Academic literature on the topic 'Rickettsiosi'
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Journal articles on the topic "Rickettsiosi"
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Ugleva, S. V., and S. V. Shabalina. "Ricketsioses in the Lower Volga region." Journal of microbiology, epidemiology and immunobiology 98, no. 2 (May 5, 2021): 231–38. http://dx.doi.org/10.36233/0372-9311-60.
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The aim of this work was to describe the features of the epidemiology and clinic of rickettsioses at the Lower Volga region.Materials and methods. Scientific papers on searchable electronic databases (Web of Science, PubMed, eLIBRARY and ResearchGate) were selected and analyzed. Of the 256 found sources, the authors selected 87, taking into account the keywords, after an analysis of the selected literature, 30 sources were included in the present study in accordance with the topic of the work.Results. On the territory of the Lower Volga region, including the Astrakhan region, two rickettsioses are recorded: rickettsiosis from the tick-borne spotted fevers group — Astrakhan spotted fever (APL) and Q fever (coxiellosis). APL is a relatively new rickettsiosis common in the Caspian Sea basin, along the floodplain of the river Volga to Volgograd, capturing the steppes of Kalmykia. Q fever is recorded in many countries of the world, and in Russia, in terms of its importance and distribution, it occupies one of the first places among endemic diseases. The clinical characteristics of these rickettsioses are also presented.Conclusions. The study of the epidemiology and clinic of rickettsial infections remains relevant.
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Martínez-Caballero, A., B. Moreno, C. González, G. Martínez, M. Adames, J. V. Pachar, J. B. Varela-Petrucelli, et al. "Descriptions of two new cases of Rocky Mountain spotted fever in Panama, and coincident infection with Rickettsia rickettsii in Rhipicephalus sanguineus s.l. in an urban locality of Panama City, Panama." Epidemiology and Infection 146, no. 7 (April 5, 2018): 875–78. http://dx.doi.org/10.1017/s0950268818000730.
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AbstractThe clinical and pathologic characterisation of two fatal cases of tick-borne rickettsiosis in rural (El Valle) and urban (City of Panama) Panama are described. Clinical and autopsy findings were non-specific, but the molecular analysis was used to identify Rickettsia rickettsii in both cases. No ticks were collected in El Valle, while in the urban case, R. rickettsii was detected in Rhipicephalus sanguineus s.l., representing the first molecular finding in this tick in Panama and Central America.
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Nogueras, María Mercedes, Beatriz Roson, Sergio Lario, Isabel Sanfeliu, Immaculada Pons, Esperança Anton, Aurora Casanovas, and Ferran Segura. "Coinfection with “Rickettsia sibirica subsp. mongolotimonae” and Rickettsia conorii in a Human Patient: a Challenge for Molecular Diagnosis Tools." Journal of Clinical Microbiology 53, no. 9 (July 1, 2015): 3057–62. http://dx.doi.org/10.1128/jcm.00457-15.
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Rickettsioses are zoonoses transmitted by vectors. More than one agent can coexist in vectors. Although vectors may transmit more than one microorganism to humans, information on dual infections is scarce. We present a case of a patient with an atypical rickettsiosis diagnosis in whom two species ofRickettsiawere detected.
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Gafarova, M. T., E. I. Bondarenko, K. D. Maliy, E. E. Alieva, I. L. Evstafiev, N. N. Tovpinec, N. K. Malaya, and A. V. Kubyshkin. "Prevalence of causative agents of transmissive tick-borned ricketsious in the Crimean peninsula." Russian Clinical Laboratory Diagnostics 67, no. 3 (March 25, 2022): 170–76. http://dx.doi.org/10.51620/0869-2084-2022-67-3-170-176.
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The paper presents the results of a study of the prevalence of Ixodid ticks - potential carriers of tick-borne rickettsiosis pathogens. Ectoparasites were collected in various natural and climatic zones of the Crimean Peninsula within the year 2016-2018. As a result of screening with the help of real-time PCR analysis (PCR-RT), a genetic marker (a section of the gltA gene) of the rickettsia group of tick-borne spotted fever was detected in ticks. The most common DNA marker of rickettsia was found in ticks in the eastern regions of the steppe zone - 50,6 %, in the north-western part of the steppe zone this value was 12,0 %. The least amount of rickettsia target DNA was detected in ticks collected in the mountain forest and south bank zones - 4,5 %. As a result of sequencing of positive DNA samples from fragments of the gltA, ompA, ompB, and sca4 genes, the species composition of rickettsias was established. The DNA of 8 species of rickettsia was identified: Circulation of three R. conorii, R. massiliae, R. sibirica subsp. mongolotimonae, R. slovaca, R. aeschlimannii, R. monacensis, R. helvetica, R. raoultii. R. massiliae, R. slovaca, and R. helvetica were established in the Crimean Peninsula for the first time. The peculiarities of the geographical distribution of the identified rickettsia species were determined, which was due to the spread of mites-carriers of pathogens. The revealed diversity of rickettsia species and their vectors, due to the isolation of the areas of the main feeding animals and the established routes of migratory birds, suggests the circulation of other rickettsia species on the territory of the Crimean Peninsula. The obtained results suggest that the diseases of tick-borne rickettsiosis in the Crimean Peninsula can be caused not only by R. conorii, as previously thought, but also by other types of rickettsii.
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Conti-Díaz, Ismael A., Jonas Moraes-Filho, Richard C. Pacheco, and Marcelo B. Labruna. "Serological evidence of Rickettsia parkeri as the etiological agent of rickettsiosis in Uruguay." Revista do Instituto de Medicina Tropical de São Paulo 51, no. 6 (December 2009): 337–39. http://dx.doi.org/10.1590/s0036-46652009000600005.
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We report three new rickettsiosis human cases in Uruguay. The three clinical cases presented clinical manifestations similar to previous reported cases of Rickettsia parkeri in the United States; that is mild fever (< 40 ºC), malaise, headache, rash, inoculation eschar at the tick bite site, regional lymphadenopathy, and no lethality. Serological antibody-absorption tests with purified antigens of R. parkeri and Rickettsia rickettsii, associated with immunofluorescence assay indicated that the patients in two cases were infected by R. parkeri. Epidemiological and clinical evidences, coupled with our serological analysis, suggest that R. parkeri is the etiological agent of human cases of spotted fever in Uruguay, a disease that has been recognized in that country as cutaneous-ganglionar rickettsiosis.
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Lang, Susanne, Tobias Bergmann, Diana-Maria Kuschel, and Helmut Schiffl. "Komplizierte Zeckenstich-Rickettsiose nach Safari-Tour in Südafrika." DMW - Deutsche Medizinische Wochenschrift 143, no. 15 (July 30, 2018): 1116–19. http://dx.doi.org/10.1055/a-0622-7606.
