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Journal articles on the topic 'Rosuvastatin calcium'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Cada, Dennis J., Terri Levien, and Danial E. Baker. "Rosuvastatin Calcium." Hospital Pharmacy 39, no. 1 (2004): 52–68. http://dx.doi.org/10.1177/001857870403900107.

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2

Quirk, Jeremy, Mark Thornton, and Peter Kirkpatrick. "Rosuvastatin calcium." Nature Reviews Drug Discovery 2, no. 10 (2003): 769–70. http://dx.doi.org/10.1038/nrd1205.

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3

Pawar, Prajakta Arun, Vivek Ranjan Sinha, and Ashok Kumar Yadav. "Compatibility Study and Solid Dose Formulation of Rosuvastatin Calcium." Journal of Modern Pharmacology and Pathology 2 (June 6, 2024): 5. http://dx.doi.org/10.53964/jmpp.2024005.

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Objective: The goal of present study is to recognize acceptable excipients to increase performance and stability of oral solid formulations of rosuvastatin calcium by estimating compatibility study of rosuvastatin calcium and used excipients. Methods: Analytical instruments like fourier transform infrared spectroscopy Spectrum RX 1, [differential scanning calorimetry-Q20, TA], Bruker Advance Neo 500MHz NMR spectrometer, thin layer chromatography] were utilized. Excipients and rosuvastatin calcium were got from Loba chemie and Biocon, respectively. USP1-type dissolution apparatus, and Auto Dock

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4

Sutiswa, Shandra Isasi, Yeyet Cahyati, and Diky Mudhakir. "PENINGKATAN DISOLUSI ROSUVASTATIN CALSIUM DARI SEDIAAN TABLET DENGAN TEKNIK LIQUISOLID DAN PEMBENTUKAN KOMPLEKS INKLUSI." Jurnal Riset Kefarmasian Indonesia 1, no. 2 (2019): 93–102. http://dx.doi.org/10.33759/jrki.v1i2.21.

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Rosuvastatin calcium is a salt form of rosuvastatin with antilipidemia activity. Rosuvastatin Calcium classified in class two of Biopharmaceutics Clasification System (BCS) has low solubility in water (17.96 mg / L) and high permeability. Based on this, rosuvastatin calcium needs to be formulated appropriately in order to produce high bioavailability and maximum therapeutic effect. The bioavailability of BCS 2 drug is determined by the dissolution rate of the drug in gastrointestinal fluid so that a technique is needed in formulating the drug. This study aims to develop a formulation technique

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5

Rahul, Rajan R. S.1* Anitha Thomas2. "Simultaneous Estimation Of Rosuvastatin Calcium And Ezetimibe In Their Combined Tablet Dosage Form By Absorbance Ratio Method." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 180–86. https://doi.org/10.5281/zenodo.13646983.

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A simple, accurate, precise, and economical Q-absorbance ratio UV-spectrophotometric method was developed and validated for simultaneous estimating Rosuvastatin Calcium and Ezetimibe in combined tablet dosage form. The solvent used was a 1:1 t mixture of Isopropyl alcohol and distilled water. Two wavelengths 244nm (λmax of Rosuvastatin Calcium) and 240nm (Isoabsorptive point) were selected to estimate Rosuvastatin Calcium and Ezetimibe for the Q-Absorbance ratio method. The drug concentration was determined using the ratio of absorbance at the iso-absorptive point (λ1 = 240 nm) a

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6

Vishal, Sambhaji Sutar1* Nitin Anandrao Kamble2. "Phytochemical Screening And Gc-Ms Analysis Of Ocimum Sanctum, Amaranthus Viridis, And Cystone." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 258–70. https://doi.org/10.5281/zenodo.13694788.

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A simple, accurate, precise, and economical Q-absorbance ratio UV-spectrophotometric method was developed and validated for simultaneous estimating Rosuvastatin Calcium and Ezetimibe in combined tablet dosage form. The solvent used was a 1:1 t mixture of Isopropyl alcohol and distilled water. Two wavelengths 244nm (λmax of Rosuvastatin Calcium) and 240nm (Isoabsorptive point) were selected to estimate Rosuvastatin Calcium and Ezetimibe for the Q-Absorbance ratio method. The drug concentration was determined using the ratio of absorbance at the iso-absorptive point (λ1 = 240 nm) a

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7

Brijesh, Kumar Rajesh Kumar* Ashutosh Kumar Rikesh Patel. "SIMULTANEOUS RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF FENOFIBRATE AND ROSUVASTATIN CALCIUM IN BULK AND TABLET DOSAGE FORM." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4288–97. https://doi.org/10.5281/zenodo.1057885.

