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Journal articles on the topic 'Rigidité du substrat'

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1

Banerjee, S., and M. C. Marchetti. "Substrate rigidity deforms and polarizes active gels." EPL (Europhysics Letters) 96, no. 2 (2011): 28003. http://dx.doi.org/10.1209/0295-5075/96/28003.

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2

York, B. R., S. A. Solin, N. Wada, Rasik H. Raythatha, Ivy D. Johnson, and Thomas J. Pinnavaia. "Substrate rigidity effects in mixed layered solids." Solid State Communications 54, no. 6 (1985): 475–78. http://dx.doi.org/10.1016/0038-1098(85)90650-7.

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3

Lovett, David B., Nandini Shekhar, Jeffrey A. Nickerson, Kyle J. Roux, and Tanmay P. Lele. "Modulation of Nuclear Shape by Substrate Rigidity." Cellular and Molecular Bioengineering 6, no. 2 (2013): 230–38. http://dx.doi.org/10.1007/s12195-013-0270-2.

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4

Roberts, M. W., C. B. Clemons, J. P. Wilber, G. W. Young, A. Buldum, and D. D. Quinn. "Continuum Plate Theory and Atomistic Modeling to Find the Flexural Rigidity of a Graphene Sheet Interacting with a Substrate." Journal of Nanotechnology 2010 (2010): 1–8. http://dx.doi.org/10.1155/2010/868492.

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Using a combination of continuum modeling, atomistic simulations, and numerical optimization, we estimate the flexural rigidity of a graphene sheet. We consider a rectangular sheet that is initially parallel to a rigid substrate. The sheet interacts with the substrate by van der Waals forces and deflects in response to loading on a pair of opposite edges. To estimate the flexural rigidity, we model the graphene sheet as a continuum and numerically solve an appropriate differential equation for the transverse deflection. This solution depends on the flexural rigidity. We then use an optimizatio
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5

Doss, Bryant L., Meng Pan, Mukund Gupta, et al. "Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress." Proceedings of the National Academy of Sciences 117, no. 23 (2020): 12817–25. http://dx.doi.org/10.1073/pnas.1917555117.

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Morphogenesis, tumor formation, and wound healing are regulated by tissue rigidity. Focal adhesion behavior is locally regulated by stiffness; however, how cells globally adapt, detect, and respond to rigidity remains unknown. Here, we studied the interplay between the rheological properties of the cytoskeleton and matrix rigidity. We seeded fibroblasts onto flexible microfabricated pillar arrays with varying stiffness and simultaneously measured the cytoskeleton organization, traction forces, and cell-rigidity responses at both the adhesion and cell scale. Cells adopted a rigidity-dependent p
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6

Ni, Yong, and Martin Y. M. Chiang. "Cell morphology and migration linked to substrate rigidity." Soft Matter 3, no. 10 (2007): 1285. http://dx.doi.org/10.1039/b703376a.

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7

Wang, ZQ, ZL Dan, and J. Wu. "A Simple Solution to the Cylindrical Indentation of an Elastic Compressible Thin Layer Resting on a Rigid Substrate." Journal of Physics: Conference Series 2095, no. 1 (2021): 012094. http://dx.doi.org/10.1088/1742-6596/2095/1/012094.

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Abstract In this paper, an analytical model is presented to study the contact that recedes between an elastic thin film that could be compressed and a substrate of rigidity. The surface of rigidity was formed due to cylindrical indentation. The substrate was assumed to be a rough surface without any friction. Further, the contact width of the substrate was derived, and the relationship between the compression force, compression depth, and the compression width was determined using the energy method. Finally, the obtained results were validated using finite element analysis.
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8

Wang, Hong-Bei, Micah Dembo, and Yu-Li Wang. "Substrate flexibility regulates growth and apoptosis of normal but not transformed cells." American Journal of Physiology-Cell Physiology 279, no. 5 (2000): C1345—C1350. http://dx.doi.org/10.1152/ajpcell.2000.279.5.c1345.

