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Dissertations / Theses on the topic 'Rot damage'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Brunoni, Michele. "Ocorrência e danos de podridões do colmo e grãos ardidos no estado de Santa Catarina." Universidade do Estado de Santa Catarina, 2015. http://tede.udesc.br/handle/handle/1217.

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Made available in DSpace on 2016-12-08T16:44:50Z (GMT). No. of bitstreams: 1 PGPV15MA169.pdf: 682086 bytes, checksum: e66cb9ecfd276d4b0dca8a7c5e02653d (MD5) Previous issue date: 2015-02-27<br>The state of Santa Catarina is a major producer and consumer of corn kernels. Much of this cereal is used by agribusinesses in the production of animal protein. The stalk rot (PC) and ear can harm the quality and quantity of grain produced. The objective of this study was to quantify damage caused by PC in different altitudes in the state of Santa Catarina, identify the pathogens involved, assess the qu

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2

Menegati, Giovani da Costa. "Podridões do colmo, rendimento de grãos de híbridos de milho nos campos de cima da serra/rs e variabilidade na determinação de grãos ardidos." Universidade do Estado de Santa Catarina, 2013. http://tede.udesc.br/handle/handle/1190.

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Made available in DSpace on 2016-12-08T16:44:47Z (GMT). No. of bitstreams: 1 PGPV13MA146.pdf: 1025870 bytes, checksum: 3db0ad6dd00a768dbc759ef22dc655a4 (MD5) Previous issue date: 2013-12-03<br>To gain a better understanding of the importance of corn stalk rot in grain yield and quality a field and laboratory experiments were conducted in order to accomplish the following objectives a) evaluate the stalk rot (SR) incidence and its effect on grain yield in eight corn hybrids cultivated under no-till system with soybean rotation and oats succession, in three locations of Campos de Cima da Serra

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3

Al-Chaderchi, Balsam, and Mohammed Abuabed. "Kartläggning av vattenskador- inverkan av byggsystem och aktörernas attityd." Thesis, Linnéuniversitetet, Institutionen för byggteknik (BY), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-89024.

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Studien går ut på att undersöka vattenskador som har blivit allt vanligare i svenska byggnader. Vattenskador utsätter människan för hälsorisker på grund av en hög risk för mikrobiell tillväxt. Syftet med studien är att undersöka vattenskador, var uppstår vattenskador och varför, vilka kostnader står försäkringsbolagen för och vilka kostnader står fastighetsägare eller utförare för. Inom studien undersöktes också hur olika aktörer ser på vattenskador och risker med olika typer av stommaterial. Resultatet av studien visar att försäkringsbolagen bedömer alla stommaterial lika när det gäller ersät

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4

Chatham, J. C. "Biochemical aspects of myocardial damage." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376900.

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5

Fazendeiro, Marta Sofia Pereira Pingarilho. "DNA damage induced by acrylamide: roe of genetic polymorphisms in DNA damage levels." Doctoral thesis, Faculdade de Ciências Médicas. UNL, 2013. http://hdl.handle.net/10362/10000.

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RESUMO:Em 1994 a acrilamida (AA) foi classificada pela IARC como um provável cancerígeno para o homem. Para além da utilização de AA em numerosas aplicações industriais, a AA está também presente numa grande variedade de alimentos ricos em amido e processados a temperaturas elevadas. Esta exposição através da ingestão de produtos alimentares despoletou elevadas preocupações ao nível do risco para a saúde pública e poderá implicar um risco adicional para o aparecimento de cancro. A glicidamida (GA), o metabolito epóxido formado a partir da oxidação da AA provavelmente através do citocromo P450

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6

Kadziauskas, Jurgis Vidmantas. "Ląstelių membranų funkcionavimo tyrimai." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090507_135344-67125.

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Hibridiniai baltymai, koduojami sulietų lamB ir lacZ genų susiriša su išvirkščiomis E.coli ląstelių plazminės membranos pūslelėmis. Sąveika su plazmine membrane priklauso nuo geno secA produkto buvimo. Hibridinių baltymų susirišimas su membrana priklauso nuo išorinės membranos baltymo LamB polipeptidinės grandinės ilgio. Aktyviosios deguonies formos, susidariusios fotosensibilizuojant eukariotų ląsteles lipofiliniu sensibilizatoriumi sukelia membranų pažaidas, padidina lipidų peoksidacijos lygį ir laktato dehidrogenazės išėjimą iš ląstelių. Vidinių ląstelių pažaidos sumažina ląstelių oksidored

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7

Lahne, Manuela. "Damage-induced signalling mechanisms in the neonatal rat cochlea." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444911/.