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Zusammenfassung Anamnese und klinischer Befund Ein 41-jähriger, bis dato gesunder Mann zog sich während einer Safaritour im Krüger Nationalpark einen Zeckenstich zu. 5 Tage später bekam er hohes Fieber mit schwerem Krankheitsgefühl. An der Zeckenstichstelle entwickelte sich ein charakteristisches Ulkus mit schwärzlichem Grund, Schorfbildung und rotem Hof (Eschar, Tache noir). Reise -und Zeckenstichanamnese legten den Verdacht einer Rickettsiose nahe. Untersuchungen und Diagnose Die Diagnose einer Rickettsiose aus der Zeckenstichfiebergruppe (spotted-fever-group) wurde serologisch bestätigt. Der klinische Verlauf der Rickettsiose wurde durch eine Myokarditis kompliziert, die zunächst nur durch ein erhöhtes Troponin-I auffiel und später mittels Kardio-MRT bestätigt wurde. Der komplizierte Verlauf und der singuläre Eschar sprechen für eine Infektion mit Rickettsia conorii. Therapie und Verlauf Es kam es zu einer raschen Rückbildung der Symptome der febrilen Infektionserkrankung unter der Therapie mit Doxycyclin. Die Rekonvaleszenz der importierten Reisekrankheit war durch die Myokarditis verzögert. Folgerung Rickettsiosen sollten bei Afrikareisenden differenzialdiagnostisch in Erwägung gezogen werden. Sie verlaufen in der Regel mild; komplizierte Verläufe können auch bei gesunden jungen Menschen auftreten.
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Raoult, D., and V. Roux. "Rickettsioses as paradigms of new or emerging infectious diseases." Clinical Microbiology Reviews 10, no. 4 (October 1997): 694–719. http://dx.doi.org/10.1128/cmr.10.4.694.
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Rickettsioses are caused by species of Rickettsia, a genus comprising organisms characterized by their strictly intracellular location and their association with arthropods. Rickettsia species are difficult to cultivate in vitro and exhibit strong serological cross-reactions with each other. These technical difficulties long prohibited a detailed study of the rickettsiae, and it is only following the recent introduction of novel laboratory methods that progress in this field has been possible. In this review, we discuss the impact that these practical innovations have had on the study of rickettsiae. Prior to 1986, only eight rickettsioses were clinically recognized; however, in the last 10 years, an additional six have been discovered. We describe the different steps that resulted in the description of each new rickettsiosis and discuss the influence of factors as diverse as physicians' curiosity and the adoption of molecular biology-based identification in helping to recognize these new infections. We also assess the pathogenic potential of rickettsial strains that to date have been associated only with arthropods, and we discuss diseases of unknown etiology that may be rickettsioses.
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Narra, Hema P., Abha Sahni, Krishna Mohan Sepuru, Jessica Alsing, and Sanjeev K. Sahni. "Sensing the Messenger: Potential Roles of Cyclic-di-GMP in Rickettsial Pathogenesis." International Journal of Molecular Sciences 23, no. 7 (March 31, 2022): 3853. http://dx.doi.org/10.3390/ijms23073853.
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Pathogenic bacteria causing human rickettsioses, transmitted in nature by arthropod vectors, primarily infect vascular endothelial cells lining the blood vessels, resulting in ‘endothelial activation’ and onset of innate immune responses. Nucleotide second messengers are long presumed to be the stimulators of type I interferons, of which bacterial cyclic-di-GMP (c-di-GMP) has been implicated in multiple signaling pathways governing communication with other bacteria and host cells, yet its importance in the context of rickettsial interactions with the host has not been investigated. Here, we report that all rickettsial genomes encode a putative diguanylate cyclase pleD, responsible for the synthesis of c-di-GMP. In silico analysis suggests that although the domain architecture of PleD is apparently well-conserved among different rickettsiae, the protein composition and sequences likely vary. Interestingly, cloning and sequencing of the pleD gene from virulent (Sheila Smith) and avirulent (Iowa) strains of R. rickettsii reveals a nonsynonymous substitution, resulting in an amino acid change (methionine to isoleucine) at position 236. Additionally, a previously reported 5-bp insertion in the genomic sequence coding for pleD (NCBI accession: NC_009882) was not present in the sequence of our cloned pleD from R. rickettsii strain Sheila Smith. In vitro infection of HMECs with R. rickettsii (Sheila Smith), but not R. rickettsii (Iowa), resulted in dynamic changes in the levels of pleD up to 24 h post-infection. These findings thus provide the first evidence for the potentially important role(s) of c-di-GMP in the determination of host-cell responses to pathogenic rickettsiae. Further studies into molecular mechanisms through which rickettsial c-di-GMP might regulate pathogen virulence and host responses should uncover the contributions of this versatile bacterial second messenger in disease pathogenesis and immunity to human rickettsioses.
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Stanley, Hannah M., Shelby L. Ford, Alyssa N. Snellgrove, Kris Hartzer, Emily B. Smith, Inna Krapiunaya, and Michael L. Levin. "The Ability of the Invasive Asian Longhorned Tick Haemaphysalis longicornis (Acari: Ixodidae) to Acquire and Transmit Rickettsia rickettsii (Rickettsiales: Rickettsiaceae), the Agent of Rocky Mountain Spotted Fever, Under Laboratory Conditions." Journal of Medical Entomology 57, no. 5 (April 27, 2020): 1635–39. http://dx.doi.org/10.1093/jme/tjaa076.
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Abstract The invasive Asian longhorned tick, Haemaphysalis longicornis Neumann, was first detected in the United States in 2017. It has since been found in 12 states, and there is concern that the tick’s parthenogenetic ability and wide variety of host species may allow for broader dissemination. Of the tick-borne diseases endemic to the United States, Rocky Mountain spotted fever (RMSF), a rapidly progressive and potentially fatal disease caused by Rickettsia rickettsii, is the most severe. There is considerable geographical overlap between spotted fever rickettsioses cases, which include RMSF, and the currently known distribution of H. longicornis, providing the potential for this tick to encounter this pathogen. We have evaluated the ability of H. longicornis to acquire and transmit R. rickettsii under laboratory conditions. Haemaphysalis longicornis as larvae and nymphs acquired the pathogen while feeding on infected guinea pigs. The infection persisted through every life stage, all of which were able to transmit R. rickettsii to naïve hosts. The pathogen was also transmitted at a low frequency between generations of H. longicornis through the ova. While H. longicornis was demonstrated to be a competent vector for R. rickettsii under laboratory conditions, the probability of its involvement in the maintenance and transmission of this pathogen in nature, as well as its potential impact on human health, requires further study.
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Kristof, M. Nathan, Paige E. Allen, Lane D. Yutzy, Brandon Thibodaux, Christopher D. Paddock, and Juan J. Martinez. "Significant Growth by Rickettsia Species within Human Macrophage-Like Cells Is a Phenotype Correlated with the Ability to Cause Disease in Mammals." Pathogens 10, no. 2 (February 19, 2021): 228. http://dx.doi.org/10.3390/pathogens10020228.
