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Dissertations / Theses on the topic 'RNA localization and translation'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Ciolli, Mattioli Camilla. "Post-transcriptional mechanisms contributing to RNA and protein localization: study of local translation and alternative 3′UTRs in induced neurons." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20702.

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Die asymmetrische Verteilung von mRNA und Proteinen innerhalb einer Zelle definiert die Polarität. Dies ermöglicht eine strikte Regulierung der Genexpression in Raum und Zeit. Ich habe in dieser Arbeit untersucht, wie das Soma und die Neuriten in induzierten Neuronen sich hinsichtlich ihres Transkriptoms und Translatoms unterscheiden. Eine räumliche ribosomale Profilanalyse ergab, dass die Hälfte des lokalen Proteoms durch die mRNA-Lokalisierung und der lokalen Translation definiert wird. Dies sind Prozesse, die durch die synergistische Aktivität von trans- und cis-agierenden Elementen du

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2

Vicario, Annalisa. "Analysis of the molecular mechanisms of BDNF mRNA localization and traslation in neurons." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3664.

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2008/2009<br>La regolazione dell’espressione genica rappresenta uno fenomeno fondamentale per garantire la sopravvivenza e la corretta funzione cellulare. In strutture complesse ed altamente specializzate come il sistema nervoso, la grande varietà morfologica e funzionale, la rapidità di interscambio di comunicazioni e di adattamento richiede un’altrettanto fine regolazione spazio-temporale dell’espressione genica. I livelli di regolazione sono molteplici e includono lo splicing alternativo, la regolazione del turnover degli mRNA, modifiche post-traduzionali ed il controllo traduzionale. La se

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3

Rongo, Christopher Gabriel. "The role of RNA localization and translational regulation in Drosophila germ cell determination." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/10562.

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4

Ohler, Uwe [Gutachter], Florian [Gutachter] Heyd, and Chakrabarti [Gutachter] Sutapa. "Post-transcriptional mechanisms contributing to RNA and protein localization: study of local translation and alternative 3′UTRs in induced neurons / Gutachter: Uwe Ohler, Florian Heyd, Chakrabarti Sutapa." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1199930695/34.

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5

Maderazo, Alan Baer. "A Study on the Cellular Localization of Factors Involved in Yeast Nonsense-Mediated mRNA Decay and their Mechanisms of Control on Nonsense mRNA Translation: a Dissertation." eScholarship@UMMS, 2000. https://escholarship.umassmed.edu/gsbs_diss/105.

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Nonsense-mediated mRNA decay (NMD) is an important mRNA surveillance mechanism conserved in eukaryotes. This thesis explores several interesting aspects of the NMD pathway. One important aspect of NMD which is presently the subject of intense controversy is the subcellular localization of NMD. In one set of experiments, the decay kinetics of the ade2-1 and pgk1 nonsense mRNAs (substrates for NMD) were investigated in response to activating the NMD pathway to determine if cytoplasmic nonsense mRNAs are immune to NMD in the yeast system. The results of these studies demonstrated that activation

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6

Eliscovich, Carolina. "Spindle-Localized CPE-Mediated Translation Controls Mediotic Chromosome Segregation." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7123.

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La progresión meiótica y el desarrollo embrionario temprano están programados, en parte, por la activación tradcuccional de mRNAs maternos como lo son los que codifican para las proteinas de ciclina B1 o mos. Estos mRNAs no son traducidos al mismo tiempo ni en el mismo lugar. Por lo contrario, su traducción está especificamente regulada por elementos de poliadenilación citoplasmática (CPEs) presentes en sus 3'UTRs. Los elementos CPEs reclutan a la proteina de unión a CPE (CPE-binding protein CPEB (Colegrove-Otero et al., 2005; de Moor et al., 2005; Mendez and Richter, 2001; Richter, 2007)). Es

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7

Reynolds, Joanna Elizabeth. "Initiation of hepatitis C virus RNA translation." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264546.

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8

Hunt, Sarah Louise. "Cellular proteins required for rhinovirus RNA translation." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313880.

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9

Lempke, Carola. "Internal initiation of translation of cardiovirus RNA." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624267.

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10

Donlevy, Alison. "Regulation of RNA translation by phenethyl isothiocyanate." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/362491/.

