Relevant bibliographies by topics / Ripostatine

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Ripostatine'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Ripostatine"

1

Shenderman, Vladyslav, and Evgeny V. Prusov. "Synthesis and biological evaluation of fluorinated analogues of ripostatin A." Organic & Biomolecular Chemistry 17, no. 6 (2019): 1362–64. http://dx.doi.org/10.1039/c8ob02890g.

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Glaus, Florian, Darija Dedić, Priyanka Tare, Valakunja Nagaraja, Liliana Rodrigues, José Antonio Aínsa, Jens Kunze, et al. "Total Synthesis of Ripostatin B and Structure–Activity Relationship Studies on Ripostatin Analogs." Journal of Organic Chemistry 83, no. 13 (March 15, 2018): 7150–72. http://dx.doi.org/10.1021/acs.joc.8b00193.

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Tang, Wufeng, and Evgeny V. Prusov. "Total Synthesis of Ripostatin A." Organic Letters 14, no. 17 (August 23, 2012): 4690–93. http://dx.doi.org/10.1021/ol302219x.

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Schleicher, Kristin D., and Timothy F. Jamison. "A reductive coupling strategy towards ripostatin A." Beilstein Journal of Organic Chemistry 9 (July 31, 2013): 1533–50. http://dx.doi.org/10.3762/bjoc.9.175.

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Synthetic studies on the antibiotic natural product ripostatin A have been carried out with the aim to construct the C9−C10 bond by a nickel(0)-catalyzed coupling reaction of an enyne and an epoxide, followed by rearrangement of the resulting dienylcyclopropane intermediate to afford the skipped 1,4,7-triene. A cyclopropyl enyne fragment corresponding to C1−C9 has been synthesized in high yield and demonstrated to be a competent substrate for the nickel(0)-catalyzed coupling with a model epoxide. Several synthetic approaches toward the C10−C26 epoxide have been pursued. The C13 stereocenter can be set by allylation and reductive decyanation of a cyanohydrin acetonide. A mild, fluoride-promoted decarboxylation enables construction of the C15−C16 bond by an aldol reaction. The product of this transformation is of the correct oxidation state and potentially three steps removed from the targeted epoxide fragment.
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Tang, Wufeng, Shuang Liu, David Degen, Richard H. Ebright, and Evgeny V. Prusov. "Synthesis and Evaluation of Novel Analogues of Ripostatins." Chemistry - A European Journal 20, no. 38 (August 11, 2014): 12310–19. http://dx.doi.org/10.1002/chem.201403176.

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Glaus, Florian, and Karl-Heinz Altmann. "Total Synthesis of the Myxobacterial Macrolide Ripostatin B." CHIMIA International Journal for Chemistry 67, no. 4 (April 24, 2013): 227–30. http://dx.doi.org/10.2533/chimia.2013.227.

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O'Neill, Alexander, Brunello Oliva, Christopher Storey, Anthony Hoyle, Colin Fishwick, and Ian Chopra. "RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 44, no. 11 (November 1, 2000): 3163–66. http://dx.doi.org/10.1128/aac.44.11.3163-3166.2000.

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ABSTRACT A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase β-subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates.
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Glaus, Florian, and Karl-Heinz Altmann. "ChemInform Abstract: Total Synthesis of the Myxobacterial Macrolide Ripostatin B." ChemInform 44, no. 39 (September 5, 2013): no. http://dx.doi.org/10.1002/chin.201339240.

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Fu, Chengzhang, David Auerbach, Yanyan Li, Ullrich Scheid, Eva Luxenburger, Ronald Garcia, Herbert Irschik, and Rolf Müller. "Solving the Puzzle of One-Carbon Loss in Ripostatin Biosynthesis." Angewandte Chemie International Edition 56, no. 8 (January 18, 2017): 2192–97. http://dx.doi.org/10.1002/anie.201609950.

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Glaus, Florian, and Karl-Heinz Altmann. "Total Synthesis of the Bacterial RNA Polymerase Inhibitor Ripostatin B." Angewandte Chemie 124, no. 14 (February 29, 2012): 3461–65. http://dx.doi.org/10.1002/ange.201200871.

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Dissertations / Theses on the topic "Ripostatine"

1

Hemmery, Hélène. "Étude de la synthèse totale de la ripostatine A." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112336/document.

