Log in

Relevant bibliographies by topics / Rooibos, adrenal steroidogenic enzymes / Journal articles

To see the other types of publications on this topic, follow the link: Rooibos, adrenal steroidogenic enzymes.

Journal articles on the topic 'Rooibos, adrenal steroidogenic enzymes'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Rooibos, adrenal steroidogenic enzymes.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Schloms, Lindie, and Amanda Swart. "Rooibos Flavonoids Inhibit the Activity of Key Adrenal Steroidogenic Enzymes, Modulating Steroid Hormone Levels in H295R Cells." Molecules 19, no. 3 (2014): 3681–95. http://dx.doi.org/10.3390/molecules19033681.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Baranowski, Elizabeth S., Wiebke Arlt, and Jan Idkowiak. "Monogenic Disorders of Adrenal Steroidogenesis." Hormone Research in Paediatrics 89, no. 5 (2018): 292–310. http://dx.doi.org/10.1159/000488034.

Full text

Abstract:

Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches of the steroidogenic machinery involved in the production of mineralocorticoids, glucocorticoids, and androgens. This mini review describes the principles of adrenal steroidogenesis, including the newly appreciated 11-oxygenated androgen pathway. This is followed by a description of pathophysiology, biochemistry, and clinical implications of steroidogenic disorders, including mutations affecting cholesterol import and

APA, Harvard, Vancouver, ISO, and other styles

3

Parker, Keith L., and Bernard P. Schimmer. "Transcriptional regulation of the adrenal steroidogenic enzymes." Trends in Endocrinology & Metabolism 4, no. 2 (1993): 46–50. http://dx.doi.org/10.1016/s1043-2760(05)80014-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Provencher, P. H., Y. Tremblay, B. Belanger, and A. Belanger. "Studies of adrenal steroidogenic enzymes in guinea pigs." American Journal of Physiology-Endocrinology and Metabolism 262, no. 6 (1992): E869—E874. http://dx.doi.org/10.1152/ajpendo.1992.262.6.e869.

Full text

Abstract:

In the present study we found that 3 beta-hydroxysteroid dehydrogenase 4-ene-5-ene-isomerase (3 beta-HSD), 17-hydroxylase and 17,20-lyase (P-450c17), and 21-hydroxylase (P-450c21) activities in a suspension of cells from guinea pig zona reticularis (RE) were 10- to 15-fold less than those measured in cells from zona fasciculata-glomerulosa (FG). Whereas the secretion of cortisol and C-19 steroids was remarkably increased during treatment of FG cells with adrenocorticotropic hormone (ACTH), no response could be detected when using cells from zona RE. By contrast, the measurement of a series of

APA, Harvard, Vancouver, ISO, and other styles

5

Ross, J. T., I. C. McMillen, F. Lok, A. G. Thiel, J. A. Owens, and C. L. Coulter. "Intrafetal Insulin-Like Growth Factor-I Infusion Stimulates Adrenal Growth But Not Steroidogenesis in the Sheep Fetus during Late Gestation." Endocrinology 148, no. 11 (2007): 5424–32. http://dx.doi.org/10.1210/en.2006-1573.

Full text

Abstract:

We investigated the effects of an intrafetal infusion of IGF-I on adrenal growth and expression of the adrenal steroidogenic and catecholamine-synthetic enzyme mRNAs in the sheep fetus during late gestation. Fetal sheep were infused for 10 d with either IGF-I (26 μg/kg·h; n = 14) or saline (n = 10) between 120 and 130 d gestation, and adrenal glands were collected for morphological analysis and determination of the mRNA expression of steroidogenic and catecholamine-synthetic enzymes. Fetal body weight was not altered by IGF-I infusion; however, adrenal weight was significantly increased by 145

APA, Harvard, Vancouver, ISO, and other styles

6

Khorram, Naseem M., Thomas R. Magee, Chen Wang, Mina Desai, Michael Ross, and Omid Khorram. "Maternal Undernutrition Programs Offspring Adrenal Expression of Steroidogenic Enzymes." Reproductive Sciences 18, no. 10 (2011): 931–40. http://dx.doi.org/10.1177/1933719111404613.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Lundqvist, Johan. "Vitamin D as a regulator of steroidogenic enzymes." F1000Research 3 (July 8, 2014): 155. http://dx.doi.org/10.12688/f1000research.4714.1.

