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Journal articles on the topic 'Roches dures'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Puech, Alain, and Bibiana Quiterio-Mendoza. "Caractérisation des massifs rocheux pour le dimensionnement de pieux forés en mer." Revue Française de Géotechnique, no. 158 (2019): 5. http://dx.doi.org/10.1051/geotech/2019011.

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Les pieux forés et cimentés sont une solution envisagée comme fondations de structures marines dans les roches tendres à dures rencontrées au large des côtes françaises. Le dimensionnement des pieux au rocher est un exercice délicat. L’exécution de séries d’essais de cisaillement d’interface à rigidité constante (dits essais CNS) est considérée comme une approche réaliste pour estimer la résistance au cisaillement de l’interface roche-ciment sous chargements statiques et cycliques. Les essais CNS sont conditionnés par deux paramètres clés qui sont liés aux caractéristiques du massif rocheux :

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Habib, Pierre. "Utilisation des roches tendres et des roches dures pour l'isolement des dechets radioactifs." Geotecnia, no. 71 (June 20, 1994): 01–24. http://dx.doi.org/10.14195/2184-8394_71_1.

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Le principe de l'isolement des déchets radioactifs dans une formation géologique est simple. L'eau étant le principal vecteur de la migration des ions, il suffit de placer les radionucléides en profondeur au sein d'un milieu tres peu perméable, dans une région ou le gradient hydraulique est tres petit - ce qui signifie, en général, sous une plaine - pour faire en sorte que les nucléides ne puissent s'échapper et rejoindre la biosphere qu'après un temps suffisamment long pour qu'ils aient perdu l'essentiel de leur activité, ce qui peut prendre 100 000 ou 1000000 d'années. II faut ensuite que le

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Meilliez, Francis, and Jean-Jacques Belin. "Territoire et matériaux, géologie et histoire : visite en pays de Pévèle." Annales de la Société géologique du Nord - (2e Série), Tome 29, no. 29 (December 1, 2022): 121–32. http://dx.doi.org/10.54563/asgn.1932.

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Un territoire, en surface, est déterminé par sa composition et sa structure : la Pévèle rassemble des roches tendres (argiles, sables) au cœur d’une synforme largement ouverte, esquissée par les niveaux crayeux du Crétacé supérieur, discordants sur un socle paléozoïque, structuré par l’orogenèse varisque. L’observation d’églises de plusieurs villages conduit à s’interroger sur la provenance des pierres dures qui ont été nécessaires, et sur leurs conditions d’acheminement il y a environ 1 000 ans.

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Lasm, Théophile, and Moumtaz Razack. "Lois d'échelle dans la fracturation de roches dures cristallines et dans le réseau hydrographique associé." Comptes Rendus de l'Académie des Sciences - Series IIA - Earth and Planetary Science 333, no. 4 (2001): 225–32. http://dx.doi.org/10.1016/s1251-8050(01)01632-9.

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Claud, Émilie, Vincent Mourre, Céline Thiébaut, and Michel Brenet. "Le recyclage au Paléolithique moyen. Des bifaces et des nucléus utilisés comme percuteurs." Archeopages 29 (2010): 6–15. https://doi.org/10.4000/13esb.

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La réutilisation d’objets usagés en pierre taillée et des sous-produits des activités de taille dès le Paléolithique moyen est un phénomène observé depuis les années 1960. L’hypothèse que des bifaces et des nucléus avaient été utilisés par les Néandertaliens selon des modalités complètement différentes de leur fonctionnement initial a dès lors été posée. Afin de la vérifier, une démarche expérimentale a été mise en œuvre dans le cadre d’un PCR intitulé « Des traces et des hommes » pour disposer d’un référentiel permettant de comparer les traces relevant de différentes activités (travail en per

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Pelegrin, Jacques, Yoshihiro Aita, and Ishiro Yamanaka. "Yokomichi : Une collection du Paléolithique supérieur du Japon abordée selon un œil technologique français." Journal of Lithic Studies 4, no. 2 (2017): 447–73. http://dx.doi.org/10.2218/jls.v4i2.2551.

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Depuis les années 1970, l’étude des collections lithiques préhistoriques a vécu en France une profonde modernisation. André Leroi-Gourhan, d’abord intéressé par les techniques traditionnelles, prit pour objectif d’appréhender les activités techniques menées dans un site par un groupe préhistorique, dans une perspective ainsi dénommée « palethnologique ». Il a aussi promu la notion de chaîne opératoire introduite auparavant par Marcel Mauss. Mais ce sont les expérimentateurs de la taille des roches dures, F. Bordes et J. Tixier, qui vont permettre d’enrichir cette notion de ses applications con

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Kouayep Lawou, Sylvain, Philippe Samba Assomo, Russel Gaïthan Kue Kue, and Véronique Kamgang Kabeyene Beyala. "Modelling structural of groundwater behaviour in the crystalline aquifer of Pan-African granitoids at Bonis open pit quarry (East-Cameroon)." Journal of the Cameroon Academy of Sciences 21, no. 2 (2025): 93–107. https://doi.org/10.4314/jcas.v21i2.2.

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This paper aims to build the hydrogeological model in the crystalline aquifer rock mass made up of granitoids, governed by Sanaga’s fault network printed out during the Pan-African age at the Bonis’ concrete open pit quarry. Different geological successions as well as structural defects have been investigated. Moreover, electrical tomography by geophysical survey has permitted to access the piezometric level of groundwater together with the hydrogeological facilities built on site. Finaly physicochemical analysis of 6 groundwater samples were performed in order to assess pollution. The main ge

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8

Di Bernardini, Gian Luigi. "Roger-Yves Roche, Photofictions. Perec, Modiano, Duras, Goldschmidt, Barthes." Studi Francesi, no. 163 (LV | I) (May 1, 2011): 215. http://dx.doi.org/10.4000/studifrancesi.6102.

