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Dissertations / Theses on the topic 'Rosiglitazone'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Pereira, Lúciano Artur Lopes. "Characterization of the sympathomimetic action of rosiglitazone." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/53524.

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2

Pereira, Lúciano Artur Lopes. "Characterization of the sympathomimetic action of rosiglitazone." Dissertação, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/53524.

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3

Matos, Amélio Fernando de Godoy. "Relação entre a Síndrome Metabólica, teor de gordura intramiocelular e os níveis plasmáticos da Adiponectina: papel da Rosiglitazona." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1421.

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A resistência à insulina está associada com o aumento do teor de gordura intramiocelular (GIMC) e com níveis séricos da adiponectina (ADP) diminuídos. A ADP por sua vez está envolvida na oxidação de gordura muscular. Entretanto, a relação entre ambas continua controversa. O objetivo deste estudo é explorar a relação entre a ADP e a GIMC em adultos não diabéticos, além de estudar o papel da rosiglitasona (RSG) sobre a distribuição da gordura entre os compartimentos musculares. Este estudo compreende duas fases: uma fase transversal (corte-transversal) e uma fase longitudinal, de intervenção ter

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4

McClure, Lauren Elizabeth. "Best of Both Worlds: Linking Nitric Oxide Donors and Rosiglitazone." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/321882.

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5

Ali, Tomader Faroug Mohammed. "Protection of pancreatic beta cells by Rosiglitazone : mechanisms and pathways." Thesis, University of Brighton, 2011. https://research.brighton.ac.uk/en/studentTheses/a2865a73-c579-4bf0-a80f-2b609425cc17.

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The thiazolidinedione Rosiglitazone can protect pancreatic beta cells from the detrimental effects of free fatty acids. The aim of this study was to determine the differential effects of saturated fatty acids on beta cells and to identify the mechanisms through which Rosiglitazone can protect beta cell viability. Utilising the mouse beta cell line MIN6, transmission electron microscopy (TEM) was used to determine the effects of palmitate and Rosiglitazone on lipid uptake and cell ultra-structure. H/PI staining and MTT assays were used to determine cell viability.

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6

Sidhu, Jagdip Singh. "The effects of rosiglitazone, a peroxisome proliferator-activated receptor ÃŽÂ³ ligand, on atherosclerosis." Thesis, St George's, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407397.

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7

Ferreira, Iolanda João Mora Cruz de Freitas. "Pre and postjunctional effects of rosiglitazone on the isolated rat aorta and heart." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/61097.

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Ferreira, Iolanda João Mora Cruz de Freitas. "Pre and postjunctional effects of rosiglitazone on the isolated rat aorta and heart." Dissertação, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/61097.

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9

Dias, Cristiano. "Rosiglitazone pode causar lesão tubular renal em ratos normais mas não em ratos hipercolesterolêmicos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-25022010-160938/.

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Introdução: Rosiglitazone (RGL) é um ligante dos receptores PPAR e vem sendo usada no tratamento do Diabetes Mellitus tipo 2 e nas doenças inflamatórias. Mas, RGL pode reduzir a filtração glomerular (FG), a carga excretada de sódio na urina (UVNa) e aumentar a expressão da Na+,K+- ATPase na medula renal. Então, RGL pode causar edema e insuficiência cardíaca congestiva. Entretanto, não tem sido reportado se RGL pode induzir insuficiência renal aguda (IRA). Objetivo: Verificar se a redução da FG causada pelo tratamento com RGL predispõe à IRA em ratos. Avaliar em condições basais e de vasoconstr

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10

Woods, Sally. "Comparison of metformin, rosiglitazone, and acetaminophen in the prevention of olanzapine toxicity in mice." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1305892985.

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11

Ait, Benichou Siham. "Étude de la régulation des canaux potassiques ROMK1 par un antidiabétique, la rosiglitazone implication des PPARgamma." Mémoire, Université de Sherbrooke, 2011. http://savoirs.usherbrooke.ca/handle/11143/4079.