Full text

Abstract:

During the last decades, the outlook on vitamin D has widened, from being a vitamin solely involved in bone metabolism and calcium homeostasis, to being a multifunctional hormone known to affect a broad range of physiological processes. The aim of this review is to summarize the research on vitamin D as a regulator of steroidogenic enzymes. Steroid hormones exert a wide range of physiological responses, including functions in the immune system, protein and carbohydrate metabolism, water and salt balance, reproductive system and development of sexual characteristics. The balance of sex hormones

APA, Harvard, Vancouver, ISO, and other styles

8

Saito, Ryuta, Natsuko Terasaki, Makoto Yamazaki, Naoya Masutomi, Naohisa Tsutsui, and Masahiro Okamoto. "Estimation of the Mechanism of Adrenal Action of Endocrine-Disrupting Compounds Using a Computational Model of Adrenal Steroidogenesis in NCI-H295R Cells." Journal of Toxicology 2016 (2016): 1–19. http://dx.doi.org/10.1155/2016/4041827.

Full text

Abstract:

Adrenal toxicity is one of the major concerns in drug development. To quantitatively understand the effect of endocrine-active compounds on adrenal steroidogenesis and to assess the human adrenal toxicity of novel pharmaceutical drugs, we developed a mathematical model of steroidogenesis in human adrenocortical carcinoma NCI-H295R cells. The model includes cellular proliferation, intracellular cholesterol translocation, diffusional transport of steroids, and metabolic pathways of adrenal steroidogenesis, which serially involve steroidogenic proteins and enzymes such as StAR, CYP11A1, CYP17A1,

APA, Harvard, Vancouver, ISO, and other styles

9

Shibata, Hirotaka, Hiromichi Suzuki, Tadashi Ogishima, Yuzuru Ishimura, and Takao Saruta. "Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour." Acta Endocrinologica 128, no. 3 (1993): 235–42. http://dx.doi.org/10.1530/acta.0.1280235.

Full text

Abstract:

We examined both activities and amounts of steroidogenic cytochrome P-450s at the posttranslational protein level and steroid contents in the adrenocortical adenoma from patients with primary aldosteronism and Cushing's syndrome. Aldosterone synthase cytochrome P-450 (human P-450aldo) was detected in the tumour portion of aldosterone-producing adenoma, but not in the normal control adrenals, at the protein level. Neither the activities nor the amounts of other P-450s in the tumour portion of aldosterone-producing adenoma were significantly different from those in the non-tumour portion in the

APA, Harvard, Vancouver, ISO, and other styles

10

LeHoux, J. G., J. I. Mason, and L. Ducharme. "In vivo effects of adrenocorticotropin on hamster adrenal steroidogenic enzymes." Endocrinology 131, no. 4 (1992): 1874–82. http://dx.doi.org/10.1210/endo.131.4.1327721.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

SASANO, HIRONOBU. "Localization of Steroidogenic Enzymes in Adrenal Cortex and Its Disorders." Endocrine Journal 41, no. 5 (1994): 471–82. http://dx.doi.org/10.1507/endocrj.41.471.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Schimmer, Bernard P. "The 1994 Upjohn Award Lecture. Molecular and genetic approaches to the study of signal transduction in the adrenal cortex." Canadian Journal of Physiology and Pharmacology 73, no. 8 (1995): 1097–107. http://dx.doi.org/10.1139/y95-157.

Full text

Abstract:

This review highlights contributions from my laboratory in which the sites and mechanisms of action of the adrenocorticotropic hormone (ACTH) in the adrenal cortex have been explored. Early studies showing that ACTH stimulates adrenal steroidogenesis by interacting with specific receptors at the cell surface are summarized. Next, the development of a strategy of genetic analysis to define the signalling events that follow ACTH interaction with its receptor is described. This strategy involved the isolation and characterization of mutant adrenal cell lines harboring specific defects in the ACTH

APA, Harvard, Vancouver, ISO, and other styles

13

Melau, Cecilie, John Erik Nielsen, Hanne Frederiksen, et al. "Characterization of Human Adrenal Steroidogenesis During Fetal Development." Journal of Clinical Endocrinology & Metabolism 104, no. 5 (2018): 1802–12. http://dx.doi.org/10.1210/jc.2018-01759.

