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Dissertations / Theses on the topic 'RNA helicase A'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Fritz, Sarah E. "Molecular basis of the DExH-box RNA helicase RNA helicase A (RHA/DHX9) in eukaryotic protein synthesis." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437413252.

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2

Ranji, Arnaz K. "Mechanistic insights into translational modulation of selected RNAs by RNA helicase A." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299537544.

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3

Hahn, Daniela. "Brr2 RNA helicase and its protein and RNA interactions." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5775.

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The dynamic rearrangements of RNA and protein complexes and the fidelity of pre-mRNA splicing are governed by DExD/H-box ATPases. One of the spliceosomal ATPases, Brr2, is believed to facilitate conformational rearrangements during spliceosome activation and disassembly. It features an unusual architecture, with two consecutive helicase-cassettes, each comprising a helicase and a Sec63 domain. Only the N-terminal cassette exhibits catalytic activity. By contrast, the C-terminal half of Brr2 engages in protein interactions. Amongst interacting proteins are the Prp2 and Prp16 helicases. The work

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4

Kujat, Choy Sonya Louise. "A redox-regulated RNA helicase gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60315.pdf.

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5

Magee, Wendy Colleen. "Characterization of a cyanobacterial RNA helicase gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq22631.pdf.

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6

Grierson, Patrick Michael. "The BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337865492.

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7

Putnam, Andrea A. "MECHANISM OF RNA DUPLEX UNWINDING BY THE OLIGOMERIC DEAD-BOX RNA HELICASE DED1P." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1449225623.

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8

Yu, Esther Huiting. "Characterization of a cold shock cyanobacterial RNA helicase protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0004/MQ40129.pdf.

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9

Williams, Margaret Fairman. "Biochemical Characterization of the DExH/D RNA Helicase NPH-II." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1227651466.

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10

Carter, Christie. "The RNA Helicase p68 Regulates Transcription by Facilitating Chromatin Remodeling." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/biology_diss/60.

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P68 is a prototypical member of the DEAD box RNA helicase family. Implicated in numerous functions such as cell proliferation, cancer metastasis, transcription regulation and pre-mRNA spllicing, p68 is a multifunctional protein whose roles are still not completely understood. In the studies presented, we found that p68 was an important regulator of numerous cancer related genes. This study focuses on the cancer related genes Snail and hTERT. We show that p68 binds to the promoter and a downstream region within each gene, suggesting that p68 operates via the same mechanism with both genes.

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11

Gregersen, Lea Haarup [Verfasser]. "Functional Characterization of the RNA Helicase MOV10 / Lea Haarup Gregersen." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1047336774/34.

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12

Jackson, Ryan N. "Structural and Functional Characterization of the Essential RNA Helicase Mtr4." DigitalCommons@USU, 2012. https://digitalcommons.usu.edu/etd/1414.

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The essential protein Mtr4 is a conserved Ski2-like RNA helicase that maintains the integrity of nuclear RNA by promoting the 3' end decay of a wide variety of RNA substrates. Mtr4 activates the multi-protein exosome in RNA processing, surveillance, and turnover pathways by unwinding secondary structure and/or displacing associated proteins from RNA substrates. While Mtr4 may be able to promote decay independently, it is often associated with large multi-protein assemblies. Specifically, Mtr4 is the largest member of the TRAMP (Trf4/Air2/Mtr4 polyadenylation) complex which targets a plethora o

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13

Lin, Chunru. "Functional Role of Dead-Box P68 RNA Helicase in Gene Expression." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/10.

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How tumor cells migrate and metastasize from primary sites requires four major steps: invasion, intravasation, extravasation and proliferation from micrometastases to malignant tumor. The initiation of tumor cell invasion requires Epithelial-Mesenchymal Transition (EMT), by which tumor cells lose cell-cell interactions and gain the ability of migration. The gene expression profile during the EMT process has been extensively investigated to study the initiation of EMT. In our studies, we indicated that tyrosine phosphorylation of human p68 RNA helicase positively associated with the malignant

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14

Johnson, Jacqueline M. "Structural and Biochemical Characterization of the Frequency-Interacting RNA Helicase FRH." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4678.

