Log in

Relevant bibliographies by topics / RLF receptor / Dissertations / Theses

To see the other types of publications on this topic, follow the link: RLF receptor.

Dissertations / Theses on the topic 'RLF receptor'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'RLF receptor.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Nasa, Zeyad, and nasa zeyad@med monash edu au. "Characterization of the Rat Relaxin-like Factor Gene." RMIT University. Medical Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080514.100729.

Full text

Abstract:

Relaxin-like factor (RLF), also known as Leydig insulin-like peptide (Ley-I-L) or Insulin 3 (INSL3), is a newly characterized member of the insulin peptide family. Amino acid sequence homology revealed that RLF is more closely related to relaxin than any other insulin-like hormones. The main aim of this thesis was to sequence the rat RLF (Relaxin-like factor) gene and determine the structure and organisation of the gene. Secondly to compare the structural organisation of the rat RLF/JAK3 genomic region with that of the mouse and human, using bioinformatic databases. Thirdly to further inves

APA, Harvard, Vancouver, ISO, and other styles

2

Restrepo, Montoya Daniel. "Computational Identification, Phylogenetic and Synteny Analysis of Receptor-Like Kinases “RLK” and Receptor-Like Proteins “RLP” in Legumes." Diss., North Dakota State University, 2018. https://hdl.handle.net/10365/29870.

Full text

Abstract:

Legumes are considered the second most important family of crop plants after the grass family based on economic relevance. In recent years, the field of legume genomics has expanded due to advancements in high-throughput sequencing and genotyping technologies. To date, no published comparative genomic analysis explores receptor-like kinases “RLK” and receptor-like proteins “RLP” among legume genomes. Evaluating these RLK and RLP should provide a source of new information because extensive genetic and phenotypic studies have already discovered the diverse roles of RLK and RLP in cell developmen

APA, Harvard, Vancouver, ISO, and other styles

3

Marcu, Jahan Phillip. "Novel Insights into CB1 Receptor Signaling and the Anabolic Role of Cannabinoid Receptors in Bone." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/233543.

Full text

Abstract:

Cell Biology<br>Ph.D.<br>Activation of the CB1 receptor is modulated by aspartate residue D2.63176 in transmembrane helix (TMH) II. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB1 receptor. Studies in class A GPCRs have suggested an ionic interaction between residues of TMHII and VII. In this report, modeling studies identified residue K373, in the extracellular (EC)-3 loop, in charged interactions with D2.63. We investigated this possibility by performing reciprocal mutations and biochemical studies. D2.63176A, K373A, D2.63176A-K373A, and the reciprocal mutant

APA, Harvard, Vancouver, ISO, and other styles

4

Tumati, Suneeta. "Functional regulation of opioid receptor signaling." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194989.

Full text

Abstract:

Studies have shown that long-term opioid agonist (such as morphine) treatment produces antinociceptive tolerance and increased pain sensitivity (hyperalgesia and/or allodynia), limiting the clinical efficacy of morphine. Prolonged opiate administration also upregulates spinal pain neurotransmitter (such as calcitonin gene-related peptide (CGRP)) levels and enhances evoked CGRP release in the dorsal horn of rats. It was suggested that augmented spinal pain neurotransmission may contribute to paradoxical pain sensitization and antinociceptive tolerance. The cellular signal transduction pathways

APA, Harvard, Vancouver, ISO, and other styles

5

Chiu, Yi-Ting. "STUDIES ON NEURITE OUTGROWTH AND RECEPTOR PHOSPHORYLATION FOLLOWING KAPPA OPIOID RECEPTOR ACTIVATION." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/384383.

Full text

Abstract:

Pharmacology<br>Ph.D.<br>Kappa opioid receptor (KOPR) is involved in many physiological functions and pharmacological responses such as analgesia, anti-pruritic effect, sedation, motor incoordination and aversion (Simonin et al., 1998; Liu-Chen, 2004). The cellular mechanisms following activation of KOPR involve in part Gi/o protein-dependent pathways (Law et al., 2000). Following KOPR activation, the receptor is phosphorylated and arrestins are recruited. Arrestins mediate agonist-dependent KOPR desensitization, internalization and down-regulation (Liu-Chen, 2004). In recent years, arrestins

APA, Harvard, Vancouver, ISO, and other styles

6

Dressano, Keini. "Interação do AtRALF1 com o receptor quinase1 associado ao BRI1 (BAK1)." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-26052015-164356/.

