Academic literature on the topic 'RNA interference'

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Journal articles on the topic "RNA interference"

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Downward, Julian. "RNA interference." BMJ 328, no. 7450 (May 20, 2004): 1245–48. http://dx.doi.org/10.1136/bmj.328.7450.1245.

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FIGUEROA, BRYAN E., and ROBERT M. FRIEDLANDER. "RNA Interference." Neurosurgery 54, no. 3 (March 2004): NA. http://dx.doi.org/10.1227/01.neu.0000309606.99960.fd.

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Hoh, Yin Kiong. "RNA Interference." American Biology Teacher 76, no. 6 (August 1, 2014): 373–77. http://dx.doi.org/10.1525/abt.2014.76.6.4.

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Hannon, Gregory J. "RNA interference." Nature 418, no. 6894 (July 2002): 244–51. http://dx.doi.org/10.1038/418244a.

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Sioud, Mouldy, and Abdelali Haoudi. "RNA Interference." Journal of Biomedicine and Biotechnology 2006 (2006): 1–2. http://dx.doi.org/10.1155/jbb/2006/89018.

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ARNAUD, CELIA. "RNA INTERFERENCE." Chemical & Engineering News 84, no. 41 (October 9, 2006): 8. http://dx.doi.org/10.1021/cen-v084n041.p008.

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Sweeney, B. P., and M. Z. Michel. "RNA interference." European Journal of Anaesthesiology 25, no. 7 (July 2008): 525–27. http://dx.doi.org/10.1017/s0265021508003992.

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Moyer, Paula. "RNA INTERFERENCE." Neurology Today 3, no. 7 (July 2003): 30–33. http://dx.doi.org/10.1097/00132985-200307000-00012.

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Pe'ery, T. "RNA interference." Methods 30, no. 4 (August 2003): 287–88. http://dx.doi.org/10.1016/s1046-2023(03)00035-5.

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Eccleston, Alex, and Angela K. Eggleston. "RNA interference." Nature 431, no. 7006 (September 2004): 337. http://dx.doi.org/10.1038/431337a.

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Dissertations / Theses on the topic "RNA interference"

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Schultes, Stephan. "Nanoparticles for RNA Interference." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-113293.

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Shah, Samit Friedman Simon H. "Light activated RNA interference." Diss., UMK access, 2007.

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Thesis (Ph. D.)--School of Pharmacy and Dept. of Chemistry. University of Missouri--Kansas City, 2007.
"A dissertation in pharmaceutical science and chemistry." Advisor: Simon H. Friedman. Typescript. Vita. Description based on contents viewed July 16, 2008; title from "catalog record" of the print edition. Includes bibliographical references (leaves 206-220). Online version of the print edition.
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Marr, Edward John. "RNA interference (RNAi) for selective gene silencing in Astigmatid mites." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25722.

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Psoroptic mange, caused by the Astigmatid mite Psoroptes ovis, is an ectoparasitic disease of significant economic importance to agriculture on a global scale and poses a serious welfare concern. With the current chemotherapeutic controls considered unsustainable, there is pressing need for novel control strategies. RNA interference has been proposed as a potential high throughput approach for the identification of novel therapeutic targets with high specificity, speed and at a relatively low cost compared to the existing methods. The presence of the components of the RNA interference (RNAi) pathway in P. ovis was first confirmed through in silico analyses of the P. ovis transcriptome and, following development of a non-invasive immersion method of double stranded RNA (dsRNA) delivery, gene silencing by RNAi was demonstrated in P. ovis. Statistically-significant reduction of transcript level was measured for the three genes targeted: P. ovis mite group 2 allergen (Pso o 2), P. ovis mu class glutathione S-transferase (PoGST-mu1) and P. ovis beta tubulin (Poβtub). This is the first demonstration of gene silencing by RNAi in P. ovis and provides a key mechanism for mining transcriptomic and genomic datasets in the future for novel targets of intervention against P. ovis. The first assessment of gene silencing was also performed in two related Astigmatid mites of high medical importance; the European house dust mite Dermatophagoides pteronyssinus and the scabies mite Sarcoptes scabiei. A statistically-significant reduction in expression of a D. pteronyssinus mu class glutathione S-transferase (DpGST-mu1) transcript was observed. No significant reduction in expression of a S. scabiei mu class glutathione S-transferase (SsGST-mu1) transcript was observed. Additionally, microRNAs (miRNAs) from the related miRNA pathway were identified in a P. ovis small RNA sample and were sequenced and annotated.
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Shoji, Masanobu. "RNA interference during spermatogenesis in mice." Kyoto University, 2006. http://hdl.handle.net/2433/143821.

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Pereira, Tiago Campos. "Estudo de possiveis aplicações médicas da interferencia por RNA." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316861.

