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Dissertations / Theses on the topic 'RORα'

Author: Grafiati

Published: 25 June 2021

Last updated: 29 July 2025

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1

Nikitin, Artemii. "Role of nuclear receptor RORα in regulatory T cells". Thesis, Université de Lille (2018-2021), 2019. http://www.theses.fr/2019LILUS073.

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Les facteurs de transcription de la superfamille des récepteurs nucléaires jouent de multiples rôles dans le développement et la fonction des lymphocytes T régulateurs (TREG). Les TREG sont des cellules régulatrices/suppressives qui contrôlent les réponses d’autres types cellulaires et l’homéostasie locale des tissus.Comme les TREG sont actives au sein de divers organes, tant à l’homéostasie qu’en conditions inflammatoires,ils doivent répondre à la fois aux contexte local au sein du tissus et à un environnement immunologiquement agressif tout en préservant leurs propriétés tolérogéniques au co

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Boukhtouche, Fatiha. "Rôle du récepteur nucléaire RORα dans la survie et la différenciationneuronale". Phd thesis, Université Pierre et Marie Curie - Paris VI, 2006. http://tel.archives-ouvertes.fr/tel-00080417.

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RORα (Retinoic acid receptor related Orphan Receptor α) est un récepteur nucléaire<br />dont la perte de fonction entraîne chez la souris staggerer - entre autres phénotypes - une<br />sévère ataxie cérébelleuse. RORα a longtemps été considéré comme un récepteur nucléaire<br />orphelin, cependant, le cholestérol (ou un de ses dérivés) semble être un ligand physiologique<br />de ce récepteur.<br />Le mutant staggerer, identifié dès 1962 par Sidman, Lane et Dickie, présente une<br />hypoplasie cérébelleuse liée à l'absence de la grande majorité des cellules de Purkinje, ainsi<br />que des grains

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3

Journiac, Nathalie. "Etude du rôle du facteur de transcription RORα dans la réaction gliale". Paris 6, 2007. http://www.theses.fr/2007PA066031.

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Notre objectif était de déterminer le rôle de RORalpha dans l’activation des astrocytes associée à une neurodégénérescence. Nous avons utilisé la souris staggerer exprimant une mutation perte de fonction dans le gène Rora à l’origine de la dégénérescence des neurones cérébelleux et réalisé des transfections stables de lignées astrocytaires. Nous avons montré que RORalpha, jusqu’alors considéré comme exclusivement neuronal, est exprimé dans les astrocytes et démontré qu’il module : -l’expression de la GFAP, un marqueur spécifique de l’activation astrocytaire. -la prolifération, avec un effet di

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4

Boukhtouche, Fatiha. "Rôle du récepteur nucléaire RORα dans la survie et la différentiation des neurones". Paris 6, 2006. http://www.theses.fr/2006PA066007.

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Sermikli, Benan Pelin. "Role of the nuclear receptor RORα expressed by myeloid cells in metabolic diseases". Thesis, Lille 2, 2020. http://www.theses.fr/2020LIL2S019.

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Retinoic acid receptor-related orphan receptor-alpha (RORa) is a transcription factor from the nuclearreceptor superfamily expressed by immune and non-immune cells involved in the regulation of obesity, insulin resistance (IR) and non-alcoholic steatohepatitis (NASH). Cholesterol, cholesterol-sulfate, 7-oxygenated sterols and oxysterols have been identified as potential endogenous RORa ligands. Tobetter understand the mechanisms of macrophage-expressed RORa regulation in obesity and IR, we generated a macrophage-specific RORa-deficient (MKO) mouse line by using a LysM-Cre and floxedRORa mouse

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6

Ermisch, Michael [Verfasser], Dieter [Akademischer Betreuer] Steinhilber та Rolf [Akademischer Betreuer] Marschalek. "Regulation der nukleären Rezeptoren RORα und REVERBα / Michael Ermisch. Gutachter: Dieter Steinhilber ; Rolf Marschalek". Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2011. http://d-nb.info/1044274638/34.