Full text

Abstract:

Abstract Context The endocrine function of human fetal adrenals (HFAs) is activated already during first trimester, but adrenal steroidogenesis during fetal life is not well characterized. Objective This study aimed to investigate HFA steroidogenesis by analyzing adrenal glands from first and second trimesters. Design and Setting Male and female HFA from gestational weeks (GWs) 8 to 19 were examined, including a total of 101 samples from 83 fetuses. Main Outcome Measure(s) Expression level of steroidogenic genes and protein expression/localization were determined by quantitative PCR and immuno

APA, Harvard, Vancouver, ISO, and other styles

14

SUZUKI, HIROMIGHI, HIROTAKA SHIBATA, TAKASHI TAKITA, et al. "Steroid Contents and Cortical Steroidogenic Enzymes in Non-Hyperfunctioning Adrenal Adenoma." Endocrine Journal 41, no. 3 (1994): 267–74. http://dx.doi.org/10.1507/endocrj.41.267.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Prevoo, Désirée, Pieter Swart, and Amanda C. Swart. "The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes." Journal of Ethnopharmacology 118, no. 1 (2008): 118–26. http://dx.doi.org/10.1016/j.jep.2008.03.019.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Tetsi Nomigni, Milène, Sophie Ouzounian, Alice Benoit, et al. "Steroidogenic enzyme profile in an androgen-secreting adrenocortical oncocytoma associated with hirsustism." Endocrine Connections 4, no. 2 (2015): 117–27. http://dx.doi.org/10.1530/ec-15-0014.

Full text

Abstract:

Hirsutism induced by hyperandrogenism can be associated with polycystic ovary syndrome, 21-hydroxylase (OH) deficiency or androgen-secreting tumors, including ovarian and adrenal tumors. Adrenal androgen-secreting tumors are frequently malignant. Adrenal oncocytomas represent rare causes of hyperandrogenism. The aim of the study was to investigate steroidogenic enzyme expression and steroid secretion in an androgen-secreting adrenal oncocytoma in a young woman presenting with hirsutism. Hyperandrogenism was diagnosed on the basis of elevated plasma Δ4-androstenedione and testosterone levels. P

APA, Harvard, Vancouver, ISO, and other styles

17

Lottrup, Grete, John E. Nielsen, Niels E. Skakkebæk, Anders Juul, and Ewa Rajpert-De Meyts. "Abundance of DLK1, differential expression of CYP11B1, CYP21A2 and MC2R, and lack of INSL3 distinguish testicular adrenal rest tumours from Leydig cell tumours." European Journal of Endocrinology 172, no. 4 (2015): 491–99. http://dx.doi.org/10.1530/eje-14-0810.

Full text

Abstract:

ObjectiveTesticular adrenal rest tumours (TARTs) are a common finding in patients with congenital adrenal hyperplasia (CAH). These tumours constitute a diagnostic and management conundrum and may lead to infertility. TART cells share many functional and morphological similarities with Leydig cells (LCs), and masses consisting of such cells are occasionally misclassified as malignant testicular tumours, which may lead to erroneous orchiectomy in these patients.DesignIn this study, we aimed to investigate the potential of LC developmental markers and adrenal steroidogenic markers in the differen

APA, Harvard, Vancouver, ISO, and other styles

18

Provencher, P. H., Y. Tremblay, and A. Bélanger. "Effects of C19 steroids on adrenal steroidogenic enzyme activities and their mRNA levels in guinea-pig fasciculata-glomerulosa cells in primary culture." Journal of Endocrinology 132, no. 2 (1992): 269–76. http://dx.doi.org/10.1677/joe.0.1320269.

Full text

Abstract:

ABSTRACT The present study examined the effects of steroids on steroidogenic enzyme activity in adrenal glands. Guinea-pig fasciculata-glomerulosa (FG) cells maintained in primary culture were exposed to steroids for 48 h. Although the treatment with androstenedione alone had no effect on 3β-hydroxysteroid dehydrogenase 4-ene-5-ene-isomerase (3β-HSD), 17-hydroxylase and 17,20-lyase activities, there was inhibition of 11-hydroxylase and 21-hydroxylase activities. When FG cells were exposed to 10 nmol ACTH/l for the last 24 h of incubation, ACTH alone had no effect on steroidogenic enzymes but,

