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Journal articles on the topic 'Roches salines'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Correia, João Paulo Araújo, and João Paulo Lima Santos. "AVALIAÇÃO NUMÉRICA DA INTEGRIDADE ESTRUTURAL DE REVESTIMENTO DE POÇOS DE PETRÓLEO EM ZONAS DE ALTA PRESSÃO E ALTA TEMPERATURA E ÁREAS DE ROCHAS SALINAS." HOLOS 1 (July 18, 2017): 292. http://dx.doi.org/10.15628/holos.2017.5178.

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As atividades de projeto e instalação de colunas de revestimento em poços de petróleo correspondem a elementos fundamentais para garantir a segurança e a operacionalização de campos exploratórios. Com o desafio da perfuração de poços em áreas geologicamente mais complexas, a exemplo das chamadas reservas do pré-sal e em reservatórios sujeitos à alta pressão e alta temperatura (High Pressure High Temperature - HPHT), novas variáveis de projeto devem ser consideradas. Este trabalho propõe-se a avaliar o comportamento de modelos constitutivos de rochas salinas por meios de curvas de fluências obj

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Pershina, Elisaveta V., Gaik S. Tamazyan, Alexandr S. Dolnik, Alexander G. Pinaev, Nurlan H. Sergaliev, and Evgeniy E. Andronov. "STUDYING THE STRUCTURE OF SOIL MICROBIAL COMMUNITY IN SALINE SOILS BY HIGH-THROUGHPUT PYROSEQUENCING." Ecological genetics 10, no. 2 (2012): 32–39. http://dx.doi.org/10.17816/ecogen10232-39.

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The taxonomic structure of soil microbial community was studied in six samples taken from a salt marsh along the salinity gradient and in two samples of non-saline soils using pyrosequencing method (454 Roche). The analysis allowed to identify three main ecological groups of microorganisms depending on the degree of the soil salinity. Halophylic microorganisms were mainly represented by bacteria of three phyla Firmicutes, Proteobacteria and Bacteroidetes and included much less of archaea (the Halobacteriaceae family). Within the distance of 150–200 m from the point with the highest levels of s

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BOBCO, Fabia Emanuela Rafaloski, Karin GOLDBERG, and Tatiana Pastro BARDOLA. "Modelo deposicional do Membro Ipubi (Bacia do Araripe, nordeste do Brasil) a partir da caracterização faciológica, petrográfica e isotópica dos evaporitos." Pesquisas em Geociências 44, no. 3 (2017): 431. http://dx.doi.org/10.22456/1807-9806.83267.

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As rochas evaporíticas se destacam nos estudos sedimentológicos e estratigráficos por sua associação com rochas geradoras de petróleo como rochas selantes e por seu significado paleoclimático e paleoambiental. A caracterização faciológica e petrográfica quantitativa permitiu a definição das fácies e hábitos dos evaporitos do Membro Ipubi da Bacia do Araripe, coletados em afloramentos localizados principalmente na região de Araripina, Pernambuco. Técnicas de difratometria de raios X (DRX) e microscopia eletrônica de varredura (MEV) foram utilizadas com o intuito de complementar a análise dos as

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SÁ, Carlos Dinges Marques de, Danilo dos Santos BARRETO, and Maria de Lourdes da Silva ROSA. "MINERALOGIA, GEOQUÍMICA E INCLUSÕES FLUIDAS DAS MINERALIZAÇÕES FILONIANAS HIDROTERMAIS DE FLUORITA DO STOCK MINGU, SUL DA PROVÍNCIA BORBOREMA." Geosciences = Geociências 42, no. 4 (2024): 447–65. http://dx.doi.org/10.5016/geociencias.v42i4.17582.

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Resumo - O Stock Mingu é um granito do Domínio Macururé, Sistema Orogênico Sergipano (SOS), sul da Província da Borborema. As suas mineralizações de fluorita e sulfetos de Cu e Pb foram geradas por processos hidrotermais, evidenciados pelos filões mineralizados e pela cor avermelhada das rochas graníticas que os contém. As rochas do stock são biotita monzogranitos, quartzo monzonitos e monzogranitos, os dois últimos encaixantes dos filões. A química destas rochas evidenciou afinidade com a série shoshonítica. No contacto com estes granitos encontra-se a Unidade Batalha constituída por metadolo

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Kiyaga, Charles, Youyi Fong, Christopher Okiira, et al. "HIV viral load assays when used with whole blood perform well as a diagnostic assay for infants." PLOS ONE 17, no. 6 (2022): e0268127. http://dx.doi.org/10.1371/journal.pone.0268127.

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Objective Over the past several years, only approximately 50% of HIV-exposed infants received an early infant diagnosis test within the first two months of life. While high attrition and mortality account for some of the shortcomings in identifying HIV-infected infants early and putting them on life-saving treatment, fragmented and challenging laboratory systems are an added barrier. We sought to determine the accuracy of using HIV viral load assays for infant diagnosis of HIV. Methods We enrolled 866 Ugandan infants between March–April 2018 for this study after initial laboratory diagnosis. T

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Isenberg, D., R. Furie, N. S. Jones, et al. "OP0233 EFFICACY, SAFETY, AND PHARMACODYNAMIC EFFECTS OF THE BRUTON’S TYROSINE KINASE INHIBITOR, FENEBRUTINIB (GDC-0853), IN MODERATE TO SEVERE SYSTEMIC LUPUS ERYTHEMATOSUS IN A PHASE 2 CONTROLLED STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 148.1–148. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2949.

