to work. Currently, there is no cure to prevent its progression, although certain damaged joints, such as fingers, knees and hips, can be treated with joint replacement surgeries. However, joint replacement surgeries of larger joints are very invasive operations and the joint replacements have a limited l
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Ando, Yoshikazu. "Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells." Kyoto University, 2008. http://hdl.handle.net/2433/135856.

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Reyes-Rodriguez, Angel L. "Dendritic Cells Enhance HIV Infection of Memory CD4+ T Cells in Human Lymphoid Tissues." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448463150.

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Franko, Jennifer Lynne. "Regulation of Effector/Memory T Cell Activation by Inducible Co-Stimulator (ICOS)." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1228358364.

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Ma, Shuang. "Preoptic Regulatory Factor 2 Inhibits Proliferation and Enhances Drug Induced Apoptosis in Neural Stem Cells." View abstract, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3353557.

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Book chapters on the topic "Rho GTPases. Cells Fibroblasts"

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Doye, Anne, Amel Mettouchi, and Emmanuel Lemichez. "Assessing Ubiquitylation of Rho GTPases in Mammalian Cells." In Methods in Molecular Biology. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-442-1_5.

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Gundersen, Gregg G., Ying Wen, Christina H. Eng, et al. "Regulation of Microtubules by Rho GTPases in Migrating Cells." In Signalling Networks in Cell Shape and Motility. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/047001766x.ch10.

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Cerutti, Camilla, and Anne J. Ridley. "Analyzing the Roles of Rho GTPases in Cancer Cell Adhesion to Endothelial Cells Under Flow Conditions." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1350-4_7.

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Nayak, Ramesh C., Kyung-Hee Chang, and Jose A. Cancelas. "Regulation of the Cytoskeleton by the Rho Family of GTPases in Hematopoietic Stem Cells in Health and Disease." In The Cytoskeleton in Health and Disease. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2904-7_3.

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Liu, Jian-Qin, and Katsunori Shimohara. "A Novel Programmable Molecular Computing Method Based on Signaling Pathways Regulated by Rho-GTPases in Living MDCK Epithelial Mammalian Cells." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-30217-9_32.

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Nobes, Catherine D. "Rho GTPases and cell migration-fibroblast wound healing." In Methods in Enzymology. Elsevier, 2000. http://dx.doi.org/10.1016/s0076-6879(00)25464-5.

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Zhang, Xuejing, and Daotai Nie. "Rho GTPases and Breast Cancer." In Breast Cancer - Focusing Tumor Microenvironment, Stem cells and Metastasis. InTech, 2011. http://dx.doi.org/10.5772/21703.

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S., Michael, and Michael F. "Rho-GTPases in Embryonic Stem Cells." In Embryonic Stem Cells - Basic Biology to Bioengineering. InTech, 2011. http://dx.doi.org/10.5772/22785.

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Wojciak‐Stothard, Beata, and James Leiper. "Rho GTPases and Hypoxia in Pulmonary Vascular Endothelial Cells." In Methods in Enzymology. Elsevier, 2008. http://dx.doi.org/10.1016/s0076-6879(07)00420-x.

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Denker, Sheryl P., Weihong Yan, and Diane L. Barber. "Effect of Rho GTPases on NaH exchanger in mammalian cells." In Methods in Enzymology. Elsevier, 2000. http://dx.doi.org/10.1016/s0076-6879(00)25455-4.

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Conference papers on the topic "Rho GTPases. Cells Fibroblasts"

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Klein, Richard M., and Paul J. Higgins. "Abstract 1434: Invasion of melanoma cells resistant to BRAF inhibition involves RHO-family GTPases." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1434.

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Na, Sungsoo. "Engineering Tools for Studying Coordination Between Biochemical and Biomechanical Activities in Cell Migration." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53709.

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Cell migration is achieved by the dynamic feedback interactions between traction forces generated by the cell and exerted onto the underlying extracellular matrix (ECM), and intracellular mechano-chemical signaling pathways, e.g., Rho GTPase (RhoA, Rac1, and Cdc42) activities [1,2,3]. These components are differentially distributed within a cell, and thus the coordination between tractions and mechanotransduction (i.e, RhoA and Rac1 activities) must be implemented at a precise spatial and temporal order to achieve optimized, directed cell migration [4,5]. Recent studies have shown that focal a
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Lazarini, Mariana, and Luciana Bueno De Paiva. "Prostate cancer cells are responsive to glucose and glutamine deprivation and ARHGAP21 has a promising role in the energetic metabolism through the regulation of Rho GTPases." In XXIII Congresso de Iniciação Científica da Unicamp. Galoá, 2015. http://dx.doi.org/10.19146/pibic-2015-38080.

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Steward, Robert L., Chao-Min Cheng, and Philip R. LeDuc. "Probing Dynamic Responses of the Extracellular Matrix to Coupled Mechanical and Chemical Inputs." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19206.

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The extracellular matrix (ECM) is an important cellular component that provides structural support for cells that form the various connective tissues in the body and has been linked to various important cellular processes. One major, ubiquitously expressed ECM protein, fibronectin (FN) has been well documented to play an important role in the ECM, but most studies have investigated FN and its assembly and structural organization mainly through chemical stimulation. The ECM though likely experiences multiple modes of stimulation such as mechanical and chemical inputs. Since cells and the ECM ma
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