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1

Liew, Su May. "The impact of treatment and time on cardiovascular risk scores." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:c7840ca1-f99a-472a-8a8b-aa7493504a3d.

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Cardiovascular risk scores predict an individual’s risk of developing cardiovascular disease. Many were developed and validated in study cohorts on risk-factor lowering treatment – a cause of inaccuracy. In addition, risk scores are criticised as being biased towards the elderly due to the prominence of age as a risk predictor. Although present guidelines advocate the use of short-term (5-10 year) absolute risk scores, other approaches to redress this perceived imbalance such as lifetime risk scores are being considered. The overall objective of this thesis is to identify the most appropriate
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2

Martínez, Millana Antonio. "ASSESSMENT OF RISK SCORES FOR THE PREDICTION AND DETECTION OF TYPE 2 DIABETES MELLITUS IN CLINICAL SETTINGS." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/86209.

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Health and sociological indicators confirm that life expectancy is increasing, and so, the years that patients have to live with chronic diseases and co-morbidities. Type 2 Diabetes is one of the most common chronic diseases, specially linked to overweight and ages over sixty. As a metabolic disease, Type 2 Diabetes affects multiple organs by causing damage in blood vessels and nervous system at micro and macro scale. Mortality of subjects with diabetes is three times higher than the mortality for subjects with other chronic diseases. On the one hand, the management of diabetes is focused on
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3

Koechlin, Kathleen Marie. "Modeling childhood agricultural injury risk with composite measurement scales." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5num=osu1064287970.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xxi, 308 p. : ill. (some col.). Advisor: J.R. Wilkins III, School of Public Health. Includes bibliographical references (p. 210-220).
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4

Shen, Hanyang, Bizu Gelaye, Hailiang Huang, Marta B. Rondon, Sixto Sanchez, and Laramie E. Duncan. "Polygenic prediction and GWAS of depression, PTSD, and suicidal ideation/self-harm in a Peruvian cohort." Springer Nature, 2020. http://hdl.handle.net/10757/652459.

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Genome-wide approaches including polygenic risk scores (PRSs) are now widely used in medical research; however, few studies have been conducted in low- and middle-income countries (LMICs), especially in South America. This study was designed to test the transferability of psychiatric PRSs to individuals with different ancestral and cultural backgrounds and to provide genome-wide association study (GWAS) results for psychiatric outcomes in this sample. The PrOMIS cohort (N = 3308) was recruited from prenatal care clinics at the Instituto Nacional Materno Perinatal (INMP) in Lima, Peru. Three ma
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Privé, Florian. "Genetic risk score based on statistical learning Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr Efficient implementation of penalized regression for genetic risk prediction Making the most of Clumping and Thresholding for polygenic scores." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAS024.

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Le génotypage devient de moins en moins cher, rendant les données de génotypes disponibles pour des millions d’individus. Par ailleurs, l’imputation permet d’obtenir l’information génotypique pour des millions de positions de l’ADN, capturant l’essentiel de la variation génétique du génome humain. Compte tenu de la richesse des données et du fait que de nombreux traits et maladies sont héréditaires (par exemple, la génétique peut expliquer 80% de la variation de la taille dans la population), il est envisagé d’utiliser des modèles prédictifs basés sur l’information génétique dans le cadre d’un
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Rice, Janice. "Assessing Suicide Risk Scores as a Predictor of Suicidal Behaviors in a Correctional Psychiatric Facility." Antioch University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1438219998.

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7

Yan, Jia. "Using Genetic Information in Risk Prediction for Alcohol Dependence." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2878.

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Family-based and genome-wide association studies (GWAS) of alcohol dependence (AD) have reported numerous associated variants. The clinical validity of these variants for predicting AD compared to family history has not yet been reported. These studies aim to explore the aggregate impact of multiple genetic variants with small effect sizes on risk prediction in order to provide a clinical interpretation of genetic contributions to AD. Data simulations showed that given AD’s prevalence and heritability, a risk prediction model incorporating all genetic contributions would have an area under the
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8

Wood, Anthony Paul. "The performance of insolvency prediction and credit risk models in the UK : a comparative study, development and wider application." Thesis, University of Exeter, 2012. http://hdl.handle.net/10036/4211.