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An isocratic reversed-phase liquid chromatograpic assay method was developed for the quantitative determination of fenofibrate and rosuvastatin calcium in bulk and tablet dosage form. A Lichrosphere Select-B C8 (250x4.6mm & 5.0μm) column with a mobile phase containing Solution A (Milli-Q water has pH3.0 made by orthophosphoric acid): Methanol (20:80). The flow rate was 1.0 mL min−1: 1.5 ml/min and the detection of fenofibrate and rosuvastatin calcium was carried out on absorbance detector at 254nm.The retention times was 12 min (rosuvastatin- 3.40, fenofibrate-7.75). A linear response r2 &

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8

Pimpale, Awdhut, and Rajendra Kakde. "Development and Validation of Stability-Indicating Assay Method by RP-HPLC for Simultaneous Estimation of Rosuvastatin Calcium and Fenofibrate in Pharmaceutical Dosage Form." Journal of Drug Delivery and Therapeutics 10, no. 4 (2020): 79–86. http://dx.doi.org/10.22270/jddt.v10i4.4203.

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A Simple, precise, and accurate stability-indicating reversed-phase high-performance liquid chromatography method has been established for the simultaneous estimation of rosuvastatin calcium and fenofibrate in combined bulk and tablet formulation. The chromatographic separation was performed on reverse phase Princeton (C18) (250 mm x 4.6 mm, 5µ) column with mobile phase as a mixture of water (pH adjusted to 3.0 with orthophosphoric acid) and acetonitrile in the ratio (40:60) v/v at the flow rate 1.0 ml/min. Detection was carried out at wavelength 240 nm. The retention time under the optimized

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9

Jana, Kallol, and Beduin Mahanti. "An Improved Efficient Chromatographic Development and Validation for Quantitative Determination of Rosuvastatin Calcium and Cholecalciferol in Solid Pharmaceutical Tablets Dosage Forms." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 13, no. 04 (2022): 433–40. http://dx.doi.org/10.25258/ijpqa.13.4.15.

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The simple, reliable, sensitive and isocratic analytical chromatography was developed for the estimation, separation and validation of both the drugs rosuvastatin calcium and cholecalciferol in tablets dosage forms. Chromatographic elution was attained by C18 thermo, 250 x 4.6 mm column, with particle size 5 μm and 1.5 mL per minute flow rate using mobile phase as methanol : acetonitrile : triethanolamine (55:45:0.4%). Detection of both drugs were monitored at 265 nm. The retention time of rosuvastatin calcium and cholecalciferol were 1.336 and 6.031 minutes, respectively and overall chromatog

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10

Kansara, Devansh, Usmangani K. Chhalotiya, Hetaben M. Kachhiya, and Ishita Patel. "Development of TLC method for simultaneous estimation of novel combination of amlodipine besylate, rosuvastatin calcium, and fimasartan potassium in synthetic mixture." Journal of Chemical Metrology 14, no. 2 (2020): 142–52. http://dx.doi.org/10.25135/jcm.45.20.07.1744.

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An accurate, sensitive, robust and precise high performance thin layer liquid chromatography method was developed based on ICH Q2 (R1) guidelines for estimation of novel combination of Amlodipine besylate, Rosuvastatin calcium and Fimasartan potassium in bulk and its synthetic mixture. Pre-coated silica gel aluminum plate 60 F254 was selected as the stationary phase and n-hexane, n-butanol, methanol, and Glacial Acetic Acid (5.7:2:2.3:0.1, v/v/v/v) was selected as mobile phase. All three drugs showing appreciable absorbance at the common wavelength of 242 nm were selected for quantification of

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11

Kumar, Pramod, Amar Deep Ankalgi, Pooja Kaushal, and Mahendra Singh Ashawat. "Method Development and Validation for Multicomponent Analysis of Rosuvastatin Calcium and Losartan Potassium in Bulk Drug by RP-HPLC." Journal of Drug Delivery and Therapeutics 10, no. 5-s (2020): 76–84. http://dx.doi.org/10.22270/jddt.v10i5-s.4341.