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Rickettsia are significant sources of tick-borne diseases in humans worldwide. In North America, two species in the spotted fever group of Rickettsia have been conclusively associated with disease of humans: Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, and Rickettsia parkeri, the cause of R. parkeri rickettsiosis. Previous work in our lab demonstrated non-endothelial parasitism by another pathogenic SFG Rickettsia species, Rickettsia conorii, within THP-1-derived macrophages, and we have hypothesized that this growth characteristic may be an underappreciated aspect of rickettsial pathogenesis in mammalian hosts. In this work, we demonstrated that multiple other recognized human pathogenic species of Rickettsia, including R. rickettsii, R. parkeri, Rickettsia africae, and Rickettsiaakari can grow within target endothelial cells as well as within PMA-differentiated THP-1 cells. In contrast, Rickettsia bellii, a Rickettsia species not associated with disease of humans, and R. rickettsii strain Iowa, an avirulent derivative of pathogenic R. rickettsii, could invade both cell types but proliferate only within endothelial cells. Further analysis revealed that similar to previous studies on R. conorii, other recognized pathogenic Rickettsia species could grow within the cytosol of THP-1-derived macrophages and avoided localization with two different markers of lysosomal compartments; LAMP-2 and cathepsin D. R. bellii, on the other hand, demonstrated significant co-localization with lysosomal compartments. Collectively, these findings suggest that the ability of pathogenic rickettsial species to establish a niche within macrophage-like cells could be an important factor in their ability to cause disease in mammals. These findings also suggest that analysis of growth within mammalian phagocytic cells may be useful to predict the pathogenic potential of newly isolated and identified Rickettsia species.
Dissertations / Theses on the topic "Rickettsiosi"
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Beati, Lorenza. "Approche moléculaire de l'épidémiologie des rickettsioses du groupe boutonneux : spécificité du rapport tiques-rickettsies." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX22055.
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Dans ce travail nous avons compare les methodes (traditionnelles et de biologie moleculaire) permettant de differencier les rickettsies du groupe boutonneux. Cette etude, dont le cadre geographique se situe en europe et en afrique, a abouti a la description de trois nouvelles rickettsies a pathogenicite inconnue et de deux nouvelles rickettsies pathogenes pour l'homme. Le fait qu'il y ait de nouvelles rickettsies et de nouveaux vecteurs potentiels, dans des regions ou la fievre boutonneuse mediterraneenne est endemique, souleve un certain nombre de problemes d'ordre epidemiologique (specificite du rapport tiques-rickettsies) clinique (pathogenicite pour l'homme, effet de la presence de nouvelles rickettsies sur la seroprevalence des rickettsioses) et taxonomiques (definition de l'espece rickettsienne)
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Corrain, Raffaela. "Indagini in ambienti silvestri e periurbani del Nord Italia su alcuni patogeni trasmessi da zecche." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426523.
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Aim of the present work is to improve knowledge on ecology of Ixodes ricinus ticks, on epidemiology of some zoonotic agent (Anaplasma phagocytophilum, Bartonella henselae, Bartonella clarridgeiae, Borrelia burgdorferi s.l., Richettsia helvetica, Rickettsia monacensis and Tick-borne encephalitis virus) and to define human risk to bite exposure.
Study areas were some sites in the mountain habitats of the eastern Italian Alps and four public parks around Imola, province of Bologna. PCR were used for identification of all pathogens. Host seeking Ixodes ricinus ticks were harvested by dragging along transect of 100m. Density of ticks and association of prevalences of zoonotic inections in ticks with environmental variables (year, season, temperature, relative humidity, monthly rain, mean monthly temperature, vegetation cover, altitude) were evaluated using regression models.
Presence of three zoonotic agents, Anaplasma phagocytophilum (Human Granulocitic Erlichiosis agent), Borrelia burgdorferi s.l. (Lyme disease agent) and Tick-borne encephalitis virus (TBE) was surveyed in the mountain habitats.
In periurban parks Anaplasma phagocytophilum, Borrelia burgdorferi s.l., Bartonella henselae and B. clarridgeiae (cat scratch disease agents), Rickettsia helvetica and R. monacensis, two emerging rickettsial agents, were found.
Acarological Risk, defined as probability of collecting at least one infected nymph along a 100m transect, were calculated as estimate of human risk of infection by each of the pathogens found.
Results showed a high occurrence of Ixodes ricinus ticks in different habitats, with hot spots in some locality of mountain habitats, attributable to higher density of micromammals. Their abundance was also associated with season (higher abundance in spring and autumn) and vegetation cover.
Borrelia burgdorferi s.l was widespread in wild and periurban habitats. A. phagocytophilum was present only in some localities in mountain habitats, with prevalence lower than 2%.
B.henselae infection resulted surprisingly high in ticks from one of the public parks although it has typically a domestic cycle, with fleas (Ctenocephalides felis ) as vector and cats as reservoir. It can be therefore hypothesized that public parks may represent a link between the two cycles. Also the presence of R. helvetica and R. monacensis in public parks is an unexpected outcome: only few years ago these microorganismes were considered only as endosymbiont parasites of Ixodes ricinus and little is known about their epidemiology.