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Contingent claims models have recently been applied to the field of corporate insolvency prediction in an attempt to provide the art with a theoretical methodology that has been lacking in the past. Limited studies have been carried out in order to empirically compare the performance of these “market” models with that of their accounting number-based counterparts. This thesis contributes to the literature in several ways: The thesis traces the evolution of the art of corporate insolvency prediction from its inception through to the present day, combining key developments and methodologies into
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9

Molnar, Amber. "Predicting Graft Loss Following Acute Kidney Injury in Patients With a Kidney Transplant." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34236.

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Acute kidney injury (AKI), characterized by an abrupt loss of kidney function with retention of nitrogenous waste products, is common in the months to years following kidney transplantation and is associated with an increased risk of transplant failure (graft loss). Kidney transplant patients who experience graft loss and return to dialysis have an increased mortality risk and a lower quality of life. Research involving kidney transplant patients can prove challenging, as they are relatively small in number. To increase statistical power, researchers may utilize administrative databases. Howev
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10

Lluís, Ganella Carla 1984. "Genetic factors associated with coronary heart disease and analysis of their predictive capacity." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/84185.

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The main expansion of the discovery of genetic variants associated with complex diseases has occurred during the last decade. This expansion has been accompanied, and in some sense motivated, by the desire to use this information to improve the predictive capacity of many diseases with an unidentified familial component, including coronary heart disease (CHD), with the aim of translating this genetic knowledge into clinical practice. This doctoral thesis is structured in two lines of investigation that address distinct aspects of this issue, first to evaluate the possible role of genetic varia
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11

El, Hajj Maya. "Elaboration d'un Score Prédictif des Accidents Vasculaires Cérébraux au Liban." Thesis, Paris Est, 2017. http://www.theses.fr/2017PESC0078/document.

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Background : L’accident Vasculaire Cérébral (AVC) est la deuxième cause de décès au Liban et dans le monde. Il existe une pénurie d'informations fiables concernant l'épidémiologie de l'AVC au Liban. L’objectif de cette étude est d’identifier les facteurs de risque et les symptômes d'AVC dans la population libanaise et de développer un score pour la future prédiction de l'AVC et un score pour le diagnostic de l'AVC en situation d'urgence.Méthodes : Une étude cas-témoin a été menée pour la génération des scores. Les données ont été collectées à l’aide d’une fiche de collecte de données conçue da
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Bachlechner, Ursula [Verfasser], Heiner [Akademischer Betreuer] Boeing, Reinhard [Gutachter] Busse, and Heiner [Gutachter] Boeing. "Derivation and validation of German risk scores predicting substantial gain in weight and waist circumference / Ursula Bachlechner ; Gutachter: Reinhard Busse, Heiner Boeing ; Betreuer: Heiner Boeing." Berlin : Technische Universität Berlin, 2016. http://d-nb.info/1156271967/34.

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13

Lucio, Kellen Cristiane do Vale [UNESP]. "Avaliação do ROPScore como preditor de retinopatia da prematuridade em neonatos prematuros de muito baixo peso: estudo coorte." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/148931.

