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Journal articles on the topic 'Rifampicin‐resistant Mutants'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Al- Khafaji, K. A., and A. N. Al- Thwami. "Identification of differences in virulence factors production from mutant isolates of clinical Vibrio cholerae S." Journal of Biotechnology Research Center 5, no. 1 (2011): 61–73. http://dx.doi.org/10.24126/jobrc.2011.5.1.149.

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Antibiotic resistant mutants for rifampicin, streptomycin and klindamycin were isolated from the clinical isolate of Vibrio choleraeS mutated by chemical mutagens. Mutation frequency of V. cholerae S depends on the treatment time and the highest viable count of antibiotic resistant were for Rifampicin after treatment with Acridine orange, Ethedium bromide, Nitrosoguanidine, 5-Florouracil, 2-Bromouracil and cyclophosphamide. One thousand mutant isolates were examined for morphological differences in colony surface, color and diameter. The treatment with AO, NTG, 5-FU, and 2-BU gave opaque to or

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Ostash, B. O., Yu Misaki, B. S. Dolya, et al. "Generation and initial characterization of a collection of spontaneous Streptomyces albus J1074 mutants resistant to rifampicin." Faktori eksperimental'noi evolucii organizmiv 27 (September 1, 2020): 139–43. http://dx.doi.org/10.7124/feeo.v27.1316.

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Aim. Streptomyces albus J1074 is one of the most popular streptomycete chassis for heterologous expression of natural product (NP) biosynthetic gene clusters (BGCs). There is keen interest in further improvement of the strain to provide increased yields of corresponding NPs. Introduction of certain types of antibiotic resistance mutations is a proven way to improve Streptomyces strains. For example, selection for increased resistance to rifampicin is known to lead to increased antibiotic activity. Here we used available lineages of antibiotic-resistant mutants of S. albus to raise rifampicin-r

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Luz, Bruno T. S., João S. Rebelo, Francisca Monteiro, and Francisco Dionisio. "What Is the Impact of Antibiotic Resistance Determinants on the Bacterial Death Rate?" Antibiotics 14, no. 2 (2025): 201. https://doi.org/10.3390/antibiotics14020201.

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Objectives: Antibiotic-resistant bacteria are widespread, with resistance arising from chromosomal mutations and resistance genes located in the chromosome or in mobile genetic elements. While resistance determinants often reduce bacterial growth rates, their influence on bacterial death under bactericidal antibiotics remains poorly understood. When bacteria are exposed to bactericidal antibiotics to which they are susceptible, they typically undergo a two-phase decline: a fast initial exponentially decaying phase, followed by a persistent slow-decaying phase. This study examined how resistanc

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Jin, Ding Jun, William A. Walter, and Carol A. Gross. "Characterization of the termination phenotypes of rifampicin-resistant mutants." Journal of Molecular Biology 202, no. 2 (1988): 245–53. http://dx.doi.org/10.1016/0022-2836(88)90455-x.

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Lee, D. H., R. J. Miles, and J. R. M. Inal. "Antibiotic sensitivity and mutation rates to antibiotic resistance inMycoplasma mycoidesssp.mycoides." Epidemiology and Infection 98, no. 3 (1987): 361–68. http://dx.doi.org/10.1017/s0950268800062129.

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SUMMARYThe antibiotic resistance ofMycoplasma mycoidesssp.mycoidesstrain T1was investigated. This strain was resistant to high levels ( > 100 μg ml−1) of rifampicin and nalidixic acid. It was sensitive to streptomycin, spectinomycin and novobiocin; however, single step mutants with high levels of resistance ( > 100 μg ml−1) were readily isolated. With erythromycin and tylosin for which the minimum inhibitory concentration (MIC) for the parent strain was < 0·1 μg ml−1, mutants resistant to > 100 μg ml−1were obtained in two and three steps respectively. The MIC of tetracycline in sin

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Do, Thi Thuy, Jerónimo Rodríguez-Beltran, Esmeralda Cebrián-Sastre, Alexandro Rodríguez-Rojas, Alfredo Castañeda-García, and Jesús Blázquez. "Inactivation of a New Potassium Channel Increases Rifampicin Resistance and Induces Collateral Sensitivity to Hydrophilic Antibiotics in Mycobacterium smegmatis." Antibiotics 11, no. 4 (2022): 509. http://dx.doi.org/10.3390/antibiotics11040509.

