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Journal articles on the topic 'Roblox'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Meier, Cecile, Jose Luis Saorín, Alejandro Bonnet de León, and Alberto Guerrero Cobos. "Using the Roblox Video Game Engine for Creating Virtual tours and Learning about the Sculptural Heritage." International Journal of Emerging Technologies in Learning (iJET) 15, no. 20 (October 19, 2020): 268. http://dx.doi.org/10.3991/ijet.v15i20.16535.

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This paper describes an experience to incorporate the realization of virtual routes about the sculptural heritage of a city in the classroom by developing a simulation of the urban environment using a video game engine. Video game engines not only allow the creation of video games but also the creation and navigation of in-teractive three-dimensional worlds. For this research, Roblox Studio has been used, a simple and intuitive program in which no previous programming skills are required. During the 2018/2019 academic year, a pilot experience was carried out with 53 secondary school students who were given the task of designing a virtual environment in which they had to include 3D models of the sculptural her-itage of the city of Santa Cruz de Tenerife. Before starting the experience, the par-ticipants answered a questionnaire to obtain a previous idea of the students' knowledge about the creation of video games. Once the activity was finished and in order to evaluate the result of the activity, the participants answered a final questionnaire. The students emphasized that after the activity they are more aware of the sculptural heritage of Santa Cruz and that they consider themselves capable of creating their own interactive worlds with Roblox.

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Jeon, Joon Hyun. "A study on the Principle of Metaverse Composition with a focus on Roblox." Korean Association for Visual Culture 38 (June 30, 2021): 257–79. http://dx.doi.org/10.21299/jovc.2021.38.10.

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3

Siqueira, Beatriz. "O ensino de Geografia física e os jogos digitais." Terrae Didatica 15 (July 11, 2019): e019022. http://dx.doi.org/10.20396/td.v15i0.8653224.

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O presente trabalho tem como finalidade o desenvolvimento de uma prática de ensino-aprendizagem no Ensino Básico, por meio de jogo digital e aplicada ao estudo do meio natural. O tema selecionado foi a observação do tempo atmosférico, conteúdo do 6° ano dos anos finais do Ensino Fundamental e a dinâmica natural do planeta Terra, conteúdo do 8° ano dos anos finais do Ensino Fundamental, ambos expressos na Matriz de Avaliação Processual de Geografia, da rede pública do Estado de São Paulo. O jogo Roblox, familiar entre os alunos, teve uma de suas plataformas, denominada Natural Disaster Survival, selecionada para o desenvolvimento da aula prática e trouxe à tona a necessidade de ressignificar o uso dos dispositivos eletrônicos no espaço escolar.

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Dickinson, Rachel E., Lynn Hryhorskyj, Hannah Tremewan, Kirsten Hogg, Axel A. Thomson, Alan S. McNeilly, and W. Colin Duncan. "Involvement of the SLIT/ROBO pathway in follicle development in the fetal ovary." REPRODUCTION 139, no. 2 (February 2010): 395–407. http://dx.doi.org/10.1530/rep-09-0182.

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In humans and domestic mammals, pivotal processes in ovary development, including primordial follicle assembly, occur prenatally. These events are essential for determining fertility in adult life; however, they remain poorly understood at the mechanistic level. In mammals, the SLITs (SLIT1, SLIT2 and SLIT3) and their ROBO (ROBO1, ROBO2, ROBO3/RIG-1 and ROBO4/MAGIC ROBO) receptors regulate neural, leukocyte, vascular smooth muscle cell and endothelial cell migration. In addition, the SLIT/ROBO pathway has functional roles in embryonic development and in the adult ovary by inhibiting cell migration and promoting apoptosis. We therefore characterised follicle formation and investigated the expression and localisation of the ROBO/SLIT pathway in the ovine fetal ovary. Using RT-PCR, we identifiedSLIT2,SLIT3,ROBO1,ROBO2andROBO4in sheep ovaries harvested across gestation. The real-time quantitative PCR results implied thatROBO2expression andROBO4expression were elevated during the early stages of follicle formation and stayed abundant during primordial follicle maturation (P<0.05). Immunohistochemistry examination demonstrated that ROBO1 was localised to the pre-granulosa cells, while ROBO2, ROBO4 and SLIT2 were expressed in the oocytes of the developing primordial follicle. This indicates that in the fetal ovary, SLIT–ROBO signalling may require an autocrine and paracrine interaction. Furthermore, at the time of increased SLIT–ROBO expression, there was a significant reduction in the number of proliferating oocytes in the developing ovary (P<0.0001). Overall, these results suggest, for the first time, that the SLIT–ROBO pathway is expressed at the time of follicle formation during fetal ovary development.

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Dickinson, Rachel E., Michelle Myers, and W. Colin Duncan. "Novel Regulated Expression of the SLIT/ROBO Pathway in the Ovary: Possible Role during Luteolysis in Women." Endocrinology 149, no. 10 (June 19, 2008): 5024–34. http://dx.doi.org/10.1210/en.2008-0204.