APA, Harvard, Vancouver, ISO, and other styles

19

Hierlihy, Andrée M., Gerard M. Cooke, Ivan H. A. Curran, Rekha Mehta, Litsa Karamanos, and Christopher A. Price. "Effects of ciprofibrate on testicular and adrenal steroidogenic enzymes in the rat." Reproductive Toxicology 22, no. 1 (2006): 37–43. http://dx.doi.org/10.1016/j.reprotox.2005.11.001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Suzuki, Takashi, Hironobu Sasano, Junji Takeyama, et al. "Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies." Clinical Endocrinology 53, no. 6 (2000): 739–47. http://dx.doi.org/10.1046/j.1365-2265.2000.01144.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Ishimura, Kazunori, and Hisao Fujita. "Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes." Microscopy Research and Technique 36, no. 6 (1997): 445–53. http://dx.doi.org/10.1002/(sici)1097-0029(19970315)36:6<445::aid-jemt2>3.0.co;2-h.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Mellon, Synthia H., and Christian F. Deschepper. "Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain." Brain Research 629, no. 2 (1993): 283–92. http://dx.doi.org/10.1016/0006-8993(93)91332-m.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Riester, Anna, Ariadni Spyroglou, Adi Neufeld-Cohen, Alon Chen, and Felix Beuschlein. "Urocortin-dependent effects on adrenal morphology, growth, and expression of steroidogenic enzymes in vivo." Journal of Molecular Endocrinology 48, no. 2 (2012): 159–67. http://dx.doi.org/10.1530/jme-11-0144.

Full text

Abstract:

Urocortin (UCN) 1, 2, and 3 are members of the corticotropin-releasing factor (CRF) family that display varying affinities to the CRF receptor 1 (CRFR1 (CRHR1)) and 2 (CRFR2 (CRHR2)). UCNs represent important modulators of stress responses and are involved in the control of anxiety and related disorders. In addition to the CNS, UCNs and CRFRs are highly expressed in several tissues including the adrenal gland, indicating the presence of UCN-dependent regulatory mechanisms in these peripheral organ systems. Using knockout (KO) mouse models lacking single or multipleUcngenes, we examined the pot

APA, Harvard, Vancouver, ISO, and other styles

24

Shigematsu, Kazuto, Takehiro Nakagaki, Naohiro Yamaguchi, Kioko Kawai, Hideki Sakai, and Osamu Takahara. "Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas." European Journal of Endocrinology 158, no. 6 (2008): 867–78. http://dx.doi.org/10.1530/eje-07-0626.

Full text

Abstract:

Design and methodsWe have recently demonstrated that the adrenal cortices attached to aldosterone-producing adenoma (APA) contained microscopic subcapsular micronodules suggestive of active aldosterone production. In this study, we used in situ hybridization to investigate the mRNA expression of steroidogenic enzymes in the adrenal cortices attached to cortisol-producing adenoma (CPA) and clinically silent adenoma (non-functioning adenoma; NFA), in addition to APA.ResultsMicroscopic subcapsular micronodules, which were several hundreds of micrometers in size and spheroid in shape, were observe

APA, Harvard, Vancouver, ISO, and other styles

25

Provencher, P. H., A. Bélanger, and J. Fiet. "Effects of RU 486 on adrenal steroidogenesis in the guinea-pig." Journal of Endocrinology 130, no. 1 (1991): 71–78. http://dx.doi.org/10.1677/joe.0.1300071.

Full text

Abstract:

ABSTRACT Recent reports have shown that RU 486, a synthetic glucocorticoid and progestin antagonist, has direct effects on tissues secreting steroids. In order to characterize the effects of RU 486 on steroidogenesis further, guinea-pig fasciculata-glomerulosa (FG) cells in primary culture were treated for 48 h with RU 486. RU 486 caused an alteration of basal as well as ACTH-stimulated steroid secretion. Corticosterone and cortisol secretion decreased by 50% while the secretion of 17-hydroxyprogesterone and C19 steroids were increased. The activity of steroidogenic enzymes was measured using

APA, Harvard, Vancouver, ISO, and other styles

26

Couzinet, Beatrice, Geri Meduri, Maria G. Lecce, et al. "The Postmenopausal Ovary Is Not a Major Androgen-Producing Gland." Journal of Clinical Endocrinology & Metabolism 86, no. 10 (2001): 5060–66. http://dx.doi.org/10.1210/jcem.86.10.7900.

