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Journal articles on the topic 'Risk Management in Clinical Research Digital Pharmacovigilance Solutions'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Vani, Pathuri. "Enhancing Pharmacovigilance in Clinical Trials." European Journal of Advances in Engineering and Technology 10, no. 7 (2023): 88–93. https://doi.org/10.5281/zenodo.15044250.

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Pharmacovigilance plays a critical role in ensuring drug safety throughout clinical trials, yet numerous challenges hinder its effectiveness. Issues such as data integrity, adverse event reporting inconsistencies, and safety monitoring in special populations create gaps in risk assessment. Additionally, global multi-center trials face regulatory discrepancies that complicate pharmacovigilance implementation. Advancements in digital and AI-driven solutions offer new opportunities to enhance real-time monitoring and risk management. This paper will examine the key challenges in pharmacovigilance

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Hussain, Mohd Shakir, Ajit Kumar Mishra, and Rishabh Pandey. "Pharmacovigilance: Enhancing Medication Safety Through Risk Management and Innovation." International Journal of Medical Science And Diagnosis Research 9, no. 3 (2025): 37–45. https://doi.org/10.32553/ijmsdr.v9i3.1054.

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Pharmacovigilance is a crucial component of healthcare systems, aimed at identifying, assessing, and preventing adverse drug reactions (ADRs) to ensure medication safety and effectiveness. This paper presents a comprehensive overview of pharmacovigilance principles, challenges, and future directions. The escalating volume of ADR data necessitates a robust global network of pharmacovigilance centres overseen by the Uppsala Monitoring Centre to uncover previously unnoticed ADRs. Despite notable advancements, underreporting of ADRs remains a challenge, particularly in developing nations, emphasiz

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Choudhari, Mr Narendra Kaluram. "A Review: Pharmacovigilance and Studies of Clinical Research for Health Care." International Journal for Research in Applied Science and Engineering Technology 13, no. 4 (2025): 4545–52. https://doi.org/10.22214/ijraset.2025.69294.

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Pharmacovigilance (PV) plays a critical role in ensuring drug safety by monitoring, detecting, assessing, and preventing adverse drug reactions (ADRs) and other medication-related risks. This review explores the evolution of pharmacovigilance, from its historical foundations to modern advancements in artificial intelligence, big data analytics, and real-world evidence (RWE). Key topics include global regulatory frameworks (e.g., WHO, ICH, FDA, EMA), methodologies for signal detection, risk management plans (RMPs), and the growing importance of patient-reported outcomes. Challenges such as unde

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Tinatin Gogrichiani. "Organization of the data monitoring process within the framework of clinical trials." International Journal of Science and Research Archive 14, no. 1 (2025): 1642–48. https://doi.org/10.30574/ijsra.2025.14.1.2627.

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This article explores innovative methodologies for organizing the data monitoring process in clinical trials, with a focus on traditional, remote, and risk-based approaches, as well as the integration of digital technologies. Through a comparative analysis of monitoring models, the study highlights the advantages of combining these methods in multicenter projects to enhance data accuracy, security, and compliance with modern regulatory standards. The findings demonstrate that digitalization and centralized systems significantly improve monitoring efficiency and risk management, offering action

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Bowles, Charlotte, Matthew Prettyjohns, Nathan Bromham, Alice Evans, Jenni Washington, and Rebecca Shepherd. "PD115 Digital Health Solutions: Health Technology Assessment Of Digital Platforms For Personalized Management, Education, And Support For People With Diabetes." International Journal of Technology Assessment in Health Care 40, S1 (2024): S138. https://doi.org/10.1017/s0266462324003556.

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IntroductionApproximately five million people live with diabetes in the UK. The cost of this is approximately 10 percent of the National Health Service (NHS) budget. Wales has the highest prevalence of diabetes of any country in the UK. Educating people on how to best manage their condition can minimize associated complications. Digital platforms can aid self-management and improve risk factors.MethodsThis rapid review aimed to address the following research question: What is the clinical and cost effectiveness of digital platforms for personalized diabetes management to inform decision-making

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Laiba Asif, Muhammad Danyal Khan, Maheen Rafique, et al. "Leveraging Artificial Intelligence in Pharmacy and Clinical Pharmacy Transformative Innovations for Precision, Operational Efficiency, and Enhanced Patient-Centered Care." Indus Journal of Bioscience Research 3, no. 5 (2025): 1–12. https://doi.org/10.70749/ijbr.v3i5.1225.