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The human corpus luteum (CL) undergoes luteolysis, associated with marked tissue and vascular remodeling, unless conception occurs and the gland is rescued by human chorionic gonadotropin (hCG). In Drosophila the Slit gene product, a secreted glycoprotein, acts as a ligand for the roundabout (robo) transmembrane receptor. Together they influence the guidance and migration of neuronal and nonneuronal cells. In vertebrates three Slit (Slit1, Slit2, Slit3) and four Robo (Robo1, Robo2, Robo3/Rig-1, Robo4/Magic Robo) genes have been identified. ROBO1, SLIT2, and SLIT3 are also inactivated in human cancers and may regulate apoptosis and metastasis. Because processes such as apoptosis and tissue remodeling occur during the regression of the CL, the aim of this study was to investigate the expression, regulation, and effects of the SLIT and ROBO genes in human luteal cells. Immunohistochemistry and RT-PCR revealed that SLIT2, SLIT3, ROBO1, and ROBO2 are expressed in luteal steroidogenic cells and fibroblast-like cells of the human CL. Furthermore, using real-time quantitative PCR, expression of SLIT2, SLIT3, and ROBO2 was maximal in the late-luteal phase and significantly reduced after luteal rescue in vivo with exogenous hCG (P < 0.05). Additionally, hCG significantly inhibited SLIT2, SLIT3, and ROBO2 expression in cultured luteinized granulosa cells (P < 0.05). Blocking SLIT-ROBO activity increased migration and significantly decreased levels of apoptosis in primary cultures of luteal cells (P < 0.05). Overall, these results suggest the SLIT/ROBO pathway could play an important role in luteolysis in women.

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6

Jiang, Zhengdong, Gang Liang, Ying Xiao, Tao Qin, Xin Chen, Erxi Wu, Qingyong Ma, and Zheng Wang. "Targeting the SLIT/ROBO pathway in tumor progression: molecular mechanisms and therapeutic perspectives." Therapeutic Advances in Medical Oncology 11 (January 2019): 175883591985523. http://dx.doi.org/10.1177/1758835919855238.

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The SLITs (SLIT1, SLIT2, and SLIT3) are a family of secreted proteins that mediate positional interactions between cells and their environment during development by signaling through ROBO receptors (ROBO1, ROBO2, ROBO3, and ROBO4). The SLIT/ROBO signaling pathway has been shown to participate in axonal repulsion, axon guidance, and neuronal migration in the nervous system and the formation of the vascular system. However, the role of the SLIT/ROBO pathway has not been thoroughly clarified in tumor development. The SLIT/ROBO pathway can produce both beneficial and detrimental effects in the growth of malignant cells. It has been confirmed that SLIT/ROBO play contradictory roles in tumorigenesis. Here, we discuss the tumor promotion and tumor suppression roles of the SLIT/ROBO pathway in tumor growth, angiogenesis, migration, and the tumor microenvironment. Understanding these roles will help us develop more effective cancer therapies.

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7

Golos, Aleksandra, Dorota Jesionek-Kupnicka, Tadeusz Robak, Ewa Wawrzyniak, Lidia Anna Gil, Mieczyslaw Komarnicki, Anna Wache, and Agnieszka Wierzbowska. "The Role of the Slit-Robo Family in Adult Patients with Acute Myeloid Leukemia." Blood 126, no. 23 (December 3, 2015): 3816. http://dx.doi.org/10.1182/blood.v126.23.3816.3816.