Full text

Abstract:

It is currently believed that the postmenopausal ovary remains a gonadotropin-driven, androgen-producing gland. However, the adrenal contribution to circulating androgen levels may explain some conflicting results previously reported. In addition, the steroidogenic potential and gonadotropin responsiveness of the postmenopausal ovary have not been recently reassessed. Plasma T, bioavailable T, free T, androstenedione (Adione), and dehydroepiandrosterone sulfate levels were measured in postmenopausal or ovariectomized women with complete adrenal insufficiency, compared with women with intact ad

APA, Harvard, Vancouver, ISO, and other styles

27

Sewer, MB, and MR Waterman. "cAMP-dependent transcription of steroidogenic genes in the human adrenal cortex requires a dual-specificity phosphatase in addition to protein kinase A." Journal of Molecular Endocrinology 29, no. 1 (2002): 163–74. http://dx.doi.org/10.1677/jme.0.0290163.

Full text

Abstract:

Steroid hormone biosynthesis in the adrenal cortex is controlled by the peptide hormone adrenocorticotropin (ACTH), which acts to increase intracellular cAMP and results in the activation of cAMP-dependent protein kinase A (PKA) and subsequent increase in steroidogenic gene transcription. Protein phosphorylation by PKA activates transcription of genes encoding steroidogenic enzymes; however the precise proteins which are phosphorylated remain to be determined. We have recently shown that phosphoprotein phosphatase (PP) activity is essential for cAMP-dependent transcription of the human CYP17 (

APA, Harvard, Vancouver, ISO, and other styles

28

Mueller, Matthias, Igor Cima, Mario Noti, et al. "The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine." Journal of Experimental Medicine 203, no. 9 (2006): 2057–62. http://dx.doi.org/10.1084/jem.20060357.

Full text

Abstract:

The nuclear receptor liver receptor homologue-1 (LRH-1, NR5A2) is a crucial transcriptional regulator of many metabolic pathways. In addition, LRH-1 is expressed in intestinal crypt cells where it regulates the epithelial cell renewal and contributes to tumorigenesis through the induction of cell cycle proteins. We have recently identified the intestinal epithelium as an important extra-adrenal source of immunoregulatory glucocorticoids. We show here that LRH-1 promotes the expression of the steroidogenic enzymes and the synthesis of corticosterone in murine intestinal epithelial cells in vitr

APA, Harvard, Vancouver, ISO, and other styles

29

Suda, Noriko, Hirotaka Shibata, Isao Kurihara, et al. "Coactivation of SF-1-Mediated Transcription of Steroidogenic Enzymes by Ubc9 and PIAS1." Endocrinology 152, no. 6 (2011): 2266–77. http://dx.doi.org/10.1210/en.2010-1232.

Full text

Abstract:

Steroidogenic factor-1 (SF-1) is a nuclear orphan receptor, which is essential for adrenal development and regulation of steroidogenic enzyme expression. SF-1 is posttranslationally modified by small ubiquitin-related modifier-1 (SUMO-1), thus mostly resulting in attenuation of transcription. We investigated the role of sumoylation enzymes, Ubc9 and protein inhibitors of activated STAT1 (PIAS1), in SF-1-mediated transcription of steroidogenic enzyme genes in the adrenal cortex. Coimmunoprecipitation assays showed that both Ubc9 and PIAS1 interacted with SF-1. Transient transfection assays in a

APA, Harvard, Vancouver, ISO, and other styles

30

Kelly, Sinead N., T. Joseph McKenna, and Leonie S. Young. "Coregulatory protein–orphan nuclear receptor interactions in the human adrenal cortex." Journal of Endocrinology 186, no. 1 (2005): 33–42. http://dx.doi.org/10.1677/joe.1.06005.

Full text

Abstract:

The capacity of the adrenal to produce steroids is controlled in part through the transcriptional regulation of steroid enzymes. The orphan nuclear receptor steroidogenic factor 1 (SF-1) is central to the transcriptional regulation of all steroid hydroxylase enzymes, whereas nur77 can preferentially regulate steroid enzyme genes relevant to cortisol production. We hypothesised that, in the presence of secretagogues, SF-1 and nur77 may differentially interact with coregulatory proteins in the human adrenal cortex. Both coregulatory proteins, steroid receptor coactivator (SRC-1) and silencing me

APA, Harvard, Vancouver, ISO, and other styles

31

Smeets, Evelien E. J. W., Paul N. Span, Antonius E. van Herwaarden, et al. "Molecular Characterization of Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia: Lesions With Both Adrenocortical and Leydig Cell Features." Journal of Clinical Endocrinology & Metabolism 100, no. 3 (2015): E524—E530. http://dx.doi.org/10.1210/jc.2014-2036.