Full text

Abstract:

Os peptídeos hormonais vegetais, que vêm sendo caracterizados em plantas desde a década de 90, podem estar relacionados com defesa, reprodução, crescimento e desenvolvimento de plantas. O peptídeo RALF (Rapid Alkalinization Factor), ubíquo no reino vegetal, está envolvido com o desenvolvimento de plantas. Em arabidopsis há 37 genes que codificam peptídeos RALF (AtRALFs). A isoforma mais estudada é a AtRALF1, a qual regula de maneira negativa a expansão celular, inibindo o crescimento de raiz primária e o alongamento de hipocótilo quando aplicado exogenamente. Recentemente, demonstrou-se a exis

APA, Harvard, Vancouver, ISO, and other styles

7

Fu, Hangfei. "Interleukin 35 inhibits ischemia-induced angiogenesis essentially through the key receptor subunit Interleukin 12 receptor beta 2." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/546609.

Full text

Abstract:

Biomedical Sciences<br>Ph.D.<br>Peripheral arterial disease (PAD) is a worldwide disease caused by atherosclerosis. It is a circulatory condition where narrowed blood vessels reduce blood flow to the peripheral such as legs. Although current gold standard treatment for advanced PAD patients is still based on surgical revascularization, there is no effective therapy for many patients that are not suitable for surgery. In addition, better recovery from surgical revascularization largely relies on angiogenesis in the adjacent ischemic tissue. Thus, novel pro-angiogenic therapies to improve post-i

APA, Harvard, Vancouver, ISO, and other styles

8

Bryan, Anthony C. "Social Networks of Receptor-like Kinases Regulate Cell Identity in Arabidopsis thaliana." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/205180.

Full text

Abstract:

Receptor-like kinases (RLKs) make up one of the largest gene families in Arabidopsis thaliana. These genes are required for various biological processes, including response to biotic stress, cell elongation, cell proliferation, and cell fate patterning. An emerging theme in Arabidopsis and other plants is that networks of RLKs are required to regulate a specific process throughout development involving spatial and temporal regulation of transcription factors. However, there are still many RLKs (>50%) with no known function.Several RLKs regulate epidermal development by contributing to early em

APA, Harvard, Vancouver, ISO, and other styles

9

Geider, Kirsten [Verfasser], Bodo [Akademischer Betreuer] Laube, and Ralf [Akademischer Betreuer] Galuske. "Ionotropic glutamate receptor dysfunction in pediatric neurodevelopment / Kirsten Geider. Betreuer: Bodo Laube ; Ralf Galuske." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2015. http://d-nb.info/1110981228/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Inan, Saadet. "Pharmacological and Neuroanatomical Analysis of GNTI-Induced Repetitive Behavior in Mice." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/75332.

Full text

Abstract:

Pharmacology<br>Ph.D.<br>This thesis is comprised of two parts. In the first part, we investigated a) the pharmacology of GNTI, a selective kappa opioid receptor antagonist, as a scratch-inducing compound in mice and b) possible mediators and receptors that may be involved in GNTI-induced scratching (itch). We studied if GNTI induces scratching through opioid, histamine, gastrin-releasing peptide (GRP) and/or muscarinic M1 receptors. In the second part, we established similarities and differences between pain and itch using GNTI-induced scratching and formalin-induced nociception models in mic

APA, Harvard, Vancouver, ISO, and other styles

11

DiMattio, Kelly Marie. "Studies on Ligands of the Kappa Opioid Receptor." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/334919.

Full text

Abstract:

Pharmacology<br>Ph.D.<br>This thesis is comprised of three parts. In the first part, we investigated zyklophin, a novel selective short-acting kappa opioid receptor (KOPR) antagonist, and its effects on scratching behaviors in Swiss-Webster mice. We investigated whether zyklophin was able to induce scratching in a dose-dependent fashion, and whether this scratching behavior could be blocked by pretreatment with nor-binaltorphimine (norBNI). We also used KOPR -/- mice to further clarify the role of the KOPR in this behavior. In the second part, we examined the role of the divergent amino acid a

APA, Harvard, Vancouver, ISO, and other styles

12

McDevitt, Jane K. "N-METHYL-D-ASPARTIC ACID RECEPTOR SUBUNIT NR2A REPEAT." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216597.