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Background:Fenebrutinib (GDC-0853, FEN) is an oral, non-covalent, and selective inhibitor of Bruton’s tyrosine kinase (BTK) in clinical development for autoimmune diseases.Objectives:This was a randomized, placebo-controlled, multi-center study to evaluate the efficacy, safety, and pharmacodynamic effects of FEN in patients with moderate-to-severe systemic lupus erythematosus (SLE) activity.Methods:Patients who met SLICC or revised ACR SLE criteria, had ≥1 serologic marker of SLE, SLEDAI ≥8, and were on ≥1 standard of care (SOC) therapy were included; patients with renal or CNS involvement, or

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Makadzange, A. Tariro, F. Kathryn Boyd, Benjamin Chimukangara, Collen Masimirembwa, David Katzenstein, and Chiratidzo E. Ndhlovu. "A Simple Phosphate-Buffered-Saline-Based Extraction Method Improves Specificity of HIV Viral Load Monitoring Using Dried Blood Spots." Journal of Clinical Microbiology 55, no. 7 (2017): 2172–79. http://dx.doi.org/10.1128/jcm.00176-17.

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ABSTRACT Although Roche COBAS Ampliprep/COBAS TaqMan (CAP/CTM) systems are widely used in sub-Saharan Africa for early infant diagnosis of HIV from dried blood spots (DBS), viral load monitoring with this system is not practical due to nonspecific extraction of both cell-free and cell-associated viral nucleic acids. A simplified DBS extraction technique for cell-free virus elution using phosphate-buffered saline (PBS) may provide an alternative analyte for lower-cost quantitative HIV virus load (VL) testing to monitor antiretroviral therapy (ART). We evaluated the CAP/CTM v2.0 assay in 272 pai

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Quintana, Manuel, Kapil Nanwani, Charbel Maroun, et al. "Study of the Effect of Fibrinogen, Factor XIII and Recombinant Activated Factor VII in a Model of Trauma-Induced Coagulopathy." Blood 136, Supplement 1 (2020): 6–7. http://dx.doi.org/10.1182/blood-2020-142482.

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Introduction: Trauma-induced coagulopathy (TIC) is a multifactorial condition secondary to severe trauma. In TIC, early fibrinogen (FI) replacement and low dose of recombinant activated factor VII (rFVIIa) may positively impact outcome. Factor XIII (FXIII), on the other hand, may stimulate in vitro clot formation and clot stability. We hypothesized that combination of FI, rFVIIa and FXIII might normalize clot formation more effectively than the isolated use of each concentrate in a model of TIC. Aim: Evaluation of the procoagulant effect of isolated or combined use of FI, rFVIIa and FXIII in a

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Farnsworth, Christopher W., Nicole M. Logsdon, Jennifer E. Hayes, Rehan Rais, Maria A. Willrich, and Ann M. Gronowski. "Limitations of Free Light Chain Assays caused by the Matrix Effect." Journal of Applied Laboratory Medicine 5, no. 2 (2020): 311–19. http://dx.doi.org/10.1093/jalm/jfz021.

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Abstract Background Serum free light chain (FLC) assays are used clinically to measure the concentration of κ and λ FLC in patients with suspected or diagnosed plasma cell proliferative disorders. Previous studies have demonstrated a loss of linearity in low concentration ranges of these assays. We hypothesized that this result could be caused by a matrix effect. Methods Recovery studies were performed for κ and λ FLC in both serum and saline using the Freelite assay (Binding Site) on a Cobas c502 system (Roche). Samples were analyzed either at the recommended dilution or undiluted. Follow-up

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Bromberg, Jacoline, Jeanette Doorduyn, Johanna W. Baars, Gustaaf Van Imhoff, Roelien Enting, and Martin van den Bent. "Acute Painful Radiculopathy After Intrathecal Rituximab." Blood 116, no. 21 (2010): 4920. http://dx.doi.org/10.1182/blood.v116.21.4920.4920.

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Abstract Abstract 4920 Within a prospective phase II study (HOVON 80) of patients with recurrent diffuse large B-cel lymphoma in the CNS, three of 13 patients treated with intrathecal rituximab developed an acute, transient, extremely painful lumbosacral radiculopathy. All were treated with systemic R-DHAP every 4 weeks with i.v. HD-MTX on day 15 for three cycles. In addition intrathecal Rituximab was administered twice weekly via lumbar puncture starting on day -1. According to protocol the first administration consisted of 10 mg of rituximab after premedication with acetaminophen, thereafter

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C., K. MAJUMDAR. "Some Applications of Mössbauer Spectroscopy." Journal of Indian Chemical Society Vol. 63, Jan 1986 (1986): 108–12. https://doi.org/10.5281/zenodo.6254934.

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Magnetism Department, Indian Association for the Cultivation of Science, Jadavpur, Calcutta-700 032 Mössbauer spectra of iron-containing inorganic and oganometallic compounds provide important information. The products of corrosion of mild steel in dilute saline and acidic medium have been identified and the diffusion constant that gives the rate of the corrosion reaction has been measured. Iron bearing minerals of eastern India are being systematically explored for geochemical information. Radiation damage in steel with Iron has also been studied to learn about defects formed in the proc

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Morais, Reurysson Chagas de Sousa, and Inessa Racine Gomes de Araújo. "ANÁLISE ESPACIAL DA CONCENTRAÇÃO DE SÓLIDOS TOTAIS DISSOLVIDOS (STD) EM ÁGUAS SUBTERRÂNEAS DA REGIÃO NORTE DO PIAUÍ." REVISTA EQUADOR 4, no. 4 (2015): 67–80. http://dx.doi.org/10.26694/equador.v4i4.3657.

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Na região norte do estado do Piauí, nordeste do Brasil, a perfuração de poços tem sido uma alternativa ao precário sistema de abastecimento público, no entanto, a concentração de STD na água pode limitar seu uso para abastecimento. O objetivo deste trabalho foi realizar uma análise espacial da concentração de sólidos totais dissolvidos (STD) em águas subterrâneas da região norte do Piauí. Para tanto, realizou-se uma interpolação dos valores de STD registrados nos poços da região, com uso de método geoestatístico. Posteriormente, buscou-se correlacioná-los com as características geológicas da r

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Kohn, Alex, François Bry, and Alexander Manta. "Semantic Search on Unstructured Data." International Journal on Semantic Web and Information Systems 6, no. 2 (2010): 17–35. http://dx.doi.org/10.4018/jswis.2010040102.