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Submitted by KELLEN CRISTIANE DO VALE LUCIO LUCIO (kellen.lucio@gmail.com) on 2017-03-03T19:39:59Z No. of bitstreams: 1 Dissertação final kellen.pdf: 3714896 bytes, checksum: 1f584543e024419a56cafffd8ec295b7 (MD5)<br>Approved for entry into archive by LUIZA DE MENEZES ROMANETTO (luizamenezes@reitoria.unesp.br) on 2017-03-08T20:28:01Z (GMT) No. of bitstreams: 1 lucio_kcv_me_bot.pdf: 3714896 bytes, checksum: 1f584543e024419a56cafffd8ec295b7 (MD5)<br>Made available in DSpace on 2017-03-08T20:28:01Z (GMT). No. of bitstreams: 1 lucio_kcv_me_bot.pdf: 3714896 bytes, checksum: 1f584543e024419a56ca
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Lucio, Kellen Cristiane do Vale. "Avaliação do ROPScore como preditor de retinopatia da prematuridade em neonatos prematuros de muito baixo peso estudo coorte /." Botucatu, 2017. http://hdl.handle.net/11449/148931.

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Orientador: Eliane Chaves Jorge<br>Resumo: Introdução e Objetivo: A Retinopatia da prematuridade (ROP) é a principal causa de deficiência visual permanente na infância. A identificação precoce da forma grave da ROP pode prevenir a cegueira. O ROPScore é um sistema de pontuação desenvolvido para otimizar a triagem e calcular o risco de ROP em neonatos pré-termo. Este estudo objetivou avaliar a acurácia deste algoritmo como preditor de ROP em uma coorte brasileira. Métodos: Realizou-se um estudo coorte prospectivo de 220 neonatos pré-temo com PN ≤1500 g e / ou IG ≤ 32 semanas. O ROPScore foi apl
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15

Schwarzbold, Alexandre Vargas. "Modelagem de um escore de mielotoxicidade quimioterápica na predição de neutropenia febril em tumores hematológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/16362.

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A neutropenia induzida pela quimioterapia é o mais comum efeito adverso da quimioterapia sistêmica para o câncer e é frequentemente complicada por neutropenia febril (NF). O uso profilático de fatores de crescimento hematopoiéticos pode reduzir o risco, a severidade e a duração da NF. Na prática clínica atual, a decisão de administrar ao paciente profilaxia com fatores de crescimento é baseada principalmente no potencial mielotóxico dos esquemas de QT, mas riscos específicos dos regimes não são definidos. Em muitos estudos, a toxicidade da quimioterapia é analizada em termos de alta dosagem ve
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16

Gopu, Anusharani. "Using non-medical risk factors related to dementia and cognitive decline for developing an evidencebased e-health tool." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-199191.

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The number of dementia cases is increasing worldwide. Most research and development in this area is related to the prevention of dementia, and to the development of various prediction tools for dementia. The tools made available take most of the medical data into account while calculating risk scores, with only a small amount of non-medical data. There is a lot of data related to medical and non-medical risk factors available from various sources which can be retrieved and analysed in real time, but this is today not used in any risk score tool for risk score calculation. As part of the projec
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17

Steffen, Annika [Verfasser], and Reinhard [Akademischer Betreuer] Busse. "Development and Validation of a Risk Score predicting substantial Weight Gain over 5 Years in middle-aged European Men and Women / Annika Steffen. Betreuer: Reinhard Busse." Berlin : Universitätsbibliothek der Technischen Universität Berlin, 2012. http://d-nb.info/1019595256/34.

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18

Simões, Heitor do Amaral. "Avaliação do ROPScore como preditor de retinopatia da prematuridade em neonatos prematuros. Estudo comparativo." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/157199.

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Submitted by HEITOR DO AMARAL SIMOES (heitor.simoes@unesp.br) on 2018-09-13T01:17:04Z No. of bitstreams: 1 MEPAREM - Heitor do Amaral Simoes - Avaliação do ROPScore como preditor de retinopatia da prematuridade em neonatos prematuros. Estudo Comparativo.pdf: 1887030 bytes, checksum: 2e9cfdf0558f9a8d0105c14a99fd67ad (MD5)<br>Rejected by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br), reason: Solicitamos que realize uma nova submissão seguindo as orientações abaixo: problema 1: Númeração das folhas As folhas pré-textuais são contadas mas não numeradas. A inclusão da numeraçã
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19

Blanche, Paul. "Contribution à l'évaluation de capacités pronostiques en présence de données censurées, de risques concurrents et de marqueurs longitudinaux : inférence et applications à la prédiction de la démence." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22098/document.