Full text

Abstract:

Kinesiology<br>Ph.D.<br>During a concussion, mechanical forces cause neuron cell strain that initiates dysfunction through the indiscriminate movement of ions through protein channels. Extracellular glutamate binds with cell membrane proteins (e.g. NR2A), which exacerbates the Ca2+ ion influx and prolongs neuron dysfunction. Genetic variation may be a factor in regulating glutamate binding and therefore cell recovery time. The NR2A subunit of NMDA contains a variable (GT)n nucleotide tandem repeat (VNTR) within GRIN2A promoter region. This VNTR has been shown to regulate transcription levels i

APA, Harvard, Vancouver, ISO, and other styles

13

Huang, Xiaofang. "Functional study of amylin and regulation of amylin receptor." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/114036.

Full text

Abstract:

Pharmacology<br>Ph.D.<br>Amylin, a 37 amino acid peptide secreted from pancreatic beta cells upon stimulation by meal/glucose, belongs to the family of the calcitonin or calcitonin gene-related peptide (CGRP) and shares up to 50% homology with CGRP, which is a well-documented pain-related peptide. The amylin receptor is composed of a calcitonin receptor (CTR) and receptor activity modifying proteins (RAMPs). Numerous studies have shown that amylin plays an important role in glucose homeostasis and food intake. Few studies have been conducted with respect to the effect of amylin in the central

APA, Harvard, Vancouver, ISO, and other styles

14

Deliu, Elena. "GPER/GPR30 Estrogen Receptor: A Target for Pain Modulation." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/194862.

Full text

Abstract:

Pharmacology<br>Ph.D.<br>The G protein-coupled estrogen receptor GPER/GPER1, also known as GPR30, was originally cloned as an orphan receptor and later shown to be specifically activated by 17-ß-estradiol. This has led to its classification as an estrogen receptor and expanded the perspective on the mechanisms underlying the rapid estrogenic effects reported over the years. GPER is strongly expressed in the central nervous system and peripheral tissues and appears to be involved in a wide variety of physiological and pathological processes. Estrogens are known to alter the processing of nocice

APA, Harvard, Vancouver, ISO, and other styles

15

Khawaja, Rabia Raheel. "Role of calcium influx through glutamate receptors in white matter brain injury and oligodendrocyte regeneration." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/583654.

Full text

Abstract:

Biomedical Sciences<br>Ph.D.<br>Calcium-influx through ionotropic glutamate receptors expressed on non-excitable cells, such as CNS glia, may regulate important cell events via intracellular signaling mechanisms. Oligodendrocytes and oligodendrocyte progenitors (OPCs), two glial populations supporting CNS myelination and myelin repair, express AMPA and NMDA receptors. Although calcium-influx through these receptors is thought to cause glutamate excitotoxicity to oligodendrocytes in CNS injuries, more recent studies suggest that AMPA or NMDA receptor-mediated synaptic transmission between neuro

APA, Harvard, Vancouver, ISO, and other styles

16

Schmidt, Ralf [Verfasser], and Frank [Akademischer Betreuer] Würthner. "Hamilton-Receptor-Mediated Self-Assembly of Merocyanine Dyes into Supramolecular Polymers / Ralf Schmidt. Betreuer: Frank Würthner." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1021645737/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

McGlynn, Liane Marie. "The interaction between the type 1 receptor tyrosine kinases and the oestrogen receptor in human breast cancer : the role of the Ras/Raf-1/MAPK pathway." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443199.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Hendrikse, Megan. "Interactions of GPR54 and GPR147 receptors with RF-amide ligands." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/8708.

Full text

Abstract:

Includes bibliographical references.<br>G protein-coupled receptors play a key role in cellular signaling by transducing extracellular signals via G proteins to elicit intracellular responses. Studies have provided evidence supporting the role of the GPCR GPR54 and its cognate peptide ligand, kisspeptin (an RFamide peptide), in the regulation of reproduction. Kisspeptin and GPR54 play a critical role in the control of the hypothalamic-pituitary-gonadal axis by regulating gonadotropin-releasing hormone secretion. Despite the physiological importance of GPR54/kisspeptin signalling, the GRP54 res

APA, Harvard, Vancouver, ISO, and other styles

19

Finley, Matthew James. "Molecular Basis for Kappa-Opioid Regulation of Chemokine Receptor Function." Diss., Temple University Libraries, 2009. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/62878.