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A simple, sensitive and specific liquid chromatographic method was developed for the simultaneous estimation of Rosuvastatin calcium and Losartan potassium in bulk form. Chromatographic conditions included the Column C-18 (Shim-pack) 250 x 4.6 mm, particle size 5 µm , mobile phase acetonitrile, methanol and water pH 3 (orthophosphoric acid) in the ratio 20:25:55 recorded at 233 nm. The retention time were found to be 3.55 and 4.64 min and average percentage recovery 99.42% and 99.63% for Rosuvastatin calcium and Losartan potassium respectively. The proposed method was found to comply with ICH

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12

Sheth, A., C. N. Patel, and N. J. Shah. "UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF ROSUVASTATIN CALCIUM AND HYDROCHLORTHIAZIDE IN THEIR COMBINED DOSAGE FORMS." INDIAN DRUGS 55, no. 05 (2018): 63–66. http://dx.doi.org/10.53879/id.55.05.10857.

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A simple, accurate, precise, reproducible and economical UV spectroscopic method for simultaneous estimation of Rosuvastatin calcium and Hydrochlorthiazide in marketed formulation has been developed. Method employs solving of simultaneous equations based on the measurement of absorbance at two wavelengths 243 nm and 270 nm which are the λmax values of rosuvastatin calcium and hydrochlorthiazide in methanol. The linearity of the method was investigated in range of 5-15 μg/mL for rosuvastatin calcium and 6.25-18.75 μg/mL for hydrochlorthiazide, respectively. The results of analyses have been val

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13

Pingale, Prashant L. "FORMULATION, DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE ROSUVASTATIN CALCIUM TABLET." Journal of Medical pharmaceutical and allied sciences 11, no. 6 (2021): 25–30. http://dx.doi.org/10.22270/jmpas.v10i6.1909.

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Rosuvastatin belongs to the statin medication class, which is used to treat excessive cholesterol and prevent heart disease. The Biopharmaceutical Classification System classifies it as class II. The goal of this project is to create 10 mg Rosuvastatin instant release pills using several types of materials. To boost the drug's bioavailability, superdisintegrants were used to speed up the disintegration and dissolution of Rosuvastatin calcium. Cited research work aims to formulate an immediate release tablet of Rosuvastatin for the treatment of hypercholesterolemia, hypolipoproteinemia, and ath

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14

Ashok, Praveen Kumar, Saurabh Pant, Sonu ., and Mandeep Limbu. "A Review on Method Development for the Analysis of Combine Product of Amlodipine Besilate and Rosuvastatin Calcium in Pharmaceutical Dosage form." Journal of Biomedical and Pharmaceutical Research 14, no. 1 (2025): 9–16. https://doi.org/10.32553/jbpr.v14i1.1224.

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Rosuvastatin belongs to the category of statins, used in combination with calcium channel blockers, analgesicsand other class of cardiovascular disease drugs in the treatment of high cholesterol and related conditions to prevent cardiovascular diseases. The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for quality control, pharmacodynamic and pharmacokinetic studies. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumentalmethods which were developed

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15

B. PADMAJA and S. SHOBHA RANI. "Development of rosuvastatin calcium nano-carrier patches by central composite design." GSC Biological and Pharmaceutical Sciences 27, no. 3 (2024): 123–33. http://dx.doi.org/10.30574/gscbps.2024.27.3.0528.

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Rosuvastatin (RS) is a statin medication used to lower cholesterol levels and reduce the risk of cardiovascular diseases. RS works by inhibiting an enzyme called HMG-CoA reductase, which helps decrease LDL cholesterol and increase HDL cholesterol. The typical dose range for rosuvastatin is 5-40 mg once daily, with the starting dose usually being 10 mg. However, the dosage may vary depending on the patient's cholesterol levels and individual response to the medication. Rosuvastatin has a half-life of approximately 19 hours and undergoes metabolism mainly in the liver. The aim of the study was t

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16

B., PADMAJA, and SHOBHA RANI S. "Development of rosuvastatin calcium nano-carrier patches by central composite design." GSC Biological and Pharmaceutical Sciences 27, no. 3 (2024): 123–33. https://doi.org/10.5281/zenodo.13383961.

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Rosuvastatin (RS) is a statin medication used to lower cholesterol levels and reduce the risk of cardiovascular diseases. RS works by inhibiting an enzyme called HMG-CoA reductase, which helps decrease LDL cholesterol and increase HDL cholesterol. The typical dose range for rosuvastatin is 5-40 mg once daily, with the starting dose usually being 10 mg. However, the dosage may vary depending on the patient's cholesterol levels and individual response to the medication. Rosuvastatin has a half-life of approximately 19 hours and undergoes metabolism mainly in the liver. The aim of the study was t

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17

Kishore, Chamarthi R. P., and G. V. Krishna Mohan. "Structural identification and estimation of Rosuvastatin calcium related impurities in Rosuvastatin calcium tablet dosage form." Analytical Chemistry Research 12 (June 2017): 17–27. http://dx.doi.org/10.1016/j.ancr.2016.11.002.

