Academic literature on the topic 'Ro60'

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Journal articles on the topic "Ro60"

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Murng, Sai H. K., and Moira Thomas. "Clinical associations of the positive anti Ro52 without Ro60 autoantibodies: undifferentiated connective tissue diseases." Journal of Clinical Pathology 71, no. 1 (2017): 12–19. http://dx.doi.org/10.1136/jclinpath-2015-203587.

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AimsAutoantibodies targeting Ro52 and Ro60 antigens are historically reported as anti SSA/Ro. In general anti SSA/Ro results are either anti Ro52+Ro60+ or anti Ro52−Ro60+ antibodies. Anti Ro52 without anti Ro60 (Ro52+ Ro60−) antibodies are often not reported routinely. This study intends to review the potential significance of these autoantibodies in the management of connective tissue diseases.MethodA retrospective survey of Ro52+Ro60− was carried out as part of the service evaluation of extractable nuclear antigen antibodies (ENA) reporting from the immunology laboratory, the NHS Greater Gla
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Prieto-Peña, D., B. Atienza-Mateo, M. A. González-Gay, R. Blanco, and M. Lopez-Hoyos. "POS1346 CLINICAL ASSOCIATIONS OF ANTI-RO52 ANTIBODIES IN PATIENTS WITH SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 955.2–955. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1729.

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Background:Anti-SSA/Ro antibodies (Abs) can target Ro60 and Ro52 antigens. The presence of anti-Ro60 Abs has been widely described in patients with systemic autoimmune rheumatic diseases (SARDs). However, the clinical implication of anti-Ro52 Abs for the diagnosis and management of SARDs remains unclear.Objectives:To assess the clinical associations of anti-Ro52 antibodies in patients with high clinical suspicion of SARDs.Methods:We retrieved the clinical records of all patients with positive anti-Ro52 Abs tested in our hospital between November 2017 and September 2020. Patients were divided i
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Sim, Soyeong, Kevin Hughes, Xinguo Chen, and Sandra L. Wolin. "The Bacterial Ro60 Protein and Its Noncoding Y RNA Regulators." Annual Review of Microbiology 74, no. 1 (2020): 387–407. http://dx.doi.org/10.1146/annurev-micro-020620-062812.

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Ro60 ribonucleoproteins (RNPs), composed of the ring-shaped Ro 60-kDa (Ro60) protein and noncoding RNAs called Y RNAs, are present in all three domains of life. Ro60 was first described as an autoantigen in patients with rheumatic disease, and Ro60 orthologs have been identified in 3% to 5% of bacterial genomes, spanning the majority of phyla. Their functions have been characterized primarily in Deinococcus radiodurans, the first sequenced bacterium with a recognizable ortholog. In D. radiodurans, the Ro60 ortholog enhances the ability of 3′-to-5′ exoribonucleases to degrade structured RNA dur
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Leng, Yuanyuan, Soyeong Sim, Valentin Magidson, and Sandra L. Wolin. "Noncoding Y RNAs regulate the levels, subcellular distribution and protein interactions of their Ro60 autoantigen partner." Nucleic Acids Research 48, no. 12 (2020): 6919–30. http://dx.doi.org/10.1093/nar/gkaa414.

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Abstract Noncoding Y RNAs are abundant in animal cells and present in many bacteria. These RNAs are bound and stabilized by Ro60, a ring-shaped protein that is a target of autoantibodies in patients with systemic lupus erythematosus. Studies in bacteria revealed that Y RNA tethers Ro60 to a ring-shaped exoribonuclease, forming a double-ringed RNP machine specialized for structured RNA degradation. In addition to functioning as a tether, the bacterial RNA gates access of substrates to the Ro60 cavity. To identify roles for Y RNAs in mammals, we used CRISPR to generate mouse embryonic stem cells
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Greiling, T., C. Dehner, X. Chen, et al. "068 Lupus Ro60 autoantigen cross-reactivity with commensal Ro60 orthologs." Journal of Investigative Dermatology 137, no. 5 (2017): S12. http://dx.doi.org/10.1016/j.jid.2017.02.081.

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Deshmukh, Umesh S., Janet E. Lewis, Felicia Gaskin, et al. "Immune Responses to Ro60 and Its Peptides in Mice. I. The Nature of the Immunogen and Endogenous Autoantigen Determine the Specificities of the Induced Autoantibodies." Journal of Experimental Medicine 189, no. 3 (1999): 531–40. http://dx.doi.org/10.1084/jem.189.3.531.