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One of the hallmarks of oncogenic transformation is anchorage-independent growth (27). Here we demonstrate that responses to substrate rigidity play a major role in distinguishing the growth behavior of normal cells from that of transformed cells. We cultured normal or H- ras-transformed NIH 3T3 cells on flexible collagen-coated polyacrylamide substrates with similar chemical properties but different rigidity. Compared with cells cultured on stiff substrates, nontransformed cells on flexible substrates showed a decrease in the rate of DNA synthesis and an increase in the rate of apoptosis. The
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9

Boccafoschi, Francesca, Marco Rasponi, Cecilia Mosca, Erica Bocchi, and Simone Vesentini. "Study of Cellular Adhesion by Means of Micropillar Surface Topologies." Advanced Materials Research 409 (November 2011): 105–10. http://dx.doi.org/10.4028/www.scientific.net/amr.409.105.

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It is well-known that cellular behavior can be guided by chemical signals and physical interactions at the cell-substrate interface. The patterns that cells encounter in their natural environment include nanometer-to-micrometer-sized topographies comprising extracellular matrix, proteins, and adjacent cells. Whether cells transduce substrate rigidity at the microscopic scale (for example, sensing the rigidity between adhesion sites) or the nanoscopic scale remains an open question. Here we report that micromolded elastomeric micropost arrays can decouple substrate rigidity from adhesive and su
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10

Guo, Wei-hui, Margo T. Frey, Nancy A. Burnham, and Yu-li Wang. "Substrate Rigidity Regulates the Formation and Maintenance of Tissues." Biophysical Journal 90, no. 6 (2006): 2213–20. http://dx.doi.org/10.1529/biophysj.105.070144.

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11

O’Connor, Roddy S., Xueli Hao, Keyue Shen, et al. "Substrate Rigidity Regulates Human T Cell Activation and Proliferation." Journal of Immunology 189, no. 3 (2012): 1330–39. http://dx.doi.org/10.4049/jimmunol.1102757.

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12

Voloshin, Arkady. "Modeling Cell Movement on a Substrate with Variable Rigidity." International journal of Biomedical Engineering and Science 3, no. 1 (2016): 19–36. http://dx.doi.org/10.5121/ijbes.2016.3102.

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13

Simsek, Ahmet Nihat, Andrea Braeutigam, Matthias D. Koch, et al. "Substrate-rigidity dependent migration of an idealized twitching bacterium." Soft Matter 15, no. 30 (2019): 6224–36. http://dx.doi.org/10.1039/c9sm00541b.

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14

Douezan, Stéphane, Julien Dumond, and Françoise Brochard-Wyart. "Wetting transitions of cellular aggregates induced by substrate rigidity." Soft Matter 8, no. 17 (2012): 4578. http://dx.doi.org/10.1039/c2sm07418d.

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15

Tee, Shang-You, Jianping Fu, Christopher S. Chen, and Paul A. Janmey. "Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness." Biophysical Journal 100, no. 3 (2011): 303a. http://dx.doi.org/10.1016/j.bpj.2010.12.1856.

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16

Tee, Shang-You, Jianping Fu, Christopher S. Chen, and Paul A. Janmey. "Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness." Biophysical Journal 100, no. 5 (2011): L25—L27. http://dx.doi.org/10.1016/j.bpj.2010.12.3744.

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17

Poddar, Souvik, Aerial M. Pratt, Paul B. Orndorff, Arjan van der Vaart, Wade D. Van Horn, and Marcia Levitus. "Uracil-DNA glycosylase efficiency is modulated by substrate rigidity." Biophysical Journal 122, no. 3 (2023): 149a. http://dx.doi.org/10.1016/j.bpj.2022.11.1004.

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18

Alegre-Cebollada, Jorge, Carla Huerta-Lopez, Alejandro Clemente-Manteca, et al. "Cell response to substrate energy dissipation outweighs rigidity sensing." Biophysical Journal 122, no. 3 (2023): 292a. http://dx.doi.org/10.1016/j.bpj.2022.11.1652.

