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Journal articles on the topic 'Rota Rod Test'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Panigrahy, Sarita. "Evaluation of centrally acting skeletal muscle relaxant activity of aqueous extract of Withania somnifera (ashwagandha) roots in albino mice." International Journal of Basic & Clinical Pharmacology 8, no. 1 (2018): 157. http://dx.doi.org/10.18203/2319-2003.ijbcp20185176.

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Background: Skeletal muscle relaxants are used to treat both muscle spasm and spasticity, acting both as antispasmodic and antispasticity agents. In past studies some polyherbal formulations containing ashwagandha have shown skeletal muscle relaxant activity and fat extract of ashwagandha showed skeletal muscle relaxant activity in experimental animal models. This study is designed to evaluate the skeletal muscle relaxant activity of aqueous extract of Withania somnifera (ashwagandha) roots in albino mice, as the literature regarding them is limited.Methods: Standard drug (diazepam) and differ

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Dunn, David A., and Carl A. Pinkert. "Nuclear Expression of a Mitochondrial DNA Gene: Mitochondrial Targeting of Allotopically Expressed Mutant ATP6 in Transgenic Mice." Journal of Biomedicine and Biotechnology 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/541245.

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Nuclear encoding of mitochondrial DNA transgenes followed by mitochondrial targeting of the expressed proteins (allotopic expression; AE) represents a potentially powerful strategy for creating animal models of mtDNA disease. Mice were created that allotopically express either a mutant (A6M) or wildtype (A6W)mt-Atp6transgene. Compared to non-transgenic controls, A6M mice displayed neuromuscular and motor deficiencies (wire hang, pole, and balance beam analyses;P<0.05), no locomotor differences (gait analysis;P<0.05) and enhanced endurance in Rota-Rod evaluations (P<0.05). A6W mice exh

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Luzzani, F., P. Cipolla, M. L. Pélaprat, et al. "Brain penetration and neurological effects of gadobenate dimeglumine in the rat." Acta Radiologica 38, no. 2 (1997): 268–72. http://dx.doi.org/10.1080/02841859709172061.

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Purpose: the study aimed at measuring the amount of the gadobenate ion that crosses an experimentally disrupted blood-brain barrier (BBB) in rats following i.v. administration of gadobenate dimeglumine (GD). the intention was also to compare this amount with the minimally effective intrathecal dose that alters the cerebral function. Methods: Sprague Dawley rats with an osmotically disrupted BBB received 0.3 mmol/kg of (153Gd)GD, i.v. Radioactivity was measured in plasma and brain parenchyma. the effect on the cerebral function was evaluated by means of a standard motor coordination test (Rota-

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Assunção, Amanda Fonseca Costa, Nícolas Davidson Sérvulo Rodrigues, Andreia Viana da Costa Sampaio, et al. "Alpha-terpineol: evaluation and pharmacological screening as an antidepressant agent." Research, Society and Development 10, no. 11 (2021): e191101119571. http://dx.doi.org/10.33448/rsd-v10i11.19571.

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Objective: To evaluate the possible antidepressant effects of alpha-terpineol in rodents. Material and Methods: Depression levels were analyzed by comparing the total immobility time presented by the animals of the experimental groups in the test session, using the Forced Swimming Test and the Tail Suspension Test. The parameters of locomotion (central, peripheral and total) and motor coordination were evaluated in the Open Field Test and in the Rota Rod Test, respectively. In the second stage, the involvement of the noradrenergic system in the antidepressant action of alpha-terpineol in Force

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Shahed-Al-Mahmud, Md. "Evaluation of sedative and hypnotic activities of ethanolic extract of leaves of Cleome rutidosperma DC. (Capparidaceae) in mice." Journal of Pharmaceutics and Therapeutics 4, no. 1 (2018): 215–23. http://dx.doi.org/10.18314/jpt.v4i1.1356.

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Cleome rutidosperma DC. (Capparidaceae) traditionally used medicine for insomnia and depression management. The aim of the recent study conducted to investigate the sedative and hypnotic activities of ethanolic extract from the leaves of C. rutidosperma (EECR) in Swiss Albino mice. Neuropharmacological test on mice employed to this study sedative (open field, hole cross, hole- board and rota-rod tests) and hypnotic (thiopental sodium-induce sleeping test) activities of EECR in mice model. The acute toxicity study and phytochemical analysis of EECR also carried out. EECR exhibits significant (p

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Santos, Priscila L., Adriano A. S. Araújo, Jullyana S. S. Quintans та ін. "Preparation, Characterization, and Pharmacological Activity ofCymbopogon winterianusJowitt ex Bor (Poaceae) Leaf Essential Oil ofβ-Cyclodextrin Inclusion Complexes". Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/502454.

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This study aimed to evaluate the orofacial antinociceptive effect of theCymbopogon winterianusessential oil (LEO) complexed inβ-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS). The LEO was extracted, chromatographed, and complexed inβ-cyclodextrin. The complex was characterized by differential scanning calorimetry (DSC) and thermogravimetry derivative (TG/DTG). Male Swiss mice (2-3 months) were treated with LEO-CD (50–200 mg/kg, p.o.), vehicle (distilled water, p.o.), or standard drug (i.p.) and subjected to the orofacial nociception formalin-,

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Nofitasari, Lutfi, Jason Merari Peranginangin, and Sri Rejeki Handayani. "Aktivitas Antiparkinson Ekstrak Gambir (Uncaria Gambir Roxb.) Pada Tikus Putih (Rattus Norvegicus) Galur Sprague Dawley yang Diinduksi Haloperidol." Jurnal Farmasi Indonesia 14, no. 2 (2019): 169–81. http://dx.doi.org/10.31001/jfi.v14i2.373.