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Studies agree that searchers are often not satisfied with the performance of current enterprise search engines. As a consequence, more scientists worldwide are actively investigating new avenues for searching to improve retrieval performance. This paper contributes to YASA (Your Adaptive Search Agent), a fully implemented and thoroughly evaluated ontology-based information retrieval system for the enterprise. A salient particularity of YASA is that large parts of the ontology are automatically filled with facts by recycling and transforming existing data. YASA offers context-based personalizat

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Meng, Fanda, Weisong Huo, Jie Lian, et al. "A tandem giant magnetoresistance assay for one-shot quantification of clinically relevant concentrations of N-terminal pro-B-type natriuretic peptide in human blood." Analytical and Bioanalytical Chemistry 413, no. 11 (2021): 2943–49. http://dx.doi.org/10.1007/s00216-021-03227-5.

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AbstractWe report a microfluidic sandwich immunoassay constructed around a dual-giant magnetoresistance (GMR) sensor array to quantify the heart failure biomarker NT-proBNP in human plasma at the clinically relevant concentration levels between 15 pg/mL and 40 ng/mL. The broad dynamic range was achieved by differential coating of two identical GMR sensors operated in tandem, and combining two standard curves. The detection limit was determined as 5 pg/mL. The assay, involving 53 plasma samples from patients with different cardiovascular diseases, was validated against the Roche Cobas e411 anal

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Adamcová, Michaela, Vladimír Geršl, Jarmila Macháčková, et al. "Troponins in Experimental Studies." Acta Medica (Hradec Kralove, Czech Republic) 45, no. 1 (2002): 29–32. http://dx.doi.org/10.14712/18059694.2019.53.

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The aim of our study was to compare the diagnostic performance of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in three groups of rabbits: 1) control (saline 1 ml/kg i.v.); 2) daunorubicin (3 mg/kg i.v.); 3) daunorubicin (3 mg/kg i.v.) + dexrazoxane (60 mg/kg i.p.). The drugs were given once a week, 10 administrations. The concentration of cTnT was measured using Elecsys Troponin T STAT Immunoassay (Roche). The concentration of cTnI was measured using AxSYM Troponin I (Abbott). The linear regression model was applied to see if there is a dependence between cTnT and cTnI. The coeffic

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Visnadi, Sandra Regina. "Briófitas de praias do Estado de São Paulo, Brasil." Acta Botanica Brasilica 18, no. 1 (2004): 91–97. http://dx.doi.org/10.1590/s0102-33062004000100008.

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O trabalho compõe-se de uma lista de briófitas, um grupo de plantas ausente em ambientes marinhos, porém ocorrente em condições arenosas e salinas e sob ação das ondas e dos ventos nas praias de Ubatuba, Bertioga e Peruíbe, no Estado de São Paulo. O material coletado encontra-se depositado nos herbários SP e HRCB. As 108 exsicatas com 67 amostras de hepáticas e 59 amostras de musgos incluem 25 famílias, 49 gêneros e 77 espécies de briófitas. Os maiores números de gêneros e espécies foram observados em Lejeuneaceae e Lejeunea, respectivamente, entre as hepáticas. O mesmo pode ser dito para Orth

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Parikh, Bijal A., Meghan A. Wallace, Broc T. McCune, Carey-Ann D. Burnham, and Neil W. Anderson. "The Effects of “Dry Swab” Incubation on SARS-CoV-2 Molecular Testing." Journal of Applied Laboratory Medicine 6, no. 5 (2021): 1281–86. http://dx.doi.org/10.1093/jalm/jfab010.

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Abstract Background Widespread testing of SARS-CoV-2 has resulted in shortages of collection devices and transport media. We evaluated the stability of flocked swabs inoculated with SARS-CoV-2-containing specimen incubated dry (i.e., without transport medium) at room temperature. Methods A pool of SARS-CoV-2 positive specimen was used to inoculate flocked swabs. Five swabs were placed immediately into universal transport media (UTM) following inoculation, and tested immediately (day 0). Fifteen of the swabs were placed into sterile 15-mL conical tubes and incubated at room temperature for 1, 2

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Adamcová, Michaela, Martin Štěrba, Ivona Klimtová, et al. "Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in Rabbits." Acta Medica (Hradec Kralove, Czech Republic) 46, no. 4 (2003): 171–74. http://dx.doi.org/10.14712/18059694.2019.28.

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Both cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are considered to be reliable biomarkers with sufficient sensitivity and specificity for cardiac injury in the majority of laboratory animals. The aim of our study was to compare the diagnostic performance of cTnT and cTnI in three groups of rabbits: 1) control (saline 1 ml/kg i.v.); 2) Salicylaldehyd Isonicotinoyl Hydrazone – SIH (50 mg/kg, once weekly, i.p.; partially dissolved in 10 % Cremophor solution); 3) 10 % Cremophor solution in water (2 ml/kg i.v.). The drugs were given once a week, 10 administrations. The concentration of

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Bhardwaj, Anish, Ying Wu, Patricia D. Hurn, Jeffrey R. Kirsch, and Richard J. Traystman. "Administration of Selective Endothelin Receptor Type a Antagonist Ro 61-1790 Does Not Improve Outcome in Focal Cerebral Ischemia in Cat." Journal of Cerebral Blood Flow & Metabolism 20, no. 3 (2000): 499–504. http://dx.doi.org/10.1097/00004647-200003000-00008.

