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Dissertations / Theses on the topic 'RNA dependent DNA methylation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

He, Jie. "Isolation of An ARGONAUTE Gene in Pelargonium and Identification Of Candidate Genes Regulated Through ARGONAUTE4-Dependent RNA-Dependent DNA Methylation In Arabidopsis." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1260812913.

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Dissertation (Ph.D.)--University of Toledo, 2009.<br>Typescript. "Submitted as partial fulfillment of the requirements for the Doctor of Philosophy degree in Biology." Bibliography: leaves 54-56, 91-95, 118-119, 133-139.

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2

Ostler, Jeffery Brent Jr. "Characterization of Pol IV and Pol V-Dependent Non-Coding RNAs Derived from aGeminivirus Genome." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492698361649423.

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3

Taylor, Laura Margaret. "Aspects of RNA directed DNA methylation in Arabidopsis thaliana." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648263.

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4

Joardar, Archi. "GUIDE RNA-DEPENDENT AND INDEPENDENT tRNA MODIFICATIONS IN ARCHAEA." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/dissertations/625.

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Stable RNAs undergo a wide variety of post-transcriptional modifications, that add to the functional repertoire of these molecules. Some of these modifications are catalyzed by stand-alone protein enzymes, while some others are catalyzed by RNA-protein complexes. tRNAs from all domains of life contain many such modifications, that increase their structural stability and refine their decoding properties. Certain regions of tRNAs are more frequently modified than others. Two such regions are the anticodon loop, and the TψC stem. In the halophilic euryarchaeon Haloferax volcanii, tRNATrp and tRNA

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5

Flower, Kirsty. "Methylation dependent interactions of viral transcription factor Zta with DNA." Thesis, University of Sussex, 2011. http://sro.sussex.ac.uk/id/eprint/39322/.

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Epstein Barr Virus, a human herpes virus associated with infectious mononucleosis, Burkitt's lymphoma, Nasopharyngeal Carcinoma and Hodgkin's disease, can infect B cells and establish latency. Zta, a member of the bZIP transcription factor family, is a viral transcription and replication factor required for activation of lytic cycle. Zta is able to bind DNA, through specific Zta Response Elements (ZREs). Interestingly, Zta binds in a methylation dependent manner to specific CpGcontaining ZREs, known as Class III ZREs. RpZRE3 is one of the first examples of such a site, and can be found in the

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6

O'Hanlon, Karen Ann. "Studies on the enzyme DNA-dependent RNA polymerase." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266340.

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7

Varshney, Dhaval. "Regulation of RNA polymerase III transcription by DNA methylation and chromatin." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3114/.

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Mammalian genomes contain huge numbers of short interspersed elements (SINEs). An extreme case is provided by the human genome, which carries ~106 copies of Alu SINEs that together account for ~10% of total chromosomal DNA. SINEs spread by retrotransposition, which depends on their transcription by pol III. This transcription is heavily suppressed. Silencing is thought to involve DNA methylation and packaging the SINEs into chromatin structures that deny access of transcription factors. It has been argued that this may be of great importance to prevent SINEs from competing with essential genes

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8

Mondal, Tanmoy. "Epigenetic Regulation by Noncoding RNA." Doctoral thesis, Uppsala universitet, Genomik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160326.

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High throughput transcriptomic analyses have realized us with the fact that eukaryotic genome encodes thousands of noncoding RNAs (ncRNAs) with unknown function. In my thesis, I sought to address epigenetic regulation of transcription by ncRNA using the Kcnq1 imprinted cluster as a model system. Genomic imprinting is an epigenetic phenomenon whereby one of the parental alleles is silenced by epigenetic mechanism in a parent of origin-specific manner. A long ncRNA Kcnq1ot1 regulates imprinting of nearly 8 protein coding genes in the Kcnq1 imprinted cluster. Expression of Kcnq1ot1 is restricted

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9

Yim, Lok-hay Rita, and 嚴樂晞. "DNA methylation of tumour suppressive microRNA in mantle cell lymphoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/210192.