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Parkinson merupakan penyakit yang terjadi akibat adanya kerusakan sel saraf dopaminergik pada bagian otak yang mengakibatkan terjadinya penurunan produksi dopamin. Gambir adalah ekstrak kering yang dibuat dari daun tumbuhan Uncaria gambir Roxb. Gambir mengandung flavonoid berupa katekin tidak kurang dari 90%, alkaloid dan terpenoid. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak gambir yang dapat mengurangi gejala parkinson pada tikus putih jantan galur Sprague dawley yang diinduksi haloperidol.Hewan uji sebanyak 35 ekor tikus dibagi menjadi 7 kelompok. Kelompok I (kontrol sehat)

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Sneha, Nawale 1. *. P. Pranusha1 K. Padma Priya1 M. Ganga Raju 2. "EVALUATION OF ANTI CATALEPTIC ACTIVITY FOR METHANOLIC EXTRACT OF AERVA LANATA WHOLE PLANT." Journal of Pharma Research 8, no. 7 (2019): 520–25. https://doi.org/10.5281/zenodo.3365637.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he present study was done to evaluate the anti-cataleptic activity for methanolic extract of </em><em>Aerva lanata</em><em> whole plant (MEAL) in haloperidol induced catalepsy (HIC) and clonidine induced catalepsy (CIC) in mice. Catalepsy was induced by administering haloperidol (1.0 mg/kg bd.wt, i.p.) and clonidine (0.5 mg/kg, bd.wt, </em><em>s.c.</em><em>) daily for 21 days. The anti-cataleptic effect of </em><em>Aerva lanata</em><em> was evaluated by standard bar test, locomotor activity, rota rod test, and cook’s pole

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Hou, Lin, Zhixiang Chen, Shengmin Zhao, and Yaoyue Wei. "Age-Dependent Effects C57BL/6 Genetic Mutations under Mice Models of Parkinson's Disease on Motor Ability." International Journal of Sciences Volume 4, no. 2015-10 (2015): 9–11. https://doi.org/10.5281/zenodo.3349031.

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As literature reported, C57BL/6 A53T mutant human alpha-synuclein under the mice is one successful model related to Parkinson's disease(PD). In previous studies, over-accumulation of alpha-synuclein which lead to lewy body, were revealed to cause impairment on motor ability in Parkinson's disease mouse model. Nevertheless, in the open filed test and the rota-rod test, hyperactivity and motor ability improvements at 12 months old was found in our study.Read Complete Article at ijSciences: V4201510855 AND DOI: http://dx.doi.org/10.18483/ijSci.855

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Yang, Yang, Shao-Ju Jin, Hong-Ling Wang, et al. "Effects of aloperine on acute and inflammatory pain models in mice." Scandinavian Journal of Pain 8, no. 1 (2015): 28–34. http://dx.doi.org/10.1016/j.sjpain.2015.04.001.

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AbstractBackground and objectivesAloperine (ALO) is an alkaloid compound and presents in several medicinal plants. This study was undertaken to investigate the anti-nociceptive and anti-inflammatory activities of ALO on various chemical- and thermal-induced hypersensitivity models in mice.MethodsThe anti-nociceptive effect of ALO was evaluated using acetic acid-induced writhing test, hot plate test, tail flick test, formalin test, ear swelling test, locomotor activity test, rota-rod test and carrageenan-induced paw edema test in mice. Inflammatory cytokines including interleukin-10 (IL-10), tu

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Bagewadi, Harish G., Rajeshwari ., Patil Banderao V., and Syed Hasan Zahid. "Rotarod test and Catalepsy bar test: behavioral testing and neuromodulation of Aloe vera in MPTP induced Parkinson’s disease animal model." International Journal of Basic & Clinical Pharmacology 7, no. 3 (2018): 494. http://dx.doi.org/10.18203/2319-2003.ijbcp20180663.

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Background: Aloe vera (Family Liliaceae) has been used for the treatment of diabetes, skin disorders and as anti-inflammatory agent. Objectives: behavioral testing of antiparkinsonian effect of Aloe vera in MPTP induced animal model.Methods: Rotarod test and Catalepsy bar test were used for behavioral assessment. Assessment of oxidative stress was done in the striatal region of the brain by reduced glutathione (GSH) measurement.Results: A. vera (200 and 400mg/kg, p.o.) was found to significantly increase the retention time in rota rod test and significantly decrease the latency period in catal

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Yoon, Eun-Jung, Hye Rim Seong, Jangbeen Kyung, et al. "Stamina-Enhancing Effects of Human Adipose-Derived Stem Cells." Cell Transplantation 30 (January 1, 2021): 096368972110354. http://dx.doi.org/10.1177/09636897211035409.

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Stamina-enhancing effects of human adipose derived stem cells (hADSCs) were investigated in young Sprague-Dawley rats. Ten-day-old male rats were transplanted intravenously (IV) or intracerebroventricularly (ICV) with hADSCs (1 × 106 cells/rat), and physical activity was measured by locomotor activity and rota-rod performance at post-natal day (PND) 14, 20, 30, and 40, as well as a forced swimming test at PND 41. hADSCs injection increased the moving time in locomotor activity, the latency in rota-rod performance, and the maximum swimming time. For the improvement of physical activity, ICV tra

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Allahyar, Razia, Atif Akbar, and Furhan Iqbal. "Effect of creatine monohydrate supplementation on learning, memory and neuromuscular coordination in female albino mice." Acta Neuropsychiatrica 29, no. 1 (2016): 27–34. http://dx.doi.org/10.1017/neu.2016.28.

