Academic literature on the topic 'Rosiglitazone'

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Journal articles on the topic "Rosiglitazone"

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Okami, Nobuya, Purnima Narasimhan, Hideyuki Yoshioka, et al. "Prevention of JNK Phosphorylation as a Mechanism for Rosiglitazone in Neuroprotection after Transient Cerebral Ischemia: Activation of Dual Specificity Phosphatase." Journal of Cerebral Blood Flow & Metabolism 33, no. 1 (2012): 106–14. http://dx.doi.org/10.1038/jcbfm.2012.138.

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Rosiglitazone, a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist, prevents cell death after cerebral ischemia in animal models, but the underlying mechanism has not been clarified. In this study, we examined how rosiglitazone protects neurons against ischemia. Mice treated with rosiglitazone were subjected to 60 minutes of focal ischemia followed by reperfusion. Rosiglitazone reduced infarct volume after ischemia and reperfusion. We show that this neuroprotective effect was reversed with a PPARgM antagonist. Western blot analysis showed a significant increase in expressi
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Bogatkevich, Galina S., Kristin B. Highland, Tanjina Akter та Richard M. Silver. "The PPARγAgonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects". Pulmonary Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/545172.

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We present novel data demonstrating that the expression of PPARγis reduced in lung fibroblasts from black SSc-ILD patients as compared to white patients. Activating PPARγwith the agonist rosiglitazone increased the expression of MMP-1 and inhibited collagen type I in lung fibroblasts isolated from white, but not black, SSc-ILD patients. Blocking the c-Met receptor abolishes rosiglitazone's effects on collagen and MMP-1 in lung fibroblasts isolated from white SSc-ILD patients, while augmenting the expression of the c-Met receptor in fibroblasts from black SSc-ILD patients replicates the effects
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Lu, Wenyi, Kaiyan Liu, Weimin Wang, Shujuan Wang, and Yonghuai Feng. "Long-Term Treatment with Rosiglitazone Delays Hematopoietic Recovery in Response to Stress." Blood 126, no. 23 (2015): 4769. http://dx.doi.org/10.1182/blood.v126.23.4769.4769.

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Abstract Rosiglitazone is a peroxisome proliferator activated receptor-γ(PPAR-γ) agonist available to improve glucose metabolism in patients with Type 2 diabetes. Recent evidence suggests that therapeutic use of rosiglitazone have caused unwanted hematological side effects, such as anemia, leukopenia, thrombocytopenia, even pancytopenia. However, others reported that pretreatment with rosiglitazone for 5 days could protect against 5-Fu-induced myelotoxity which is FLT3 dependent. Thus, it is still unclear the exact effects of rosiglitazone treatment on homeostatic and stress hematopoiesis. Ros
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&NA;. "Rosiglitazone." Reactions Weekly &NA;, no. 1180 (2007): 34. http://dx.doi.org/10.2165/00128415-200711800-00107.

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&NA;. "Rosiglitazone." Reactions Weekly &NA;, no. 1186 (2008): 33. http://dx.doi.org/10.2165/00128415-200811860-00106.

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&NA;. "Rosiglitazone." Reactions Weekly &NA;, no. 1127 (2006): 21. http://dx.doi.org/10.2165/00128415-200611270-00070.

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&NA;. "Rosiglitazone." Reactions Weekly &NA;, no. 1143 (2007): 21. http://dx.doi.org/10.2165/00128415-200711430-00070.

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&NA;. "Rosiglitazone." Reactions Weekly &NA;, no. 788 (2000): 9–10. http://dx.doi.org/10.2165/00128415-200007880-00030.

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&NA;. "Rosiglitazone." Reactions Weekly &NA;, no. 788 (2000): 10. http://dx.doi.org/10.2165/00128415-200007880-00031.

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&NA;. "Rosiglitazone." Reactions Weekly &NA;, no. 850 (2001): 11. http://dx.doi.org/10.2165/00128415-200108500-00028.

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Dissertations / Theses on the topic "Rosiglitazone"

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Pereira, Lúciano Artur Lopes. "Characterization of the sympathomimetic action of rosiglitazone." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/53524.

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Pereira, Lúciano Artur Lopes. "Characterization of the sympathomimetic action of rosiglitazone." Dissertação, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/53524.