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Phenethyl isothiocyanate (PEITC) is a dietary phytochemical that has received considerable interest for its potential chemopreventive/therapeutic anti -cancer activity. PEITC inhibits cancer cell proliferation and/or survival in vitro, suppresses angiogenesis and decreases tumour growth in vivo with little toxicity. However, the mechanisms by which PEITC exerts its anti-cancer effects are not known. The goal of this project was to investigate the hypothesis that anti-cancer effects ofPEITC may involve inhibition of mRNA translation. Effects of PEITC on global mRNA translation were first studie

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11

Iwakawa, Hirooki. "Translation and RNA replication mechanisms of Dianthovirus." Kyoto University, 2010. http://hdl.handle.net/2433/120491.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第15448号<br>農博第1833号<br>新制||農||982(附属図書館)<br>学位論文||H22||N4547(農学部図書室)<br>27926<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授奥野哲郎, 教授遠藤隆, 教授荒木崇<br>学位規則第4条第1項該当

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12

Saini, Harleen. "Intron and Small RNA Localization in Mammalian Neurons." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1044.

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RNA molecules are diverse in form and function. They include messenger RNAs (mRNAs) that are templates for proteins, splice products such as introns that can generate functional noncoding RNAs, and a slew of smaller RNAs such as transfer RNAs (tRNAs) that help decode mRNAs into proteins. RNAs can show distinct patterns of subcellular localization that play an important role in protein localization. However, RNA distribution in cells is incompletely understood, with prior studies focusing primarily on RNAs that are long (>200 nucleotides), fully processed, and polyadenylated. We examined the di

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13

Johnston, Julie Catherine. "In vitro translation of cucumber necrosis virus RNA." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/28969.

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The in vitro translation products directed by cucumber necrosis virus (CNV) RNA were analyzed in both rabbit reticulocyte lysate and wheat germ extract cell-free translation systems. In rabbit reticulocyte lysates, one major protein of ca. 33 Mr was produced. In wheat germ extracts, four proteins of ca. 41, 33, 21 and 20 Mr were produced. Hybrid-arrested translation (HART) studies using synthetic CNV antisense RNA corresponding to the entire CNV genome demonstrated that the four major proteins synthesized from CNV virion RNA in wheat germ extracts are virus-specific translation products. The g

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14

Starmer, Joshua Mr. "What can RNA hybrids tell us about translation?" NCSU, 2006. http://www.lib.ncsu.edu/theses/available/etd-10202006-155443/.

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Molecular biologists have been observing interactions between messenger RNA (mRNA) molecules and other non-coding RNA molecules for quite some time. Here I revisit some of the classical hybridizations between the 16S ribosomal RNA (rRNA) and mRNA during initiation, as well as investigate the interactions between small interfering RNA (siRNA) molecules and mRNA. In reviewing rRNA-mRNA interactions, I observed that the majority of both bacterial and eukaryote genes can bind at the start codon. This novel result lead to a method for improving genome annotation as well as a new theory of translati

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15

Howell, Michael Terence. "The mechanism of initiation of poliovirus RNA translation." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386094.

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16

Borman, Andrew Mark. "Internal initiation of translation of human rhinovirus RNA." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281908.

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17

Qin, Daoming. "Role of 16S Ribosomal RNA in Translation Initiation." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299007063.

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18

Leipuvienė, Ramunė. "Frameshifting as a tool in analysis of transfer RNA modification and translation /." Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-302.

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19

Deumer, Claudia D. "RNA-binding proteins in yeast mitochondria." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2002. http://nbn-resolving.de/urn:nbn:de:swb:14-1035897639531-83407.

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This work focused on the further characterisation of Idhp and of the Krebs cycle enzymes citrate synthase 1 (Cit1p) and malate dehydrogenase 1 (Mdh1p) both of which have been identified as RNA-binding proteins without known RNA recognition motifs. Besides analysing their effects on mitochondrial translation and their organisation in protein complexes the work focused on the characterisation of the RNA-binding properties of recombinant Cit1p and Mdh1p: · Cit1p and Mdh1p play no essential role in mitochondrial protein synthesis. · Idhp is in a complex of molecular weight larger than the cytochro

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20

Daughenbaugh, Katie Finney. "The role of VPg in translation of calicivirus RNA." Diss., Montana State University, 2005. http://etd.lib.montana.edu/etd/2005/daughenbaugh/DaughenbaughK1205.pdf.

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21

Méthot, Nathalie. "RNA and protein interactions by eIF4B during translation initiation." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40401.