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19

Schmidt, Thomas, Hayri E. Balcioglu, Rolf Harkes, and Erik H. J. Danen. "Substrate Rigidity Modulates the Composition in Cell-Matrix Adhesions." Biophysical Journal 114, no. 3 (2018): 19a. http://dx.doi.org/10.1016/j.bpj.2017.11.149.

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20

Venugopal, Balu, Pankaj Mogha, Jyotsna Dhawan, and Abhijit Majumder. "Cell density overrides the effect of substrate stiffness on human mesenchymal stem cells’ morphology and proliferation." Biomaterials Science 6, no. 5 (2018): 1109–19. http://dx.doi.org/10.1039/c7bm00853h.

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21

Leach, Jennie B., Xin Q. Brown, Jeffrey G. Jacot, Paul A. DiMilla, and Joyce Y. Wong. "Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity." Journal of Neural Engineering 4, no. 2 (2007): 26–34. http://dx.doi.org/10.1088/1741-2560/4/2/003.

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22

Krivitskaya, Alexandra V., та Maria G. Khrenova. "Influence of the Active Site Flexibility on the Efficiency of Substrate Activation in the Active Sites of Bi-Zinc Metallo-β-Lactamases". Molecules 27, № 20 (2022): 7031. http://dx.doi.org/10.3390/molecules27207031.

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The influence of the active site flexibility on the efficiency of catalytic reaction is studied by taking two members of metallo-β-lactamases, L1 and NDM-1, with the same substrate, imipenem. Active sites of these proteins are covered by L10 loops, and differences in their amino acid compositions affect their rigidity. A more flexible loop in the NDM-1 brings additional flexibility to the active site in the ES complex. This is pronounced in wider distributions of key interatomic distances, such as the distance of the nucleophilic attack, coordination bond lengths, and covalent bond lengths in
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23

Lo, Chun-Min, Hong-Bei Wang, Micah Dembo, and Yu-li Wang. "Cell Movement Is Guided by the Rigidity of the Substrate." Biophysical Journal 79, no. 1 (2000): 144–52. http://dx.doi.org/10.1016/s0006-3495(00)76279-5.

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24

Ghassemi, S., G. Meacci, S. Liu, et al. "Cells test substrate rigidity by local contractions on submicrometer pillars." Proceedings of the National Academy of Sciences 109, no. 14 (2012): 5328–33. http://dx.doi.org/10.1073/pnas.1119886109.

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25

O'Connor, Roddy, Xueli Hao, Keyue Shen, Keenan Bashour, Lance Kam, and Michael Milone. "Substrate rigidity regulates human T cell activation and proliferation (52.9)." Journal of Immunology 188, no. 1_Supplement (2012): 52.9. http://dx.doi.org/10.4049/jimmunol.188.supp.52.9.

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Abstract Adoptive immunotherapy using cultured T cells holds promise for the treatment of cancer and infectious disease. Culture platforms based upon hard materials, such as polystyrene plastic, form the basis of many culture systems. The mechanical properties of a culture substrate can influence cellular adhesion, proliferation, and differentiation. We explored the impact of substrate stiffness on ex vivo T cell activation and polyclonal expansion using substrates with variable rigidity manufactured from poly(dimethylsiloxane) (PDMS), a biocompatible silicone elastomer. We show that the IL-2
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26

Kostic, Ana, and Michael P. Sheetz. "Fibronectin Rigidity Response through Fyn and p130Cas Recruitment to the Leading Edge." Molecular Biology of the Cell 17, no. 6 (2006): 2684–95. http://dx.doi.org/10.1091/mbc.e05-12-1161.

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Cell motility on extracellular matrices critically depends on matrix rigidity, which affects cell adhesion and formation of focal contacts. Receptor-like protein tyrosine phosphatase alpha (RPTPα) and the αvβ3 integrin form a rigidity-responsive complex at the leading edge. Here we show that the rigidity response through increased spreading and growth correlates with leading edge recruitment of Fyn, but not endogenous c-Src. Recruitment of Fyn requires the palmitoylation site near the N-terminus and addition of that site to c-Src enables it to support a rigidity response. In all cases, the rig
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27

Hirata, Hiroaki, Keng-Hwee Chiam, Chwee Teck Lim, and Masahiro Sokabe. "Actin flow and talin dynamics govern rigidity sensing in actin–integrin linkage through talin extension." Journal of The Royal Society Interface 11, no. 99 (2014): 20140734. http://dx.doi.org/10.1098/rsif.2014.0734.