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The authors examined the effect of selective endothelin (ET) receptor type A (ETA) antagonism on histological and functional recovery in cat at 24 hours after reversible middle cerebral artery occlusion (MCAO). A novel and specific ETA antagonist, Ro 61-1790 [5-methylpyridine-2-sulfonic acid-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-1 H-tetrazol-5-yl-pyridin-4-yl)-pyrimidin-4-ylamide sodium salt (1:2)] (Roche, Basel, Switzerland), was used at doses that produced steady-state plasma concentrations and abolished ET-induced pial arteriolar vasoconstriction. In a cranial window preparation, 8

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Huber, Johann, Petra Winter, Waldemar Gottardi, Sabine Scholl-Bürgi, Wolfgang Prokop, and Markus Nagl. "Tolerability of N-chlorotaurine in the bovine mammary gland." Journal of Dairy Research 75, no. 2 (2008): 248–56. http://dx.doi.org/10.1017/s0022029908003233.

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N-Chlorotaurine (NCT) is a promising endogenous agent for topical treatment of infections. We tested the tolerability and pharmakokinetics of NCT in the bovine mammary glands in a phase 1 study. Three concentrations of NCT in water (0·1%, 1·0%, 2·0%) were administered intramammarily in each of two cows. Into two quarters of the udder 100 ml NCT was injected into each twice daily for 5 d, while 0·9% NaCl was injected into the other two quarters in a randomized and blinded manner. Samples of milk were taken to determine the number of leucocytes and the activity of NCT, and samples of urine and b

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De la Torre-Aboki, J., I. Pitsillidou, J. Uson Jaeger, et al. "AB1362-HPR COMMON PRACTICE IN DELIVERY OF INTRA-ARTICULAR THERAPIES IN RMDS BY HEALTH PROFESSIONALS: RESULTS FROM A EUROPEAN SURVEY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1968.2–1968. http://dx.doi.org/10.1136/annrheumdis-2020-eular.96.

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Background:Intra-articular therapies (IAT) are routinely used in rheumatic and musculoskeletal diseases (RMDs); however large variability exists regarding current practice of delivery amongst health professionals.Objectives:To inquire about common practice aspects to inform the EULAR Taskforce for the IAT of arthropathies.Methods:A steering committee prepared a 160-item questionnaire based on the information needs of the Taskforce. The survey was disseminated via EULAR professional associations and social media and it was open to any health professional treating persons with RMDs, regardless o

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Ferreira, Vanderlei de Oliveira. "UNIDADES DE PAISAGEM DA BACIA DO RIO JEQUITINHONHA, EM MINAS GERAIS: SUBSÍDIOS PARA A GESTÃO DE RECURSOS HÍDRICOS." Caminhos de Geografia 12, no. 37 (2011): 239–57. http://dx.doi.org/10.14393/rcg123716456.

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A análise de aspectos fisiográficos, bióticos e antrópicos das bacias hidrográficas deve oferecer subsídios efetivos para o processo de determinação de pontos de maiores e menores restrições hídricas, limites de possíveis irreversibilidades e indicação regionalizada de alternativas de manejo. Nesse contexto, é preciso desenvolver e testar instrumentos destinados à identificação da interação entre o processo de apropriação humana do território e a base natural, em compartimentos espaciais internos às bacias. O presente texto se atém aos aspectos naturais, procurando avaliar a possibilidade de a

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Harrington, Colleen T., Elaine I. Lin, Matthew T. Olson, and James R. Eshleman. "Fundamentals of Pyrosequencing." Archives of Pathology & Laboratory Medicine 137, no. 9 (2013): 1296–303. http://dx.doi.org/10.5858/arpa.2012-0463-ra.

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Context.—DNA sequencing is critical to identifying many human genetic disorders caused by DNA mutations, including cancer. Pyrosequencing is less complex, involves fewer steps, and has a superior limit of detection compared with Sanger sequencing. The fundamental basis of pyrosequencing is that pyrophosphate is released when a deoxyribonucleotide triphosphate is added to the end of a nascent strand of DNA. Because deoxyribonucleotide triphosphates are sequentially added to the reaction and because the pyrophosphate concentration is continuously monitored, the DNA sequence can be determined. Ob

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Brambrink, Ansgar M., Armin Schneider, Holger Noga, et al. "Tolerance-Inducing Dose of 3-Nitropropionic Acid Modulates bcl-2 and bax Balance in the Rat Brain: A Potential Mechanism of Chemical Preconditioning." Journal of Cerebral Blood Flow & Metabolism 20, no. 10 (2000): 1425–36. http://dx.doi.org/10.1097/00004647-200010000-00004.

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Many studies have reported ischemia protection using various preconditioning techniques, including single dose 3-nitropropionic acid (3-NPA), a mitochondrial toxin. However, the cellular signal transduction cascades resulting in ischemic tolerance and the mechanisms involved in neuronal survival in the tolerant state still remain unclear. The current study investigated the mRNA and protein expression of the antiapoptotic bcl-2 and the proapoptotic bax, two antagonistic members of the bcl-2 gene family, in response to a single dose of 3-NPA, to global cerebral ischemia–reperfusion, and to the c

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Scherlinger, M., J. Sibilia, G. Tsokos, and J. E. Gottenberg. "AB0113 CHRONIC STIMULATION WITH SARS-COV-2 SPIKE PROTEIN DOES NOT TRIGGER AUTOIMMUNITY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1235.3–1235. http://dx.doi.org/10.1136/annrheumdis-2023-eular.984.