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Abstract Introduction: SLIT-ROBO is newly discovered ligand-receptor family of neuronal guidance molecules. Recently, it has been proved that these proteins are involved in both, physiologic and pathologic angiogenesis. In animal models, it was shown both, pro-and antiangiogenic of SLIT-ROBO signaling. Moreover, the interaction of SLIT ligands with their roundabout receptors (ROBO) results in promotion of apoptosis, adhesion and blocking of cell cycle. There is evidence that SLIT-ROBO proteins are involved in pathogenesis of solid tumors, both in angiogenesis dependent and independent way. The role of SLIT-ROBO proteins in biology of acute myeloid leukemia (AML) remains unknown.The only two hitherto published studies considering ROBO4 expression in AML have revealed its increased expression in the blasts cells. The aim of the study was to evaluate the role of SLIT-ROBO proteins in AML. The expression of SLIT ligands, and their receptors ROBO was assessed in bone marrow of newly diagnosed AML patients and in the control group. The expression level of the proteins was correlated with known prognostic factors, response to treatment and overall survival (OS), as well as angiogenesis activity. To our knowledge, it has been the first study investigating the whole family of SLIT-ROBO proteins in AML. Methods: Expression SLIT-ROBO proteins was assessed in bone marrow biopsy specimens of 79 newly diagnosed AML patients with median age 59 years [18-87]. The paraffin-embedded tissue blocks were retrieved and subjected to immunohistochemistry for SLIT ligands (SLIT1, SLIT2, SLIT3), and their receptors ROBO1, ROBO2, ROBO3, and ROBO4. The positive blasts cells were semi-quantitatively analyzed according to previously published methods (Perrone et al, 2006). For the purpose of analysis the patients were divided into "low-expressers" and "high-expressers". Concurrently, all samples were immunostained for CD34 to calculate microvessel density (MVD) as an equivalent of angiogenesis. The control group was composed of 23 BM biopsies form patients with newly diagnosed lymphoma without bone marrow involvement. Results: Expression of ROBO receptors and SLIT ligands in AML patients and in the control group. In our study higher expression of ROBO1, ROBO2, and ROBO3 was observed more often in AML patients compared to the control group (p<0.0001, p<0.001, and p=0.09, respectively, Fig 1.). In contrast, low expression of SLIT1, SLIT2, and SLIT3 ligands has been shown more often in AML than in control BM samples (p<0.0001, p=0.003, and p=0.001, respectively,Fig.2.). Higher expression of ROBO1, ROBO2, and ROBO3 was more often in AML patients ≥60 years (p=0.04, p=0.008, and p=0.02, respectively).Conversely, low expression of ROBO4 was more often observed in elderly AML (p=0.06). The majority of patients with de novo AML had low expression of SLIT1 and SLIT2 (p=0.053 and p=0.055, respectively). As to ROBO, higher expression of ROBO2 in the group with secondary AML was more frequent (p=0.09). No significant correlations between the SLIT-ROBO proteins' expression,neither cytogenetic risk group nor clinical stage parameters such as WBC, hemoglobin level, proportion of leukemic blasts in BM, or LDH activity were found. Similarly, neither of the SLIT-ROBO proteins influenced the complete remission rate (CR) and overall survival (OS). Relationship between SLIT-ROBO expression and angiogenesis activity in AML patients and control group. Significantly higher MVD in BM of AML patients than in control group (Me 51 [9-140] vs 16 [4-78], p<0.0001) has been observed. ROBO4was the only protein that expression correlated significantly with MVD. Higher expression of ROBO4 was associated with higher MVD in both, AML and the control group (p=0.05 and p=0.01, respectively). Conclusions: SLIT-ROBO family members play a role in biology of AML. ROBO4 is involved in both, physiologic and pathologic angiogenesis A better understanding of SLIT-ROBO signaling pathway in leukemic blasts may create new optionsfor AML therapy. Acknowledgments: AG and DJ-K both equally contributed to the study. This work was supported by grants from Medical University of Lodz, Lodz, Poland (502-03/1-093-01/502-14-077 and 503/1-093-01/503-11-001). Disclosures Robak: Eisai Inc: Research Funding. Wierzbowska:Janssen, Celgene: Consultancy.

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Du, Yao, Thomas D. Grace, Krithika Jagannath, and Katie Salen-Tekinbas. "Connected Play in Virtual Worlds: Communication and Control Mechanisms in Virtual Worlds for Children and Adolescents." Multimodal Technologies and Interaction 5, no. 5 (May 11, 2021): 27. http://dx.doi.org/10.3390/mti5050027.

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Technology plays an essential role in shaping youth’s communication and social interactions in online multiplayer games. Due to physical distancing restrictions during the COVID-19 global pandemic, online multiplayer games like Minecraft and Roblox are well-positioned to amplify healthy communication/social connections and mitigate the impact of social isolation. Research so far has been focused on how these gaming environments support youth development from the perspectives of individual stakeholders (e.g., caregivers, educators, designers, and developers). However, features of these games, such as communication and parental controls, are often misaligned with the ways in which children develop communication and social skills. Using a series of case studies of popular virtual worlds and online games, this paper provides an analysis of critical design features that serve youth throughout different stages of childhood and early adolescence. We offer three main contributions: (a) a comparison matrix of similarities and differences in communication and control features between platforms; (b) an evaluation of design features in selected virtual world platforms that promote safe and positive social interactions; and (c) a method for cross-platform comparison aimed at helping researchers, designers, and practitioners examine specific dimensions of social communication and play experience in virtual worlds.

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9

Yadav, Suresh Singh, and Gopeshwar Narayan. "Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/683025.

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Transmembrane roundabout receptor family members (ROBO1–ROBO4) principally orchestrate the neuronal guidance mechanism of the nervous system. Secreted glycoprotein SLITs are the most appreciated ligands for ROBOs. Recently identified ROBO4 is the key mediator of SLIT-ROBO mediated developmental and pathological angiogenesis. Although SLIT2 has been shown to interact with ROBO4 as ligand, it remains an open question whether this protein is the physiologic partner of ROBO4. The purpose of this review is to summarise how reliable SLIT2 as ligand for ROBO4 is, if not what the other possible mechanisms demonstrated till date for ROBO4 mediated developmental and pathological angiogenesis are. We conclude that ROBO4 is expressed specially in vascular endothelial cells and maintains the vascular integrity via either SLIT2 dependent or SLIT2 independent manner. On the contrary, it promotes the pathological angiogenesis by involving different signalling arm(s)/unknown ligand(s). This review explores the interactions SLIT2/ROBO1, SLIT2/ROBO1–ROBO4, ROBO1/ROBO4, and ROBO4/UNC5B which can be promising and potential therapeutic targets for developmental angiogenesis defects and pathological angiogenesis. Finally we have reviewed the ROBO4 signalling pathways and made an effort to elaborate the insight of this signalling as therapeutic target of pathological angiogenesis.

