Relevant bibliographies by topics / Ribofuranosyl

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Ribofuranosyl'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Ribofuranosyl"

1

Hanaya, Tadashi, Kiyoshi Torigoe, Kazuyuki Soranaka, Hiroshi Fujita, Wolfgang Pfleiderer та Hiroshi Yamamoto. "An Efficient Synthesis of 2'-O-(β-D-Ribofuranosyl)biopterin". Pteridines 19, № 1 (2008): 72–78. http://dx.doi.org/10.1515/pteridines.2008.19.1.72.

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AbstractN2-(N,N-Dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]-1',2'-di-O-(trimethylsilyl)biopterin (4) was prepared from biopterin (1a, 86% overall yield) in 5 steps. Glycosylation of 4 with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose (5a) and its 2,3,5-tri-O-benzoyl analog (5b) respectively afforded the corresponding 2'-O-(2,3,5-tri-Oacetyl- and 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)biopterin derivatives (6a, 42% and 6b, 60%) as major products. Removal of the protecting groups of 6b provided 2'-O-(β-D-ribofuranosyl)biopterin (1c, 87% overall yield) in 3 steps.
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2

Spassova, Maria K., Antonín Holý, and Milena Masojídková. "Ribonucleosides of 3-amino- and 3,5-diaminopyrazole-4-carboxylic acid and their open-chain analogues: Synthesis and reactions." Collection of Czechoslovak Chemical Communications 51, no. 7 (1986): 1512–31. http://dx.doi.org/10.1135/cccc19861512.

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Bis(trimethylsilyl) derivative of ethyl 3-aminopyrazole-4-carboxylate (VI) and tris(trimethylsilyl) derivative of ethyl 3,5-diaminopyrazole-4-carboxylate (VII) on reaction with 2,3,5-tri-O-benzoyl-D-ribofuranolyl chloride and subsequent debenzoylation afforded the respective β-D-ribofuranosyl derivatives VIIIa and Xa. Their alkaline hydrolysis led to 1-(β-D-ribofuranosyl)-3-aminopyrazole-4-carboxylic acid (VIIIc) and 1-(β-D-ribofuranosyl)-3,5-diaminopyrazole-4-carboxylic acid (Xb). The esters VIIIa and Xa were not ammonolyzed under normal conditions. Contrary to nucleosidation of the silyl der
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3

Tiwari, Sangeeta, Ashok K. Yadav, and A. K. Mishra. "Some New Pyrido[2,3-d]pyridimines and their Nucleoside of Biological Importance." E-Journal of Chemistry 7, s1 (2010): S85—S92. http://dx.doi.org/10.1155/2010/812567.

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Chalcones (I) reacted with malanonitrile and ammonium acetate yielded 2-amino-3-cyano-4,6-disubstituted pyridines (II) in excellent yield. 4-Amino-5,7-disubstituted pyrido [2,3-d]pyrimidine-2(1H)-thiones (III), 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines (IV) and 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-2(1H)-ones (V) have been synthesized by the condensation of compound (II) with thiourea, formamide and arylisocynate respectively. The ribofuranosidesviz. 4-amino-5,7-disubstituted-1- [2',3',5'-tri-o-benzoyl-β,D-ribofuranosyl]pyrido[2,3-d]pyrimidine-2-(1H)-thiones (VI) and 4-i
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4

Luo, Yan, та David L. Zechel. "A concise synthesis of α-D-ribofuranosyl alkylphosphonates — Putative substrate intermediates for the carbon–phosphorous lyase system". Canadian Journal of Chemistry 84, № 4 (2006): 743–47. http://dx.doi.org/10.1139/v06-038.

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Carbon–phosphorous lyase is a multienzyme system found in many species of bacteria that is distinguished by its ability to hydrolyze a broad array of unactivated alkylphosphonates. α-D-Ribofuranosyl alkylphosphonates are potential metabolic intermediates generated by the carbon–phosphorous lyase pathway. Here we describe a facile synthesis of α-D-ribofuranosyl alkylphosphonates using β-D-ribofuranosyl trichloracetimidate as a glycosyl donor.Key words: carbon–phosphorous lyase, phn operon, phnN, phosphonates, glycosyl trichloroacetimidate donor, α-D-ribofuranosyl ethylphosphonate.
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Otmar, Miroslav, Ivan Rosenberg, Milena Masojídková, and Antonín Holý. "[5-(Adenin-9-yl)-5-deoxy-L-pentofuranosyl]phosphonates - A Novel Type of Nucleotide Analogs Related to HPMPA. II. Synthesis of L-ribo and L-xylo Configurated Derivatives by Recyclization of Diethyl (5-RS)-[1,2-O-Isopropylidene-5-O-methanesulfonyl-D-pentofuranos-5-C-yl]phosphonates under Acidic Conditions." Collection of Czechoslovak Chemical Communications 58, no. 9 (1993): 2180–96. http://dx.doi.org/10.1135/cccc19932180.