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Sound overstimulation and exposure to ototoxic drugs damage cochlear hair cells (HCs) and cause their death. The surrounding support cells maintain an epithelial barrier and the appropriate physiological environment for surviving HCs during pathological conditions. Coordination of this homeostatic process requires cellular signalling. However, the signalling events that are activated during damage in the mammalian cochlea, are poorly understood. Neonatal rat cochlear explants were subjected to mechanical damage or exposed to neomycin - an ototoxin. Mechanical damage triggered the immediate pro

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8

Shangula, Suha. "Effect of paraoxonase (PON1) on lactones and ROS induced DNA damage." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/effect-of-paraoxonase-pon1-on-lactones-and-ros-induced-dna-damage(928ac761-7039-4f6f-9135-40a6f71b9465).html.

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Paraoxonase 1 (PON1) is an enzyme synthesised in the liver that is associated with High Density Lipoprotein (HDL) and increasingly with a number of human diseases, including cardiovascular disease and cancer. PON1 is (i) a lactonase, hydrolysing aliphatic and aromatic lactones, (ii) a phosphotriesterase, acting on certain organophosphates and (iii) a peroxidase that combats lipid oxidation. The aim of this study was to investigate the extent to which PON1 might impact on the levels of lactone-induced and oxidative DNA damage. Initially, the plasmid DNA (pDNA) nicking assay was used to show tha

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9

Harding, Richard James. "Biochemical pathways underlying cellular damage in the perfused rat heart." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241343.

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10

Daniels, Stephanie. "Biochemical mechanisms of cellular damage in the isolated rat heart." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293744.

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11

Arvin, Babak. "Neuroprotection against excitotoxic cell damage in rat striatum and hippocampus." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278696.

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12

Barker, Anthony David Purslove. "The damage potential of the root-lesion nematode Pratylenchus bolivianus in the UK." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312235.

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13

Harbort, Christopher. "Regulation of innate immunity by DNA damage signaling." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2017. http://dx.doi.org/10.18452/17791.

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Neutrophile sind Zellen des Immunsystems von Säugetieren. Ihre zerstörerische Kraft spielt eine essentielle Rolle bei der Bekämpfung von Mikroorganismen, birgt aber auch das Potential erheblicher Kollateralschäden. Um chronische Entzündungen zu vermeiden, müssen diese Zellen streng reguliert werden. Die Neutrophilen selber nehmen an dieser Regulierung durch das Freisetzen von pro- und antiinflammatorischen Signalen Teil, unter anderem produzieren sie Zytokine oder initiieren rechtzeitig die Apoptose. Ein Eckpfeiler der Regulierung dieser Funktionen ist der oxidative Burst, bei dem Neutrophile

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14

Manley, Jennifer J. "An assessment of DNA damage in rat sperm following cyclophosphamide treatment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0026/MQ50826.pdf.

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15

Ahmed, Suwayda. "Evaluation of dentine damage after rotary NiTi preparation." University of the Western Cape, 2016. http://hdl.handle.net/11394/5602.

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Magister Scientiae Dentium - MSc(Dent)<br>NiTi rotary instruments have shape memory and are highly flexible and super-elastic. These properties of the metal alloy allows for ease of root canal preparation to ultimately result in a root canal preparation that has a continuous taper, while canal shape and curvature is maintained. It must be noted that the NiTi rotary instrumentation may have an effect on root canal dentine, which may manifest as dentine damage. Different NiTi rotary systems on the market vary with regards to their design features and kinematics, which may influence dentine damag

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16

Tang, Wai-ho Jack. "Polyol pathway contributes to iron-induced oxidative damage in ischemia-reperfused rat hearts." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39558022.

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17

黑明燕 and Mingyan Hei. "Neuroprotection of tanshinone IIA to hypoxic-ischemic brain damage in neonatal SD rat." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29797809.

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18

鄧偉豪 and Wai-ho Jack Tang. "Polyol pathway contributes to iron-induced oxidative damage in ischemia-reperfused rat hearts." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39558022.

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19

Kashaija, Imelda Night. "Factors influencing nematode population densities and root damage on banana cultivars in Uganda." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309517.

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20

Jones, Caroline Elizabeth Mary. "The development, evaluation and use of freshly isolated renal proximal tubule systems from the Fischer rat." Thesis, Aston University, 1990. http://publications.aston.ac.uk/12575/.