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BackgroundSystemic autoimmunity is a complex and multifactorial process for which underlying mechanism are unclear. Several theories have been formulated to explain the development of autoimmunity, including excessive self-immunosurveillance, danger, and antigen discontinuity. The antigen discontinuity and the self-criticality theories presume that repetitive antigen exposure leads to a dysregulated immune response. Supporting these theories, Tsumiyama and Shiozawa have shown that repetitive immunization of BALB/c mice with ovalbumin induces auto-antibodies production and a glomerulonephritis

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Orea Magaña, Haydeé, and Jimena Palacios Uribe. "Análisis del deterioro de los elementos labrados del Edificio 33 de Yaxchilán, Chiapas: un estudio representativo del intemperismo de las rocas calizas de la región del Usumacinta." Intervención 1, no. 7 (2013): 21–30. http://dx.doi.org/10.30763/intervencion.2013.7.84.

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Los dinteles y los escalones labrados del Edificio 33 de la Zona Arqueológica de Yaxchilán, Chiapas, México, han presentado, desde que inició su monitoreo sistemático por parte del área de conservación del inah, en 1989, alteraciones propias de una roca caliza en proceso de intemperismo prolongado. Sin embargo, en 2003 se hizo patente que estos elementos se estaban alterando de manera distinta de la observada hasta ese momento, ya que súbitamente sus superficies presentaban desprendimientos en forma de escamas, halos y velos blanquecinos localizados, manchas de colores y material pulverulento

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Barbhuiya, Mustafa A., Edward C. Pederson, Monica L. Straub, et al. "Automated Measurement of Plasma Cell-Free Hemoglobin Using the Hemolysis Index Check Function." Journal of Applied Laboratory Medicine 5, no. 2 (2020): 281–89. http://dx.doi.org/10.1093/jalm/jfz006.

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Abstract Background The Roche Cobas chemistry analyzer’s hemolysis index (HI) check function can directly report hemoglobin (Hb) concentrations. We aimed to validate the HI check function for the measurement of plasma cell-free Hb. Methods Plasma samples (6 μl) were taken by the analyzer and diluted in normal saline to measure the absorbance for Hb at 570 and 600 nm. Hb concentrations were calculated based on the molar extinction coefficient. Imprecision, lower limit of quantification (LLOQ), and analytical measurement range (AMR) of the assay were evaluated. The accuracy was determined by com

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Figueiredo, Ana Carolina, Márcio Rodrigues, M. Lourdes Mourelle, and André R. T. S. Araujo. "Thermal Spring Waters as an Active Ingredient in Cosmetic Formulations." Cosmetics 10, no. 1 (2023): 27. http://dx.doi.org/10.3390/cosmetics10010027.

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Background: Thermal waters have been showing different beneficial effects on the skin due to their physicochemical composition. The beneficial effect of thermal water in the treatment of some skin diseases may thus justify its use as an active ingredient in cosmetic formulations. The main objective of this work was to demonstrate the potential of incorporating thermal water as an active ingredient in cosmetic formulations. (2) Methods: A descriptive literature review was carried out by the analysis of scientific articles in PubMed and Google Scholar databases. Twelve thermal spring waters were

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Mucci, N., G. Kaiser, A. Mutto, et al. "18 TOTAL PARENTERAL NUTRITION DURING NEONATAL CARE OF THE FIRST BITRANSGENIC FEMALE BOVINE CLONE." Reproduction, Fertility and Development 24, no. 1 (2012): 120. http://dx.doi.org/10.1071/rdv24n1ab18.

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This work describes the treatment with total parenteral nutrition (TPN) of a 37-day cloned calf after suffering ruminal acidosis by ingestion of milk. Cells for SCNT were obtained by using a bicistronic vector for human lysozyme and lactoferrin. We obtained 7 embryos and 2 pregnancies. Only one fetus was born alive weighing 47 kg and it was presented to the neonatal unit of INTA showing a deep depression, diarrhoea, dehydration (10%), hyperthermia and inability to stand (Table 1). A 20-cm-length 20-Ga-diameter catheter (Arrow) was placed in the jugular vein. Blood samples from catheter and bra

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Farid, Intissar, Kamel Zouari, and Abderrahmen Kallali. "Origine de la salinité des eaux du bassin Chougafiya (Tunisie)." Revue des sciences de l’eau 25, no. 3 (2012): 255–74. http://dx.doi.org/10.7202/1013106ar.

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L’exploitation intensive des ressources en eaux souterraines du bassin Chougafiya a largement influencé le fonctionnement hydrodynamique de la nappe phréatique. Elle a provoqué une inversion du gradient hydraulique et une invasion des eaux minéralisées en provenance de la nappe du Sabkhas El Batten. Afin de mettre en évidence l’effet de cette intrusion salée sur l’hydrodynamisme de la nappe phréatique, une étude multidisciplinaire basée sur les méthodes de l’hydrogéologie et la géochimie a été menée. L’étude hydrochimique a montré que le faciès des eaux évolue entre un pôle chloruré sulfaté ca

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Nandakumar, Vijayalakshmi, Christopher Dolan, Nikola A. Baumann, and Darci R. Block. "Effect of pH on the Quantification of Body Fluid Analytes for Clinical Diagnostic Testing." American Journal of Clinical Pathology 152, Supplement_1 (2019): S10—S11. http://dx.doi.org/10.1093/ajcp/aqz112.021.

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Abstract Background Body fluid samples (BFs) with low pH have demonstrated underrecovery of enzyme activity. The aims of this study were (1) measure the frequency of abnormal pH in BFs received for clinical chemistry testing, (2) calculate recovery of analytes in BFs undergoing pH titration, and (3) investigate the mechanism of pH interference. Methods Residual BFs submitted for physician-ordered testing to the Central Clinical Laboratory (Mayo Clinic) were utilized for this study. BFs were centrifuged 10 minutes (3,200 rpm) prior to pH measurement (pH meter, Accumet X15; Fisher Scientific) an

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Isnardi, C. A., E. E. Civit De Garignani, A. García Ciccarelli, et al. "AB0214 SURVIVAL, EFFICACY AND SAFETY OF GOLIMUMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS AND SPONDYLOARTHRITIS: DATA FROM AN ARGENTINEAN COHORT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1133–34. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1399.