The Acarological Risk values calculated show that public parks may represent a disregarded threat to public health, and that these areas should be surveyed, especially when high vegetation and animal densities may support increasing tick abundances.Lo scopo della tesi è lo studio dell’ecologia di Ixodes ricinus e dell’epidemiologia di alcuni agenti zoonosici (Anaplasma phagocytophilum, Bartonella henselae, Bartonella clarridgeiae, Borrelia burgdorferi s.l., Richettsia helvetica, Rickettsia monacensis e il virus della Tick-borne encephalitis) e la stima del rischio per l’uomo di contrarre queste infezioni. Le aree di studio sono quelle tipicamente silvestri delle Prealpi del nord-est dell’Italia (nelle province di Verona, Vicenza, Treviso, Pordenone e Udine) e quelle periurbane di una cittadina del nord Italia (Imola, Bologna). In entrambe le indagini è stata stimata la densità delle ninfe di Ixodes ricinus (numero di ninfe per 100m2) raccolte mediante la metodica del dragging lungo transetti di 100m ed è stata valutata l’influenza delle variabili stagionali (temperatura e umidità relativa del transetto, temperature medie massime mensili, piovosità mensile, umidità relativa mensile) ed ambientali (tipo di vegetazione ed altitudine) mediante modelli di regressione binomiali negativi Nell’indagine svolta nelle aree silvestri la ricerca riguardante gli agenti patogeni si è concentrata sulla identificazione mediante Real-Time PCR di 3 patogeni: l’Anaplasma phagocytophilum (agente dell’Erlichiosi granulocitica umana), Borrelia burgdorferi s.l. (agente della malattia di Lyme) e del virus della Tick-borne encephalitis (TBE) mentre lo studio che ha coinvolto alcuni parchi della città di Imola ha evidenziato la presenza di Anaplasma phagocytophilum di Borrelia burgdorferi s.l., di Bartonella henselae e B. clarridgeiae, di Richettsia helvetica e R. monacensis, ritenute rickettsiosi emergenti. L’identificazione della presenza di tutti questi patogeni è stata effettuata con PCR classica. È stata quindi valutata mediante modelli di regressione logistica la relazione tra prevalenza e fattori di rischio quali i mesi di campionamento, anno e abbondanza di zecche. E’ stato inoltre quantificato il rischio per l’uomo chiamato anche rischio acarologico, definendolo come la probabilità di trovare almeno una ninfa infetta in 100m di transetto. I risultati ottenuti dimostrano una elevata diffusione della zecca Ixodes ricinus in habitat differenti, con dei picchi di densità in alcune aree probabilmente dovuti alle densità di micromammiferi presenti, che nei modelli di regressione non è stato possibile quantificare. Le indagini hanno confermato che l’abbondanza è influenzata notevolmente dalla stagione, con dei picchi primaverili ed autunnali, come in altre aree d’Europa, ma anche dalla tipologia di vegetazione. Riguardo agli aspetti epidemiologici, viene confermata l’endemia di Borrelia burgdorferi s.l. in habitat silvestri e habitat periurbani, mentre Anaplasma phagocytophilum è presente in focolai con prevalenze più basse del 2% solo in alcune province (Udine, Pordenone, Treviso). Di particolare interesse sono i risultati riguardanti la diffusione di B.henselae nelle zecche, poiché i il principale agente della CSD è generalmente associato ad un tipico ciclo domestico che ha come ospite reservoir il gatto e come vettore la pulce (Ctenocephalides felis). I parchi periurbani potrebbero quindi rappresentare un interfaccia tra cicli domestici e cicli selvatici. Lo stesso fenomeno non è ipotizzabile per B.clarridgeiae, data la scarsa prevalenza nelle zecche. Interessanti anche i risultati per Richettsia helvetica e R.monacensis, dimostrati essere da poco non solo endosimbionti di Ixodes ricinus, ma causa anche di zoonosi. Nonostante le disomogeneità evidenziate anche dai valori del rischio acarologico, il rischio di infettarsi per l’uomo in habitat periurbani non è trascurabile, considerando anche la maggior frequentazione per le attività ricreative rispetto ad habitat silvestri.
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CORDEIRO, Matheus Dias. "Diagn?stico sorol?gico de Rickettsia spp. e Borrelia spp. em c?es no munic?pio de Serop?dica, RJ." Universidade Federal Rural do Rio de Janeiro, 2012. https://tede.ufrrj.br/jspui/handle/jspui/1524.
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CNPq
Brazilian Spotted Fever and Baggio-Yoshinari Syndrome are emerging diseasest characterized as the only known to tick-borne zoonoses in Brazil. This study aimed to avaluate IgG antibodies against Borrelia burgdorferi and Rickettsia rickettsii in stray and domiciled dogs from Serop?dica-RJ and studying the fauna of ixodida these animals. To investigate the prevalence of antibodies against R. rickettsii and B. burgdorferi was performed to collect blood from 293 dogs in four areas of the city of Serop?dica-RJ. Serum samples were processed by Indirect Immunofluorescence (IFA) against crude antigens of R. rickettsii. The same animals were tested for IgG antibodies against B. burgdorferi strain of North American origin, using the Indirect Enzyme-linked immunosorbent assay (ELISA). To confirm the presence of Borrelia spp., 102 positive samples were tested by Western Blotting (WB). Ticks were also collected from the inspection of the animals. The specimens found were manually removed and stored in polypropylene bottles, and later identified. The association between seropositive animals and variables, were performed using the chi-square and analysis of variance (ANOVA) with significance level of 5%. Of the 283 sera tested by IFA, 23.67% (67/283) showed reactivity against species-specific antigens of R. rickettsii. Thus, we found a prevalence of 21.11% (19/90) in "40 km", 21.84% (19/87) in "Km 49", 25% (8 / 32) in "54 km" and 28.38% (21/74) in UFRRJ. The titles ranged from 1:64 to 1:512. On the other hand, of the 293 animals studied, 154 (52.56%) were positive for homologous antibodies anti-B. burgdorferi. It was founded a prevalence of 43.75% (14/32) in the "54 km", 51.72% (45/87) in the "49 km", 46.67% (42/90) in the "40 km" and 63.1% (53/84) in UFRRJ. It was no significant difference (p<0.05) between the prevalence of antibodies against Borrelia sp. in stray dogs and domiciled. Dogs with access to the street had a frequency against R. rickettsii significantly (p<0.05) greater than animals kept in prison. There were no statistical differences (p>0.05) the relationship between the variables: presence of ticks, animal sex, habits, frequenting pastures and age of the animals with seropositivity observed in either species. Regarding ticks, at least 64.5% (189/293) dogs were infested with ticks at the moment of collection. Only two species of ticks were identified, Rhipicephalus sanguineus and Amblyomma cajennense. The presence of antibodies anti-R. rickettsii and anti-B. burgdorferi in dogs from Serop?dica-RJ is indicative of the presence of rickettsias of the Rock Mountain Spotted Fever Group and spirochetes dogs in this area.