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Ce travail a eu pour objectif de proposer des méthodes statistiques pour évaluer et comparer les capacités prédictives de divers outils pronostiques. Le Brier score et principalement les courbes ROC dépendant du temps ont été étudiés. Tous deux dépendent d'un temps t, représentant un horizon de prédiction. Motivé par les applications à la prédiction de la démence et des données de cohortes de personnes âgées, ce travail s'est spécifiquement intéressé à des procédures d'inférence en présence de données censurées et de risques concurrents. Le risque concurrent de décès sans démence est en effet
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20

Narbey, David. "Epidémiologie des hémolyses post transfusionnelles retardées chez les patients drépanocytaires adultes : incidence, facteurs de risque et construction d’un score prédictif." Thesis, Paris Est, 2017. http://www.theses.fr/2017PESC0017.

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L’hémolyse post transfusionnelle retardée (HPTR) est une complication potentiellement mortelle de la transfusion dans la drépanocytose. Sa fréquence est sous-estimée et aucun facteur prédictif de sa survenue n'a encore été identifié. Nous avons mené une étude observationnelle prospective monocentrique pendant 30 mois. Nous avons inclus 694 épisodes transfusionnels (ET) chez 311 patients adultes drépanocytaires, divisés en ET ponctuels (ETP = 360) et en ET chronique dans le cadre d’un programme (ETC = 334). Au cours de ce suivi, 15 HPTR ont été enregistrées, exclusivement après un ETP. L'incide
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Fouayzi, Hassan. "Using Healthcare Data to Inform Health Policy: Quantifying Cardiovascular Disease Risk and Assessing 30-Day Readmission Measures." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1031.

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Health policy makers are struggling to manage health care and spending. To identify strategies for improving health quality and reducing health spending, policy makers need to first understand health risks and outcomes. Despite lacking some desirable clinical detail, existing health care databases, such as national health surveys and claims and enrollment data for insured populations, are often rich in information relating patient characteristics to heath risks and outcomes. They typically encompass more inclusive populations than can feasibly be achieved with new data collection and are valua
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Costa, Federico. "Estudos ecológicos sobre reservatórios urbanos de leptospirose em Salvador." reponame:Repositório Institucional da FIOCRUZ, 2010. https://www.arca.fiocruz.br/handle/icict/4194.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-07-18T19:29:56Z No. of bitstreams: 1 Federico Costa EStudos ecológicos sobre reservatórios....pdf: 1462379 bytes, checksum: 12cd0ac366f256448b7800dbac8ca53a (MD5)<br>Made available in DSpace on 2012-07-18T19:29:56Z (GMT). No. of bitstreams: 1 Federico Costa EStudos ecológicos sobre reservatórios....pdf: 1462379 bytes, checksum: 12cd0ac366f256448b7800dbac8ca53a (MD5) Previous issue date: 2010<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>A leptospirose é um importante proble
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Vernerey, Dewi. "Méthodologie statistique pour la prédiction du risque et la construction de score pronostique en transplantation rénale et en oncologie : une pierre angulaire de la médecine de précision." Thesis, Besançon, 2016. http://www.theses.fr/2016BESA3004/document.