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Cette thèse est consacrée à l’étude de la synthèse totale de la ripostatine A, un antibiotique inhibiteur de l’ARN polymérase des bactéries, isolé en 1995 à partir de la myxobactérie Sorangium cellulosum. La ripostatine A est caractérisée par une lactone à 14 chaînons et un lactol à 6 chaînons ; elle comporte trois doubles liaisons et trois centres stéréogènes. Les deux voies de synthèse envisagées de la ripostatine A comportaient comme étapes clés une cycloaddition 1,3-dipolaire d’oxyde de nitrile et une macrolactonisation. Des accès stéréocontrôlés à deux précurseurs importants comportant un motif 1,4-diène ont été développés, notamment à l’aide d’une carboalumination d’alcyne. Des β-hydroxycétones, précurseurs avancés dans la synthèse, ont été obtenues à partir de ces 1,4 diènes. Un couplage de Stille, entre un alcénylstannane qui a été synthétisé et un halogénure dérivé d’une des β-hydroxycétones préparées, reste à réaliser afin d’assembler le squelette de la ripostatine A
This thesis is dedicated to the study of the total synthesis of ripostatin A, an antibiotic which inhibits eubacterial RNA polymerase, isolated in 1995 from the myxobacteria Sorangium cellulosum. Ripostatin A is characterized by a 14 membered lactone and a 6 membered lactol, it contains three double bonds and three stereogenic centers. The two synthetic routes envisaged for ripostatin A included as key steps a nitrile oxide 1,3 dipolar cycloaddition and a macrolactonisation. Stereocontroled accesses to two important precursors containing a 1,4-diene moiety were developed, using in particular an alkyne carboalumination. Advanced precursors, β-hydroxyketones, were obtained from these 1,4 dienes. A Stille coupling between a synthesized stannane and an halide derived from one of the β-hydroxyketones, remains to be realized in order to assemble the skeleton of ripostatin A
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Tang, Wufeng [Verfasser]. "Studien zum synthetischen Zugang zu Ripostatinen und deren Analoga / Wufeng Tang." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2014. http://d-nb.info/1063002125/34.

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Winter, Philipp [Verfasser], Mathias [Akademischer Betreuer] Christmann, and Alois [Akademischer Betreuer] Fürstner. "Totalsynthese des RNA-Polymerase inhibitors Ripostatin B / Philipp Winter. Betreuer: Mathias Christmann. Gutachter: Alois Fürstner." Dortmund : Universitätsbibliothek Dortmund, 2012. http://d-nb.info/1099296757/34.

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Schleicher, Kristin D. (Kristin Diann). "Nickel-catalyzed preparation of acrylamides from alpha olefins and isocyanates ; Synthetic studies toward ripostatin A." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62138.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.
Vita. Cataloged from PDF version of thesis.
Includes bibliographical references.
Chapter I. In the presence of the N-heterocyclic carbene ligand IPr, the nickel(0)-catalyzed coupling reaction of a-olefins and branched aliphatic isocyanates provides c,-unsaturated amides arising from preferential C-C bond formation at the 2-position of the olefin. This sense of regioselectivity contrasts with the observed carboxamidation at the 1-position of the olefin when phosphine ligands are used. In this reaction, a simple alkene acts as the functional equivalent of a 2-alkenylmetal reagent. ... Chapter II. Synthetic studies on the antibiotic natural product ripostatin A have been carried out with the aim of constructing the C9-C1O bond via a nickel(0)-catalyzed coupling reaction of enynes and epoxides developed in our laboratory, followed by rearrangement of the resulting dienylcyclopropane intermediate to afford the skipped 1,4,7-triene. ... A cyclopropyl enyne fragment corresponding to C1-C9 of ripostatin A can be synthesized in high yield over 10 steps and was demonstrated to be a competent substrate for the nickel(0)-catalyzed coupling reaction with a model epoxide. The origin of regioselectivity in this particular transformation is also discussed. ... Several synthetic approaches towards the desired C1O-C26 epoxide fragment have been pursued. The presence of the C19-C20 trisubstituted olefin renders introduction of the epoxide via oxidation of or iodocyclization onto a terminal alkene unsuitable. Access of the epoxide by way of nucleophlic displacement should circumvent these problems. The C13 stereocenter can be set via the allylation and reductive decyanation of a cyanohydrin acetonide. ... A mild, fluoride-promoted decarboxylation enables the construction of the C15-C16 bond via an aldol reaction. This product of this transformation is of the correct oxidation state and three steps removed from the targeted epoxide fragment.
by Kristin D. Schleicher.
Ph.D.
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5

Kujat, Christof [Verfasser]. "Studien zur Totalsynthese von Ripostatin A & B / von Christof Kujat." 2007. http://d-nb.info/984056041/34.

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