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By improving accuracy, operational effectiveness, and patient-centered care, the use of artificial intelligence (AI) in clinical pharmacy and pharmacy is transforming healthcare. Drug discovery, customized medicine, and pharmaceutical treatment management are being optimized by AI-driven advances, including machine learning algorithms, natural language processing, and predictive analytics. AI-powered decision support systems in clinical pharmacies increase workflow efficiency, decrease adverse medication reactions, and improve prescription accuracy. Real-time patient monitoring, AI-assisted dr

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Almalki, Manal. "Assessing the features of mobile Apps for self-management of postpartum depression." African Journal of Reproductive Health 29, no. 3 (2025): 132–42. https://doi.org/10.29063/ajrh2025/v29i3.16.

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Postpartum depression (PPD) is a significant global health concern, impacting the well-being of mothers and their infants during the postpartum period. Digital health solutions, particularly mobile applications, have emerged as promising tools for PPD management. This study systematically evaluates the landscape of PPD apps, identifying 115 relevant applications available on iOS and Android platforms. Through a comprehensive analysis, we assess their availability, popularity, key features, and technological advancements. Many of these apps integrate artificial intelligence (AI), machine learni

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Juma, Aisha, and Suleiman Nazik. "Risk Management and Patient Safety; The National Safety and Quality Health Service (NSQHS) Standards." Global Journal of Health Sciences 10, no. 1 (2025): 72–82. https://doi.org/10.47604/gjhs.3209.

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Purpose: The research aims at modifying two Standards of the National Safety and Quality Health Service (NSQHS) framework for UAE healthcare institutions which include both Clinical Governance and Medication Safety standards. This adaptation process is crucial for linking these standards to UAE regulations and healthcare infrastructure because of substantial cultural as well as legal technological and organizational differences between Australia and the UAE. Healthcare facilities in UAE will receive upgraded patient safety and quality of care through standards adaptations which reflect their s

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Daly, Robert Michael, Kevin Nicholas, Jessica Flynn, et al. "Association between remote monitoring and acute care visits in high-risk patients initiating intravenous antineoplastic therapy." Journal of Clinical Oncology 40, no. 16_suppl (2022): 1578. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.1578.

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1578 Background: Acute care visits (emergency department [ED] visits or inpatient admissions) for patients with cancer are growing disproportionately. Traditional oncology care models have not effectively identified and managed at-risk patients to prevent acute care. A next step is to harness advances in technology and mobile applications to enable patients to report symptoms any time, enabling “digital hovering” - intensive monitoring and management of high-risk patients. Our objective was to evaluate a digital platform that identifies and remotely monitors high-risk patients initiating intra

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Vandenberk, Thijs, Valerie Storms, Dorien Lanssens, et al. "A Vendor-Independent Mobile Health Monitoring Platform for Digital Health Studies: Development and Usability Study." JMIR mHealth and uHealth 7, no. 10 (2019): e12586. http://dx.doi.org/10.2196/12586.

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Background Medical smartphone apps and mobile health devices are rapidly entering mainstream use because of the rising number of smartphone users. Consequently, a large amount of consumer-generated data is being collected. Technological advances in innovative sensory systems have enabled data connectivity and aggregation to become cornerstones in developing workable solutions for remote monitoring systems in clinical practice. However, few systems are currently available to handle such data, especially for clinical use. Objective The aim of this study was to develop and implement the digital h

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He, Qiang, Patrick J. Silva, Marcia Ory, Ni Wang, and Kenneth S. Ramos. "Application of Digital Informatics in Precision Prevention, Epidemiology, and Clinicogenomics Research to Advance Precision Healthcare." Yearbook of Medical Informatics 33, no. 01 (2024): 250–61. https://doi.org/10.1055/s-0044-1800753.