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RNA is a molecular messenger of the cell, essential to many cellular pathways and processes. In order to maintain functionality, RNA is processed and modified by protein complexes such as the exosome and associated proteins. The exosome-mediated RNA processing or degradation both require a Ski-2 like helicase to function. One such helicase is the Frequency-interacting RNA Helicase (FRH), an essential RNA helicase from Neurospora Crassa. FRH is homologous to the Saccharomyces cerevisiae Mtr4 from the Ski2-like family of RNA helicases. Sequence alignments between FRH and Ski2-like family helicas

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15

Novoa, Carolina. "RecQ-like helicase SGS1 counteracts DNA : RNA hybrid induced genome instability." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/60964.

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Dividing cells are constantly under threat from both endogenous and exogenous DNA damaging stresses that can lead to mutations and structural variations in DNA. One contributor to genome instability is three-stranded DNA:RNA hybrid structures called R-loops. Though R-loops are known to induce DNA damage and DNA replication stress, it is unclear whether they are recognized and processed by an established DNA repair pathway prior to inducing DNA breaks. Canonically, DNA repair proteins work downstream of R-loop-induced DNA damage to stimulate repair and suppress genome instability. Recently, the

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16

Nashchekin, Dmitri. "A Y-box protein/RNA helicase complex links mRNP assembly on the gene to mRNA translation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-811-8/.

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17

Weaver, Paul L. "Characterization of a putative RNA helicase, Dbp3p, in ribosomal RNA processing and ribosome biogenesis in Saccharomyces Cerevisiae /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu148794750113696.

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18

Liu, Chia Yi. "Tyrosine Phosphorylation of p68 RNA Helicase Promotes Metastasis in Colon Cancer Progression." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_diss/117.

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The initiation of cancer metastasis usually requires Epithelial-Mesenchymal Transition (EMT), by which tumor cells lose cell-cell interactions and gain the ability of migration and invasion. Previous study demonstrated that p68 RNA helicase, a prototypical member of the DEAD-box RNA helicases, functions as a mediator to promote platelet-derived growth factor (PDGF)-induced EMT through facilitating nuclear translocation of β-catenin in colon cancer cells. In this context, p68 RNA helicase was found to be phosphorylated at the tyrosine 593 residue (referred as phosphor-p68) by c-Abl kinase, and

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19

Kuznicki, Kathleen. "The function of the germline rna helicase (GLH) genes in caenorhabditis elegans." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9988682.

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20

Chuang, Ray-Yuan. "Requirement of a putative RNA helicase, ded1p, for translation in saccharomyces cerevisiae /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487948158625166.

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21

Marushchak, Oksana. "Biophysical investigation of G-quadruplex recognition by the N-terminal construct of RNA helicase associated with AU-rich element (RHAU)." American Society for Biochemistry and Molecular Biology (United States), 2013. http://hdl.handle.net/1993/23958.

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G-quadruplexes, characterized by stacked G-tetrad rings held together by Hoogsteen hydrogen bonds, have been visualized in human cells and implicated in transcriptional and translational control, telomere maintenance and disease. RHA Helicase associated with AU-rich element (RHAU), a DEAH-box helicase, is a major G-quadruplex resolvase in human cell lysates. It binds G-quadruplexes through the RHAU specific motif in its N-terminus. In order to investigate the recognition of G-quadruplexes by helicases, the binding between the N-terminal construct of RHAU, RHAU53-105, and the DNA analog of the

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22

Tedeschi, Frank A. Tedeschi. "IDENTIFICATION OF CELLULAR RNA BINDING SITES OF DEAD-BOX HELICASES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1531217057171378.

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23

Smith, Wendell A. "A structural and functional analysis of the nuclear import of RNA Helicase A /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3112873.

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24

Chong, Jean-Leon. "Functional characterization of Ded1p, a DExD/H box RNA helicase, in saccharomyces cerevisiae." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1092284292.

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25

Kapadia, Fehmida. "Analyses of the thymidylate synthase promoter and an RNA helicase required for mRNA export." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117635126.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 179 p.; also includes graphics. Includes bibliographical references (p. 155-179). Available online via OhioLINK's ETD Center

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26

Boralli, Camila Maria dos Santos. "Estudo do envolvimento da RNA helicase Sub2 na reação de splicing em Trypanosoma brucei." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-03102018-092702/.