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Further cyclic analogs of the antiviral (S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine (I) were prepared: both anomers of [5-(adenin-9-yl)-5-doxy-L-ribofuranosyl]phosphonic acid (α-IId and β-IId) and [5-(adenin-9-yl)-5-doxy-α-L-ribofuranosyl]phosphonic acid (IIe). Recyclization reaction of diethyl (5RS-(3-O-benzyl-1,2-O-isopropylidene-5-O-methanesulfonyl-D-ribofuranos-5-C-yl)phosphonate (IVb) and diethyl (5RS-(3-O-benzyl-1,2-O-isopropylidene-5-O-methanesulfonyl-D-xylofuranos-5-C-yl)phosphonate (IVd) in trifluoroacetic acid led to cyclic aldehydes Va and Vb which were reduced to diethyl α- a
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Nauš, Petr, Martin Kuchař, and Michal Hocek. "Cytostatic and Antiviral 6-Arylpurine Ribonucleosides IX. Synthesis and Evaluation of 6-Substituted 3-Deazapurine Ribonucleosides." Collection of Czechoslovak Chemical Communications 73, no. 5 (2008): 665–78. http://dx.doi.org/10.1135/cccc20080665.

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A series of 3-deazapurine ribonucleosides 5a-5l bearing diverse C-substituents (alkyl, aryl and heteroaryl) in the position 6 were prepared by Pd-catalyzed cross-coupling reactions of either free 6-chloro-3-deazapurine ribonucleoside 4 or its acetyl protected congener 3 followed by deprotection. An improved synthesis of the starting 4-chloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridine (3) was developed by the application of Vorbrüggen glycosylation of silylated nucleobase with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose (2). None of compounds 5a-5l showed any considerable cy
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Tatarinov, Dmitry A., Bulat F. Garifullin, Mayya G. Belenok, et al. "The First 5′-Phosphorylated 1,2,3-Triazolyl Nucleoside Analogues with Uracil and Quinazoline-2,4-Dione Moieties: A Synthesis and Antiviral Evaluation." Molecules 27, no. 19 (2022): 6214. http://dx.doi.org/10.3390/molecules27196214.

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A series of 5′-phosphorylated (dialkyl phosphates, diaryl phosphates, phosphoramidates, H-phosphonates, phosphates) 1,2,3-triazolyl nucleoside analogues in which the 1,2,3-triazole-4-yl-β-D-ribofuranose fragment is attached via a methylene group or a butylene chain to the N-1 atom of the heterocycle moiety (uracil or quinazoline-2,4-dione) was synthesized. All compounds were evaluated for antiviral activity against influenza virus A/PR/8/34/(H1N1). Antiviral assays revealed three compounds, 13b, 14b, and 17a, which showed moderate activity against influenza virus A (H1N1) with IC50 values of 1
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Break, Laila Mohammed, та Wafa Saad Al-harthi. "Synthesis New of Nucleoside of 1,3-bis-(2,3,5-tri-O-Benzoyl-β-D-Ribofuranosyl)-8-(Trifluoromethyl)-2-Methyl-4-Quinazolinone". Proceedings 9, № 1 (2018): 57. http://dx.doi.org/10.3390/ecsoc-22-05694.

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Fluorinated nucleosides are very important for increased biological and chemical stability of organ fluorine compounds. Synthesis of (1H)-8-trifluloromethyl-2-methyl-4-quinazolinone 3 from 2-amino-3-(trifluoromethyl) benzoic acid 1 was performed. Ribosylation of compound 4 with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-d-ribofuranose 5 using the silylation method created the benzoylated nucleoside derivative 6. Debenzoylation of the protected nucleoside 6 via reaction with sodium metal in dry methanol to create the corresponding free nucleoside 1,3-bis-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-8-(trifluo
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Guglielmi, Hans, Markus Dachtler, and Klaus Albert. "Imidazole Nucleosides, V. Synthesis of 3′-Fluoro-3′-deoxy-ribofuranosides of 4(5)-Amino-imidazoIe-5(4)carboxamide." Zeitschrift für Naturforschung B 54, no. 8 (1999): 1055–60. http://dx.doi.org/10.1515/znb-1999-0814.

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The synthesis of the 3′-fluoro-derivatives of 5-amino-1-(β-D-ribofuranosyl)imidazole-4- carboxamide (AICA-riboside) and the isomeric 4-amino-1(β-D-ribofuranosyl)imidazole-5- carboxamide (iso-AICA-riboside) are described. Structures were confirmed by elemental analysis, UV and 1H NMR spectroscopy. The anti-viral and anti-cancer activities of these imidazole nucleosides were tested.
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Andreeva, Olga V., Bulat F. Garifullin, Vladimir V. Zarubaev, et al. "Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues." Molecules 26, no. 12 (2021): 3678. http://dx.doi.org/10.3390/molecules26123678.