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BackgroundResearch findings made over the last few years have highlighted the important role of creatine (Cr) in health and disease. However, limited information is available regarding the effect of Cr supplementation on cognation. Present study was designed to determine the effect of variable doses of Cr (1% and 3%) on selected parameters of female albino mice behaviour.MethodsFollowing weaning, on 20th postnatal day, female albino mice were divided into three groups on the basis of dietary supplementation. Control group were was fed with normal rodent diet, whereas treated groups received di

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Jubie, Selvaraj, Rajamanickam Gayathri, and Rajagopal Kalirajan. "Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives." Scientific World Journal 2012 (2012): 1–8. http://dx.doi.org/10.1100/2012/718023.

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Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid was reacted with three different ketones and formaldehyde to give the corresponding Mannich bases in satisfactory yield. Their structures were confirmed by using1H NMR, IR, and mass analysis. In pharmacological evaluation, the synthesized compounds showed its curative effect against ethidium-bromide-induced demyelination in rats. For the purpose, different screening methods such as open field exploratory behavior test, rota rod test, grip strength test, beam walk test, and photo actometer te

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Milovanović, Mirjana, Miloš Milosavljević, Marjanović S. Đorđe, et al. "The Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats." Acta Veterinaria 66, no. 4 (2016): 478–88. http://dx.doi.org/10.1515/acve-2016-0041.

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AbstractCarvacrol is a monoterpenic phenol and an active ingredient of the plant essential oils of the family Lamiaceae. We have investigated the analgesic effect of carvacrol, the possible dependence of the effect in relation to animal sex, and the impact of carvacrol on motor coordination in rats. Hyperalgesia was induced by formalin (1.5%), which was administered SC in the upper lip of rat. Hyperalgesia and effects of carvacrol and indomethacin were measured by using the orofacial formalin test. The influence on motor coordination in animals treated with carvacrol was investigated by using

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Rabelo Lopes, Livian, Fellipe Alexandre Alves Moraes, João Paulo Costa Rodrigues та ін. "A repositioning approach: nitazoxanide inhibits inflammation and nociceptive response in mice models via a reduction of paw oedema, cellular migration and early TNF-α production". Revista Colombiana de Ciencias Químico-Farmacéuticas 53, № 2 (2024): 385–413. https://doi.org/10.15446/rcciquifa.v53n2.114448.

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Introduction: Various studies have evaluated the in vitro anti-inflammatory effect of nitazoxanide (NTZ), suggesting new therapeutic functions for this drug. Aims: To evaluate the in vivo anti-inflammatory and antinociceptive activities of NTZ in acute mice models. Methods: Mice models of paw oedema, abdominal writhing, formalin and the rota-rod test were used. Results: Oral treatment with NTZ induced inhibition of paw oedema (60.00% and 66.67% at doses of 10 and 30 mg/kg, respectively) in the first hour after inflammatory stimulus, carrageenan (Cg). There was also a significant inhibition of

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de, Campos Mesquita Débora Mothé, Silva de Souza Giliane da, Marinete Pinheiro Carrera, Arthur Giraldi-Guimarães, and Olga Lima Tavares Machado. "Blocking IgE with L-glutamic acid analogs as an alternative approach to allergy treatment." European Journal of Biological Research 13, no. 1 (2023): 31–40. https://doi.org/10.5281/zenodo.7686100.

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IgE-mediated allergic diseases have increased in the last decades. The most prevalent allergens from these seeds are Ric c1 and Ric c3, isoforms of 2S albumin. These allergenic proteins cross-react with allergens from peanut, shrimp, fish, corn, gramineous, house dust, and tobacco. The usual allergy treatment employs antihistaminic, immunotherapies and, omalizumab (Xolair)-based anti-IgE therapy. However, antihistaminics relieve symptoms, and the high cost of omalizumab limits its use for continuous treatment. We propose an alternative immunotherapeutic approach, denoted “IgE-blockage&rd

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Moniruzzaman, Md, Md Atikur Rahman, and Afia Ferdous. "Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract ofScoparia dulcisLinn." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/873954.

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Scoparia dulcisLinn. (SD) is a perennial herb that has been well studied for its antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective effects. However, scientific information on SD regarding the neuropharmacological effect is limited. This study evaluated the sedative and hypnotic effect of the ethanolic extract of whole plants ofScoparia dulcis(EESD). For this purpose, the whole plants ofS. dulciswere extracted with ethanol following maceration process and tested for the presence of phytochemical constituents. The sedative and hypnotic activity were then investigated using hole

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Sinoria, A., R. Irchhaiya, S. Gupta, and V. Lahariya. "ANTICONVULSANT AND MUSCLE RELAXANT ACTIVITY OF CASSIA FISTULA LINN. SEED EXTRACT IN EXPERIMENTAL MICE." INDIAN DRUGS 51, no. 05 (2014): 33–38. http://dx.doi.org/10.53879/id.51.05.p0033.