A Febre Maculosa Brasileira e a S?ndrome de Baggio-Yoshinari s?o enfermidades emergentes, caracterizadas como as ?nicas zoonoses conhecidamente transmitidas por carrapatos, no Brasil. O presente estudo teve como objetivo detectar anticorpos da classe IgG contra Rickettsia rickettsii e Borrelia burgdorferi e estudar a fauna de Ixod?deos nesses animais. Para investigar a preval?ncia de anticorpos contra R. rickettsii e B. burgdorferi foi efetuada a coleta de sangue de 293 c?es, em quatro ?reas do munic?pio de Serop?dica-RJ. Os soros obtidos foram processados atrav?s da Rea??o de Imunofluoresc?ncia Indireta (RIFI), contra ant?genos brutos de R. rickettsii. Os mesmos animais foram submetidos ? pesquisa de anticorpos hom?logos da classe IgG contra B. burgdorferi cepa americana G39/40, utilizando Ensaio de Imunoadsor??o Enzim?tico (ELISA) Indireto. Para confirma??o da presen?a de Borrelia spp. no munic?pio, 102 amostras positivas foram testadas pelo Western Blotting (WB). A fauna de ixod?deos foi estudada atrav?s da coleta de carrapatos a partir da inspe??o das regi?es das orelhas, dorso e coxins palmares e plantares dos animais. Os esp?cimes encontrados foram removidos manualmente e acondicionados em frascos de polipropileno, e posteriormente, identificados. O estudo da associa??o entre animais soropositivos e as vari?veis avaliadas, foram realizados por meio do teste de Qui-quadrado e An?lise de Vari?ncia (ANOVA), com n?vel de signific?ncia de 5%. Dos 283 soros testados ? RIFI, 23,67% (67/283) apresentaram reatividade contra ant?genos esp?cie-espec?fico de R. rickettsii, sendo encontrada uma frequ?ncia de 21,11% (19/90) no ?Km 40?, 21,84% (19/87) no ?Km 49?, 25% (8/32) no ?Km 54? e 28,38% (21/74) no campus da UFRRJ. A titula??o variou entre 1:64 ? 1:512. Por outro lado, dos 293 animais estudados, 154 (52,56%) foram positivos para anticorpos hom?logos anti-B. burgdorferi, sendo encontrada uma frequ?ncia de 43,75% (14/32) no ?Km 54?, 51,72% (45/87) no ?Km 49?, 46,67% (42/90) no ?Km 40? e 63,1% (53/84) na UFRRJ. Houve diferen?a significativa (p<0,05) entre as preval?ncias de anticorpos contra Borrelia spp. encontradas em caninos errantes e domiciliados. Os c?es com acesso a rua tiveram uma frequ?ncia de anticorpos contra R. rickettsii significativamente (p<0,05) maior que animais mantidos preso. N?o foram observadas diferen?as estat?sticas (p>0,05) entre a rela??o das vari?veis: presen?a de carrapatos, sexo dos animais, h?bitos de frequentar pastos e idade dos animais com a soropositividade observada em nenhuma das duas esp?cies. Quanto aos carrapatos, 64,5% (189/293) dos c?es estavam infestados por carrapatos no momento da coleta. Apenas duas esp?cies de carrapatos foram identificadas, Rhipicephalus sanguineus e Amblyomma cajennense. A presen?a de anticorpos hom?logos anti-R. rickettsii e anti-B. burgdorferi em caninos de Serop?dica-RJ ? um indicativo da presen?a de rickettsia do grupo da Febre Maculosa e espiroquetas em c?es nesta ?rea.
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Navarro, Daniel Leal. "Soroepidemiologia e pesquisa de riquétsias no sangue de cães e equinos como indicador da circulação de riquétsias na região do Médio Paraibuna, Minas Gerais, Brasil." Universidade Federal de Juiz de Fora, 2014. https://repositorio.ufjf.br/jspui/handle/ufjf/785.
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CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
A Febre Maculosa é uma zoonose causada por bactérias do gênero Rickettsia. A relação natural entre vetores e seus hospedeiros vertebrados, durante o ciclo enzoótico, pode variar no tempo e espaço, evidenciando uma complexidade epidemiológica que deve ser investigada e monitorada como principal indicador para as ações de políticas públicas na prevenção e controle de casos humanos. Nesse aspecto, cães e equinos podem atuar como sentinelas, sinalizando a circulação de riquétsias em uma região, bem como servindo como dispersores de potenciais vetores, permitindo, assim, a amplificação de um foco já estabelecido ou o estabelecimento de novos focos. Com o objetivo de melhor entender a circulação de riquétsia através de pesquisa sorológica no perímetro urbano do município de Juiz de Fora, Minas Gerais, Brasil, considerado área endêmica para febre maculosa, sangue de cães e equinos de diversas regiões foram testados através da Reação de imunofluorescência indireta (RIFI) e Reação em Cadeia da Polimerase (PCR). As amostras resultaram 12,75% (31/243) de cães e 23,68% (9/38) de equinos pela RIFI com títulos ≥ 1:64. Na PCR foram utilizados iniciadores para amplificar fragmentos dos genes gltA e ompA. Nenhum resultado positivo foi encontrado. O maior número de cães positivos ocorreu na região leste da cidade, área com casos humanos descritos entre 2007 e 2008. Entretanto, a maior prevalência e concentração de títulos elevados em cães foi assinalada na região norte, área com casos recentes confirmados (2012), resultado semelhante àquele obtido para equinos, confirmando uma maior atividade dos focos naquela região. Áreas sem caso humano confirmado apresentaram animais com altos títulos, sugerindo um potencial risco para a população. Os resultados confirmam o papel de cães e equinos no ciclo enzoótico de riquétsias na região estudada e seu potencial como indicadores epidemiológicos para a investigação de casos e vigilância de ambiente na febre maculosa.
Spotted Fever is a zoonotic disease caused by bacteria of the genus Rickettsia. The natural relationship between vectors and their vertebrate hosts during the enzootic cycle, may vary in time and space, showing an epidemiological complexity that must be investigated and monitored as a key indicator for the actions of public policy in the prevention and control of human cases. This way, dogs and horses are sentinels, indicating the movement of Rickettsia sp. in a region and serving as dispersers of vectors, allowing the amplification of a focus or establishing new foci. To better understanding of the movement of Rickettsia sp. in the urban area of Juiz de Fora, Minas Gerais, Brazil , endemic area for spotted fever, blood of dogs and horses from different regions were tested by indirect immunofluorescence assay (IFA ) and Polymerase Chain Reaction ( PCR ). Samples resulted 12.75% (31/ 243) of dogs and 23.68 % ( 9/38 ) equine with titers ≥ 1:64. PCR primers were used to amplify fragments of the gltA and ompA genes, no positive results. The highest number of positive dogs occurred in the east region, an area with human cases reported between 2007 and 2008. However, the highest prevalence and concentration of high titers in dogs was reported in the northern region, an area with confirmed recent cases ( 2012 ). Similar results were obtained from equine, confirming a higher activity in the foci of the region. Areas with no human case presented animals with high titers, suggesting a potential risk for the population. The results confirm the role of dogs and horses in the enzootic cycle of Rickettsia in the region studied and its potential as epidemiological indicators for the investigation of cases and monitoring of spotted fever in the environment.
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Rydkina, Elena. "Genotypic analysis of representatives of the order Rickettsiales : application to the epidemiological situation in the former USSR." Aix-Marseille 2, 1999. http://theses.univ-amu.fr.lama.univ-amu.fr/1999AIX20658.pdf.
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Angerami, Rodrigo Nogueira. "Febre maculosa brasileira no estado de São Paulo = aspectos clínicos e epidemiológicos." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310588.