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18

Cal, Krzysztof, Barbara Mikolaszek, Tobias Hess, et al. "The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS Formulation of Rosuvastatin Calcium." Pharmaceuticals 16, no. 2 (2023): 242. http://dx.doi.org/10.3390/ph16020242.

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Sprinkle formulations represent an interesting concept of medicinal products aimed at the steadily growing population of patients suffering from swallowing difficulties (dysphagia). In the present work, immediate-release sprinkle MUPS (multiple-unit pellet system) containing rosuvastatin calcium as a model drug substance was successfully developed. The formulation was prepared by drug layering technique using novel calcium phosphate-based starting pellets (PharSQ® Spheres CM) of three different particle sizes. The study showed that the developed multiparticulates were characterized by uniform

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19

Padmanabh, Deshpande*and Amit Gunge. "SIMULTANEOUS ESTIMATION OF ROSUVASTATIN CALCIUM AND EZETIMIBE AS BULK DRUG AND IN TABLET DOSAGE FORM BY RP-HPLC METHOD." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 3197–202. https://doi.org/10.5281/zenodo.1239783.

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A simple, rapid, specific and sensitive reverse phase high performance liquid chromatography was developed and validated for simultaneous estimation of Rosuvastatin calcium and Ezetimibe in combined tablet formulation. The separation was achieved by Thermo C18 column (4.6mm x 250 mm) with a mobile phase consisting of Acetonitrile: Water (80: 20 v/v) at a flow rate of 1.0 mL min-1 . Detection wavelength was 241 nm. Retention times were found to be 1.758 min and 3.133 min for Rosuvastatin calcium and Ezetimibe, respectively. The developed method was validated interms of linearity, precision, acc

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20

Aggarwal, Rajesh K., and Refai Showkathali. "Rosuvastatin calcium in acute coronary syndromes." Expert Opinion on Pharmacotherapy 14, no. 9 (2013): 1215–27. http://dx.doi.org/10.1517/14656566.2013.789860.

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21

Pradhan, Braja, Naresh Vempala, Settipalli Venkateswara Rao, and Anireddy Shree. "An Asymmetric Synthesis of Rosuvastatin Calcium." Synthesis 48, no. 23 (2016): 4167–74. http://dx.doi.org/10.1055/s-0035-1562787.

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22

Tian, Lei, Li Xu, Jian Li, and Mei He. "Synthesis of deuterium-labeled rosuvastatin calcium." Journal of Radioanalytical and Nuclear Chemistry 324, no. 3 (2020): 941–47. http://dx.doi.org/10.1007/s10967-020-07165-x.

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23

Abdullah Ali, Hezha, and Hunar Kamal Omer. "Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques." Advances in Pharmacological and Pharmaceutical Sciences 2022 (November 28, 2022): 1–16. http://dx.doi.org/10.1155/2022/7161660.

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Purpose. The biopharmaceutics classification system places rosuvastatin calcium in class II has a low and fluctuating oral bioavailability. The research focus is to maximize rosuvastatin calcium solubility in water and dissolution rate by employing and combining various hydrotropic agents to make a solid dispersion using solvent evaporation techniques. Methodology. The experimental study was conducted at Duhok University, College of Pharmacy. Initially, assess rosuvastatin’s solubility in hydrotropic agents including urea, mannitol, citric acid, sodium benzoate, and sodium salicylate at concen

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24

Prakash, Gnana. "Formulation and Evaluation of Prolonged-Release Tablets Containing Solid Dispersions of Rosuvastatin Calcium." Future Journal of Pharmaceuticals and Health Sciences 1, no. 4 (2021): 180–85. http://dx.doi.org/10.26452/fjphs.v1i4.180.

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Pharmaceutical Industry is striving hard to improve the dissolution of drugs with limited water solubility. One of the approaches to improve the dissolution rate of poorly soluble drugs is solid dispersion. Hence in the present research, an attempt was made to improve the bioavailability of Rosuvastatin by formulating it as a solid dispersion. The release of Rosuvastatin calcium solid dispersion was prolonged using HPMC. Eudragit L-100 and PEG-6000 were used as carriers. Nine formulations of prolonged-release Rosuvastatin calcium (RS-SD 1 to RS-SD 9) were prepared and evaluated for pre and pos

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25

Anusha, Pashikanti Sai, and Dr M. Sunitha Reddy. "Formulation and Evaluation of Rosuvastatin Calcium Immediate Release Tablets Using Beta Cyclodextrin." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 10 (2022): 511–17. http://dx.doi.org/10.36348/sjmps.2022.v08i10.004.

