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Dissertations / Theses on the topic 'RNA ; Proteins ; DNA replication'

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Published: 4 June 2021

Last updated: 16 February 2022

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1

Langley, Alexander Richard. "Interactions between non-coding Y RNAs and proteins in the context of the initiation of human chromosomal DNA replication." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609101.

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2

Hillukkala, T. (Tomi). "Roles of DNA polymerase epsilon and TopBP1 in DNA replication and damage response." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514282922.

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Abstract During DNA replication cells accurately copy their DNA to transfer the genetic information to daughter cells. DNA polymerases synthesise the new DNA strand using the old strand as a template. Other functions of DNA polymerases are recombination linked and DNA iamage repair linked DNA synthesis, regulation of replication complex formation and regulation of transcription – a process in which the genetic information is transformed into an RNA sequence needed to guide protein synthesis. In this study, the TopBP1 protein was shown to associate with DNA polymerase epsilon. TopBP1 contains

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3

Tsao, Theresa Tsun-Hui. "Towards the development of transgenic banana bunchy top virus (BBTV)-resistant banana plants : interference with replication." Queensland University of Technology, 2008. http://eprints.qut.edu.au/17031/.

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Banana bunchy top virus (BBTV) causes one of the most devastating diseases of banana. Transgenic virus resistance is now considered one of the most promising strategies to control BBTV. Pathogen-derived resistance (PDR) strategies have been applied successfully to generate plants that are resistant to numerous different viruses, primarily against those viruses with RNA genomes. BBTV is a circular, single-stranded (css) DNA virus of the family Nanoviridae, which is closely related to the family Geminiviridae. Although there are some successful examples of PDR against geminiviruses, PDR against

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4

Tokonzaba, Etienne. "Molecular mechanism of SV40 large tumor antigen helicase /." Connect to abstract via ProQuest. Full text is not available online, 2007.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 82-92; 128-134). Online version available via ProQuest Digital Dissertations.

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5

Leriche, Mélissa. "Mise en évidence d’une interaction entre la protéine 53BP1 et les fragments d’Okazaki." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS065.

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Le maintien de l’intégrité du génome est un processus crucial à la vie cellulaire. Ce n’est que récemment que les protéines de liaison à l’ARN (« RNA-binding protein » ou RBP) ont été montré être impliquées dans ce processus. En présence d’ADN endommagé, les RBP régulent l’expression des gènes de réponse aux dommages de l’ADN et contrôlent le destin cellulaire. Elles jouent également un rôle plus direct dans la prévention et la réparation des dommages de l’ADN. De plus, des ARN sont présents aux sites de dommages de l’ADN et participent au maintien de l’intégrité du génome. Ainsi, le laboratoi

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6

Pageau, Gayle Jeannette. "Maintenance of Constitutive and Inactive X Heterochromatin in Cancer and a Link to BRCA1: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/331.

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The development of cancer is a multi-step process which involves a series of events, including activation of oncogenes and loss of tumor suppressor function, leading to cell immortalization and misregulated proliferation. In the last few years, the importance of epigenetic defects in cancer development has become increasingly recognized. While most epigenetic studies focus on silencing of tumor suppressors, this thesis addresses defects in the maintenance of silenced heterochromatin in cancer, particularly breast cancer. Breast cancer is a leading cause of cancer in women and many familial

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7

Pageau, Gayle Jeannette. "Maintenance of Constitutive and Inactive X Heterochromatin in Cancer and a Link to BRCA1: A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/331.

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The development of cancer is a multi-step process which involves a series of events, including activation of oncogenes and loss of tumor suppressor function, leading to cell immortalization and misregulated proliferation. In the last few years, the importance of epigenetic defects in cancer development has become increasingly recognized. While most epigenetic studies focus on silencing of tumor suppressors, this thesis addresses defects in the maintenance of silenced heterochromatin in cancer, particularly breast cancer. Breast cancer is a leading cause of cancer in women and many familial

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8

Bailey, Daniel John. "Cellular proteins in picornavirus replication." Thesis, University of Reading, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298484.

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9

Komori, Hirofumi. "Structural studies on DNA-binding proteins : DNA replication initiator and DNA photolyase." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/150005.

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10

Antonopoulos, Ioanna H. "CHARACTERIZING RNA TRANSCRIPTION AND DNA REPLICATION VIA RAMAN CRYSTALLOGRAPHY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1428076280.

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11

Lassen, Matthew Gordon. "Identification of proteins involved in chloroplast DNA replication /." Diss., CLICK HERE for online access, 2004. http://contentdm.lib.byu.edu/ETD/image/etd633.pdf.

