Relevant bibliographies by topics / ROR1/2

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Conference papers

Academic literature on the topic 'ROR1/2'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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Journal articles on the topic "ROR1/2"

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Balaian, Larissa, Anil Sadarangani, George F. Widhopf, et al. "A Highly Selective Anti-ROR1 Monoclonal Antibody Inhibits Human Acute Myeloid Leukemia CD34+ Cell Survival and Self-Renewal." Blood 120, no. 21 (2012): 2560. http://dx.doi.org/10.1182/blood.v120.21.2560.2560.

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Abstract Abstract 2560 The mammalian orphan receptor tyrosine kinase-1 (ROR1) is expressed in a wide-variety of tissues during early embryonic development. By the late stages of embryogenesis the expression of this developmentally important protein is greatly diminished. Although not expressed in the tissues of post-partum animals, the ROR1 protein is expressed on neoplastic cells in chronic lymphocytic leukemia (CLL), some B-cell malignancies, and a variety of different carcinomas. We examined for expression of ROR1 in primary acute myeloid leukemia (AML) cells harvested from marrow aspirates
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Kipps, Thomas, Laura Z. Rassenti, George F. Widhopf II, and Thomas J. Kipps. "Wnt5a Induces ROR1 Dependent Tyrosine Phosphorylation of DOCK2, and Enhanced Activation of ERK to Promote Proliferation of CLL Cells." Blood 132, Supplement 1 (2018): 4404. http://dx.doi.org/10.1182/blood-2018-99-117175.

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Abstract ROR1 (receptor tyrosine kinase-like orphan receptor 1) is a conserved, oncoembryonic surface antigen expressed in chronic lymphocytic leukemia (CLL) B cells, but not on most normal post-partem tissues. Patients with high-level leukemia-cell expression of ROR1 have been found to have a shorter median time from diagnosis to therapy and shorter median survival than patients with CLL cells that express low-to-negligible amounts of ROR1 (Cui B. et al., Blood, 128:2931, 2016). In prior studies we found that Wnt5a could induce ROR1 to recruit DOCK2 at proline 808 and activate Rac1/2, leading
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Milleck, Julia, Karl-Anton Kreuzer, Mario Assenmacher, Jürgen Schmitz, and Peter S. Jähn. "Characterization of Peripheral B Cells Expressing CLL-Associated Receptor Tyrosine Kinase ROR1 in Healthy Donors." Blood 120, no. 21 (2012): 1787. http://dx.doi.org/10.1182/blood.v120.21.1787.1787.

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Abstract Abstract 1787 Recent studies have described an extensive expression of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) on the surface of malignant B cells in patients suffering from chronic lymphoid leukemia (CLL). ROR1 expression has also been detected in ovarian cancer, renal cancer, melanoma, and lung adenocarcinoma, suggesting a general role of ROR1 in cancer genesis and/or maintenance. However, low levels of ROR1 mRNA or protein expression have also been found on undifferentiated embryonic stem cells, adipose tissue and on early stage of B-cells in bone marrow, but not
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Hasan, Md Kamrul, Jian Yu, George F. Widhopf, et al. "Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia." Blood 132, no. 2 (2018): 170–78. http://dx.doi.org/10.1182/blood-2017-12-819383.

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5

Daneshmanesh, Amir Hossein, Mohammad Hojjat-Farsangi, Asa Sandin, et al. "Monoclonal Antibody Against ROR1 in Chronic Lymphocytic Leukemia Cells Induced Apoptosis Via PI3-Kinase/AKT/CREB Pathway." Blood 120, no. 21 (2012): 1769. http://dx.doi.org/10.1182/blood.v120.21.1769.1769.

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Abstract Abstract 1769 Background: Phosphoinositide 3-kinase (PI3K)/AKT cascade regulates cell survival, proliferation and differentiation in a variety of cells. In CLL cells PI3K pathway is constitutively activated leading to AKT activation and phosphorylation of cAMP response element-binding protein (CREB). CREB is a transcription factor overexpressed and constitutively phosphorylated in a variety of cancers and seems to have a role in tumor pathobiology. There is a great need to develop novel strategies for targeted therapy in CLL. Monoclonal antibodies (mAbs) specifically targeting leukemi
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6

Karvonen, Hanna, David Chiron, Wilhelmiina Niininen, et al. "Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma." Blood Advances 1, no. 24 (2017): 2257–68. http://dx.doi.org/10.1182/bloodadvances.2017010215.

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Key Points Targeting ROR1 downregulates NF-κB p65 expression and sensitizes MCL cells to BCR- or Bcl-2–targeted drugs. Inhibition of BCR signaling by BTK-specific inhibitors such as ibrutinib impairs ROR1 levels and consecutively ROR1-targeted therapies.
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Ghaderi, Amineh, Amir Hossein Daneshmanesh, Ali Moshfegh, et al. "ROR1 is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells." Biomedicines 8, no. 6 (2020): 170. http://dx.doi.org/10.3390/biomedicines8060170.

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The receptor tyrosine kinase ROR1 is absent in most normal adult tissues, but overexpressed in several malignancies. In this study, we explored clinical and functional inhibitory aspects of ROR1 in diffuse large B-cell lymphoma (DLBCL). ROR1 expression in tumor cells was more often observed in primary refractory DLBCL, Richter’s syndrome and transformed follicular lymphoma than in relapsed and non-relapsed DLBCL patients (p < 0.001). A survival effect of ROR1 expression was preliminarily observed in relapsed/refractory patients independent of gender and stage but not of age, cell of origin
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8

Yu, Jian, Bing Cui, George F. Widhopf, et al. "Preclinical Development Of ROR1 Peptide Based Vaccine With Activity Against Chronic Lymphocytic Leukemia In ROR1 Transgenic Mice." Blood 122, no. 21 (2013): 4174. http://dx.doi.org/10.1182/blood.v122.21.4174.4174.