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Les thiazolidinediones (TZDs) sont des médicaments antidiabétiques (agonistes des récepteurs nucléaires de type PPAR[gamma]) utilisés au cours des dix dernières années pour le traitement du diabète de type II. Malheureusement leur utilisation peut provoquer, chez certains patients, une rétention accrue de fluides et une formation d?oedèmes rénaux. Des études récentes suggèrent l'implication d'un canal sodique épithélial (ENaC), exprimé au niveau du tubule collecteur rénal, dans ces effets secondaires. En effet, la stimulation des PPAR[gamma] par les TZDs activent les canaux sodiques épithéliau

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12

Oliveira, Katharina Morant Holanda de. "Administração sistêmica de rosiglitazona estimula a apoptose de osteócitos e cementócitos, interferindo no desenvolvimento de lesões periapicais induzidas em camundongos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/58/58135/tde-27022018-152210/.

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O tecido ósseo é um tipo especializado de tecido conjuntivo que desempenha funções essenciais para a sobrevivência do indivíduo, sendo composto predominantemente por osteócitos. Dentre os tecidos mineralizados do corpo, o cemento é um dos menos estudados e compreendidos. A apoptose em células do tecido ósseo têm sido relatada após o uso de Tiazolidinedionas (TZD), uma classe de medicamentos utilizada no tratamento do diabetes melitus tipo 2, representadas pela Rosiglitazona. Assim, os objetivos desse estudo foram: avaliar, in vivo, um protocolo de administração sistêmica da Rosiglitazona em ca

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13

Thaker, Rajsi Y. "Potential drug treatment for Duchenne muscular dystrophy which could be through upregulation of lipin1." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1629996330644397.

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14

Spaeth, Brianne, and Barbara Fontana. "A Cost-Effectiveness Analysis Comparing Glargine Versus Rosiglitazone or Pioglitazone for Patients Failing Metformin Plus a Sulfonylurea." The University of Arizona, 2008. http://hdl.handle.net/10150/624269.

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Class of 2008 Abstract<br>Objectives: To determine the cost-effectiveness of adding a thiazolidinedione (TZD) versus insulin glargine (glargine) as a triple regimen for treatment of Type 2 diabetes mellitus for patients not controlled with metformin and a sulfonylurea. Methods: A decision analytic model was developed to compare the clinical outcomes and costs of triple therapy with either a TZD or glargine. Published literature was used to determine treatment efficacy and the frequency of clinically important adverse effects. Cost data were obtained from the 2007 Physician Fee Reference and N

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15

Grenier, Audrey. "Effets de la rosiglitazone sur la distribution adipeuse et la variabilité de la fréquence cardiaque chez des patients diabétiques de type 2 avec pontage aorto-coronarien." Master's thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/25552.

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L’obésité abdominale est un facteur de risque des maladies cardiovasculaires et englobe le tissu adipeux viscéral (TAV) et le tissu adipeux sous-cutané (TASC). Une augmentation de TAV est associée à une diminution de la variabilité de la fréquence cardiaque, représentant l’équilibre du système nerveux autonome, ainsi qu’à une augmentation des risques d’évènements cardiovasculaires. Par contre, l’impact d’une augmentation du TASC sur la variabilité de la fréquence cardiaque n’est pas documenté. La rosiglitazone, un antidiabétique oral, entraine une augmentation du poids corporel préférentiellem

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16

François, Mathias. "Effets anti-interleukine 1beta in vitro des ligands des récepteurs Activés par les proliférateurs de péroxysomes (PPARs) dans les chondrocytes articulaires : analyse des mécanismes d'action moléculaires." Paris 6, 2004. http://www.theses.fr/2004PA066120.

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17

Landy, Caroline. "Mechanisms of action of rosiglitazone in the protection of pancreatic beta cells from free fatty acid induced damage." Thesis, University of Brighton, 2011. https://research.brighton.ac.uk/en/studentTheses/ab4e94da-07ce-46c6-bd1e-aa6d89a4ba02.