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Anti-Ro60 autoantibodies are found in a variety of autoimmune disorders including systemic lupus erythematosus (SLE), Sjögren's syndrome, primary biliary cirrhosis, and active hepatitis. They are the most prevalent autoantibodies in normal individuals and in asymptomatic mothers of infants afflicted with neonatal lupus. In the present study, immune responses to recombinant human Ro60 (rhRo60) and recombinant mouse Ro60 (rmRo60) and selected Ro60 peptides in non–SLE-prone mice were investigated. Multiple T and B cell epitopes were identified in Ro60. Immunizations with either xenogeneic or auto
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Labbé, Jean-Claude, Siegfried Hekimi, and Luis A. Rokeach. "Assessing the function of the Ro ribonucleoprotein complex using Caenorhabditis elegans as a biological tool." Biochemistry and Cell Biology 77, no. 4 (1999): 349–54. http://dx.doi.org/10.1139/o99-036.

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The Ro ribonucleoprotein complex (Ro RNP) was initially described as an autoimmune target in human diseases such as systemic lupus erythematosus and Sjögren's syndrome. In Xenopus and human cells, its general structure is composed of one major protein of 60 kDa, Ro60, that binds to one of four small RNA molecules, designated Y RNAs. Although no function has been assigned to the Ro RNP, Ro60 has been shown to bind mutant 5S ribosomal RNA (rRNA) molecules in Xenopus oocytes, suggesting a role for Ro60 in 5S rRNA biogenesis. Ro60 has also been shown to participate in the regulation of the transla
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Menéndez, Aurora, Jesús Gómez, Luis Caminal-Montero, José Bernardino Díaz-López, Iván Cabezas-Rodríguez, and Lourdes Mozo. "Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus." Scientific World Journal 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/832789.

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Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P=0.024andP=0.019, resp.) and anti-Ro52/TRIM21 (P=0.026andP=0.022, resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P=0.014) tha
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Infantino, M., C. Bentow, A. Seaman, et al. "Highlights on Novel Technologies for the Detection of Antibodies to Ro60, Ro52, and SS-B." Clinical and Developmental Immunology 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/978202.

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Objective. We aimed to compare a chemiluminescent immunoassay (CIA, QUANTA Flash) on BIO-FLASH with a multiplex flow immunoassay (MFI) on BioPlex 2200 for the detection of antibodies to Ro60, Ro52, and SS-B.Methods. The study included 241 samples, from patients suffering from systemic autoimmune diseases (n=108) as well as disease controls (n=133). All samples were tested for anti-Ro52, anti-Ro60, and anti-SS-B (La) antibodies on QUANTA Flash (INOVA Diagnostics, San Diego, USA) and BioPlex 2200 (Bio-Rad Laboratories Inc., Hercules, USA). Discrepant samples were tested by two independent method
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Garcia, Eric L., Adewunmi Onafuwa-Nuga, Soyeong Sim, Steven R. King, Sandra L. Wolin, and Alice Telesnitsky. "Packaging of Host mY RNAs by Murine Leukemia Virus May Occur Early in Y RNA Biogenesis." Journal of Virology 83, no. 23 (2009): 12526–34. http://dx.doi.org/10.1128/jvi.01219-09.

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ABSTRACT Moloney murine leukemia virus (MLV) selectively encapsidates host mY1 and mY3 RNAs. These noncoding RNA polymerase III transcripts are normally complexed with the Ro60 and La proteins, which are autoantigens associated with rheumatic disease that function in RNA biogenesis and quality control. Here, MLV replication and mY RNA packaging were analyzed using Ro60 knockout embryonic fibroblasts, which contain only ∼3% as much mY RNA as wild-type cells. Virus spread at the same rate in wild-type and Ro knockout cells. Surprisingly, MLV virions shed by Ro60 knockout cells continued to packa
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Dissertations / Theses on the topic "Ro60"

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Fazio, Sofia. "Rôle du complexe Ro60/RNYs dans les macrophages chargés des lipides." Electronic Thesis or Diss., Université Côte d'Azur, 2020. http://theses.univ-cotedazur.fr/2020COAZ6041.

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Ro60, protéine de liaison à l'ARN qui s'associe aux YRNAs pour former le complexe RoRNP, est une cible de la réponse immunitaire chez les patients atteints de lupus érythémateux disséminé (LED) et du syndrome de Sjögren (SS). Les autoanticorps anti-Ro60 dans le patients SLE et SS peuvent pénétrer à l'intérieur des cellules et se localiser dans le noyau. Les souris Ro60-/- développent un syndrome auto-immun et un statut pro-inflammatoire avec des caractéristiques de LED, indiquant l’implication de Ro60 dans la pathogenèse de cette maladie. D’autre part, les patients atteints de LED et de SS meu
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Waller, Helen Louise. "UV-induced reactive oxygen species production and altered cellular response to the Ro60 autoantigen." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29490.

