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Relevant bibliographies by topics / RNA Nanotechnology / Dissertations / Theses

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Dissertations / Theses on the topic 'RNA Nanotechnology'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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Consult the top 21 dissertations / theses for your research on the topic 'RNA Nanotechnology.'

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1

Guo, Sijin. "RNA Nanoparticle as A Safe and Effective Drug Delivery Platform for Cancer Therapy." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1561719043509709.

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2

Saxena, Pooja. "Development of RNA-free particles of Cowpea mosaic virus for applications in nanotechnology." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/42355/.

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A method for the efficient production of RNA-free particles of Cowpea mosaic virus (CPMV) has been developed. These are generated by co-expression of the precursor of the coat proteins (VP60) and the viral proteinase (24K) using the highly-efficient plant expression system, CPMV-HT, in the model plant Nicotiana benthamiana. Particles thus produced were shown to be identical to CPMV on the outside and devoid of RNA on the inside and were hence named CPMV empty virus-like particles (eVLPs). The availability of large quantities of purified eVLPs represents a significant milestone in the developme

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3

Parlea, Lorena Georgeta. "Towards Automating Structural Analysis of Complex RNA Molecules and Some Applications In Nanotechnology." Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1429316311.

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4

Novikova, Irina V. "Paranemic and Receptor-Loop RNA Motifs: Versatile Interactions for Biosensing Platforms and Nanotechnology Scaffolds." Bowling Green State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1288300501.

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5

Shu, Yi. "Assembly of Phi29 pRNA Nanoparticles for Gene or Drug Delivery and for Application in Nanotechnology and Nanomedicine." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1336683831.

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6

Leonard, Marissa. "Overcoming Breast Cancer Metastasis with Novel RNA Aptamers." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1572879601351414.

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7

Shav-Tal, Yaron, Noa Neufeld, Nicole Bieberstein, et al. "The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-180908.

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RNA processing events that take place on the transcribed pre-mRNA include capping, splicing, editing, 3′ processing, and polyadenylation. Most of these processes occur co-transcriptionally while the RNA polymerase II (Pol II) enzyme is engaged in transcriptional elongation. How Pol II elongation rates are influenced by splicing is not well understood. We generated a family of inducible gene constructs containing increasing numbers of introns and exons, which were stably integrated in human cells to serve as actively transcribing gene loci. By monitoring the association of the transcription and

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8

Shav-Tal, Yaron, Noa Neufeld, Nicole Bieberstein, et al. "The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing." Public Library of Science, 2011. https://tud.qucosa.de/id/qucosa%3A28933.

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RNA processing events that take place on the transcribed pre-mRNA include capping, splicing, editing, 3′ processing, and polyadenylation. Most of these processes occur co-transcriptionally while the RNA polymerase II (Pol II) enzyme is engaged in transcriptional elongation. How Pol II elongation rates are influenced by splicing is not well understood. We generated a family of inducible gene constructs containing increasing numbers of introns and exons, which were stably integrated in human cells to serve as actively transcribing gene loci. By monitoring the association of the transcription and

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9

Singer, Anthony N. "A New Approach to the Development of an RSV Anti-viral Targeted Nanocarrier for Dual Inhibition of Viral Infection and Replication." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7712.

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Respiratory Syncytial Virus (RSV) is a potentially life-threatening respiratory pathogen that infects approximately 64 million children and immunocompromised adults globally per year. Currently, there is a need for prophylactic and therapeutic approaches effective against primary and secondary RSV infections. This project focuses on the development of a simple, smart, and scalable anti-RSV nanotherapeutic that combines novel cellular antiviral defense mechanisms targeting the inhibition of viral fusion and replication. An ICAM-1 targeted liposomal nanocarrier will be synthesized and coated wit

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10

Binzel, Daniel W. "Thermodynamics and Kinetics of the Three-Way Junction of Phi29 Motor pRNA and its Assembly into Nanoparticles for Therapeutic Delivery to Prostate Cancer." UKnowledge, 2016. http://uknowledge.uky.edu/pharmacy_etds/53.

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The emerging field of RNA nanotechnology necessitates creation of functional RNA nanoparticles, but has been limited by particle instability. Previously, it was found the three-way junction (3WJ) of the Phi29 DNA packaging motor pRNA was found to be ultra-stable and assemble in solution without the presence of metal ions. The three-way junction is composed of three short oligo RNA strands and proven to be thermodynamically stable. Here the assembly mechanism, thermodynamic and enzymatic stabilities, and kinetics are examined in order to understand the stability behind this unique motif. Thermo

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11

Xiao, Feng. "Molecular Mechanism of Connector-RNA Interaction of Bacteriophage Phi29 DNA Packaging Motor and Applications of Motor Components in Nanotechnology." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1250622038.

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12

Afonin, Kirill A. "Design and Characterization of Novel Bio-Sensor Platform for Sequence Specific, Label-Free, Fluorescent Detection of Native RNA Moledcules." Bowling Green State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1206395144.

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13

Kristoffersson, Anders. "Rolling circle transcription on smallest size double stranded DNA minicircles." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134082.

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The RNA polymerase T7 is utilized as a component of motor complexes in DNA nanotechnology due to its high promotor specificity, the lack of external transcription factors and its very high processivity, but there is no experience of its application on small double stranded DNA circles. Circular templates from 210 to 126 bp in circumference sharing a common promotor termination motif were synthesized and transcription was monitored at end point on gel and in real time with a 2’ O methyl RNA molecular beacon. The RNAP T7 was found to be able to utilize circular dsDNA templates down to 126 bp wit

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14

Jasinski, Daniel L. "Development of Diverse Size and Shape RNA Nanoparticles and Investigation of their Physicochemical Properties for Optimized Drug Delivery." UKnowledge, 2017. http://uknowledge.uky.edu/pharmacy_etds/72.