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Summary Objectives: To summarize recent public health informatics and precision epidemiology developments impacting the healthcare ecosystem. The influence of new technologies and precision approaches in surveillance and management of chronic diseases is high-lighted as areas of clinical practice where digital informatics can markedly improve pop-ulation health. Methods: In this narrative review, we summarized the main themes from research and practice to define disease prevention and public health trends. Publications on public health informatics and precision epidemiology were searched using

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Campbell, Matthew T., Tian Zhang, Lynda Chin, Allison Betof Warner, and Matthen Mathew. "ApricityRx companion digital therapeutic for evidence-based mitigation and phenotype-linked molecular characterization of irAEs in patients receiving immune checkpoint therapy (ICT)." Journal of Clinical Oncology 38, no. 15_suppl (2020): TPS2089. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.tps2089.

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TPS2089 Background: Presentation of immune-related adverse events (irAEs) is heterogeneous and unpredictable in patients receiving immune checkpoint therapy (ICT). ICT has been approved for cancer patients as single agent, combination of dual ICT, ICT plus chemotherapy, and ICT plus targeted therapy. Given the ever increasing complexity in recognizing and managing irAEs, coupled with the lack of skilled resources and clinical experience in real world practice, there is increasing demand for digital solutions that can detect early toxicity and support evidence-based interventions in real world

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Yasmin Usui Mifune, Isadora Teles Martins, Suzana Azevedo Golgher, Julia Biagi Utuari da Silva, Gabriel Victor Rebouças Freire, and Úrsula do Nascimento Ávilla. "Advances in the Management of Chronic Obstructive Pulmonary Disease." Asclepius International Journal of Scientific Health Science 4, no. 4 (2025): 282–92. https://doi.org/10.70779/aijshs.v4i4.90.

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IntroductionChronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms and airflow limitation. Despite extensive research, its progressive nature and systemic complications continue to challenge clinicians globally. This review explores recent developments in COPD management, including pharmacological advances, non-pharmacological strategies, and emerging technologies. Objective: The objective of this narrative review is to critically evaluate recent advances in the management of COPD, highlighting

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Sravish Nalam. "Hybrid Therapeutic Modalities: Scalable Data Infrastructure for Converging Digital and Pharmacological Treatments." Journal of Computer Science and Technology Studies 7, no. 6 (2025): 930–41. https://doi.org/10.32996/jcsts.2025.7.110.

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The remainder of this article is organized to provide a comprehensive exploration of the proposed architecture and its applications in healthcare and life sciences. Section 2 provides background on digital therapeutics evolution and reviews related work in healthcare data integration architectures, establishing the context for the proposed framework. Section 3 presents the architecture framework in detail, including core components, data integration mechanisms, and scalability design principles. Section 4 examines the AI/ML analytics layer, discussing advanced analytics capabilities and observ

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Zagarrì, Elisa, Stefania Frasson, Antonella Valerio, and Gualberto Gussoni. "Decentralized Clinical Trials in Italy: state of the art and future perspectives." AboutOpen 10 (February 10, 2023): 22–26. http://dx.doi.org/10.33393/ao.2023.2546.

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Clinical trials are an essential source of high-quality evidence for the assessment of efficacy and safety of healthcare interventions. Nowadays the main criticality of the traditional clinical trial model is perhaps the need to improve patient selection and management, in terms of initial identification, recruitment and retention. Digital technology offers operational solutions that can facilitate many of the activities involved in clinical investigation. Decentralized Clinical Trials (DCTs) could be a new option that provides for the use of remote instruments/methods/activities in the differ

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Patel, Sajan B., Fahad M. Iqbal, Kyle Lam, Amish Acharya, Hutan Ashrafian, and Ara Darzi. "Characterizing Behaviors That Influence the Implementation of Digital-Based Interventions in Health Care: Systematic Review." Journal of Medical Internet Research 27 (June 12, 2025): e56711. https://doi.org/10.2196/56711.

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Background Successful implementation of any digital intervention in a health care setting requires adoption by all stakeholders. Appropriate consideration of behavioral change is a key driver that is often overlooked during implementation. The nonadoption, abandonment, scale-up, spread, and systems (NASSS) behavioral framework offers a broad evaluation of success for digital health solutions, and the theoretical domains framework (TDF) focuses particularly on adopters, identifying determinants of behavior and potential reasons for implementation issues. Objective The aim of this study was to d

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Balbale, Salva, Maria Younan, and Mehul Raval. "INVOLVING END-USERS IN THE DESIGN OF A DIGITAL OPIOID SAFETY INTERVENTION FOR ADOLESCENTS AND YOUNG ADULTS (AYA) WITH INFLAMMATORY BOWEL DISEASES (IBD): A QUALITATIVE ANALYSIS OF PATIENTS AND CLINICIANS." Inflammatory Bowel Diseases 31, Supplement_1 (2025): S35. https://doi.org/10.1093/ibd/izae282.078.