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A wealth of recent evidence implicates increasing obesity levels in the rising global epidemic of type 2 diabetes. At a cellular level, high fatty acid concentrations contribute to increasing p-cell dysfunction and eventual p-cell failure. We have shown that the thiazolidinedione (TZD) rosiglitazone has direct effects on pancreatic p-cell function. The aim of this study was to determine the cell signalling molecules mediating these effects, and to test the hypothesis that rosiglitazone can protect pancreatic p-cells from the detrimental effects of free fatty acids. Utilising the mouse p-cell l

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18

Tungsiripat, Marisa. "Changes in Peripheral Lipoatrophy, Surrogate Markers of Cardiovascular Disease, and Mitochondria after Rosiglitazone in HIV-infected individuals with Lipoatrophy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1309964773.

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19

Calixto, Leandro Augusto. "Métodos de análise da rosiglitazona e pioglitazona e de seus principais metabólitos: aplicações em estudos de metabolismo in vitro." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-29062012-134429/.

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Estudos de metabolismo in vitro possuem o intuito de caracterizar e quantificar possíveis metabólitos, elucidar as vias metabólicas e sugerir modelos a serem seguidos para a realização de estudos in vivo. Com o intuito de estudar o metabolismo in vitro não estereosseletivo da rosiglitazona (RSG) empregando fração microssomal de fígado de ratos,foi desenvolvida uma metodologia por cromatografia líquida de alta eficiência (HPLC) com detecção UV em 245 nm, para analisar a RSG e seus principais metabólitos, p-hidroxi rosiglitazona (?-OH-R) e N-desmetil rosiglitazona (N-Dm-R). Os analitos foram sep

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20

Rautio, K. (Katriina). "Effects of insulin-lowering drugs in PCOS: endocrine, metabolic and inflammatory aspects." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:951428268X.

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Abstract Most women with polycystic ovary syndrome (PCOS) exhibit features of metabolic syndrome, including insulin resistance, abdominal obesity, dyslipidaemia, glucose intolerance and low-grade chronic inflammation, reflected in elevated levels of serum C-reactive protein (CRP), placing these women at increased risk of cardiovascular disease and type 2 diabetes (type 2 DM). The aim of this study was to investigate the effects of two well-known insulin-lowering drugs used in the treatment of type 2 DM, metformin and rosiglitazone, on traditional cardiovascular risk factors and inflammation i

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21

Lessard, Sarah, and not supplied. "Therapeutic interventions for lipidinduced insulin resistance in skeletal muscle: mechanisms of action." RMIT University. Medical Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20070205.101938.

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It has long been known that in addition to disruptions in glucose homeostasis, individuals with insulin resistance have a breakdown in lipid dynamics, often manifested by elevated levels of circulating fatty acids (FA) together with accumulation of lipids in insulin-sensitive tissues, including skeletal muscle. However, little is known about how common therapies used to treat insulin resistant individuals (such as Rosiglitazone and exercise training) improve skeletal muscle lipid and glucose metabolism. Thus, the primary aim of the studies undertaken for this thesis was to enhance

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22

Caddy, Joanne. "The non-genomic effects of the PPAR-γ ligand rosiglitazone on intracellular calcium concentrations in mammalian monocytic and smooth muscle cells". Thesis, Cardiff Metropolitan University, 2010. http://hdl.handle.net/10369/921.

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Thiazolidinediones such as rosiglitazone are used in the treatment of Type-2 Diabetes, and are ligands for peroxisome proliferator-activated receptor-gamma (PPARγ), a ligand-activated transcription factor that regulates expression of genes involved in glucose and lipid metabolism. However, rosiglitazone is known to exert PPARγ-independent effects alongside its classical receptor-dependent effects. This study investigated the PPARγ-independent effects of rosiglitazone on intracellular calcium (Ca2+i) signalling in cultured monocytic and vascular smooth muscle cells Rosiglitazone rapidly (5-30mi

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23

Richette, Pascal. "Effets anti-interleukine 1β in vitro des œstrogènes et de la rosiglitazone dans les chondrocytes articulaires : analyse des mécanismes d'action moléculaires". Paris 7, 2003. http://www.theses.fr/2003PA077180.

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24

Asp, Michelle Lynn. "Therapeutic Strategies for the Treatment of Insulin Resistance in Various Metabolic Disease States." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1280255826.

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25

Sharma, Ajaykumar Narayan. "Impact of Insulin Resistance on Behavioral and Neurochemical Deficits in db/db Mice." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1321454576.