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Pinto, Lívia Aparecida Gonçalves, and José Margarida da Silva. "Aprendizagem de máquina na determinação de parâmetros de resistência de filitos brandos." Research, Society and Development 12, no. 1 (2023): e19012139693. http://dx.doi.org/10.33448/rsd-v12i1.39693.

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Aspectos geológico-geotécnicos devem ser levados em consideração desde os estudos de exploração geológica, em empreendimentos mineiros. Alguns acidentes ocorridos em minas, nas últimas décadas, poderiam ser evitados, caso as condições geológico-geotécnicas do maciço fossem compreendidas. Ainda existe grande dificuldade em se classificar alguns tipos de rochas, sobretudo as rochas consideradas brandas, por meio dos sistemas de classificação geomecânica conhecidos. A grande maioria das classificações existentes foram desenvolvidos baseadas em características de rochas duras. Para maciços rochoso

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Ccopa Ybarra, Luis Antonio, Andre Luis Molisani, Daniel Rodrigues, and Humberto Naoyuki Yoshimura. "O processo de infiltração em ferramentas de perfuração de rochas com o uso dos pós de tungstênio e carboneto de tungstênio: as características e resultados da microestrutura e dureza do cermet." Exacta 7, no. 1 (2009): 57–76. http://dx.doi.org/10.5585/exacta.v7i1.1377.

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No processo de infiltração para a fabricação de ferramentas de perfuração de rocha (coroa), analisaram-se três procedimentos com utilização de três pós de matrix: dois à base de carbonetos de tungstênio e um à base de tungstênio, pelos quais se investigaram os efeitos de suas características, os da microestrutura e a dureza de um cermet. As amostras na forma de coroa foram preparadas pela técnica da infiltração, em que o pó matrix, compactado em um molde de grafita, montado com um tubo (carcaça) de aço, foi infiltrado por uma liga de cobre para consolidar o metal duro e ligá-lo à carcaça de aç

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Ccopa Ybarra, Luis Antonio, Andre Luis Molisani, Daniel Rodrigues, and Humberto Naoyuki Yoshimura. "O processo de infiltração em ferramentas de perfuração de rochas com o uso dos pós de tungstênio e carboneto de tungstênio: as características e resultados da microestrutura e dureza do cermet DOI: 10.5585/exacta.v7i1.1377." Exacta 7, no. 1 (2009): 57–76. http://dx.doi.org/10.5585/exactaep.v7i1.1377.

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No processo de infiltração para a fabricação de ferramentas de perfuração de rocha (coroa), analisaram-se três procedimentos com utilização de três pós de matrix: dois à base de carbonetos de tungstênio e um à base de tungstênio, pelos quais se investigaram os efeitos de suas características, os da microestrutura e a dureza de um cermet. As amostras na forma de coroa foram preparadas pela técnica da infiltração, em que o pó matrix, compactado em um molde de grafita, montado com um tubo (carcaça) de aço, foi infiltrado por uma liga de cobre para consolidar o metal duro e ligá-lo à carcaça de aç

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Higham, Charles. "Bérénice Bellina. Cultural Exchange between India and Southeast Asia: production and distribution of hard stone ornaments (VI c. BC – VI c. AD)/Echanges culturels entre l'Inde et l'Asie du Sud-Est: production et distribution des parures en roches dures du VIè siècle avant notre ère au VIè siècle de notre ère. 126 pages, 3 maps, CD-ROM. 2007. Paris: Maison des sciences de l'homme/Epistèmes; 978-2-7351-1127-5 paperback €29." Antiquity 82, no. 315 (2008): 230–31. http://dx.doi.org/10.1017/s0003598x00096691.

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Nascimento, Vandetania Xavier, Claúdia Maria Salvador Vasconcelos, and Marcela Rejane Silva Ferreira. "ESTUDO DA EROSÃO MARINHA NA PRAIA DE BARRA DE MAXARANGUAPE/RN." Revista da Casa da Geografia de Sobral (RCGS) 21, no. 2 (2019): 33–37. http://dx.doi.org/10.35701/rcgs.v21n2.598.

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A zona costeira é uma área que está em um equilíbrio dinâmico em decorrência da intermediação de fatores naturais e antrópicos, no entanto as consequências nocivas promovidas pelos agentes naturais tem sua dinâmica própria, e causa múltiplas reações que independem da ação humana, contudo, muitas vezes acelerados ou aumentados pela intervenção do homem. Geologicamente, toda faixa costeira do estado potiguar é constituída por rochas sedimentares de idade Cretácea, recoberta por rochas da Formação Barreiras e sedimentos Quaternários, como dunas, rochas praiais, terraços marinhos e aluvionares com

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14

Ritschl, V., T. Stamm, D. Aletaha, et al. "SAT0608-HPR EULAR POINTS TO CONSIDER FOR THE DETECTION, ASSESSMENT AND MANAGEMENT OF NON-ADHERENCE IN PEOPLE WITH RHEUMATIC AND MUSCULOSKELETAL DISEASES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1264.2–1264. http://dx.doi.org/10.1136/annrheumdis-2020-eular.787.

