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1

Tarasevich, Irina Vladimirovna. Astrakhanskai͡a︡ pi͡a︡tnistai͡a︡ likhoradka. "Medit͡s︡ina", 2002.

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2

E, Hechemy Karim, and New York Academy of Sciences, eds. Century of rickettsiology: Emerging, reemerging rickettsioses, molecular diagnostics, and emerging veterinary rickettsioses. Blackwell Pub. on behalf of the New York Academy of Sciences, 2006.

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3

J, Schmidt Nathalie, and Emmons Richard W, eds. Diagnostic procedures for viral, rickettsial, and chlamydial infections. 6th ed. American Public Health Association, 1989.

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4

Burt, Anderson, Friedman Herman 1931-, and Bendinelli Mauro, eds. Rickettsial infection and immunity. Plenum Press, 1997.

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5

Ming, Tan, Guy Palmer, and Abdu F. Azad. Intracellular pathogens II: Rickettsiales. ASM Press, 2012.

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6

Anderson, Burt, Herman Friedman, and Mauro Bendinelli, eds. Rickettsial Infection and Immunity. Kluwer Academic Publishers, 2002. http://dx.doi.org/10.1007/b111094.

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7

E, Hechemy Karim, and American Society for Rickettsiology and Rickettsial Diseases. Meeting, eds. Rickettsiology: Current issues and perspectives. New York Academy of Sciences, 1990.

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8

J, Schmidt Nathalie, and Emmons Richard W, eds. Diagnostic procedures for viral, rickettsial, and chlamydial infections. 7th ed. American Public Health Association, 1995.

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9

Evermann, James F. Laboratory diagnosis of zoonotic infections: Viral, rickettsial, and parasitic agents obtained from food animals and wildlife. Edited by Garcia Lynne Shore, Stone Diana M, and Inzana Thomas J. American Society for Microbiology, 1999.

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10

Fletcher, Tom, and Nick Beeching. Rickettsial infection. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0314.

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Rickettsial infections are caused by a variety of obligate intracellular, Gram-negative bacteria from the genera Rickettsia, Orientia, Ehrlichia, and Anaplasma. Rickettsia is further subdivided into the spotted fever group and the typhus group. Bartonella and Coxiella burnetii bacteria are similar to rickettsiae and cause similar diseases. The range of recognized spotted fever group infections is rapidly expanding, complementing long-recognized examples such as Rocky Mountain spotted fever (Rickettsia rickettsii) in the US, and Australian tick typhus (Rickettsia australis), as well as those in southern Europe and Africa. Animals are the predominant reservoir of infection, and transmission to people is usually through ticks, mites, fleas, or lice, during blood-feeding or from scarification of faeces deposited on the skin. This chapter focuses on the two of the most relevant infections encountered in UK practice: African tick typhus, and Q fever.
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11

Tuddenham, Susan. Ehrlichia, Anaplasma, and Rickettsia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0051.

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Rickettsia, Ehrlichia, and Anaplasma are infections primarily transmitted by ticks (but, in the case of certain Rickettsial species, are transmitted by other vectors as well), which can cause an abrupt, febrile, and flu-like illness often associated with headache, nausea, vomiting, abdominal pain, rash, elevated liver function tests, and thrombocytopenia. Disease can be severe, particularly when patients are infected with Rickettsia rickettsii (Rocky Mountain Spotted Fever); patients may develop central nervous system involvement, shock, and multiorgan failure. Diagnostic tests are imperfect, and prompt empiric treatment should be initiated if disease is suspected. Doxycycline is the treatment of choice, and coinfection with other vector-borne pathogens may need to be considered.
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12

Rickettsiology And Rickettsial Diseases Fifth International Conference. Wiley-Blackwell, 2009.

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13

Matthews, Philippa C. Infections caused by obligate intracellular bacteria. Edited by Philippa C. Matthews. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198737773.003.0006.

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This chapter consists of short notes, diagrams, and tables to summarize infections caused by obligate intracellular bacteria. The chapter begins with a classification system to divide these organisms into Rickettsia, Anaplasma, Chlamydia, Coxiella, and Bartonella species. Separate sections then follow on the infections of most clinical significance for the tropics and subtropics, including the typhus group (caused by rickettsial infection) and Q fever. For ease of reference, each topic is broken down into sections, including classification, epidemiology, microbiology, pathophysiology, clinical syndromes, diagnosis, treatment, and prevention.
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14

Blanco, José R., Jose A. Oteo, Didier Raoult, and David J. Silverman. Rickettsioses: From Genome to Proteome, Pathobiology, and Rickettsiae as an International Threat (Annals of the New York Academy of Sciences). Blackwell Publishing Limited, 2005.