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The investigation of renal pathophysiology and toxicology has traditionally been advanced by the development of increasingly defined and refined in vitro preparations. This study has sought to develop and evaluate various methods of producing pure samples of renal proximal tubules (PTs) from the Fischer rat. The introduction summarised the most common in vitro preparations together with the parameters used to monitor viability - particularly with regard to toxic events. The most prevalent isolation methods have involved the use of collagenase to produce dissociation of the cortex. However, the

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21

Siracusa, Julien. "Étude des microARNs circulants comme biomarqueurs de lésions musculaires." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS330.

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Les lésions musculaires sont des événements fréquents. Le diagnostic repose sur la mesure de biomarqueurs sanguins. Les outils actuels présentent des limites qui justifient la recherche de nouveaux candidats biomarqueurs. Récemment, des petits ARNs non codants, les microARNs (miARNs), ont été identifiés. Détectables dans le plasma, certains sont spécifiques d’un tissu et ont été proposés comme de potentiels biomarqueurs de lésions tissulaires. Toutefois, leur intérêt dans le diagnostic des lésions musculaires chez l’individu sain n’est pas connu. Le but de ce travail était d’identifier et de c

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22

Smith, Heather K. "Skeletal muscle damage and repair in the adult rat hindlimb following downhill treadmill exercise." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq28304.pdf.

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23

Seo, Hyoungseock. "Damage tolerance and durability of GLARE laminates." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1779690411&sid=13&Fmt=2&clientId=48051&RQT=309&VName=PQD.

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24

Billing, S. E. "An evaluation of different methods of measuring lipid peroxidation and their application to the assessment of liver cell damage induced by certain hepatoxic agents." Thesis, Brunel University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383745.

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25

Kim, Brian Y. "Dependence of Duration and Frequency on Location Specific Vascular Damage in the Rat Tail Model." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397734478.

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26

Barata, André Bernardo Antunes dos Santos Neves. "Microbial ecology of sour rotten grapes and their influence on chemical and sensorial wine quality." Doctoral thesis, ISA/UTL, 2011. http://hdl.handle.net/10400.5/3875.

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Doutoramento em Engenharia Alimentar - Instituto Superior de Agronomia<br>The grape berry microbiota is deeply influenced by the sanitary status of grapes. In sound grapes the most frequent yeast species were basidiomycetes, Aureobasidium pullulans, Candida zemplinina and Hanseniaspora uvarum. Sour rotten grapes were mostly colonised by C. zemplinina, H. uvarum, Issatchenkia spp. and Zygoascus hellenicus. The presence of minoritary populations of Zygosaccharomyces bailii was only found in damaged grapes. The acetic acid bacteria Gluconobacter spp. and Gluconoacetobacter spp. were isolated from

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27

Abdul, Salam Safnas Farwin. "Biochemistry of Reactive Oxygen Species in Selective Cancer Cell Toxicity and Protection of Normal Cells." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511880706270521.

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28

Abreu, Fabiana Marchi de. "Quantificação de danos e controle pós-colheita de podridão parda (Monilinia fructicola) e podridão mole (Rhizopus spp.) em pêssegos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/11/11135/tde-22012007-150735/.

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O objetivo desse trabalho foi quantificar e caracterizar danos pós-colheita em pêssegos comercializados na Companhia de Entrepostos e Armazéns Gerais de São Paulo - CEAGESP e testar produtos sanificantes no controle de podridão parda (Monilinia fructicola) e podridão mole (Rhizopus spp.). Para tanto, foram realizadas vinte avaliações semanais, entre as safras de 2003 e 2004, amostrando-se 1% do total de caixas de pêssegos em cinco permissionários que comercializam esta fruta. As amostragens foram estratificadas por variedade, calibre e produtor. Em todos os frutos de cada amostra foram quantif

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29

Shaik, Raziya. "Photochemical Generation of the C5' -Uridinyl and Pseudouridinylradical for the Study of Oxidative Damage in RNA." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1384518841.

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30

Peluffo, Zavala Hugo. "Neuroprotective gene therapy strategies applied to the acutely damaged immature rat brain." Doctoral thesis, Universitat Autònoma de Barcelona, 2006. http://hdl.handle.net/10803/3781.