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At cell–substrate adhesion sites, the linkage between actin filaments and integrin is regulated by mechanical stiffness of the substrate. Of potential molecular regulators, the linker proteins talin and vinculin are of particular interest because mechanical extension of talin induces vinculin binding with talin, which reinforces the actin–integrin linkage. For understanding the molecular and biophysical mechanism of rigidity sensing at cell–substrate adhesion sites, we constructed a simple physical model to examine a role of talin extension in the stiffness-dependent regulation of actin–integr
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28

Storey, E., and M. F. Beal. "Neurochemical substrates of rigidity and chorea in Huntington's disease." Brain 116, no. 5 (1993): 1201–22. http://dx.doi.org/10.1093/brain/116.5.1201.

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29

Balcioglu, Hayri E., Rolf Harkes, Erik H. J. Danen, and Thomas Schmidt. "Substrate rigidity modulates traction forces and stoichiometry of cell–matrix adhesions." Journal of Chemical Physics 156, no. 8 (2022): 085101. http://dx.doi.org/10.1063/5.0077004.

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In cell–matrix adhesions, integrin receptors and associated proteins provide a dynamic coupling of the extracellular matrix (ECM) to the cytoskeleton. This allows bidirectional transmission of forces between the ECM and the cytoskeleton, which tunes intracellular signaling cascades that control survival, proliferation, differentiation, and motility. The quantitative relationships between recruitment of distinct cell–matrix adhesion proteins and local cellular traction forces are not known. Here, we applied quantitative super-resolution microscopy to cell–matrix adhesions formed on fibronectin-
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30

Sun, Yubing, Liang-Ting Jiang, Ryoji Okada, and Jianping Fu. "UV-Modulated Substrate Rigidity for Multiscale Study of Mechanoresponsive Cellular Behaviors." Langmuir 28, no. 29 (2012): 10789–96. http://dx.doi.org/10.1021/la300978x.

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31

Frey, Margo T., and Yu-li Wang. "A photo-modulatable material for probing cellular responses to substrate rigidity." Soft Matter 5, no. 9 (2009): 1918. http://dx.doi.org/10.1039/b818104g.

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32

Watanabe, Takamitsu, Rebecca P. Lawson, Ylva S. E. Walldén, and Geraint Rees. "A Neuroanatomical Substrate Linking Perceptual Stability to Cognitive Rigidity in Autism." Journal of Neuroscience 39, no. 33 (2019): 6540–54. http://dx.doi.org/10.1523/jneurosci.2831-18.2019.

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33

Wong, Stephanie, Wei-Hui Guo, and Yu-Li Wang. "Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area." Proceedings of the National Academy of Sciences 111, no. 48 (2014): 17176–81. http://dx.doi.org/10.1073/pnas.1412285111.

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34

Higgs, Henry N. "The harder the better: effects of substrate rigidity on cell motility." Trends in Biochemical Sciences 25, no. 9 (2000): 427. http://dx.doi.org/10.1016/s0968-0004(00)01653-4.

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35

Nemir, Stephanie, and Jennifer L. West. "Synthetic Materials in the Study of Cell Response to Substrate Rigidity." Annals of Biomedical Engineering 38, no. 1 (2009): 2–20. http://dx.doi.org/10.1007/s10439-009-9811-1.

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36

Breuls, Roel, Astrid Bakker, Ruud Bank, Vincent Everts, and Theo Smit. "SUBSTRATE RIGIDITY AND EXTRACELLULAR MATRIX COMPOSITION INTERACT TO DETERMINE CELL BEHAVIOR." Journal of Biomechanics 41 (July 2008): S461. http://dx.doi.org/10.1016/s0021-9290(08)70460-3.