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A excisão de sequencias intrônicas dos precursores de mRNAs é um passo crítico durante a expressão gênica eucariótica. Essa reação é catalisada pelo complexo macromolecular denominado spliceossomo, composto por partículas ribonucleoproteicas nucleares (U1, U2, U4/U6, U5 snRNPs), além de inúmeros fatores associados. Em tripanossomatídeos, os genes são transcritos em longas unidades policistrônicas e a reação de SL trans-splicing é requerida para geração de transcritos monocistrônicos maduros. O spliceossomo é uma maquinaria altamente dinâmica e parte das mudanças conformacionais ocorridas neste

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27

Thompson, Michael Ryan Haden. "An Evaluation of Host Factors as Novel Therapeutic Targets During Influenza Infection Using RNA Technologies." CSUSB ScholarWorks, 2018. https://scholarworks.lib.csusb.edu/etd/721.

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Influenza A is a single-stranded, multi-segmented, negative sense RNA virus of the family Orthomyxoviridae and is the causative agent of seasonal Influenza. Influenza viruses cause significant impacts on a global scale regarding public health and economics. Annual influenza virus infections in the United States account for over 200,000 hospitalizations, up to 49,000 deaths, and an $87.1 billion economic burden. Influenza A virus has caused several pandemics since the turn of the 20th century. The effects of Influenza on public health and economics, compounded with low efficacy of the annual va

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28

Okeke, Chukwuemeka Franklin. "The Expression of p68 Protein in the Australian Zebra Finch Brain Across Development." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/biology_theses/10.

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Steroid hormones and receptors play a role in regulating biological events underlying brain development and sexual differentiation. Current evidence indicates that circulating sex steroid hormones are not entirely responsible for development of neural sex differences in song birds such as the zebra finch. p68, as a coactivator specific for estrogen receptor alpha (ERα) and an essential factor in early tissue development and maturation might play a role in sexual differentiation. Zebra finches have a sexually dimorphic song control nuclei in the brain, males have larger song nuclei than females

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29

Han, Zhong. "Characterization of the mechanisms of transcription termination by the helicase Sen1." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS202/document.

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La transcription cachée est un phénomène répandu aussi bien chez les eucaryotes que chez les procaryotes. Elle se caractérise par une production massive d’ARNs non-codants au niveau de régions non-annotées du génome et est potentiellement dangereuse pour la cellule car elle peut interférer avec l’expression normale des gènes. Chez S. cerevisiae, l’hélicase Sen1 induit la terminaison précoce de la transcription non-codante et joue ainsi un rôle clé dans le contrôle de la transcription cachée. Sen1 est très conservée et des mutations dans son homologue humain, senataxin (SETX), ont été associées

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30

Bolinger, Cheryl Giles. "Study of translation control by a RNA helicase A-responsive post-transcriptional control element in Retroviridae." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1226513076.

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31

Dey, Heena T. "Functional Study of the Threonine Phosphorylation and the Transcriptional Coactivator Role of P68 RNA Helicase." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_diss/123.

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P68 RNA helicase is a RNA helicase and an ATPase belonging to the DEAD-box family. It is important for the growth of normal cells, and is implicated in diverse functions ranging from pre-mRNA splicing, transcriptional activation to cell proliferation, and early organ development. The protein is documented to be phosphorylated at several amino-acid residues. It was previously demonstrated in several cancer cell-lines that p68 gets phosphorylated at threonine residues during treatments with TNF-α and TRAIL. In this study, the role of threonine phosphorylation of p68 under the treatment of anti-c

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32

Sharma, Amit. "Functional control of HIV-1 post-transcriptional gene expression by host cell factors." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1330658547.

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33

Tokonzaba, Etienne. "Molecular mechanism of SV40 large tumor antigen helicase /." Connect to abstract via ProQuest. Full text is not available online, 2007.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 82-92; 128-134). Online version available via ProQuest Digital Dissertations.

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34

Izzo, Annalisa. "Characterization of MLE RNA helicase, a subunit of the Dosage Compensation Complex (DCC) in Drosophila melanogaster." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-52515.

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35

Hanet, Aoife Julia [Verfasser], and Doron [Akademischer Betreuer] Rapaport. "Roles of the putative RNA helicase HELZ in mRNA regulation / Aoife Julia Hanet ; Betreuer: Doron Rapaport." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1205002057/34.

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36

Chen, Yanling. "Role of Pfa1p and Gno1p/PINX1, co-factors of the RNA helicase Prp43p, during ribosome biogenesis." Toulouse 3, 2012. http://thesesups.ups-tlse.fr/1829/.