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Gineste, Romain. "Régulation de l'activité transcriptionnelle des récepteurs nucléaires FXR, RORα et PPARγ par modifications post-traductionnelles". Lille 2, 2008. http://www.theses.fr/2008LIL2S041.

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Les facteurs de transcriptions FXR, RORα et PPARγ appartiennent à la superfamille des récepteurs nucléaires (RN). Ils ont pour fonction de moduler l'expression de nombreux gènes impliqués dans de nombreux processus physiologiques. Leurs rôles dans l'homéostasie glucidique, lipidique et énergétique font de ces récepteurs des cibles pharmacologiques d'intérêt pour le traitement de nombreuses maladies métaboliques comme les dyslipidémies, le diabète de type II, l'athérosclérose, l'obésité et les maladies neuro-dégénératives. Les RN activent leurs gènes cibles en se liant à l'ADN, sur une séquence

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8

Kadiri, Sarah. "Inflammation du tissu adipeux et dysfonctions de l'homéostasie lipidique : différences spécifiques de dépôts chez l'humain et la souris, et implication RORα". Paris 6, 2013. http://www.theses.fr/2013PA066518.

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Le tissu adipeux (TA) joue un rôle central dans l’homéostasie lipidique par ses capacités de stockage/déstockage des acides gras (AG). La voie de la glycéronéogenèse (GNG), qui permet la ré-estérification des acides gras en période de jeûne, participe à l’homéostasie lipidique en limitant la lipotoxicité des AG et leur localisation ectopique. Nous avons traité des explants de TA sous-cutané (TASC) et viscéral (TAV) issus de femmes minces par des inhibiteurs de la protéase du VIH (en cause dans les lipodystrophies) ou le lipopolysaccharide. Mes travaux ont mis en évidence une atteinte du TASC e

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9

Kagwiria, Rosebeth [Verfasser], та Lars [Gutachter] Nitschke. "Evaluation of the nuclear receptor Retinoic Acid Receptor related Orphan Receptor α (RORα) as a regulator of osteoclastogenesis in rheumatoid arthritis and osteoporosis / Rosebeth Kagwiria ; Gutachter: Lars Nitschke". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017. http://d-nb.info/1140228609/34.

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10

Boyault, Sandrine. "Modulation des effets et de la production de l'interleukine-1ß par des ligands des récepteurs nucléaires : PPAR, "peroxisome proliferator-activated receptor" et RORα "retinoic acid receptor-related orphan receptor alpha" dans les tissus de l'articulation". Nancy 1, 2003. http://docnum.univ-lorraine.fr/public/SCD_T_2003_0245_BOYAULT.pdf.

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La destruction progressive du cartilage, caractéristique commune des arthropathies inflammatoires et dégénératives, résulte d 'un déséquilibre entre les processus de synthèse et de dégradation matricielle. L'interleukine-l (IL-1) joue un rôle central dans la perte d 'homéostasie du cartilage lors de ces pathologies articulaires. Cette cytokine induit la production de médiateurs de l'inflammation, tels que le monoxyde d'azote (NO) et les prostaglandines ainsi que l'expression d'enzymes protéolytiques. La modulation des effets et/ou de la production d'IL-l par les chondrocytes et les synoviocyte

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Genoux, Annelise. "Régulation différentielle de la transcription des gènes murin et humain de l'apolipoprotéine A5 en réponse aux cytokines pro-inflammatoires par différents mécanismes impliquant respectivement NF-kB ou COUP-TFI : régulation transcriptionnelle du gène de l'APOA5 par RORα". Lille 2, 2006. http://www.theses.fr/2006LIL2S007.