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Kim, Minkyung, Andrew P. Roesener, Philipe R. F. Mendonca, and Grant S. Mastick. "Robo1 and Robo2 have distinct roles in pioneer longitudinal axon guidance." Developmental Biology 358, no. 1 (October 2011): 181–88. http://dx.doi.org/10.1016/j.ydbio.2011.07.025.

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11

Fouquet, C., T. Di Meglio, L. Ma, T. Kawasaki, H. Long, T. Hirata, M. Tessier-Lavigne, A. Chedotal, and K. T. Nguyen-Ba-Charvet. "Robo1 and Robo2 Control the Development of the Lateral Olfactory Tract." Journal of Neuroscience 27, no. 11 (March 14, 2007): 3037–45. http://dx.doi.org/10.1523/jneurosci.0172-07.2007.

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12

Rama, Nicolas, Alexandre Dubrac, Thomas Mathivet, Róisín-Ana Ní Chárthaigh, Gael Genet, Brunella Cristofaro, Laurence Pibouin-Fragner, Le Ma, Anne Eichmann, and Alain Chédotal. "Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization." Nature Medicine 21, no. 5 (April 20, 2015): 483–91. http://dx.doi.org/10.1038/nm.3849.

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13

Hivert, B. "Robo1 and Robo2 Are Homophilic Binding Molecules That Promote Axonal Growth." Molecular and Cellular Neuroscience 21, no. 4 (December 2002): 534–45. http://dx.doi.org/10.1006/mcne.2002.1193.

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KINRADE, EDWARD F. V., and ALICIA HIDALGO. "Lateral neuron–glia interactions steer the response of axons to the Robo code." Neuron Glia Biology 1, no. 2 (May 2004): 101–12. http://dx.doi.org/10.1017/s1740925x04000225.

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Glia are required for axon pathfinding along longitudinal trajectories, but it is unknown how this relates to the molecular paradigm of axon guidance across the midline. Most interneuron axons in bilateral organisms cross the midline only once. Preventing them from recrossing the midline requires the expression of Robo receptors on the axons. These sense the repulsive signal Slit, which is produced by the midline. The lateral positioning of longitudinal axons depends on the response to Slit by the combination of Robo receptors expressed by the axons, on selective fasciculation, and on longitudinal (lateral) glia. Here, we analyse how longitudinal glia influence reading of the ‘Robo code’ by axons. We show that whereas loss of robo1 alone only affects the most medial axons, loss of both glial cells missing (gcm) and robo1 causes a severe midline collapse of longitudinal axons, similar to that caused by the loss of multiple Robo receptors. Furthermore, whereas ectopic expression of robo2 is sufficient to displace the medial MP2 axons along a more lateral trajectory, this does not occur in gcm–robo1 double-mutant embryos, where axons either do not extend at all or they misroute exiting the CNS. Hence, lateral neuron–glia interactions steer the response of axons to the Robo code.

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Jaworski, A., H. Long, and M. Tessier-Lavigne. "Collaborative and Specialized Functions of Robo1 and Robo2 in Spinal Commissural Axon Guidance." Journal of Neuroscience 30, no. 28 (July 14, 2010): 9445–53. http://dx.doi.org/10.1523/jneurosci.6290-09.2010.

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Sundaresan, Vasi, Elvira Mambetisaeva, William Andrews, Adelaide Annan, Bernd Knöll, Guy Tear, and Lawrence Bannister. "Dynamic expression patterns of Robo (Robo1 and Robo2) in the developing murine central nervous system." Journal of Comparative Neurology 468, no. 4 (December 12, 2003): 467–81. http://dx.doi.org/10.1002/cne.10984.

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Shibata, Fumi, Yuko Goto-Koshino, Miyuki Ito, Yumi Fukuchi, Yoshihiro Morikawa, Hiromichi Matsushita, Hayato Miyachi, Toshio Kitamura, and Hideaki Nakajima. "Robo4/Magic Roundabout Is a Novel Surface Marker for Murine and Human Hematopoietic Stem Cells." Blood 108, no. 11 (November 16, 2006): 682. http://dx.doi.org/10.1182/blood.v108.11.682.682.