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Abstract BACKGROUND Opioid overdoses, a leading cause of death among adolescents and young adults (AYA), often result from chronic opioid use. Opioid overdose risk is especially high among AYA with chronic digestive disorders, such as inflammatory bowel diseases (IBD), given their prevalence (about 1 in 5) of using opioids chronically. To identify AYA patient and clinician needs and expectations that should be considered in the design of a digital opioid safety intervention, Chronic Opioid Use Assessment & Screening Tool (COAST), through the lens of human-centered design. METHODS Human-cen

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Geyer, Charles, Aditya Bardia, Nadia Harbeck, et al. "lidERA Breast Cancer (BC): Phase III adjuvant study of giredestrant vs. physician’s choice of endocrine therapy (PCET) in patients (pts) with estrogen receptor-positive, HER2-negative early BC (ER+, HER2– eBC)." Journal of Clinical Oncology 41, no. 16_suppl (2023): TPS616. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.tps616.

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TPS616 Background: Despite best management with standard ETs, ≤ 20% of pts with ER+, HER2– eBC develop resistance (due to ESR1 mutations that can drive estrogen-independent transcription and proliferation) and have high recurrence rates. New treatments are needed to reduce recurrence risk and improve survival, tolerability, quality of life, and adherence. Giredestrant, a highly potent, nonsteroidal oral selective ER antagonist and degrader, achieves robust ER occupancy and is active against ER-sensitive or ESR1-mutated tumors. It is more potent in vitro and achieves higher ER occupancy in vivo

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Petsani, Despoina, Sara Ahmed, Vasileia Petronikolou, et al. "Digital Biomarkers for Supporting Transitional Care Decisions: Protocol for a Transnational Feasibility Study." JMIR Research Protocols 11, no. 1 (2022): e34573. http://dx.doi.org/10.2196/34573.

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Background Virtual Health and Wellbeing Living Lab Infrastructure is a Horizon 2020 project that aims to harmonize Living Lab procedures and facilitate access to European health and well-being research infrastructures. In this context, this study presents a joint research activity that will be conducted within Virtual Health and Wellbeing Living Lab Infrastructure in the transitional care domain to test and validate the harmonized Living Lab procedures and infrastructures. The collection of data from various sources (information and communications technology and clinical and patient-reported o

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Thakar, Anup, Kalpesh Panara, Mandip Goyal, Ritu Kumari, and Kim Sungchol. "Impact of AYUSH interventions on COVID-19: a protocol for a living systematic review and meta-analysis." F1000Research 10 (July 28, 2021): 674. http://dx.doi.org/10.12688/f1000research.55109.1.

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Background: The coronavirus disease 2019 (COVID-19) pandemic has created a great burden on governments and the medical fraternity globally. Many clinical studies from the Indian system of Traditional Medicines [Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homoeopathy (AYUSH)] have been carried out to find appropriate solutions. Through a living systematic review and meta-analysis, this study aims to determine the effectiveness of the Traditional System of Indian Medicine (AYUSH system) in lowering the incidence, duration, and severity of COVID-19. Methods: We will search the following da

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Thakar, Anup, Kalpesh Panara, Mandip Goyal, Ritu Kumari, and Kim Sungchol. "Impact of AYUSH interventions on COVID-19: a protocol for a living systematic review and meta-analysis." F1000Research 10 (March 8, 2022): 674. http://dx.doi.org/10.12688/f1000research.55109.2.

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Background: The coronavirus disease 2019 (COVID-19) pandemic has created a great burden on governments and the medical fraternity globally. Many clinical studies from the Indian system of Traditional Medicines [Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homoeopathy (AYUSH)] have been carried out to find appropriate solutions. Through a living systematic review and meta-analysis, this study aims to determine the effectiveness of the Traditional System of Indian Medicine (AYUSH system) in lowering the incidence, duration, and severity of COVID-19. Methods: We will search the following da

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GHMJ (Global Health Management Journal). "Reviewer Acknowledgements: Bridging Science, Care, and Community – GHMJ (Global Health Management Journal), Volume 8, Number 2, 2025." GHMJ (Global Health Management Journal) 8, no. 2 (2025): 257–58. https://doi.org/10.35898/ghmj-821269.