Full text

Abstract:

Molecular Biology and Genetics<br>Ph.D.<br>Opioid receptor-mediated regulation of chemokine receptors is vital for the host immune response, development, and neurological function. Previous studies have demonstrated that the kappa opioid receptor (KOR) activation results in decreased infectivity of human immunodeficiency virus 1 (HIV-1) in human peripheral blood mononuclear cells (PBMCs). We have found this effect is due to down-regulation of the major HIV-1 co-receptors, CCR5 and CXCR4. Using molecular techniques, CCR5 and CXCR4 mRNA levels drop dramatically following KOR activation. To disse

APA, Harvard, Vancouver, ISO, and other styles

20

PENG, LI. "Gene Expression Study and DNA Methylation Status of Aryl Hydrocarbon Receptor Gene in Rbf/f;Alb-Cre+ Mouse Liver Tumors." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186635329.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Aramaki, Yo. "Lectin-like oxidized LDL receptor-1 (LOX-1) acts as a receptor for remnant-like lipoprotein particles (RLPs) and mediates RLP-induced migration of vascular smooth muscle cells." Kyoto University, 2008. http://hdl.handle.net/2433/124233.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Gofman, Larisa. "Role of Purinergic Receptor (P2X4) in EtOH-Mediated Microglial Immune Responses." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/315641.

Full text

Abstract:

Pathology<br>Ph.D.<br>Ethanol (EtOH) abuse is the third leading cause of preventable death in the United States. Mounting evidence indicates that EtOH-induced neuropathology may result from multicellular responses in which microglia cells play a prominent role. Purinergic receptor signaling plays a key role in regulating microglial function and, more importantly, mediates EtOH-induced effects. In our current study we sought to determine the effects of EtOH on microglial cell function, specifically the role of purinergic receptor X4 (P2X4) in EtOH-mediated microglial responses. Our results show

APA, Harvard, Vancouver, ISO, and other styles

23

Brito, Filho Francisco de Assis. "VCO Banda Larga Integrado para Receptor a Cinco Portas." Universidade Federal do Rio Grande do Norte, 2009. http://repositorio.ufrn.br:8080/jspui/handle/123456789/15300.

Full text

Abstract:

Made available in DSpace on 2014-12-17T14:55:40Z (GMT). No. of bitstreams: 1 FranciscoAB.pdf: 846082 bytes, checksum: d9718796dd9ac807f8f053e7d371d2bb (MD5) Previous issue date: 2009-09-03<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>This work presents an wideband ring VCO for cognitive radio five-port based receivers. A three-stage differential topology using transmission gate was adopted in order to maintain wide and linear tuning range and a low phase-noise. Monte-Carlo analysis were performed for phase-shift response of individual stages, which is an important figu

APA, Harvard, Vancouver, ISO, and other styles

24

Lemos, Sandra [Verfasser], Michael [Gutachter] Hollmann, and Heumann [Gutachter] Rolf. "Regulation of AMPA receptors by type II-TARPs / Sandra Lemos ; Gutachter: Michael Hollmann, Heumann Rolf." Bochum : Ruhr-Universität Bochum, 2017. http://d-nb.info/1129452433/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Harb, Ali [Verfasser], and Ralf [Akademischer Betreuer] Mohrmann. "AMPA receptor trafficking and regulation by prominent auxiliary subunits in cultured hippocampal neurons / Ali Harb ; Betreuer: Ralf Mohrmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/1197054693/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Mao, Yingying. "ROLE OF PROTEASE-ACTIVATED RECEPTORS IN PLATELET ACTIVATION." Diss., Temple University Libraries, 2009. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/47279.

Full text

Abstract:

Physiology<br>Ph.D.<br>Platelets act as a fundamental component of the hemostatic process and their activation leads to the formation of a stable clot at the injured endothelium surface. Thrombin, as the important physiological agonist, activates platelets through protease-activated receptors (PARs). Protease-activated receptors are one of the major receptors in platelets and belong to the seven-transmembrane G-protein couple receptor family. Four protease-activated receptors are found, named as PAR1, PAR2, PAR3 and PAR4. Human platelets express PAR1 and PAR4 and murine platelets express

APA, Harvard, Vancouver, ISO, and other styles

27

Limaye, Arati. "RECEPTOR MEDIATED ORAL DELIVERY OF BIOENCAPSULATED GREEN FLUORESCENT PROTEIN EXPRESSED IN TRANSGENIC CHLOROPLASTS." Master's thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4295.