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A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragments are attached via polymethylene linkers to both nitrogen atoms of the heterocycle moiety (uracil, 6-methyluracil, thymine, quinazoline-2,4-dione, alloxazine) or to the C-5 and N-3 atoms of the 6-methyluracil moiety was synthesized. All compounds synthesized were evaluated for antiviral activity against influenza virus A/PR/8/34/(H1N1) and coxsackievirus B3. Antiviral assays revealed three compounds, 2i, 5i, 11c, which showed moderate activity against influenza virus A H1N1 with IC50 values o
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Dissertations / Theses on the topic "Ribofuranosyl"

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Alzwiy, Ibrahim A. Mohamed. "The interaction between abiotic and biotic stress in Arabidopsis thaliana." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/13946.

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Plants are continuously exposed to different abiotic and biotic stresses in their natural environment. Their capacity to survive depends on the capacity to perceive external signal and quality amount a defence response for protection from the stress perceived. The purpose of this project was to study the impact of combined abiotic stress and biotic stress on the outcome of the disease inducing Arabidopsis thaliana – Pseudomonas syringae interaction. This study included a focus on the role of ABA in these interactions and also whether 3´-O-β D- ribofuranosyl adenosine (hereafter it called ‘400’
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2

Pochet, Sylvie. "Synthèse d'oligodésoxynucléotides comportant des sites ambigus ou apuriniques et de sondes ancrées à un support solide." Paris 6, 1986. http://www.theses.fr/1986PA066065.

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Synthèse et étude par spectroscopies RMN, IR et DC d'oligodésoxyribonucléotides contenant un résidu sans base: coexistence des conformations b et z sur un même duplex. Elaboration d'une base universelle dans la série des nucléosides pyrimidiques. Synthèse d'oligodésoxynucléotides ancrés à un support solide; applications.
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Le, Hir de Fallois Loic. "Synthèse et étude de nucléosides et nucléotides inhibiteurs de la ribonucléotide réductase." Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE10158.

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La ribonucleotide reductase (rnr) est l'enzyme qui catalyse la reduction des ribonucleotides en desoxyribonucleotides. En raison de son role fondamental dans la synthese de l'adn, cette enzyme est une cible cle de la recherche de nouveaux agents antitumoraux. Dans le but d'inhiber cette enzyme nous avons synthetise des analogues de substrats. Nous avons synthetise et etudie les proprietes des premiers nucleosides thionitrites, les 2'-desoxy-2'-s-nitroso-uridine et -cytidine. Nous avons demontre que ces thionitrites liberent du monoxyde d'azote (no) qui est un inhibiteur de la ribonucleotide re
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4

Lespinasse, Anne-Dominique. "Voies d’accès à des dérives aminés du D-fructofuranose et du D-psicofuranose." Lyon, INSA, 1985. http://www.theses.fr/1985ISAL0057.

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Nos travaux s'inscrivent dans le domaine de la chimie des cétohexoses et en particulier de deux d'entre eux : le D-fructose et le D-psicose. En vue de l'évaluation des potentialités biologiques de ces oses, nous avons d'abord étudié les voies'd'accès à des nucléosides dérivés du D-fructofuranose puis la synthèse de composés aminés issus de cet ose et du D-psicofuranose. Cette approche nous a amené à mettre au point la préparation d'un dérivé du D-psicofuranose comportant une différenciation au niveau de ses deux hydroxyméthyles. Ce composé devrait permettre de résoudre certains problèmes synth
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Liang-kuen, Huang, and 黃亮焜. "Synthesis and application of D-ribofuranosyl derivative." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/40020785785097495889.

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Books on the topic "Ribofuranosyl"

1

Horlacher, Jenny. Enzymatic incorporation of non-standard base pairs into DNA: 2'-deoxynucleotides of 2,4-diamino-5-([beta]-D-ribofuranosyl)-pyrimidine (kappa), 1-methyloxoformycin B (pi) and xanthosine (chi) as substrates for DNA polymerases. 1995.

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2

Hammer, Christophe L. Synthesis and studies towards DNA incorporation of the base pair PyDDA-PuAAD: Synthesis and studies towards the DNA incorporation of a carbocyclic 2'-O-methylated analogue to 6-amino-3-[(Beta)-D-ribofuranosyl]-5-methyl-pyrazine-2-one. Synthesis and DNA incorporation of 2'deoxy-5-aza-3, 7-denza-guanosine. 1997.