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10

Choudury, Sarah G. Choudury. "Identification and characterization of proteins required for RNA-directed DNA Methylation, including the RNA binding protein ALY1." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543508792612526.

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11

Bhoi, Sujata. "Prognostic markers and DNA methylation profiling in lymphoid malignancies." Doctoral thesis, Uppsala universitet, Experimentell och klinisk onkologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328616.

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In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), at the genomic, transcriptomic and epigenomic level for accurate risk-stratification and prediction of treatment response. In paper I, we validated the prognostic relevance of a recently proposed RNA-based marker in CLL, UGT2B17, and analyzed its expression levels in 253 early-stage patients. Besides confirming its prognostic impact in multivariate analysis, we could identify 30% of IGHV-mutated CLL (M-CLL)

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12

Mutize, Tinashe. "DNA methylation : a risk factor for type 2 diabetes mellitus." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2388.

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Thesis (MSc (Biomedical Technology))--Cape Peninsula University of Technology, 2016.<br>The early detection of individuals who are at risk of developing type 2 diabetes mellitus (T2DM) would decrease the morbidity and mortality associated with this disease. DNA methylation, the most widely studied epigenetic mechanism, offers unique opportunities in this regard. Aberrant DNA methylation is associated with disease pathogenesis and is observed during the asymptomatic stage of disease. DNA methylation has therefore attracted increasing attention as a potential biomarker for identifying individual

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13

Wong, Kwan-yeung, and 黃君揚. "Promoter DNA methylation of tumour suppressor microRNA genes in multiple myeloma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47331513.

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Multiple myeloma (MM) is an incurable haematological malignancy. It is characterized clinically by an asymptomatic precursor stage, known as monoclonal gammopathy of undetermined significance (MGUS), which will transform into symptomatic MM at a rate of 1% per year. Gene promoter hypermethylation by catalytic conversion of cytosine into 5?methylcytosine at promoter?associated CpG island is an alternative mechanism of gene inactivation. MicroRNA (miRNA) is a class of short, single?stranded, non?coding RNA molecules, which will repress the expression of target protein by sequence?specifi

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14

Aregger, Michael. "Cell cycle-dependent regulation of the human RNA cap methyltransferase (RNMT)." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/3bf175e1-145e-4cbf-85d8-09affb50ac90.

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The N-7 methylguanosine cap structure is conserved from yeast to man. It is essential for cell proliferation as it influences several steps in eukaryotic gene expression including transcription, pre-mRNA processing, RNA export and translation. The N-7 methylguanosine cap is added co-transcriptionally to RNA pol II transcripts. In mammals, two enzymes catalyse the synthesis of the N7-methylguanosince cap. RNGTT adds an inverted guanosine group to the first transcribed nucleotide and RNMT methylates the guanosine cap at the N7-position. RNMT consists of a catalytic domain and an N-terminal domai

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15

Jia, Yiping. "Mechanistic studies of DNA-dependent transcription initiation and RNA synthesis by bacteriophage T7 RNA polymerase /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487953204281995.

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16

Firth, Andrew Graeme. "Synthesis and Characterisation of Fluorescent RibonucleotideSubstrates for DNA Dependent RNA Polymerases." Thesis, University of York, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507614.

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17

Dofková, Květoslava. "Analýza genů pro ribozomální RNA u variet Brassica napus (řepka olejka)." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2011. http://www.nusl.cz/ntk/nusl-216749.

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Brassica napus (AACC, 2n = 38) is an allotetraploid species derived from the parentel diploid species Brassica rapa (AA, 2n = 20) and Brassica oleracea (CC, 2n = 18). The aim of thesis was to carry out the genetic and epigenetic analysis of high-copy rRNA genes (or rDNA) in several varieties of hybrid species B. napus. The experiments involved determining the ratio of parental genes in hybrids, sequencing and methylation analysis of the promoter region of rDNA. Using Southern hybridization, it was revealed significant variability in the number of parental rDNA units between each variety. Data

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18

Huang, Linfeng. "A biochemical study of DNA-dependent RNA polymerase IV complex in plants." Thesis, University of East Anglia, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492962.