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Phytochemical and pharmacological investigation was carried out on the seeds of Cassia fistula Linn plant for anticonvulsant and muscle relaxant activity in mice. The hydro-alcoholic extract of seeds of Cassia fistula (100, 200 and 400 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and muscle relaxant activity at the dose level using rota rod and traction test in mice. Preliminary phytochemical analysis revealed presence of saponin, carbohydrate, glycosides, flavonoids, tannin and phenolic compounds. Cassia fistula hydro-alcoholic extract (CFHE)

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Oliveira-Macêdo, L. A. R., A. G. M. Pacheco, S. R. G. Lima-Saraiva, et al. "Fractions of Selaginella convoluta (Arn.) Spring (Selaginellaceae) attenuate the nociceptive behavior events in mice." Brazilian Journal of Biology 80, no. 1 (2020): 57–65. http://dx.doi.org/10.1590/1519-6984.189761.

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Abstract Selaginella convoluta (Arn.) Spring is a species popularly known as “jericó”, and used in folk medicine as analgesic and anti-inflammatory. This study aimed to investigate in mice the antinociceptive and anti-inflammatory activities of the hexane (Sc-Hex) and chloroform (Sc-CHCl3) fractions (100, 200 and 400 mg/kg) obtained by partition of crude ethanol extract from S. convoluta. The preliminary phytochemical analysis of the fractions was performed. Antinociceptive activity was evaluated by writhing, formalin and hot-plate tests. Anti-inflammatory activity was evaluated using carragee

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Suloon, Jacklin, Azam Shah Mohamad, Lee Ming-Tatt, et al. "HEXANIC FRACTION OF TURMERIC POWDER ATTENUATES MURINE MODEL OF INDUCEDNOCICEPTION AND ITS POSSIBLE MECHANISMS OF ACTION." African Journal of Traditional, Complementary and Alternative Medicines 12, no. 6 (2015): 90–99. http://dx.doi.org/10.21010/ajtcam.v12i6.9.

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Background: The current study was conducted to further examine the antinociceptive activity of hexane fraction of turmeric powder (HFTP) and to elucidate the possible mechanisms of action underlying its antinociceptive activity in various experimental models of chemical- and thermal-induced nociception. Materials and Methods: Acetic acid-induced abdominal constriction, hot-plate, formalin-, capsaicin- and glutamate-induced paw licking tests in mice were employed in the antinociceptive investigation of HFTP. In all experiments, HFTP was administered intraperitoneally at

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Patil, Vinod R., and Chandrashekar D. Upasani. "A Novel Approach for Evaluation of Hesperidin in Vincristrine-Induced Neuropathy in Rats." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 20–27. http://dx.doi.org/10.25258/ijpqa.15.1.03.

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The present study set out to determine how hesperidin altered the neuropathic pain that vincristine-induced on rats. Rats were given vincristine to cause painful neuropathy. To measure the mechanical dynamic allodynia, cold allodynia, degree of mechanical hyperalgesia, heat hyperalgesia in addition to muscle relaxants rota rod, respectively, several pain-sensitive tests, including the von frey hair test pinprick, hot plate, and rota rod, were carried out on various weeks (00, 04 and 08 week ). As indicators of inflammation and oxidative stress, the IL-1β, IL-10, and tumor necrosis factor-α, ti

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Patil, Vinod R., and Chandrashekhar D. Upasani. "The Assessment of Ferulic Acid in Rats with Vincristine-Induced Neuropathy." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 44–51. http://dx.doi.org/10.25258/ijpqa.15.1.07.

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The main goal of the current investigation was to find out how ferulic acid (FA) affected the neuropathic pain that vincristine caused in rats. Rats were given vincristine to cause painful neuropathy. To measure the mechanical dynamic allodynia, cold allodynia, degree of mechanical hyperalgesia, heat hyperalgesia, and muscle relaxant rota rod, respectively. Several pain-sensitive tests, including the von frey hair test, pinprick, hot plate, and rota rod, were carried out on various weeks (0, 4 and 8 weeks) as indicators of inflammation and oxidative stress the IL-1β, IL-10, tumour necrosis fac

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Du, Xiaoxue, Yuzhen Xu, Shijia Chen, and Marong Fang. "Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and NLRP3 Pathway." Neural Plasticity 2020 (August 28, 2020): 1–11. http://dx.doi.org/10.1155/2020/8825954.

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Ischemia cerebral stroke is one of the common neurological diseases with severe inflammatory response and neuron death. The inhibition of colony-stimulating factor 1 receptor (CSF1R) which especially expressed in microglia/macrophage exerted neuroprotection in stroke. However, the underlying neuroinflammatory regulation effects of CSF1R in ischemia stroke are not clear. In this study, cerebral ischemia stroke mice model was established. The C57/B6J mice were administered with Ki20227, a CSF1R inhibitor, by gavage for 7 consecutive days (0.002 mg/kg/day) before modeling. The Rota-Rod test and n

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Reyes M., Marta Inés, and Amarilis Saravia G. "Contribución al estudio farmacológico de las hojas de Daucus Carota I. (Zanahoria), Anathum Graveolens L. (eneldo) y Achillea Millefollium L. (milenrama) de uso popular en Guatemala como sedantes e hipnóticos." Revista Científica 11, no. 1 (1996): 40–43. https://doi.org/10.54495/rev.cientifica.v11i1.372.