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Orientadores: Luiz Jacintho da Silva, Raquel Silveira Bello StucchiTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Causada pela bactéria Rickettsia rickettsii e transmitida pelos carrapatos Amblyomma cajennense e Amblyomma aureolatum, a febre maculosa brasileira (FMB), após décadas de aparente silêncio epidemiológico, desde sua reemergência nos anos 80, vem figurando como importante problema de saúde pública no estado de São Paulo, sobretudo, em decorrência da aparente expansão das áreas de transmissão e da elevada letalidade a ela associada. O objetivo principal do presente estudo foi descrever características clínicas e epidemiológicas da FMB a partir da análise retrospectiva de casos confirmados da doença em áreas endêmicas no estado de São Paulo. Foi observado que manifestações inespecíficas como febre, cefaléia, mialgia e exantema, foram os sinais clínicos mais freqüentes e precoces. Embora variáveis, elevadas frequências de fenômenos hemorrágicos (22,9%-77,6%), icterícia (16,7%-52%), alterações neurológicas (27,2%-51,7%) e insuficiência respiratória (17,5%-62%) foram observadas. A taxa de letalidade média no estado de São Paulo no período de 2003 a 2008 foi de 29,6%(21,9%-40%). Trombocitopenia e elevação de transaminases hepáticas foram as alterações laboratoriais mais frequentes, ocorrendo em até 100% dos casos. Na faixa etária pediátrica, a FMB também se apresentou como doença severa, associando-se, embora em menor freqüência, às complicações acima mencionadas e à elevada letalidade (28,4%). Entretanto, em estudo comparativo entre o perfil clínico da FMB nos estados de São Paulo e Santa Catarina, observou-se no estado do Sul uma doença com evolução benigna, pequena frequência de sinais de gravidade e ausência de óbitos. Entre pacientes com FMB, as síndromes febris hemorrágica, icterohemorrágica e exantemática foram as mais comumente observadas (37,1%, 33,9%, 11,3%, respectivamente). Dentre os principais diagnósticos diferenciais da FMB, leptospirose, dengue e doença meningocócica foram as mais prevalentes (28,5%, 17,2%, 5,4%, respectivamente). Em 31% dos casos descartados para FMB não foi possível a identificação do diagnóstico etiológico. A doença foi mais incidente no gênero masculino e entre indivíduos da faixa etária de 20 a 49 anos. Em áreas em que o A. cajennense é o principal vetor foi possível observar maior incidência da doença entre o período de Junho a Setembro. Surtos de FMB se associaram a elevadas taxas de letalidade e a diferentes determinantes ecoepidemiológicos. Atividades de lazer e ocupacionais em áreas de mata, pastagem, próximas a coleções hídricas e/ou com presença de animais (cavalos, capivaras e, eventualmente, cães) foram consideradas importantes exposições de risco para infecção. O presente estudo permitiu observar que a infecção pela R. rickettsii no estado de São Paulo se associa à elevada morbimortalidade, sendo, aparentemente, mais severa que a febre das Montanhas Rochosas nos Estados Unidos. Exantema, icterícia e hemorragias são importantes marcadores clínicos que devem ser considerados na suspeição da doença e seus diagnósticos diferencias. O conhecimento das características epidemiológicas e dos fatores de risco para infecção deve fundamentar as ações de prevenção e controle da FMB. A maior severidade da infecção pela R. rickettsii no estado de São Paulo, a ocorrência de casos atípicos em Santa Catarina e a ausência de elucidação diagnóstica em casos descartados para FMB sugerem que cepas de R. rickettsii com distintos padrões de virulência, bem como outras espécies de riquétsias e, eventualmente, outros microorganismos transmitidos por carrapatos devam estar ocorrendo no Brasil
Abstract: Brazilian spotted fever (BSF) is caused by Rickettsia rickettsii and transmited by Amblyomma cajennense and Amblyomma aureolatum ticks. After decades of an apparent epidemiological silence, BSF reemerged as an important public health problem in São Paulo State in the 1980's, mostly because the possible expansion of its transmission areas and the high BSF related fatality-rate. The main objective of the present study was to describe clinical and epidemiological features of BSF through a retrospective analysis of BSF confirmed cases in endemic areas. Non-specific clinical signs like fever, myalgia, headache, and exanthema were the earliest and most frequent clinical signs. A high frequency of hemorrhagic manifestations (22.9%-77.6%), icterus (16.7%-52%), neurological signs (27.2%-51.7%), and respiratory distress (17.5%-62%) was also observed. Case-fatality ratio in São Paulo State between 2003 and 2008 was 29.6% (21.9%-40%). Thrombocytopenia and elevated liver enzymes were the most frequent laboratorial abnormalities, reaching 100% in some groups. In the pediatric age-group, BSF also presented as a severe disease with a slightly lower rate of clinical complications, but a similar high lethality rate (28.4%). Interestingly, when we compared the clinical profile of BSF cases between São Paulo state and Santa Catarina state, located in the southernmost part of Brazil, a milder disease, with a lower frequency of clinical signs of severity and no fatalities was observed in the latter. The most frequent clinical syndromes occurring in BSF patients were hemorrhagic, ictero-hemorrhagic, and exanthematic acute febrile syndromes (37.1%, 33.9% and 11.3% respectively). The most important differential diagnosis to BSF was leptospirosis, dengue fever, and meningococcal disease (28.5%, 17.2%, and 5.4%, respectively). In 31% of non-confirmed BSF cases, no etiological diagnosis was defined. A higher incidence of BSF was observed in males and in the 20-49 years age-group. In areas where A. cajennense is recognized as the most important vector, a higher BSF incidence was observed from June to September. Clusters of BSF were associated to elevated fatality rates and a wide number of ecoepidemiological determinants. Recreational and occupational activities in rural, periurban, and waterside areas, with presence of animals (mostly horses and capybaras, and eventually dogs) were considered the most important exposure risk factors to infection. The present study suggests a more severe pattern of R. rickettsii in São Paulo state when compared with Rocky Mountain spotted fever in United States. Exanthema, icterus, and hemorrhage are important clinical markers of BSF and should be considered in the suspicion of this disease and as a differential diagnosis. Knowledge of clinical, epidemiological, and risk factors for infection should be used to structure and improve the measures for control and prevention of BSF. Together, the higher severity of R. rickettsii infection in São Paulo state, the occurrence of atypical cases in Santa Catarina, and the unknown etiological diagnosis of a high percentage of post-tick exposure febrile patients suggest that more virulent R. rickettsii strains, other Rickttsiae species and, eventually, other tick-borne diseases could be occurring in Brazil
Doutorado
Clinica Medica
Doutor em Clínica Médica
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Socolovschi, Cristina. "Interrelations entre les tiques et les rickettsies." Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX20653.