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15

Hechemy, Karim E., Spain) International Conference on Rickettsiae and Rickettsial Diseases (4th : 2005 : Logrono, and International Conference on Rickettsiae. Rickettsioses: From Genome to Proteome, Pathobiology, And Rickettsiae As an International Threat (Annals of the New York Academy of Sciences). New York Academy of Sciences, 2006.

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16

Cuttle, Lisa. Dermatologic Manifestations of Infectious Disease. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0044.

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Toxic infectious exfoliative conditions include staphylococcal toxic shock syndrome (TSS), streptococcal toxic shock syndrome (STSS), and staphylococcal scalded skin syndrome (SSSS). All three are mediated by bacterial toxin production and are considerations in the differential diagnosis of a febrile, hypotensive patient with a rash. Meningococcemia is potentially fatal and extremely contagious with a short incubation period. Disseminated gonococcal infection (DGI) presents with tenosynovitis, dermatitis, and polyarthralgias without purulent arthritis or with purulent arthritis but without skin lesions. Ecthyma gangrenosum (EG) is a cutaneous manifestation of Pseudomonas aeruginosa infection. Rocky Mountain Spotted Fever (RMSF) is caused by Rickettsia rickettsii, most commonly transmitted by the American dog tick. Patients present with nonspecific symptoms, such as fever, headache, myalgias, arthralgias, nausea, vomiting, and abdominal pain. Finally, vibrio vulnificus is a gram-negative bacterium that causes serious wound infections, sepsis, and diarrhea in patients exposed to shellfish or marine water.
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17

Burdmann, Emmanuel A., and Vivekanad Jha. Rickettsiosis. Edited by Vivekanand Jha. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0193.

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Rickettsiae are obligate intracellular bacteria transmitted by arthropods to a vertebrate host. Clinically relevant rickettsioses have a similar clinical pattern, manifesting as an acute febrile disease accompanied by headache, articular and muscle pain, and malaise.Epidemic typhus is a worldwide distributed disease caused by the Rickettsia prowazekii, with a human louse as a vector. Data on epidemic typhus-related renal injury is extremely scarce.Murine typhus is caused by the Rickettsia typhi and has a rodent flea as the vector. It is one of the most frequent rickettsioses, and is usually a self-limited febrile illness. Proteinuria, haematuria, elevations in serum creatinine (SCr) and/or blood urea nitrogen (BUN) and AKI have been reported. The real frequency of renal involvement in murine typhus is unknown. Renal abnormalities recover after the infectious disease resolution.Scrub typhus, caused by the Orientia tsutsugamushi, has the Leptotrombidium mite larva as vector. It is endemic in the Tsutsugamushi triangle delimited by Japan, Australia, India, and Siberia. It can manifest either as a self-limiting disease or as a severe, life-threatening multiorgan illness. Early administration of adequate antibiotics is essential to prevent adverse outcomes. Proteinuria, haematuria, and acute kidney injury (AKI) are frequent.Tick-borne rickettsioses are caused by bacteria from the spotted fever group and have ticks as vectors. Rocky Mountain spotted fever (RMSF) is caused by Rickettsia rickettsii. It is the most severe of the spotted fever rickettsial diseases, causing significant morbidity and lethality. RMSF occurs in North, Central, and South America. Renal impairment is frequent in severe forms of RMSF. Mediterranean spotted fever is caused by Rickettsia conorii, and is endemic in the Mediterranean area. It is usually a benign disease, but may have a severe course, clinically similar to RMSF. Haematuria, proteinuria, increased serum creatinine, and AKI may occur. Japanese spotted fever is caused by Rickettsia japonica. Lethal cases are reported yearly and AKI has occurred in the context of multiple organ failure.
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18

Jolly, Elaine, Andrew Fry, and Afzal Chaudhry, eds. Infectious diseases. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199230457.003.0012.

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Chapter 12 covers the basic science and clinical topics relating to infectious disease which trainees are required to learn as part of their basic training and demonstrate in the MRCP. It begins with an overview, before covering diagnostic techniques, sepsis, antibiotics, needlestick injury, nosocomial infection, travel-related infection, immunocompromised hosts, pyrexia of unknown origin, infection in injecting drug users, bioterrorism, viral infection, HIV and AIDS, bacterial infections, mycobacterial infections, rickettsial infections, systemic fungal infections, protozoal infections, and helminthic infections.
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19

Kohn, A. Immunity in Viral and Rickettsial Diseases: Proceedings of the Seventeenth Annual “OHOLO” Biological Conference on New Concepts in Immunity in Viral ... in Experimental Medicine and Biology). Springer, 2012.