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In order to treat Hyperlipidaemia, Rosuvastatin, a Dyslipidaemia drug, inhibits the HMG-CoA reductase enzyme. However, the calcium form of Rosuvastatin (RST) has low bioavailability, undesirable dissolving characteristics, and issues with absorption. Thus objective of the study is to increase the solubility and dissolution rate of Rosuvastatin calcium a poorly water-soluble 3-hydroxy 3-methyl glutaryl CoA (HMG-CoA) Reductase inhibitor through inclusion Complexation with β-cyclodextrin (β-CD). Therefore, the goal of the current study was to create a Rosuvastatin tablet formulation for oral diss

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Xiong, Fangjun, Haifeng Wang, Lingjie Yan, et al. "Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization." Organic & Biomolecular Chemistry 14, no. 4 (2016): 1363–69. http://dx.doi.org/10.1039/c5ob02245b.

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27

Singh, R., and T. Khan. "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION STUDIES FOR THE ESTIMATION OF ASPIRIN, CLOPIDOGREL BISULPHATE AND ROSUVASTATIN CALCIUM IN FIXED DOSE COMBINATION (CAPSULE) BY UV SPECTROSCOPY." INDIAN DRUGS 54, no. 06 (2017): 43–47. http://dx.doi.org/10.53879/id.54.06.10885.

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A simple, accurate and precise UV spectroscopy method has been developed for the simultaneous estimation of aspirin, rosuvastatin calcium and clopidogrel bisulphate in fixed dose combination (capsule). The third order derivative spectra were used and 290.36 nm, 243.84 nm and 256.16 nm were selected as detection wavelengths. A linear calibration curve was obtained in the concentration range of 20-100 μg/mL for aspirin; 6-20 μg/mL for rosuvastatin calcium and 10-100 μg/mL for clopidogrel bisulphate. The developed method was validated as per the ICH guidelines Q2(R1) for linearity, range, accurac

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28

Feng, Wenhao, Peixi Liu, Haiyue Yin, et al. "Heparin and rosuvastatin calcium-loaded poly(l-lactide-co-caprolactone) nanofiber-covered stent-grafts for aneurysm treatment." New Journal of Chemistry 41, no. 17 (2017): 9014–23. http://dx.doi.org/10.1039/c7nj01214d.

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29

Dr., T. AYYAPPAN, SARANYA G., R.VIGNESWARAN, and T. VETRICHELVAN Dr. "Studies on Formulation and in-Vitro Evaluation of Mucoadhesive Microbeads of Rosuvastatin Calcium by using Central Composite Design." International Journal of Innovative Science and Research Technology 8, no. 3 (2023): 438–48. https://doi.org/10.5281/zenodo.7758381.

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The Mucoadhesive drug delivery system was a new approach in pharmaceutical field and drug retention for a prolonged time has been achieved. Rosuvastatin calcium is a HMG-CoA Reductase inhibitors (statins) used in the treatment of percholesterolemia or hyperlipidemia. Mucoadhesive micro beads of Rosuvastatin calcium were successfully prepared by Ionotropic gelation technique. Central composite design was applied for the preparation and optimization of mucoadhesive microbeads using Statease-Design of Experiment Version–12 software. The results of preformulation studies showed that there wa

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30

Nahar, Jinnatun, Md Al-Amin, and Sumaya Mahmud Sharna. "Degradation Study of Different Brands of Rosuvastatin Calcium Tablet in Bangladesh Using UV Spectrophotometer." International Journal of Innovative Science and Research Technology 5, no. 7 (2020): 288–91. http://dx.doi.org/10.38124/ijisrt20jul097.

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Rosuvastatin calcium tablets are mainly five brands obtainable that is a synthetic compound which decreases the number of lipid portion which is placed as a hypercholesterolemia treatment. The major purpose of this study is to measure the stability of different brands of Rosuvastatin calcium on the stress condition. Degradation system is a procedure that includes the degradation of drug particles and drug ingredients at specific conditions. Those are generated into degradation products which can be studied to evaluate the quality and efficacy of the drug formulation. There are some guidelines

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31

Wang, Yanting, and Xiaogang Wang. "Clinical Effect of Nimodipine Combined with Rosuvastatin Calcium in the Treatment of Hypertensive Intracerebral Hemorrhage." Clinical Neuroscience Research 3, no. 1 (2025): 1–7. https://doi.org/10.26689/cnr.v3i1.9877.