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Background:Golimumab is a human monoclonal antibody directed against TNFα in its soluble and transmembrane forms. It can be used subcutaneously or intravenously and has shown efficacy for use in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS).Objectives:The aim of this study was to evaluate the efficacy, safety, and cumulative survival of golimumab in patients with RA, PsA and AS from different rheumatology centers in Argentina.Methods:We performed a longitudinal study of consecutive adults with RA (ACR/EULAR 2010 criteria), PsA (CASPAR criter

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Olivas, A. D., X. M. van Wijk, and P. Angelos. "Intraoperative Fine Needle Aspiration Parathyroid Hormone Assay Can Be Used as an Alternative to Frozen Section Analysis for the Identification of Parathyroid Tissue." American Journal of Clinical Pathology 154, Supplement_1 (2020): S43—S44. http://dx.doi.org/10.1093/ajcp/aqaa161.092.

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Abstract Introduction/Objective Histologic frozen section analysis is typically used for parathyroid tissue identification during parathyroidectomy when needed, in conjunction with a rapid intraoperative plasma parathyroid hormone (PTH) assay to confirm falling levels of circulating PTH after parathyroid excision. As an alternative to frozen section consults, we hypothesize that automated analysis of intraoperative fine needle aspiration (ioFNA) tissue samples using a rapid PTH immunoassay can accurately identify parathyroid tissue and reduce the need for frozen section consults. Methods A rap

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Krischek, Jan-Ole, Hans Georg Mannherz, and Markus Napirei. "Different results despite high homology: Comparative expression of human and murine DNase1 in Pichia pastoris." PLOS One 20, no. 4 (2025): e0321094. https://doi.org/10.1371/journal.pone.0321094.

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The prolonged persistence of extracellular chromatin and DNA is a salient feature of diseases like cystic fibrosis, systemic lupus erythematosus and COVID-19 associated microangiopathy. Since deoxyribonuclease I (DNase1) is a major endonuclease involved in DNA-related waste disposal, recombinant DNase1 is an important therapeutic biologic. Recently we described the production of recombinant murine DNase1 (rmDNase1) in Pichia pastoris by employing the α-mating factor prepro signal peptide (αMF-SP) a method, which we now applied to express recombinant human DNASE1 (rhDNASE1). In addition to an i

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Rodriguez-García, S. C., R. Castellanos-Moreira, J. Uson Jaeger, E. Naredo, and L. Carmona. "THU0469 QUANTIFYING THE PLACEBO EFFECT AFTER INTRA-ARTICULAR INJECTIONS: IMPLICATIONS FOR TRIALS AND PRACTICE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 471.1–471. http://dx.doi.org/10.1136/annrheumdis-2020-eular.644.

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Background:In recent years, diverse compounds for intra-articular administration were brought into the market with a subsequent significant and heterogeneous literature production. Understanding the efficacy of intra-articular therapies (IAT) on pain implies bearing in mind the related placebo (PBO) effect. To date, most studies analyzing it were focused on the compound being administered rather than the route of administration.Objectives:We aimed at evaluating the size of the PBO effect after intra-articular injections.Methods:We conducted an overview of systematic reviews (SRs) including ran

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Tremblay, K., C. Vigneault, G. Bujold, and M. A. Sirard. "253BOVINE OOCYTE CYCLIN B1 MRNA UNDERGOES CYTOPLASMIC POLYADENYLATION BEFORE THE BEGINNING OF IN VITRO MATURATION." Reproduction, Fertility and Development 16, no. 2 (2004): 246. http://dx.doi.org/10.1071/rdv16n1ab253.

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Maternal oocyte Cyclin B1 mRNA is known to be stored in the cytoplasm with a short poly(A) tail and be translationally dormant at GV stage. During maturation, Cyclin B1 poly(A) tail is elongated by a process called cytoplasmic polyadenylation and driven by A/U-rich cis-acting elements in its 3′ untranslated region (UTR) known as cytoplasmic polyadenylation elements (CPEs). The objective of this study was to elucidate whether GV-stage bovine oocytes possess a stockpile of Cyclin B1 mRNA stored with a short a poly(A) tail that is elongated during maturation by CPE regulation. The mRNA poly(A) ta

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Bridgewater, S., J. Dawson, M. Ndosi, et al. "AB0834 DEVELOPMENT OF A CONCEPTUAL FRAMEWORK FOR A PATIENT REPORTED OUTCOME MEASURE TO CAPTURE PATIENTS’ PERCEPTIONS OF GLUCOCORTICOID THERAPY DURING TREATMENT FOR RHEUMATIC DISEASES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1441.1–1441. http://dx.doi.org/10.1136/annrheumdis-2021-eular.164.

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Background:Glucocorticoids (GCs) are a key treatment for the autoimmune rheumatic diseases; however, they produce numerous physical and psychological side effects.1 The Outcome Measures in Rheumatology (OMERACT) Glucocorticoid Working Group have identified that there are no Patient Reported Outcome Measures (PROMs) for assessing the impact of systemic GC therapy across multiple rheumatic diseases from the patient’s perspective.2,3Objectives:The aim is to explore the impact of GCs on the symptoms and health-related quality of life of adults with rheumatic inflammatory diseases, to inform items

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Armand, Philippe, Pier Luigi Luigi Zinzani, Hun Ju Lee, et al. "Five-Year Follow-up of Keynote-087: Pembrolizumab Monotherapy in Relapsed/Refractory Classical Hodgkin Lymphoma (R/R cHL)." Blood 138, Supplement 1 (2021): 1366. http://dx.doi.org/10.1182/blood-2021-147881.