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Rifampicin is a critical first-line antibiotic for treating mycobacterial infections such as tuberculosis, one of the most serious infectious diseases worldwide. Rifampicin resistance in mycobacteria is mainly caused by mutations in the rpoB gene; however, some rifampicin-resistant strains showed no rpoB mutations. Therefore, alternative mechanisms must explain this resistance in mycobacteria. In this work, a library of 11,000 Mycobacterium smegmatis mc2 155 insertion mutants was explored to search and characterize new rifampicin-resistance determinants. A transposon insertion in the MSMEG_194

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Bhatnagar, N., E. Getachew, S. Straley, J. Williams, M. Meltzer, and A. Fortier. "Reduced Virulence Of Rifampicin-Resistant Mutants Of Francisella Tularensis [X]." Journal of Infectious Diseases 170, no. 4 (1994): 841–47. http://dx.doi.org/10.1093/infdis/170.4.841.

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8

Rodriguez, Carlos Hernan, Alejandra De Ambrosio, Milena Bajuk, et al. "In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones." Journal of Infection in Developing Countries 4, no. 03 (2010): 164–67. http://dx.doi.org/10.3855/jidc.604.

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Background: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance. Methodology: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance

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Severinov, K., M. Soushko, A. Goldfarb, and V. Nikiforov. "Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase." Journal of Biological Chemistry 268, no. 20 (1993): 14820–25. http://dx.doi.org/10.1016/s0021-9258(18)82407-3.

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Silvia, Sophia, Samantha A. Donahue, Erin E. Killeavy, Gerwald Jogl, and Steven T. Gregory. "A Survey of Spontaneous Antibiotic-Resistant Mutants of the Halophilic, Thermophilic Bacterium Rhodothermus marinus." Antibiotics 10, no. 11 (2021): 1384. http://dx.doi.org/10.3390/antibiotics10111384.

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Rhodothermus marinus is a halophilic extreme thermophile, with potential as a model organism for studies of the structural basis of antibiotic resistance. In order to facilitate genetic studies of this organism, we have surveyed the antibiotic sensitivity spectrum of R. marinus and identified spontaneous antibiotic-resistant mutants. R. marinus is naturally insensitive to aminoglycosides, aminocylitols and tuberactinomycins that target the 30S ribosomal subunit, but is sensitive to all 50S ribosomal subunit-targeting antibiotics examined, including macrolides, lincosamides, streptogramin B, ch

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von Freiesleben, Ulrik, Knud V. Rasmussen, Tove Atlung, and Flemming G. Hansen. "Rifampicin-resistant initiation of chromosome replication from oriC in ihf mutants." Molecular Microbiology 37, no. 5 (2000): 1087–93. http://dx.doi.org/10.1046/j.1365-2958.2000.02060.x.

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Amusengeri, Arnold, Asifullah Khan, and Özlem Tastan Bishop. "The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding." Molecules 27, no. 3 (2022): 885. http://dx.doi.org/10.3390/molecules27030885.

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Tuberculosis (TB), caused by the Mycobacterium tuberculosis infection, continues to be a leading cause of morbidity and mortality in developing countries. Resistance to the first-line anti-TB drugs, isoniazid (INH) and rifampicin (RIF), is a major drawback to effective TB treatment. Genetic mutations in the β-subunit of the DNA-directed RNA polymerase (rpoB) are reported to be a major reason of RIF resistance. However, the structural basis and mechanisms of these resistant mutations are insufficiently understood. In the present study, thirty drug-resistant mutants of rpoB were initially modele

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Widanarni, D. Meha, Sri Nuryati, Sukenda, and A. Suwanto. "Pathogenicity Assay of Vibrio harveyi in Tiger Shrimp Larvae Employing Rifampicin-Resistant as A Molecular Marker." Jurnal Akuakultur Indonesia 3, no. 3 (2007): 23. http://dx.doi.org/10.19027/jai.3.23-27.

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<p>Rifampicin-resistant marker was employed as a reporter to assay pathogenicity of <em>Vibrio harveyi</em> in shrimp larvae. <em>V. harveyi</em> M. G<sub>3</sub> and G<sub>7</sub> that difference not schizotyping as shown by Pulsed-Filed Gel Electrophoresis (PFGE) used in this study. Spontaneous mutation was conducted to generate <em>V. harveyi</em> resistant to rifampicin. Two groups of shrimp post-larvae (PL<sub>5</sub>) were immersed for 30 min in 106 CFU/ml of mutants and wild type of <em>V. harveyi</em

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Malshetty, Vidyasagar, Krishna Kurthkoti, Arnab China, et al. "Novel insertion and deletion mutants of RpoB that render Mycobacterium smegmatis RNA polymerase resistant to rifampicin-mediated inhibition of transcription." Microbiology 156, no. 5 (2010): 1565–73. http://dx.doi.org/10.1099/mic.0.036970-0.