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La presente investigación com prende un estudio de las propiedades Farmacológicas (hipnóticas y sedan tes) atribuidas a Daucus carota (zanahoria), Aneth um graveolens (eneldo), y a chilles millefollium (milenrama) de uso popular en Guatemala. Para comprobar dichos efectos terapéuticos, se prepararon infusiones de las plantas anteriormente mencio nadas y se administraron a ratones albinos de un peso aproximado de 20g. Los test que fueron empleados para este estudio fueron los de Boissier y utilizando la Placa aguje reada, Rota Rod y Chimenea y el de Potencialización del Sueño de Winter. Los res

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Kamdi, Amit S., Devesh D. Gosavi, Suvarna M. Kalambe, and Pankaj N. Bohra. "The motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by rota rod test." Indian Journal of Pharmacy and Pharmacology 7, no. 2 (2020): 73–76. http://dx.doi.org/10.18231/j.ijpp.2020.015.

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Galdino, Pablinny Moreira, Marcus Vinícius Mariano Nascimento, Fábio Borges de Sousa, Reginaldo Nassar Ferreira, José Realino de Paula, and Elson Alves Costa. "Central activities of hydroalcoholic extract from Lafoensia pacari A. St.-Hil. stem bark." Brazilian Journal of Pharmaceutical Sciences 46, no. 3 (2010): 455–62. http://dx.doi.org/10.1590/s1984-82502010000300008.

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Lafoensia pacari A. St.-Hil. can be found from Amapá to Rio Grande do Sul states, and also in Paraguay and Bolivia. It is popularly known as pacari or mangava-brava and is used to promote weight loss, as an anti-thermal or tonic, to treat gastritis, ulcers, scarring, itching, discouragement, and cancer. In the open field tests, the hydroalcoholic extract from L. pacari stem bark (HEP) decreased the number of rearings, number of invaded squares, and increased immobility time compared to control animals. In the pentobarbital-induced sleep time test, HEP decreased latency time to sleep and increa

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Cherevatenko, R. F., O. V. Antsiferov, S. Y. Skachilova, et al. "THE SEARCH FOR NEUROPROTECTIVE COMPOUNDS AMONG NEW ETHYLTHIADIAZOLE DERIVATIVES." Pharmacy & Pharmacology 8, no. 4 (2021): 263–72. http://dx.doi.org/10.19163/2307-9266-2019-8-4-263-272.

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The aim of the study is to search compounds with neuroprotective properties among new ethylthiadiazole derivatives in simulated traumatic brain injury.Materials and methods. The experiment was carried out on 78 white male rats 270±20 g line “Wistar” 5–6 months of age and 120 outbred sexually mature mice weighing 20±2 grams. The article describes the search for compounds with neuroprotective properties among new ethylthiadiazole derivatives under the codes LKHT 4–15, LKHT 10–18, LKHT 11–18, and LKHT 12–18 in experimental traumatic brain injury in rats. Acute toxicity of the compounds was studie

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Han, Li, Chen Cong, Feng Yanbo, et al. "Comparative Study of the Components and Anti-Fatigue Effect of Schisandra chinensis Polysaccharides from China and Russia." Natural Product Communications 17, no. 2 (2022): 1934578X2210769. http://dx.doi.org/10.1177/1934578x221076979.

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Schisandra chinensis Bail. polysaccharides from China (CSP) and Russia (RSP) were separated by DEAE-52 cellulose column chromatography. The content of neutral polysaccharide was determined by the phenol concentrated sulfuric acid method, the content of acid polysaccharide by the hydroxybiphenyl method, and the monosaccharide composition and molecular weight arrangement of CSP and RSP by 1-phenyl-3-methyl-5-pyrazolone (PMP) pre-column derivatization HPLC. The effects of CSP and RSP on the exercise endurance of mice were compared by the forelimb grip strength test, rota-rod test and weight-beari

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Cheng, Yao, Shaik Althaf Hussain, Turki Mayudh Alrubie, and Xiaomin Zhang. "Neuroprotective Role of Transchalcone in Parkinson‘s Disease through AMP-activated Protein Kinase-mediated Signaling Pathway." Journal of Physiological Investigation 67, no. 6 (2024): 312–20. https://doi.org/10.4103/ejpi.ejpi-d-24-00083.

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Abstract Parkinson’s disease (PD) is a gradually worsening neurodegenerative condition marked by the deterioration of dopaminergic neurons, motor dysfunction, and mitochondrial dysfunction. Trans-chalcone, a natural flavonoid, has shown promise in various disease models because of its antioxidant and anti-inflammatory features. This study investigates the neuroprotective effects of transchalcone in a rat model of PD, focusing on its impact on the activation levels of AMP-activated protein kinase (AMPK) signaling pathway, sirtuin1 (SIRT1) and peroxisome proliferator-activated receptor gamma coa

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Milovanovic, Mirjana, Đorđe S. Marjanović, Saša M. Trailovic, and Danilo Stojanović. "Antinociceptive Effect of P-Cymene and Cinnamaldehyde: Their Relationship with the L-Arginine-Nitric Oxide Pathway in Rats." Acta Veterinaria 75, no. 2 (2025): 193–211. https://doi.org/10.2478/acve-2025-0016.