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12

Lassen, Matthew G. "Identification of Proteins Involved in Chloroplast DNA Replication." BYU ScholarsArchive, 2004. https://scholarsarchive.byu.edu/etd/221.

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Chapter 1 Chloroplast nucleoids (ct-nucleoids) are DNA/protein complexes involved in compacting the chloroplast genome, and may play a role in regulating DNA replication. Ct-nucleoids were isolated from young soybean plants and separated by 2-D gel electrophoresis. Gel spots were excised and analyzed by MALDI-ToF mass spectrometry, resulting in several protein identifications. The proteins identified all have functions unrelated to DNA replication. While some of these proteins may be due to contamination, it is possible that some of these proteins are dual-functional, playing direct roles in t

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13

Altaparmakova, Mary Collette. "Human papillomavirus early proteins and cellular DNA replication." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615159.

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14

Tomanicek, Stephen Joseph. "Crystallographic Studies of DNA Replication and Repair Proteins." University of Toledo / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1115325888.

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15

Mast, Christof. "Polymerization and replication of DNA/RNA in a thermal trap." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-175178.

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16

Peck, Vickie Marie. "DNA replication in Drosophila embryos: Proteins at the fork." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185786.

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Drosophila embryos provide a rich source of replicative enzymes. Also, the duration of 2 hour embryo DNA synthesis phase of the cell cycle is approximately 6-fold shorter than the more regulated 9 hour embryo S phase. Thus, Drosophila embryos are a good system in which to explore the mechanisms and regulation of DNA replication. Early stage, 2 hour embryos contain at least two distinct DNA polymerases, DNA polymerase α and δ, as determined by associated enzymatic activities (DNA primase and 3'-5' exonuclease), inhibitor studies, immunologic reactivity, and processivity measurements. The observ

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17

Gadkari, Varun V. "A Multi-Disciplinary Investigation of Essential DNA Replication Proteins." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492566624521622.

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18

Hill, G. R. "NMR studies of DNA and RNA binding proteins." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604060.

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HMG-D is a 112-residue, non-histone chromosomal protein from <i>Drosophila melanogaster </i>and is a member of the class of non-sequence specific HMGB proteins. The present project was based on the observation that other HMGB complexes that had been solved by NMR had a phenylalanine residue at a key interfacial location (corresponding to position 12 in HMG-D), whereas those like HMG-D that gave few intermolecular NOE cross peaks generally had a tyrosine at this location. This tyrosine was known to be involved in hydrogen-bonding to the DNA in a related complex that had been solved crystallogra

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19

Evans, Braun Tamara Zoe Marie. "The involvement of HCMV and cellular replication proteins in viral and cellular DNA replication." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608577.

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20

Berg, Linda. "Evolutionary Covariance Among DNA Replication Restart Primosome Genes." University of Dayton / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1342115880.

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21

Dao, Luan D. "Human papillomavirus segregation and replication /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/dao.pdf.

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22

Novac, Olivia. "Studies on origin binding proteins involved in mammalian DNA replication." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83084.

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The objective of this thesis is to investigate the proteins interacting with specific DNA sequences, termed origins of DNA replication in vivo. Two previously described origin binding proteins, OBA/Ku and CBP/14-3-3 were analyzed. Previously, Ku was shown to bind to A3/4, a 36-bp origin sequence, in vitro, and 14-3-3 isoforms were identified as cruciform binding proteins (CBP) which interact with cruciform structures present in mammalian replication origins.<br>Here, the in vivo association of Ku and 14-3-3 with mammalian origins of DNA replication was analyzed by studying its associati

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23

Matheos, Diamanto. "Origin binding proteins and their rose in mammalian DNA replication." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37777.

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A 186-bp fragment of ors8, a mammalian DNA replication origin, was previously identified as the minimal sequence required for origin function in vivo and in vitro. The 186-bp origin contains, among other features, an octamer motif, serving as the binding site for the transcription factor Oct-1, and an A3/4-homologous region, serving as the binding site for the origin binding protein, OBA. The research objective of this thesis is to investigate the role of Oct-1 and OBA in mammalian in vitro DNA replication.<br>Depletion of the Oct-1 protein inhibited in vitro DNA replication to basal levels. T

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24

Donovan, Shane. "The role of MCM proteins in budding yeast DNA replication." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267294.

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25

Liang, Debbie T. "Multiple roles of fission yeast MCM proteins in DNA replication /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3041400.

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26

Panaviene, Zivile Sliesaraviciute. "THE ROLE OF TOMBUSVIRUS REPLICASE PROTEINS AND RNA IN REPLICASE ASSEMBLY, REPLICATION AND RECOMBINATION." UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_diss/435.