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Background:Non-adherence to medication and non-pharmacological interventions precludes reaching an optimal outcome. 30 to 80% of patients with rheumatic and musculoskeletal diseases (RMDs) do not adhere to their recommended treatment regimens.Objectives:The objective of this EULAR task force was to establish recommendations/points to consider (PtC) for the detection, assessment and management of non-adherence in people with RMDs.Methods:A EULAR task force (TF) was established, and the EULAR standardised operating procedures for the development of PtCs were followed. The TF included rheumatolog

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Burmester, G. R., J. M. Alvaro-Gracia, N. Betteridge, et al. "THU0579 “EVOLVING THE MANAGEMENT OF RA” PROGRAMME: EDUCATIONAL TOOLS TO SUPPORT DAILY PRACTICE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 531.1–531. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1219.

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Background:The eRA (evolving the management of RA) programme was initiated in Europe to provide practical educational tools that address unmet needs in the management of rheumatoid arthritis (RA). Several eRA tools – covering early access to care, management of comorbidities, treat-to-target strategies, and patient empowerment – are available to the rheumatology community. Through ongoing activities, the eRA Steering Committee (SC) identified a need for tools on non-pharmacological management of RA.Objectives:To improve accessibility to eRA tools for rheumatology professionals; to review the e

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Tâmega, Frederico Tapajós de Souza, and Marcia Abreu de Oliveira Figueiredo. "DISTRIBUIÇÃO DAS ALGAS CALCÁRIAS INCRUSTANTES (CORALLINALES, RHODOPHYTA) EM DIFERENTES HABITATS NA PRAIA DO FORNO, ARMAÇÃO DOS BÚZIOS, RIO DE JANEIRO." Rodriguésia 56, no. 87 (2005): 123–32. http://dx.doi.org/10.1590/2175-78602005568709.

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RESUMO As algas calcárias incrustantes ocupam grande variedade de habitats nos substratos duros. Neste estudo as características morfológicas destas algas foram relacionadas à influência de fatores ambientais. Coletas foram realizadas na Praia do Forno (RJ) utilizando transectos de linha com 10 m de comprimento com 30 pontos aleatórios para quantificação das algas calcárias. Aspectos morfológicos externos foram observados no estereomicroscópio e seções histológicas preparadas para identificação dos grupos/táxons. Seis grupos morfo-funcionais foram identificados sendo quatro mais abundantes: Hy

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Castro, David Lopes de, João Andrade dos Reis Júnior, Washington Luiz Evangelista Teixeira, Victor De Albuquerque Silva, and Francisco Pinheiro Lima Filho. "GROUND-PENETRATING RADAR IMAGING TECHNIQUES APPLIED IN 3D ENVIRONMENT: EXAMPLE IN INACTIVE DUNES." Revista Brasileira de Geofísica 32, no. 2 (2014): 273. http://dx.doi.org/10.22564/rbgf.v32i2.482.

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ABSTRACT. The increased use of Ground-Penetrating Radar (GPR) in several areas of knowledge has introduced an impressive number of new methodologicalprocedures, adapted from other areas, such as seismic reflection, or developed specifically for the GPR. A summary of the advances in acquisition, processing andinterpretation of GPR data is presented in this paper. Some of the techniques were applied to a 3D GPR survey in a study area, whose substrate is composed bysedimentary sequences of paleodunes or inactive dunes, located in the outer courtyard of the Department of Geology (DEGEO) of the Uni

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Fleischmann, R., I. H. Song, J. Enejosa, et al. "THU0201 LONG-TERM SAFETY AND EFFECTIVENESS OF UPADACITINIB OR ADALIMUMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS AT 72 WEEKS FROM THE SELECT-COMPARE STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 323. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1418.

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Background:In the SELECT-COMPARE study in rheumatoid arthritis (RA) patients with inadequate response to methotrexate (MTX), upadacitinib (UPA), a Janus Kinase (JAK) 1-selective inhibitor, showed significant improvements in treatment of signs and symptoms when compared to placebo (PBO) and adalimumab (ADA) up to 48 weeks.1Objectives:To report safety and efficacy of UPA vs ADA up to 72 weeks in patients with RA from the ongoing long-term extension (LTE) of SELECT-COMPARE.Methods:Patients were randomized to once daily (QD) UPA 15 mg, PBO, or ADA 40 mg every other week, with all patients continui

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Robson, J., C. Almeida, J. Dawson, et al. "POS0003 DEVELOPMENT AND VALIDATION OF A DISEASE SPECIFIC PATIENT REPORTED OUTCOME FOR GIANT CELL ARTERITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 214.2–214. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1769.

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BackgroundGiant cell arteritis (GCA) is caused by inflammation of the blood vessels of the head and neck; patients can present with cranial, ocular or large vessel vasculitis involvement. Treatment is with glucocorticoids, steroid sparing agents and biologics to control inflammation and protect sight.ObjectivesThe aim of this study was to produce a validated disease specific PROM for patients with GCA, to capture the impact of GCA and its treatment on health-related quality of life.MethodsPatients with clinician- confirmed GCA from the UK, either diagnosed in the last three years or with a fla

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Dures, E., B. Farisogullari, E. Santos, et al. "POS0370 2023 EULAR RECOMMENDATIONS FOR THE MANAGEMENT OF FATIGUE IN PEOPLE WITH INFLAMMATORY RHEUMATIC AND MUSCULOSKELETAL DISEASES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 437–38. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2793.