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Abstract Based on the previously known therapeutic properties of the active principles from essential plant oils, we investigated the antinociceptive effects of p-cymene (PC) and cinnamaldehyde (CNA) on carrageenan (CG)-induced inflammatory hyperalgesia in female Wistar rats, as well as their relationship with the L-arginine-nitric oxide pathway. Hyperalgesia was induced by intraplantar administration of CG (500 µg) into the rat hind paw, lasting 6 hours. The electronic von Frey apparatus measured the paw withdrawal threshold induced by pressure. Motor coordination in PC-treated animals was as

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Shridhar, Bhawna, and Sushil Kumar. "Advance In-Vivo Activities of Polyherbal Formulations (Foeniculum Vulgare, Emblica Officinalis and Ocimum Sanctum) with Different Pharmacological Studies." Journal of Advanced Zoology 44, no. 4 (2023): 329–38. http://dx.doi.org/10.17762/jaz.v44i4.1653.

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Herbal products with potential therapeutic and nutritional values are gaining importance among people around the world. Herbal products are typically regarded as safe for use on humans. The preparation and marketing of extracts from various herbal items or purified bioactive components takes many different forms. Products with more than two herbal extracts are called polyherbal products. They are frequently regarded as prophylactically or therapeutically useful due to their complimentary and/or potentiating functions as a result of the advantages of one another. The phytochemical screening was

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Toshkezi, Gentian, Michele Kyle, Sharon L. Longo, Lawrence S. Chin, and Li-Ru Zhao. "Brain repair by hematopoietic growth factors in the subacute phase of traumatic brain injury." Journal of Neurosurgery 129, no. 5 (2018): 1286–94. http://dx.doi.org/10.3171/2017.7.jns17878.

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OBJECTIVETraumatic brain injury (TBI) is a major cause of long-term disability and death in young adults. The lack of pharmaceutical therapy for post–acute TBI recovery remains a crucial medical challenge. Stem cell factor (SCF) and granulocyte colony–stimulating factor (G-CSF), which are 2 key hematopoietic growth factors, have shown neuroprotective and neurorestorative effects in experimental stroke. The objective of this study was to determine the therapeutic efficacy of combined treatment (SCF + G-CSF) in subacute TBI.METHODSYoung-adult male C57BL mice were subject to TBI in the cortex of

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Sulaiman, Mohd Roslan, Azyyati Mohd Padzil, Khozirah Shaari, et al. "Antinociceptive Activity ofMelicope ptelefoliaEthanolic Extract in Experimental Animals." Journal of Biomedicine and Biotechnology 2010 (2010): 1–6. http://dx.doi.org/10.1155/2010/937642.

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Melicope ptelefoliais a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of theMelicope ptelefoliaethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin-induced paw licking tests. Oral administration of MPEE produced significant dose-dependent antinociceptive effects when tested in mice and rats using acetic acid-induced abdominal constriction test and on th

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Herrero de la Parte, Borja, Javier Roa-Esparza, Iñigo Cearra, et al. "The Prevention of Ischemia-Reperfusion Injury in Elderly Rats after Lower Limb Tourniquet Use." Antioxidants 11, no. 10 (2022): 1936. http://dx.doi.org/10.3390/antiox11101936.

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Background: Lower limb ischemia-reperfusion injury (IRI-LL) is a common major complication of orthopedic surgery, especially in elderly patients. It has previously been demonstrated that folinic acid (FA) reduced IRI-LL damage in 3–4-month-old rats. This current work analyses the effect of FA in the prevention of IRI-LL in elderly animals. Methods: Forty-two 18-month-old male WAG/RijHsd rats were subjected to 3 h of ischemia. Eighteen animals received FA (2.5 mg/kg, ip) 20 min before the end of the ischemia period, while the other half received the same volume of saline solution. The animals w

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Machado, Keylla da Conceição, Márcia Fernanda Correia Jardim Paz, José Victor de Oliveira Santos та ін. "Anxiety Therapeutic Interventions of β-Caryophyllene: A Laboratory-Based Study". Natural Product Communications 15, № 10 (2020): 1934578X2096222. http://dx.doi.org/10.1177/1934578x20962229.

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The bicyclic sesquiterpene β-caryophyllene (BCP) has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, and analgesic effects. This study evaluates anxiolytic, toxicity, and antioxidant effects of BCP using in vitro and in vivo test models. The anxiolytic effects were tested in Swiss albino mice ( Mus musculus) by applying the elevated plus-maze, rota-rod, light and dark, and hiding sphere models, while the toxicity was evaluated by brine shrimp ( Artemia salina) lethality bioassay. Additionally, the antioxidant capacity was tested by using 2,2-diphenyl-1-pi

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Stalin, Chandrasekeran, V. Gunasekaran, and G. Jayabalan. "Evaluation of Neuroprotective Effect of Ficus benghalensis against Alloxan Induced Diabetic Neuropathy in Rats." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 4 (August 2016): 52–60. http://dx.doi.org/10.18052/www.scipress.com/ijppe.4.52.

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Neuropathic pain in diabetics is characterized by both hyperalgesia and allodynia. This is attributed to both uncontrolled glycemia and the further complications which it leads to. The objective of the study was to evaluate the neuroprotective effect of methanolic leaf extract of Ficus benghalensis against alloxan induced diabetic neuropathy in rats.Material and methods:Experimental diabetes was induced in wistar albino rats by single intraperitoneal injection of Alloxan monohydrate (150 mg/kg). The methanolic extract of leaves of Ficus benghalensis at a dose of 200 and 400 mg/kg body weight w

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Paudel, Sabita, Bijay Aryal, and Sunita Ranabhat. "Amoxicillin Induced Behavioral Neurotoxicity and Histopathological Changes in Organs of Albino Rats." Journal of College of Medical Sciences-Nepal 16, no. 1 (2020): 12–16. http://dx.doi.org/10.3126/jcmsn.v16i1.25282.