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Tombusviruses are single, positive strand RNA viruses of plants, often associated with parasitic defective interfering (DI) RNAs. Two viral- coded gene products, namely p33 and p92, are required for tombusvirus replication. The overlapping domains of p33 and p92 contain an arginine/proline-rich (RPR) RNA binding motif. In this study, the role of RPR motif and viral RNA in tombusvirus replication and recombination, as well as involvement of viral RNA in tombusvirus replicase assembly was examined. Using site-directed mutagenesis I generated a series of RPR mutants of Cucumber necrosis tombusvir

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27

Morley, Stewart Anthony. "Interactions Between the Organellar Pol1A, Pol1B, and Twinkle DNA Replication Proteins and Their Role in Plant Organelle DNA Replication." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8128.

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Plants maintain organelle genomes that are descended from ancient microbes. Ages ago, these ancient microbes were engulfed by larger cells, beginning a process of co-evolution we now call the endo-symbiotic theory. Over time, DNA from the engulfed microbe was transferred to the genome of the larger engulfing cell, eventually losing the ability to be free-living, and establishing a permanent residency in the larger cell. Similarly, the larger cell came to rely so much on the microbe it had engulfed, that it too lost its ability to survive without it. Thus, mitochondria and plastids were born. N

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28

Tu, Zheng. "DNA replication-initiation proteins : novel cancer detection markers and anticancer targets /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20TU.

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29

Isoz, Isabelle. "Role of yeast DNA polymerase epsilon during DNA replication." Doctoral thesis, Umeå : Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1932.

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30

Pathak, Kunj Bihari. "CHARACTERIZATION OF VIRAL AND HOST PROTEINS AND RNA ELEMENTS IN TOMBUSVIRUS REPLICATION." UKnowledge, 2011. http://uknowledge.uky.edu/plantpath_etds/1.

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Two thirds of plant viruses are positive-strand RNA viruses including the family Tombusviridae. One of the best-studied members of this family is Tomato bushy stunt virus (TBSV). Like many other viruses, TBSV has much fewer genes when compared to its hosts’ genome. Nevertheless, TBSV utilizes its genome very judiciously. To compensate for a lack of many proteins of its own, it codes for multi-functional replication protein p33 and also co-opts host factors to facilitate its replication. By using recombinant replication proteins p33 and p92 containing single amino acid changes in protein-protei

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31

Rytkönen, A. (Anna). "The role of human replicative DNA polymerases in DNA repair and replication." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514281381.

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Abstract The maintenance of integrity of the genome is essential for a cell. DNA repair and faithful DNA replication ensure the stability of the genome. DNA polymerases (pols) are the enzymes that synthesise DNA, a process important both in DNA replication and repair. In DNA replication DNA polymerases duplicate the genome during S phase prior to cell division. Pols α, δ, and ε are implicated in chromosomal DNA replication, but their exact function in replication is not yet completely clear. The mechanisms of different repair pathways and proteins involved are not yet completely characterised

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32

Pourahmad, Jaktaji Razieh. "Interplay between DNA replication and repair revealed by an RNA polymerase mutation." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272372.

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33

Leon, Ronald P. "Structural and functional analysis of MCM helicases in eukaryotic DNA replication /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biophysics & Genetics, Program in Molecular Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 90-98). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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34

Heller, Ryan C. "Mechanisms of replisome assembly and stalled fork reactivation at DNA replication blocks /." Access full-text from WCMC:, 2006. http://proquest.umi.com/pqdweb?did=1296086331&sid=9&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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35

Huo, Lin. "Identification and characterization of novel DNA replication-initiation proteins in budding yeast /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BICH%202006%20HUO.

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36

Kowalski, Magdalena Pauline. "Investigating the function of non-coding RNAs in chromosomal DNA replication." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708507.

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37

Wei, Ting. "Characterization of two tomato ringspot virus replication proteins : the NTB protein and the RNA-dependent RNA polymerase." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54840.

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Tomato ringspot virus (ToRSV) replicates in large protein complexes that are associated with modified endoplasmic reticulum membranes. The ToRSV RNA-dependent RNA polymerase (Pol) and integral membrane protein NTB-VPg are essential components of these complexes. Membrane-associated modifications of NTB-VPg (N-glycosylation and a putative signal peptidase cleavage) were previously observed in vitro but were not well characterized. Two forms of the polymerase were detected in infected plants: the full-length Pol, which accumulates at low concentration and the VPg-Pro-Pol' polyprotein, which incl

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38

Wang, Yisheng. "Characterizations of DNA replication proteins from herpes simplex virus type 1." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185295.