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The primary aim of this project was to investigate if T cells isolated from systemic lupus erythematosus subjects were able to respond to purified human recombinant Ro60 after it has been modified by reactive oxygen species. Initial work focused on purification of soluble recombinant Ro60 after overexpression in E. coli. Ro60 was then exposed to reactive oxygen species via ultraviolet B irradiation and metal catalyzed oxidation and immunochemical techniques were applied to detect aggregation, fragmentation and carbonyl formation as markers of protein oxidation. None of these markers were induc
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Lamontagne, Anne-Marie. "Étude du mécanisme de rétrotransposition des ARN hY dans les cellules humaines." Mémoire, Université de Sherbrooke, 2011. http://hdl.handle.net/11143/5556.

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Chez l'humain, il y a présence de quatre petits ARN Y; soit les ARN hYl, hY3, hY4 et hY5. La longueur de ces ARN varie entre 84 (hY5) à 112 (hY1) nucléotides. Ces ARN forment une longue structure tige boucle pouvant être liée par une protéine nommée Ro60. Les ribonucléoprotéines Ro (Ro RNP) résultent de la liaison de Ro60 ainsi que celle de la protéine La aux ARN hY. Ces Ro RNP sont la cible d'auto-anticorps chez des patients atteints de pathologies du tissu conjonctif, comme le lupus érythémateux systémique. Les connaissances sur le rôle de ces petits ARN non-codants sont limitées. Cela rend
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Azevedo, Neto Joaquim Gon?alves de. "Efeito do agonista do receptor da nociceptina/orfanina FQ, Ro65-6570, no comportamento do tipo ansioso de camundongos desamparados." PROGRAMA DE P?S-GRADUA??O EM PSICOBIOLOGIA, 2017. https://repositorio.ufrn.br/jspui/handle/123456789/24443.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-12-04T20:41:48Z No. of bitstreams: 1 JoaquimGoncalvesDeAzevedoNeto_DISSERT.pdf: 1209476 bytes, checksum: b176b29c8fe26fd7b3e020bb5279ef38 (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-12-07T19:42:32Z (GMT) No. of bitstreams: 1 JoaquimGoncalvesDeAzevedoNeto_DISSERT.pdf: 1209476 bytes, checksum: b176b29c8fe26fd7b3e020bb5279ef38 (MD5)<br>Made available in DSpace on 2017-12-07T19:42:32Z (GMT). No. of bitstreams: 1 JoaquimGoncalvesDeAzevedoNeto_DISSERT.pdf: 1209476 bytes,
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Simões, Pedro César Dinis. "Análise da correlação entre resultados experimentais e numéricos de NVH em bombas de óleo." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/21168.

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Mestrado em Engenharia Mecânica<br>O presente trabalho aborda o problema do NVH (Noise Vibration and Harshness) em bombas de óleo. Neste âmbito, é realizada numa fase inicial uma descrição das bombas de óleo quanto à sua constituição e princípio de funcionamento, sendo que a bomba utilizada neste trabalho é uma bomba de palhetas de cilindrada variável. A utilização destas bombas acarreta a vantagem de permitir uma melhor eficiência do motor do veículo, logo a tendência para as utilizar e estudar é cada vez maior. Assim, estre trabalho teve como objetivo perceber a correlação existente entre os
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Books on the topic "Ro60"

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Clarke, R. M. NSU Ro80 Road Test. Brooklands Books, 1999.

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Geological Survey (U.S.), ed. High-Resolution Marine Geologic Maps Showing Sediment Distribution On The Insular Shelf Off Luquillo, Puerto Rico, U.S. Geological Survey Open-File Report 98-204, 1999, (CD-ROM0. s.n., 1999.

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Book chapters on the topic "Ro60"

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Kurien, Biji T., and Michael P. Bachmann. "On-Membrane Renaturation of Recombinant Ro60 Autoantigen by Calcium Ions." In Methods in Molecular Biology. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2718-0_26.

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"Anti-Ro60." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_300166.

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"Ro60-Antikörper." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_313303.

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"Anti-Ro60-Antikörper." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_300167.

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Ambrosi, Aurélie, Albin Björk, and Marie Wahren-Herlenius. "Autoantibodies and autoantigens in Sjögren’s syndrome." In Oxford Textbook of Sjögren's Syndrome, edited by Elizabeth J. Price and Anwar R. Tappuni. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198806684.003.0005.