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Le pronostic est depuis longtemps un concept de base de la médecine. Hippocrate envisageait déjà le pronostic des maladies par l’étude des circonstances passées, l’établissement des faits présents, et enfin la prédiction des phénomènes à venir. Pour lui, tout l’art du pronostic était de savoir interpréter intelligemment ces informations, et ainsi moduler le pronostic en fonction de leur valeur relative. Une recherche à visée pronostique consiste toujours actuellement en l’examen des relations entre un état de santé connu au moment de l’investigation et un évènement futur. L’augmentation de l’e
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24

Leneuve, Dorilas Malika. "Les facteurs de risque de la naissance prématurée en Guyane Française Rosk factors for premature birth in French Guiana: the importance of reducing health inegalities Predictive factors of preterms delivery in French Guiana for singleton pregnancies: definition and validation of a predictive score Risk Factors for Very Preterm Births in French Guiana : The Burden of Induced Preterm Birth African ancestry and the threshold defining preterm delivery: in French Guiana black babies born at 36 weeks are as vulnerable as white babies." Thesis, Guyane, 2019. http://www.theses.fr/2019YANE0003.

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Contexte et objectif : La Guyane Française, département-région d’outre-mer, compte près de 8 000 naissances par année.Depuis 1992, la proportion de naissances prématurées y est importante aux alentours de 13,5% ; soit presque le double de celle de la France (7%). Contrairement à la plupart des pays où une augmentation de la prématurité est observée, en Guyane, son taux est stable. Certes, on pourrait se satisfaire de cette non-augmentation, cependant, les décès liés à la périnatalité restent l’une des principales causes de mortalité prématurée dans ce département. Si en Guyane, le taux de prém
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25

Wang, Jen-Way, and 王禎蔚. "Financial Prediction, Credit Scores, Distance to Default and Systematic Risk in Taiwan’s OTC Market." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/02210564199960404524.

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碩士<br>朝陽科技大學<br>保險金融管理系碩士班<br>98<br>Global financial crisis made financial institution fail and corporation default. The crisis also shrinks investors’ assets and hurts their confidence. The paper based on TEJ’s database, which includes stock index、market value、price、D/E ratio and risk-free interest rate, since Jan 1992 to Dec 2008. Based on the data, I use default distance and Z-Score by Merton model as independent variables, and calculate the related. After that, I use these variables to establish a financial crisis forecast model. In conclusion, Z-score can precisely forecast default possi
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26

Jarvis, S. W., C. Kovacs, T. Badriyah, et al. "Development and validation of a decision tree early warning score based on routine laboratory test results for the discrimination of hospital mortality in emergency medical admissions." 2013. http://hdl.handle.net/10454/9783.

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No<br>To build an early warning score (EWS) based exclusively on routinely undertaken laboratory tests that might provide early discrimination of in-hospital death and could be easily implemented on paper. Using a database of combined haematology and biochemistry results for 86,472 discharged adult patients for whom the admission specialty was Medicine, we used decision tree (DT) analysis to generate a laboratory decision tree early warning score (LDT-EWS) for each gender. LDT-EWS was developed for a single set (n=3496) (Q1) and validated in 22 other discrete sets each of three months long (Q2
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Ghorbani, Mojarrad Neema, C. Williams, and J. A. Guggenheim. "A genetic risk score and number of myopic parents independently predict myopia." 2018. http://hdl.handle.net/10454/17505.

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Yes<br>Purpose: To investigate whether a genetic risk score (GRS) improved performance of predicting refractive error compared to knowing a child’s number of myopic parents (NMP) alone. Methods: This was a retrospective analysis of data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort study. Refractive error was assessed longitudinally between age 7–15 using non-cycloplegic autorefraction. Genetic variants (n=149) associated with refractive error from a Consortium for Refractive Error And Myopia (CREAM) genome-wide association study were used to calculate a GRS fo
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28

Petz, Thomas. "T-Score Model. A default prediction model for software companies." Thesis, 2003. http://epub.wu.ac.at/1916/1/document.pdf.

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The dissertation deals with credit risk and default prediction for software companies in the light of Basel II, the new capital accord for financial institutions. A credit risk model was developed which can be used by lenders to predict the default of software companies. Such model was developed by using three independent approaches: In a first approach, a model was created which was based solely on quantitative data (i.e. accounting data). In a second approach, a model was developed which was based entirely on qualitative information, including management skills, know how, quality of services
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Pereira, Andreia Micaela de Sousa. "Componente genético da doença coronária e interação com os fatores de risco tradicionais." Doctoral thesis, 2018. http://hdl.handle.net/10362/43066.