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Les rickettsies du groupe boutonneux sont considérées comme des pathogènes émergents ou réémergents, transmis pour la plupart par des tiques à travers le monde. Durant les vingt dernières années, 16 nouvelles espèces ou sous espèces de rickettsies ont été caractérisées grâce aux outils épidémiologiques, microbiologiques et moléculaires. De nombreuses inconnues subsistent sur les relations entre les rickettsies et les tiques vectrices ainsi que sur l’éco-épidémiologie des maladies transmises à l’homme. Nous avons utilisé une approche moléculaire pour préciser l’épidémiologie des rickettsioses transmises par les tiques en France, au Maroc, au Tchad, à Djibouti, en Ethiopie, en Ouganda et en Guyane Française. Dans une deuxième partie de nos travaux, nous avons mis en place un protocole d’élevage de tiques, infectées ou non par des rickettsies. Des modèles de Rhipicephalus sanguineus infectés par Rickettsia conorii, Amblyomma variegatum par R. Africae et Dermacentor marginatus par « Rickettsia sp. DmS1 » ont pu ainsi être étudiés. La transmission verticale des rickettsies a été quantifiée. Les points forts de notre travail sont les résultats obtenus sur la relation de Rh. Sanguineus et R. Conorii l’agent pathogène de la fièvre boutonneuse méditerranéenne (FBM) endémique dans les pays du pourtour méditerranéen. Rh. Sanguineus est un vecteur et pourrait aussi jouer le rôle de réservoir de R. Conorii d’après nos résultats. La faible prévalence des tiques trouvées naturellement infectées dans la nature n’est cependant pas expliquée. Nous avons débuté l’étude des facteurs extrinsèques, comme la température sur l’écoépidémiologie de la FBM ainsi que sur les relations Rh. Sanguineus – R. Conorii. Nous avons montré que le réchauffement de la température du milieu environnemental rend ces tiques plus agressives pour l’homme, lors d’une enquête effectuée à Nîmes avec une approche épidémiologique, clinique, microbiologique, entomologique, complétée par des modèles expérimentaux. Le deuxième cas d’infection à R. Massiliae a été rapporté à cette occasion. La température semble être essentielle sur l’écologie et l’épidémiologie des rickettsioses transmises par les tiques et des expérimentations sont en cours pour étudier son influence sur les relations tiques-rickettsiesTick borne rickettsioses have limited geographic distributions that are determined by their tick vectors. During the last 20 years, 16 additional rickettsial species or subspecies were identified and characterized by epidemiologic, microbiological and molecular tools, but there are many unknown questions on the relation between the rickettsiae and their vectors. We used a simple and effective molecular approach to study the epidemiology of the tick borne rickettsioses in France, in Morocco, in Chad, in Djibouti, in Ethiopia, in Uganda and French Guiana. The same approach can be extended to other countries. Three colonies of the naturally infected ticks: Rhipicephalus sanguineus infected with R. Conorii, Amblyomma variegatum infected with R. Africae and Dermacentor marginatus infected with Rickettsia sp. DmS1 and some colonies of not infected ticks were established in the laboratory. Studies of transmission, maintenance, infectivity, virulence, and pathogenicity of tick borne agents require the use of large numbers of live laboratory-raised ticks. A protocol of maintenance of laboratory ticks was established. The vertical transmission of these rickettsiae was studied and these infected ticks could be used to study other aspects of the relations ticks-rickettsiae. One of important point of our work is the results obtained on the relation of Rh. Sanguineus and R. Conorii, agent of the Mediterranean spotted fever (MSF) endemic in the countries of the Mediterranean area. Rh. Sanguineus are not only a vector but could be a reservoir of R. Conorii. A focus of spotted fever was investigated in France in May 2007. In addition to the originality of theses cases (ophthalmic involvements, the second reported case of R. Massiliae infection), we provide evidence that this cluster of cases was related to a warming-mediated increase in the aggressiveness of Rh. Sanguineus, leading to increased human attacks. The temperature seems to be essential on the ecology and the epidemiology of the tick borne rickettsioses. New studies are necessary to better understand the relation between the rickettsies and their vector - ticks
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Fruehwein, Markus. "Diagnostik und Klinik aus Afrika importierter Zeckenbissfieber-Rickettsiosen." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-125829.
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Ngwamidiba, Maxime. "Etude moléculaire des gènes SCA1 et SCA2 codant des protéines autotransporteurs chez les membres du genre " rickettsia"." Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20660.
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Des analyses d'ADN sur les restes des soldats de la Grande Armée de Napoléon (1812) ont révélé la présence entre autre de Rickettsia prowazekii. Pourtant la rickettsiologie ne commençera qu'avec les travaux de Ricketts et von Prowazek en 1910, et ne cessera de s'alimenter d'espèces et de pathologies nouvelles. En tant que premières bactéries intracellulaires strictes décrites, la taxonomie des rickettsies rassemblait initialement sur la base de ce critère, un grand nombre de genres bactériens ultérieurement reclassés avec l'avènement du séquençage et la découverte d'horloges moléculaires telle que la sous-unité 16S de ARN ribosomique ou le cytochrome C. Pour l'identification des espèces de Rickettsia, de nombreux critères phénotypiques dont la morphologie, les tests de fixation du complément, de neutralisation de toxines, de sérotypage et les profils protéiques ont longtemps été utilisés. Mais c'est la comparaison des séquences de gènes, dont ompA, ompB et sca4, qui ont permis d'identifier très précisément les espèces du genre Rickettsia et de proposer une classification phylogénique fiable. Cependant, la position phylogénique d'espèces telles que Rickettsia helvetica, Rickettsia canadensis et Rickettsia bellii n'a pu être déterminée avec certitude. Aussi, l'analyse basée sur la concaténation de plusieurs gènes, associée aux caractères phénotypiques peut constituer une meilleure alternativeThe history of rickettsioses is probably as ancient as human civilisation. The first documented cases of rickettsioses dates back to 1812. In early part of the last century (1910) Ricketts and von Prowazek laid the foundation of modern rickettsiology. Their pioneering works eventually led to the recognition of new species and Rickettsiales infections. As soon as Rickettsia are the first strictly intracellular bacteria described, its taxonomy gathered on the basis of this criterion, and a great number of kinds of bacteria which will be identified only with the advent of the sequencing and the discovery of molecular clocks such as ribosomal 16S RNA and cytochrome C. Many phenotypic criterion such as morphology, tests of complement, neutralization of toxins, mousse serotyping and SDS-page proved reliable. However, gene comparison (ompA, ompB and sca4) will make it possible to very precisely determine the species containing of the genus Rickettsia and to suggest a classification supported by high bootstrap values as well as antibiotics tests. Nevertheless, the phylogenetic position of species such Rickettsia helvetica, Rickettsia canadensis and Rickettsia bellii could not be given with precision, and the polyphasic analysis of the classification of the Rickettsia species based on genes concatenation associated with phenotypic characters available might be alternatives for Rickettsia phylogeny
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Fournier, Pierre-Edouard. "Identification et phylogénie des rickettsies du groupe boutonneux." Aix-Marseille 2, 1999. http://theses.univ-amu.fr.lama.univ-amu.fr/1999AIX20657.pdf.
Full textBooks on the topic "Rickettsiosi"
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E, Hechemy Karim, and New York Academy of Sciences, eds. Century of rickettsiology: Emerging, reemerging rickettsioses, molecular diagnostics, and emerging veterinary rickettsioses. Boston, Mass: Blackwell Pub. on behalf of the New York Academy of Sciences, 2006.
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Řeháček, Josef. Acari-borne rickettsiae & rickettsioses in Eurasia. Bratislava: Veda Publishing House of the Slovak Academy of Sciences, 1988.
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E, Hechemy Karim, and New York Academy of Sciences., eds. Rickettsioses: From genome to proteome, pathobiology, and rickettsiae as an international threat. New York, N.Y: New York Academy of Sciences, 2005.