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Un daño agudo al sistema nervioso central (SNC) desencadena una serie de eventos complejos e interrelacionados, entre los cuales encontramos tres especialmente importantes: excitotoxicidad, estrés oxidativo e inflamación. En particular, el cerebro inmaduro muestra varias características que lo hacen especial en cuanto a sus reacciones frente a lesioned agudas. En este contexto, la presente Tesis contribuye al conocimiento básico de los procesos de estrés oxidativo e inflamación que ocurren luego de una lesión excitotoxica mediada por inyección de NMDA en el cerebro inmaduro. Asimismo, desarrol

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31

Tonolli, Paulo Newton. "O papel do fator de transcrição mitocondrial A (TFAM) na proteção do DNA mitocondrial contra lesões oxidadas." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-29042014-144505/.

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O fator de transcrição mitocondrial A (TFAM) pertence ao grupo das proteínas de alta mobilidade, apresentando um importante papel para a replicação, transcrição e estrutura/organização do DNA mitocondrial (DNAmt). O DNAmt está organizado em um complexo nucleoprotéico, chamado de nucleóide, do qual TFAM é o principal componente protéico, empacotando o DNAmt de forma análoga às histonas no DNA nuclear. Em analogia ao DNA nuclear, foi sugerido que esse empacotamento pode proteger o DNAmt do ataque de espécies oxidantes, enquanto que, por outro lado, poderia também impedir o acesso das enzimas de

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32

Hobbs, Leanne Marie. "Dietary fish oil administration prevents the development of renal damage in the salt-loaded hypertensive rat /." Title page and abstract only, 1994. http://web4.library.adelaide.edu.au/theses/09SB/09sbh682.pdf.

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33

Smit, Elisa. "Effects of hyperoxia and therapeutic hypothermia in an immature rat model of neonatal hypoxicischaemic brain damage." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685357.

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The introduction of therapeutic hypothermia and the guidance on the cautious use of oxygen during resuscitation of newborn infants are two of the greatest advances in neonatal care over the last decade. The combination of the two has not been researched in great detail, but is of great clinical relevance. This thesis discusses and investigates the use of 100% oxygen following resuscitation in an immature rat model of hypoxiaischaemia in combination with therapeutic hypothermia. Pups on postnatal day 7 are traditionally used in this model. However, pups on postnatal day 10 (P10) are more approp

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34

Fumagalli, M. "Characterization of the mechanisms controlling the DNA damage response in human cellular senescence." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/60446.

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All organisms respond to breaks in the DNA by promptly launching the DNA-damage response (DDR). This involves the recruitment of DNA repair proteins to sites of DNA damage and the activation of “checkpoint” activities that slow down or arrest cell-cycle progression, thus delaying key cell cycle transitions until the damage has been removed. In multicellular organisms, the inability to repair DNA damage and/or prolonged checkpoint activation can lead to programmed cell death or cause the cell to enter a permanent cell cycle arrest known as cellular senescence. The goal of my PhD period was t

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35

Tanushi, Xhaferr. "Impairing the repair of the oxidative DNA damage 8-oxoG in nuclear and mitochondrial genomes, which consequences for the cell?" Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL070.

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OGG1 est une ADN glycosylase de la voie de réparation par excision de base (BER) qui excise spécifiquement la guanine oxydée 8oxoG. La voie BER est bien connue pour son rôle dans la maintenance du génome nucléaire mais elle est également la principale voie de réparation de l'ADN mitochondrial. La déficience de l'activité d'OGG1 entraîne une mutagenèse importante lors de la réplication de l'ADN nucléaire, ce qui n'a pas été détecté au niveau de l'ADNmt. Malgré cela, la déficience d'OGG1 induit une augmentation des ROS mitochondriaux, une perte du potentiel de la membrane mitochondriale et une a

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36

Prunell, dos Santos Giselle F. "Pathophysiology of subarachnoid hemorrhage in the rat /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-610-3/.

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37

Taura, Akiko. "Recovery of hair cell function after damage induced by gentamicin in organ culture of rat vestibular maculae." Kyoto University, 2007. http://hdl.handle.net/2433/135651.

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38

Su, Dan. "Microcrack damage and its effect on stress wave propagation." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 114 p, 2009. http://proquest.umi.com/pqdweb?did=1654487641&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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39

GUNN, SHAYLA. "Induction of Stress Response, Cell Wall Damage, and Cell Death in Determination of Silver Nanoparticle Toxicity Threshold of the Heavy-metal Accumulating Fern Azolla caroliniana." OpenSIUC, 2018. https://opensiuc.lib.siu.edu/theses/2333.