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Abstract Introduction: Prognosis remains poor for patients (pts) with R/R cHL who relapse after or are ineligible for autologous stem cell transplant (ASCT). Programmed death 1 (PD-1) inhibitors are an effective therapeutic option for such pts. Previous analyses from the phase 2 KEYNOTE-087 (NCT02453594) trial demonstrated that monotherapy with the PD-1 inhibitor pembrolizumab (pembro) had effective antitumor activity and acceptable safety in pts with R/R cHL, leading to FDA approval for adult and pediatric pts with R/R cHL who relapsed after ≥3 prior lines of therapy. However, durability of r

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Fratoni, Andrew J., David P. Nicolau, and Joseph L. Kuti. "65. In Vivo Efficacy of Human Simulated Minocycline (MIN) against Stenotrophomonas maltophilia (STM)." Open Forum Infectious Diseases 8, Supplement_1 (2021): S44. http://dx.doi.org/10.1093/ofid/ofab466.065.

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Abstract Background The current susceptibility breakpoint for MIN against STM is 4mg/L, yielding &gt;99% of isolates susceptible. Unfortunately, there are limited pre-clinical and clinical data to support this breakpoint for STM. The purpose of this study was to evaluate the efficacy of a MIN human simulated regimen (HSR) against STM across a wide range of MICs in the murine neutropenic thigh model. Methods Clinical STM with modal MIN MICS of 0.25-8mg/L were included. Confirmatory pharmacokinetic (PK) studies were performed in infected neutropenic mice to develop a MIN HSR providing an are

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Roeker, Lindsey E., Christopher P. Fox, Toby A. Eyre, et al. "Adverse Events, Patterns of Tumor Lysis Syndrome Prophylaxis and Management, and Dosing Patterns in a Large Cohort of Venetoclax Treated CLL Patients in Community and Academic Settings." Blood 132, Supplement 1 (2018): 4410. http://dx.doi.org/10.1182/blood-2018-99-118159.

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Abstract Introduction: Venetoclax (Ven), an oral BCL2 inhibitor, is approved for the treatment (tx) of relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL). Ven is generally well tolerated, and side effects observed in clinical trials have been consistent with other CLL tx. Clinical trials using the approved dose escalation schedule report negligible rates of clinical tumor lysis syndrome (TLS). We aimed to understand rates of select adverse events (AEs) including cytopenias, infections, and TLS in CLL patients (pts) treated with Ven in community and academic settings. To do so, we exa

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Nachawi, Noura, Stephania Paredes, Stephen Seibert, Adam McShane, and Kevin M. Pantalone. "Extreme Secretion of PTHrP From a Pancreatic Neuroendocrine Tumor, A Shift From Severe Hypercalcemia to Hypocalcemia." Journal of the Endocrine Society 5, Supplement_1 (2021): A192—A193. http://dx.doi.org/10.1210/jendso/bvab048.391.

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Abstract Background: PTHrP-secreting pancreatic neuroendocrine tumors (PNET) are a recognized cause of malignancy associated hypercalcemia. Herein, we report a case of severe hypercalcemia due to an extreme elevation of PTHrP from a PNET, where after treatment of the hypercalcemia, symptomatic hypocalcemia occurred. Clinical Case: A 59 year-old-woman with a recurrent PNET with liver metastases undergoing an evaluation for multi-visceral transplant presented with acute confusion, nausea and vomiting. Diagnostic testing identified an extreme elevation of total calcium (Ca) [&gt;20.1 mg/dL (8

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Saadalla, Abdulrahman, Brooke Stroup, and Bijal Parikh. "VariantDirect: An extraction-free screening approach to detect circulating SARS-CoV-2 virus strains from pooled specimens." American Journal of Clinical Pathology 156, Supplement_1 (2021): S19—S20. http://dx.doi.org/10.1093/ajcp/aqab189.036.

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Abstract Coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus has exposed clinical laboratories to unprecedented challenges. With surging case numbers, clinical laboratories were forced to acquiesce and integrate multiple testing platforms with varying workflows and analytical sensitivities in order to meet testing volumes. Now a new challenge has emerged with the evolution of viral variants, both globally and locally, raising concerns for uncontrolled spread, increased disease severity, and weakened responses to vaccinations. Preliminary data suggests that these variants may be assoc

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Rodriguez, A., L. J. Royo, F. Goyache, et al. "249BOVINE GRANULOSA CELLS MRNA EXPRESSION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-± AND THE PROTO-ONCOGENE C-FOS." Reproduction, Fertility and Development 16, no. 2 (2004): 245. http://dx.doi.org/10.1071/rdv16n1ab249.

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PPARα and c-Fos are involved in regulation of gene expression and are known to be dependent on retinoic acid (RA), which in turn influences oocyte growth and developmental competence (Duque et al., 2002 Hum. Reprod. 17, 2706–2714; Hidalgo et al., 2003. Reproduction 125, 409–416), probably acting in part through granulosa cells. Peroxisome proliferator-activated receptor-α (PPARα) heterodimerizes with the retinoid receptor X (RXR), while c-Jun/c-Fos heterodimerizes with liganded retinoic acid receptors (RARs), then preventing formation of transcription factor activator protein 1 (AP-1) complexe

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Choucair, Ibrahim, Michael Vera, Edward Lee, Joe El-Khoury, and Thomas Durant. "Detecting Exogenous Contamination of Clinical Blood Samples with Crystalloid Solutions: A Data Driven Approach to Derive and Validate Delta Checks." American Journal of Clinical Pathology 158, Supplement_1 (2022): S3. http://dx.doi.org/10.1093/ajcp/aqac126.004.

