Academic literature on the topic 'Rocking bioreactor'

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Journal articles on the topic "Rocking bioreactor"

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Ramirez-Malule, Howard, Víctor A. López-Agudelo, David Gómez-Ríos, et al. "TCA Cycle and Its Relationship with Clavulanic Acid Production: A Further Interpretation by Using a Reduced Genome-Scale Metabolic Model of Streptomyces clavuligerus." Bioengineering 8, no. 8 (2021): 103. http://dx.doi.org/10.3390/bioengineering8080103.

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Streptomyces clavuligerus (S. clavuligerus) has been widely studied for its ability to produce clavulanic acid (CA), a potent inhibitor of β-lactamase enzymes. In this study, S. clavuligerus cultivated in 2D rocking bioreactor in fed-batch operation produced CA at comparable rates to those observed in stirred tank bioreactors. A reduced model of S. clavuligerus metabolism was constructed by using a bottom-up approach and validated using experimental data. The reduced model was implemented for in silico studies of the metabolic scenarios arisen during the cultivations. Constraint-based analysis
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Vera, Juan F., Lara Brenner, Ann M. Leen, et al. "Rapid Generation of Antigen-Specific T Cells for Pre-Clinical and Clinical Applications Using a Novel Mini Cell Bioreactor." Blood 112, no. 11 (2008): 208. http://dx.doi.org/10.1182/blood.v112.11.208.208.

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Abstract Although flasks, bags, or rocking bioreactors can readily expand T lymphocytes after non-specific stimulation, the requirements for antigen-driven expansion of cytotoxic T lymphocytes (CTLs) are more rigorous. Antigen-specific T cells proliferate optimally only in the 2 mL wells of 24-well plates and cannot reproducibly be adapted to growth in flasks or bags. Hence, preparation of antigen-specific T cells for adoptive immunotherapy of malignancies is extremely time-consuming, requiring between 4wks and 3mths to produce sufficient cells for therapeutic purposes, and expensive (media +
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Bai, Yun, Murray Moo‐Young, and William A. Anderson. "A mechanistic model for gas–liquid mass transfer prediction in a rocking disposable bioreactor." Biotechnology and Bioengineering 116, no. 8 (2019): 1986–98. http://dx.doi.org/10.1002/bit.27000.

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Davis, Brian M., Evelina R. Loghin, Kenneth R. Conway, and Xiaohua Zhang. "Automated Closed-System Expansion of Pluripotent Stem Cell Aggregates in a Rocking-Motion Bioreactor." SLAS TECHNOLOGY: Translating Life Sciences Innovation 23, no. 4 (2018): 364–73. http://dx.doi.org/10.1177/2472630318760745.

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Sauvage, V., M. Janas, S. Stone, A. Marenghi, S. Stubbs, and B. Mark. "Optimization of the rocking speed and angle of a perfusion bioreactor for T cell culture." Cytotherapy 16, no. 4 (2014): S35. http://dx.doi.org/10.1016/j.jcyt.2014.01.117.

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Westbrook, Adam, Jeno Scharer, Murray Moo-Young, Nico Oosterhuis, and C. Perry Chou. "Application of a two-dimensional disposable rocking bioreactor to bacterial cultivation for recombinant protein production." Biochemical Engineering Journal 88 (July 2014): 154–61. http://dx.doi.org/10.1016/j.bej.2014.04.011.

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Bai, Yun, Murray Moo-Young, and William A. Anderson. "Characterization of power input and its impact on mass transfer in a rocking disposable bioreactor." Chemical Engineering Science 209 (December 2019): 115183. http://dx.doi.org/10.1016/j.ces.2019.115183.

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Gratch, Y. S., P. Bowles, R. Krishnan, S. Loo-Yong-Kee, R. K. Iyer, and A. Dulgar-Tulloch. "A semi-automated, high-purity process for natural killer (NK) cell manufacturing in a rocking bioreactor." Cytotherapy 20, no. 5 (2018): e8-e9. http://dx.doi.org/10.1016/j.jcyt.2018.03.029.

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Glazyrina, Julia, Eva-Maria Materne, Thomas Dreher, et al. "High cell density cultivation and recombinant protein production with Escherichia coli in a rocking-motion-type bioreactor." Microbial Cell Factories 9, no. 1 (2010): 42. http://dx.doi.org/10.1186/1475-2859-9-42.

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Cirés, Samuel, Carlos Alvarez-Roa, and Kirsten Heimann. "First use of the WAVE™ disposable rocking bioreactor for enhanced bioproduct synthesis by N2-fixing cyanobacteria." Biotechnology and Bioengineering 112, no. 3 (2014): 621–26. http://dx.doi.org/10.1002/bit.25455.

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Dissertations / Theses on the topic "Rocking bioreactor"

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Westbrook, Adam. "Disposable rocking bioreactors for recombinant protein production in Escherichia coli: Physical characterization and assessment of therapeutic protein expression." Thesis, 2013. http://hdl.handle.net/10012/7927.

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Disposable technology has gained increasing acceptance in the biopharmaceutical industry over the last decade, and provides many advantages over conventional stainless steel equipment. Disposable rocking bioreactors (RBs) are widely employed for cultivation of recombinant mammalian and insect cell lines, although the perception of inadequate mass transfer has prevented their application to bioprocesses based on microbial platforms. In an effort to thoroughly evaluate the suitability of disposable RBs for cultivation of aerobic microorganisms, a comparative study of one-dimensional (1D) and two
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Book chapters on the topic "Rocking bioreactor"

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Oosterhuis, Nico M. G. "Perfusion Process Design in a 2D Rocking Single-Use Bioreactor." In Continuous Processing in Pharmaceutical Manufacturing. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527673681.ch07.

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Conference papers on the topic "Rocking bioreactor"

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"Adaptation of the sensor method for the determination of mixing time in a rocking single-use bioreactor." In Chemical technology and engineering. Lviv Polytechnic National University, 2021. http://dx.doi.org/10.23939/cte2021.01.166.

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