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Matos, Amélio Fernando de Godoy. "Relação entre a Síndrome Metabólica, teor de gordura intramiocelular e os níveis plasmáticos da Adiponectina: papel da Rosiglitazona." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1421.

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A resistência à insulina está associada com o aumento do teor de gordura intramiocelular (GIMC) e com níveis séricos da adiponectina (ADP) diminuídos. A ADP por sua vez está envolvida na oxidação de gordura muscular. Entretanto, a relação entre ambas continua controversa. O objetivo deste estudo é explorar a relação entre a ADP e a GIMC em adultos não diabéticos, além de estudar o papel da rosiglitasona (RSG) sobre a distribuição da gordura entre os compartimentos musculares. Este estudo compreende duas fases: uma fase transversal (corte-transversal) e uma fase longitudinal, de intervenção ter
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McClure, Lauren Elizabeth. "Best of Both Worlds: Linking Nitric Oxide Donors and Rosiglitazone." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/321882.

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Ali, Tomader Faroug Mohammed. "Protection of pancreatic beta cells by Rosiglitazone : mechanisms and pathways." Thesis, University of Brighton, 2011. https://research.brighton.ac.uk/en/studentTheses/a2865a73-c579-4bf0-a80f-2b609425cc17.

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The thiazolidinedione Rosiglitazone can protect pancreatic beta cells from the detrimental effects of free fatty acids. The aim of this study was to determine the differential effects of saturated fatty acids on beta cells and to identify the mechanisms through which Rosiglitazone can protect beta cell viability. Utilising the mouse beta cell line MIN6, transmission electron microscopy (TEM) was used to determine the effects of palmitate and Rosiglitazone on lipid uptake and cell ultra-structure. H/PI staining and MTT assays were used to determine cell viability.
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Sidhu, Jagdip Singh. "The effects of rosiglitazone, a peroxisome proliferator-activated receptor γ ligand, on atherosclerosis." Thesis, St George's, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407397.

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Ferreira, Iolanda João Mora Cruz de Freitas. "Pre and postjunctional effects of rosiglitazone on the isolated rat aorta and heart." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/61097.

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Ferreira, Iolanda João Mora Cruz de Freitas. "Pre and postjunctional effects of rosiglitazone on the isolated rat aorta and heart." Dissertação, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/61097.

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Dias, Cristiano. "Rosiglitazone pode causar lesão tubular renal em ratos normais mas não em ratos hipercolesterolêmicos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-25022010-160938/.

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Introdução: Rosiglitazone (RGL) é um ligante dos receptores PPAR e vem sendo usada no tratamento do Diabetes Mellitus tipo 2 e nas doenças inflamatórias. Mas, RGL pode reduzir a filtração glomerular (FG), a carga excretada de sódio na urina (UVNa) e aumentar a expressão da Na+,K+- ATPase na medula renal. Então, RGL pode causar edema e insuficiência cardíaca congestiva. Entretanto, não tem sido reportado se RGL pode induzir insuficiência renal aguda (IRA). Objetivo: Verificar se a redução da FG causada pelo tratamento com RGL predispõe à IRA em ratos. Avaliar em condições basais e de vasoconstr
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Woods, Sally. "Comparison of metformin, rosiglitazone, and acetaminophen in the prevention of olanzapine toxicity in mice." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1305892985.

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Books on the topic "Rosiglitazone"

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Parker, Philip M., and James N. Parker. Rosiglitazone: A medical dictionary, bibliography, and annotated research guide to Internet references. ICON Health Publications, 2004.

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Canadian Coordinating Office for Health Technology Assessment., ed. Comparative clinical and budget evaluations of rosiglitazone and pioglitazone with other anti-diabetic agents. Canadian Coordinating Office for Health Technology Assessment, 2003.

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Pharm, Boucher Michel B., and Canadian Coordinating Office for Health Technology Assessment., eds. Efficacy of rosiglitazone and pioglitazone compared to other anti-diabetic agents: Systematic review and budget impact analysis. Canadian Coordinating Office for Health Technology Assessment, 2002.

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Pharm, Boucher Michel B., and Canadian Coordinating Office for Health Technology Assessment., eds. Efficacy of rosiglitazone and pioglitazone compared to other anti-diabetic agents: Systematic review and budget impact analysis. Canadian Coordinating Office for Health Technology Assessment, 2002.

