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1

Ugleva, S. V., and S. V. Shabalina. "Ricketsioses in the Lower Volga region." Journal of microbiology, epidemiology and immunobiology 98, no. 2 (May 5, 2021): 231–38. http://dx.doi.org/10.36233/0372-9311-60.

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The aim of this work was to describe the features of the epidemiology and clinic of rickettsioses at the Lower Volga region.Materials and methods. Scientific papers on searchable electronic databases (Web of Science, PubMed, eLIBRARY and ResearchGate) were selected and analyzed. Of the 256 found sources, the authors selected 87, taking into account the keywords, after an analysis of the selected literature, 30 sources were included in the present study in accordance with the topic of the work.Results. On the territory of the Lower Volga region, including the Astrakhan region, two rickettsioses are recorded: rickettsiosis from the tick-borne spotted fevers group — Astrakhan spotted fever (APL) and Q fever (coxiellosis). APL is a relatively new rickettsiosis common in the Caspian Sea basin, along the floodplain of the river Volga to Volgograd, capturing the steppes of Kalmykia. Q fever is recorded in many countries of the world, and in Russia, in terms of its importance and distribution, it occupies one of the first places among endemic diseases. The clinical characteristics of these rickettsioses are also presented.Conclusions. The study of the epidemiology and clinic of rickettsial infections remains relevant.
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2

Nogueras, María Mercedes, Beatriz Roson, Sergio Lario, Isabel Sanfeliu, Immaculada Pons, Esperança Anton, Aurora Casanovas, and Ferran Segura. "Coinfection with “Rickettsia sibirica subsp. mongolotimonae” and Rickettsia conorii in a Human Patient: a Challenge for Molecular Diagnosis Tools." Journal of Clinical Microbiology 53, no. 9 (July 1, 2015): 3057–62. http://dx.doi.org/10.1128/jcm.00457-15.

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Rickettsioses are zoonoses transmitted by vectors. More than one agent can coexist in vectors. Although vectors may transmit more than one microorganism to humans, information on dual infections is scarce. We present a case of a patient with an atypical rickettsiosis diagnosis in whom two species ofRickettsiawere detected.
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3

Raoult, D., and V. Roux. "Rickettsioses as paradigms of new or emerging infectious diseases." Clinical Microbiology Reviews 10, no. 4 (October 1997): 694–719. http://dx.doi.org/10.1128/cmr.10.4.694.

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Rickettsioses are caused by species of Rickettsia, a genus comprising organisms characterized by their strictly intracellular location and their association with arthropods. Rickettsia species are difficult to cultivate in vitro and exhibit strong serological cross-reactions with each other. These technical difficulties long prohibited a detailed study of the rickettsiae, and it is only following the recent introduction of novel laboratory methods that progress in this field has been possible. In this review, we discuss the impact that these practical innovations have had on the study of rickettsiae. Prior to 1986, only eight rickettsioses were clinically recognized; however, in the last 10 years, an additional six have been discovered. We describe the different steps that resulted in the description of each new rickettsiosis and discuss the influence of factors as diverse as physicians' curiosity and the adoption of molecular biology-based identification in helping to recognize these new infections. We also assess the pathogenic potential of rickettsial strains that to date have been associated only with arthropods, and we discuss diseases of unknown etiology that may be rickettsioses.
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4

Berbis, P. "Rickettsioses." EMC - Dermatologie 2, no. 1 (January 2007): 1–10. http://dx.doi.org/10.1016/s0246-0319(07)45223-2.

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5

Lagier, J. C., B. Doudier, and P. Parola. "Rickettsioses." EMC - Traité de médecine AKOS 4, no. 2 (January 2009): 1–6. http://dx.doi.org/10.1016/s1634-6939(09)51283-5.

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6

Raoult, D. "S154 Rickettsioses." International Journal of Antimicrobial Agents 29 (March 2007): S31. http://dx.doi.org/10.1016/s0924-8579(07)70100-0.

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7

Hansmann, Y. "Rickettsioses éruptives." EMC - Maladies infectieuses 6, no. 2 (January 2009): 1–15. http://dx.doi.org/10.1016/s1166-8598(09)44183-8.