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The startling increase in the occurrence of rifampicin (Rif) resistance in the clinical isolates of Mycobacterium tuberculosis worldwide is posing a serious concern to tuberculosis management. The majority of Rif resistance in bacteria arises from mutations in the RpoB subunit of the RNA polymerase. We isolated M. smegmatis strains harbouring either an insertion (6 aa) or a deletion (10 aa) in their RpoB proteins. Although these strains showed a compromised fitness for growth in 7H9 Middlebrook medium, their resistance to Rif was remarkably high. The attenuated growth of the strains correlated

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Dolya, Borys, Olena Hryhorieva, Khrystyna Sorochynska, et al. "Properties of Multidrug-Resistant Mutants Derived from Heterologous Expression Chassis Strain Streptomyces albidoflavus J1074." Microorganisms 11, no. 5 (2023): 1176. http://dx.doi.org/10.3390/microorganisms11051176.

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Streptomyces albidoflavus J1074 is a popular platform to discover novel natural products via the expression of heterologous biosynthetic gene clusters (BGCs). There is keen interest in improving the ability of this platform to overexpress BGCs and, consequently, enable the purification of specialized metabolites. Mutations within gene rpoB for the β-subunit of RNA polymerase are known to increase rifampicin resistance and augment the metabolic capabilities of streptomycetes. Yet, the effects of rpoB mutations on J1074 remained unstudied, and we decided to address this issue. A target collectio

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Vilchèze, Catherine, Travis Hartman, Brian Weinrick, et al. "Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis." Proceedings of the National Academy of Sciences 114, no. 17 (2017): 4495–500. http://dx.doi.org/10.1073/pnas.1704376114.

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Persistence, manifested as drug tolerance, represents a significant obstacle to global tuberculosis control. The bactericidal drugs isoniazid and rifampicin kill greater than 99% of exponentially growing Mycobacterium tuberculosis (Mtb) cells, but the remaining cells are persisters, cells with decreased metabolic rate, refractory to killing by these drugs, and able to generate drug-resistant mutants. We discovered that the combination of cysteine or other small thiols with either isoniazid or rifampicin prevents the formation of drug-tolerant and drug-resistant cells in Mtb cultures. This effe

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Tóth, I., Márta Csík, and L. Emçdy. "Spontaneous antibiotic resistance mutation associated pleiotropic changes in Escherichia coli O157:H7." Acta Veterinaria Hungarica 51, no. 1 (2003): 29–44. http://dx.doi.org/10.1556/avet.51.2003.1.3.

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Besides the well-known O157:H7 clone causing enterohaemorrhagic colitis and haemolytic uraemic syndrome in Europe, Japan and North America, the number of Escherichia coli isolates with non-motile (NM) phenotype has considerably increased. We supposed that spontaneous antibiotic resistance mutation could cause this phenotypic change. To model our hypothesis we isolated rifampicin- (Rif) and ampicillin- (Amp) resistant mutants from E. coli O157:H7 prototype strains 7785 and EDL933. Among Rif r mutants we could isolate strains with no or reduced motility, while the Ampr mutants became hypermotile

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Olambe, Tejaswini A., Pooja G. Shah, Sae Pol, Vaishali Gaikwad, Bhakti Karmalkar, and Rajesh Karyakarte. "Detection of Resistant Prevalent Genes for Mycobacterium Tuberculosis by Line Probe Assay." Medical Journal of Dr. D.Y. Patil Vidyapeeth 18, no. 2 (2025): 299–304. https://doi.org/10.4103/mjdrdypu.mjdrdypu_308_24.

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ABSTRACT Background: The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains especially MDR-TB and indeed XDR-TB is a real threat to achieving TB control. Rapid diagnosis of mutations in drug-resistant strains has vital importance in the prognosis. The aim was to identify mutations responsible for drug resistance in Mtb strains derived from patients with tuberculosis using the line probe assay (LPA) method. Materials and Methods: Samples from 191 pulmonary and extrapulmonary Mtb-positive patients by GeneXpert-CBNAAT were collected in 50 ml sterile Falcon tube from MDR-TB suspe

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Liu, Liping, Hanne Ingmer, and Martin Vestergaard. "Genome-Wide Identification of Resveratrol Intrinsic Resistance Determinants in Staphylococcus aureus." Antibiotics 10, no. 1 (2021): 82. http://dx.doi.org/10.3390/antibiotics10010082.