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L'hypertriglycéridémie, considérée comme un facteur de risque indépendant de maladies cardiovasculaires, est souvent associée à des pathologies métaboliques et inflammatoires. L'apolipoprotéine A5 (APOA5), récemment découverte, exerce un rôle majeur dans l'homéostasie des triglycérides. De ce fait l'étude des facteurs régulant son expression est particulièrement intéressante. La première partie de nos travaux vise à déterminer le rôle de l'APOA5 dans l'inflammation en étudiant la régulation de son expression génique par les cytokines pro-inflammatoires et d'élucider le ou les mécanismes molécu

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Liang, Ruifang [Verfasser], Jörg [Akademischer Betreuer] Distler та Michael [Gutachter] Stürzl. "Novel Insights into Hedgehog Signaling in Systemic Sclerosis at the level of GLI2 and HHAT and Characterization of the Role of the Orphan Nuclear Receptor RORα in Fibroblast Activation and Tissue Fibrosis / Ruifang Liang ; Gutachter: Michael Stürzl ; Betreuer: Jörg Distler". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2021. http://d-nb.info/122642807X/34.

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13

Amundin, Eskil. "Modeling of fatigue in RORO ships." Thesis, KTH, Marina system, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-119767.

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The largest modern Pure Car and Truck Carriers (PCTC’s) are typically 230 meters long and have 13 cargo decks. In order to facilitate rapid loading and unloading these ships have been subject to a development of reducing any obstructing structures in the cargo hold, meaning that the transversal shear preventing structures, i.e. the racking bulkheads, has been taken to a minimum. Previous studies have concluded that some points on the racking bulkheads, as a result of the stripped down design, are subject to high stresses resulting from wave induced accelerations of the ship. In this M.Sc. Thes

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14

Chauvet, Caroline. "Etude du rôle du récepteur nucléaire RORa : analyse des effets de l'hypoxie sur l'expression du gène Rora et recherche de gènes cibles de RORa dans le foie." Paris 11, 2004. http://www.theses.fr/2004PA11T027.

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15

Pristrom, Sascha [Verfasser]. "Untersuchung zur Einschätzung von Schwimmlage und Stabilität an Bord von RoRo und RoRo-Passagierschiffen im Wassereinbruchfall / Sascha Pristrom." Wuppertal : Universitätsbibliothek Wuppertal, 2011. http://d-nb.info/1010773038/34.

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16

Paredes, Moscosso Solange Rosa. "ROR1 as a target for cancer immunotherapy." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10038730/.

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Receptor tyrosine-kinase like orphan receptor (ROR1) is a member of the tyrosine kinase family. Importantly, ROR1 is absent in healthy, critical tissue but overexpressed in various solid and haematological malignancies, including Chronic Lymphocytic Leukaemia (CLL). Moreover, recent studies suggest ROR1 is expressed on cancer stem cell-like cells (CSCs). The overriding aim of this study was therefore to combine the unique features of ROR1 with the exquisite specificity/therapeutic potential of monoclonal antibodies (MAbs) and/or their derivatives. To this end, our group generated a rat hybrido

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Winkel, Andreas. "Die Signalvermittlung der Rezeptor-Tyrosinkinase Ror2 in mesenchymalen Bindegewebszellen." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976523868.

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Tews, Rory [Verfasser]. "Social entrepreneurship in Germany: A Bourdieuan perspective / Rory Tews." Bielefeld : Universitätsbibliothek Bielefeld, 2015. http://d-nb.info/1080129863/34.

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19

Grieg, Thomas Willumsen, Ole Henrik F. Pedersen, and Jørgen Rønholt. "Simulation and Rescheduling of Operation for a RoRo-fleet." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for marin teknikk, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22367.

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This master thesis is a part of the MARFLIX (MARitime FLeet size and mIX) project. The research project MARFLIX is a collaboration between NTNU, MARINTEK, DNV and WWL. The overall aim for the MARFLIX project is to develop and test methods for improved support for fleet size and mix decision-making through quantitative methods. Wallenius Wilhelmsen Logistics (WWL) is a global liner shipping company which delivers shipping and logistics solutions for manufacturers of car, trucks, heavy equipment and specialized cargo. In this master thesis a framework model that is able to test and verify deploy

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Allen, John C. "FGF4 Induced Wnt5a Gradient in the Limb Bud Mediates Mesenchymal Cell Directed Migration and Division." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4309.