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26

Barlow, Jonathan David. "Effectiveness of rosiglitazone in reducing flexion contracture in a novel rabbit model of arthrofibrosis with surgical capsular release| a biomechanical, histological, and genetic analysis." Thesis, College of Medicine - Mayo Clinic, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1541020.

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<p> <b>Introduction:</b> Animal models of joint contracture induced by capsular injury and prolonged immobilization are used to elucidate the mechanisms of arthrofibrosis. Clinically, patients with joint contracture commonly undergo surgical capsular release. Peroxisome proliferator-activated receptor gamma (PPARγ) agonists (such as rosiglitazone) hold promise as antifibrogenic agents that may be used as an adjunct to capsular release. </p><p> <b>Methods:</b> A surgically induced capsular contracture was created in thirty skeletally mature female rabbits. Twenty rabbits underwent a lim

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27

Laporte, Franck. "Traitement et perspectives de traitement du diabète de type II." Bordeaux 2, 2000. http://www.theses.fr/2000BOR2P089.

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28

Santos, Caroline Fernandes dos. "Agonistas PPAR (Rosiglitazona, Bezafibrato e Fenofibrato) e alterações bioquímicas e estruturais em órgãos-alvo de camundongos C57BL/6 alimentados com dieta hiperlipídica rica em sacarose." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2857.

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Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro<br>Este trabalho teve o objetivo de estudar o efeito de medicamentos com diferentes ações agonista PPAR (rosiglitazona, fenofibrato e bezafibrato) sobre o perfil lipídico, glicídico e alterações na massa corporal e morfologia do tecido adiposo e pancreático em modelo de diabetes e sobrepeso induzido por dieta. Camundongos C57BL/6 (2 meses de idade) foram alimentados com dieta padrão (SC, n=10) ou dieta hiperlipídica rica em sacarose (HFHS, n=40) por 6 semanas. Logo após, os animais HFHS foram subdividos em: HFHS não

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29

Brackenridge, Anna. "The effect of thiazolidinediones on lipoprotein metabolism : a double blind randomised placebo controlled trial using stable isotopes to investigate the effect of pioglitazone, rosiglitazone and placebo on lipoprotein (apolipoprotein B100, VLDL, IDL and LDL) metabolism." Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/843498/.

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30

Laudenberg, Markus. "Rosiglitazon in der Therapie des HIV-assoziierten Lipodystrophie-Syndroms: eine prospektive Studie." Aachen Shaker, 2009. http://d-nb.info/997919418/04.

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31

Tombou, Noumbi Pierre Patrick [Verfasser], Bibra Helene [Akademischer Betreuer] von, Johann Josef [Akademischer Betreuer] Hauner, and Petra-Maria [Akademischer Betreuer] Schumm-Draeger. "Die subklinische diastolische Dysfunktion bei Patienten mit Typ 2 Diabetes kann mittels Gewebedoppler quantifiziert werden mit dem Potential der Verlaufskontrolle bei präventiver Therapie am Beispiel zweier Pilotstudien mit Ramipril und Rosiglitazone / Pierre Patrick Tombou Noumbi. Gutachter: Johann Josef Hauner ; Petra-Maria Schumm-Draeger. Betreuer: Helene von Bibra." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1031075518/34.

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32

Lalli, Cristina Alba. "Efeito da rosiglitazona e da lovastatina na resistencia insulinica da dieta hiperlipidica." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311224.

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Orientador: Mario Jose Abdalla Saad<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-10T01:17:39Z (GMT). No. of bitstreams: 1 Lalli_CristinaAlba_D.pdf: 9125967 bytes, checksum: 5ab6be7c7ee8bef63c8acdec567c428b (MD5) Previous issue date: 2007<br>Resumo: A insulina é o principal hormônio anabólico, que atua através da ativação de transportadores, regulação de enzimas e expressão de genes que codificam enzimas envolvidas na captação e armazenamento de substratos. Para exercer suas ações, a insulina emprega duas vias pr

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33

Torres, Rogil José de Almeida [UNIFESP]. "Avaliação das anormalidades precoces esclerocoriorretinianas observadas em coelhos hipercolesterolemicos tratados com Rosiglitazona." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9053.