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19

Jackel, Jamie Nicole. "GEMINIVIRUSES AS MODELS TO STUDY THE ESTABLISHMENT AND MAINTENANCE OF DNA METHYLATION." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1367494030.

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20

KISHORE, KAMAL. "DEVELOPMENT OF COMPUTATIONAL TOOLS TO STUDY THE PATTERNING OF DNA AND RNA METHYLATION IN HEALTHY AND DISEASE STATES." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/358286.

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Epigenetics can be defined as the set of sequence independent processes that produces heritable changes in cellular information. These chromatin-based events such as covalent modification of DNA and histone tails are laid down by the co-ordinated action of chromatin modifying enzymes, thus altering the organisation of chromatin and its accessibility to the transcriptional machinery. Our understanding of epigenetic intricacies has considerably increased over the last decade owing to rapid development of genomic and proteomic technologies. This has resulted in huge surge in the generation

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21

Wiehle, Laura [Verfasser], and Frank [Akademischer Betreuer] Lyko. "TET-dependent DNA methylation patterns in mammalian development and disease / Laura Wiehle ; Betreuer: Frank Lyko." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1178010325/34.

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22

Johansson, Jennie. "Epigenetic Regulation of Mitochondrial DNA." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166684.

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This mini-review investigates and compiles the latest knowledge regarding epigenetic changes on the mammalian mitochondrial DNA and its proteins. Methylation of the DNA, acetylation of the proteins and silencing of genes by short non-coding RNAs are the main epigenetic changes known today to affect mitochondrial DNA, mostly leading to repression. Methylation mainly occurs at non-CpG sites in the main non-coding region called the D-loop, with methylation patterns being cell type specific. Acetylation of proteins are mainly controlled by the deacetylase SIRT3, with its function being correlated

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23

Boyer, Angelique Sun. "Purification and characterization of a chloroplast DNA-dependent soluble RNA polymerase from pea." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186651.

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A chloroplast DNA-dependent RNA polymerase has been purified 350,000-fold from pea. The purification procedure includes the following steps: 100,000 x g centrifugation, DE-52 ion exchange chromatography, ammonium sulfate precipitation, Sephacryl S-300 gel filtration and two sequential Mono-Q columns. The purified protein preparation was resolved into a predominant protein complex at 669 kDa by non-denaturing gel electrophoresis. Based on gel filtration chromatography the native molecular weight of the purified enzyme is approximately 620,000. Using SDS-PAGE the purified enzyme is separated int

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24

Larkin, Robert M. "Analysis of nuclear DNA-dependent RNA polymerase subunits and tata-binding protein from plants /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9821341.

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25

Vasale, Jessica J. "Roles of Cellular RNA-Dependent RNA Polymerases in Endogenous Small RNA Pathways in Caenorhabditis elegans: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/481.

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The RNA interference (RNAi) pathway in Caenorhabditis elegans is a two-step, small RNA-mediated silencing pathway. Unlike in other organisms, Dicer processing of double-stranded RNA into small interfering (si) RNAs is not sufficient in worms to induce gene silencing. The activity of cellular RNA-dependent RNA polymerase (RdRP) is necessary to synthesize a secondary pool of siRNAs, which interact with a unique class of Argonaute proteins to form the functional effector complexes that mediate silencing. The aims of this thesis were to: 1) characterize the role of RdRP family members in endogenou

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26

Mohammad, Faizaan. "Long Noncoding RNA Mediated Regulation of Imprinted Genes." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128882.

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Genomic imprinting is an epigenetic phenomenon that causes a subset of mammalian genes to be expressed from only one allele in a parent-of-origin manner. The defects in the imprinting regulation result in disorders that affect development, growth and metabolism. We have used the Kcnq1 imprinted cluster as a model to understand the mechanism of imprinted gene regulation. The imprinting at the Kcnq1 locus is regulated by a long noncoding RNA, Kcnq1ot1, whose transcription on the paternal chromosome is associated with the silencing of at least eight neighboring genes. By destabilizing Kcnq1ot1 in

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27

Panda, Kaushik Kant. "Genome-Wide Regulation of Both Canonical and Non-canonical RNA-directed DNA Methylation Mechanisms in Arabidopsis thaliana." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1512116266715136.