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Abstract Receptor tyrosine kinase-like orphan receptor (ROR1) is expressed on chronic lymphocytic leukemia (CLL) and other cancers, but not on normal post-partum tissues, except for a small subset of precursor B cells known as hematogones. Because of its restricted expression on cancer cells, ROR1 is an attractive target for developing novel anti-cancer therapies. In this study, we designed several different peptides, corresponding to distinct epitopes in the extracellular domain of ROR1. Each peptides was conjugated with keyhole-limpet hemocyanin (KLH) to generate a peptide-KLH vaccine, which
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9

Diamanti, Paraskevi, Bethan Kathleen Bailey, Obinna Ebere Iheanacho, Amit C. Nathwani, and Allison Blair. "Evaluating ROR1 As a Target in Childhood Leukemia." Blood 134, Supplement_1 (2019): 2635. http://dx.doi.org/10.1182/blood-2019-126734.

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Disease relapse in childhood acute lymphoblastic leukemia (ALL) patients may occur due to persistence of resistant cells with leukemia propagating ability (LPC). Immunotherapeutic approaches, such as bi-specific T cell engagers (BiTEs) and chimeric antigen receptor (CAR) T cells against CD19, have been shown to successfully treat relapsed ALL. However, such therapies cannot target LPC that lack or have lost expression of CD19. Receptor tyrosine kinase like orphan 1 receptor (ROR1) is a surface antigen, overexpressed in hematological malignancies, including chronic lymphocytic leukemia (CLL) an
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10

Mellstedt, Håkan, Amineh Ghaderi, Johanna Aschan, et al. "ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells." Blood 134, Supplement_1 (2019): 5312. http://dx.doi.org/10.1182/blood-2019-129773.

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Background: ROR1 - a receptor tyrosine kinase (RTK) - is essential for normal embryonic development, but is absent on most normal adult tissues. ROR1 is of importance of cell proliferation, differentiation, survival and metabolism. However, ROR1 is overexpressed in several types of cancer (onco-fetal RTK). MCL is an aggressive and incurable non-Hodgkin lymphoma characterized by translocation (11;14) (q13;q32) and cyclin D overexpression. ROR1 has been described to be highly expressed in MCL cells. We have previously presented results on a small molecule ROR1 inhibitor in CLL (KAN0439834) (Leuk
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Dissertations / Theses on the topic "ROR1/2"

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Serinagaoglu, Yelda. "Analysis of Pcp-2/L7 gene expression and function." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180545753.

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Brinkmann, Eva-Maria [Verfasser], and Suat [Akademischer Betreuer] Özbek. "Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation / Eva-Maria Brinkmann ; Betreuer: Suat Özbek." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180609794/34.

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Schubert, Antonia. "Wnt-Signalwegsanalysen während der Metastasierung von Mamma-Karzinomen." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7C4D-A.

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Books on the topic "ROR1/2"

1

Dog Squad (Rory Branagan (Detective), Book 2). HarperCollins Publishers Limited, 2018.

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Lazar, Ralph, and Andrew Clover. Rory Branagan : Detective: The Dog Squad #2. Penguin Young Readers Group, 2020.

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3

Atkinson, Barry. Six-Gun Law 2: The Westerns of Rory Calhoun, Rod Cameron, Sterling Hayden and Richard Widmark. Midnight Marquee Press, Inc., 2018.

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Conference papers on the topic "ROR1/2"

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Dave, Hema, Sivasubramanian Baskar, Javed Khan, Alan Wayne, and Christoph Rader. "Abstract 2578: ROR1: A novel target for pre-B acute lymphoblastic leukemia and neuroblastoma." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2578.

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O'Connell, Michael P., Janelle L. Nelson, Jennifer L. Fiori, Sarah S. Subaran, Fred E. Indig, and Ashani T. Weeraratna. "Abstract 2346: Switching from an ROR1-positive phenotype to an ROR2-positive phenotype promotes melanoma progression." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2346.

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Krüger, Stefan, Hannes Hatecke, Heike Billerbeck, Anna Bruns, and Florian Kluwe. "Investigation of the 2nd Generation of Intact Stability Criteria for Ships Vulnerable to Parametric Rolling in Following Seas." In ASME 2013 32nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/omae2013-10353.

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The existing IMO intact stability criteria (IS-Code 2008) do not generally provide sufficient safety against dynamic stability failures such as parametric rolling for modern ships. Therefore, new stability criteria have been developed by IMO / SLF. These so-called Second Generation Stability Criteria shall ensure sufficient dynamic stability. The criteria are structured in a three level approach, where the first level consists of quite simple formulae. If a ship does not pass the first level, it is assumed that the ship is vulnerable to the phenomenon addressed, and the second level of criteri
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Tsujimoto, Masaru, Naoto Sogihara, Mariko Kuroda, and Akiko Sakurada. "Development of a Ship Performance Simulator in Actual Seas." In ASME 2015 34th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/omae2015-41708.

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Greenhouse gas shall be reduced from shipping sector. For that purpose the regulation of EEDI (energy efficiency design index for new ships) and SEEMP (ship energy efficiency management plan) were entry into force from 2013. In order to improve energy efficiency of ships in service it is necessary to predict the fuel consumption in actual seas. In order to reduce GHG emission from ships, a Vessel Performance Simulator in Actual Seas has been developed. It simulates ship speed and fuel consumption at steady condition by using weather data and designated engine revolution. Physical models for hu
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