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One of the most enduring questions pertaining to eukaryotic translation initiation is how the 40S ribosomal subunit recognizes and binds at or near the cap-structure of mRNAs. Eukaryotic initiation factor 4B (eIF4B) is one of the factors that are required for this step of protein synthesis. eIF4B stimulates the RNA helicase activity of eIF4A and eIF4F, melting RNA secondary structure in the 5$ sp prime$ untranslated region (UTR), and is thus believed to contribute to ribosome binding by creating an area of single-stranded RNA accessible to the 40S ribosomal subunit We studied the mechanism of

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22

Brown, E. C. "Cellular proteins involved in translation of human rhinovirus RNA." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596963.

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Translation of picornavirus RNA takes place by internal initiation, determined by the presence of an internal ribosome entry site (IRES) in the 5'-untranslated region of the genomic RNA. Efficient translation from the human rhinovirus-2 (HRV-2) IRES is dependent on host cell <I>trans</I>-acting factors. These include unr, p38 and polypyrimidine tract binding protein (PTB). This thesis details the investigation into how these factors act to promote translation from the HRV-2 IRES. Unr, an RNA-binding protein with five cold-shock domains (CSDs), binds to the HRV-2 IRES and this interaction was s

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23

Pizzinga, Mariavittoria. "Granules of translation factor mRNAs and their potential role in the localisation of the translation machinery to regions of polarised growth." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/granules-of-translation-factor-mrnas-and-their-potential-role-in-the-localisation-of-the-translation-machinery-to-regions-of-polarised-growth(9cb42e69-3c8c-4f10-b79f-ba8261be4430).html.

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The subcellular localisation of mRNA is a widespread mechanism to determine the fate of mRNAs in eukaryotes. Translationally repressed mRNAs localise to P-bodies and stress granules where their decay and storage, respectively, are directed. In a study from the Ashe lab, specific mRNAs were identified to localise, in actively growing S. cerevisiae, to cytoplasmic granules that do not seem to be related to P-bodies or stress granules but appear to be associated with active translation (Lui et al., 2014).It is possible that this might represent a strategy to co-regulate the expression of proteins

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24

Doyle, Olivia E. "Cajal bodies sites of RNA polymer II localization and modification /." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080652.

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25

Martina, Chieca. "APOBEC1 OLIGOMERIZATION AND LOCALIZATION IN RNA EDITING AND LENTIVIRAL RESTRICTION." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1105192.

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APOBEC1 oligomerization and localization in RNA editing and lentiviral restriction In the past years, the emerging field of epitranscriptomic regulation of the cell has reignited interest in APOBEC1, an RNA editing enzyme. APOBEC1 is physiologically part of the editosome complex that deaminates a CAA codon into UAA Stop codon in the mRNA of Apolipoprotein B (ApoB), a protein essential for the transport of lipids in the blood. Yet, ApoB is the only fully characterized target of APOBEC1 among hundreds of recently identified ones. In the years of my PhD I have thus investigated APOBEC1 from t

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26

Butsch, Melinda Sue. "Control of Retroviral Translation and Relationship to Genomic RNA Packaging." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1029510697.

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27

Cimatti, Laura. "Long Non-Coding RNA Antisense to Uchl1 Increases Its Protein Translation and Identifies a New Class of Protein Translation Activators." Doctoral thesis, SISSA, 2013. http://hdl.handle.net/20.500.11767/3922.

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Thanks to continuous technical advances in the sequencing field nowadays we know that most of the mammalian genome is transcribed. This generates a vast repertoire of transcripts that includes protein-coding messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs) and repetitive sequences, such as Short Interspersed Nuclear Elements (SINEs). A large percentage of ncRNAs is nuclear-enriched with unknown function. LncRNAs may be transcribed in antisense direction and may form sense/antisense pairs by pairing with an mRNA from the opposite strand to regulate chromatin conformation, transcription an

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28

Dienstbier, Martin. "Recognition of mRNA localization signals in Drosophila development." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608472.

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29

Yoon, Young J. "Role of Xenopus staufen and kinesin I in vegetal RNA localization /." View online version; access limited to Brown University users, 2005. http://wwwlib.umi.com/dissertations/fullcit/3174705.

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30

Bourdeau-Julien, Isabelle. "ALS-associated RNA-binding protein FUS and mRNA translation regulation." Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/68742.