Full text

Abstract:

Context: Testicular adrenal rest tumors (TART) are one of the major long term complications in patients with congenital adrenal hyperplasia. Although several adrenal-like properties have been assigned to these benign lesions, the etiology has not been confirmed yet. Objective: The aim of this study was to describe TART in more detail by analyzing several (steroidogenic) characteristics that may be classified as adrenal cortex or Leydig cell specific. Methods: Gene expression analysis by qPCR was performed for 14 genes in TART tissue (n = 12) and compared with the expression in healthy control

APA, Harvard, Vancouver, ISO, and other styles

32

Simpson, Evan R., and Michael R. Waterman. "Regulation of the Synthesis of Steroidogenic Enzymes in Adrenal Cortical Cells by ACTH." Annual Review of Physiology 50, no. 1 (1988): 427–40. http://dx.doi.org/10.1146/annurev.ph.50.030188.002235.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

WENG, Qiang, Yumiko TANAKA, Hiroyuki TANIYAMA, et al. "Immunolocalization of Steroidogenic Enzymes in Equine Fetal Adrenal Glands During Mid-Late Gestation." Journal of Reproduction and Development 53, no. 5 (2007): 1093–98. http://dx.doi.org/10.1262/jrd.18159.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Ayub, M., and M. J. Levell. "Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole." Journal of Steroid Biochemistry 32, no. 4 (1989): 515–24. http://dx.doi.org/10.1016/0022-4731(89)90384-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Sirianni, R., BR Carr, S. Ando, and WE Rainey. "Inhibition of Src tyrosine kinase stimulates adrenal androgen production." Journal of Molecular Endocrinology 30, no. 3 (2003): 287–99. http://dx.doi.org/10.1677/jme.0.0300287.

Full text

Abstract:

A unique characteristic of the primate adrenal is the ability to produce 19-carbon steroids, often called the adrenal androgens. Although it is clear that the major human adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S), are produced almost solely in the adrenal reticularis, the mechanisms regulating production are poorly understood. Herein, we tested the hypothesis that the Src family of tyrosine kinases are involved in the regulation of adrenal androgen production. The NCI-H295R human adrenal cell line and primary human adrenal cells in culture were used to study ad

APA, Harvard, Vancouver, ISO, and other styles

36

Wu, Yan-Wan, Constance L. Chik, Barry D. Albertson, W. Marston Linehan, and Richard A. Knazek. "Inhibitory effects of gossypol on adrenal function." Acta Endocrinologica 124, no. 6 (1991): 672–78. http://dx.doi.org/10.1530/acta.0.1240672.

Full text

Abstract:

Abstract. Gossypol, an antifertility agent, has inhibitory actions on many membrane-associated enzymes, suggesting that this agent might have a generalized effect on cell membranes. This hypothesis was examined in the present study using membranes and dispersed cells prepared from human and rat adrenal glands. Four parameters were determined: microviscosity as measured by fluorescence polarization of human adrenal microsomal- and mitochondrial-enriched membranes, adrenal steroidogenic enzymes; and cAMP and cortisol responses to ACTH. It was found that gossypol increased the polarization consta

APA, Harvard, Vancouver, ISO, and other styles

37

Wang, ZN, M. Bassett, and WE Rainey. "Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase." Journal of Molecular Endocrinology 27, no. 2 (2001): 255–58. http://dx.doi.org/10.1677/jme.0.0270255.

Full text

Abstract:

Liver receptor homologue-1 (LRH-1, designated NR5A2) is a mammalian homologue of Drosophila fushi tarazu factor (dFTZ-F1) and structurally belongs to the orphan nuclear receptor superfamily. LRH-1 can recognize the DNA sequence 5'-AAGGTCA-3', the canonical recognition motif for steroidogenic factor 1 (SF-1). Herein, we hypothesized that LRH-1 might play a role in the regulation of human adrenal expression of steroidogenic enzymes. To test this hypothesis, LRH-1 expression in human adult and fetal adrenal glands was examined by RT-PCR analysis. The fetal and adult adrenal glands, as well as liv

APA, Harvard, Vancouver, ISO, and other styles

38

Crawford, P. A., Y. Sadovsky, and J. Milbrandt. "Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage." Molecular and Cellular Biology 17, no. 7 (1997): 3997–4006. http://dx.doi.org/10.1128/mcb.17.7.3997.