Full text

Abstract:

The skyrocketing costs of prescription medicine in developed countries and their lack of availability in developing countries are the most challenging problems of human health. Primary reasons for such high cost are fermentation-based production, expensive purification methods, the need for low temperature storage and transportation and the delivery through sterile injections. Most of these expenses could be minimized or eliminated when therapeutic proteins are expressed and orally delivered via plant cells. Chloroplasts have the machinery to fold complex and biologically active eukaryotic pro

APA, Harvard, Vancouver, ISO, and other styles

28

Robinson, Rebecca Hartzell. "Cannabinoid Receptor 2-Selective Ligands as Immunosuppressive Compounds: Utility in Graft Rejection." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/246094.

Full text

Abstract:

Microbiology and Immunology<br>Ph.D.<br>Cannabinoids are known to have anti-inflammatory and immunomodulatory properties. Cannabinoid receptor 2 (CB2) is expressed mainly on leukocytes and is the receptor implicated in mediating many of the effects of cannabinoids on immune processes. The capacity of delta-9-tetrahydrocannabinol (delta-9-THC) and of two CB2-selective agonists to inhibit the murine Mixed Lymphocyte Reaction (MLR), an in vitro correlate of graft rejection following skin and organ transplantation was tested. Both CB2-selective agonists and delta-9-THC significantly suppressed the

APA, Harvard, Vancouver, ISO, and other styles

29

Regan, Patrick M. "Regulation and Functional Impact of Opioid Receptor Splicing in Response to Morphine." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/344730.

Full text

Abstract:

Biomedical Neuroscience<br>Ph.D.<br>Multiple classes of pharmaceuticals, including acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs), are used to relieve mild to moderate pain; however, one of the oldest classes of pharmaceuticals, opioids, remains the primary class of drugs used in the management of severe pain. For decades, the unique pharmacological profiles of opioid compounds have suggested the existence of multiple opioid receptor subtypes and, accordingly, four opioid receptors have been cloned to date; the mu (μ)-opioid receptor, the kappa (κ)-opioid recep

APA, Harvard, Vancouver, ISO, and other styles

30

Bettembourg, Mathilde. "Caractérisation de récepteurs à activité kinase impliqués dans la mise en place de l'architecture racinaire chez le riz." Thesis, Montpellier, SupAgro, 2016. http://www.theses.fr/2016NSAM0026.

Full text

Abstract:

Les racines ont deux grands rôles. Le premier est le prélèvement de l’eau et des éléments nutritifs et le second est l’ancrage dans le sol. Identifier les gènes responsables de la mise en place des tissus et de l'architecture du système racinaire est donc essentiel pour pouvoir améliorer les variétés de riz soumises à des stress abiotiques de plus en plus fréquents et nombreux du fait du changement climatique. Au cours de cette thèse, j'ai réalisé une analyse fonctionnelle du gène DEFECTIVE IN OUTER CELL LAYER SPECIFICATION (DOCS1) qui appartient à la famille des récepteurs kinases à répétitio

APA, Harvard, Vancouver, ISO, and other styles

31

Salvadeo, Danielle Marie. "TO PEE OR NOT TO PEE: A CHARACTERIZATION OF CANINE BLADDER PHYSIOLOGY FOLLOWING LONG-TERM LOWER SPINAL ROOT TRANSECTION AND SURGICAL REINNERVATION." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/561128.

Full text

Abstract:

Biomedical Sciences<br>Ph.D.<br>Bladder incontinence in patients who suffer from sacral spinal cord injury can wreak havoc on one's quality of life. A 2012 survey suggests that patients who sustain spinal cord injury prioritize the recovery of bladder function over other faculties. With about 12,000 new spinal cord injury cases reported in the United States each year, finding ways to combat the disabilities that result from lower spinal cord dysfunction should be of utmost importance to the scientific research community. Prior to studying the effects of surgical reinnervation on the bladder af

APA, Harvard, Vancouver, ISO, and other styles

32

Fan, Yanfeng. "THE APPLICATION OF SPIROLIGOMERS TOWARDS MOLECULAR RECOGNITION AND ORGANOCATALYSIS." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/576554.