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Des mutations dans plusieurs gènes ont été liés à la sclérose latérale amyotrophique (SLA),en particulier dans celui codant pour la protéine Fused in Sarcoma (FUS). Les mutations sont retrouvées dans la partie codant pour le signal de localisation nucléaire, rendant la protéine anormalement abondante dans le cytoplasme. Combiné à d’autres observations, ça suggère qu’un gain de fonction toxique de FUS dans le cytoplasme serait à l’origine de la neurodégénérescence. La SLA est une maladie neurodégénérative qui affecte les neurones moteurs et cause une paralysie progressive. Les mécanismes molécu

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31

Halsell, Susan Richardson Lipshitz Howard D. Lipshitz Howard D. "Expression and localization of Hsp83 RNA in the early Drosophila embryo /." Diss., Pasadena, Calif. : California Institute of Technology, 1995. http://resolver.caltech.edu/CaltechETD:etd-10092007-075248.

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32

RIBEIRO, GABRIELA CASTELO BRANCO. "MACHINE TRANSLATION EVALUATION FOR THE SOFTWARE LOCALIZATION INDUSTRY: A CASE STUDY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2006. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=9105@1.

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COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR<br>Este estudo foi motivado pela utilização, ainda em caráter experimental, de um tradutor automático por uma empresa multinacional de localização de software. A fim de contribuir para essa iniciativa pioneira no país, propomos uma avaliação do programa, enfocando as implicações da utilização desta tecnologia no processo de localização de software. Empregamos a taxonomia proposta pelo FEMTI (Framework for the Evaluation of Machine Translation in ISLE), desenvolvida especialmente para a avaliação de tradução automática, com bas

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33

Kumari, Sunita. "Role of RNA G-quadruplexes within 5' UTRs in translation regulation." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612262.

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34

Swift, Michael A. "Identification of RNA-binding proteins associated with H19 lncRNA translation avoidance." Scholarship @ Claremont, 2016. http://scholarship.claremont.edu/cmc_theses/1302.

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High throughput RNA-sequencing data has revealed a cellular transcriptome that represents a much larger part of the genome than was thought even 10 years ago. The newfound transcripts are not translated to protein and a few are known to have essential functions regulating gene expression. However, most non-coding RNAs in the transcriptome have no identified function or mechanism of action. H19 is a long non-coding RNA (lncRNA) that looks much like an mRNA with a 5’ methyl cap and a polyA tail, but it is not translated. H19 is associated with cell proliferation and most human cancers. The mecha

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35

Sweet, Thomas Jeffrey. "New Insights Into the Relationship Between Messenger RNA Translation and Degradation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1321298653.

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36

Leen, Eoin. "Structural insights into the transcription and translation of murine norovirus RNA." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11173.

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Noroviruses are positive-sense single-stranded RNA viruses which, in humans, cause rapid onset diarrhoea and vomiting. There is an estimated 21 million cases of noroviral gastroenteritis in the United States per year. The work in this thesis has focused on two noroviral proteins, the viral protein genome-linked (VPg), and the viral RNA dependent RNA polymerase (NS7pol). The VPg protein is covalently linked to the 5' end of the noroviral genome and is a key component of translation and replication initiation in noroviruses. Using Nuclear magnetic resonance spectroscopy (NMR) we have analysed th

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37

SARAWANEEYARUK, SIRIRUK. "Studies on Cap-Independent Translation and RNA Replication Mechanisms of Dianthovirus." Kyoto University, 2010. http://hdl.handle.net/2433/131903.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第15733号<br>農博第1845号<br>新制||農||985(附属図書館)<br>学位論文||H22||N4468(農学部図書室)<br>28278<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授奥野哲郎, 教授遠藤隆, 教授左子芳彦<br>学位規則第4条第1項該当

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Karakasiliotis, Ioannis. "Analysis of RNA-protein interactions involved in calicivirus translation and replication." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/1304.

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The interaction of host-cell nucleic acid-binding proteins with the genomes of positive-stranded RNA viruses is known to play a role in the translation and replication of many viruses. To date, however, the characterisation of similar interactions with the genomes of members of the Caliciviridae family has been limited to in vitro binding analysis. In this study, feline calicivirus (FCV) and murine norovirus (MNV) have been used as model systems to identify and characterise the role of host-cell factors that interact with the viral RNA and RNA structures that regulate virus replication. It was

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39

Krech, Sabine. "Translation of the genomic RNA of hepatitis A virus in vitro /." [S.l : s.n.], 1988. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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40

Nashchekin, Dmitri. "A Y-box protein/RNA helicase complex links mRNP assembly on the gene to mRNA translation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-811-8/.