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The AER has a vital role in directing embryonic limb development. Several models have been developed that attempt to explain how the AER directs limb development, but none of them are fully supported by existing data. I provide evidence that FGFs secreted from the AER induce a gradient of Wnt5a. I also demonstrate that limb mesenchyme grows toward increasing concentrations of Wnt5a. We hypothesize that the changing shape of the AER is critical for patterning the limb along the proximal to distal axis. To better understand the pathway through which Wnt5a elicits its effects, we have performed v

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Wathne, Eivind. "Cargo Stowage Planning in RoRo Shipping : Optimisation Based Naval Architecture." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for marin teknikk, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-18597.

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Operations research has proven itself to be advantageous in several areas of the industry for many years, but is operations research a good approach to operational maritime planning? Expressions used to calculate the initial stability of a vessel are often non-linear. Optimisation models demand linearity, and approximated linearisations of the proven stability formulas needed to be developed. This was arguably found to be the biggest challenge when modelling the cargo stowage optimisation model. The characteristics of the RoRo shipping industry have been examined to gain a better understand of

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Lloyd, Angela Jane. "Modal representation in the early madrigals of Cipriano de Rore." Thesis, Royal Holloway, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362748.

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23

vadlamudi, jithin chand. "How a Discrete event simulation model can relieve congestion at a RORO terminal gate system : Case study: RORO port terminal in the Port of Karlshamn." Thesis, Blekinge Tekniska Högskola, Institutionen för datalogi och datorsystemteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-11720.

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Context. Due to increase in demand for RORO shipping services,the RORO terminal gate system need to handle more number of vehicles for every RORO vessel departure. Therefore, various congestion problems can occur; so, to address all possible congestion related problemsat RORO terminal, terminal gate systems are implemented with advanced technologies and updated to full or partial functioning automated gate systems. Objectives. In this research study considering the future increase in demand for wheeled cargo shipping, we attempt to propose a solution for reducing congestion and investigating o

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Alqattan, Humoud. "An estimation model for private rate of return on education in high income petroleum based developing countries : the case of Kuwait." Thesis, Brunel University, 2013. http://bura.brunel.ac.uk/handle/2438/7650.

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The benefits of a good education are numerous; it not only offers knowledge and power to individuals, but also enables them to lead the life they wish to; and to benefit both their own family and country. Education has a positive impact on the development of a country. An educated society can eradicate poverty, illiteracy and unemployment, and help in the improvement of the health care standards, the political structures, and the national productivity. The contribution of education in this development process is evident and easily recognized. Many studies show that investments in education gen

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Nylén, Christoffer. "Improving MCDC adequate test sets for safety critical software to be RORG adequate." Thesis, Linköpings universitet, Programvara och system, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121729.

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A number of logical code coverage criteria have been used throughout the years in the testing of safety-critical software. Kaminski, et al. proposed Relational Operator Replacement Global (RORG), a method to bring benefits from ROR mutation to Modified Condition / Decision Coverage (MCDC), which is widely used in the avionics industry. However, there is a lack of studies in the industry to support this method. In this thesis, we report on the results of applying RORG to avionic code, augmenting an MCDC adequate test set to satisfy RORG, evaluating its ability to find real faults in industrial

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Mangan, Daniel John. "A triangulated study of decision making in RoRo port/ferry choice." Thesis, Cardiff University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341586.

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Alhomidan, Abdullah. "INVESTIGATION OF TRAFFIC CRASHES IN TWO-LANE RURAL HIGHWAYS IN OHIO." University of Akron / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1165259225.