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37

Barreto, Sara, Cécile M. Perrault, and Damien Lacroix. "EFFECT OF THE CYTOSKELETON FIBERS AND SUBSTRATE RIGIDITY ON ADHERENT CELLS." Journal of Biomechanics 45 (July 2012): S418. http://dx.doi.org/10.1016/s0021-9290(12)70419-0.

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38

Sarkar, Anwesha, and Xuefeng Wang. "Integrin Molecular Tensions in Live Cells are Altered by Substrate Rigidity." Biophysical Journal 114, no. 3 (2018): 324a. http://dx.doi.org/10.1016/j.bpj.2017.11.1818.

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39

Kim, Tae-Jin, Jihye Seong, Mingxing Ouyang, et al. "Substrate rigidity regulates Ca2+oscillation via RhoA pathway in stem cells." Journal of Cellular Physiology 218, no. 2 (2009): 285–93. http://dx.doi.org/10.1002/jcp.21598.

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40

Mantena, P. Raju, Tezeswi Tadepalli, Brahmananda Pramanik, et al. "Energy Dissipation and the High-Strain Rate Dynamic Response of Vertically Aligned Carbon Nanotube Ensembles Grown on Silicon Wafer Substrate." Journal of Nanomaterials 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/259458.

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The dynamic mechanical behavior and high-strain rate response characteristics of a functionally graded material (FGM) system consisting of vertically aligned carbon nanotube ensembles grown on silicon wafer substrate (VACNT-Si) are presented. Flexural rigidity (storage modulus) and loss factor (damping) were measured with a dynamic mechanical analyzer in an oscillatory three-point bending mode. It was found that the functionally graded VACNT-Si exhibited significantly higher damping without sacrificing flexural rigidity. A Split-Hopkinson pressure bar (SHPB) was used for determining the system
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41

Shi, Lingting, Jounghyun Helen Lee, and Lance Kam. "Substrate rigidity affects human regulatory T cell induction in vitro." Journal of Immunology 202, no. 1_Supplement (2019): 128.18. http://dx.doi.org/10.4049/jimmunol.202.supp.128.18.

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Abstract Immunotherapy using regulatory T cells (Tregs) has shown recent successes in the treatment of autoimmune and inflammatory diseases such as type 1 diabetes. While natural Tregs are unstable and dysfunctional in the inflammatory milieu, induced Tregs are more potent and durable. Tregs can be induced from CD4+CD25− T cells in vitro with TGF-β and IL-2 during activation. Chemical pathways in Treg induction have been heavily investigated, but the impact of mechanical cues on Treg induction has not been thoroughly explored. As T cell activation has been shown to be sensitive to the rigidity
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42

Zheng, Yonggang, Huayuan Tang, Hongfei Ye, and Hongwu Zhang. "Adhesion and bending rigidity-mediated wrapping of carbon nanotubes by a substrate-supported cell membrane." RSC Advances 5, no. 54 (2015): 43772–79. http://dx.doi.org/10.1039/c5ra04426j.

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The adhesion and bending rigidity-mediated wrapping of carbon nanotubes by a substrate-supported cell membrane has been explored and phase diagrams that characterize the effect of the energy competition on the equilibrium configuration have been presented.
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43

Chaky, J., K. Anderson, M. Moss, and L. Vaillancourt. "Surface Hydrophobicity and Surface Rigidity Induce Spore Germination in Colletotrichum graminicola." Phytopathology® 91, no. 6 (2001): 558–64. http://dx.doi.org/10.1094/phyto.2001.91.6.558.

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We investigated the relationship between physical characteristics of artificial surfaces, spore attachment, and spore germination in Colletotrichum graminicola. Surface hydrophobicity and surface rigidity were both signals for breaking dormancy and initiating spore germination, but spore attachment alone was not an important inducing signal. The presence of a carbon source overrode the necessity for a rigid, hydrophobic substrate for spore germination. Spore attachment was typically stronger to more hydrophobic surfaces, but certain hydrophilic surfaces also proved to be good substrates for sp
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44

Suhir, E. "How Compliant Should a Die-Attachment be to Protect the Chip From Substrate Bowing?" Journal of Electronic Packaging 117, no. 1 (1995): 88–92. http://dx.doi.org/10.1115/1.2792073.