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HOPPE, Joyce. Avandia Rosiglitazone. Independently Published, 2018.

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Kayla, Carl. Avandia Rosiglitazone. Independently Published, 2018.

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Blokdijk, G. J. Rosiglitazone Maleate; Complete Self-Assessment Guide. CreateSpace Independent Publishing Platform, 2018.

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Rosiglitazone - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References. ICON Health Publications, 2004.

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Duplisea, J. Kevin. A pilot study to describe the efficacy of metformin versus rosiglitazone in HIV patients receiving protease inhibitors. 2003.

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Book chapters on the topic "Rosiglitazone"

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Uçmak, Gülin, and Burcu Esen Akkaş. "Rosiglitazone Effect on Radioiodine Uptake in a Case of Dedifferentiated Thyroid Carcinoma." In Thyroid and Parathyroid Diseases. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-78476-2_47.

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Sahin, Ali. "Insulin-Sensitizing Antihyperglycemic Drugs." In Current Perspective on Diabetes Mellitus in Clinical Sciences. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359111.10.

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Insulin-sensitizing antihyperglycemic drugs are a class of medications used in the management of diabetes mellitus, particularly type 2 diabetes, by improving the body’s response to insulin. One prominent group within this category is the thiazolidinediones (TZDs), which include drugs like pioglitazone and rosiglitazone. These medications act primarily by activating peroxisome proliferator-activated receptor gamma (PPARγ) receptors, which play a key role in regulating glucose and lipid metabolism. By enhancing insulin sensitivity in peripheral tissues such as muscle, adipose tissue, and liver,
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Meisner, F., A. Noack, A. Cihlar, et al. "Rosiglitazon stabilisiert atherosklerotische Plaques." In Chirurgisches Forum 2006. Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-34668-6_153.

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Day, Caroline, and Clifford J. Bailey. "Rosiglitazone." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.62558-9.

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Day, C., and C. J. Bailey. "Rosiglitazone☆." In Reference Module in Biomedical Sciences. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-801238-3.97237-4.

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"Rosiglitazone." In Hale’s Medications & Mothers’ Milk™ 2019. Springer Publishing Company, 2018. http://dx.doi.org/10.1891/9780826150356.0913.

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"Rosiglitazone (r)." In Drugs Handbook 2012–2013. Bloomsbury Academic, 2011. http://dx.doi.org/10.5040/9781350363595.art-1531.

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Patti, Mary-Elizabeth, Mark Callery, Robert Najarian, et al. "Case 93: Progressive Hypoglycemia Due to Insulinoma in a Patient with Type 2 Diabetes: Treatment with Image-Guided Minimally Invasive Pancreas-Sparing Surgery." In Diabetes Case Studies: Real Problems, Practical Solutions. American Diabetes Association, 2015. http://dx.doi.org/10.2337/9781580405713.93.

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A 54-year-old man with type 2 diabetes (T2D) presented for evaluation of hypoglycemia. T2D was diagnosed at age 35 years, when the patient presented with recurrent urinary tract infections. Treatment with diet, metformin, and pioglitazone/rosiglitazone led to normalization of glucose, with hemoglobin A1c of 6%. He remained stable until age 54 years, when he developed an inferior wall myocardial infarction (MI). Postinfarction pericarditis required initiation of higher dose aspirin (650 mg t.i.d.). Patient markedly improved diet and increased exercise in the post-MI setting, achieving a rapid 2
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Jimenez-Serrania, Maria-Isabel. "Data Mining Strategy to Prevent Adverse Drug Events: The Cases of Rosiglitazone and COVID-19 Vaccines." In Research Advances in Data Mining Techniques and Applications [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.112412.

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This chapter analyzes how a simple strategy of early detection of safety signals using data mining can prevent the potential risk of adverse events with new or former drugs. We first present the case of an active antidiabetic ingredient, rosiglitazone. The capability of the strategy to detect the risk of heart failure among the data reported during the first 8 years of commercialization was demonstrated 2 years before rosiglitazone was withdrawn from the market in 2020 due to that risk. Ten years later, agility in obtaining safety signals after marketing a drug was put to the test with COVID-1
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Tzimopoulou Sofia, Cunningham Vincent J., Nichols Thomas E., et al. "Validation and Pilot Application of [." In Advances in Alzheimer’s Disease. IOS Press, 2011. https://doi.org/10.3233/978-1-60750-793-2-627.