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ABSTRACT: The utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction. A total of 2888 individuals (1566 coronary patients and 1322 controls) were divided in three subgroups according to FRS. Multiplicative GRS was determined for 32 genetic variants associated to CAD. Logistic Regression and Area Under the Curve (AUC) were determined first using the TRF for each FRS subgroup and secondly adding GRS. Different models (TRF
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SUNG, CHEN-MING, and 宋振明. "Comparison of Bone Mineral Density and Trabecular Bone Score in The Prediction of Fracture Risk." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/36fef3.

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碩士<br>元培醫事科技大學<br>醫學影像暨放射技術系碩士班<br>106<br>With the aging of the world population, osteoporosis has become an important public health issue. Bone mineral density (BMD) is usually considered as an effective predictor of the risk of osteoporotic fracture by using dual-energy x-ray absorptiometry (DXA). Trabecular bone score (TBS) is a novel analysis tool to assess trabecular microarchitecture for the prediction of fracture risk. The purpose of this study was to compare the efficacy of two analysis techniques (BMD vs. TBS) in the assessment of fracture risk and to determine the appropriate cut-off
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Faisal, Muhammad, Andy J. Scally, D. Richardson, et al. "Development and external validation of an automated computer-aided risk score for predicting sepsis in emergency medical admissions using the patient’s first electronically recorded vital signs and blood test results." 2017. http://hdl.handle.net/10454/14800.

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Yes<br>Objectives: To develop a logistic regression model to predict the risk of sepsis following emergency medical admission using the patient’s first, routinely collected, electronically recorded vital signs and blood test results and to validate this novel computer-aided risk of sepsis model, using data from another hospital. Design: Cross-sectional model development and external validation study reporting the C-statistic based on a validated optimized algorithm to identify sepsis and severe sepsis (including septic shock) from administrative hospital databases using International Classi
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Ho, Chi-Hsien, and 何紀賢. "Development of a Risk Score for Predicting Hepatotoxicity during HMG-CoA Reductase Inhibitors Therapy in Diabetic Patients." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/55146476990938941063.

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碩士<br>臺北醫學大學<br>藥學研究所<br>96<br>HMG-CoA reductase inhibitors (statins)-induced hepatotoxicity is a common adverse effect characterized by asymptomatic and transient elevations in liver enzymes. Due to the self-resolving nature, even without statin discontinuation, the frequency of monitoring of liver function tests (LFT) in patients receiving statin therapy is usually lower than the manifacturers’ recommendations. Although hepatotoxicity is rarely severe, once it occurs, patients are endangered directly by the event itself and indirectly from lowered patient compliance. Hyperlipidemia and liver
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Dyson, J., C. Marsh, N. Jackson, et al. "Understanding and applying practitioner and patient views on the implementation of a novel automated Computer-Aided Risk Score (CARS) predicting the risk of death following emergency medical admission to hospital: qualitative study." 2019. http://hdl.handle.net/10454/17030.

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Yes<br>Objectives The Computer-Aided Risk Score (CARS) estimates the risk of death following emergency admission to medical wards using routinely collected vital signs and blood test data. Our aim was to elicit the views of healthcare practitioners (staff) and service users and carers (SU/C) on (1) the potential value, unintended consequences and concerns associated with CARS and practitioner views on (2) the issues to consider before embedding CARS into routine practice. Setting This study was conducted in two National Health Service (NHS) hospital trusts in the North of England. Both had
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Lai, Shiau-Ting, and 賴筱婷. "Do we need additional markers in predicting metabolic syndrome? A risk score approach in testing six physical and biochemical indices." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/19639120798987055512.