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De nombreuses hélicases d'ARN sont requises pour la synthèse des ribosomes. Il a précédemment été démontré que Prp43p, hélicase d'ARN de type DEAH impliquée dans l'épissage, était également requise chez la levure pour la synthèse de la petite et de la grande sous-unité du ribosome et était associée à la plupart des particules pré-ribosomiques. Nous émettons l'hypothèse que Prp43p participe au remodelage de plusieurs particules pré-ribosomiques. Durant la première partie de ma thèse, j'ai contribué à la démonstration que la protéine à domaine G-patch Pfa1p se fixe directement sur Prp43p, pour s

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37

Ferraioli, Domenico. "Assessment and relevance of the putative DNA/RNA helicase Schlafen-11 in ovarian and breast cancer." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1324/document.

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Schlafen 11 (SLFN11) est une ADN/ARN hélicase décrite pour la première fois pour son rôle dans le développement et la différenciation des thymocytes chez la souris. Elle fait partie d'une famille de protéines présentant divers degrés d'homologie entre les espèces, mais qu’est présente de façon constante chez les mammifères. Le rôle de cette ADN/ARN hélicase, SLFN11, a été associé de façon causale à la sensibilité de réponse aux différents agents alkylants (agents endommageant l'ADN, les inhibiteurs de topo-isomérase I et II) dans le NCI-60. Dans la première étude, nous avons développé un proto

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38

Qian, Shuiming. "Study of retrovirus and host interplay: RNA helicase A and microRNA pathway modulate viral gene expression." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1236621870.

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39

Spinelli, Pietro. "Functional studies of the RNA helicases Vasa and Tdrd9 in the piRNA pathway." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV047/document.

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Les protéines Piwi sont exprimées dans les gonades (testicules et ovaires) des animaux où elles s'associent à des petits ARN nommés piRNAs (Piwi-interaction RNAs) et répriment les éléments transposables, défendant ainsi de l'intégrité du génome. En effet, les animaux knock-out pour les protéines Piwi montrent une perte de piRNAs et une activation des éléments transposables avec des conséquences catastrophiques: l'arrêt du développement des cellules germinales, due potentiellement à des dommages du génome qui entraîne l'infertilité. Le « Silencing » est réalisé soit par l'activité endonucléase

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40

Yang, Liuqing. "A Novel Function of DEAD Box p68 RNA Helicase In Tumor Cell Proliferation And Epithelial-Mesenchymal Transition." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/8.

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Activities of the DEAD box (Asp-Glu-Ala-Asp) family of proteins- including RNA-dependent ATPase and RNA helicase- function in all organisms to sculpt RNA-RNA duplex and RNA-protein complexes, ensuring that necessary rearrangements are rapidly and properly resolved during genetic information processing. Identified as a prototypic member of the DEAD box family and documented as an ATPase and RNA helicase, p68 plays essential and diverse functions in the control of gene expression ranging from pre-mRNA/rRNA processing and mRNA decay/stability to transcriptional activation and initiation. Despite

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41

Bosco, Bartolomeo. "Exploring DHX30, an RNA helicase that coordinates cytoplasmic translation and mitochondrial function contributing to cancer cell survival." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/277809.

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Many recent studies established a potential role for p53 in translational control of many transcripts through the modulation of the expression of several microRNAs, RNA binding proteins (RBPs), translation factors, or of ribosome biogenesis factors. To establish the relevance of translation control in p53-dependent apoptosis our group recently compared by polysome profiling two cell lines, SJSA1 and HCT116, undergoing respectively p53-dependent apoptosis and cell cycle arrest in response to the treatment with Nutlin-3, a selective activator of p53. Examining the markedly different, treatment-i

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42

Banerjee, Daipayan. "CHARACTERIZATION OF G-PATCH MOTIF CONTRIBUTION TO PRP43 FUNCTION IN THE PRE-MESSENGER RNA SPLICING AND RIBOSOMAL RNA BIOGENESIS PATHWAYS." UKnowledge, 2013. http://uknowledge.uky.edu/biology_etds/10.