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8

Parola, Philippe, and Didier Raoult. "Tropical rickettsioses." Clinics in Dermatology 24, no. 3 (May 2006): 191–200. http://dx.doi.org/10.1016/j.clindermatol.2005.11.007.

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9

Blanton, Lucas S. "The Rickettsioses." Infectious Disease Clinics of North America 33, no. 1 (March 2019): 213–29. http://dx.doi.org/10.1016/j.idc.2018.10.010.

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10

Ando, S., and Y. Ogasawara. "Traveler's rickettsioses and domestic rickettsioses in Japan in 2011." International Journal of Infectious Diseases 16 (June 2012): e337. http://dx.doi.org/10.1016/j.ijid.2012.05.398.

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11

Renvoisé, A., and D. Raoult. "L’actualité des rickettsioses." Médecine et Maladies Infectieuses 39, no. 2 (February 2009): 71–81. http://dx.doi.org/10.1016/j.medmal.2008.11.003.

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12

Portillo, Aránzazu, Sonia Santibáñez, Lara García-Álvarez, Ana M. Palomar, and José A. Oteo. "Rickettsioses in Europe." Microbes and Infection 17, no. 11-12 (November 2015): 834–38. http://dx.doi.org/10.1016/j.micinf.2015.09.009.

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13

Fujita, Hiromi. "Ticks-rickettsioses interface." Medical Entomology and Zoology 48, no. 2 (1997): 153. http://dx.doi.org/10.7601/mez.48.153_1.

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14

Graves, Stephen, and John Stenos. "Rickettsioses in Australia." Annals of the New York Academy of Sciences 1166, no. 1 (May 2009): 151–55. http://dx.doi.org/10.1111/j.1749-6632.2009.04530.x.

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15

GRAVES, S., N. UNSWORTH, and J. STENOS. "Rickettsioses in Australia." Annals of the New York Academy of Sciences 1078, no. 1 (October 1, 2006): 74–79. http://dx.doi.org/10.1196/annals.1374.008.

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16

Jayasundara, MHD, and WKS Kularatne. "Rickettsioses complicated with dry gangrene and thrombotic thrombocytopenic purpura -a case report." Hematology & Transfusion International Journal 9, no. 6 (2021): 109–11. http://dx.doi.org/10.15406/htij.2021.09.00266.

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Background: Spotted fever group rickettsioses has become more apparent in certain provinces of Sri Lanka. It has a vast diversity in its clinical presentation. However, toe gangrene and thrombotic thrombocytopenic purpura are rare presentations of rickettsioses and are less reported to date. Case presentation: Acute febrile illness of a 28year old Army Officer was complicated with seizures, acute kidney injury, toe gangrene and skin necrosis. He was treated as for spotted fever group rickettsioses complicated with dry gangrene and thrombotic thrombocytopenic purpura. Accurate clinical diagnosis and specific treatment resulted in dramatic recovery leaving behind only the residual gangrenous toes. Conclusion: This case report highlights the importance of accurate clinical diagnosis along with timely intervention to determine the outcome of certain detrimental and rare complications of spotted fever group rickettsioses.
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17

Beltrame, Anna, Andrea Angheben, Stefania Casolari, Francesco Castelli, Giacomo Magnani, Giovanni Gaiera, Federica Brillo, et al. "Imported rickettsioses in Italy." Travel Medicine and Infectious Disease 10, no. 4 (July 2012): 201–4. http://dx.doi.org/10.1016/j.tmaid.2012.05.003.

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18

Monegal Ferran, F., J. Ordi Ros, A. Arderiu Freixa, J. Fernandez Cortijo, J. Barquinero Mañez, and M. Vilardell Tarrés. "Anticorps antiphospholipide et rickettsioses." La Revue de Médecine Interne 10, no. 6 (November 1989): 576. http://dx.doi.org/10.1016/s0248-8663(89)80083-9.

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19

Larbi Ammari, F., W. Ben Salem, W. Chebbi, W. Alaya, B. Zantour, and M. H. Sfar. "Rickettsioses chez le diabétique." Annales d'Endocrinologie 75, no. 5-6 (October 2014): 392. http://dx.doi.org/10.1016/j.ando.2014.07.410.