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The purpose of the analysis is to find out whether die attachment can be made compliant enough to protect the chip from excessive bowing of the substrate. We showed that in a typical situation, when the substrate (card) has a significantly larger flexural rigidity than the chip, the mechanical behavior of the chip-substrate assembly is governed by a parameter u=lK/4D14, where l is half the chip’s length, D1 is its flexural rigidity, and K is the through thickness spring constant of the attachment. We found that in order for a die attachment to have an appreciable effect on chip bowing, this pa
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45

Gong, Ze, Spencer E. Szczesny, Steven R. Caliari, et al. "Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates." Proceedings of the National Academy of Sciences 115, no. 12 (2018): E2686—E2695. http://dx.doi.org/10.1073/pnas.1716620115.

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Recent evidence has shown that, in addition to rigidity, the viscous response of the extracellular matrix (ECM) significantly affects the behavior and function of cells. However, the mechanism behind such mechanosensitivity toward viscoelasticity remains unclear. In this study, we systematically examined the dynamics of motor clutches (i.e., focal adhesions) formed between the cell and a viscoelastic substrate using analytical methods and direct Monte Carlo simulation. Interestingly, we observe that, for low ECM rigidity, maximum cell spreading is achieved at an optimal level of viscosity in w
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46

Huo, Wu Jun, Xu Liu, Bin Hu, and Zhi Peng Wang. "Research on Microstructure and Wear-Resisting Property of NiCrWMo Laser Cladding on K418." Applied Mechanics and Materials 633-634 (September 2014): 782–86. http://dx.doi.org/10.4028/www.scientific.net/amm.633-634.782.

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Laser cladding on K418 substrate using NiCrWMo powder by Nb:YAG laser was carried out for the repair of aero blades. The microstructure and microhardness of cladding layers were investigated. The result showed that using the correct nickel based alloy powder, at the craft parameter of electric current 160 A, pulse width 8mses, the frequency 4 Hz, the surface is balanced and continuous; the microstructure is close and uniformity; the cladding is well combined with the substrate without flaw; the rigidity of the cladding is higher than the substrate .
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47

Yakupov, Samat N., and Ruslan I. Gubaidullin. "Rigidity, adhesion and delamination of the coating in the “substrate - coating” system." Structural Mechanics of Engineering Constructions and Buildings 18, no. 3 (2022): 204–14. http://dx.doi.org/10.22363/1815-5235-2022-18-3-204-214.

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Protective coatings are widely used in all branches of production and life. The necessary qualities of coatings are provided by developing complex thin-layer compositions. The complexity of the structure of the coating also arises during operation as a result of the influence of the environment, physical fields, human factor. Many coatings are initially formed directly on the surfaces of structures with initially complex geometry. At the same time, a number of smart coatings, along with a complex structure, change their physical and mechanical properties when triggered. When choosing a coating
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48

Giannone, Grégory, and Michael P. Sheetz. "Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways." Trends in Cell Biology 16, no. 4 (2006): 213–23. http://dx.doi.org/10.1016/j.tcb.2006.02.005.

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49

Yip, Ai Kia, Katsuhiko Iwasaki, Chaitanya Ursekar, et al. "Cellular Response to Substrate Rigidity Is Governed by Either Stress or Strain." Biophysical Journal 104, no. 1 (2013): 19–29. http://dx.doi.org/10.1016/j.bpj.2012.11.3805.

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50

Indra, Indrajyoti, and Karen A. Beningo. "An in vitro correlation of metastatic capacity, substrate rigidity, and ECM composition." Journal of Cellular Biochemistry 112, no. 11 (2011): 3151–58. http://dx.doi.org/10.1002/jcb.23241.

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