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Organization, Pan American Health. Zoonosis y enfermedades transmisibles comunes al hombre y a los animales, Volume 2: Volumen 2: Clamidiosis, rickettsiosis, y virosis. 3rd ed. Washington: Pan American Health Organization, 2001.
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Burdmann, Emmanuel A., and Vivekanad Jha. Rickettsiosis. Edited by Vivekanand Jha. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0193.
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Rickettsiae are obligate intracellular bacteria transmitted by arthropods to a vertebrate host. Clinically relevant rickettsioses have a similar clinical pattern, manifesting as an acute febrile disease accompanied by headache, articular and muscle pain, and malaise.Epidemic typhus is a worldwide distributed disease caused by the Rickettsia prowazekii, with a human louse as a vector. Data on epidemic typhus-related renal injury is extremely scarce.Murine typhus is caused by the Rickettsia typhi and has a rodent flea as the vector. It is one of the most frequent rickettsioses, and is usually a self-limited febrile illness. Proteinuria, haematuria, elevations in serum creatinine (SCr) and/or blood urea nitrogen (BUN) and AKI have been reported. The real frequency of renal involvement in murine typhus is unknown. Renal abnormalities recover after the infectious disease resolution.Scrub typhus, caused by the Orientia tsutsugamushi, has the Leptotrombidium mite larva as vector. It is endemic in the Tsutsugamushi triangle delimited by Japan, Australia, India, and Siberia. It can manifest either as a self-limiting disease or as a severe, life-threatening multiorgan illness. Early administration of adequate antibiotics is essential to prevent adverse outcomes. Proteinuria, haematuria, and acute kidney injury (AKI) are frequent.Tick-borne rickettsioses are caused by bacteria from the spotted fever group and have ticks as vectors. Rocky Mountain spotted fever (RMSF) is caused by Rickettsia rickettsii. It is the most severe of the spotted fever rickettsial diseases, causing significant morbidity and lethality. RMSF occurs in North, Central, and South America. Renal impairment is frequent in severe forms of RMSF. Mediterranean spotted fever is caused by Rickettsia conorii, and is endemic in the Mediterranean area. It is usually a benign disease, but may have a severe course, clinically similar to RMSF. Haematuria, proteinuria, increased serum creatinine, and AKI may occur. Japanese spotted fever is caused by Rickettsia japonica. Lethal cases are reported yearly and AKI has occurred in the context of multiple organ failure.
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Mohr, Werner, Egbert Asshauer, and Otto Gsell. Rickettsiosen und Protozoenkrankheiten. Springer, 2013.
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Blanco, José R. Century of Rickettsiology: Emerging, Reemerging Rickettsioses, Molecular Diagnostics, and Emerging Veterinary Rickettsioses (Annals of the New York Academy of Sciences). Blackwell Publishing Limited, 2006.
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Nasemann, T., Theodor Nasemann, and Alfred Marchionini. Die Viruskrankheiten der Haut: Und Die Hautsymptome Bei Rickettsiosen und Bartonellosen. Springer, 2012.
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Nasemann, T., Theodor Nasemann, and Alfred Marchionini. Die Viruskrankheiten der Haut: Und Die Hautsymptome Bei Rickettsiosen und Bartonellosen. Springer London, Limited, 2013.
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Nathan, Neil, writer of foreword, ed. Healing Lyme: Natural healing of Lyme borreliosis and the coinfections chlamydia and spotted fever rickettsioses. 2015.
Find full textBook chapters on the topic "Rickettsiosi"
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Khochtali, Sana, Sonia Attia, and Moncef Khairallah. "Rickettsioses." In Emerging Infectious Uveitis, 27–34. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-23416-8_3.
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Rovery, Clarisse, and Didier Raoult. "Rickettsioses." In Manifestations dermatologiques des maladies infectieuses, métaboliques et toxiques, 38–48. Paris: Springer Paris, 2008. http://dx.doi.org/10.1007/978-2-287-48494-0_5.
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Kager, Piet A., and Hans G. Schipper. "Rickettsioses." In Imported Skin Diseases, 114–22. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118472620.ch11.
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Löscher, T. "Rickettsiosen." In Therapie innerer Krankheiten, 1152–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-662-10479-8_86.
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Löscher, T. "Rickettsiosen." In Therapie innerer Krankheiten, 932–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-662-10481-1_87.
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Löscher, T. "Rickettsiosen." In Therapie innerer Krankheiten, 782–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-662-10483-5_86.
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Lancaster, H. O. "Rickettsioses." In Expectations of Life, 160–64. New York, NY: Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4612-1003-0_14.
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Fleischer, Bernhard, and Christian A. Keller. "Rickettsiosen." In Reisedermatosen, 57–62. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44705-5_14.
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Gooch, Jan W. "Rickettsias." In Encyclopedic Dictionary of Polymers, 921. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_14713.
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Maina, Alice N., Stephanie Speck, Eva Spitalska, Rudolf Toman, Gerhard Dobler, and Sally J. Cutler. "RickettsiaSpecies: Rickettsioses." In BSL3 and BSL4 Agents, 318–21. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527645114.ch22.
Full textConference papers on the topic "Rickettsiosi"
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Chekanova, T. A. "LABORATORY CONFIRMATION OF THE SPOTTED FEVER GROUP RICKETTSIOSES AMONG PATIENTS WITH TYPICAL AND ATYPICAL CLINICAL MANIFESTATIONS." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-81.
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In the group of patients with typical clinical signs of acute tick-borne rickettsioses, specific IgM and/or IgG with/without IgA were found in 75.6% cases. IgG were low avidity in most cases, which indicated the recent primary infection. More than 20% of sera have single group specific IgA. In patients with atypical manifestations highly avidity IgG were predominant, that along with the presence of IgM and/or IgA may indicate re-infection or infection by new species, which is different from previous pathogen of the tick-borne spotted group rickettsioses.
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EUGENIO, MIRIÃ BRAZ DUARTE, and THIARLES CRISTIAN APARECIDO TONON. "AS FRAGILIDADES DA FEBRE MACULOSA BRASILEIRA (RICKETTSIAS)." In II Congresso Brasileiro de Saúde Pública On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrasp/12740.
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Luraschi-Monjagatta, CARMEN, and Linda Snyder. "A Case Of Rickettsia Rickettsii Infection And ARDS In Arizona." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6453.
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Swaney, R., and M. Velagapudi. "Drug and a Tick- A Rare Case of Drug Induced Hemolytic Anemia in a Patient with Spotted Fever Rickettsiosis." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1573.
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Levin, Michael L. "Comparison of US Amblyomma,Dermacentor, and Rhipicephalus ticks in their ability to transmit R. rickettsii." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.103182.
Full textReports on the topic "Rickettsiosi"
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Walker, David H., and Juan P. Olano. Molecular Pathogenesis of Rickettsioses and Development of Novel Anti-Rickettsia Treatment by Comginatorial Peptide-Based Libraries. Fort Belvoir, VA: Defense Technical Information Center, February 2005. http://dx.doi.org/10.21236/ada442166.
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