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Orientadores: Iscia Teresinha Lopes-Cendes, Ivan de Godoy Maia
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-04T19:04:59Z (GMT). No. of bitstreams: 1 Pereira_TiagoCampos_D.pdf: 3895694 bytes, checksum: d999bfc92e9a2e2c757db34bbfc7d7fa (MD5) Previous issue date: 2005
Doutorado
Genetica Animal e Evolução
Doutor em Genetica e Biologia Molecular
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Aitken, Amelia. "Blocking the RNA Interference Pathway Improves Oncolytic Virus Therapy." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36821.

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Oncolytic viruses are novel candidates for cancer therapy and their efficacy relies on their capacity to overcome the host’s anti-viral barriers. In mammalian cells, the anti-viral response involves a protein-signaling cascade known as the interferon pathway, which alerts the immune system and limits the propagation of infection. Given that most cancer cells have defects in this pathway, they are susceptible to viral infection and responsive to oncolytic virotherapy. For reasons that remain unknown, many cancers are still refractory to oncolytic viruses, which suggests the existence of additional antiviral mechanisms. In this study, we investigate the potential involvement of an alternative antiviral pathway in cancer cells. Given that insects and plants rely on the RNA silencing pathway for their anti-viral protection, we investigated the presence of a similar mechanism in cancer cells. We found viral genome-derived small RNAs in various cancer cell lines upon infection, which is indicative of an RNA-mediated antiviral response. Also, various viruses encode suppressors of the RNA interference pathway. To determine if an oncolytic virus could benefit from such a factor, we engineered an oncolytic virus variant to encode the Nodamura virus B2 protein, a known inhibitor of RNA silencing-mediated immune responses. Using this virus, we observed enhanced cytotoxicity in 33 out of the 38 human cancer cell lines tested. Furthermore, our results show inhibition of viral genome cleavage and altered microRNA processing by our B2-expressing oncolytic virus. Taken together, our data suggests the blockade of RNA silencing antiviral pathways and/or antiviral microRNA processing improves the efficacy of our B2-encoding virus in a cell-line specific manner. Overall, our results establish the improved potential of our novel virus therapy and demonstrate for the first time the involvement of RNA pathways in the antiviral defense of cancer cells.
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Garbutt, Jennifer S. "RNA interference in insects : persistence and uptake of double-stranded RNA and activation of RNAi genes." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548101.

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RNA interference (RNAi) is a eukaryotic phenomenon where short double-stranded RNA molecules (dsRNAs) repress homologous sequences. In insects RNAi has been widely observed and has proved extremely useful as a reverse genetics tool to elucidate the function of newly identified genes, as well as showing potential as a novel insecticide. Unfortunately, however, not all insect species are equally susceptible to RNAi. This thesis explores whether persistence of dsRNA in insect hemolymph, uptake of dsRNA into insect tissue, or activation of RNAi genes could be limiting factors in RNAi experiments. Trials were conducted with the tobacco hornworm, Manduca sexta, a species in which experimental difficulty has been experienced with RNAi protocols and the German cockroach, Blattella germanica, which is known to be highly susceptible to experimental RNAi. In M. sexta larvae dsRNA disappeared rapidly from the hemolymph in vivo. By comparison, exogenous dsRNA persisted longer in the hemolymph of B. germanica adults. These findings lead me to propose that the rate of persistence of dsRNA in insect hemolymph may be a key factor in determining the susceptibility of insect species to RNAi. Despite such rapid breakdown of dsRNA in M. sexta larvae uptake of exogenous dsRNA into hemocytes, fat body and midgut could be detected by quantitative RT-PCR in vivo and was experimentally investigated in hemocytes in vivo and in vitro using fluorescently labelled dsRNA. Furthermore, quantitative-RT-PCR revealed that the expression of two M. sexta RNAi genes dicer-2 and argonaute-2 (partial sequences of which were isolated during this study) was specifically upregulated in response to injection with dsRNA.
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Lee, Hung-chiu. "Synthetic RNA interference against influenza A virus." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35537814.

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Mankin, Danielle N. "MC3R and MC4R Knockdown via RNA Interference." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_theses/37.

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Melanocortins (MCs) play an important role in feeding, metabolism, and energy expenditure. While melanocortin receptor (MCR) mRNA has been found in the mesolimbic dopamine (DA) pathway, the ability of melanocortins to regulate feeding and other behaviors through actions on the mesolimbic DA system have not been examined. Short-hairpin RNAs (shRNAs) were created targeting MC3R and MC4R and were tested via in vitro studies for their ability to knockdown their target receptor. A total of three shRNAs were created targeting each receptor, and each shRNA caused successful knockdown. These shRNAs are tools that can be used for future in vivo studies to examine the various behavioral effects of melanocortins on the mesolimbic DA pathway.
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Lee, Hung-chiu, and 李洪釗. "Synthetic RNA interference against influenza A virus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B35537814.