Full text

Abstract:

The orphan nuclear receptor steroidogenic factor 1 (SF-1) is expressed in the adrenal gland and gonads and is an important regulator of the expression of cytochrome P-450 steroidogenic enzymes in cultured cells. Targeted disruption of the SF-1 gene in mice shows that it is a critical participant in the genetic program that promotes the development of urogenital mesoderm into the adrenal gland and gonads. To assess the ability of SF-1 to regulate this differentiation pathway, we ectopically expressed SF-1 in murine embryonic stem (ES) cells. We found that stable expression of SF-1 is sufficient

APA, Harvard, Vancouver, ISO, and other styles

39

Wenzel, Jan, Nicole Grabinski, Cordula A. Knopp, et al. "Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 297, no. 5 (2009): R1601—R1609. http://dx.doi.org/10.1152/ajpregu.91034.2008.

Full text

Abstract:

Hypocretins/orexins act through two receptor subtypes: OX1 and OX2. Outside the brain, orexin receptors are expressed in adrenal glands, where orexins stimulate the release of glucocorticoids. To further address the regulation of steroidogenesis, we analyzed the effect of orexins on the expression of steroidogenic enzymes in human adrenocortical National Cancer Institute (NCI) H295R cells by qPCR. In NCI H295R cells, OX2 receptors were highly expressed, as they were in human adrenal glands. After treatment of NCI H295R cells with orexin A for 12–24 h, the cortisol synthesis rate was significan

APA, Harvard, Vancouver, ISO, and other styles

40

Baker, Michael E. "Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptors." Molecular and Cellular Endocrinology 215, no. 1-2 (2004): 55–62. http://dx.doi.org/10.1016/j.mce.2003.11.007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Mellon, S. H., and C. F. Deschepper. "NEUROSTEROID BIOSYNTHESIS: GENES FOR ADRENAL STEROIDOGENIC ENZYMES ARE EXPRESSED REGIONALLY IN THE RAT BRAIN." Pediatric Research 33 (May 1993): S9. http://dx.doi.org/10.1203/00006450-199305001-00038.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Conley, A. J., J. R. Head, D. T. Stirling, and J. I. Mason. "Expression of steroidogenic enzymes in the bovine placenta and fetal adrenal glands throughout gestation." Endocrinology 130, no. 5 (1992): 2641–50. http://dx.doi.org/10.1210/endo.130.5.1374010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Foster, Christy A., Gail J. Mick, Xudong Wang, and Kenneth McCormick. "Evidence that adrenal hexose-6-phosphate dehydrogenase can effect microsomal P450 cytochrome steroidogenic enzymes." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833, no. 9 (2013): 2039–44. http://dx.doi.org/10.1016/j.bbamcr.2013.05.001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Suzuki, Hiromichi, Hirotaka Shibata, Tatsuya Maruyama, Yuzuru Ishimura, and Takao Saruta. "Significance of steroidogenic enzymes in the pathogenesis of hyperfunctioning and non-hyperfunctioning adrenal tumor." Steroids 60, no. 1 (1995): 42–47. http://dx.doi.org/10.1016/0039-128x(94)00025-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Myers, Dean A., Kimberly Hyatt, Malgorzata Mlynarczyk, Ian M. Bird, and Charles A. Ducsay. "Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 289, no. 6 (2005): R1707—R1714. http://dx.doi.org/10.1152/ajpregu.00343.2005.

Full text

Abstract:

Basal plasma ACTH1–39 concentrations are elevated in long-term hypoxic (LTH) fetal sheep. This study was designed to determine whether the expression of genes regulating cortisol biosynthesis was altered after LTH. Pregnant ewes were maintained at high altitude (3,820 m) from day 30 of gestation to near term, when the animals were transported to the laboratory. Reduced Po2 was maintained by nitrogen infusion through a maternal tracheal catheter. On days 137–141, fetal adrenal glands were collected from LTH and normoxic control fetuses. Real-time PCR was used to quantify mRNA for steroidogenic

APA, Harvard, Vancouver, ISO, and other styles

46

Yazawa, Takashi, Yoshitaka Imamichi, Toshio Sekiguchi, et al. "Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells." BioMed Research International 2019 (April 1, 2019): 1–13. http://dx.doi.org/10.1155/2019/8973076.