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BackgroundFatigue is prevalent in people with inflammatory rheumatic and musculoskeletal diseases (I-RMDs) and recognised as one of the most challenging symptoms to manage [1]. The existence of multiple factors associated with fatigue, the lack of clarity around underlying pathophysiological mechanisms and the limited evidence about what helps have led to a multifaceted and often fragmented approach to symptom management. However, there are no recommendations for fatigue management in people with I-RMDs, and this lack of guidance has been challenging for those living with fatigue as well as fo

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Farisogullari, B., E. Santos, E. Dures, and P. Machado. "POS1087 EFFICACY OF PHARMACOLOGICAL INTERVENTIONS: A SYSTEMATIC REVIEW INFORMING THE 2023 EULAR RECOMMENDATIONS FOR THE MANAGEMENT OF FATIGUE IN PEOPLE WITH INFLAMMATORY RHEUMATIC AND MUSCULOSKELETAL DISEASES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 867.1–867. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1591.

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BackgroundThere is evidence that pharmacological interventions, including biologic therapies, can improve inflammation, disease activity and function in inflammatory rheumatic and musculoskeletal diseases (I-RMDs), and fatigue has increasingly been included as a secondary outcome of I-RMDs clinical trials. However, no systematic review (SR) has established the evidence for the pharmacological management of fatigue in people with I-RMD [1,2].ObjectivesTo identify the best evidence on the efficacy of pharmacological interventions in reducing fatigue in people with I-RMDs and to summarise their s

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Burmester, G. R., D. Aletaha, J. Pope, et al. "THU0194 CHARACTERISATION OF DEPTH OF RESPONSE, INCLUDING 50% IMPROVEMENT IN ACR COMPONENTS AT WEEK 12 AND REMISSION AT WEEK 24, FOLLOWING TREATMENT WITH FILGOTINIB COMPARED WITH METHOTREXATE OR ADALIMUMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 316.1–317. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2236.

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Background:The oral, potent, selective JAK1 inhibitor filgotinib (FIL) showed favorable efficacy at week (W)12 and W24 of treatment for rheumatoid arthritis (RA) compared with methotrexate (MTX) monotherapy (mono) in FINCH 3 (NCT02886728) and with placebo (PBO) or adalimumab (ADA) in FINCH 1 (NCT02889796).Objectives:50% clinical improvement from baseline at W12 is a key checkpoint for RA treatment.1These post hoc analyses evaluated FIL treatment effect on improvement in ACR components at W12 and remission at W24 in FINCH 3 and FINCH 1.Methods:FINCH 3 and FINCH 1 were global, phase 3, double-bl

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Ostendorf, L., P. Enghard, P. Durek, et al. "AB0138 INCREASED CD38 EXPRESSION LEVELS ON IMMUNE CELL SUBSETS IN SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1369.2–1370. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6531.

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Background:Plasma Cells (PCs) are implicated in the pathogenesis of Systemic Lupus erythematosus (SLE) and their targeting proved a promising treatment modality. As there is a monoclonal therapeutic antibody targeting CD38 licensed for clinical use in multiple myeloma, plasma cell depletion via CD38 seems to represent a promising path in SLE treatment. While CD38 Is highly expressed on plasmacells, it is present on the surface of subsets of T and B lymphocytes as well as myeloid cells.Objectives:Here we aim to identify the differential expression of CD38 on peripheral blood leukocytes in SLE c

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Fleischmann, R., E. Mysler, L. Bessette, et al. "POS0087 LONG-TERM SAFETY AND EFFICACY OF UPADACITINIB OR ADALIMUMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS AT 3 YEARS FROM THE SELECT-COMPARE STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 251.1–252. http://dx.doi.org/10.1136/annrheumdis-2021-eular.535.

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Background:In the SELECT-COMPARE study, the Janus kinase inhibitor, upadacitinib (UPA), demonstrated significant improvements in the signs and symptoms of rheumatoid arthritis (RA) when administered at 15 mg once daily (QD) on background methotrexate (MTX) compared with adalimumab (ADA) plus MTX at Week 12 that were maintained through 72 weeks in patients with prior inadequate response to MTX.1Objectives:To assess the long-term safety and efficacy of UPA vs ADA over 3 years in the ongoing long-term extension (LTE).Methods:Patients receiving background MTX were randomized 2:2:1 to UPA 15 mg QD,

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Peterfy, C., V. Strand, M. C. Genovese, et al. "THU0211 RADIOGRAPHIC OUTCOMES IN PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING UPADACITINIB AS MONOTHERAPY OR IN COMBINATION WITH METHOTREXATE: RESULTS AT 2 YEARS FROM THE SELECT-COMPARE AND SELECT-EARLY STUDIES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 330–31. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1869.

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Background:For patients with rheumatoid arthritis (RA), long-term prevention of structural joint damage is a key treatment goal.1In the SELECT-EARLY and SELECT-COMPARE trials, upadacitinib (UPA), an oral JAK inhibitor, inhibited the progression of structural joint damage at 6 months and 1 year when used either as monotherapy or in combination with methotrexate (MTX) in patients (pts) with active RA.2Objectives:To describe the radiographic progression up to 2 years (96 wks) among pts with RA receiving UPA either as monotherapy or in combination with MTX.Methods:Both the SELECT-EARLY and SELECT-

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Santos, E., B. Farisogullari, E. Dures, and P. Machado. "OP0182-HPR EFFICACY OF NON-PHARMACOLOGICAL INTERVENTIONS: A SYSTEMATIC REVIEW INFORMING THE 2023 EULAR RECOMMENDATIONS FOR THE MANAGEMENT OF FATIGUE IN PEOPLE WITH INFLAMMATORY RHEUMATIC AND MUSCULOSKELETAL DISEASES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 120.1–120. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1627.