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碩士<br>中山醫學大學<br>公共衛生學系碩士班<br>104<br>Research purposes: In this study, long-term large-scale data tracking, and scan a variety of possible biochemical indicators (related to liver and kidney function indicators, including GOT, GPT, blood uric acid), and controls the important demographic variables, in order to define the importance of the relationship between various biochemical indicators. In this study, the metabolic syndrome associated with common blood biochemical indices for discussion. Materials and Methods: This study was a prospective cohort study using landseed hospital data collecte
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Faisal, Muhammad, A. Mohammed Mohammed, D. Richardson, E. W. Steyerberg, M. Fiori, and K. Beatson. "Predictive accuracy of enhanced versions of the on-admission National Early Warning Score in estimating the risk of COVID-19 for unplanned admission to hospital: a retrospective development and validation study." 2021. http://hdl.handle.net/10454/18599.

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Yes<br>The novel coronavirus SARS-19 produces 'COVID-19' in patients with symptoms. COVID-19 patients admitted to the hospital require early assessment and care including isolation. The National Early Warning Score (NEWS) and its updated version NEWS2 is a simple physiological scoring system used in hospitals, which may be useful in the early identification of COVID-19 patients. We investigate the performance of multiple enhanced NEWS2 models in predicting the risk of COVID-19. Our cohort included unplanned adult medical admissions discharged over 3 months (11 March 2020 to 13 June 2020 ) fro
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Hezoučká, Šárka. "Modely predikce defaultu klienta." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-305122.

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The aim of the presented work is to investigate possible improvement of scor- ing models prediction power in retail credit segment by using structural models estimating the future development of behavioral score. These models contain the information about past development of the behavioral score by parameters which take into account the sensitivity of clients' probability of default on in- dividual market and life changes. These parameters are estimated with Markov Chain Monte Carlo methods based on score history. Eight different types of struc- tural models were applied on the real data. The
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Hezoučká, Šárka. "Modely predikce defaultu klienta." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-341935.

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The aim of this thesis is to investigate possible improvement of scoring models prediction power in retail credit segment by using structural models estimating the future development of behavioral score. These models contain the informa- tion about past development of the behavioral score by parameters which take into account the sensitivity of clients' probability of default on individual market and life changes. These parameters are estimated by Markov Chain Monte Carlo methods based on score history. Eight different types of structural models were applied to real data. The diversification m
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Santucci, Lara. "Évaluation de nouvelles méthodes de prédiction et de dépistage précoce de l’albuminurie chez les patients avec diabète de type 2." Thesis, 2019. http://hdl.handle.net/1866/24507.

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Le diabète de type 2 (DT2) est une maladie chronique grave et sa prévalence ne cesse d’augmenter partout dans le monde. La complication la plus sévère et la plus courante du diabète est la néphropathie diabétique dont le premier symptôme est l’albuminurie. Notre premier objectif est d’évaluer si un dépistage précoce de l’albuminurie permet une meilleure prise en charge de cette complication dans la pratique générale des médecins. Notre deuxième objectif est de valider l’efficacité de notre score de risque polygénique (SRP) sur la prédiction du risque d’albuminurie sur une cohorte canadienne co
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Mosalakae, Isaiah Gaabalwe Bojosinyana. "Financial performance measurement of South Africa's top companies: an exploratory investigation." Thesis, 2007. http://hdl.handle.net/10500/1264.

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This study explores the financial performance measurement of South Africa's Top Companies. It aims to find a conclusion on the research problem, that is 'Do South Africa's Top Companies use the available arsenal to measure their financial performance?' Commerce and industry are the cornerstones of the economy of a country. This study purports to contribute to the ways and means of minimising the risk of business failures due to the resultant effects on the economy. The sample comprises of sixty companies. The sampling frame is the first hundred companies of the Financial Mail 200 Top Perfo
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McCanna, David. "Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products." Thesis, 2009. http://hdl.handle.net/10012/4338.

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The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe t
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