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Made available in DSpace on 2015-07-22T20:49:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-04-28<br>O objetivo deste trabalho é avaliar as anormalidades da esclera, coroide e retina de coelhos induzidas pela dieta hipercolesterolêmica, além da possibilidade de prevenção dessas anormalidades com administração sistêmica de rosiglitazona. Para isto, 54 coelhos new zealand foram distribuídos em quatro grupos: grupo-controle (GC) recebeu dieta normal; grupo 1 recebeu dieta hipercolesterolêmica; grupo 2 recebeu dieta hipercolesterolêmica associada à administração diária de 3 mg de ros

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Batista, José Gomes [UNIFESP]. "Efeitos clínicos, endócrinos e metabólicos da rosiglitazona na síndrome dos ovários policísticos." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9388.

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Made available in DSpace on 2015-07-22T20:49:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-04-29. Added 1 bitstream(s) on 2015-08-11T03:25:42Z : No. of bitstreams: 1 Publico-095b.pdf: 1249697 bytes, checksum: 8c8ce9855784ad0a5e4eeb7a1f312da1 (MD5). Added 1 bitstream(s) on 2015-08-11T03:25:42Z : No. of bitstreams: 2 Publico-095b.pdf: 1249697 bytes, checksum: 8c8ce9855784ad0a5e4eeb7a1f312da1 (MD5) Publico-095c.pdf: 915902 bytes, checksum: 72ec65580d60438f4e985c3ef18b5040 (MD5)<br>O presente estudo tem como objetivo avaliar, em pacientes com a síndrome dos ovários policísticos,

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Lima, Caroline Lourenço de. "Análise dos efeitos de agonistas dos PPARγ e PPARβ/δ sobre aspectos celulares e moleculares relacionados com a resposta inflamatória e com reparo em células da polpa dentária humana". reponame:Repositório Institucional da UnB, 2017. http://repositorio.unb.br/handle/10482/24083.

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Tese (doutorado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2017.<br>Texto parcialmente disponibilizado pelo autor. Conteúdo restrito: Apêndices.<br>Submitted by Raquel Almeida (raquel.df13@gmail.com) on 2017-07-26T15:02:39Z No. of bitstreams: 1 2017_DonaldManigat_PARCIAL.pdf: 621102 bytes, checksum: 1f0b1edf50dddf5686b5208b044257b7 (MD5)<br>Approved for entry into archive by Raquel Viana (raquelviana@bce.unb.br) on 2017-08-11T18:31:27Z (GMT) No. of bitstreams: 1 2017_DonaldManigat_PARCIAL.pdf: 621102 bytes, checksum: 1f0b1edf50ddd

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Laudenberg, Markus [Verfasser]. "Rosiglitazon in der Therapie des HIV-assoziierten Lipodystrophie-Syndroms: Eine prospektive Studie / Markus Laudenberg." Aachen : Shaker, 2009. http://d-nb.info/1159836388/34.

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Libório, Alexandre Braga. "Rosiglitazona, agonista do PPAR-y \"Peroxisome Proliferator-Activated Receptor-y\" reverte a nefrotoxicidade induzida pelo tenofovir-DF." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-12092008-130850/.

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Introdução: A nefrotoxicidade dos antiretrovirais constituem atualmente fator importante na morbidade e mortalidade de pacientes com HIV. O tenofovir DF (TDF) se enquadra em um dos antiretrovirais mais lesivos ao rim. Conhecer seu mecanismo de nefrotoxicidade e estudar medidas protetoras podem melhorar seu uso clínico. Material e Métodos: Ratos foram tratados durante 30 dias com uma de duas doses de TDF (50 ou 300mg/Kg de dieta), sendo que um grupo teve adicionado em sua dieta maleato de rosiglitazona (RSG) na dose de 92mg/Kg de dieta nos últimos 15 dias. Após esse período, os ratos foram colo

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Milton, Flora Aparecida. "Avaliação do perfil de expressão gênica modulado pelo GQ-16 em adipócitos 3T3-L1 utilizando a técnica de microarranjo." reponame:Repositório Institucional da UnB, 2015. http://dx.doi.org/10.26512/2015.02.T.18077.