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BackgroundSeveral EULAR recommendations for the management of people with specific inflammatory rheumatic and musculoskeletal diseases (I-RMDs) have highlighted the importance of some non-pharmacological interventions in the management of fatigue [1-3]. However, these recommendations are either disease-specific or focusing on a single intervention, and lack an integrated view of the overall evidence for fatigue management with non-pharmacological therapies in the wider context of all I-RMD.ObjectivesTo identify the best evidence on the efficacy of non-pharmacological interventions in reducing

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Hofer, Theresia. "Tibetan Writing from the Socio-linguistic Margins of Tibet." HIMALAYA 43, no. 1 (2023): 42–70. https://doi.org/10.2218/himalaya.2023.8884.

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Through the writings of Tashi and Yangzom, two young deaf Tibetans, and my narrative of our encounters during ethnographic fieldwork at the Lhasa Special School (LSS) in 2016-2017, this article explores their lives, the role of and their views on the Tibetan language. While their writings reproduce important state-endorsed categories for disabled people in China (Kohrman 2005) and of the state’s ‘civilizing project’ of deaf Tibetans (Hofer and Sagli 2017), they also creatively challenge, critique and ultimately escape those terms and categories through their writings and through the creation o

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Durez, P., E. Feist, R. Blanco, et al. "POS0663 THE USE OF EXPOSURE-ADJUSTED EVENT RATES VERSUS EXPOSURE-ADJUSTED INCIDENCE RATES IN ADVERSE EVENT REPORTING: INSIGHTS FROM FILGOTINIB INTEGRATED SAFETY DATA IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 604.1–604. http://dx.doi.org/10.1136/annrheumdis-2022-eular.138.

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BackgroundReporting of treatment-emergent adverse events (TEAEs) in rheumatoid arthritis (RA) clinical trials can be summarized as exposure-adjusted incidence rates (EAIRs) or exposure-adjusted event rates (EAERs). Censored EAIR (EAIR), weighing exposure up to a patient’s first event, is commonly reported; uncensored EAIR (EAIRu), using total exposure time for all patients, can also be used. For EAIR, exposure time can vary by event. In contrast to EAIR(u), the total number of events are used to calculate EAER. The three methods account for different exposures and/or multiple events, which can

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CASTRO, Karine de Souza, Marcelo Martins de MOURA FÉ, and Thaís de Oliveira GUIMARÃES. "SERVIÇOS ECOSSISTÊMICOS ASSOCIADOS ÀS DUNAS INTERIORES DO MUNICÍPIO DE CASA NOVA (BA)." Geosciences = Geociências 43, no. 3 (2024): 421–32. http://dx.doi.org/10.5016/geociencias.v43i3.18361.

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RESUMO - Os serviços ecossistêmicos são heranças e funções da natureza que beneficiam a população, sendo disponibilizados por meio do ambiente, através dos componentes bióticos e abióticos. Como se sabe, há na natureza uma variedade de elementos abióticos, sendo eles: geológicos (rochas, minerais e fósseis); geomorfológicos (formas de relevo, topografia e procedimentos físicos); pedológicos (solos) e os hidrológicos (água). A identificação dos principais serviços presentes nas dunas interiores auxiliará na sua conservação, possibilitando à continuidade de oferta dos seus serviços à sociedade.

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Fleischmann, R. M., J. Swierkot, S. Penn, et al. "POS0849 LONG-TERM SAFETY AND EFFICACY OF UPADACITINIB OR ADALIMUMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS: 5-YEAR DATA FROM THE SELECT-COMPARE STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 725–26. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2615.

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BackgroundUpadacitinib (UPA) is an oral reversible Janus kinase inhibitor. In patients (pts) with RA, UPA 15 mg once daily (QD) demonstrated better clinical responses at 12 weeks (wks) vs adalimumab (ADA) 40 mg every other week (EOW) in the phase 3 SELECT-COMPARE study; these were maintained through 3 years (yrs) in the ongoing long-term extension (LTE), along with an acceptable safety profile.[1,2]ObjectivesTo assess the safety and efficacy of UPA vs ADA through 5 yrs in the SELECT-COMPARE LTE.MethodsPts receiving background methotrexate were randomized 2:2:1 to UPA 15 mg QD, placebo (PBO), o

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Bridgewater, S., J. Dawson, M. Ndosi, et al. "AB0834 DEVELOPMENT OF A CONCEPTUAL FRAMEWORK FOR A PATIENT REPORTED OUTCOME MEASURE TO CAPTURE PATIENTS’ PERCEPTIONS OF GLUCOCORTICOID THERAPY DURING TREATMENT FOR RHEUMATIC DISEASES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1441.1–1441. http://dx.doi.org/10.1136/annrheumdis-2021-eular.164.

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Background:Glucocorticoids (GCs) are a key treatment for the autoimmune rheumatic diseases; however, they produce numerous physical and psychological side effects.1 The Outcome Measures in Rheumatology (OMERACT) Glucocorticoid Working Group have identified that there are no Patient Reported Outcome Measures (PROMs) for assessing the impact of systemic GC therapy across multiple rheumatic diseases from the patient’s perspective.2,3Objectives:The aim is to explore the impact of GCs on the symptoms and health-related quality of life of adults with rheumatic inflammatory diseases, to inform items

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Ostendorf, L., U. Schneider, M. Urbicht, et al. "AB0385 TARGETING CD38 IN SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1493.3–1493. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5052.