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20

Hechemy, Karim E. "Serodiagnosis of rickettsioses: Revisited." Clinical Immunology Newsletter 8, no. 7 (July 1987): 105–8. http://dx.doi.org/10.1016/0197-1859(87)90043-4.

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21

Turebekov, Nurkeldi, Karlygash Abdiyeva, Ravilya Yegemberdiyeva, Andrey Kuznetsov, Andrey Dmitrovskiy, Lyazzat Yeraliyeva, Zhanna Shapiyeva, et al. "Occurrence of Anti-Rickettsia spp. Antibodies in Hospitalized Patients with Undifferentiated Febrile Illness in the Southern Region of Kazakhstan." American Journal of Tropical Medicine and Hygiene 104, no. 6 (June 2, 2021): 2000–2008. http://dx.doi.org/10.4269/ajtmh.20-0388.

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Abstract.Undifferentiated febrile illness still represents a demanding medical problem all over the world, but primarily in low- and middle-income countries. Scientific and clinical investigations related to undifferentiated febrile illness and rickettsial diseases in Kazakhstan are lacking. This study reflects the investigation of antibodies against spotted fever group (SFG) and typhus group (TG) rickettsiae in patients with undifferentiated febrile illness in the southern region of Kazakhstan (Almaty and Kyzylorda oblasts). Paired serum samples were gathered from 13 hospitals in these two oblasts and explored for the presence of IgM and IgG antibodies against typhus group and IgG antibodies against spotted fever group rickettsiae using ELISA. Patient’s questionnaires were statistically analyzed. In total, 802 inpatients from Almaty (N = 9) and Kyzylorda (N = 4) hospitals were included in this research. Based on ELISA results, 250 patients out of 802 (31.2%) from both oblasts had IgG antibodies against SFG rickettsiae. Results from 11 (1.4%) patients indicated acute infection with tick-borne rickettsiosis. Regarding TG rickettsiae (R. typhi), a past infection was detected in 248 (30.9%) febrile patients and acute infection in 22 (2.7%) patients in the two selected oblasts. The data indicated that SFG and TG rickettsioses are present in Kazakhstan. Kazakh physicians should be aware of these emerging diseases in both investigated oblasts because the occurrence of these diseases is not suspected during day-to-day clinical practice. The identification of rickettsial pathogens and implementation of modern laboratory methods for the diagnostics of rickettsioses are in need throughout Kazakhstan.
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22

&NA;. "Rickettsioses and the International Traveler." Pediatric Infectious Disease Journal 24, no. 2 (February 2005): 194. http://dx.doi.org/10.1097/01.inf.0000154224.96764.79.

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23

Unsworth, Nathan B., John Stenos, Antony G. Faa, and Stephen R. Graves. "Three Rickettsioses, Darnley Island, Australia." Emerging Infectious Diseases 13, no. 7 (July 2007): 1105–7. http://dx.doi.org/10.3201/eid1307.050088.

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24

Blanton, Lucas S., and David H. Walker. "Flea-Borne Rickettsioses and Rickettsiae." American Journal of Tropical Medicine and Hygiene 96, no. 1 (October 31, 2016): 53–56. http://dx.doi.org/10.4269/ajtmh.16-0537.

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25

Oteo, José A., and Aránzazu Portillo. "Tick-borne rickettsioses in Europe." Ticks and Tick-borne Diseases 3, no. 5-6 (December 2012): 271–78. http://dx.doi.org/10.1016/j.ttbdis.2012.10.035.

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26

Letonturier, Philippe. "Regain d’intérêt pour les rickettsioses." La Presse Médicale 33, no. 1 (January 2004): 70. http://dx.doi.org/10.1016/s0755-4982(04)98486-2.

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27

Watt, George, and Philippe Parola. "Scrub typhus and tropical rickettsioses." Current Opinion in Infectious Diseases 16, no. 5 (October 2003): 429–36. http://dx.doi.org/10.1097/00001432-200310000-00009.

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28

Azad, Abdu. "Flea-borne Rickettsioses: Ecologic Considerations." Emerging Infectious Diseases 3, no. 3 (September 1997): 319–27. http://dx.doi.org/10.3201/eid0303.970308.