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Resveratrol has been extensively studied due to its potential health benefits in multiple diseases, for example, cancer, obesity and cardiovascular diseases. Besides these properties, resveratrol displays inhibitory activity against a wide range of bacterial species; however, the cellular effects of resveratrol in bacteria remain incompletely understood, especially in the human pathogen, Staphylococcus aureus. In this study, we aimed to identify intrinsic resistance genes that aid S. aureus in tolerating the activity of resveratrol. We screened the Nebraska Transposon Mutant Library, consistin

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Safi, Hassan, Robert D. Fleischmann, Scott N. Peterson, Marcus B. Jones, Behnam Jarrahi, and David Alland. "Allelic Exchange and Mutant Selection Demonstrate that Common Clinical embCAB Gene Mutations Only Modestly Increase Resistance to Ethambutol in Mycobacterium tuberculosis." Antimicrobial Agents and Chemotherapy 54, no. 1 (2009): 103–8. http://dx.doi.org/10.1128/aac.01288-09.

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ABSTRACT Mutations within codon 306 of the Mycobacterium tuberculosis embB gene modestly increase ethambutol (EMB) MICs. To identify other causes of EMB resistance and to identify causes of high-level resistance, we generated EMB-resistant M. tuberculosis isolates in vitro and performed allelic exchange studies of embB codon 406 (embB406) and embB497 mutations. In vitro selection produced mutations already identified clinically in embB306, embB397, embB497, embB1024, and embC13, which result in EMB MICs of 8 or 14 μg/ml, 5 μg/ml, 12 μg/ml, 3 μg/ml, and 4 μg/ml, respectively, and mutations at e

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Monama, Mokgerwa Zacharia, Fisayo Olotu, and Özlem Tastan Bishop. "Investigation of Multi-Subunit Mycobacterium tuberculosis DNA-Directed RNA Polymerase and Its Rifampicin Resistant Mutants." International Journal of Molecular Sciences 24, no. 4 (2023): 3313. http://dx.doi.org/10.3390/ijms24043313.

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Emerging Mycobacterium tuberculosis (Mtb) resistant strains have continued to limit the efficacies of existing antitubercular therapies. More specifically, mutations in the RNA replicative machinery of Mtb, RNA polymerase (RNAP), have been widely linked to rifampicin (RIF) resistance, which has led to therapeutic failures in many clinical cases. Moreover, elusive details on the underlying mechanisms of RIF-resistance caused by Mtb-RNAP mutations have hampered the development of new and efficient drugs that are able to overcome this challenge. Therefore, in this study we attempt to resolve the

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Bayliss, Cathy, Bonnie Lasby, Janet M. Wood, Ran Lifshitz, and Gerry L. Brown. "Mutant derivatives of Pseudomonas putida GR12-2R3 defective in nutrient utilization or cell surface structures show reduced ability to promote canola root elongation." Canadian Journal of Microbiology 39, no. 12 (1993): 1111–19. http://dx.doi.org/10.1139/m93-168.

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Pseudomonas putida GR12-2R3 is a rifampicin-resistant derivative of a cold-tolerant, nitrogen-fixing bacterium isolated from the roots of grasses growing in the Canadian high arctic. It colonizes canola (Brassica campestris) roots and promotes canola root and shoot growth under gnotobiotic conditions and in the field. TnphoA insertion mutagenesis was used to isolate derivatives of strain GR12-2R3 that had reduced abilities to promote canola root elongation (PRE− mutants). Within a pool of 10 290 TnphoA insertion mutants, 1.4% expressed active PhoA fusion proteins (PhoA+). Among 20 PhoA+ mutant

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Cuella-Martin, Isabel, Jean Claude Semuto Ngabonziza, Gabriela Torrea, et al. "Rifampicin Resistance Conferring Mutations among Mycobacterium tuberculosis Strains in Rwanda." International Journal of Mycobacteriology 12, no. 3 (2023): 274–81. https://doi.org/10.4103/ijmy.ijmy_103_23.

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Abstract Background: The World Health Organization-endorsed phenotypic and genotypic drug-susceptibility testing (gDST/pDST) assays for the detection of rifampicin-resistant (RR) tuberculosis (TB), may miss some clinically relevant rpoB mutants, including borderline mutations and mutations outside the gDST-targeted hotspot region. Sequencing of the full rpoB gene is considered the reference standard for rifampicin DST but is rarely available in RR-TB endemic settings and when done indirectly on cultured isolates may not represent the full spectrum of mutations. Hence, in most such settings, th

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Journal, Baghdad Science. "Developing of Bacterial Mutagenic Assay System for Detection of Environmental and Food MutagensV – Using Anticancer Drug Cyclophosphamide." Baghdad Science Journal 5, no. 4 (2008): 500–512. http://dx.doi.org/10.21123/bsj.5.4.500-512.