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Background: There are various adverse drug reactions of penicillin. Neurotoxicity is attracting the attention of researchers all over the world. It also affects other organs like liver, kidney, heart and testes Methods: The study was conducted at pharmacy and pharmacology department of Gandaki Medical College (GMC) from January till April, 2018. Albino rats were divided six each in test and control group. Tests were administered amoxicillin 90mg/kg/d and control with distilled water for 10 days. After 10 days, rats were tested for neurotoxicity with rota-rod (RR) and modified forced swim

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Kiroğlu, Olcay E., Kübra E. Demirkol, Fatih Berktaş, et al. "Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences." Clinical & Investigative Medicine 39, no. 6 (2016): 14. http://dx.doi.org/10.25011/cim.v39i6.27494.

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Purpose: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects. Methods: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks. Dipyrone was administered intrap

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Huerta Ojeda, Álvaro, Javiera Rodríguez Rojas, Jorge Cancino-López, et al. "Effects of Maca (Lepidium meyenii Walp.) on Physical Performance in Animals and Humans: A Systematic Review and Meta-Analysis." Nutrients 17, no. 1 (2024): 107. https://doi.org/10.3390/nu17010107.

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Background: Lepidium meyenii Walp. (LmW), known as maca, has been shown to increase physical performance. However, the effect size (ES) of LmW on the different manifestations of physical performance has not yet been described. Objectives: To examine and qualitatively describe the studies published up to 2024 that employed LmW supplementation to increase physical performance in animal and human experimentation. In addition, the ES associated with the different interventions was calculated. Methods: The research followed PRISMA® guidelines for systematic reviews and meta-analyses, using Web of S

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da Silva Oliveira, George L., José C. Correia L. da Silva, Ana P. dos Santos C. L da Silva, Chistiane M. Feitosa та Fernanda R. de Castro Almeida. "Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems". Current Molecular Pharmacology 14, № 1 (2020): 36–51. http://dx.doi.org/10.2174/1874467213666200510004622.

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Background: Central nervous system disorders such as anxiety, depression and epilepsy are characterized by sharing several molecular mechanisms in common and the involvement of the L-arginine/NO pathway in neurobehavioral studies with β-caryophyllene is still little discussed. Objectives: One of the objectives of the present study was to demonstrate the anxiolytic behavioral effect of β-caryophyllene (β-CBP) in female Swiss mice, as well as to investigate the molecular mechanisms underlying the results obtained. Methods: This study evaluated the neurobehavioral effects of β-CBP using the open

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Naidu, Sushma V., and Vibha Rani. "A study to evaluate the skeletal muscle relaxant property of Pregabalin and Gabapentin in albino rats." International Journal of Basic & Clinical Pharmacology 8, no. 6 (2019): 1381. http://dx.doi.org/10.18203/2319-2003.ijbcp20192206.

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Background: Skeletal muscle relaxants are the drugs which reduce unwanted spasm without interfering with consciousness and voluntary movements. The centrally acting muscle relaxants like Diazepam, is known to be GABA mimetics and other antiepileptics like Gabapentin and Pregabalin also act through the release of GABA. This study is done to investigate skeletal muscle relaxant property of these drugs in comparison to Diazepam.Methods: T Models used in the experiment are Grip Strength Test, Rota Rod Method, Beam Walk Test, Photoactometer Test. Animals were divided into 6 groups of 6 rats each: G

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Forouzanfar, Fatemeh, Mohammad M. Vahedi, Azita Aghaei, and Hassan Rakhshandeh. "Hydroalcoholic Extract of Cuscuta Epithymum Enhances Pentobarbitalinduced Sleep: Possible Involvement of GABAergic System." Current Drug Discovery Technologies 17, no. 3 (2020): 332–37. http://dx.doi.org/10.2174/1570163815666181105091801.

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Background: Insomnia is the most common sleep disorder. The present study was undertaken to evaluate the sedative-hypnotic potential of hydroalcoholic extract (HAE) of Cuscuta epithymum and its fractions. Methods: HAE and its fractions including: water fraction (WF), ethyl acetate fraction (EAF) and n-hexan fraction (NHF) were i.p administered to male mice and 30 min later pentobarbital (30 mg/kg, i.p.) was injected to induce sleep. Then the latent period and continuous sleeping time were recorded. Besides, 30 mins after administration of HAE motor coordination (rota-rod test) were assessed. A

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Ardhianta, Irsyad Rizky, Jasson Merari Peranginangin, and Sri Rejeki Handayani. "Aktivitas Antiparkinson Ekstrak Rosella (Hibiscus Sabbdariffa L.) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Sprague Dawley Yang Diinduksi Haloperidol." Jurnal Farmasi Indonesia 14, no. 2 (2019): 160–68. http://dx.doi.org/10.31001/jfi.v14i2.371.