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The DExD/H-box protein Prp43 is essential for two biological processes: nucleoplasmic pre-mRNA splicing and nucleolar rRNA maturation. The biological basis for the temporal and spatial regulation of Prp43 remains elusive. The Spp382/Ntr1, Sqs1/Pfa1 and Pxr1/Gno1 G-patch proteins bind to and activate the Prp43 DExD/H box-helicase in pre-mRNA splicing (Spp382) and rRNA processing (Sqs1, Pxr1). These Prp43-interacting proteins each contain the G-patch domain, a conserved sequence of ~48 amino acids that includes 6 highly conserved glycine (G) residues. Five annotated G-patch proteins in baker’s y

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43

Rabhi, Makhlouf. "Mécanismes et régulation d'une ARN hélicase essentielle chez E. coli : le facteur de terminaison de la transcription bactérienne Rho." Thesis, Orléans, 2011. http://www.theses.fr/2011ORLE2008.

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Chez E. coli, Rho est un facteur essentiel qui contrôle l’expression de multiples unités transcriptionnelles via le phénomène de terminaison de la transcription. Rho est un moteur moléculaire ATP-dépendant ayant une activité ARN hélicase caractéristique de sa capacité à dissocier des obstacles (comme l’ARN polymérase) lors de sa translocation le long de sa piste ARN. Il existe différentes structures de Rho en interaction avec l’ARN qui suggèrent des mécanismes de translocation contradictoires. Afin de mieux comprendre ces mécanismes, nous avons utilisé deux approches complémentaires pour ident

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44

Leonaitė-Pittelkov, Bronislava Verfasser], and Elena [Akademischer Betreuer] [Conti. "Structural and biochemical studies of the S. cerevisiae DNA/RNA helicase Sen1 / Bronislava Leonaitė-Pittelkov ; Betreuer: Elena Conti." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1156852005/34.

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45

Strittmatter, Lisa Maria. "Development of in vitro iCLIP techniques to study spliceosome remodelling by RNA helicases." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289976.

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Pre-mRNA (precursor messenger RNA) splicing is a fundamental process in eukaryotic gene expression. In order to catalyse the excision of the intervening intronic sequence between two exons, the spliceosome is assembled stepwise on the pre-mRNA substrate. This ribonucleoprotein machine is extremely dynamic: both its activation and the progression through the catalytic stages require extensive compositional and structural remodelling. The first part of this thesis aims at understanding how the spliceosome is activated after assembly. When this work was started, the GTPase Snu114 was thought to a

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46

Rodela, Emily Cristina, and Emily Cristina Rodela. "The DEAD-Box Helicase Family Member Ded1 Plays a Role in the Cellular Stress Response." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/621842.

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The DEAD-Box RNA helicase family is a conserved group of enzymes that function in gene expression through ATP-dependent RNA unwinding and ribonucleoprotein (RNP) remodeling. DEAD-Box helicases function in multiple cellular processes, including pre-mRNA processing, translation, mRNA export, and mRNA decay. Although DEAD-Box proteins are critical for gene expression, much of their mechanistic activities are poorly understood. DEAD-Box proteins have increasingly been linked to tumorigenesis in humans, and better defining their activity at the mechanistic level will aid in understanding the underl

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47

Roberts, Tiffiney Marie. "Redundant structural motifs in a unique retroviral posttranscriptional control element mediate a novel mechanism of translational enhancement." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1066927045.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xix, 165 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Kathleen Boris-Lawrie, Dept. of Molecular, Cellular and Developmental Biology. Includes bibliographical references (p. 148-165).

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48

Jia, Huijue. "Molecular Mechanism of the TRAMP Complex." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1310139879.

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49

Anastasov, Nataša. "Cold shock induced genes in Yersinia enterocolitica processing of Csp mRNA and transcriptional regulation of DEAD box RNA helicase /." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969378726.

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50

Wang, Haizhen. "The Nucleocytoplasmic Shuttling Functions of P68 in Cancer Cell Migration and Proliferation." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/113.

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P68 RNA helicase (p68), as a DEAD family protein, is a typical RNA helicase protein. P68 functions in many other biological processes, which include the regulations of the gene transcription, cell proliferation and cell differentiation. In our group, Y593 phosphorylated p68 was found to have a function in the epithelial mesynchymal transition, which is an important process for cancer metastasis. In the present study, we found that p68 is a nucleocytoplasmic shuttling protein. The protein carries two functional nuclear exporting signal sequences and two nuclear localization signal sequences. Ca

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