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Background:Depletion of long-lived plasma cells (PC) resembles a novel concept for the treatment of antibody-mediated autoimmune diseases, such as systemic lupus erythematosus (SLE). Therapeutic approaches such as autologuos stem-stem cell transplantation and proteasome inhibition are limited by significant treatment-related toxicity. A novel target for PC depletion is CD38, a surface protein that is highly expressed on plasma cells (PCs) but also activated T-cells and most myeloid cells. Daratumumab is a monoclonal antibody targeting CD38 that is licensed for the treatment of multiple myeloma

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Dobson, J., D. Dockrell, K. Berg, S. Ralston, and H. Harris. "POS0801-HPR GREAT EXPECTATIONS: A FATIGUE MANAGEMENT PROGRAMME CAN ALSO IMPROVE SLEEP QUALITY AND MENTAL WELL-BEING IN RHEUMATIC DISEASE PATIENTS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 694.2–695. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2507.

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BackgroundFatigue is a significant problem for patients with Rheumatic diseases and yet remains overlooked and undertreated[1-3]. It is known to be associated with increased sleep disturbance in this patient group[4]and with poorer mental health[5]. A fatigue management programme (FMP) was developed with the aim of reducing the impact of fatigue on patients. Outcome measures were used to determine whether an improvement in fatigue scores also resulted in an improvement in sleep and mental health.ObjectivesThe primary objective was to evaluate whether a reduction in fatigue corresponded with an

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Machado, P. M., S. Lawson-Tovey, K. Hyrich, et al. "LB0002 COVID-19 VACCINE SAFETY IN PATIENTS WITH RHEUMATIC AND MUSCULOSKELETAL DISEASE." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 199–200. http://dx.doi.org/10.1136/annrheumdis-2021-eular.5097.

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Background:The consequences of the COVID-19 outbreak are unprecedented and have been felt by everyone around the world, including people with rheumatic and musculoskeletal diseases (RMDs). With the development of vaccines, the future is becoming brighter. Vaccines are a key pillar of public health and have been proven to prevent many serious diseases. However, vaccination also raises questions, especially for patients with inflammatory RMDs and/or treated with drugs that influence their immune system.Objectives:Our aim was to collect safety data among RMD patients receiving COVID-19 vaccines.M

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Favalli, E. G., M. H. Buch, J. Galloway, et al. "AB0454 SAFETY OF FILGOTINIB IN PATIENTS WITH RA: LABORATORY ANALYSIS RESULTS FROM A LONG-TERM EXTENSION STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1417–18. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2129.

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BackgroundFilgotinib (FIL) is a Janus kinase (JAK) 1 preferential inhibitor, approved for treatment of moderate to severe active RA in Europe, the UK, and Japan. Graded laboratory abnormalities from placebo-controlled analyses and long-term data on lymphocytes have been reported previously.ObjectivesReport the effect of FIL on laboratory parameters in the FINCH 4 long-term extension (LTE).MethodsSafety was assessed from LTE baseline (BL) to data cutoff (1 Jun 2020) in patients (pts) receiving ≥1 FIL dose (FIL 200 mg [FIL200] or 100 mg [FIL100]) in FINCH 4 (NCT03025308). Laboratory abnormalitie

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Bridgewater, S., M. Ndosi, J. Dawson, et al. "OP0280-HPR VALIDATION OF A NEW GLUCOCORTICOID-SPECIFIC PATIENT REPORTED OUTCOME QUESTIONNAIRE (THE STEROID PRO)." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 184.2–184. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3705.

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BackgroundGlucocorticoids are used in the treatment of a broad range of rheumatic conditions but can have a significant impact on health-related quality of life[1]. In-depth qualitative interviews with patients who have experience of glucocorticoid treatment for their rheumatic disease, from the UK, USA and Australia, were used to develop candidate items for a treatment-specific Patient Reported Outcome Measure (PROM): the Steroid PRO.ObjectivesWe aimed to complete the development and validation of the Steroid PRO through use of a cross-cultural validation study.MethodsThis was a cross-section

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Felten, R., P. M. Duret, E. Bauer, et al. "OP0282 RITUXIMAB ASSOCIATED WITH SEVERE COVID-19 AMONG PATIENTS WITH INFLAMMATORY ARTHRITIDES: A 1-YEAR MULTICENTER STUDY IN 1116 SUCCESSIVE PATIENTS RECEIVING BIOLOGIC AGENTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 170.1–171. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1521.

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Background:At a time when vaccines are being prioritized for individuals most at risk, there is currently no clear evidence that risk of SARS-CoV-2 infection is higher for patients with than without inflammatory arthritides (IA). Biologic use was not associated with worse COVID-19 outcomes for yet but the case of rituximab (RTX) remains an issue, given its immunological long term effect, the role of humoral response against SARS-CoV-2 and its indirect effect on T-cell response. A potential association between rituximab and worse COVID-19 outcomes was raised by case reports and retrospective, d

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Daien, C., M. Krogulec, P. Gineste та ін. "POS0688 PHASE 2A STUDY IN PATIENTS WITH MODERATE-TO-SEVERE RHEUMATOID ARTHRITIS AND INADEQUATE RESPONSE TO MTX AND/OR ANTI-TNFΑ THERAPEUTICS SHOWS THAT ORAL ABX464 50 MG ONCE DAILY IS SAFE, WELL TOLERATED AND SHOWS PROMISING EFFICACY RESULTS". Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 623.1–623. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2286.