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Book chapters on the topic "Ribofuranosyl"

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Guinan, M., G. J. Miller, D. Lynch, and M. Smith. "Synthesis of 1′-(4′-Thio-β-d-Ribofuranosyl) Uracil." In Carbohydrate Chemistry. CRC Press, 2021. http://dx.doi.org/10.1201/9781351256087-28.

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Natarajan, Ettaya, and Charles B. Grissom. "Insight Into the Mechanism of B12Dependent Enzymes: Magnetic Field Effects as a Probe of Reaction Mechanism and the Role of the Ribofuranose Ring Oxygen." In Vitamin B12and B12-Proteins. Wiley-VCH Verlag GmbH, 2007. http://dx.doi.org/10.1002/9783527612192.ch26.

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"Nebularine (9-β-d-ribofuranosyl-9H-purine)." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_11217.

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Briant, C. E., D. W. Jones, and J. D. Shaw. "Structure and stereochemistry of some ribofuranosyl nucleosides and related imidazole compounds." In Correlations, transformations, and interactions in organic crystal chemistry. Oxford University PressOxford, 1994. http://dx.doi.org/10.1093/oso/9780198558262.003.0016.

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Abstract Among the many nucleoside and nucleotide crystal structures that have been reported, rather few involve the five-membered imidazole ring (which has similarities with the five-membered ring in the common purines adenine, guanosine and inosine). Some of the 2,3-O-isopropylidene Nglycosylimidazole nucleosides synthesized by Professor G. Shaw and colleagues (Cusack et al., 1973; Mackenzie et al., 1976) are related to active intermediates in the de novo biosynthesis of nucleotides and to biologically active naturally occurring nucleosides, generally as β anomer.
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Wächtler, Heike, Dilver Peña Fuentes, Olena Apelt, Christian Vogel, Dirk Michalik, and Mykhaylo A. Potopnyk. "Improved Synthesis of 3-(β-d-Ribofuranos-1-yl) prop-1-ene." In Carbohydrate Chemistry. CRC Press, 2017. http://dx.doi.org/10.1201/9781315120300-34.

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Hirota, Kosaku, Yasunari Monguchi, and Hironao Sajki. "Synthesis of Purine Acyclonucleosides via Ribofuranose-Ring Cleavage of Purine Nucleosides by Diisobutylaluminum Hydride." In Recent Advances in Nucleosides: Chemistry and Chemotherapy. Elsevier, 2002. http://dx.doi.org/10.1016/b978-044450951-2/50003-5.

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Conference papers on the topic "Ribofuranosyl"

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Smirnova, O. S., and I. D. Konstantinova. "CHEMO-ENZYMATIC SYNTHESIS OF NEW RIBAVIRIN ANALOGS." In OpenBio-2023. ИПЦ НГУ, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-51.

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Smirnova, O. S., and I. D. Konstantinova. "BIOTECHNOLOGICAL SYNTHESIS THE ANTIVIRAL DRUG RIBAVIRIN ANALOGUES MODIFIED ON THE AMIDE GROUP." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-47.

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Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a well-known antiviral nucleoside. It has attracted interest for more than 40 years due to its unique spectrum of activity and still unclear mechanism of action. However, ribavirin has a high systemic toxicity and teratogenicity. Therefore, the search for new analogs of ribavirin with lower toxicity and high antiviral activity is still relevant.
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Chun, B. K., J. L. Clark, J. Du та ін. "5',9-Anhydro-3-(β-D-ribofuranosyl)purine nucleoside analogues as potential anti-HCV agents". У XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507319.

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Mikhailov, Sergey N., Ekaterina V. Efimtseva, Alexandra A. Shelkunova та ін. "Chemical incorporation of minor tRNA component O-β-D-ribofuranosyl-(1''-2')-adenosine-5''-phosphate into oligoribonucleotides". У XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507333.

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Hosmane, Ramachandra, та Huan-Ming Chen. "Synthesis of 1-(2'-Deoxy-γ-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5 H,6H)-dion: a Potentially Beneficial Building Block for Antisense Applications". У The 4th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01926.

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Golovan, Anna, Kristina Naumenko, Galina Baranova, and Svitlana Zagorodnya. "Study of the antiviral activity of the nucleoside analogue 2-(beta-D-ribofuranosyl)-5-amino-1,2,4-triazine-3(2H)-one against Epstein-Barr virus." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a039.

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Hosmane, Ramachandra, та Huan-Ming Chen. "Synthesis of 1-(2'-O-Methyl-γ -D-Ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dion: an Attractive Building Block for Antisense and Triple-helical Applications". У The 4th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01925.

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Mikhailopulo, Igor A., та Grigorii G. Sivets. "Synthesis of peracylated derivatives of L-ribofuranose from D-ribose and their use for the preparation of β-L-ribonucleosides". У XIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902053.

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