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Martinez, Sébastien. "Rôle de la protéine tyrosine kinase 7 dans le cancer colorectal et la polarité planaire cellulaire." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4019.

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La voie de signalisation WNT/PCP, couramment associée à la polarité planaire cellulaire, joue un rôle fondamental dans la morphogenèse chez les vertébrés. Parmi les différents composants protéiques de la voie WNT/PCP, on retrouve la protéine tyrosine kinase 7 (PTK7), dont les fonctions restent encore très peu décrites. Au cours de ma thèse, j’ai montré que PTK7 interagissait avec le récepteur tyrosine kinase ROR2. Ce complexe, après fixation du ligand WNT5A, induit la migration de fibroblastes embryonnaires murins via l’activation de JNK. Au cours du développement embryonnaire du xénope, Ptk7

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Raschig, Barbara. "Bizarre Welten Ror Wolf von A bis Z /." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=964177846.

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Yahia, Hanane. "Regulation of RORC2 expression during human CD4+T cell differentiation." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC289.

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La différentiation des lymphocytes Th17 dépend fortement du facteur de transcription RORγt. RORγt a été identifié pour la première fois chez la souris comme un facteur spécifique des thymocytes, jouant un rôle important dans le développement du thymus. En effet, RORγt est exprimé sélectivement dans le stade double positif (DP) et il est ensuite réprimé dans le stade simple positif (SP) ainsi que dans les cellules CD4+ naïves périphériques. Les mécanismes moléculaires qui régulent l’expression transitoire de RORγt dans le thymus et en périphérie sont peu connus. Le but de ce projet est de défin

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Rice, Edward. "Rory lines : silver lining for seabirds in South Africa's demersal trawl fisheries." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/10902.

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Includes bibliographical references.<br>Seabird bycatch in commercial fisheries is one of the major factors causing decreases in many seabird populations. In trawl fisheries, high mortalities have been recorded as a result of seabirds being struck by trawl warps (the cables used to tow the trawl net). Tori (bird-scaring) lines have been used to decrease seabird mortality in some trawl fisheries by up to 90%. However, tori lines are not effective at reducing the number of birds that drift towards the trawl warps while feeding on factory discards alongside the vessel. The Albatross Task Force (A

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Schick, Hartmut. "Musikalische Einheit im Madrigal von Rore bis Monteverdi : Phänomene, Formen und Entwicklungslinien /." Tutzing : H. Schneider, 1998. http://catalogue.bnf.fr/ark:/12148/cb369686802.

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Mani, Rajeswaran. "Preclinical development of a non-immunosuppressive FTY720 derivative OSU-2S forchronic lymphocytic leukemia and other B-cell malignancies." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1404067069.

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Kohlenberger, Judith, and Isabella Buber-Ennser. "Who are the refugees that came to Austria in fall 2015?" Austrian Academy of Sciences Institute for Social Anthropology, 2017. http://epub.wu.ac.at/5375/1/ROR%2DN_Blog_post_Kohlenberger_FINAL.pdf.

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Borcherding, Nicholas. "Noncanonical Wnt signaling in breast cancer initiation and progression." Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/1294.

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Besnard, Sandrine. "Expression et fonctions de ROR alpha dans le système vasculaire." Paris 7, 2001. http://www.theses.fr/2001PA077169.

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Edey, Caitlin. "Retinoid-mediated Regulation of NR6A1, Prickle1 and Ror2 During Development of the Mouse Embryo." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23609.

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Vitamin A and its derivatives, collectively termed retinoids, are essential for proper growth and development as well as maintenance of homeostasis in the adult. Retinoic acid (RA), the major biologically active vitamin A metabolite, is well characterized for its crucial roles in gene activation during embryogenesis. Our lab had previously performed a microarray analysis to identify genes induced by exogenous RA in the tailbud of early mouse embryos. Three genes were chosen from the microarray results for further investigation; Germ Cell Nuclear Factor (GCNF/NR6A1), Prickle1 (Pk1) and Ror2, th

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Susman, Michael Wen. "The Wnt5a-Ror Signaling Pathway in the Morphogenesis of the Embryo." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845401.