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As the GHMJ (Global Health Management Journal) continues to advance integrated solutions for global health challenges, this edition highlights cutting-edge research and innovations spanning from molecular science to health systems strengthening. This issue of the Global Health Management Journal (Vol. 8, No. 2, 2025) presents an interconnected range of studies that reflect the dynamic challenges and innovations in global health. Beginning with clinical and pharmacological research, the issue highlights a study on radiographic patterns in tuberculosis patients with and without diabetes (Fatihah

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Bardia, Aditya, Peter Schmid, Nadia Harbeck, et al. "Abstract OT2-11-09: Lidera breast cancer: A phase III adjuvant study of giredestrant (GDC-9545) vs physician’s choice of endocrine therapy (ET) in patients (pts) with estrogen receptor-positive, HER2-negative early breast cancer (ER+/HER2- EBC)." Cancer Research 82, no. 4_Supplement (2022): OT2–11–09—OT2–11–09. http://dx.doi.org/10.1158/1538-7445.sabcs21-ot2-11-09.

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Abstract BACKGROUND ETs that target ER activity and/or estrogen synthesis are the mainstay of ER+ BC treatment. Despite best management, up to 20% of pts with ER+/HER2- eBC develop resistance (in some cases due to the acquisition of tumor mutations in ESR1 that can drive estrogen-independent transcription and proliferation) and still have high recurrence rates on standard ETs. New treatment alternatives for ER+/HER2- eBC are needed to reduce risk of recurrence and improve survival, tolerability, quality of life, and adherence. Giredestrant is a highly potent, nonsteroidal oral selective ER ant

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Joshua Ikenna Egerson, Idowu Oluwayoma Adeleke, Taiwo Akindahunsi, et al. "Data-driven approaches to tackling mental health." World Journal of Advanced Research and Reviews 23, no. 3 (2024): 001–16. http://dx.doi.org/10.30574/wjarr.2024.23.3.2638.

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Background: Over the past few years there has been immense evolution in various areas particularly in the areas of digital technologies wherein the pace of change is very high. Industrial areas such as operations and supply chain management together with advanced technologies such as machine learning, big data analytics, artificial intelligence, as well as the Internet of Things, create completely different forms of operational models for various industries. In the area of healthcare too, these emerging computational sophistication is introduced to revolutionise the approaches to prevent, diag

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Joshua, Ikenna Egerson, Oluwayoma Adeleke Idowu, Akindahunsi Taiwo, et al. "Data-driven approaches to tackling mental health." World Journal of Advanced Research and Reviews 23, no. 3 (2024): 001–16. https://doi.org/10.5281/zenodo.14908924.

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<strong>Background</strong>: Over the past few years there has been immense evolution in various areas particularly in the areas of digital technologies wherein the pace of change is very high. Industrial areas such as operations and supply chain management together with advanced technologies such as machine learning, big data analytics, artificial intelligence, as well as the Internet of Things, create completely different forms of operational models for various industries. In the area of healthcare too, these emerging computational sophistication is introduced to revolutionise the approaches

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Pili, Yuvensius, Roro Tutik Sri Hariyati, Hening Pujasari, and Cori Tri Suryani. "Program improvement kendali mutu dan kendali biaya pada pasien paliatif oleh kepala ruangan." Holistik Jurnal Kesehatan 18, no. 10 (2025): 1311–20. https://doi.org/10.33024/hjk.v18i10.579.

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Background: Transformation in healthcare in this digital era demands efficiency, hospitals must be able to balance between quality of service and operational costs. The healthcare sector is prone to inefficiencies such as unnecessary care, waste in healthcare, undesirable variations in clinical practice, administrative burden, fraud and abuse. Purpose: To explore the improvement program of quality control and cost control in palliative patients by the head of the room. Method: This mini research is in accordance with the process of data collection and literature study using questionnaires, obs

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Dimiccoli, Mariella, and Petia Radeva. "Visual Lifelogging in the Era of Outstanding Digitization." Digital Presentation and Preservation of Cultural and Scientific Heritage 5 (September 30, 2015): 59–64. http://dx.doi.org/10.55630/dipp.2015.5.4.