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G-system composed of three isolates G3 ( Bacillus),G12 ( Arthrobacter )and G27 ( Brevibacterium) was used to detect the mutagenicity of the anticancer drug, cyclophosphamide (CP) under conditions similar to that used for standard mutagen, Nitrosoguanidine (NTG). The CP effected the survival fraction of isolates after treatment for 15 mins using gradual increasing concentrations, but at less extent comparing to NTG. The mutagenic effect of CP was at higher level than that of NTG when using streptomycin as a genetic marker, but the situation was reversed when using rifampicin resistant as a repo

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Al-Khafaji, Zahra M., Elham A. Kalaf, and Gaith L. Al-Azawi. "Developing of Bacterial Mutagenic Assay System for Detection of Environmental and Food MutagensV – Using Anticancer Drug Cyclophosphamide." Baghdad Science Journal 5, no. 4 (2008): 500–512. http://dx.doi.org/10.21123/bsj.2008.5.4.500-512.

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G-system composed of three isolates G3 ( Bacillus),G12 ( Arthrobacter )and G27 ( Brevibacterium) was used to detect the mutagenicity of the anticancer drug, cyclophosphamide (CP) under conditions similar to that used for standard mutagen, Nitrosoguanidine (NTG). The CP effected the survival fraction of isolates after treatment for 15 mins using gradual increasing concentrations, but at less extent comparing to NTG. The mutagenic effect of CP was at higher level than that of NTG when using streptomycin as a genetic marker, but the situation was reversed when using rifampicin resistant as a repo

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Qi, Qin, Macarena Toll-Riera, Karl Heilbron, Gail M. Preston, and R. Craig MacLean. "The genomic basis of adaptation to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa." Proceedings of the Royal Society B: Biological Sciences 283, no. 1822 (2016): 20152452. http://dx.doi.org/10.1098/rspb.2015.2452.

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Antibiotic resistance carries a fitness cost that must be overcome in order for resistance to persist over the long term. Compensatory mutations that recover the functional defects associated with resistance mutations have been argued to play a key role in overcoming the cost of resistance, but compensatory mutations are expected to be rare relative to generally beneficial mutations that increase fitness, irrespective of antibiotic resistance. Given this asymmetry, population genetics theory predicts that populations should adapt by compensatory mutations when the cost of resistance is large,

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Jeon, Se-Mi, Sanghee Park, Na-Ra Lim, et al. "Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea." Antibiotics 12, no. 8 (2023): 1324. http://dx.doi.org/10.3390/antibiotics12081324.

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Rapid and accurate detection of tuberculosis (TB) drug resistance is critical for the successful treatment and control of TB. Here, we investigated resistance to anti-TB drugs and genetic variations in 215 drug-resistant Mycobacterium tuberculosis isolates in Korea. Genetic variations were observed in rpoB Ser531Leu, katG Ser315Thr, and gyrA Asp94Gly; however, the minimum inhibitory concentrations varied, which can be attributed to other resistance mechanisms. Examination of genetic relatedness among drug-resistant isolates revealed that the cluster size of resistant bacteria was less than six

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Al-Ani, B., M. Aboshkiwa, R. E. Glass, and G. Coleman. "The patterns of extracellular protein formation by spontaneously-occurring rifampicin-resistant mutants ofStaphylococcus aureus." FEMS Microbiology Letters 70, no. 1 (1990): 91–94. http://dx.doi.org/10.1111/j.1574-6968.1990.tb03782.x.

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Dixit, Anupam, and Devindra Vijay Amla. "Studies on two classes of rifampicin-resistant mutants of the nitrogen-fixing cyanobacteriumNostoc muscorum." Current Microbiology 18, no. 3 (1989): 157–64. http://dx.doi.org/10.1007/bf01569564.

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Olivares-Fuster, O., and C. R. Arias. "Development and characterization of rifampicin-resistant mutants from high virulent strains of Flavobacterium columnare." Journal of Fish Diseases 34, no. 5 (2011): 385–94. http://dx.doi.org/10.1111/j.1365-2761.2011.01253.x.

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García de Salamone, Ines E., Russell K. Hynes, and Louise M. Nelson. "Cytokinin production by plant growth promoting rhizobacteria and selected mutants." Canadian Journal of Microbiology 47, no. 5 (2001): 404–11. http://dx.doi.org/10.1139/w01-029.