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This study was designed to characterize two DNA replication proteins from herpes simplex virus type 1 (HSV-1): the major DNA binding protein (ICP8) and the DNA polymerase. The two proteins are among the seven proteins required for viral DNA synthesis. Four areas were investigated. First, the ICP8 protein was purified from an overproducing cell and showed to behave the same as the viral protein in interacting with DNA. To define the DNA-binding domain of the protein, a proteolytic fragment with the same DNA-binding specificity as the intact protein was identified by a protein blotting assay. N-

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39

Dudderidge, Tim. "The role of DNA replication licensing proteins in urological cancer management." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654117.

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The non-invasive diagnosis of cancer and assessment of disease severity are both important challenges facing urologists managing patients with kidney, bladder and prostate cancer. Both challenges can potentially be met through the use of molecular markers of cancer that are present in blood, urine and biopsy material from tumours. In this thesis I explore the use of DNA replication licensing proteins, key components of the DNA replication machinery, as diagnostic, prognostic and predictive factors for urological cancers. The main markers studied, Mcm2, McmS and geminin are crucially important

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40

Yu, Zhiling. "Interactions and architecture of human MCM proteins in vitro and in vivo /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BICH%202003%20YU.

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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 118-137). Also available in electronic version. Access restricted to campus users.

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41

Beeharry, Yasnee. "Role of RNA Genome Structure and Paraspeckle Proteins In Hepatitis Delta Virus Replication." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35343.

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The Hepatitis Delta Virus (HDV) is an RNA pathogen that uses the host DNA-dependent RNA polymerase II (RNAP II) to replicate. Previous studies identified the right terminal domain of genomic polarity (R199G) of HDV RNA as an RNAP II promoter, but the features required for HDV RNA to be used as an RNA promoter were unknown. In order to identify the structural features of an HDV RNA promoter, I analyzed 473,139 sequences representing 2,351 new R199G variants generated by high-throughput sequencing of a viral population replicating in 293 cells. To complement this analysis, I also analyzed the sa

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42

Fletcher, Ryan James. "Structural and biochemical studies of mini-chromosomal maintenance proteins /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Biochemistry and Molecular Genetics) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 84-97). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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43

Johnson, Vinu. "Structural and Biophysical Studies of Single-Stranded DNA Binding Proteins and dnaB Helicases, Proteins Involved in DNA Replication and Repair." University of Toledo / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1198939056.

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44

Sayer, Penelope Jane. "Characterisation of Staphylococcus aureus GyrB and ParE proteins and their interactions with antibacterial agents." Thesis, St George's, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299382.

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45

Sommariva, Elena. "Role of fission yeast replication pausing and termination proteins in replication associated DNA damage checkpoint and repair." Thesis, St George's, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418176.

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46

Chan, Man Kid. "The interaction between Y box binding protein 1 and DNA replication proteins." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66802.

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A coordinated response to DNA damage is vital to maintain cellular viability and prevent the onset of disease. In mammalian cells, the intra-S phase checkpoint regulator, ATR (Ataxia-telangiectasia mutated and RAD3-related) kinase coordinates the response to DNA damage to ensure the genome is accurately and completely replicated before the cell enters mitosis. Y box Binding Protein 1 (YB-1), a transcription and translation factor, has previously been implicated in cell proliferation and the development of chemotherapeutic resistance. YB-1 has been linked to a wide variety of

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47

Liku, Muluye E. "CDK regulation of replication proteins: Mcm2-7 and DNA polymerase alpha primase." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3324598.

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48

Kommajosyula, Naveen. "Regulation of DNA Replication Origins in Fission Yeast: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/436.

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Cells need to complete DNA replication in a timely and error-free manner. To ensure that replication is completed efficiently and in a finite amount of time, cells regulate origin firing. To prevent any errors from being transmitted to the next generation, cells have the checkpoint mechanism. The S-phase DNA damage slows replication to allow the cell to repair the damage. The mechanism of replication slowing by the checkpoint was not clear in fission yeast, Schizosaccharomyces pombe, at the start of my thesis. The downstream targets of the DNA damage checkpoint in fission yeast were also uncle

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49

Sun, Wei-Hsin. "The induction of DNA replication in quiescent mammalian nuclei by Xenopus egg extracts." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314371.

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50

Senger, Anne. "A study of DNA replication and repair proteins from Bacteriophage T4 and a related phage /." See Full Text at OhioLINK ETD Center (Requires Adobe Acrobat Reader for viewing), 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1104776177.

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Thesis (M.S.)--University of Toledo, 2004.<br>Typescript. "A thesis [submitted] as partial fulfillment of the requirements of the Master of Science degree in Chemistry." Bibliography: leaves 111-112.

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