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Embryonic development is orchestrated by relatively few conserved core developmental signaling pathways that are used reiteratively to grow, specify and shape all tissues in the body into their final functional forms. The Wnt5a signaling pathway is necessary to shape and extend various tissues during morphogenesis, but how Wnt5a signals within cells has long remained unclear and controversial. Through loss-of-function experiments in mice, we demonstrate that the Ror family of receptors mediates Wnt5a-dependent processes in vivo at multiple stages of embryonic development. Of previously propose

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Lucas, Murilo Cesar. "Influência da precipitação e do uso solo sobre a taxa de recarga em zona de afloramento do Sistema Aquífero Guarani." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-31102012-092335/.

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As maiores taxas de recarga subterrânea do Sistema Aquífero Guarani (SAG) ocorrem nas áreas de afloramento das Formações Botucatu e Pirambóia. O principal objetivo deste trabalho foi avaliar as taxas de recarga subterrânea e suas relações com as variações da precipitação e do uso do solo na bacia hidrográfica do Ribeirão da Onça, situada em área de afloramento do SAG. A variação do nível freático foi medida em 11 poços de monitoramento, distribuídos em diferentes culturas agrícolas na bacia, durante o período de estudo (Outubro de 2004 até Setembro de 2011). Técnicas de tratamento de imagens m

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Mackenzie, Pierre. "Le langage musical dans les madrigaux tardifs (à partir de 1550) de Cyprien de Rore." Paris 4, 2000. http://www.theses.fr/1999PA040192.

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Cette thèse examine le langage musical des madrigaux tardifs (à partir de 1550), à quatre et à cinq voix de Cyprien de Rore, par une analyse méthodique utilisant les théories musicales de l'époque. La première partie résume l'ensemble de la théorie musicale ayant rapport au madrigal, en particulier les istitutioni harmoniche de Gioseffe Zarlino. Les quatre chapitres traitent respectivement de la mélodie, de l'harmonie, du mode et de la mise en musique des textes, format qui reflète l'organisation des traités théoriques de l'époque. La deuxième partie, divisée en cinq chapitres, consiste en un

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Lo, Bernard Clement. "The role of ROR alpha and CD34 in mucosal inflammation and fibrosis." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62443.

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Fibrosis is the result of dysregulated tissue regeneration and is characterized by excessive accumulation of matrix proteins that become detrimental to tissue function. Type 2 immunity has long been associated with fibrotic scarring because of its role in wound healing and parasite-initiated tissue remodeling. Our objective was to examine two components of this inflammatory pathway that could potentially be modulated to limit fibrosis, namely RORα, a nuclear receptor required for ILC2 development, and CD34, a sialomucin involved in trafficking of eosinophils and mast cells to peripheral tissu

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Gohil, Satyen Harish. "Pre-clinical development of novel ROR1 chimeric antigen receptor T cells and bispecific T cell engagers." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10042372/.

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Receptor tyrosine kinase like orphan receptor 1 (ROR1) is an onco-embryonic antigen present on a range of solid and haematological malignancies, including chronic lymphocytic leukaemia. Additionally, limited, low level expression on normal tissues makes it an attractive therapeutic target. Chimeric antigen receptor T cells and Bispecific T Cell Engagers have emerged as exciting immunotherapeutic approaches, utilising the inherent cytotoxic potential of autologous T cells to yield demonstrable benefit for patients. We therefore aimed to generate novel ROR1 CAR T cells and BiTEs. Following a rat