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Tese (doutorado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Prorgama de Pós-Graduação em Ciências da Saúde, 2015.<br>Submitted by Ana Cristina Barbosa da Silva (annabds@hotmail.com) on 2015-03-26T16:34:53Z No. of bitstreams: 1 2015_FloraAparecidaMilton.pdf: 14443405 bytes, checksum: 2f69813bfbeca0cccbad7f9286096b83 (MD5)<br>Approved for entry into archive by Ruthléa Nascimento(ruthleanascimento@bce.unb.br) on 2015-05-04T13:51:55Z (GMT) No. of bitstreams: 1 2015_FloraAparecidaMilton.pdf: 14443405 bytes, checksum: 2f69813bfbeca0cccbad7f9286096b83 (MD5)<br>Made available in DSpa

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Murro, Ada Leticia Barbosa. "Efeitos da rosiglitazona sobre marcadores de risco cardiovascular e função da celula beta em diabeticos tipo 2 virgens de tratamento." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310702.

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Orientador: Marcos Antonio Tambascia<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-10T07:54:38Z (GMT). No. of bitstreams: 1 Murro_AdaLeticiaBarbosa_M.pdf: 2083799 bytes, checksum: 96b1643449081526943a964fd9850136 (MD5) Previous issue date: 2007<br>Resumo: A principal causa de mortalidade entre os portadores de Diabetes tipo 2 é a doença cardiovascular. Estudos têm cada vez mais procurado alterações inerentes ao diabetes tipo 2 que justifiquem a maior incidência de doença cardiovascular nesse grupo. A prese

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Soares, Sara Isabel Marques Mota. "Alertas de segurança : impacto no consumo de medicamentos em Portugal." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/14076.

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Mestrado em Biomedicina Farmacêutica<br>Este estudo teve como objetivos a recolha e análise dos alertas de segurança a medicamentos publicados em Portugal, bem como avaliar o impacto dos alertas de segurança para medicamentos contendo rosiglitazona como substância ativa nas vendas de antidiabéticos em Portugal. Foi conduzida uma pesquisa dos alertas de segurança publicados pelo INFARMED, I.P. e pela EMA, complementada pela análise dos alertas publicados nos Boletins de Farmacovigilância. Para o estudo do impacto dos alertas da rosiglitazona desenhou-se um modelo de análise de regressão segmen

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Werner, Marc Verfasser], and Michael [Akademischer Betreuer] [Böhm. "Untersuchungen zum Einfluss des PPARgamma-Agonisten Rosiglitazon auf die Apoptose isolierter neonataler Kardiomyozyten bei Hypoxie/Reoxygenierung / Marc Werner. Betreuer: Michael Böhm." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052222668/34.

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Blumentrath, Jörg. "Wirkung von RAR- und RXR-Agonisten (Retinoiden) und einem PPAR[gamma]-Agonisten (Rosiglitazon) auf die Insulinsekretion, Proliferation und GLUT2 von INS-1-Zellen /." [S.l.] : [s.n.], 1999. http://www.gbv.de/dms/bs/toc/305260308.pdf.

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Acosta, Castillo Luis Enrique, and Huayhuas Felipe Ramírez. "Desarrollo y validación prospectiva del método de análisis de valoración de glimipiride 2 mg/rosiglitazona 4 mg tabletas recubiertas por cromatografía líquida de alta performance." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2007. https://hdl.handle.net/20.500.12672/2254.

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El presente trabajo desarrolla la validación prospectiva de una forma farmacéutica sólida cuyos principios activos contenidos son Rosiglitazona y Glimepiride, de tal modo que se demostró y estableció evidencia documentada que el proceso de análisis cumple de manera robusta y repetitiva lo que estaba previsto basado protocolo planificado, llamado protocolo de validación, obtenido de la secuencia de desarrollo del nuevo producto y de la metodología de análisis. En la parte inicial de este trabajo se procede a recopilar toda la información bibliografica necesaria para luego proceder con los prim