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28

Brabbs, Thomas. "Identification and characterisation of MORC6 as a component of the RNA-directed DNA methylation pathway in Arabidopsis thaliana." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/3673/.

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RNA silencing pathways control the expression of genes and other DNA loci by the action of small RNA molecules and are found in many eukaryotes. In plants there are a number of RNA silencing pathways, of which RNA-directed DNA methylation (RdDM) is one. In this pathway the small RNA molecules direct DNA methylation, resulting in the down regulation of expression of the target locus. In terms of the mechanism of the pathway it is mostly well characterised but several gaps exist in our knowledge. These relate to its initiation, where it is not known how RdDM targets the correct locus; methylatio

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Moreland, Blythe S. "Genome-wide studies of DNA and RNA with modifications through high-throughput sequencing analysis." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu153452875946939.

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30

Hög, Friederike. "Functional studies of RNA polymerase II recruitment to promoter DNA and impact of BRF1 mutations on RNA polymerase III-dependent transcription." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-179326.

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31

Wong, David J. S. "Methylation of the p16 CpG island during neoplastic progression /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5074.

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32

Rambani, Aditi. "Transcriptome and Methylation Analysis of Gossypium Petal Tissue." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3910.

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Polyploidization instantly doubles all genome content by combining two genomes that have markedly different methylation and gene expression levels. This process may be accompanied by genetic and epigenetic changes in each genome. Sequencing of the transcriptome (RNA-seq) and the methylome (bisulfite treated libraries whole genome libraries) were used to measure gene expression and methylation levels of genic regions of allopolyploid cotton petals and petals of their diploid relatives. Many differentially expressed genes detected by RNA-seq were consistent with expression levels previously dete

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Lowings, Michael D., and University of Lethbridge Faculty of Arts and Science. "Epigenetic regulation of stroke recovery : changes in DNA methylation and micro-RNA regulation following stroke and EGF/EPO neurogenesis therapy." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010, 2010. http://hdl.handle.net/10133/2570.

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Stroke is one of the most common, and damaging, neurological afflictions. Stroke causes widespread and variable chronic effects, due to the limited regenerative ability of the adult brain. Altered gene expression induces neuronal changes necessary for plasticity-dependent recovery, effects which can be enhanced by growth hormone-based pharmaceuticals. These processes are driven by alterations in the informational capacity of the genome – changes driven by epigenetic regulators. Following experimental strokes, and treatment with EGF and EPO, this study shows that two epigenetic regulator

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Wise, Ingrid. "Epigenetic modifications in essential hypertension." Thesis, Federation University of Australia, 2018. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/165633.

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Background: Hypertension (HTN) is a complex, multifactorial, quantitative trait under polygenic control that affects more than one billion people globally. Despite advances in our understanding of the pathophysiology of HTN and the implementation of more effective treatment and prevention strategies, HTN remains one of the world’s great public health problems. The accepted inference from genome-wide association studies (GWAS) is that the genetic code lays the foundation for transcriptomic changes and in turn physiological change. On the other side of the coin, environmental factors (smoking, d

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35

Buchmann, Cody. "Reversal of RNA-mediated gene silencing pathways by geminivirus AL2 and L2 proteins." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1221847080.

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36

Schönberger, Brigitte [Verfasser], and Uwe [Akademischer Betreuer] Ludewig. "Site-dependent differences in DNA methylation and their impact on plant establishment in Populus trichocarpa / Brigitte Schönberger ; Betreuer: Uwe Ludewig." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2016. http://d-nb.info/1122168608/34.

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37

Heckmann, Irina [Verfasser], and Stefan [Akademischer Betreuer] Jentsch. "DNA damage-induced degradation of elongating RNA polymerase II by a SUMO-dependent mechanism / Irina Heckmann ; Betreuer: Stefan Jentsch." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1173087567/34.