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Penyakit parkinson merupakan penyakit yang disebabkan karena penurunan kadar dopamin pada pars compacta substantia nigra. Dopamin erat kaitannya dengan antioksidan, karena antioksidan dapat mengurangi radikal bebas yang merusak sel-sel penghasil dopamin. Rosella adalah salah satu tanaman yang mempunyai kandungan antioksidan yaitu flavonoid, saponin, dan alkaloid. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak rosella terhadap penurunan gejala penyakit parkinson.Penelitian ini menggunakan hewan uji tikus putih galur Sprague dawley sebanyak 35 ekor, tikus dibagi menjadi 7 kelompo

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Quintans, Jullyana de Souza Siqueira, Rafael dos Santos Alves, Darlisson de Alexandria Santos, et al. "Antinociceptive effect of Aristolochia trilobata stem essential oil and 6-methyl-5-hepten-2yl acetate, its main compound, in rodents." Zeitschrift für Naturforschung C 72, no. 3-4 (2017): 93–97. http://dx.doi.org/10.1515/znc-2016-0053.

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Abstract Aristolochia trilobata L. is an aromatic plant, popularly known as “mil-homens”, and its essential oil (EO) is generally used to treat colic, diarrhea and dysentery disorders. We evaluated the antinociceptive effect of A. trilobata stem EO and of its major compound, the (R)-(-)-6-methyl-5-hepten-2-yl acetate (sulcatyl acetate: SA), using acetic acid (0.85%)-induced writhing response and formalin-induced (20 μL of 1%) nociceptive behavior in mice. We also evaluated the EO and SA effect on motor coordination, using the rota-rod apparatus. EO (25, 50 and 100 mg/kg) or SA (25 and 50 mg/kg

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Sunwoo, Yun-Young, Sang In Park, Yong-An Chung, et al. "A Pilot Study for the Neuroprotective Effect of Gongjin-dan on Transient Middle Cerebral Artery Occlusion-Induced Ischemic Rat Brain." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/682720.

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In this study, we investigated whether gongjin-dan improves functional recovery and has neuroprotective effects on reducing the infarct volume after transient middle cerebral artery occlusion (MCAo). Infarct volume was measured using TTC staining and glucose utilization by F-18 FDG PET. Functional improvement was evaluated with the Rota-rod, treadmill, Garcia score test, and adhesive removal test. At 14 days after MCAo, neuronal cell survival, astrocytes expansion, and apoptosis were assessed by immunohistofluorescence staining in the peri-infarct region. Also, the expression of neurotrophic f

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Passos, Flávia Franceli de Brito, Everton Moraes Lopes, Jonas Moura de Araújo та ін. "Involvement of Cholinergic and Opioid System inγ-Terpinene-Mediated Antinociception". Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/829414.

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The literature shows that the monoterpenes are great candidates for the development of new drugs for the treatment of various pathological processes, including painful conditions. The gamma terpinene (γ-TPN) is a monoterpene present in plant species that have multiple pharmacological properties and has structural similarity to antinociceptive monoterpenes, such as limonene and alpha-phellandrene. Theγ-TPN molecular mass was evaluated by mass spectrometry and showed a pseudomolecular ion withm/z137.0 Da. The animals did not present any signs of acute toxicity at 2 g/kg, p.o.γ-TPN (1.562 to 50 m

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Opretzka, Luíza Carolina França, Max Denisson Maurício Viana, Alyne Almeida de Lima, et al. "Cleomin Exerts Acute Antinociceptive Effects in Mice via GABAB and Muscarinic Receptors." Pharmaceuticals 16, no. 11 (2023): 1547. http://dx.doi.org/10.3390/ph16111547.

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Cleomin, a 1,3-oxazolidine-2-thione, was recently isolated from Neocalyptrocalyx longifolium, a species traditionally used for treating painful conditions. Reports about the pharmacological activities of cleomin are lacking. Here, the antinociceptive effects of cleomin were investigated using mice models of pain, namely the formalin, the cold plate, and the tail flick tests. Motor integrity was assessed in the rota-rod test. Antagonism assays and in silico docking analyses were performed to investigate the putative mechanisms of action. Cleomin (12.5–25 mg/kg), at doses that did not induce mot

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Zhou, Yu, Zegang Ma, and Qi Liu. "Olfactory Discrimination Deficits in A53T Alpha-Synuclein Transgenic Mice at 3 Months." International Journal of Sciences Volume 4, no. 2015-10 (2015): 12–15. https://doi.org/10.5281/zenodo.3349029.

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Parkinson's disease (PD) is a kind of typical neurodegenerative diseases. Previously, clinical studies have showed that deficits in olfactory and cognitive functions precede motor-symptoms in PD. However, the mechanisms of olfactory discrimination deficits in early stage of PD is still unknown. In this study, we aimed to clarify the characteristics of olfactory deficits in A53T transgenic mice and test the possible mechanisms involved. By the elevated plus maze and bedding test, we showed that A53T transgenic mice at 3 months exhibit no hyperactivity behavior. Olfactory discrimination test ind

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Malpezzi-Marinho, Elena Lucia Anna, Cristiane Isabel Silva Zanoni, Graziella Rigueira Molska, et al. "Antinociceptive Activity of the Skin Secretion of Phyllomedusa rohdei (Amphibia, Anura)." Toxins 12, no. 9 (2020): 589. http://dx.doi.org/10.3390/toxins12090589.

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Pain is a distressful experience that can have a major impact on an individual’s quality of life. The need for new and better analgesics has been further intensified in light of the current opioid epidemic. Substances obtained from amphibians have been shown to contain bioactive peptides that exert analgesic effects. The genus Phyllomedusa represents an important source of peptides and bioactive components. The aim of this study was to investigate the antinociceptive effects of the skin secretion of Phyllomedusa rohdei in rodent models of pain. The crude skin extract of P. rohdei was tested in

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