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BackgroundABX464 upregulates the expression of the anti-inflammatory microRNA miR-124 and is a first-in-class drug candidate as an oral treatment for moderate-to-severe Rheumatoid Arthritis (RA).ObjectivesThis phase 2a randomized, double blind, placebo controlled, parallel group 12-week study evaluated the safety and preliminary efficacy of ABX464 (50 and 100 mg q.d.), in combination with methotrexate (MTX) in 60 patients (1:1:1 ratio) with moderate-to-severe active RA who have inadequate response to MTX or/and to an anti-TNFα therapy. Patients who completed the 12-week induction phase could r

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Kalmar, Alexandra, Gitta Szabo, Orsolya Galamb, et al. "Abstract 2945: Comprehensive analysis of tissue and plasma-related genetic alterations in Hungarian colorectal cancer patients." Cancer Research 82, no. 12_Supplement (2022): 2945. http://dx.doi.org/10.1158/1538-7445.am2022-2945.

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Abstract Background: Analysis of circulating cell-free DNA (cfDNA) of colorectal cancer (CRC) patients provides an ideal approach to explore genetic alterations in a minimally invasive way. Aims: We aimed to perform a comprehensive analysis of tissue-originated genomic DNA and plasma-derived cfDNA from CRC patients by whole-exome and targeted panel sequencing. Materials & methods: DNA was isolated from tissue and plasma samples of 55 [7 healthy (N), 16 adenomas (AD), and 32 CRC] patients using the High Pure PCR Template Kit (Roche) and the Quick cfDNA Serum & Plasma Kit (Zymo). cfDNA q

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Bettiol, A., I. Mattioli, M. L. Urban, et al. "OP0304 BENRALIZUMAB FOR EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA): RESULTS FROM A EUROPEAN MULTICENTER STUDY ON 121 PATIENTS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 196.1–197. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1510.

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BackgroundEosinophilic granulomatosis with polyangiitis (EGPA) is an ANCA-associated vasculitis characterized by asthma, ear-nose-throat (ENT) manifestations, peripheral hypereosinophilia and systemic vasculitic involvement [1]. Increased serum levels of interleukin 5 (IL-5) have been observed in eosinophilic disorders, including EGPA, and a genome-wide association study identified the IL-5 region as a major EGPA-associated loci [2]. On these bases, an increasing interest is focusing on benralizumab (an IL-5 receptor antagonist approved for severe eosinophilic asthma at the dosage of 30mg ever

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Frédéric, Duhart. "« L'utilisation de la pierre de Bidache au XVIIIe siècle. », Bulletin du musée basque. Hors série: Pierre et pays, 2003, pp. 89-96." Bulletin du Musée Basque Hors-Série: Pierre et Pays (December 31, 2003): 89–96. https://doi.org/10.5281/zenodo.2544212.

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Appuyée sur des archives variées, cette brève contribution à une histoire de la pierre de Bidache insiste sur les formes de sa consommation: emploi dans l'architecture, usages artisanaux. Par certaines de ses utilisations, cette pierre, dont les marchands identifient plusieurs variétés, participe avec plus ou moins de force à un complexe jeu de distinction sociale. Nous concentrerons nos observations sur la pierre qui s'extrait non loin de la Bidouze (en laissant de côté le calcaire du coniacien, dit de "Bidache",

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Contreras, Carlos Andrés, Samuel Yniesta, Abtin Jahanbakhshzadeh, and Michel Aubertin. "Correction: calibration of the PM4Sand model for hard-rock mine tailings based on laboratory and field testing results." Canadian Geotechnical Journal, October 12, 2023. http://dx.doi.org/10.1139/cgj-2023-0509.

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Résumé Une campagne d“essais en laboratoire et sur le terrain a été réalisée pour caractériser le comportement des résidus miniers de roche dure. Des essais cycliques triaxiaux, de cisaillement direct simple et de cisaillement simple triaxial ont montré que les résidus contractants sont susceptibles de se liquéfier et que leur comportement est similaire à un sable lâche malgré leur pourcentage de fines plus élevé. Afin de modéliser le comportement des parcs à résidus dans des simulations dynamiques, la loi de comportement PM4Sand est calibré à partir de l”ensemble de données présenté ici. Cert

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Denes, Dominique. "Un lieu à l’oeuvre : « La chambre noire » de Marguerite Duras." Voix Plurielles 5, no. 1 (2008). http://dx.doi.org/10.26522/vp.v5i1.477.

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Partant du constat que chez Duras la poétique de l’espace oscille entre l’« outside » du « monde extérieur » et l’inside de « la vie matérielle » et domestique - autant de formules dont elle a fait des titres - comme elle-même se partage physiquement entre ses trois lieux de l’écrit, nous nous demanderons comment et jusqu’où ses lieux informent ses livres, et à l’inverse, comment l’écriture investit le lieu et se l’approprie. Emblématique est à cet égard la chambre des Roches noires érigée en concept de « chambre noire » de la création, cette chambre-livre avec&#x

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Saudemont, Baptiste, Alexandra Popa, Joanna Parmley, et al. "The fitness cost of mis-splicing is the main determinant of alternative splicing patterns." February 22, 2017. https://doi.org/10.5281/zenodo.321639.