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One of the proposed mechanisms by which rhizobacteria enhance plant growth is through the production of plant growth regulators. Five plant growth promoting rhizobacterial (PGPR) strains produced the cytokinin dihydrozeatin riboside (DHZR) in pure culture. Cytokinin production by Pseudomonas fluorescens G2018, a rifampicin-resistant mutant (RIF), and two TnphoA-derived mutants (CNT1, CNT2), with reduced capacity to synthesize cytokinins, was further characterized in pure culture using immunoassay and thin layer chromatography. G2018 produced higher amounts of three cytokinins, isopentenyl ad

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Baldwin, Susan L., Sasha E. Larsen, Valerie A. Reese, et al. "Use of GLA-nanoalum as an effective adjuvant for a therapeutic ID93 TB vaccine." Journal of Immunology 200, no. 1_Supplement (2018): 180.21. http://dx.doi.org/10.4049/jimmunol.200.supp.180.21.

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Abstract Tuberculosis (TB) caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb) reportedly killed 1.3 million people in 2016 and is the leading cause of death caused by a single infectious organism. Increasingly worrisome is the ability of Mtb to develop extensive drug resistance. According to the 2017 WHO global TB report, there were 600,000 new rifampicin-resistant cases in 2016, and almost half a million cases with multiple drug resistant (MDR) TB. The development of new host-targeted therapeutic strategies that prevent the outgrowth of resistant mutants and/or modulate th

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Laycock, Phillip, John Cooper, Robert Howlin, Craig Delury, Sean Aiken, and Paul Stoodley. "In Vitro Efficacy of Antibiotics Released from Calcium Sulfate Bone Void Filler Beads." Materials 11, no. 11 (2018): 2265. http://dx.doi.org/10.3390/ma11112265.

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15 different antibiotics were individually mixed with commercially available calcium sulfate bone void filler beads. The antibiotics were: amikacin, ceftriaxone, cefuroxime, ciprofloxacin, clindamycin, colistamethate sodium, daptomycin, gentamicin, imipenem/cilastatin, meropenem, nafcillin, rifampicin, teicoplanin, tobramycin and vancomycin. The efficacy of specific released antibiotics was validated by zone of inhibition (ZOI) testing using a modified Kirby–Bauer disk diffusion method against common periprosthetic joint infection pathogens. With a subset of experiments (daptomycin, rifampin,

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Liu, Anne, Lillian Tran, Elinne Becket, et al. "Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code." Antimicrobial Agents and Chemotherapy 54, no. 4 (2010): 1393–403. http://dx.doi.org/10.1128/aac.00906-09.

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ABSTRACT We have defined a sensitivity profile for 22 antibiotics by extending previous work testing the entire KEIO collection of close to 4,000 single-gene knockouts in Escherichia coli for increased susceptibility to 1 of 14 different antibiotics (ciprofloxacin, rifampin [rifampicin], vancomycin, ampicillin, sulfamethoxazole, gentamicin, metronidazole, streptomycin, fusidic acid, tetracycline, chloramphenicol, nitrofurantoin, erythromycin, and triclosan). We screened one or more subinhibitory concentrations of each antibiotic, generating more than 80,000 data points and allowing a reduction

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Keleshyan, Susanna, Zhaneta Karapetyan, Anna Toplaghaltsyan, et al. "Antibiotic-resistant mutants of lactic acid bacteria: potential food control agents." Bioactive Compounds in Health and Disease - Online ISSN: 2574-0334; Print ISSN: 2769-2426 7, no. 9 (2024): 430–43. http://dx.doi.org/10.31989/bchd.v7i9.1424.

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Background: One of the most pressing challenges facing global agriculture today is the restoration of degraded farmland. Organic fertilisers are increasingly being used as a safer alternative to synthetic forms. The most promising form of environmentally friendly fertiliser is a bioconsortium based on different groups of microorganisms. Lactic acid bacteria (LAB) with high antifungal activity, isolated from Armenian dairy products, can form part of such a bioconsortium and protect plants from phytopathogens. In addition, LAB can be used as a preservative in the food industry due to its GRAS (g

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Kim, Hyung Soo, Fung Chil Choi, and Byong Kak Kim. "Studies on development of resistant strains to antibiotics and antituberculosis agents(II) isolation of rifampicin resistant mutants fromClostridium butyricum." Archives of Pharmacal Research 11, no. 3 (1988): 218–24. http://dx.doi.org/10.1007/bf02861312.

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Hansen, Flemming G. "Reinitiation kinetics in eight dnaA(Ts) mutants of Escherichia coli: rifampicin-resistant Initiation of chromosome replication." Molecular Microbiology 15, no. 1 (1995): 133–40. http://dx.doi.org/10.1111/j.1365-2958.1995.tb02227.x.