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Objective: To explore the clinical effect of nimodipine combined with rosuvastatin calcium in the treatment of hypertensive intracerebral hemorrhage. Methods: Sixty patients with hypertensive intracerebral hemorrhage from January 2023 to December 2023 were randomly divided into a control group (n = 30) and an observation group (n = 30). The control group received conventional treatment, while the observation group was treated with nimodipine + rosuvastatin calcium tablets. The neurological function, edema volume, hematoma volume, adverse reactions, and treatment efficiency were compared betwee

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32

Belozerova, N. M., P. Bilski, M. Jarek, et al. "Exploring the molecular reorientations in amorphous rosuvastatin calcium." RSC Advances 10, no. 55 (2020): 33585–94. http://dx.doi.org/10.1039/d0ra06108e.

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Molecular reorientations in rosuvastatin calcium, a drug that is widely used to prevent cardiovascular disease, were explored thoroughly by means of solid state nuclear magnetic resonance (<sup>1</sup>H, <sup>13</sup>C NMR) combined with calculations of steric hindrances.

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R, Panner Selvam, Kulkarni P. K, and Naga Sravan Kumar Varma V. "Porous polystyrene spheres loaded self nano-emulsifying systems of rosuvastatin calcium." RSC Advances 5, no. 85 (2015): 69642–50. http://dx.doi.org/10.1039/c5ra12045d.

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34

Ciosek-Skibińska, Patrycja, Krzysztof Cal, Daniel Zakowiecki, and Joanna Lenik. "Potentiometric Electronic Tongue for the Evaluation of Multiple-Unit Pellet Sprinkle Formulations of Rosuvastatin Calcium." Materials 17, no. 20 (2024): 5016. http://dx.doi.org/10.3390/ma17205016.

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Sprinkle formulations represent an interesting genre of medicinal products. A frequent problem, however, is the need to mask the unpleasant taste of these drug substances. In the present work, we propose the use of a novel sensor array based on solid-state ion-selective electrodes to evaluate the taste-masking efficiency of rosuvastatin (ROS) sprinkle formulations. Eight Multiple Unit Pellet Systems (MUPSs) were analyzed at two different doses (API_50) and (API_10), as well as pure Active Pharmaceutical Ingredient (API) as a bitter standard. Calcium phosphate-based starter pellets were coated

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35

Surti, INaazneen, BZalak Patel, SKruti Patel, and SAnkit Shah. "Preparation and optimization of microemulsion of rosuvastatin calcium." Journal of Pharmacy and Bioallied Sciences 4, no. 5 (2012): 118. http://dx.doi.org/10.4103/0975-7406.94164.

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36

Raturi, Ankita, Ganesh Bhatt, and Preeti Kothiyal. "FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN CALCIUM." International Journal of Drug Regulatory Affairs 1, no. 3 (2018): 14–18. http://dx.doi.org/10.22270/ijdra.v1i3.115.

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Poor water solubility and slow dissolution rate are issues for majority of upcoming and existing biologically active compounds. The aim of present work was to increase the dissolution rate of Rosuvastatin Calcium, a poorly water soluble drug and hence improve its oral bioavailability by Nanosuspension technology. Nanosuspension is new carrier free colloidal drug delivery system with nano sized particles below 1000 nm, and considered as a great drug delivery technique to enhance the drug dissolution and solubility. In the present work Nanosuspension is made by nanoprecipitation technique in the

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37

Zhou, Yingtao, Chenhui Lin, Yuzhi Xing, Ligong Chen, and Xilong Yan. "Efficient Construction of the Nucleus of Rosuvastatin Calcium." Journal of Heterocyclic Chemistry 54, no. 3 (2016): 1898–903. http://dx.doi.org/10.1002/jhet.2785.

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38

Miller, Allison W., Christina D. Tulbert, and David W. Busija. "Rosuvastatin treatment reverses impaired coronary artery vasodilation in fructose-fed, insulin-resistant rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287, no. 1 (2004): R157—R160. http://dx.doi.org/10.1152/ajpregu.00647.2003.