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Abstract A variety of cell surface markers such as c-Kit, Sca-1, CD34 and Flt-3 have been utilized to prospectively isolate murine or human hematopoietic stem cells (HSCs). While murine HSCs were shown to be highly enriched in CD34−c-Kit+Sca-1+Lineage- (CD34−KSL) fraction, this population is still not homogeneous for long-term HSCs. In human, CD34+ cells are regarded as crude HSC fraction and used for clinical applications. However, quiescent human HSCs are also found in CD34− fraction, indicating that CD34 is not a bona fide marker for human HSC. Thus, novel surface markers that can be used to purify human or murine HSCs to homogeneity need to be identified. Roundabout (Robo) family proteins are immunoglobulin-type cell surface receptors that are predominantly expressed in nervous system. Slit2, a ligand for Robo, is a large leucine-rich repeat-containing secreted protein that is also expressed in brain. By binding with Robo, Slit2 acts as a repellant for axon guidance of developing neurons and they are critical for correct wiring of neuronal network. Robo family comprises four family members, Robo1 – Robo4, and Robo4 is distinct in that it is expressed specifically in endothelial cells, but not in brain. In this study, we investigated Robo4 for its possible application for HSC identification in murine and human hematopoietic system. By RT-PCR, Robo4 was specifically expressed in murine KSL fraction, and was not expressed in lineage positive cells and various progenitors such as common myeloid progenitor (CMP), granulocyte-monocyte progenitor (GMP), megakaryocyte/erythroid progenitor (MEP) and common lymphoid progenitor (CLP). Moreover, the expression of Robo4 was highest in side population of KSL cells (KSL-SP), and moderate in KSL-main population (KSL-MP) cells. Monoclonal antibody raised against Robo4 identified its high expression in KSL cells by FACS. FACS analysis of human cord blood cells revealed that Robo4 is highly expressed in CD34+ cells, and CD34+Robo4high population fell into CD38− fraction, which enriches human HSCs. Bone marrow transplantation experiments revealed that Robo4+ fraction of murine KSL cells had long-term repopulating activity, while Robo4−KSL cells not. Although both Robo4+ and Robo4− CD34−KSL cells repopulated murine hematopoietic system for long-term, Robo4+CD34−KSL cells achieved higher chimerism after repopulation compared with Robo4−CD34−KSL. To investigate the physiological role of Robo4 in HSC homeostasis, we next examined the expression of Slit2 in hematopoietic system. Interestingly, Slit2 is specifically expressed in bone marrow stromal cells, but not in hematopoietic cells. Moreover, Slit2 is induced in osteoblasts, a critical cellular component composing HSC niche, in response to myelosuppressive stress such as 5FU treatment. These results indicate that Robo4 is expressed in murine and human hematopoietic HSCs and useful for HSC purification, and Robo4 - Slit2 system may play a role in HSC physiology in niche environment under hematopoietic stress.

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Marcos-Mondejar, P., S. Peregrin, J. Y. Li, L. Carlsson, S. Tole, and G. Lopez-Bendito. "The Lhx2 Transcription Factor Controls Thalamocortical Axonal Guidance by Specific Regulation of Robo1 and Robo2 Receptors." Journal of Neuroscience 32, no. 13 (March 28, 2012): 4372–85. http://dx.doi.org/10.1523/jneurosci.5851-11.2012.

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Lopez-Bendito, G., N. Flames, L. Ma, C. Fouquet, T. Di Meglio, A. Chedotal, M. Tessier-Lavigne, and O. Marin. "Robo1 and Robo2 Cooperate to Control the Guidance of Major Axonal Tracts in the Mammalian Forebrain." Journal of Neuroscience 27, no. 13 (March 28, 2007): 3395–407. http://dx.doi.org/10.1523/jneurosci.4605-06.2007.

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Verissimo, Ana Raquel, John M. J. Herbert, Victoria L. Heath, John A. Legg, Helen Sheldon, Maud Andre, Rajeeb Kumar Swain, and Roy Bicknell. "Functionally defining the endothelial transcriptome, from Robo4 to ECSCR." Biochemical Society Transactions 37, no. 6 (November 19, 2009): 1214–17. http://dx.doi.org/10.1042/bst0371214.

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We have applied search algorithms to expression databases to identify genes whose expression is restricted to the endothelial cell. Such genes frequently play a critical role in endothelial biology and angiogenesis. Two such genes are the roundabout receptor Robo4 and the ECSCR (endothelial-cell-specific chemotaxis regulator). Endothelial cells express both Robo1 and Robo4, which we have knocked down using siRNA (small interfering RNA) and then studied the effect in a variety of in vitro assays. Both Robo4 and Robo1 knockdown inhibited in vitro tube formation on Matrigel™. Transfection of Robo4 into endothelial cells increased the number of filopodial extensions from the cell, but failed to do so in Robo1-knockdown cells. Separate immunoprecipitation studies showed that Robo1 and Robo4 heterodimerize. We conclude from this and other work that a heteroduplex of Robo1 and Robo4 signals through WASP (Wiskott–Aldrich syndrome protein) and other actin nucleation-promoting factors to increase the number of filopodia and cell migration. Knockdown of the transmembrane ECSCR protein in endothelial cells also reduced chemotaxis and impaired tube formation on Matrigel™. Yeast two-hybrid analysis and immunoprecipitation studies showed that, in contrast with the roundabouts, ECSCR binds to the actin-modulatory filamin A. We conclude that all three of these genes are critical for effective endothelial cell migration and, in turn, angiogenesis.

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Bernardi Pereira, Gustavo. "Apresentação Robson." Revista Latino-Americana de Inovação e Engenharia de Produção 6, no. 10 (December 23, 2018): 3. http://dx.doi.org/10.5380/relainep.v6i10.64083.