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RNA nanotechnology is an emerging field that holds great promise for advancing drug delivery and materials science. Recently, RNA nanoparticles have seen increased use as an in vivo delivery system. RNA was once thought to have little potential for in vivo use due to biological and thermodynamic stability issues. However, these issues have been solved by: (1) Finding of a thermodynamically stable three-way junction (3WJ) motif; (2) Chemical modifications to RNA confer enzymatic stability in vivo; and (3) the finding that RNA nanoparticles exhibit low immunogenicity in vivo. In vivo biodistribu

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15

Teplensky, Michelle. "Metal-organic frameworks as a platform for therapeutic delivery." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/279081.

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16

Hanewich-Hollatz, Mikhail Henning. "Conditional Guide RNAs: Programmable Conditional Regulation of CRISPR/Cas Function via Dynamic RNA Nanotechnology." Thesis, 2020. https://thesis.library.caltech.edu/11888/2/Hanewich-Hollatz_Mikhail_2020.pdf.

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<p>A guide RNA (gRNA) directs the function of a CRISPR protein effector to a target gene of choice, providing a versatile programmable platform for engineering diverse modes of synthetic regulation (edit, silence, induce, bind). However, the fact that gRNAs are constitutively active places limitations on the ability to confine gRNA activity to a desired location and time. To achieve programmable control over the scope of gRNA activity, here we apply principles from dynamic RNA nanotechnology to engineer conditional guide RNAs (cgRNAs) whose activity is dependent on the presence or absence of a

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17

"RNA Aptamer-Based Systems for Pathogen Detection and Biomolecule Synthesis." Doctoral diss., 2020. http://hdl.handle.net/2286/R.I.63037.

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abstract: RNA aptamers adopt tertiary structures that enable them to bind to specific ligands. This capability has enabled aptamers to be used for a variety of diagnostic, therapeutic, and regulatory applications. This dissertation focuses on the use RNA aptamers in two biological applications: (1) nucleic acid diagnostic assays and (2) scaffolding of enzymatic pathways. First, sensors for detecting arbitrary target RNAs based the fluorogenic RNA aptamer Broccoli are designed and validated. Studies of three different sensor designs reveal that toehold-initiated Broccoli-based aptasensors provi

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18

Chiappini, Dottore Ciro. "Porous silicon nanoneedles for intracellular delivery of small interfering RNA." Thesis, 2011. http://hdl.handle.net/2152/ETD-UT-2011-05-2671.

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The rational and directed delivery of genetic material to the cell is a formidable tool to investigate the phenotypic effects of gene expression regulation and a promising therapeutic strategy for genetic defects. RNA interference constitutes a versatile approach to gene silencing. Despite the development of numerous strategies the transfection of small interfering RNA (siRNA) is highly dependent on cell type and conditions. Direct physical access to the intracellular compartment is a promising path for high efficiency delivery independently of cell type and conditions. Silicon nanowires grant

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19

Phua, Kyle K. L. "Development of Delivery Strategies Facilitating Broad Application of Messenger RNA Tumor Vaccine." Diss., 2014. http://hdl.handle.net/10161/8642.

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<p>Genetic modification of dendritic cells with plasmid DNA is plagued with low transfection efficiencies because DNA taken up by non-dividing dendritic cells rarely reaches the nucleus. But this difficulty can be overcome by the use of messenger RNA (mRNA), which exerts its biological function in the cytoplasm and obviates the need to enter the nucleus. Since pioneering work of Boczkwoski et al, the ex-vivo application of mRNA-transfected dendritic cells as a vaccine has been evaluated in numerous phase I trials worldwide and is still currently being actively optimized in clinical trials. </p

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20

"Computational Design and Study of Structural and Dynamic Nucleic Acid Systems." Doctoral diss., 2019. http://hdl.handle.net/2286/R.I.53645.

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abstract: DNA and RNA are generally regarded as one of the central molecules in molecular biology. Recent advancements in the field of DNA/RNA nanotechnology witnessed the success of usage of DNA/RNA as programmable molecules to construct nano-objects with predefined shapes and dynamic molecular machines for various functions. From the perspective of structural design with nucleic acid, there are basically two types of assembly method, DNA tile based assembly and DNA origami based assembly, used to construct infinite-sized crystal structures and finite-sized molecular structures. The assemble

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21

Reboud, Julien. "MISE AU POINT D'UN FORMAT DE PUCES A CELLULES POUR L'ANALYSE PHENOTYPIQUE A HAUT-CONTENU." Phd thesis, 2006. http://tel.archives-ouvertes.fr/tel-00092909.

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Aujourd'hui la recherche en biologie dispose d'une masse d'informations génomiques considérable qu'il faut comprendre fonctionnellement pour faire émerger de nouveaux concepts, qui formeront le berceau de nouvelles thérapies. Ces études mettent en jeu des mécanismes contrôlés à l'échelle moléculaire et nécessitent le traitement d'informations à haut-débit et de manière parallèle. Les travaux pluridisciplinaires présentés ont permis de mettre au point une technologie miniaturisée de culture de cellules en gouttes matricées sur supports solides, pour tester l'action des molécules sur le comporte

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