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The field of nanoecotoxicology has been pioneered in recent years as concern grows in response to the potential environmental hazards of engineered nanoparticle release. Silver nanoparticle (AgNP) release through induction into commercial products as an antimicrobiont is of particular interest. Plausible routes of AgNPs to reach aquatic systems and their biological impacts have been investigated, but none have addressed the potential remediation of these waters using the heavy metal accumulating fern Azolla caroliniana. This study employed biological staining techniques and fluorescence micros

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40

Azarbayjani, Faranak. "Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5065-2/.

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41

Goenka, Shilpi. "Influence of higher frequency components and duration of mechanical vibration on artery and bone in a rat-tail model." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378195712.

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42

Gao, Yong. "Noninvasive monitoringn of CCl4 induced acute and chronic liver damage in rat by single quantum and triple quantum filtered 23Na magnetic resonance imaging." Connect to resource online, 2008. http://hdl.handle.net/1805/2045.

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Thesis (M.S.)--Indiana University, 2008.<br>Title from screen (viewed on January 26, 2010). Department of Cellular & Integrative Physiology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Navin Bansal, Andriy M. Babsky, Stephen A. Kempson, David P. Basile. Includes vitae. Includes bibliographical references (leaves 33-36).

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43

Wang, Jie. "Fibroblast growth factor-2 protects neonatal rat cardiac myocytes from doxorubicin-induced damage via protein kinase C- dependent effects on efflux drug transporters." Cardiovascular Research, 2013. http://hdl.handle.net/1993/18318.

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Introduction: Therapeutic agents like doxorubicin, an anthracycline antibiotic drug, are widely used in cancer chemotherapy. The use of doxorubicin is limited however by an increased risk of cardiac damage as a side effect, and an increased cancer cell drug resistance mediated by efflux drug transporters. Strategies are needed to protect the heart and still allow the benefits of drug treatment. “Basic” fibroblast growth factor-2 (FGF-2) is a multi-functional protein. It is angiogenic and cardioprotective against ischemia-reperfusion injury. FGF-2 can also regulate cancer cell drug resistance

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44

Graf, Michael Georg Eduard. "Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillarstructural damage without cell death in adult rat cardiomyocytes /." [S.l.] : [s.n.], 2009. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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45

Porter, Shane Noel. "Assessment of intestinal damage and a novel therapeutic intervention in a rat model of colitis using breath testing /." Adelaide, 1996. http://web4.library.adelaide.edu.au/theses/09S.B/09s.bp848.pdf.

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Thesis (B. Sc.(Hons.))--University of Adelaide, Dept. of Physiology, 1996.<br>Spine title: "Assessment of DSS-induced colitis using breath testing." Includes bibliographical references (leaves 23-30).

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46

Lee, Ming-Yi. "Interactions between corticotrophin releasing hormone and heat shock protein 72 in glutamate-induced neuronal damage in rat hippocampus." Thesis, University of Warwick, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397514.

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47

Amin, Alla Mohammed Hussain. "Cold ischaemia and reperfusion injury in liver : the potential for damage to cellular DNA in the rat model." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248455.

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48

Turner, John James Dennis. "Interactions of forebrain cholinergic projection system damage with Benzodiazepine receptor ligand effects on cognitive performance in the rat." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399072.

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49

Singhapol, Chatchawan. "Mitochondrial localisation of hTERT protects against nuclear DNA damage and mitochondrial ROS production after endogenous and exogenous stress." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2216.

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Under oxidative stress condition, telomerase catalytic subunit can shuttle from the nucleus and localises within mitochondria. hTERT can improve mitochondrial functions and contribute to a decreased oxidative stress suggesting an entirely new function of telomerase in protecting mitochondria and cells under stress. However, there are still many questions about the mechanism and what factors influence the protective function of telomerase. In this study we investigated the kinetic exclusion of hTERT, the catalytic subunit of telomerase, in various cell lines under different oxidative stress con

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Bianchetti, Elena. "Cell death neuroprotection and repair mechanisms in a model of rat spinal cord injury in vitro." Doctoral thesis, SISSA, 2013. http://hdl.handle.net/20.500.11767/4099.

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Abstract:

Nowadays, new spinal cord injury (SCI) cases are frequently due to non traumatic causes, especially vascular disorders. A prerequisite to developing mechanism-based neuroprotective strategies for acute SCI is a full understanding of the early pathophysiological changes to prevent later disability and paralysis. The immediate damage spreads from the initial site through excitotoxicity and metabolic dysfunction (ischemia, free radicals and neuroinflammation) to surrounding tissue (secondary damage). Using an in vitro neonatal rat spinal cord model, an experimental protocol (pathological medium,

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