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Hög, Friederike [Verfasser], and Patrick [Akademischer Betreuer] Cramer. "Functional studies of RNA polymerase II recruitment to promoter DNA and impact of BRF1 mutations on RNA polymerase III-dependent transcription / Friederike Hög. Betreuer: Patrick Cramer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1067055290/34.

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Islam, Helena. "Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene." Kyoto University, 2020. http://hdl.handle.net/2433/254517.

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付記する学位プログラム名: 充実した健康長寿社会を築く総合医療開発リーダー育成プログラム<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医科学)<br>甲第22697号<br>医科博第112号<br>新制||医科||8(附属図書館)<br>京都大学大学院医学研究科医科学専攻<br>(主査)教授竹内理, 教授髙折晃史, 教授河本宏<br>学位規則第4条第1項該当

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Laukka, T. (Tuomas). "The role of 2-oxoglutarate-dependent dioxygenases in epigenetic regulation of cancer." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526220598.

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Abstract 2-oxoglutarate-dependent dioxygenases (2-OGDDs) are an enzyme family that contains many enzymes that modify chromatin in extensive ways. These enzymes include several histone lysine demethylases (KDMs) and TET enzymes that convert methylated cytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) ultimately leading to DNA demethylation. Disturbed DNA and histone methylation are found in many cancers. However, the role of KDMs and TETs behind these oncogenic changes has so far not been fully investigated. This study focused on the role of these chromatin-modifying enzymes in cancers with sp

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Phalke, Sameer [Verfasser], Gunther Akademischer Betreuer] Reuter, Jörn [Akademischer Betreuer] [Walter, and Anne [Akademischer Betreuer] Ehrenhoffer-Muerey. "Alternative DNA methylation dependent gene silencing pathways and its affect on genome stability in Drosophila / Sameer Phalke. Betreuer: Gunther Reuter ; Jörn Walter ; Anne Ehrenhoffer-Muerey." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2009. http://d-nb.info/1024874672/34.

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Hu, Guojian. "Hormonal and epigenetic control of pollination-dependent and pollination-independent fruit-setting in tomato." Phd thesis, Toulouse, INPT, 2017. http://oatao.univ-toulouse.fr/18575/1/HU.pdf.

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The flower-to-fruit transition, so-called fruit setting, is triggered by flower pollination and this process is essential for plant reproductive success, seed formation and crop yield. The underlying molecular mechanisms controlling this developmental transition remain unclear. Histone marking and DNA methylation are the main epigenetic modes for genetic reprogramming, however, their respective contribution to the fruit set-associated transcriptomic reprogramming is also unknown. To address the contribution of the two types of epigenetic regulation to fruit set, genome-wide transcriptomic prof

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Yang, Diya. "Genome-wide Analysis of F1 Hybrids to Determine the Initiation of Epigenetic Silencing in Maize." Miami University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1610098527086245.

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Easwaran, Hariharan P. "A complex interplay of regulatory domains controls cell cycle dependent subnuclear localization of DNMT1 and is required for the maintenance of epigenetic information." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2004. http://dx.doi.org/10.18452/15069.

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DNA-Methylierung spielt eine wichtige Rolle bei der Kontrolle der Chromatinorganisation und Genregulation in höheren Eukaryoten und muss zusammen mit der genetischen Information in jedem Zellzyklus dupliziert werden. Bei Mammalia wird DNA durch die DNA-Methyltransferase 1 (DNMT1) methyliert, die dabei mit nuklearen Replikationsstellen (RF) assoziiert und so die Erhaltung des Methylierungsmusters mit der Duplikation der DNA verbindet. In dieser Arbeit wurden die Funktion der regulatorischen Sequenzen in der N-terminalen Domäne von DNMT1 bei der Kontrolle ihrer subnuklearen Lokalisierung während

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Trujillo, Joshua T., Mark A. Beilstein, and Rebecca A. Mosher. "The Argonaute-binding platform of NRPE1 evolves through modulation of intrinsically disordered repeats." WILEY-BLACKWELL, 2016. http://hdl.handle.net/10150/622374.