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Robles, Nicolás Roberto. "N.R. Robles." Medicina Clínica 114, no. 17 (January 2000): 679. http://dx.doi.org/10.1016/s0025-7753(00)71400-x.

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Brownell, Gordon L. "Robley Evans." Physics Today 49, no. 9 (September 1996): 109–10. http://dx.doi.org/10.1063/1.2807781.

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Mi Je, Eun, Min Gwak, Hyerim Oh, Mi Ryoung Choi, Youn Jin Choi, Sug Hyung Lee, and Nam Jin Yoo. "Frameshift mutations of axon guidance genes ROBO1 and ROBO2 in gastric and colorectal cancers with microsatellite instability." Pathology 45, no. 7 (December 2013): 645–50. http://dx.doi.org/10.1097/pat.0000000000000007.

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Romano, Eloisa, Mirko Manetti, Irene Rosa, Bianca Saveria Fioretto, Lidia Ibba-Manneschi, Marco Matucci-Cerinic, and Serena Guiducci. "Slit2/Robo4 axis may contribute to endothelial cell dysfunction and angiogenesis disturbance in systemic sclerosis." Annals of the Rheumatic Diseases 77, no. 11 (July 18, 2018): 1665–74. http://dx.doi.org/10.1136/annrheumdis-2018-213239.

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ObjectiveIn systemic sclerosis (SSc), early microvascular injury is followed by impaired angiogenesis and peripheral capillary loss. Here, we investigated the possible contribution of the neurovascular guidance molecule Slit2 and its Roundabout (Robo) receptors to SSc-related endothelial cell dysfunction.MethodsCirculating Slit2 levels were measured in patients with SSc and healthy controls. Slit2, Robo1 and Robo4 expression was investigated in SSc and healthy skin biopsies and explanted dermal microvascular endothelial cells (MVECs). Slit2/Robo4 function in MVEC angiogenesis was studied by cell viability, wound healing and capillary-like tube formation assays.ResultsCirculating Slit2 was significantly increased in either SSc or patients with a very early diagnosis of SSc (VEDOSS) compared with controls. Interestingly, serum Slit2 levels were raised in patients with VEDOSS with nailfold videocapillaroscopy (NVC) abnormalities, while they were similar in VEDOSS with normal NVC and controls. In SSc, Slit2 and Robo4 expression was upregulated in clinically affected skin and explanted MVECs in respect to controls. The angiogenic performance of healthy MVECs was significantly reduced after challenge with recombinant human Slit2 or SSc sera. These inhibitory effects were significantly attenuated when SSc sera were preincubated with an anti-Slit2 blocking antibody. In vitro angiogenesis was severely compromised in SSc-MVECs and could be significantly ameliorated by Slit2 neutralisation or ROBO4 gene silencing. Slit2/Robo4 axis interfered with angiogenesis through the inhibition of Src kinase phosphorylation.ConclusionsIn SSc, increased circulating levels of Slit2 and activation of the Slit2/Robo4 antiangiogenic axis may contribute to peripheral microangiopathy since the very early phase of the disease.

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Roberto Robles, Nicolás. "N. Roberto Robles." Medicina Clínica 114, no. 11 (January 2000): 439. http://dx.doi.org/10.1016/s0025-7753(00)71324-8.

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Sancho Rof, J. M. "Rafael García Robles." Hipertensión y Riesgo Vascular 21, no. 5 (January 2004): 279. http://dx.doi.org/10.1016/s1889-1837(04)71492-0.

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Ruilope, L. M. "Rafael García Robles." Hipertensión y Riesgo Vascular 21, no. 5 (January 2004): 280. http://dx.doi.org/10.1016/s1889-1837(04)71493-2.

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Robson, Jeremy. "Vigilby Jeremy Robson." Jewish Quarterly 62, no. 3 (July 3, 2015): 58. http://dx.doi.org/10.1080/0449010x.2015.1084694.

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Rowell, Charles H. "Amber Robles-Gordon." Callaloo 38, no. 4 (2015): 855–57. http://dx.doi.org/10.1353/cal.2015.0112.

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Robson, Martin C. "Welcome Dr. Robson." Journal of Burn Care & Rehabilitation 6, no. 4 (July 1985): 321. http://dx.doi.org/10.1097/00004630-198507000-00001.

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32

Souter, Vivienne, Katon Jodie, Angela Chien, Ellen Kauffman, and Kristin Sitcov. "The Robson Classification." Obstetrics & Gynecology 127 (May 2016): 131S. http://dx.doi.org/10.1097/01.aog.0000483531.18218.6d.

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33

Robson, Ian. "Profile: Ian Robson." Astronomy & Geophysics 49, no. 6 (December 2008): 6.10. http://dx.doi.org/10.1111/j.1468-4004.2008.49610.x.

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34

Doig, A., A. Lambie, and R. Winney. "James Scott Robson." BMJ 341, jul07 2 (July 7, 2010): c3535. http://dx.doi.org/10.1136/bmj.c3535.