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Abstract Pre-analytical error may occur when collecting blood samples from intravenous (IV) lines. Blood samples can be inadvertently diluted by exogenous solutions if an insufficient amount of blood is discarded prior to collection. Rules built in the laboratory information system or middleware can be used to alert laboratory staff to specimens that require co-investigation with the clinical team to determine if sample dilution is possible or likely. Currently, however, there is a lack of literature to guide laboratorians on how to define quality rules of this nature, particularly for detecti

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Pinzon, E., and L. Higuera. "POS0986-PARE IMPACT OF EDUCATIONAL CAMPAIGNS ON RMD IN SOCIAL NETWORKS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 809.2–810. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5843.

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BackgroundPanama’s prevalence of rheumatoid arthritis lies within the global range (.24 to 1%). To improve the quality of life of RMD patients in the country, FUNARP was created over 18 years ago to educate and support patients, caregivers, and civil.FUNARP decided to focus its efforts on digital campaigns since 2020 taking advantage of its coverage, low costs, and ease of usage. Further, the mobile penetration of Panama is 136% of its population [1] making social media the best distribution channel for this purpose.ObjectivesTo expand educational coverage, especially for those with limited mo

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Nino-Soto, M., G. Mastromonaco, P. Blondin, and W. A. King. "64 X-LINKED GENE EXPRESSION IN BOVINE (BOS TAURUS) MALE AND FEMALE IN VITRO- FERTILIZED AND SOMATIC CELL NUCLEAR TRANSFER-DERIVED BLASTOCYSTS." Reproduction, Fertility and Development 18, no. 2 (2006): 140. http://dx.doi.org/10.1071/rdv18n2ab64.

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Expression of some X-chromosome linked genes has recently been shown to be altered in bovine somatic cell nuclear transfer (SCNT) derived embryos (Wrenzycki et al. 2002 Biol. Reprod. 66, 127), implying that the regulatory mechanisms of X-linked transcription are affected by embryo in vitro production (IVP) methods. We analyzed the transcriptional pattern of X-linked genes (BIRC4, GAB3, HPRT1, MECP2, RPS4X, SLC25A6, and XIST) in bovine in vitro fertilized (IVF) and SCNT male and female blastocysts to determine X-inactivation status and changes resulting from IVP. We collected pools of male (n =

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De Chico, P. L. M., E. C. S. Recalde, T. L. Ikeda, M. J. Sudano, and F. Landim-Alvarenga. "170 IN VITRO EMBRYO PRODUCTION AND APOPTOSIS DETECTION USING BOVINE OOCYTES MATURED WITH IGF-I OR IGF-LongR3." Reproduction, Fertility and Development 28, no. 2 (2016): 215. http://dx.doi.org/10.1071/rdv28n2ab170.

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The aim of this study was to compare the differential effects of the addition of IGF-LongR3 or insulin-like growth factor-1 (IGF-1), during in vitro maturation (IVM) of bovine oocytes on embryonic development, by analysing embryonic viability and apoptosis. Ovaries collected at a slaughterhouse were transported in saline solution (NaCl 0.9%) at 38°C. Follicles of 2–8 mm of diameter were aspirated. Only cumulus-oocyte complexes (COC) with homogeneous cytoplasm, surrounded by at least 3 layers of compact cumulus cells were selected in Dulbecco’ modified PBS 0.3% polyvinyl alcohol (PVA) and trans

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Farinon, M., R. T. Pedo, T. Hein Da Rosa, et al. "THU0074 ANTI-ARTHRITIC EFFECT OF RECOMBINANT CYSTATIN 3 FROM FASCIOLA HEPATICA IN COLLAGEN-INDUCED ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 250.2–250. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5097.

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Background:Cystatins are cysteine proteases-inhibitors secreted byFasciola hepaticain order to modulate the host immune response to promote survival of the parasite. These molecules are able to inhibit different mammal cathepsins, to regulate the immune balance via Th2 and T regulatory responses, to downregulate antigen presentation and the release of pro-inflammatory cytokines (1,2) – mechanisms that are important in the development and maintenance of several immunopathology, as rheumatoid arthritis (RA) (3).Objectives:To evaluate the therapeutic effect of recombinants cystatin 1 and cystatin

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Rossi, Edmund A., William J. McBride, Diane L. Nordstrom та ін. "A New Class of Dimeric α-Interferons (IFN-α) Made by the Dock and Lock (DNL) Method for Improved Cancer Therapy." Blood 110, № 11 (2007): 1396. http://dx.doi.org/10.1182/blood.v110.11.1396.1396.

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Abstract Background: IFN-α2 is indicated for the therapy of hairy cell leukemia, chronic myelogenous leukemia, follicular lymphoma, and malignant melanoma. As is the case for most cytokines, the pharmacokinetic (PK) properties of IFN-α2 are critical for dosing and efficacy. In vivo, the protein is quickly degraded, diffuses widely throughout the body, and has a rapid rate of renal clearance. Pegylation of IFN-α2 significantly increases the serum half-life and reduces renal clearance, thus enhancing its efficacy. However, established pegylation of IFN-α2 results in a mixture of positional isome

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Khanna, Amardeep, Laura Jopson, Denise Howel, et al. "Rituximab for the treatment of fatigue in primary biliary cholangitis (formerly primary biliary cirrhosis): a randomised controlled trial." Efficacy and Mechanism Evaluation 5, no. 2 (2018): 1–78. http://dx.doi.org/10.3310/eme05020.

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Background Primary biliary cirrhosis (PBC) is an autoimmune liver disease, and 50% of patients with this disease experience fatigue. This is a debilitating symptom affecting quality of life and resulting in social isolation, which is highlighted by patients as a research priority. PBC is characterised immunologically by the presence of high-titre autoantibodies that are directed at the pyruvate dehydrogenase complex (PDC) and are highly effective at blocking its energy generation function. We hypothesised that if anti-PDC antibodies were a driver of fatigue through bioenergetic dysfunction, th

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