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Lima, Caroline Lourenço de. "Efeitos da rosiglitazona, agonista do receptor gama ativado por proliferadores peroxissomais, sobre a proliferação e expressão do TGFb1 em cultura primária de células da polpa dentária humana." reponame:Repositório Institucional da UnB, 2012. http://repositorio.unb.br/handle/10482/12589.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2012.<br>Submitted by Albânia Cézar de Melo (albania@bce.unb.br) on 2013-02-28T15:47:52Z No. of bitstreams: 1 2012_CarolineLourencoLima.pdf: 3670076 bytes, checksum: 83cef17097589e82ec83d1df070b5a90 (MD5)<br>Approved for entry into archive by Guimaraes Jacqueline(jacqueline.guimaraes@bce.unb.br) on 2013-03-25T15:23:36Z (GMT) No. of bitstreams: 1 2012_CarolineLourencoLima.pdf: 3670076 bytes, checksum: 83cef17097589e82ec83d1df070b5a90 (MD5)<br>Made available in DSpa

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Siam, Laila. "Rosiglitazon reduziert MMP-9 Serumspiegel bei Patienten mit Diabetes mellitus Typ 2 und koronarer Herzerkrankung: prospektive Studie an 40 Patienten mit Diabetes mellitus Typ 2 und koronarer Herzerkrankung." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-55778.

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Yu, Neng-Chang, and 游能昌. "Development and Application of Rosiglitazone Containing Hydrogels." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/31820677302152359037.

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碩士<br>國立中興大學<br>化學系所<br>104<br>Thiazolidinedione drugs (TZDs) are the only current antidiabetic agents that function primarily by increasing insulin sensitivity. TZDs were first reported as insulin-sensitizing drugs in the early 1980s, but their mechanism remained a mystery until the mid-1990s, when they were found to be ligands for the nuclear receptor transcription factor PPARγ. Molecular compounds such as the clinically available rosiglitazone and pioglitazone have been designed to target PPARγ and for the oral treatment of type 2 Diabetes. However, in addition to attenuating inflammation a

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Perampaladas, Kumar. "Effects of Rosiglitazone on Nitrolgycerin-induced Endothelial Dysfunction." Thesis, 2010. http://hdl.handle.net/1807/24272.

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Sustained nitroglycerin (GTN) therapy impairs endothelial function in healthy volunteers and patients with cardiovascular disease, caused by an increase in vascular oxidative stress. This study aims to estimate the effect of rosiglitazone on vascular endothelial function in healthy volunteers continuously dosed to transdermal GTN (0.6mg/hr) for 7 days. To assess endothelial function, forearm blood flow was measured by venous occlusion strain-gauge plethysmography in response to intra-brachial infusions of acetylcholine. GTN-treated subjects experienced significant attenuation of endothelium-de

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HSU, MING-JOU, and 許敏柔. "To explore the synergy between ENERGI and Rosiglitazone." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/p4gps9.

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碩士<br>輔仁大學<br>生命科學系碩士班<br>106<br>英文摘要 Diabetes is an increasingly common chronic disease worldwide, and it has been confirmed in trampolines that thiazolidinediones can improve insulin sensitivity in patients with insulin resistance, but have been found to have side effects like hepatotoxicity. ENERGI is a novel AMPK activator discovered in our laboratory. It is a water-soluble small molecular compound. By increasing the activity of activated AMPK, it can inhibit the activity of transcription factors in fat cells and the differentiation of adipocytes. The aim of this research is to explore the

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Chen, Yu-Ju, and 陳怡如. "ERK-1/-2 Dependent Induction of Mesangial Cell Differentiation by Rosiglitazone." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/04788627072888173466.

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碩士<br>臺北醫學大學<br>生物醫學技術研究所<br>91<br>Rosiglitazone is a peroxisome proliferator-activated receptor-gamma (PPAR-g) agonist that has been shown to halt mesangium expansion in experimental models of type 2 diabetes mellitus. In the present study, rat mesangial cells were treated with rosiglitazone and its molecular mechanisms coupling growth arrest were examined. Treatment of rat mesangial cells with rosiglitazone resulted in reduction of viable cells and inhibition of [3H] thymidine incorporation. Treatment with rosiglitazone increased the expression of CDK inhibitor, p21CIP-1, which was associate

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Chang, Jen-Chieh, and 張仁杰. "The Studies of Rosiglitazone on Insulin Secretion in Perfused Rat Pancreas." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/18238229110852275121.

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