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Yu, Jun, Jenny Wu, Kevin P. Francis, Tony F. Purchio, and Jagath L. Kadurugamuwa. "Monitoring in vivo fitness of rifampicin-resistant Staphylococcus aureus mutants in a mouse biofilm infection model." Journal of Antimicrobial Chemotherapy 55, no. 4 (2005): 528–34. http://dx.doi.org/10.1093/jac/dki053.

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Carata, Elisabetta, Clelia Peano, Salvatore M. Tredici, et al. "Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production." Microbial Cell Factories 8, no. 1 (2009): 18. http://dx.doi.org/10.1186/1475-2859-8-18.

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Briggs, Robert E., Glynn H. Frank, and Emilie S. Zehr. "Development and testing of a unique strain of Pasteurella haemolytica for use in studies on colonization of the respiratory tract of cattle." American Journal of Veterinary Research 59, no. 4 (1998): 426–30. http://dx.doi.org/10.2460/ajvr.1998.59.04.426.

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Abstract Objective To develop a unique strain of Pasteurella haemolytica, selectable from nasopharyngeal respiratory tract secretions, that retains the ability to efficiently colonize the respiratory tract of calves. Animals 26 calves that each weighed approximately 200 kg. Procedure Rifampicin-resistant mutants of P haemolytica were developed and tested for in vitro growth rate and leukotoxin production. After instillation into the tonsils of calves, an isolate that was efficient at colonizing was selected and transformed, using electroporation, with a 4.2-kilobase (kb) plasmid encoding for s

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A. Khalaf, Ilham. "ANTIMUTAGENIC EFFECT OF CARROT (Daucus carota) ON INDUCTION OF STREPTOMYCIN AND RIFAMPICIN RESISTANT MUTANTS IN BACTERIAL SYSTEMS." Mesopotamia Journal of Agriculture 36, no. 3 (2008): 94–104. http://dx.doi.org/10.33899/magrj.2008.26765.

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A. Khalaf, Ilham. "ANTIMUTAGENIC EFFECT OF ROCKET (Eruca sativa ) ON INDUCTION OF STREPTOMYCIN AND RIFAMPICIN RESISTANT MUTANTS IN BACTERIAL SYSTEMS." Mesopotamia Journal of Agriculture 36, no. 4 (2008): 139–94. http://dx.doi.org/10.33899/magrj.2008.27069.

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A. Khalaf, Ilham. "ANTIMUTAGENIC EFFECT OF ROCKET (Eruca sativa ) ON INDUCTION OF STREPTOMYCIN AND RIFAMPICIN RESISTANT MUTANTS IN BACTERIAL SYSTEMS." Mesopotamia Journal of Agriculture 36, no. 4 (2008): 139–49. http://dx.doi.org/10.33899/magrj.2008.27317.

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Vlková, E., M. Grmanová, V. Rada, I. Homutová, and S. Dubná. "Selection of probiotic bifidobacteria for lambs." Czech Journal of Animal Science 54, No. 12 (2009): 552–65. http://dx.doi.org/10.17221/151/2009-cjas.

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Twenty-six bifidobacteria were isolated from faecal samples of lambs. The isolates were identified, functional properties (survival ability at low pH and bile conditions) and antimicrobial activities against potential pathogens were determined. From the isolates with suitable properties (13 strains) rifampicin-resistant mutants were prepared by gradient plate techniques. This property enabled us to differentiate the administered organism from wild strains because resistance to rifampicin is rare among bifidobacteria. Rifampicin-resistant bifidobacteria (RRBifs) were administered to 3-days-old

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Margaret, Isabel, Juan C. Crespo-Rivas, Sebastián Acosta-Jurado, et al. "Sinorhizobium fredii HH103 rkp-3 Genes Are Required for K-Antigen Polysaccharide Biosynthesis, Affect Lipopolysaccharide Structure and Are Essential for Infection of Legumes Forming Determinate Nodules." Molecular Plant-Microbe Interactions® 25, no. 6 (2012): 825–38. http://dx.doi.org/10.1094/mpmi-10-11-0262.

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The Sinorhizobium fredii HH103 rkp-3 region has been isolated and sequenced. Based on the similarities between the S. fredii HH103 rkpL, rkpM, rkpN, rkpO, rkpP, and rkpQ genes and their corresponding orthologues in Helicobacter pylori, we propose a possible pathway for the biosynthesis of the S. fredii HH103 K-antigen polysaccharide (KPS) repeating unit. Three rkp-3 genes (rkpM, rkpP, and rkpQ) involved in the biosynthesis of the HH103 KPS repeating unit (a derivative of the pseudaminic acid) have been mutated and analyzed. All the rkp-3 mutants failed to produce KPS and their lipopolysacchari

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Gregor, A. K., B. Klubek, and E. C. Varsa. "Identification and use of actinomycetes for enhanced nodulation of soybean co-inoculated with Bradyrhizobium japonicum." Canadian Journal of Microbiology 49, no. 8 (2003): 483–91. http://dx.doi.org/10.1139/w03-061.