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Books on the topic "RNA interference"

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Sioud, Mouldy, ed. RNA Interference. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-1538-5.

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Min, Wei-Ping, and Thomas Ichim, eds. RNA Interference. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-588-0.

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Paddison, Patrick J., and Peter K. Vogt, eds. RNA Interference. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-75157-1.

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Johnson, Paul H., ed. RNA Interference. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9780470923733.

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R, Engelke David, and Rossi John J, eds. RNA interference. San Diego: Elsevier Academic Press, 2005.

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Vogt, P. K. (Peter K.), 1932- and SpringerLink (Online service), eds. RNA Interference. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2008.

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Harper, Scott Q., ed. RNA Interference Techniques. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-114-7.

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T, Lyland Roger, and Browning Irving B, eds. RNA interference research progress. New York: Nova Science Publishers, 2008.

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Ross, Engelke David, ed. RNA interference (RNAi): Nuts & bolts of RNAi technology. [Eagleville, PA]: DNA Press, 2003.

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Gott, Jonatha M., ed. RNA Interference, Editing, and Modification. Totowa, NJ: Humana Press, 2004. http://dx.doi.org/10.1385/1592597750.

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Book chapters on the topic "RNA interference"

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Nakashima, Yuko, Naoko Abe, Yoshihiro Ito, and Hiroshi Abe. "Nanostructured RNAs for RNA Interference." In RNA Interference, 17–36. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1538-5_2.

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Kwon, Jae-Sung, Raviraj Thakur, Steven T. Wereley, J. David Schall, Paul T. Mikulski, Kathleen E. Ryan, Pamela L. Keating, et al. "RNA Interference (RNAi)." In Encyclopedia of Nanotechnology, 2238. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100714.

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Leppla, Norman C., Bastiaan M. Drees, Allan T. Showler, John L. Capinera, Jorge E. Peña, Catharine M. Mannion, F. William Howard, et al. "RNA Interference (RNAi)." In Encyclopedia of Entomology, 3195–96. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_3417.

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Das, Shreya, Chandrani Dey, Santanu Chakraborty, and Arunima Sengupta. "RNA Interference (RNAi)." In Exploring Medical Biotechnology- in vivo, in vitro, in silico, 231–59. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/9781003302131-21.

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Birchler, James A. "RNA Interference: What is it?" In RNA Interference, 1–11. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470923733.ch1.

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Huang, Faqing, C. J. Yu, and Yanlin Guo. "Nucleic Acids as Regulatory Molecules." In RNA Interference, 12–49. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470923733.ch2.

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Wiederholt, Kristin A., and Adam N. Harris. "Use of SiRNA Oligonucleotides to Study Gene Function." In RNA Interference, 50–75. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470923733.ch3.

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Beijersbergen, Roderick L., and Oliver C. Steinbach. "Genome Scanning by RNA Interference." In RNA Interference, 76–122. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470923733.ch4.

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Johnson, Paul H., Diane Frank, Kunyuan Cui, Roger Adami, Harry Wang, Michael Houston, and Steven C. Quay. "Discovery of New SiRNA Delivery Agents." In RNA Interference, 123–73. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470923733.ch5.

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Salem, Aliasger K., and Mark A. Behlke. "SiRNA Delivery Vehicles." In RNA Interference, 174–215. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470923733.ch6.

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Conference papers on the topic "RNA interference"

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Bachkova, I. K., S. A. Zhukov, M. S. Kupryushkin, M. A. Zenkova, E. L. Chernolovskaya, and I. V. Chernikov. "THE EFFECT OF MESYL PHOSPHORAMIDATE MODIFICATION ON SIRNA POTENCY IN VITRO." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-295.

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The introduction of chemical modifications into the composition of small interfering RNA (siRNA) improves its biological properties, but can inhibit the RNA interference (RNAi) process. Therefore, in this work, we screened the patterns of modification of siRNAs with mesyl groups (μ), covering 70% of positions in siRNAs. In most positions, μ did not inhibit the RNAi process, so the introduction of μ can potentially improve its biological properties in vivo.
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Yoon, June-Sun. "Identification of key players in RNA interference." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94699.

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Puthenveetil, Sujiet, Landon Whitby, Olena Maydanovych, Brittany Haudenschild, and Peter A. Beal. "Modified RNA for the study of enzymes involved in RNA editing, the innate immune response and RNA interference." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507127.

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Aguirre-Rojas, Lina M. "Silencing ofLaccase2inDectes texanus(Coleoptera: Cerambycidae) by RNA interference." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.113330.