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41

Presnyak, Vladimir. "Effects of Codon Usage on mRNA Translation and Decay." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1427387336.

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Gillespie, Doreen. "The role of homeless in RNA transport and localization during Drosophila oogenesis /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10305.

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43

Zimmermann, C. "Regulation of mRNA localization, stability and local translation in sympathetic neuron axons." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1405619/.

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Polarity is dependent on the asymmetric distribution of proteins, which can be especially challenging in neurons as the nucleus, where transcription takes place, can be far away from the final location of the protein. One essential mechanism by which protein compartmentalization can be achieved is through the targeting of specific mRNA transcripts to specific cellular regions where they are locally translated. Neurotrophin 3 (NT3) is secreted by blood vessels and is required for the initial growth of proximal sympathetic neuron axons along the vasculature. NGF on the other hand, is secreted by

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44

Cridge, Andrew Graham, and n/a. "Characterization of the eukaryotic translation termination sequence element." University of Otago. Department of Biochemistry, 2005. http://adt.otago.ac.nz./public/adt-NZDU20060804.095722.

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Termination of protein synthesis occurs in response to the translocation of a stop codon (UAA, UAG or UGA) into the A site of the ribosome. Unlike sense codons, stop signals in the mRNA are recognized by two classes of specialized proteins called release factors (RFs): the class I or decoding RF, which recognizes the stop codon and promotes peptidyl-tRNA hydrolysis and class II RF, a G-protein that promotes the dissociation of the decoding RF from the ribosome. The discovery that stop codons are decoded by a protein factor rather than a specific tRNA opened up the possibility that the signal f

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45

Gill, Kirsty. "Elucidating the molecular mechanism that determines the specific localisation of gurken mRNA during Drosophila development." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:01e61a3d-b29f-4766-b8c8-81552e5cd11d.

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mRNA localisation is a widely used mechanism for achieving temporal-spatial restriction of protein expression and is essential during development to establish cell polarity. mRNA localisation is particularly well studied in the Drosophila egg chamber where gurken mRNA is localised to the dorsal-anterior corner of the oocyte in a Dynein-dependent process that establishes the anterior-posterior and dorsal-ventral axes of the future embryo. An RNA stem-loop called the gurken localisation signal is necessary and sufficient to drive gurken localisation through interactions with a specific complemen

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Crandall, Jacob N. "Ribosomal RNA Mutations that Inhibit the Activity of Transfer-Messenger RNA of Stalled Ribosomes." Diss., CLICK HERE for online access, 2010. http://contentdm.lib.byu.edu/ETD/image/etd3535.pdf.

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47

Bilali, Loubna. "Localization Training: Towards an Industry-based Requirements-Gathering Model." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532649023272877.

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48

Leipuviene, Ramune. "Frameshifting as a tool in analysis of transfer RNA modification and translation." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-302.

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Studies of ribosomal reading frame maintenance are often based on frameshift mutation suppression experiments. In this thesis, suppression of a frameshift mutation in Salmonella enterica serovar Typhimurium by a tRNA and a ribosomal protein are described. The +1 frameshift mutation hisC3072 (that contains an extra G in a run of Gs) is corrected by mutations in the argU gene coding for the minor tRNAArgmnm5UCU. The altered tRNAArgmnm5UCU has a decreased stability and reduced aminoacylation due to changed secondary and/or tertiary structure. Protein sequencing revealed that during the translatio

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Fred, Rikard G. "The Role of RNA Binding Proteins in Insulin Messenger Stability and Translation." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130234.

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Although the reason for insufficient release of insulin in diabetes mellitus may vary depending on the type and stage of the disease, it is of vital importance that an amplified insulin biosynthesis can meet the increased need during periods of hyperglycemia. The insulin mRNA is highly abundant in beta cells and changes in insulin mRNA levels are, at least in part, controlled by altered rates of mRNA degradation. Since the mechanisms behind the control of insulin messenger stability and translation are still largely obscure, the work presented in this thesis therefore aimed to further investig

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Subhan, Syed Abdus. "Dissecting the initiation factors required for translation initiation on feline calicivirus RNA." Thesis, University of Surrey, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543924.

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