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Here we describe methods for application of quantitative fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) measures of brain glucose metabolism in multi-centre clinical trials for Alzheimer's disease. We validated methods and demonstrated their use in the context of a treatment trial with the PPARγ agonist Rosiglitazone XR versus placebo in mild to moderate AD patients. Novel quantitative indices related to the combined forward rate constant for [18F]FDG uptake \(({K}_{i}^{index})\) and to the rate of cerebral glucose utilization \((CM{R}_{glu}^{index})\) were applied. A
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Conference papers on the topic "Rosiglitazone"

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Cugno, Chiara, Ganesh Halade, and Md Mizanur Rahman. "Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging mice." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0099.

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Rosiglitazone is an effective insulin-sensitizer, however, associated with bone loss mainly due to increased bone resorption, and bone marrow adiposity, and decreased bone formation. We investigated the effect of the co-administration of fish oil (FO) rich in omega-3 fatty acids (FAs) on rosiglitazone (RSG)-induced bone loss in aging C57BL/6 mice and the mechanisms underlying potential preventive effect. Mice fed the iso-caloric diet supplemented with fish oil exhibited significantly higher levels of bone density in different regions compared to the other groups. In the same cohort of mice, re
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Song, Eun-Kee, Ho-Young Yhim, Jun-Mo Yim, et al. "Abstract 4413: Rosiglitazone prevents graft-versus-host disease (GVHD)." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4413.

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Benkő, Klára, Éva Pintye, Boglárka Szabó, et al. "Effect of Rosiglitazone on Radiation Damage in Bone Marrow Hemopoiesis." In RADIATION DAMAGE IN BIOMOLECULAR SYSTEMS: Proceedings of the 5th International Conference (RADAM 2008). AIP, 2008. http://dx.doi.org/10.1063/1.3058979.

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Ward, JE, J. Tran, SR Foster, SG Royce, ML Tang та SR Bailey. "Bronchodilator Actions of Rosiglitazone in Isolated Mouse Trachea Are PPARγ-Independent." У American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2432.

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Silva, AG, DM Laks, CB Magalhaes, et al. "Pulmonary Effects of Rosiglitazone in Rats Treated with Isoproterenol for One Week." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6070.

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Bourke, Jane E., James Esposito, Yan Bai, and Mike Sanderson. "Rosiglitazone Inhibits Small Airway Contraction And Calcium Signalling In Mouse Lung Slices." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1262.

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Tabuso, Maria, Raghu Adya, Mark Christian, and Ramesh P. Arasaradnam. "PWE-056 Rosiglitazone: a potential new stroma targeted therapeutic agent in colon cancer." In British Society of Gastroenterology Annual Meeting, 17–20 June 2019, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2019. http://dx.doi.org/10.1136/gutjnl-2019-bsgabstracts.380.

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Sakurai, R., E. Shin, J. Corral, J. Torday та V. Rehan. "Antenatal Administration of PPARγ Agonist Rosiglitazone (RGZ) Prevents Hyperoxia-Induced Lung Injury Postnatally." У American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2643.

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Oberlick, Elaine, LaTonia D. Taliaferro-Smith, Wayne Harris, et al. "Abstract 1078: Rosiglitazone inhibits breast cancer growth and proliferation via cyclin D1 inhibition." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1078.

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Ibrahim, Khadega, Chiara Cugno, and Md Mizanur Rahman. "Conjugated Linoleic Acid (CLA) co-treatment alleviates antidiabetic drug, rosiglitazone associated deterioration of bone remodeling." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0148.

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Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to decreased insulin secretion, defective action or both. The rosiglitazone (RSG) is one of the oral antidiabetic drug used in type 2 (T2) DM and has a unique insulin-sensitizing capacity. However, RSG has a negative side effect on the bone as it stimulates the differentiation of bone marrow-mesenchymal stromal cells (BM-MSCs) into adipocytes at the expense of osteoblasts in the bone marrow microenvironment, disturbing the normal balance of bone remodeling and causing BM adiposity. On the other hand, the t
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