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Shatters, Jr., Robert. "Application of RNA interference (RNAi) as an invasive pest control strategy in Florida." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94273.

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Desai, Suresh. "Control of pests of canola using RNA interference technologies." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.93852.

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Zhang, Jianzhen. "Effect of dsRNase on the efficiency of RNA interference." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94702.

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Hogancamp, Tessily, Anne Ruffing, and John Gladden. "Developing RNA Interference in Rhodotorula toruloides for Gene Knockdown." In Proposed for presentation at the 11th International Conference on Biomolecular Engineering (ICBE) held January 6-9, 2021 in virtual, virtual, US. US DOE, 2020. http://dx.doi.org/10.2172/1837621.

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Hogancamp, Tessily, Anne Ruffing, and John Gladden. "Developing RNA Interference in Rhodotorula toruloides for Gene Knockdown." In Proposed for presentation at the 11th International Conference on Biomolecular Engineering (ICBE) held January 6-9, 2021 in virtual, virtual. US DOE, 2020. http://dx.doi.org/10.2172/1837801.

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He, Mu-yang, Hao-jie Cao, Le Wang, and Shou-jing Zhao. "Construction of Ginseng CS Gene RNA Interference Plant Expression Vector." In 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). IEEE, 2012. http://dx.doi.org/10.1109/icbeb.2012.115.

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Reports on the topic "RNA interference"

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Mo, Yin-Yuan. Dysregulation of RNA Interference in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 2006. http://dx.doi.org/10.21236/ada460075.

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Mo, Yi-Yuan. Dysregulation of RNA Interference in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 2007. http://dx.doi.org/10.21236/ada476970.

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Siolas, Despina, and Gregory Hannon. Using RNA Interference to Reveal Genetic Vulnerabilities in Human Cancer Cells. Fort Belvoir, VA: Defense Technical Information Center, July 2005. http://dx.doi.org/10.21236/ada443917.

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Burow, Matthew E. RNA Interference Library Approach to Identifying Mechanisms of Ovarian Cancer Metastasis. Fort Belvoir, VA: Defense Technical Information Center, July 2008. http://dx.doi.org/10.21236/ada517354.

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Thompson, James. Novel MHC Class II Breast Cancer Vaccine Using RNA Interference (RNAi) to Down-Regulate Invariant Chain (Ii). Fort Belvoir, VA: Defense Technical Information Center, May 2004. http://dx.doi.org/10.21236/ada425843.

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Thompson, James A. Novel MHC Class II Breast Cancer Vaccine Using RNA Interference (RNAi) to Down Regulate Invariant Chain (li). Fort Belvoir, VA: Defense Technical Information Center, May 2006. http://dx.doi.org/10.21236/ada462403.

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Guney, Isil. Dissecting Androgen-Dependent and Independent Signaling Pathways Using RNA Interference-Based Functional Genomics in Human Cells. Fort Belvoir, VA: Defense Technical Information Center, June 2008. http://dx.doi.org/10.21236/ada495676.

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Guney, Isil. Dissecting Androgen-Dependent and Independent Signaling Pathways Using RNA Interference-Based Functional Genomics in Human Cells. Fort Belvoir, VA: Defense Technical Information Center, June 2009. http://dx.doi.org/10.21236/ada505263.

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Yadav, Kamlesh K. Discovery of Prostate Cancer Tumor Suppressors and Mediators of MDV3100 Resistance through in Vivo RNA Interference Screen. Fort Belvoir, VA: Defense Technical Information Center, May 2014. http://dx.doi.org/10.21236/ada621085.

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Meidan, Rina, Jorge Flores, Keith Inskeep, and David Wolfenson. Controlling the bovine ovarian cycle by disrupting the endothelin system in corpora lutea and follicles with novel approaches: RNA interference (RNAi) and intra-luteal Atrigel implants. United States Department of Agriculture, June 2006. http://dx.doi.org/10.32747/2006.7695594.bard.

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In summary intensive studies carried out this year in both the US and Israel had established the methodology necessary for the achievement of the specific aims of the original proposal. Two complementary approaches to effectively neutralize the luteal ET- system were developed. In light of recent publications indicating that ET-2 might also have a physiological role in ovulation, the objectives of the original proposal have even more significant. Not only were the technologies to neutralize the luteal endothelin system developed in these studies, but additional important implications about the role of ET-1 were revealed. For example, direct early inhibitory effects of PGF2α were unmasked. It is possible that these early direct inhibitory effects could be related to functional aspects of luteal regression, while the effects observed after 12 hours of the PGF2α injection and that reversed by the ET receptor antagonist, could coincide with structural aspects of regression. Nevertheless, overall, the results clearly indicate that serum progesterone concentrations can effectively be elevated by the receptor antagonist which of great practical importance.
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