Relevant bibliographies by topics / Ribosomas

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Academic literature on the topic 'Ribosomas'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Dissertations / Theses on the topic "Ribosomas"

1

Rivero, Jiménez Matías Alberto. "Estudio del mecanismo de inicio de la traducción del mensajero completo del virus de la inmunodeficiencia humana de tipo 1 : caracterización de un modelo de iniciación dual." Tesis, Universidad de Chile, 2011. http://repositorio.uchile.cl/handle/2250/105392.

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En organismos eucariontes, el inicio de la síntesis de proteínas comienza con el reclutamiento de la subunidad 40S del ribosoma al mRNA. Sin embargo, dependiendo de cómo se efectúe este reclutamiento, el inicio de la traducción puede ser dependiente o independiente de la estructura 5’cap. El mecanismo cap-dependiente se basa en el reconocimiento de la estructura cap (7mGpppN), presente en el extremo 5’ de todos los mRNA, por el complejo de iniciación eIF4F. El complejo eIF4F está constituido por tres proteínas: eIF4E, la proteína de unión al cap; eIF4A, una RNA helicasa ATP dependiente
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2

Morcelle, Magaña Carmen. "The role of the RPL5/RPL11/5S rRNA complex in mediating p53 levels in response to c-Myc depletion in colorectal carcinoma." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/457876.

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In most human cancers, the c-Myc transcription factor is deregulated and/or its levels are elevated, particularly in colorectal cancer (CRC). Earlier studies suggested a direct relationship between ribosome biogenesis and c-Myc-induced tumorigenesis, with recent reports arguing that ribosomal proteins L5 (RPL5) and RPL11 act against c- Myc-driven tumorigenesis as tumor suppressors by inhibiting MDM2 and inducing p53 stabilization. Our laboratory recently showed that upon inhibition of ribosome biogenesis, a nascent pre-ribosomal complex containing RPL5, RPL11 and 5S rRNA is redirected from 60S
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3

Meza, Soto Stfanny Wendy. "Estudio preliminar de la interacción entre la proteína del síndrome de Werner, presente en la fracción citoplasmática de células HeLa, y la proteína ribosomal humana S3 recombinante mediante el ensayo in vitro de pull-down." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2018. https://hdl.handle.net/20.500.12672/8314.

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Publicación a texto completo no autorizada por el autor<br>El gen WRN codifica a la proteína del síndrome de Werner (WRN), una proteína multifuncional con actividad helicasa y exonucleasa. Datos previos indican que WRN está asociada a la maquinaria traduccional y relacionada con las vías metabólicas que regulan la síntesis de macromoléculas, la producción de energía y el balance de óxidoreducción (redox) implicados en la proliferación celular. La proteína ribosomal eucariota S3 (eRPS3) es un elemento importante de la subunidad ribosomal menor 40S que promueve el reconocimiento del codón de ini
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4

Adriano, Escobar Gina Jackelinne. "Caracterización molecular de bacterias celulolíticas aisladas de ambientes salinos del Perú." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2012. https://hdl.handle.net/20.500.12672/12154.

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Identifica las bacterias celulolíticas productoras de celulasas extracelulares aisladas de ambientes salinos de Perú. Para ello, se utilizaron 140 aislados, 25 de Maras (Cusco), 28 de Chilca (Lima), 42 de Pilluana (San Martín), 25 de San Blas (Junín) y 20 de la bahía de Paracas (Ica), todos fueron sembrados en agar carboximeti lcelulosa 1 % (p/v) suplementado con extracto de levadura 0,5 % y agua de sales 5%, se incubaron a 37 °C durante 48 h, luego se añadió a las placas solución rojo de congo 1 % (p/v) como agente revelador. Se seleccionaron 20 bacterias con actividad celulolítica, que se c
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5

Gallo, López Carolina 1984. "Determinants of growth rate in genome-reduced bacteria." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/664510.

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Understanding how the growth rate is regulated in bacteria is an ongoing challenge in biology and its controlled regulation would have a great impact in the biotechnological industry. Growth rates may be regulated by several genetic factors, but despite some of them are known, we are still unable to rationally increase bacterial growth rates. Most studies are done in fast-growing and highly complex bacteria with large and redundant genomes. Mycoplasma pneumoniae, from the Mollicutes class, is a simpler organism with one of the smallest genomes. Furthermore, Mollicutes species have wide range o
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6

Domostegui, Fernández Ana. "IRBC-induced p53-dependent Cell Death in c-MYC-driven tumors mediated by loss of MCL1." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668147.

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The oncogene MYC is altered and its expression is deregulated in up to 70% of human cancers, including B cell neoplasms. Earlier studies in a mouse model of Eμ-MYC-driven B-cell lymphomas reported that oncogenic MYC relies on aberrant rates of ribosome biogenesis (RiBi) and protein synthesis to sustain rapid growth and proliferation of B-cell lymphomas. As MYC driven B-cell lymphomas are addicted to hyperactivation of RiBi, it has emerged as a potential clinical target. However, it is unclear whether targeting RiBi induces regression of MYC-driven tumors by decreasing translational capacity an
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7

Shimmin, Lawrence Charles. "An archaebacterial ribosomal protein gene cluster." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30994.

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The eubacteria, archaebacteria and eucaryota evolved from a common ancestral state, the progenote, approximately 4,000 million years ago. The archaebacteria flourish in extreme environments, exhibiting unusual macromolecular structures and metabolism of which much has recently been elucidated. Less, however, is known of the genetics of archaebacteria. In order to investigate gene structure, organization, regulation and evolution in the archaebacteria a gene cluster encoding the ribosomal proteins of the GTPase domain was cloned from the extremely halophilic archaebacterium Halobacterium cutiru
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8

Dator, Romel P. "Characterization of Ribosomes and Ribosome Assembly Complexes by Mass Spectrometry." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1382373082.

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9

Roy, Poorna. "Deconstructing the ribosome: specific interactions of a ribosomal RNA fragment with intact and fragmented L23 ribosomal protein." Thesis, Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47579.

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The complexity of translation is a classical dilemma in the evolution of biological systems. Efficient translation requires coordination of complex, highly evolved RNAs and proteins; however, complex, highly evolved RNAs and proteins could not evolve without efficient translation system. At the heart of this complexity is the ribosome, itself a remarkably complex molecular machine. Our work illustrates the ribosome as deconstructed units of modification. Here we have deconstructed a segment of the ribosome to interacting RNA-protein units. L23 interacts in vivo with both Domain III (DIII)
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10

Riaño, Canalias Ferran. "The effect of inhibition of nucleotide synthesis on ribosome biogenesis and the induction of p53." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/457972.

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Ribosome biogenesis is one of the most energy consuming anabolic processes in a cell, required for the generation of the translational machinery to grow and proliferate. Moreover, this process necessitates the coordination of protein and nucleotide synthesis to generate ribosomal proteins (RPs) and ribosomal RNA (rRNA). Critically, increased rates of ribosome biogenesis are a hallmark of c-Myc driven CRC required to sustain exacerbated growth and proliferation, with recent studies showing that drugs that target ribosome biogenesis are clinically efficacious. We have previously shown that upon
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