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Insulin resistance (IR) impairs vascular responses in coronary arteries, but mechanisms of dysfunction and approaches to treatment remain unclear. We examined the ability of a new 3-hydroxy-methylglutaryl coenzyme A reductase inhibitor, rosuvastatin, to reverse reduced dilator responses in rats made IR by feeding a fructose-rich diet (FF). Sprague-Dawley rats were randomized to control (normal rat diet) or FF. After 1 wk, rats received rosuvastatin (2 mg/kg) or placebo (saline) subcutaneously for 5 wk. Biochemical measurements and in vitro functional studies of small coronary arteries were per

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Najafi, Mohammad, Nadia Esfandiari, Bizhan Honarvar, and Zahra Arab Aboosadi. "Production of Rosuvastatin Calcium Nanoparticles Using Gas Antisolvent Technique." Periodica Polytechnica Chemical Engineering 65, no. 4 (2021): 442–53. http://dx.doi.org/10.3311/ppch.16629.

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The activity of pharmaceutical substances crucially depends on the bioavailability of the substances. The bioavailability of drugs in body and their rate of dissolution in the biological fluids are increased if the particle size is decreased. In the present paper, the Gas Anti-Solvent (GAS) method was used to lower the size of rosuvastatin particles. The effects of temperature (313–338 K), pressure (105–180 bar) and initial solute concentration (20–60 mg/ml) were evaluated by Response Surface Methodology (RSM). The optimum initial solute concentration, temperature and pressure were found to be

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Gupta, Alka, P. Mishra, and K. Shah. "Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations." E-Journal of Chemistry 6, no. 1 (2009): 89–92. http://dx.doi.org/10.1155/2009/956712.

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A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of rosuvastatin calcium in bulk and in pharmaceutical formulations. Rosuvastatin exhibits absorption maxima at 244 nm with apparent molar absorptivity of 7.2345 ×104L/mol.cm in methanol. Beer’s law was found to be obeyed in the concentration range of 2-18 µg/mL. The method is accurate, precise and economical. This method is extended to pharmaceutical preparations. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analy

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Mistry, Rujuta P., Chainesh Shah, and Rakesh Jat. "RP-HPLC method development and validation for simultaneous estimation of telmisartan, rosuvastatin calcium, and amlodipine besylate in combination." Folia Medica 64, no. 1 (2022): 103–9. http://dx.doi.org/10.3897/folmed.64.e64339.

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Introduction: Dyslipidemia-hypertension proves to be a major risk factor for cardiovascular diseases. In order to achieve better adherence and cost-effectiveness than free equivalent combination therapies, a fixed-dose combination therapy with telmisartan (TEL), rosuvastatin calcium (ROS) and amlodipine besylate (AML) is required in this type of patients.&nbsp; Aim: A simple, selective and reproducible reverse phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for estimation of telmisartan, rosuvastatin calcium, and amlodipine besylate in synthet

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Liu, Zhongjin, Ruiqing Li, Chunmei Zhang, Jia Liu, and Haiyan Zhang. "Rosuvastatin Calcium Affects Alzheimer's Disease Through Regulating Defensive Transduction Pathways of Oxidative and Chemical Stress Signaling Pathway." Journal of Biomaterials and Tissue Engineering 9, no. 10 (2019): 1414–19. http://dx.doi.org/10.1166/jbt.2019.2150.

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Alzheimer's disease (AD) treatment is not effective. Statins are lipid-lowering drugs. However, the role and mechanism of statins for treating AD remains unclear. SD rats were separated into sham operation group; AD group and rosuvastatin calcium group followed by analysis of cognitive function and neuronal morphology. ELISA was to measure the level of TNF-α and IL-1; SOD activity and ROS levels were measured,. Real-time quantitative PCR was to analyze Bcl-2 and Bax level. The expression of Nuclear Erythroid 2-Related Factor 2/Antioxidant Responsive Element (NRF2/ARE) signaling pathway was ana

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Beg, Sarwar, Kaisar Raza, Rajendra Kumar, Renu Chadha, O. P. Katare, and Bhupinder Singh. "Improved intestinal lymphatic drug targeting via phospholipid complex-loaded nanolipospheres of rosuvastatin calcium." RSC Advances 6, no. 10 (2016): 8173–87. http://dx.doi.org/10.1039/c5ra24278a.

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The present work describes the systematic development and characterization of nanolipospheres (NLPs) loaded with phospholipid complex of rosuvastatin for enhanced oral drug absorption trough lymphatic pathways.