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Autoantibodies are a key serological feature of Sjögren’s syndrome (SS). The presence of Ro/Sjögren’s syndrome-related antigen A (SSA) autoantibodies is one of the items with the highest weight in the 2016 joint ACR/EULAR SS classification criteria. Autoantibodies appear before overt clinical disease manifestations, and patient autoantibody profiles seem stable over time, even after B-cell depleting therapy. Expression of Ro/SSA and La/Sjögren’s syndrome-related antigen B (SSB), the major autoantigens in SS, in the target organs (exocrine glands), local autoantibody production, and the capacity of autoantigen-containing immune complexes to induce interferon production all point to a central involvement of autoantibodies in disease pathogenesis. Here, we review the main autoantibody specificities reported in SS, their clinical associations, the current understanding of how autoantibody production is initiated and maintained, and how autoantibodies may exert pathogenic effects. We provide a comprehensive overview of the nature and biological function of the three main autoantigens, Ro52, Ro60, and La (Ro/SSA and La/SSB) found in SS.
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Conference papers on the topic "Ro60"

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Heredia, S., M. Martinez-Morillo, A. Riveros, et al. "AB0529 Role of the ANTI-RO52 and RO60 antibodies quantification in patients with systemic lupus erythematosus." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.5057.

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Gkoutzourelas, A., C. Liaskos, V. Papadopoulos, et al. "AB1181 Anti-ro60 seropositivity determines epitope specificity of anti-ro52 antibodies in patients with autoimmune rheumatic and malignant diseases." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.6760.

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Garcia, E. Grau, I. Chalmeta Verdejo, E. Sánchez Labrador, et al. "SAT0279 ANTI-RO52 KDA and ANTI-RO60 KDA analysis in systemic lupus erythematous patients to detect ANTI-RO false-negatives." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.5758.

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Grau, E., I. Chalmeta Verdejo, E. Labrador Sanchez, et al. "PS1:8 Anti-ro false-negatives detection through anti-ro52 kda and anti-ro60 kda analysis in systemic lupus erythematous patients." In 11th European Lupus Meeting, Düsseldorf, Germany, 21–24 March 2018, Abstract presentations. Lupus Foundation of America, 2018. http://dx.doi.org/10.1136/lupus-2018-abstract.57.

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Armagan, Berkan, Susan Robinson, Adriana Bazoberry, Thomas Grader-Beck, and Alan Baer. "SAT0172 ANTIBODIES TO BOTH RO52 AND RO60 DEFINE A SUBSET OF SJÖGREN’S MOST SUITABLE FOR CLINICAL TRIALS OF AGENTS TARGETING LYMPHOPROLIFERATIONS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.3387.

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Radziszewska, A., K. Webb, H. Peckham, and Y. Ioannou. "THU0484 Ro60 expression decreases with age in peripheral blood mononuclear cells of children and adolescents and correlates with tlr7 stimulation in pdcs of prepubertal children." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.5073.

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Da Silva, Victoria Caroline, and Mariana Calheiros Poloni. "INFERÊNCIAS DA IMUNOPATOLOGIA CONGÊNITA NAS MANIFESTAÇÕES CARDÍACAS DO LÚPUS ERITEMATOSO NEONATAL." In I Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1007.

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INTRODUÇÃO: O lúpus eritematoso neonatal (LEN), é uma patologia imunológica caracterizada pela presença de anticorpos maternos IgG específicos anti-Ro e anti-La capazes de atravessar a barreira placentária, culminando em lesões nos neonatos. As manifestações cardíacas serão abordadas nesse resumo, mas além desta, existem as manifestações hematológicas, hepáticas, cutâneas e neurológicas. OBJETIVOS: realizar revisão bibliográfica acerca da imunopatologia transplacentária em neonatos e suas consequentes manifestações clínicas no âmbito da cardiologia. MATERIAL E MÉTODOS: Revisão integrativa nas
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Tang, Meng, Yuanjiang Pei, Yu Zhang, Michael Traver, and Jeffrey Naber. "Effect of Fuel Chemical and Physical Properties on Spray and Ignition Characteristics Under Heavy-Duty Diesel Engine Conditions." In ASME 2019 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/icef2019-7266.

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Abstract Spray combustion in compression ignition (CI) engines is a complex physical-chemical phenomenon. The differences in key fuel properties between gasoline range fuels and diesel, including the distillation temperature ranges and fuel reactivity, affect spray formation and combustion. To understand the impact of these fuel effects, this study aims at a thorough computational investigation involving variations in both the fuel physical and chemical properties. Physical properties include latent heat of vaporization, specific heat capacity, density, vapor pressure, viscosity, and surface t
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