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35

Ghosh, Susmita, Amlan Ghosh, Guru Prasad Maiti, Neyaz Alam, Anup Roy, Susanta Roychoudhury, and Chinmay Kumar Panda. "Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications." Human Genetics 125, no. 2 (December 24, 2008): 189–98. http://dx.doi.org/10.1007/s00439-008-0610-9.

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36

Xu, Rifu, Ning Qin, Xiaoxing Xu, Xue Sun, Xiaoxia Chen, and Jinghua Zhao. "Implication of SLIT3-ROBO1/ROBO2 in granulosa cell proliferation, differentiation and follicle selection in the prehierarchical follicles of hen ovary." Cell Biology International 42, no. 12 (October 17, 2018): 1643–57. http://dx.doi.org/10.1002/cbin.11063.

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37

Abrahams, Brendan F., Stuart R. Batten, and Deanna M. D'Alessandro. "Professor Richard Robson FAA." Australian Journal of Chemistry 72, no. 10 (2019): 729. http://dx.doi.org/10.1071/chv72n10_fo.

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38

Robson, Sara. "My week: Sara Robson." Veterinary Record 180, no. 4 (January 27, 2017): i—ii. http://dx.doi.org/10.1136/vr.j374.

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39

Englund, Camilla, Pär Steneberg, Lyudmila Falileeva, Nikos Xylourgidis, and Christos Samakovlis. "Attractive and repulsive functions of Slit are mediated by different receptors in theDrosophilatrachea." Development 129, no. 21 (November 1, 2002): 4941–51. http://dx.doi.org/10.1242/dev.129.21.4941.

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Oxygen delivery in many animals is enabled by the formation of unicellular capillary tubes that penetrate target tissues to facilitate gas exchange. We show that the tortuous outgrowth of tracheal unicellular branches towards their target tissues is controlled by complex local interactions with target cells. Slit, a phylogenetically conserved axonal guidance signal, is expressed in several tracheal targets and is required both for attraction and repulsion of tracheal branches. Robo and Robo2 are expressed in different branches, and are both necessary for the correct orientation of branch outgrowth. At the CNS midline, Slit functions as a repellent for tracheal branches and this function is mediated primarily by Robo. Robo2 is necessary for the tracheal response to the attractive Slit signal and its function is antagonized by Robo. We propose that the attractive and repulsive tracheal responses to Slit are mediated by different combinations of Robo and Robo2 receptors on the cell surface.

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40

Dos Santos Pinto, Jonathas Rodrigo, Maria Lúcia Góes Araújo, Robson Andrade Rosa, Jadson Pinheiro Santos, Ana Rosa Da Rocha Araújo, and José Milton Barbosa. "ESPACIALIZAÇÃO DAS CAPTURAS DE ROBALO (Centropomus spp) ( CENTROPOMIDAE - PERCIFORMES ) NO ESTUÁRIO DO RIO SERGIPE." Arquivos de Ciências do Mar 51, no. 2 (April 2, 2019): 72. http://dx.doi.org/10.32360/acmar.v51i2.33177.

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Os robalos ocorrem no estuário do rio Sergipe e têm importância nas capturas da pesca artesanal, no porto do Bairro Industrial, em Aracaju, com total desembarcado de 1,62 t em 2014. O objetivo deste trabalho foi analisar as capturas de robalo, no estuário do Rio Sergipe. Os dados de produção foram obtidos através dos registros de desembarques, no Bairro Industrial, de Abril/2016 a Dezembro/2017. Um total de 562 indivíduos foi coletado para obtenção de dados biométricos (CT, PT) e identificados. Para as duas espécies mais representativas, nos desembarques, foram estabelecidas a distribuição de frequência, a relação peso-comprimento e a média mensal do fator de condição K. Os dados de captura por unidade de esforço (CPUE), calculados para cada desembarque, foram LOG transformados (LOGCPUE+1) e comparados com ANOVA. As espécies de robalos presentes nas capturas foram o robalo-corcunda Centropomus parallelus (62% dos indivíduos), robalo-furador C. undecimalis (35%) e robalo-alfaiate C. pectinatus (3%). C. parallelus apresentou amplitude de CT de 20,0 a 60,0 cm. A média do fator de condição K para os indivíduos com CT > 28,0 cm foi de 10,7±1,1. A amplitude de CT de C. undecimalis foi de 20,0 a 105,0 cm, com K médio de 3,25±0,28. Para ambas as espécies, houve uma contribuição significativa de indivíduos abaixo do tamanho de primeira maturação. O pequeno tamanho de malha do arrasto de praia (20 mm) pode estar contribuindo para presença significativa de indivíduos de pequeno porte nas capturas. As principais áreas de captura de robalo, no Rio Sergipe, estão situadas em locais com alta concentração de matéria orgânica e baixos teores de oxigênio. Para rede de arrasto de praia, o período pluviométrico influenciou na variação da CPUE. A maioria das capturas das redes de emalhe se concentrou no canal do rio Sergipe e foi menos influenciada pela redução do habitat, no período seco.