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González, Rocío, Mª Ángeles Peña, Norma Sofía Torres, and Guillermo Torrado. "Design, development, and characterization of amorphous rosuvastatin calcium tablets." PLOS ONE 17, no. 3 (2022): e0265263. http://dx.doi.org/10.1371/journal.pone.0265263.

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This work proposes a methodology for the design, development, optimisation, and evaluation of amorphous rosuvastatin calcium tablets (BCS class II drug). The main goal was to ensure rapid disintegration and high dissolution rate of the active ingredient, thus enhancing its bioavailability. The design started from a careful selection of excipients, which due to their characteristics and proportions within the formulation allowed the use of their properties such as fluidity or granulometric distribution. The formulation was characterised using scanning electron microscopy (SEM), differential sca

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Hirsch, Mark, John C. O'donnell, and Peter Jones. "Rosuvastatin is Cost-Effective in Treating Patients to Low-Density Lipoprotein-Cholesterol Goals Compared with Atorvastatin, Pravastatin and Simvastatin: Analysis of the Stellar Trial." European Journal of Cardiovascular Prevention & Rehabilitation 12, no. 1 (2005): 18–28. http://dx.doi.org/10.1177/204748730501200104.

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Background Rosuvastatin calcium (CRESTOR®) has demonstrated superior efficacy in reducing low-density lipoprotein cholesterol (LDL-C). However, healthcare providers and authorities require information on its cost-effectiveness in the treatment of dyslipidaemia. Design A retrospective pharmacoeconomic analysis was performed using data from the Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin (STELLAR) trial. The cost-effectiveness of rosuvastatin 10-40 mg was compared with atorvastatin 10-80 mg, pravastatin 10-40 mg and both branded and generic simvastatin 10-80

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Lakshmi, S. Satya, Y. Srinivasa Rao, D. Asha, P. V. Kamala Kumari, and P. N. Mallikarjun. "Formulation and evaluation of rosuvastatin-calcium drug transdermal patch." Research Journal of Pharmacy and Technology 13, no. 10 (2020): 4784. http://dx.doi.org/10.5958/0974-360x.2020.00841.0.

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Vempala, Naresh, Balaji Matta, S. Venkateswara Rao, Shambabu Joseph Maddirala, and A. Jaya Shree. "An efficient, cyanide free total synthesis of rosuvastatin calcium." Tetrahedron 111 (April 2022): 132717. http://dx.doi.org/10.1016/j.tet.2022.132717.

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Kapure, V. J., V. V. Pande, and P. K. Deshmukh. "Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique." Journal of Pharmaceutics 2013 (February 27, 2013): 1–9. http://dx.doi.org/10.1155/2013/315902.

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In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression paramete

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Atul, A. Shirkhedkar Pankaj D. Mahajan Amod S. Patil. "REVIEW ON HYPHENATED ANALYTICAL TECHNIQUES IMPLEMENTED FOR ANALYSIS OF ROSUVASTATIN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9183–95. https://doi.org/10.5281/zenodo.2688835.

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<em>Rosuvastatin calcium [RSV] specifically inhibit the enzyme 3-hydroxy-3-methylglutaryl-Co-enzyme A [HMG-CoA] reductase. It belongs to family of cholesterol lowering medications which are denoted as statins and useful in treatment of dyslipidemia where it helps in reducing the chances of arthrosclerosis development by decreasing the level of bad cholesterol and hence eliminating the possibilities of heart diseases. RSV was developed by Astra-Zeneca and it was granted approval in 2003 by US-FDA. This article presents a literature review on hyphenated analytical techniques implemented for the

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G. Garg, Aayush, Yash Raj Singh, Darshil B. Shah, Dilip G. Maheshwari, and Jignesh S. Shah. "Quality by Design Based Development and Quantification of Telmisartan and Rosuvastatin Calcium Using RP-HPLC." Oriental Journal Of Chemistry 39, no. 3 (2023): 763–71. http://dx.doi.org/10.13005/ojc/390329.

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RP-HPLC technique to estimate the Telmisartan and Rosuvastatin Calcium, employing an experimental design method using response surface methodology, was developed and validated. Experimental design was used to evaluate a multivariate optimisation of experimental conditions using flow rate, buffer pH, and % of acetonitrile in the mobile phase as three independent variables. The peak symmetry and retention time of the last eluting peak were optimized employing Derringer’s desirability function in which 1 ml/min flow rate, KH2PO4 buffer with pH 3.5 (altered with 1% orthophosphoric acid), and 65% v

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