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Data.zip is a compressed folder that contains data relative to alternative splicing in paramecium and in human. This data set was compiled by Baptiste Saudemont, Alexandra Popa, Joanna Parmley, Vincent Rocher, Anamaria Necsulea, Eric Meyer, and Laurent Duret, for their study entitled "The fitness cost of mis-splicing is the main determinant of alternative splicing patterns".

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Vieira, Fabrício Thiengo, and Júlio D’Auria Braga. "Caracterização de parâmetros de desempenho explosivos: ANFO e emulsão explosiva." International Seven Journal of Multidisciplinary 1, no. 1 (2023). http://dx.doi.org/10.56238/isevmjv1n2-008.

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Os explosivos mais utilizados, para fins civis, na construção e mineração são o óleo combustível de nitrato de amônio (ANFO) e as emulsões explosivas. Ambos são à base de nitrato de amônio e detonam sob a mesma reação química entre nitrato e óleo mineral, uma vez que o ANFO é composto de minúsculos grãos de nitrato poroso com óleo difuso, e a emulsão está na forma de uma fase líquida, contínua, viscosa e oleosa e a fase aquosa descontínua. O estudo de parâmetros que medem o desempenho explosivo é fundamental para compreender o comportamento da explosão. Parâmetros importantes são a velocidade

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Humby, Frances C., Myles Lewis, Patrick Durez, et al. "O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy." Rheumatology 59, Supplement_2 (2020). http://dx.doi.org/10.1093/rheumatology/keaa110.006.

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Abstract Background Biologic therapies have transformed the outlook for RA but the significant health economic impact of these therapies has highlighted the need to define predictive markers of response. Rituximab (RTX) is licensed for use following failure of csDMARDs and TNF inhibitor (TNFi) therapy. However, in this increasing therapeutically resistant cohort only 30% of patients achieve an ACR50 response. The observation in early RA that 50% of patients show low/absence of synovial B-cells prompted us to test the hypothesis that in these patients a biologic agent targeting alternative path

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Ritschl, V., T. Stamm, D. Aletaha, et al. "SAT0608-HPR EULAR POINTS TO CONSIDER FOR THE DETECTION, ASSESSMENT AND MANAGEMENT OF NON-ADHERENCE IN PEOPLE WITH RHEUMATIC AND MUSCULOSKELETAL DISEASES." January 25, 2021. https://doi.org/10.1136/annrheumdis-2020-eular.787.

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Background:Non-adherence to medication and non-pharmacological interventions precludes reaching an optimal outcome. 30 to 80% of patients with rheumatic and musculoskeletal diseases (RMDs) do not adhere to their recommended treatment regimens.Objectives:The objective of this EULAR task force was to establish recommendations/points to consider (PtC) for the detection, assessment and management of non-adherence in people with RMDs.Methods:A EULAR task force (TF) was established, and the EULAR standardised operating procedures for the development of PtCs were followed. The TF included rheumatolog

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Burmester, G. R., J. M. Alvaro-Gracia, N. Betteridge, et al. "THU0579 "EVOLVING THE MANAGEMENT OF RA" PROGRAMME: EDUCATIONAL TOOLS TO SUPPORT DAILY PRACTICE." January 25, 2021. https://doi.org/10.1136/annrheumdis-2020-eular.1219.

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Background:The eRA (evolving the management of RA) programme was initiated in Europe to provide practical educational tools that address unmet needs in the management of rheumatoid arthritis (RA). Several eRA tools – covering early access to care, management of comorbidities, treat-to-target strategies, and patient empowerment – are available to the rheumatology community. Through ongoing activities, the eRA Steering Committee (SC) identified a need for tools on non-pharmacological management of RA.Objectives:To improve accessibility to eRA tools for rheumatology professionals; to review the e

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Durez, Patrick, Eugen Feist, Ricardo Blanco, et al. "P119 The Use of Exposure-Adjusted Event Rates versus Exposure-Adjusted Incidence Rates in Adverse Event Reporting: Insights from Filgotinib Integrated Safety Data in Rheumatoid Arthritis." Rheumatology 62, Supplement_2 (2023). http://dx.doi.org/10.1093/rheumatology/kead104.160.

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Abstract Background/Aims Reporting of treatment-emergent adverse events (TEAEs) in rheumatoid arthritis (RA) clinical trials can be summarized as exposure-adjusted incidence rates (EAIRs) or exposure-adjusted event rates (EAERs). Censored EAIR (EAIR), weighing exposure up to a patient’s first event, is commonly reported; uncensored EAIR (EAIRu), using total exposure time for all patients, can also be used. For EAIR, exposure time can vary by event. In contrast to EAIR(u), the total number of events are used to calculate EAER. The three methods account for different exposures and/or multiple ev

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Walker, David, Ilias Kouris, Thorsten Holzkämper, et al. "P220 An updated safety profile of baricitinib for the treatment of RA up to 7 years." Rheumatology 59, Supplement_2 (2020). http://dx.doi.org/10.1093/rheumatology/keaa111.215.

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Abstract Background Baricitinib (BARI) is a selective inhibitor of janus kinase (JAK) 1 and JAK2, approved for the treatment of moderately to severely active rheumatoid arthritis (RA) in adults in over 50 countries. Objective: To evaluate the long-term safety of BARI in patients with RA with a specific focus on malignancies, major adverse cardiovascular events (MACE), serious infections and herpes zoster (HZ) events. Methods Data from nine completed studies (5 Phase 3, 3 Phase 2, 1 Phase 1b) and 1 long term extension (LTE) study were pooled for this analysis (data cut-off date: 13-Feb-2018). T

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