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In this paper, we give an overview on the emerging trend of the digitized self, focusing on visual lifelogging through wearable cameras. This is about continuously recording our life from a first-person view by wearing a camera that passively captures images. On one hand, visual lifelogging has opened the door to a large number of applications, including health. On the other, it has also boosted new challenges in the field of data analysis as well as new ethical concerns. While currently increasing efforts are being devoted to exploit lifelogging data for the improvement of personal well-being

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Schmid, Peter, Charles E. Geyer Jr, Nadia Harbeck, et al. "Abstract OT2-03-02: lidERA Breast Cancer: A phase III adjuvant study of giredestrant (GDC-9545) vs physician’s choice of endocrine therapy in patients with estrogen receptor+, HER2– early breast cancer." Cancer Research 83, no. 5_Supplement (2023): OT2–03–02—OT2–03–02. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot2-03-02.

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Abstract BACKGROUND Endocrine therapies (ETs) that target estrogen receptor (ER) activity and/or estrogen synthesis are the mainstay of ER+ breast cancer (BC) treatment. Despite best management, ≤20% of patients (pts) with ER+/HER2– early BC (eBC) develop resistance (in some cases due to acquisition of tumor mutations in ESR1 that can drive estrogen-independent transcription and proliferation) and still have high recurrence rates on standard ETs. New treatment alternatives for ER+/HER2– eBC are needed to reduce risk of recurrence and improve survival, tolerability, quality of life, and adheren

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Kojo, Kosuke. "Methods to Enhance Accessibility of Japanese Medical Literature in English Journals." JMA Journal 7, no. 4 (2024): 461–70. https://doi.org/10.31662/jmaj.2024-0140.

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Title <strong>Methods to Enhance Accessibility of Japanese Medical Literature in English Journals</strong> Abstract To address the challenges of accurately citing Japanese medical literature in English journals, the essential guidelines “Citing Medicine” by the National Library of Medicine were reviewed, focusing on practical adjustments to enhance accessibility. Key proposals include the use of persistent identifiers (Digital Object Identifier, PubMed Identifier, and International Standard Book Number), proper citation of online content, and the inclusion of romanized Japanese art

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Jatin, Chunawala Prachi, Chunawala Purvi Jatin, Shreya Singh Beniwal, et al. "Managing obstetric and gynecologic complications in obese women." Annals of Medicine & Surgery, April 15, 2025. https://doi.org/10.1097/ms9.0000000000003300.

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Introduction: Obesity among reproductive-aged women increases the risk of gestational diabetes, preeclampsia, menstrual disorders, infertility, and delivery complications. Despite rising global obesity rates, clinical guidelines often lack comprehensive management strategies. This review examines evidence-based approaches to optimize maternal and gynecologic outcomes through multidisciplinary care. Methods: A comprehensive literature review was conducted on obesity-related obstetric and gynecologic complications, including national and international guidelines, clinical trials, and observation

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Rivard, Lysanne, Pascale Lehoux, Robson Rocha de Oliveira, and Hassane Alami. "Thematic analysis of tools for health innovators and organisation leaders to develop digital health solutions fit for climate change." BMJ Leader, July 4, 2023, leader—2022–000697. http://dx.doi.org/10.1136/leader-2022-000697.

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ObjectivesWhile ethicists have largely underscored the risks raised by digital health solutions that operate with or without artificial intelligence (AI), limited research has addressed the need to also mitigate their environmental footprint and equip health innovators as well as organisation leaders to meet responsibility requirements that go beyond clinical safety, efficacy and ethics. Drawing on the Responsible Innovation in Health framework, this qualitative study asks: (1) what are the practice-oriented tools available for innovators to develop environmentally sustainable digital solution

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Wanten, Joukje C., Maartje H. M. Segers, Jos Kleijnen, Noël J. C. Bauer, and Rudy M. M. A. Nuijts. "Efficacy of Remote Care in Cataract Surgery: a Systematic Review." Journal of Cataract & Refractive Surgery, March 12, 2025. https://doi.org/10.1097/j.jcrs.0000000000001652.