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29

SEKEYOVÁ, Z., C. SOCOLOVSCHI, E. ŠPITALSKÁ, E. KOCIANOVÁ, V. BOLDIŠ, M. QUEVEDO DIAZ, L. BERTHOVÁ, et al. "Update on Rickettsioses in Slovakia." Acta virologica 57, no. 02 (2013): 180–99. http://dx.doi.org/10.4149/av_2013_02_180.

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30

Bacellar, F., M. S. Núncio, J. Řeháček, and A. R. Filipe. "Rickettsiae and rickettsioses in Portugal." European Journal of Epidemiology 7, no. 3 (May 1991): 291–93. http://dx.doi.org/10.1007/bf00145680.

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31

Sood, Ashwani K., and Amit Sachdeva. "Rickettsioses in Children – A Review." Indian Journal of Pediatrics 87, no. 11 (February 28, 2020): 930–36. http://dx.doi.org/10.1007/s12098-020-03216-z.

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32

Ericsson, C. D., M. Jensenius, P. E. Fournier, and D. Raoult. "Rickettsioses and the International Traveler." Clinical Infectious Diseases 39, no. 10 (November 15, 2004): 1493–99. http://dx.doi.org/10.1086/425365.

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33

PAROLA, P. "Rickettsioses in Sub-Saharan Africa." Annals of the New York Academy of Sciences 1078, no. 1 (October 1, 2006): 42–47. http://dx.doi.org/10.1196/annals.1374.005.

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34

Rodino, Kyle G. "Rickettsioses in the United States." Clinical Microbiology Newsletter 41, no. 13 (July 2019): 113–19. http://dx.doi.org/10.1016/j.clinmicnews.2019.06.002.

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35

Bora, T., and S. A. Khan. "Emerging rickettsioses in Northeast India." International Journal of Infectious Diseases 45 (April 2016): 167. http://dx.doi.org/10.1016/j.ijid.2016.02.396.

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36

Quintal, Diane. "Historical aspects of the rickettsioses." Clinics in Dermatology 14, no. 3 (May 1996): 237–42. http://dx.doi.org/10.1016/0738-081x(96)00007-7.

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37

Marschang, A., H. D. Nothdurft, Susanna Kumlien, and F. von Sonnenburg. "Imported rickettsioses in German travelers." Infection 23, no. 2 (March 1995): 94–97. http://dx.doi.org/10.1007/bf01833873.

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38

Mediannikov, O., and I. Tarasevich. "Spotted Group Rickettsioses in Asia." International Journal of Infectious Diseases 12 (December 2008): e42. http://dx.doi.org/10.1016/j.ijid.2008.05.155.

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39

Arroyave, Esteban, Ilirjana Hyseni, Nicole Burkhardt, Yong-Fang Kuo, Tian Wang, Ulrike Munderloh, and Rong Fang. "Rickettsia parkeri with a Genetically Disrupted Phage Integrase Gene Exhibits Attenuated Virulence and Induces Protective Immunity against Fatal Rickettsioses in Mice." Pathogens 10, no. 7 (June 30, 2021): 819. http://dx.doi.org/10.3390/pathogens10070819.

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Although rickettsiae can cause life-threatening infections in humans worldwide, no licensed vaccine is currently available. To evaluate the suitability of live-attenuated vaccine candidates against rickettsioses, we generated a Rickettsia parkeri mutant RPATATE_0245::pLoxHimar (named 3A2) by insertion of a modified pLoxHimar transposon into the gene encoding a phage integrase protein. For visualization and selection, R. parkeri 3A2 expressed mCherry fluorescence and resistance to spectinomycin. Compared to the parent wild type (WT) R. parkeri, the virulence of R. parkeri 3A2 was significantly attenuated as demonstrated by significantly smaller size of plaque, failure to grow in human macrophage-like cells, rapid elimination of Rickettsia and ameliorated histopathological changes in tissues in intravenously infected mice. A single dose intradermal (i.d.) immunization of R. parkeri 3A2 conferred complete protection against both fatal R. parkeri and R. conorii rickettsioses in mice, in association with a robust and durable rickettsiae-specific IgG antibody response. In summary, the disruption of RPATATE_0245 in R. parkeri resulted in a mutant with a significantly attenuated phenotype, potent immunogenicity and protective efficacy against two spotted fever group rickettsioses. Overall, this proof-of-concept study highlights the potential of R. parkeri mutants as a live-attenuated and multivalent vaccine platform in response to emergence of life-threatening spotted fever rickettsioses.
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40

Parola, Philippe, Christopher D. Paddock, and Didier Raoult. "Tick-Borne Rickettsioses around the World: Emerging Diseases Challenging Old Concepts." Clinical Microbiology Reviews 18, no. 4 (October 2005): 719–56. http://dx.doi.org/10.1128/cmr.18.4.719-756.2005.