Full text

Abstract:

Ovaries represent one of the primary steroidogenic organs, producing estrogen and progesterone under the regulation of gonadotropins during the estrous cycle. Gonadotropins fluctuate the expression of various steroidogenesis-related genes, such as those encoding steroidogenic enzymes, cholesterol deliverer, and electronic transporter. Steroidogenic factor-1 (SF-1)/adrenal 4-binding protein (Ad4BP)/NR5A1 and liver receptor homolog-1 (LRH-1) play important roles in these phenomena via transcriptional regulation. With the aid of cAMP, SF-1/Ad4BP and LRH-1 can induce the differentiation of stem ce

APA, Harvard, Vancouver, ISO, and other styles

47

Sirianni, R., JB Seely, G. Attia, et al. "Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes." Journal of Endocrinology 174, no. 3 (2002): R13—R17. http://dx.doi.org/10.1677/joe.0.174r013.

Full text

Abstract:

In the current study we test the hypothesis that liver receptor homologue-1 (LRH; designated NR5A2) is involved in the regulation of steroid hormone production. The potential role of LRH was assessed by first examining expression in human steroidogenic tissues and second by examining effects on transcription of genes encoding enzymes involved in steroidogenesis. LRH is closely related to steroidogenic factor 1 (SF1; designated NR5A1), which is expressed in most steroidogenic tissues and regulates expression of several steroid-metabolizing enzymes. LRH transcripts were expressed at high levels

APA, Harvard, Vancouver, ISO, and other styles

48

Shigematsu, Kazuto, Kioko Kawai, Junji Irie, et al. "Analysis of Unilateral Adrenal Hyperplasia with Primary Aldosteronism from the Aspect of Messenger Ribonucleic Acid Expression for Steroidogenic Enzymes: A Comparative Study with Adrenal Cortices Adhering to Aldosterone-Producing Adenoma." Endocrinology 147, no. 2 (2006): 999–1006. http://dx.doi.org/10.1210/en.2005-0765.

Full text

Abstract:

Unilateral adrenal hyperplasia with primary aldosteronism is very rare and shows similar endocrine features to aldosterone-producing adenoma and bilateral adrenal hyperplasia. In this study, the mRNA expression of steroidogenic enzymes in unilateral adrenal hyperplasia was examined by in situ hybridization. We found subcapsular micronodules composed of spironolactone body-containing cells, which showed intense expression for 3β-hydroxysteroid dehydrogenase, 11β-hydroxylase, 18-hydroxylase, and 21-hydroxylase but not 17α-hydroxylase, indicating aldosterone production. This expression pattern wa

APA, Harvard, Vancouver, ISO, and other styles

49

Kim, Jae Hyun, Young Ah Lee, Youn-Hee Lim, et al. "Changes in Adrenal Androgens and Steroidogenic Enzyme Activities From Ages 2, 4, to 6 Years: A Prospective Cohort Study." Journal of Clinical Endocrinology & Metabolism 105, no. 10 (2020): 3265–72. http://dx.doi.org/10.1210/clinem/dgaa498.

Full text

Abstract:

Abstract Context The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis. Objective We investigated longitudinal changes in androgen levels and steroidogenic enzyme activities during early childhood. Design and Participants From a prospective children’s cohort, the Environment and Development of Children cohort, 114 boys and 86 girls with available blood samples from ages 2, 4, and 6 years were included. Outcome Measurements Serum concentrations of adrenal androgens using liquid chromatography-tandem m

APA, Harvard, Vancouver, ISO, and other styles

50

Gal, Michael, and Joseph Orly. "Selective Inhibition of Steroidogenic Enzymes by Ketoconazole in Rat Ovary Cells." Clinical Medicine Insights: Reproductive Health 8 (January 2014): CMRH.S14036. http://dx.doi.org/10.4137/cmrh.s14036.

Full text

Abstract:

Objective Ketoconazole (KCZ) is an anti-fungal agent extensively used for clinical applications related to its inhibitory effects on adrenal and testicular steroidogenesis. Much less information is available on the effects of KCZ on synthesis of steroid hormones in the ovary. The present study aimed to characterize the in situ effects of KCZ on steroidogenic enzymes in primary rat ovary cells. Methods Following the induction of folliculogenesis in gonadotropin treated rats, freshly prepared ovarian cells were incubated in suspension for up to four hours while radiolabeled steroid substrates we

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!