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20

Kohn, A. Immunity in Viral and Rickettsial Diseases: Proceedings of the Seventeenth Annual OHOLO Biological Conference on New Concepts in Immunity in Viral and Rickettsial Diseases Held March 13-16, 1972, at Zichron Yaakov, Israel. Springer London, Limited, 2012.

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21

Azad, Abdu F., and Guy H. Palmer. Intracellular Pathogens II: Rickettsiales. Wiley & Sons, Limited, John, 2014.

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22

Friedman, Herman, Mauro Bendinelli, and Burt Anderson. Rickettsial Infection and Immunity. Springer London, Limited, 2006.

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23

Anderson, Burt. Rickettsial Infection and Immunity. Springer, 2013.

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24

York, C. J., and A. O. Betts. Viral and Rickettsial Infections of Animals. Elsevier Science & Technology Books, 2013.

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25

Lydyard, Peter, Michael Cole, John Holton, et al. Case Studies in Infectious Disease: Rickettsia spp. Garland Science, 2009. http://dx.doi.org/10.4324/9780203854020.

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26

(Editor), Didier Raoult, and Philippe Parola (Editor), eds. Rickettsial Diseases (Infectious Disease and Therapy). Informa Healthcare, 2007.

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27

Walker, David H., Karim E. Hechemy, David Paretsky, and Louis Mallavia. Rickettsiology: Current Issues and Perspectives (Annals of the New York Academy of Sciences, Vol 590). New York Academy of Sciences, 1990.

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28

Verma, Anita. Bacterial, fungal, and parasitic infections of the liver. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198759928.003.0065.

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The chapter on infections of the liver focuses on bacterial, fungal, and parasitic infections that may affect the organ. It includes liver abscess, cholangitis, spirochaetal, rickettsial, and fungal infections.
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29

Lennette, Edwin H., and P. Halonen. Laboratory Diagnosis of Infectious Diseases: Principles and Practice : Viral, Rickettsial, and Chlamydial Diseases (Laboratory Diagnosis of Infectious Diseases). Springer, 1988.

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30

(Editor), Burt Anderson, Herman Friedman (Editor), and Mauro Bendinelli (Editor), eds. Microorganisms and Bioterrorism (Infectious Agents and Pathogenesis). Springer, 2006.

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31

Angelakis, Emmanouil, and Didier Raoult. Scrub typhus. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0013.

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Bacteria of the genus Rickettsia are obligate intracellular rods that retained basic fuchsin when stained by the method of Gimenez. This genus has long been used as a generic term of small intracellular bacteria. However, taxonomic progress made over the last years has deeply modified the definition of “rickettsia”. As a result, in 1995 the position of R. tsutsugamushi has reclassified from the genus Rickettsia into a separate new genus, Orientia (Tamura et al. 1995).Scrub typhus, also known as ‘tsutsugamushi fever’, occurs only in Asia and is a chigger-borne zoonosis. The disease is acute, febrile, potentially fatal and has been known for centuries in China where it was probably described as early as in the fourth century BC (Parola and Raoult 2006). These last years this infection has been re-emerging because of descriptions of strains of O. tsutsugamushi with reduced susceptibility to antibiotics and of the surprising interactions between scrub typhus and the human immunodeficiency virus (HIV). It is estimated that more than a million cases of scrub typhus are transmitted annually in Asia and more than a billion people are at risk (Rosenberg 1997).
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32

Laboratory Diagnosis of Infectious Diseases - Principles and Practice : Vol. 2: Viral, Rickettsial, and Chlamydial Diseases. Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1988.

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33

Murphy, Frederick A., Pekka Halonen, and Edwin H. Lennette. Laboratory Diagnosis of Infectious Diseases Principles and Practice: VOLUME II Viral, Rickettsial, and Chlamydial Diseases. Springer London, Limited, 2012.

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34

Murphy, Frederick A., Pekka Halonen, and Edwin H. Lennette. Laboratory Diagnosis of Infectious Diseases Principles and Practice: VOLUME II Viral, Rickettsial, and Chlamydial Diseases. Springer New York, 2011.

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35

Friedman, Herman, Mauro Bendinelli, and Burt Anderson. Microorganisms and Bioterrorism. Springer, 2010.

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