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SUMMARY During most of the 20th century, the epidemiology of tick-borne rickettsioses could be summarized as the occurrence of a single pathogenic rickettsia on each continent. An element of this paradigm suggested that the many other characterized and noncharacterized rickettsiae isolated from ticks were not pathogenic to humans. In this context, it was considered that relatively few tick-borne rickettsiae caused human disease. This concept was modified extensively from 1984 through 2005 by the identification of at least 11 additional rickettsial species or subspecies that cause tick-borne rickettsioses around the world. Of these agents, seven were initially isolated from ticks, often years or decades before a definitive association with human disease was established. We present here the tick-borne rickettsioses described through 2005 and focus on the epidemiological circumstances that have played a role in the emergence of the newly recognized diseases.
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41

Parola, Philippe, Clarisse Rovery, Jean Marc Rolain, Philippe Brouqui, Bernard Davoust, and Didier Raoult. "Rickettsia slovacaandR. raoultiiin Tick-borne Rickettsioses." Emerging Infectious Diseases 15, no. 7 (July 2009): 1105–8. http://dx.doi.org/10.3201/eid1507.081449.

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42

Renvoisé, A., and D. Raoult. "Quoi de neuf sur les Rickettsioses ?" La Revue de Médecine Interne 30 (June 2009): S19—S21. http://dx.doi.org/10.1016/j.revmed.2009.03.001.

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43

Katz, Arnon M. "Vibrio Infections and Rickettsioses: Summary Notes." Journal of Cutaneous Medicine and Surgery 3, no. 5 (July 1999): 247–48. http://dx.doi.org/10.1177/120347549900300507.

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44

Rahman, Adnan, Anders Tegnell, Sirkka Vene, and Johan Giesecke. "Rickettsioses in Swedish Travellers, 1997-2001." Scandinavian Journal of Infectious Diseases 35, no. 4 (January 2003): 247–50. http://dx.doi.org/10.1080/00365540310005422.

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45

Ma, Jui-Shan. "Rickettsioses in South Korea, Data Analysis." Emerging Infectious Diseases 12, no. 3 (March 2006): 531–32. http://dx.doi.org/10.3201/eid1203.050957.

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46

Van Der Kleij, Gansevoort, Kreeftenberg, and Reitsma. "Imported rickettsioses: think of murine typhus." Journal of Internal Medicine 243, no. 2 (February 1998): 177–79. http://dx.doi.org/10.1046/j.1365-2796.1998.00266.x.

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47

Widjaja, Susana, Maya Williams, Imelda Winoto, Arik Farzeli, Craig A. Stoops, Kathryn A. Barbara, Allen L. Richards, and Patrick J. Blair. "Geographical Assessment of Rickettsioses in Indonesia." Vector-Borne and Zoonotic Diseases 16, no. 1 (January 2016): 20–25. http://dx.doi.org/10.1089/vbz.2015.1840.

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48

Raoult, Didier. "Emerging Rickettsioses Reach the United States." Clinical Infectious Diseases 51, no. 1 (July 2010): 121–22. http://dx.doi.org/10.1086/653451.

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49

LETAIEF, A. "Epidemiology of Rickettsioses in North Africa." Annals of the New York Academy of Sciences 1078, no. 1 (October 1, 2006): 34–41. http://dx.doi.org/10.1196/annals.1374.004.

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50

WEN, G., J. W. MCBRIDE, X. ZHANG, and J. P. OLANO. "Early Diagnosis of Rickettsioses by Electrochemiluminscence." Annals of the New York Academy of Sciences 1078, no. 1 (October 1, 2006): 590–94. http://dx.doi.org/10.1196/annals.1374.118.

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