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The utilization of actinomycetes as potential soybean (Glycine max (L.)) co-inoculants was evaluated. Soil samples from Carbondale and Belleville, Ill., were used to inoculate pre-germinated soybean plants to determine antibiotic sensitivity in the native Bradyrhizobium japonicum population. Sensitivity was in the order kanamycin > tetracycline > oxytetracycline > rifampicin > neomycin. Antagonism by five actinomycete cultures toward seven test strains of B. japonicum was also assessed. The ranking average inhibition (across all seven B. japonicum strains) by these actino mycetes w

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Nandu, Nidhi, Michael Miller, Yanhong Tong, and Zhi-xiang Lu. "A novel dual probe-based method for mutation detection using isothermal amplification." PLOS ONE 19, no. 10 (2024): e0309541. http://dx.doi.org/10.1371/journal.pone.0309541.

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Cost efficient and rapid detection tools to detect mutations especially those linked to drug-resistance are important to address concerns of the rising multi-drug resistance infections. Here we integrated dual probes, namely a calibrator probe and an indicator probe, into isothermal amplification detection system. These two probes are designed to bind distinct regions on the same amplicon to determine the presence or absence of mutation. The calibrator probe signal is used as an internal signal calibrator for indicator probe which detects the presence or absence of the mutation. As an illustra

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Petrovskaya, Tatyana A., and Dmitry V. Tapalskiy. "Influence of different antibiotic groups on the development of mutational resistance to colistin among Klebsiella pneumoniae." Clinical Microbiology and Antimicrobial Chemotherapy 23, no. 2 (2021): 166–72. http://dx.doi.org/10.36488/cmac.2021.2.166-172.

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Objective. To determine the concentration of colistin, preventing the selection of colistin-resistant mutants of K. pneumoniae, and to evaluate the effect of antibiotics of different groups on the development of mutational resistance to colistin. Materials and Methods. Minimum inhibitory concentrations (MIC) of colistin were determined for 88 K. pneumoniae strains by the method of serial microdilutions in broth, and carbapenemase genes were detected. The selection of colistin-resistant subpopulations was performed on cation-adjusted MüllerHinton agar (MHA) with the addition of 16 mg/l colistin

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Didier, Jean-Philippe, Régis Villet, Elzbieta Huggler, et al. "Impact of Ciprofloxacin Exposure on Staphylococcus aureus Genomic Alterations Linked with Emergence of Rifampin Resistance." Antimicrobial Agents and Chemotherapy 55, no. 5 (2011): 1946–52. http://dx.doi.org/10.1128/aac.01407-10.

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ABSTRACTIntensive use of antimicrobial agents in health care settings not only leads to the selection of multiresistant nosocomial isolates ofStaphylococcus aureusbut may also promote endogenous, resistance-conferring mutations in bacterial genes that encode drug targets. We evaluated the spectrum of rifampin resistance-conferring mutations in cultures of methicillin-susceptibleS. aureus(MSSA) or methicillin-resistantS. aureus(MRSA) strains exposedin vitroto sub-MICs of ciprofloxacin. Growth of ciprofloxacin-susceptible MRSA strain MRGR3 and ciprofloxacin-resistant MSSA strain RA1 (a NCTC 8325

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Purwantari, N. D., and E. Sutedi. "Response of Calliandra calothyrsus to inoculation of mutant strain of rhizobia." Jurnal Ilmu Ternak dan Veteriner 10, no. 3 (2012): 182–89. https://doi.org/10.14334/jitv.v10i3.442.

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Rifampicin mutants of rhizobial strain CB3171rif50 and CB3090rif100 were the most effective nitrogen fixing strain of rhizobia selected under axenic condition. An experiment was conducted to evaluate the symbiotic response of C. Calothyrsus inoculated by CB3171rif50 or CB3090rif100 grown in the field, on latosol soil with pH 5,2. Plants were either (1) inoculated with mutant strain CB3171rif50, (2) inoculated with mutant strain mutant CB3090rif100 (3) uninoculated and without nitrogen addition or (4) uninoculated and with nitrogen fertilizer as a basal fertilizer. Treatments were replicated fo

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