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41

Aulia, Lalu Muhammad Fatwa, Suryo Adi Wibowo, and Nurlaily Vendyansyah. "PENERAPAN IoT PADA RANCANG BANGUN SISTEM MINIATUR ROBOT PEMADAM API UNTUK MEMBANTU PROSES EVALUASI PRA EVAKUASI." JATI (Jurnal Mahasiswa Teknik Informatika) 5, no. 1 (February 28, 2021): 253–60. http://dx.doi.org/10.36040/jati.v5i1.3307.

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Pencarian korban di bangunan reruntuhan tentu sangat membahayakan, tentu saaja karena bangunan yang mudah roboh dan sulit dijangkau manusia, karena keterbatasan ruang dan informasi tentang bahaya yang didapat dari suatu bangunan tersebut seperti kebocoran gas beracun, gas yang mudah terbakar, dan bangunan yang dapat roboh sewaktu waktu, struktur bangunan reruntuhan yang rumit sehingga diperlukan evaluasi terlebih dahulu agar mendapatkan informasi yang diperlukan Maka dibuat pengembangan miniatur robot IoT (Intenet of Things) beroda yang dapat memonitoring kondisi visual menggunakan esp32-cam dan mengambil data dari sensor yang diperlukan seperti sensor gas, api, suhu, dan jarak. Kondisi informasi data yang ditangkap disekitar sensor pada robot dikirim menggunakan modul esp8266 ke website monitoring dan dikontrol menggunakan remote control dengan modul radio yaitu nRF24L01 sebagai media komunikasi wireless antara robot dengan remote control. Hasil pengujian sensor ultrasonik (HC-SR04) memiliki rata-rata error yaitu sebesar 2,75%, Sensor gas (MQ2) rata-rata persentase error sebanyak 1,93%, Sensor api maksimal hanya mampu mendeteksi api dari korek gas sejauh 30cm, delay pengiriman data sensor dari robot melalui esp2866 ke web memiliki selama 5 - 6 detik. Sensor dht11 pada ruangan menggunakan pendingin ruangan memilikir rata-rata error sebesar 4% dan pada ruangan tidak menggunakan pendingin ruangan sebesar 3,12%. remote control dapat terhubung dengan robot jika halangan kurang dari 7 tembok, website dapat berjalan baik pada beberapa web browser yang diujikan (Opra, Google Chrome dan Microsoft Edge).

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42

Fakhriza, Muhammad, Muhammad Hadi Senoadji, Adelia Ananda, and Khairani Maudi Pangestu. "Penerapan Fuzzy Logic Pada Mobile Robot Sederhana." JURNAL ARMADA INFORMATIKA 3, no. 1 (August 1, 2019): 70–79. http://dx.doi.org/10.36520/jai.v3i1.43.

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The application of fuzzy logic can be implemented in making simple robots, where the method used is the sugeno method, robo can move automatically, the robot is designed in a round shape has a tire that can move forward and backward, left and right, the robo can maintain a safe distance with the object in front of it. The results of this test indicate that the robot can work well with normal movement Keywords : fuzzy logic

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43

Sellin, Eric, Emmanuel Robles, and Giuliana Toso Rodinis. "Il Teatro di Emmanuel Robles." Modern Language Studies 16, no. 3 (1986): 321. http://dx.doi.org/10.2307/3194915.

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44

Gale, George A. "Birds of Thailand Craig Robson." Auk 121, no. 4 (October 2004): 1299–300. http://dx.doi.org/10.2307/4090503.

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45

Sancho, J. M. "Rafael García Robles: in memoriam." Endocrinología y Nutrición 51, no. 7 (January 2004): 447. http://dx.doi.org/10.1016/s1575-0922(04)74644-6.

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46

Castree, Noel, and Iain Deas. "Brian Turnbull Robson, 1939–2020." Geographical Journal 186, no. 3 (August 16, 2020): 355–57. http://dx.doi.org/10.1111/geoj.12355.

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47

ASATANI, Satoshi, Nobuyuki TANAKA, and Jun MIYAKE. "3P1-I05 RoboCox(Musculoskeletal modeling)." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2014 (2014): _3P1—I05_1—_3P1—I05_2. http://dx.doi.org/10.1299/jsmermd.2014._3p1-i05_1.

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48

Gerson, Lauren B., Jeff L. Fidler, David R. Cave, and Jonathan A. Leighton. "Response to Perez-Cuadrado Robles." American Journal of Gastroenterology 111, no. 2 (February 2016): 294–95. http://dx.doi.org/10.1038/ajg.2015.428.

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49

E.K. "Obituaries: ALAN ROBSON (1915–1987)." French Studies XLII, no. 4 (1988): 505–6. http://dx.doi.org/10.1093/fs/xlii.4.505.

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50

Mason, Tom. "Wiliam Wallace Robson 1923–1993." Cambridge Quarterly XXIII, no. 2 (1994): 155–66. http://dx.doi.org/10.1093/camqtly/xxiii.2.155.

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