Full text

Abstract:

Chemistry<br>Ph.D.<br>This thesis presents the development of bis-amino acid-based spiroligomer applications in the areas of molecular recognition and organocatalysis. By taking advantage of the high degree of functionality and chirality of the unique bis-amino acid building blocks, spiroligomer backbones can be synthesized with predefined shapes, functioning as molecular hosts or as enzyme active-site-like pockets. Firstly, we demonstrated that spiroligomers can be designed to act as anion receptors. We designed a collection of spiroligomers that each display two urea groups. The spiroligomer

APA, Harvard, Vancouver, ISO, and other styles

33

Venkataraman, Rajarajeshwari. "ROLE OF TRANSIENT RECEPTOR POTENTIAL CANONICAL-6 (TRPC6) CHANNEL IN METASTASIS OF GLIOBLASTOMA MULTIFORME." Master's thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4353.

Full text

Abstract:

Glioblastoma multiforme (GBM) is one of the extremely fatal brain tumors. The main reason that makes it so lethal is its capability to invade and spread to other parts of CNS producing secondary tumors. Among other factors hypoxia, reduced oxygen availability, is linked to higher metastatic potential of cancers. Hypoxia causes numerous changes in genome and proteome of the cell. These changes help a normal cell to adapt to nutritional deficiency, but the same changes can increase the malignancy and metastasis in tumor cells. Extensive research by a number of curious scientists reveal that vari

APA, Harvard, Vancouver, ISO, and other styles

34

Chang, Jen-Kuan. "The Biochemical Basis of The miR-21 Expression by The Mu-Opioid Receptor." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/352105.

Full text

Abstract:

Molecular Biology and Genetics<br>Ph.D.<br>Opioid receptors are members of the superfamily of seven transmembrane G protein-coupled receptors (GPCRs) which share several structural and functional characteristics. There are 3 subtypes of opioid receptors, designated μ (MOR), δ (DOR), and κ (KOR) opioid receptors, have been found in the immune, nervous, gastrointestinal and other tissues. We have attempted to clarify the nature of MOR-induced signal transduction pathways in leukocytes. We found that the activation of MOR leads to a significant induction of ERK phosphorylation in peripheral blood

APA, Harvard, Vancouver, ISO, and other styles

35

Happel, Christine. "Molecular Basis for Mu-Opioid Regulation of Chemokine Gene Expression." Diss., Temple University Libraries, 2009. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/28438.

Full text

Abstract:

Molecular Biology and Genetics<br>Ph.D.<br>Opioid receptor modulation of pro-inflammatory cytokine production is vital for host defense and the inflammatory response. Previous results have shown the mu-opioid receptor (MOR) selective agonist, DAMGO, has the capacity to increase the expression of the pro-inflammatory chemokines, CCL2/MCP-1, CCL5/RANTES and CXCL10/IP-10 in peripheral blood mononuclear cells (PBMCs). We have shown that MOR activation is able to induce the expression of TGF-β, and TGF-β appears to be required for induction of CCL5 following MOR activation. This work suggests a nov

APA, Harvard, Vancouver, ISO, and other styles

36

Lorch, Robert A. "MicroRNA regulation of prostate cancer desensitization to androgen receptor antagonist drugs during androgen deprivation therapy." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/462.

Full text

Abstract:

The current standard treatment of prostate cancer by androgen deprivation therapy involves using drugs such as bicalutamide (Casodex) to antagonistically block androgen receptors that are normally present within prostate cells. Usually, the therapy is successful in the short run at limiting the growth of prostate cancer. However, in virtually all cases tumors begin to grow aggressively again after several months of treatment and new therapies must be started. The mechanism by which these prostate cells transform from androgen sensitive to androgen independent and anti-androgen resistant is unc

APA, Harvard, Vancouver, ISO, and other styles

37

Bright, Nieka L. "Glutamate Receptor, Ionotropic N-methyl-D-aspartate 2B Polymorphisms and Concussive Recovery in Athletes." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216565.

Full text

Abstract:

Kinesiology<br>Ph.D.<br>Athletes vary in their ability to recover from concussions. Following a concussion, a pathophysiological cascade of events transpires, rendering symptoms. One such event, the indiscriminate release of the excitatory neurotransmitter glutamate, may result in hyperactivation of glutamate receptors (e.g., N-methyl-D-aspartate receptors [NMDARs]) and self-propagate a state of neurotoxicity that may be enhanced via the concomitant release of Ca2+, particularly through NMDARs containing the NR2B subunit. Genetic variation in regulatory regions of the glutamate receptor, ionot

APA, Harvard, Vancouver, ISO, and other styles

38

Guo, Shuchi. "EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) – AN ESSENTIAL MEDIATOR OF CARDIAC CONTRACTILE FUNCTION AND REMODELING." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/555214.