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• Argonaute proteins are important effectors in RNA silencing pathways, but they must interact with other machinery to trigger silencing. Ago hooks have emerged as a conserved motif responsible for interaction with Argonaute proteins, but little is know about the sequence surrounding Ago hooks that must restrict or enable interaction with specific Argonautes. • Here we investigated the evolutionary dynamics of an Argonaute-binding platform in NRPE1, the largest subunit of RNA Polymerase V. We compared NRPE1 sequences from more than 50 species, including dense sampling of two plant lineages.

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Chalei, Vladislava. "Investigating molecular mechanisms of Dali, an intergenic chromatin-associated lincRNA regulating genes locally and neural differentiation genome-wide." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:9c296666-927c-4c53-b250-39e79643b0f8.

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Recently, long non-coding RNAs (lncRNAs) emerged as important regulators of many cellular functions. Many nuclear lncRNAs regulate the expression of geomically proximal or overlapping protein coding genes. Less clear is whether intergenic lncRNAs can regulate transcription by modulating chromatin at genomically distant loci in an RNA-dependent manner. This thesis investigated molecular functions of Dali, an intergenic central nervous system expressed lncRNA conserved in therian mammals. Dali is transcribed from a locus 50 kb downstream of the Pou3f3 transcription factor gene and performs both

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Rosselló, Tortella Margalida. "Epigenetic Regulation of tRNA Biology in Cancer." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673026.

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Transfer RNAs (tRNAs) are essential molecules that allow the translation of the genetic code into amino acids. Extensive research during the last 50 years have revealed that, despite their apparently simple structure and function, tRNAs are more than simple adaptors in protein synthesis –they are of high importance in normal cell functions. Reinforcing this, tRNA levels are tightly regulated to match the codon usage patterns of a given cell type or cellular status to meet the cellular specific needs and adapt to stress. Moreover, tRNA nucleoside modifications are critical for their function at

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Philips, Joshua George. "Epigenetic fate of T-DNAs during the early stages of Agrobacterium infection." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/127056/1/Joshua_Philips_Thesis.pdf.

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Genetic modifications of crops allow for a dramatic increase in crop production needed to meet the demands of the growing global population, whilst also enhancing nutrition and addressing challenges, such as pests, diseases and climate change. This research investigated the detection and mitigation of DNA methylation, which is a hallmark of gene silencing that hinders the development of genetically modified crops.

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Wu, Mengchu. "The Epigenetic Silencing of PMP24 During the Progression of Prostate Cancer from an Androgen-Dependent to Androgen-Independent State in the LNCAP Cell Model: a Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/209.

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One important objective of prostate cancer (PCa) research is to understand the molecular basis underlying the progression of these cancers from an androgen dependent to an androgen independent state. Hypermethylation of the promoter CpG islands is associated with the transcriptional silencing of specific gene sets in each tumor type and subtype. Transcriptional silencing of antitumor genes via CpG island hypermethylation could be a mechanism mediating PCa progression from an androgen-dependent to an androgen-independent state. Hypermethylation associated gene silencing has been reported for a

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Sánchez-Rodríguez, Francisco. "Role of RNase III enzymes and 3D chromatin structure in nitrogen-fixing symbiosis of Medicago truncatula." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASB022.

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La symbiose rhizobium-légumineuse (RLS) permet aux légumineuses de croître dans des sols pauvres en azote grâce à la formation de nodules racinaires abritant des rhizobia fixateurs d'azote. La nodulation implique, entre autres, l'expression des gènes qui codent pour des peptides NCR (« Nodule-Specific Cysteine-Rich Peptides ») ainsi que des modifications épigénétiques, incluant des variations de ploïdie, l'ouverture de la chromatine et des modifications des histones et des profils de méthylation de l'ADN. De plus, la voie de méthylation de l'ADN dépendante des petits ARN interférents de 24 nuc

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