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Lima, Ariadne Ramalho de. "Pesquisa de mutações no gene ROR2 em pacientes com a forma recessiva da síndrome de robinow." reponame:Repositório Institucional da UnB, 2015. http://dx.doi.org/10.26512/2015.07.D.20074.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências Médicas, Programa de Pós-Graduação em Ciências Médicas, 2015.<br>A Síndrome de Robinow se caracteriza por dismorfias faciais associadas a encurtamento mesomélico e genitália hipoplásica. Defeitos de segmentação costovertebral que incluem fusões de costelas também podem ser observados e permitem distinguir os pacientes com a forma autossômica recessiva da síndrome daqueles com a forma autossômica dominante. A forma recessiva é causada por mutações no gene ROR2 (related orphan receptor 2), sendo que apenas dezenove diferentes

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Hinz, Laura Emily [Verfasser], Stefan [Akademischer Betreuer] Engelhardt, Bernhard [Gutachter] Küster та Rory [Gutachter] Koenen. "Phosphorylation of the β1-adrenoceptor / Laura Emily Hinz ; Gutachter: Bernhard Küster, Rory Koenen ; Betreuer: Stefan Engelhardt". München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1139843885/34.

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Dahl, Tiffanie M. "Role of Wnt5a and Possible Pathway of Action Through Ror2 in Proximodistal Outgrowth of the Limb." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2600.

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Despite over 60 years of study, the molecular pathways and mechanisms governing limb outgrowth and patterning remain poorly understood. Fgfs expressed in the AER are known to be necessary and sufficient for proximodistal limb outgrowth and have been proposed to have a chemoattractive role. Wnt5a is a secreted factor which is expressed in a gradient in the distal limb with the highest concentration next to the AER. The presence of the AER is necessary to establish this gradient. Expression of Wnt5a in a concentration dependant manner can be induced in the limb through the implantation of a bead

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Tročil, Jan. "Investigating Risk-On Risk-Off Patterns in Global Financial Markets." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-192459.

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The aim of this thesis is to analyse the increased correlation within four major asset groups (Government Bonds, Equity Indices, Commodities and Currencies) from the beginning of Great Recession till July 2014. The effect of increased correlation is called Risk-On Risk-Off and is connected to problems, where investors struggle to create risk-oriented portfolios and instead minimalize loss. The methods analysing the correlations are Absolute Average Value Index (AAVI) and Heat-map analysis. The AAVI is transforming correlation matrix into a single number and investigating the intensity of corre

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Schmidt, Christina [Verfasser]. "Funktionelle Analyse des Receptor tyrosine kinase-like orphan Receptor 1 (ROR1) bei der chronischen lymphatischen Leukämie / Christina Schmidt." Köln : Deutsche Zentralbibliothek für Medizin, 2013. http://d-nb.info/1042336253/34.

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Takai, Akira. "Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway." Kyoto University, 2011. http://hdl.handle.net/2433/135377.

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Herrmann, Simon [Verfasser], and Henrik [Akademischer Betreuer] Schulze-Koops. "Histonmodifikationen in den Genloki RORC und IL17 bei Patienten mit rheumatoider Arthritis / Simon Herrmann ; Betreuer: Henrik Schulze-Koops." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1148940642/34.

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Jadeland, Maria, and Jessica Harletun. "FAR ROR : MOR ÄR RAR.En studie om användningen av läromedel för läs- och skrivinlärning." Thesis, Kristianstad University College, School of Teacher Education, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-4829.

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<p>Uppsatsen inriktar sig på pedagogers arbete med läromedel för läs- och skrivinlärning med fokus på årskurs ett. I forskningsbakgrunden lyfts teorier och undersökningar inom läs- och skrivinlärning fram. Det finns två motpoler i läs- och skrivinlärningen: syntetisk metod, som utgår från delarna, och analytisk metod, som har sin utgångspunkt i helheten. Vidare tas styrdokumentens roll för läs- och skrivinlärningen upp och diskuteras i förhållande till undersökningens resultat. Syftet med uppsatsen är att se på vilka läromedel några pedagoger använder sig av, hur och varför. Undersökningen gen

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