Full text

Abstract:

Biomedical Sciences<br>Ph.D.<br>Epidermal Growth Factor Receptor (EGFR), a member of the Erbb receptor tyrosine kinase family, is essential to the development of multiple tissue and organs. Due to the embryonic lethality of global EGFR deletion, the impact of EGFR signaling in the adult heart, normally or in response to pathological stimuli, has not been well-explored. Using recently attained mice with floxed EGFR alleles crossed with αMHC-Cre mice, we have generated a cardiomyocyte-specific constitutive EGFR knockout mouse model (CM-EGFR KO) to address its role in the heart. Compared to their

APA, Harvard, Vancouver, ISO, and other styles

39

Lougnon, Géraldine. "Analyse fonctionnelle des gènes précoces impliqués dans la symbiose fixatrice d'azote entre Medicago truncatula et Sinorhizobium meliloti." Paris 11, 2007. http://www.theses.fr/2007PA112103.

Full text

Abstract:

Les légumineuses utilisent une voie de signalisation commune pour établir l’association symbiotique avec les rhizobiums et les champignons endomycorhiziens. La perception du microorganisme a lieu à la membrane plasmique et active une cascade de transduction du signal jusqu’au noyau pour la transcription de gènes spécifiques. Le gène NORK chez les espèces de Medicago code pour un récepteur kinase-like, composant de la voie de signalisation des facteurs Nod et essentiel pour le développement de la nodosité. Pour comprendre le rôle de NORK, nous avons cherché des protéines partenaires agissant en

APA, Harvard, Vancouver, ISO, and other styles

40

Albano, Jennifer Nicole. "Localization of Human Prostaglandin E2 Receptors in Polarized Epithelial Cells." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/17898.

Full text

Abstract:

Pharmacology<br>Ph.D.<br>The underlying mechanisms of protein sorting in polarized epithelial cells are poorly understood. Several studies have determined membrane targeting of G protein-coupled receptors (GPCRs) using epithelial cells such as Madin-Darby canine kidney (MDCK) cells. Polarized epithelial cells are composed of apical and basolateral plasma membrane domains with specific protein compositions separated by tight junctions. Purinergic, muscarinic, and adrenergic receptors are a few examples of GPCRs that have been shown to localize to specific membranes in MDCK cells. The current wo

APA, Harvard, Vancouver, ISO, and other styles

41

Nattkemper, Leigh. "MEDIATORS AND RECEPTORS OF CHRONIC ITCH IN PRIMATES AND HUMANS." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/360207.

Full text

Abstract:

Biomedical Sciences<br>Ph.D.<br>Chronic itch has a significant impact on quality of life for millions of patients worldwide, on a level comparable to that of chronic pain. Yet, although there are a host of effective drugs available for pain, there are no therapies that specifically target chronic itch. Current experimental approaches to investigate the pathogenesis of chronic pruritus and to test novel therapeutic agents are largely limited to rodent models. However, rodent models display significant dermatological, neurophysiological, and immunological differences from humans with chronic itc

APA, Harvard, Vancouver, ISO, and other styles

42

Nguyen, The Duy [Verfasser], Rolf [Gutachter] Marschalek, and Christian [Gutachter] Brandts. "The role of the selective autophagy receptor p62 in acute myeloid leukemia / The Duy Nguyen ; Gutachter: Rolf Marschalek, Christian Brandts." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2018. http://d-nb.info/1157097979/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Reichenbach, Zachary Wilmer. "Modulation of the Endogenous Cannabinoid System to Attenuate Inflammation in Central Nervous System Injury." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/253514.

Full text

Abstract:

Physiology<br>Ph.D.<br>In non-pathological states the central nervous system maintains a degree of immunological privilege. When illness or injury occur, this privilege can be lost and the immune system drives pathology in the brain and spinal cord. More so, resident immune cells, the microglial, act as major effectors of this response. Cerebral ischemia, or stroke, is the fourth leading cause of death in developed nations. After the initial ischemia, the inflammatory response propagates further injury and cell death. Another affliction of the central nervous system, chronic pain and persisten

APA, Harvard, Vancouver, ISO, and other styles

44

Oppong, Gertrude Odamea. "The Role of Bacterial Amyloids In Regulating Gastrointestinal Homeostasis." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/323094.