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Topic: To evaluate the efficacy of currently available digital and remote care applications for postoperative cataract management compared to traditional methods for postoperative clinical measurements. Clinical relevance: With the increasing demand for ophthalmological services and an anticipated shortage of professionals, innovative approaches are needed to optimize care. Cataract surgery, characterized by its high safety profile and turnover rate, is well-suited for digital and remote care solutions, which could enhance the postoperative patient pathway, potentially leading to substantial t

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He, Wenle, Xuewei Wu, Zhe Jin, et al. "Generative artificial intelligence in medical imaging: Current landscape, challenges, and future directions." Interdisciplinary Medicine, May 15, 2025. https://doi.org/10.1002/inmd.20250024.

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AbstractThe clinical significance, digital attributes, and underlying high‐dimensional information in medical images make them a key area for the artificial intelligence (AI) revolution in health care. Generative AIs (GAIs) provide unprecedented abilities in synthesizing diverse and accurate simulated medical images for AI model training as well as personalized disease management. However, several hurdles must be overcome prior to clinical implementation, such as biases introduced during training in synthesized images and the risk of medical and research falsification. This review outlines the

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"Transformative Role of Artificial Intelligence in the Pharmaceutical Sector." Journal of Angiotherapy 8, no. 9 (2024): 1–8. http://dx.doi.org/10.25163/angiotherapy.899933.

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Background: The pharmaceutical sector is a critical component of healthcare, driving innovation in drug discovery, development, and delivery. With the increasing integration of artificial intelligence (AI), digital health technologies, and biotechnology, the industry is transforming rapidly. This review examines the key areas of the pharmaceutical industry and highlights the growing impact of AI in enhancing various processes, from drug discovery to clinical trials. To explore the applications of AI in drug discovery, development, manufacturing, clinical trials, personalized medicine, and regu

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Yu, Hang, Wei Zhang, Guoliang Li, et al. "Impact of digital health management on clinical outcomes during post-PCI outpatient care in patients with acute coronary syndrome: study protocol for a multicentre, randomized controlled trial." Frontiers in Cardiovascular Medicine 12 (May 20, 2025). https://doi.org/10.3389/fcvm.2025.1555544.

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IntroductionCoronary heart disease is becoming more common in developing nations. Acute coronary syndrome (ACS) poses a major challenge to global health; however, access to cardiac rehabilitation and preventative measures is limited. There is an urgent need for affordable and widely accessible alternative delivery models to resolve this treatment gap. Research conducted by both local and international experts has focused on the role of smartphones in offering rehabilitation guidance and secondary prevention for patients. Rehabilitative effects have mainly been observed in areas where risk fact

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Kyriazakos, Sofoklis, Aristodemos Pnevmatikakis, Konstantina Kostopoulou, et al. "Benchmarking the clinical outcomes of Healthentia SaMD in chronic disease management: a systematic literature review comparison." Frontiers in Public Health 12 (December 24, 2024). https://doi.org/10.3389/fpubh.2024.1488687.

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BackgroundSoftware as a Medical Device (SaMD) and mobile health (mHealth) applications have revolutionized the healthcare landscape in the areas of remote patient monitoring (RPM) and digital therapeutics (DTx). These technological advancements offer a range of benefits, from improved patient engagement and real-time monitoring, to evidence-based personalized treatment plans, risk prediction, and enhanced clinical outcomes.ObjectiveThe systematic literature review aims to provide a comprehensive overview of the status of SaMD and mHealth apps, highlight the promising results, and discuss what

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Henry, James Andrew. "Population health management genomic new-born screens and multi-omics intercepts." Frontiers in Artificial Intelligence 7 (August 1, 2025). https://doi.org/10.3389/frai.2024.1496942.

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IntroductionThe Population Health Management (PHM) Genomic Newborn Screens (GNBS) and Multi-Omics Intercepts for Human Phenotype Ontology (HPO) using Federated Data Platforms (FDP) represent a groundbreaking innovation in global health. This reform, supported by the UK’s Genomic Medical Services (GMS) through “The Generation Study,” aims to significantly reduce infant mortality by identifying and managing over 200 rare diseases from birth, paving the way for personalised health planning.MethodsUsing an ecosystem approach, this study evaluates a diverse pangenome to predict health outcomes or c

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Chen, Minghao, Valerie Sparkes, and Liba Sheeran. "Systematic review of digital health interventions to support self-management of low back pain in the workplace." DIGITAL HEALTH 11 (May 2025). https://doi.org/10.1177/20552076251336281.

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Background Low back pain (LBP) is a prevalent condition in working populations, imposing significant individual, organisational, and societal burdens, including reduced quality of life, impaired work performance, and high healthcare costs. Digital health interventions (DHIs) offer scalable solutions for self-managing LBP in workplace settings, yet their tailoring, integration, and effectiveness remain unclear. Objective This systematic review evaluates the effectiveness of DHIs in supporting LBP self-management in workplace environments. It examines intervention components, tailoring methods,

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Bradshaw, Angela, Nigel Hughes, David Vallez-Garcia, et al. "Data sharing in neurodegenerative disease research: challenges and learnings from the innovative medicines initiative public-private partnership model." Frontiers in Neurology 14 (July 20, 2023). http://dx.doi.org/10.3389/fneur.2023.1187095.

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Efficient data sharing is hampered by an array of organizational, ethical, behavioral, and technical challenges, slowing research progress and reducing the utility of data generated by clinical research studies on neurodegenerative diseases. There is a particular need to address differences between public and private sector environments for research and data sharing, which have varying standards, expectations, motivations, and interests. The Neuronet data sharing Working Group was set up to understand the existing barriers to data sharing in public-private partnership projects, and to provide

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Islam, Md Tawfiqul, Sabbir Ahmad, Md Anikur Rahman, and Md Arifur Rahaman. "NEURAL NETWORK–BASED RISK PREDICTION AND SIMULATION FRAMEWORK FOR MEDICAL IOT CYBERSECURITY: AN ENGINEERING MANAGEMENT MODEL FOR SMART HOSPITALS." International Journal of Scientific Interdisciplinary Research, June 1, 2024, 30–57. https://doi.org/10.63125/g0mvct35.

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The rapid digitalization of healthcare through the adoption of Medical Internet of Things (MIoT) technologies has given rise to smart hospital ecosystems that are highly efficient yet increasingly vulnerable to cybersecurity threats. As MIoT devices become integral to patient monitoring, diagnostics, and treatment, the risk of cyberattacks—ranging from ransomware and data breaches to insider threats and Distributed Denial of Service (DDoS) attacks—has grown substantially. In response, this study conducts a structured meta-analysis to evaluate the effectiveness of neural network–based risk pred

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Baptista, Alexandre, Ana Macedo, Ana Marreiros, and André Coelho. "Editor’s Pick – Characterising Drug-Associated Nephrolithiasis: Insights from Global Adverse Drug Reaction Database." European Medical Journal, June 12, 2025, 72–82. https://doi.org/10.33590/emj/uhej6955.

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Nojaba L, Guzman N. Nephrolithiasis (Kidney Stones) (Archived) [Internet] (2023) Treasure Island (FL): StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK559227/. Last accessed: 21 January 2024 Stamatelou K, Goldfarb DS. Epidemiology of kidney stones. Healthcare (Basel). 2023;11(3):424. Daudon M et al. Drug-induced kidney stones and crystalline nephropathy: pathophysiology, prevention and treatment. Drugs. 2018;78(2):163-201. Hara M et al. Atazanavir nephrotoxicity. Clin Kidney J. 2015;8(2):137-42. Dong BJ et al. Sulfadiazine-induced crystalluria and renal failure in a

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Huang, Yan, Ting Yang, Xiaoqin Liang, et al. "Global, regional and national trends in the burden of persistent pulmonary hypertension of the newborn and essentials of its management from 1993 to 2023: a scoping review." Frontiers in Pediatrics 13 (June 4, 2025). https://doi.org/10.3389/fped.2025.1502385.

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BackgroundPersistent pulmonary hypertension of the newborn (PPHN) is a frequent neonatal emergency in the neonatal intensive care unit (NICU), representing a challenging condition that has not been extensively studied. PPHNremains associated with a high mortality and morbidity.ObjectiveThis scoping review was undertaken to provide a global overview of several key aspects: (1) the prevalence/incidence and etiologies of PPHN, (2) the mortality rate linked to PPHN during hospitalization and the primary causes of such mortality, (3) the risk factors related to PPHN, and (4) the approaches to manag

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