Full text

Abstract:

Microbiology and Immunology<br>Ph.D.<br>Many bacterial species exist in nature as part of highly structured multicellular communities known as biofilms. Amyloids, proteins with a conserved β-sheet quarternary structure, show high resistance to many chemical and enzymatic processes including proteinase K and SDS treatments and are produced as essential adhesins during biofilm formation. Curli fibers expressed by Enterobacteriaceae family members including E. coli and S. Typhimurium are the most studied amyloids to date. Curli-like fibers are also produced by members of the predominant phyla fou

APA, Harvard, Vancouver, ISO, and other styles

45

Dunn, Stanley Ingrid P. "The neurofibromatosis type 2 gene product, merlin, binds, directly to the epidermal growth factor receptor, ErbB2." Honors in the Major Thesis, University of Central Florida, 2000. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/188.

Full text

Abstract:

This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Health and Public Affairs<br>Molecular and Microbiology

APA, Harvard, Vancouver, ISO, and other styles

46

Liang, Chengya. "Extracullular ATP Regulates IL-1Beta Release from Microglial Cells Via Purinergic Receptor After In Vitro Trauma." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4420.

Full text

Abstract:

Traumatic brain injury (TBI) induces a state of microglialactivation, which includes upregulation of macrophage functions and release inflammatory mediators such as certain inflammatory cytokines. Current literature suggests that interleukin-1Beta is an important cytokine mediator, which is dramatically increased after brain injury. Previous studies indicate that ATP is released by traumatically injured astrocytes and serves as a cell-to-cell mediator through purinergic receptors after in vitro injury. However, the mechanism of interleukin-1Beta release after traumatic brain injury remains poo

APA, Harvard, Vancouver, ISO, and other styles

47

Bhandare, Richie R. "Investigation into the bioisosteric approach in the design, synthesis and evaluation of muscarinic receptor ligands." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/214985.

Full text

Abstract:

Pharmaceutical Sciences<br>Ph.D.<br>The acetylcholine (ACh) receptor system belongs to rhodopsin GPCR family and is an integral membrane protein divided into two types: muscarinic and nicotinic. The naturally occurring neurotransmitter acetylcholine binds to these two receptor systems non- selectively. The regulatory effects of the neurotransmitter acetylcholine are diverse ranging from autonomic nervous system and the central nervous system through different types of neurons innervated by cholinergic inputs. Muscarinic acetylcholine receptors (mAChRs) are divided into five receptor subtypes (

APA, Harvard, Vancouver, ISO, and other styles

48

Nwaneshiudu, Chinwe A. "Characterization of a functional role of the neurokinin-3 receptor in behavioral effects of cocaine." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/62614.

Full text

Abstract:

Pharmacology<br>Ph.D.<br>The tachykinin NK-3 receptor is a G-protein coupled receptor activated by mammalian tachykinin neuropeptides, which can modulate dopaminergic neurotransmission, and alter dopamine-mediated behaviors. The NK-3 receptor is currently under investigation as a novel therapeutic target for cocaine addiction. Our studies, as outlined in this dissertation, sought to determine if NK-3 receptors have a functional role in the acute as well as long-term behavioral effects of cocaine. Administration of NK-3 receptor agonists or antagonists potentiates or attenuates dopamine-med

APA, Harvard, Vancouver, ISO, and other styles

49

König, Christopher Verfasser], Sylvia [Gutachter] Anton, Rolf G. [Gutachter] [Beutel, and Bill S. [Gutachter] Hansson. "Chemosensory receptors in the tobacco hawkmoth Manduca sexta / Christopher König ; Gutachter: Sylvia Anton, Rolf Beutel, Bill S. Hansson." Jena : Friedrich-Schiller-Universität Jena, 2016. http://d-nb.info/1177612232/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

König, Christopher [Verfasser], Sylvia Gutachter] Anton, Rolf G. [Gutachter] [Beutel, and Bill S. [Gutachter] Hansson. "Chemosensory receptors in the tobacco hawkmoth Manduca sexta / Christopher König ; Gutachter: Sylvia Anton, Rolf Beutel, Bill S. Hansson." Jena : Friedrich-Schiller-Universität Jena, 2016. http://d-nb.info/1177612232/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!